Detailed information for compound 1359358

Basic information

Technical information
  • TDR Targets ID: 1359358
  • Name: 4-chloro-2-methyl-N-(5-methyl-1,2-oxazol-3-yl )pyrazole-3-carboxamide
  • MW: 240.646 | Formula: C9H9ClN4O2
  • H donors: 1 H acceptors: 3 LogP: 1.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1onc(c1)NC(=O)c1c(Cl)cnn1C
  • InChi: 1S/C9H9ClN4O2/c1-5-3-7(13-16-5)12-9(15)8-6(10)4-11-14(8)2/h3-4H,1-2H3,(H,12,13,15)
  • InChiKey: GAFNWTSFMVGWLJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-2-methyl-N-(5-methylisoxazol-3-yl)pyrazole-3-carboxamide
  • 4-chloro-2-methyl-N-(5-methyl-3-isoxazolyl)-3-pyrazolecarboxamide
  • ZINC00483836
  • Oprea1_488722
  • 4-chloro-1-methyl-N-(5-methyl-3-isoxazolyl)-1H-pyrazole-5-carboxamide
  • MLS000324949
  • SMR000159401

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0009 0.0054
Loa Loa (eye worm) hypothetical protein 0.0066 0.0128 0.0274
Leishmania major cysteine peptidase A (CPA) 0.0395 0.1461 0.8759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.0329 0.1667
Loa Loa (eye worm) fibroinase 0.0395 0.1461 0.3139
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0005 0.001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0395 0.1461 0.1461
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0127 0.0374 0.0781
Mycobacterium tuberculosis Conserved protein 0.0117 0.0334 0.0974
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0076 0.0169 0.0353
Schistosoma mansoni inositol monophosphatase 0.0076 0.0166 0.0347
Entamoeba histolytica cysteine proteinase 1, putative 0.0177 0.0576 0.3914
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1181 0.4654 0.973
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0022 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0395 0.1461 0.8763
Mycobacterium tuberculosis Probable lipase LipD 0.0117 0.0334 0.0974
Mycobacterium ulcerans esterase/lipase LipP 0.0117 0.0334 0.1164
Schistosoma mansoni histone deacetylase 4 5 0.0079 0.0178 0.0373
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1227 0.6299
Loa Loa (eye worm) hypothetical protein 0.1181 0.4654 1
Brugia malayi glutathione reductase 0.0049 0.0058 0.0124
Giardia lamblia Cathepsin L-like protease 0.0116 0.0329 0.1072
Brugia malayi histone deacetylase 1 (HD1) 0.0097 0.0251 0.0538
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0169 0.1155
Brugia malayi histone deacetylase 11 0.005 0.0061 0.013
Echinococcus multilocularis histone deacetylase 6 0.0079 0.0178 0.0178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.1003 0.2098
Brugia malayi Cathepsin L-like precursor 0.0334 0.1214 0.2609
Brugia malayi beta-lactamase family protein 0.0117 0.0334 0.0718
Loa Loa (eye worm) hypothetical protein 0.0334 0.1214 0.2609
Schistosoma mansoni amine oxidase 0.0055 0.0083 0.0173
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0177 0.0576 0.1203
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0166 0.0823
Echinococcus multilocularis beta LACTamase domain containing family member 0.0117 0.0334 0.0334
Schistosoma mansoni inositol monophosphatase 0.0076 0.0166 0.0347
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.004 0.0022 0.0129
Onchocerca volvulus 0.0395 0.1461 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0329 0.0707
Brugia malayi Papain family cysteine protease containing protein 0.0177 0.0576 0.1237
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0524 0.0524
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.011 0.0304 0.0654
Brugia malayi Papain family cysteine protease containing protein 0.0116 0.0329 0.0707
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0083 0.0566
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0116 0.0329 0.0707
Loa Loa (eye worm) cysteine protease 0.0395 0.1461 0.3139
Loa Loa (eye worm) hypothetical protein 0.0061 0.0106 0.0228
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0055 0.0083 0.0566
Trypanosoma cruzi cysteine proteinase, putative 0.0177 0.0576 0.1225
Giardia lamblia Cathepsin B precursor 0.0116 0.0329 0.1072
Loa Loa (eye worm) hypothetical protein 0.0117 0.0334 0.0718
Brugia malayi mbt repeat family protein 0.0096 0.025 0.0537
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0116 0.0329 0.2254
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0169 0.0838
Schistosoma mansoni calpain-7 (C02 family) 0.005 0.006 0.0126
Loa Loa (eye worm) hypothetical protein 0.0097 0.0252 0.054
Giardia lamblia Cysteine protease 0.0116 0.0329 0.1072
Echinococcus multilocularis snurportin 1 0.0372 0.1368 0.1368
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0076 0.0169 0.0978
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.1944 1
Giardia lamblia Cathepsin L-like protease 0.0116 0.0329 0.1072
Onchocerca volvulus 0.0395 0.1461 1
Trichomonas vaginalis esterase, putative 0.0117 0.0334 0.1692
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0076 0.0169 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0076 0.0169 0.1012
Schistosoma mansoni hypothetical protein 0.0127 0.0374 0.0781
Echinococcus granulosus cathepsin b 0.1181 0.4654 0.973
Entamoeba histolytica cysteine protease, putative 0.0116 0.0329 0.222
Plasmodium vivax histone deacetylase, putative 0.0079 0.0178 0.122
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0058 0.0395
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.0524 0.1096
Schistosoma mansoni cathepsin F (C01 family) 0.0334 0.1214 0.2539
Echinococcus granulosus cathepsin L 0.0116 0.0329 0.0688
Schistosoma mansoni hypothetical protein 0.0127 0.0374 0.0781
Schistosoma mansoni hypothetical protein 0.0601 0.2301 0.481
Loa Loa (eye worm) hypothetical protein 0.0097 0.0251 0.0538
Loa Loa (eye worm) hypothetical protein 0.0336 0.1222 0.2626
Brugia malayi Cathepsin L-like cysteine proteinase 0.0334 0.1214 0.2609
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0116 0.0329 0.0707
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Trypanosoma cruzi cysteine proteinase, putative 0.0177 0.0576 0.1225
Entamoeba histolytica cysteine proteinase, putative 0.0177 0.0576 0.3914
Plasmodium vivax serine-repeat antigen (SERA) 0.0116 0.0329 0.2254
Trypanosoma brucei PAB1-binding protein , putative 0.0101 0.027 0.1621
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0127 0.0374 0.0803
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0116 0.0329 0.1667
Loa Loa (eye worm) hypothetical protein 0.0134 0.0403 0.0866
Plasmodium vivax vivapain-2 0.0395 0.1461 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0169 0.0547 1
Echinococcus multilocularis GPCR, family 2 0.0127 0.0374 0.0374
Leishmania major cathepsin L-like protease 0.0395 0.1461 0.8759
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0313 0.0899
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0055 0.0083 0.016
Brugia malayi cathepsin F-like cysteine proteinase 0.0061 0.0105 0.0225
Echinococcus multilocularis calpain A 0.0111 0.031 0.031
Plasmodium vivax histone deacetylase 1, putative 0.0097 0.0251 0.1716
Trichomonas vaginalis glucosylceramidase, putative 0.0355 0.1301 0.6679
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0134 0.0403 0.0843
Plasmodium falciparum ataxin-2 like protein, putative 0.0101 0.027 0.185
Loa Loa (eye worm) cathepsin B 0.0445 0.1667 0.3581
Schistosoma mansoni histone deacetylase hda2 0.005 0.0061 0.0127
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0054 0.0112
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.0318 0.0683
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0009 0.0009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0117 0.0334 0.0974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0177 0.0576 0.2938
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0096 0.025 0.166
Loa Loa (eye worm) hypothetical protein 0.0061 0.0105 0.0225
Echinococcus granulosus cathepsin l1 0.0334 0.1214 0.2539
Plasmodium vivax unspecified product 0.0116 0.0329 0.2254
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0112 0.0234
Trypanosoma cruzi cysteine protease, putative 0.0177 0.0576 0.1225
Treponema pallidum exodeoxyribonuclease (exoA) 0.0076 0.0169 0.5
Schistosoma mansoni transient receptor potential channel 0.0097 0.0252 0.0526
Schistosoma mansoni hypothetical protein 0.1213 0.4783 1
Trypanosoma brucei hypothetical protein, conserved 0.0117 0.0334 0.2005
Echinococcus multilocularis histone deacetylase 0.0079 0.0178 0.0178
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0127 0.0374 0.0374
Toxoplasma gondii LsmAD domain-containing protein 0.0101 0.027 0.1621
Schistosoma mansoni hypothetical protein 0.1213 0.4783 1
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Echinococcus granulosus histone deacetylase 6 0.0079 0.0178 0.0373
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.0466 0.1001
Entamoeba histolytica cysteine protease, putative 0.0395 0.1461 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0053 0.0075 0.0148
Loa Loa (eye worm) hypothetical protein 0.0117 0.0334 0.0718
Loa Loa (eye worm) transcription factor SMAD2 0.0373 0.1375 0.2954
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0177 0.0576 0.1225
Giardia lamblia Cysteine protease 0.0116 0.0329 0.1072
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0111 0.031 0.0648
Brugia malayi hypothetical protein 0.0065 0.0124 0.0267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0395 0.1461 0.8763
Loa Loa (eye worm) calpain family protein 1 0.0106 0.0291 0.0624
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0119 0.0119
Chlamydia trachomatis protoporphyrinogen oxidase 0.0055 0.0083 0.5
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0006 0.0038
Echinococcus granulosus histone deacetylase 0.0079 0.0178 0.0373
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0076 0.0169 0.0362
Brugia malayi Cathepsin L-like precursor 0.0061 0.0105 0.0225
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0601 0.2301 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0194 0.0416
Onchocerca volvulus Matrilysin homolog 0.038 0.1401 0.9585
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Trypanosoma brucei calpain-like protein, putative 0.004 0.0022 0.0129
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.0009 0.0019
Brugia malayi beta-lactamase 0.0117 0.0334 0.0718
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0111 0.031 0.0648
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.1944 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0363 0.1077
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0106 0.0291 0.0607
Trypanosoma cruzi cysteine peptidase, putative 0.0395 0.1461 0.3129
Trichomonas vaginalis penicillin-binding protein, putative 0.0117 0.0334 0.1692
Echinococcus granulosus prolyl endopeptidase 0.0134 0.0403 0.0843
Trypanosoma cruzi histone deacetylase 1, putative 0.0097 0.0251 0.0526
Loa Loa (eye worm) hypothetical protein 0.0048 0.0054 0.0115
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Leishmania major histone deacetylase, putative 0.0097 0.0251 0.1471
Brugia malayi Matrixin family protein 0.0139 0.0424 0.091
Onchocerca volvulus 0.0116 0.0329 0.2206
Echinococcus granulosus SAM and MBT domain containing protein 0.0096 0.025 0.0523
Giardia lamblia Cathepsin L precursor 0.0116 0.0329 0.1072
Schistosoma mansoni sodium/solute symporter 0.0037 0.0009 0.0019
Entamoeba histolytica cysteine proteinase, putative 0.0395 0.1461 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0022 0.0092
Echinococcus multilocularis integrin alpha 3 0.0115 0.0324 0.0324
Loa Loa (eye worm) matrixin family protein 0.0408 0.1514 0.3252
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0076 0.0169 0.0349
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0395 0.1461 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0061 0.0105 0.0225
Trypanosoma cruzi cysteine peptidase, putative 0.0395 0.1461 0.3129
Trypanosoma cruzi oligopeptidase b 0.0053 0.0075 0.0148
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0395 0.1461 0.7506
Onchocerca volvulus 0.0395 0.1461 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0055 0.0083 0.0566
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.004 0.0022 0.0129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.1003 0.1003
Giardia lamblia Cathepsin B precursor 0.0445 0.1667 1
Schistosoma mansoni alpha-glucosidase 0.0141 0.0432 0.0902
Onchocerca volvulus 0.0139 0.0424 0.2857
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0238 0.0238
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Plasmodium vivax unspecified product 0.0177 0.0576 0.394
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0112 0.0636
Onchocerca volvulus Glucosylceramidase homolog 0.0337 0.1227 0.8389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0395 0.1461 0.7506
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0005 0.001
Schistosoma mansoni histone deacetylase 4 5 0.0079 0.0178 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0116 0.0329 0.2254
Brugia malayi hypothetical protein 0.0101 0.027 0.0581
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1181 0.4654 1
Toxoplasma gondii cathepsin B 0.0445 0.1667 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0318 0.0683
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0395 0.1461 0.1461
Entamoeba histolytica cysteine proteinase, putative 0.0395 0.1461 1
Mycobacterium ulcerans dehydrogenase 0.0055 0.0083 0.0034
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0112 0.0234
Giardia lamblia Cysteine protease 0.0116 0.0329 0.1072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0116 0.0329 0.1667
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0083 0.0088
Loa Loa (eye worm) hypothetical protein 0.0139 0.0424 0.091
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0445 0.1667 0.3573
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0116 0.0329 0.2254
Schistosoma mansoni Mername-AA248 (C02 family) 0.004 0.0022 0.0045
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0166 0.1096
Loa Loa (eye worm) hypothetical protein 0.0101 0.027 0.0581
Brugia malayi calpain family protein 1 0.0106 0.0291 0.0624
Trypanosoma cruzi histone deacetylase, putative 0.0079 0.0178 0.037
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0053 0.0075 0.045
Brugia malayi hypothetical protein 0.0055 0.0083 0.0178
Echinococcus granulosus histone deacetylase 7 0.0079 0.0178 0.0373
Schistosoma mansoni cathepsin C 0.0116 0.0329 0.0688
Loa Loa (eye worm) hypothetical protein 0.0117 0.0334 0.0718
Echinococcus multilocularis histone deacetylase 3 0.0097 0.0251 0.0251
Brugia malayi mbt repeat family protein 0.0096 0.025 0.0537
Brugia malayi beta-lactamase family protein 0.0117 0.0334 0.0718
Loa Loa (eye worm) hypothetical protein 0.0117 0.0334 0.0718
Brugia malayi cathepsin F-like cysteine proteinase 0.0116 0.0329 0.0707
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1227 0.6299
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0022 0.0033
Toxoplasma gondii exonuclease III APE 0.0076 0.0169 0.1012
Trypanosoma brucei calpain-like protein, putative 0.004 0.0022 0.0129
Loa Loa (eye worm) hypothetical protein 0.0096 0.025 0.0537
Schistosoma mansoni calpain (C02 family) 0.004 0.0022 0.0045
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0055 0.0083 0.0173
Brugia malayi Inositol-1 0.0076 0.0166 0.0356
Leishmania major UDP-galactopyranose mutase 0.0055 0.0083 0.0459
Leishmania major cathepsin L-like protease 0.0395 0.1461 0.8759
Brugia malayi SWIRM domain containing protein 0.0115 0.0326 0.07
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0134 0.0403 0.2389
Trypanosoma brucei calpain-like protein, putative 0.004 0.0022 0.0129
Loa Loa (eye worm) hypothetical protein 0.0401 0.1486 0.3193
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0134 0.0267
Loa Loa (eye worm) latrophilin receptor protein 2 0.0127 0.0374 0.0803
Giardia lamblia Cathepsin B precursor 0.0116 0.0329 0.1072
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.0524 0.1127
Onchocerca volvulus 0.0117 0.0334 0.224
Brugia malayi Matrixin family protein 0.0139 0.0424 0.091
Trypanosoma brucei histone deacetylase 2 0.005 0.0061 0.0364
Schistosoma mansoni integrin alpha 0.015 0.0466 0.0974
Schistosoma mansoni cathepsin s 0.0061 0.0105 0.0219
Plasmodium falciparum serine repeat antigen 3 0.0116 0.0329 0.2254
Loa Loa (eye worm) hypothetical protein 0.0169 0.0547 0.1175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0116 0.0329 0.1667
Loa Loa (eye worm) hypothetical protein 0.021 0.0712 0.153
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0022 0.0033
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0053 0.0075 0.0414
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0112 0.0234
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0116 0.0329 0.1072
Brugia malayi Histone deacetylase 1 0.0097 0.0251 0.0538
Brugia malayi GH02984p 0.0336 0.1222 0.2626
Mycobacterium tuberculosis Probable lipase LipE 0.0117 0.0334 0.0974
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0334 0.1214 0.2599
Trichomonas vaginalis glucosylceramidase, putative 0.0355 0.1301 0.6679
Brugia malayi Probable ATP-dependent helicase DHX35 0.0276 0.0978 0.21
Onchocerca volvulus Matrilysin homolog 0.0139 0.0424 0.2857
Trypanosoma cruzi major cysteine proteinase, putative 0.0116 0.0329 0.0695
Leishmania major histone deacetylase, putative 0.0097 0.0251 0.1471
Echinococcus granulosus tumor protein p63 0.0328 0.1191 0.249
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0111 0.031 0.0648
Schistosoma mansoni calpain-7 (C02 family) 0.005 0.006 0.0126
Giardia lamblia Cysteine protease 0.0116 0.0329 0.1072
Onchocerca volvulus Cathepsin L homolog 0.0116 0.0329 0.2206
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0004
Mycobacterium leprae Probable lipase LipE 0.0117 0.0334 0.5491
Brugia malayi cathepsin Z-like cysteine proteinase 0.0116 0.0329 0.0707
Plasmodium falciparum serine repeat antigen 6 0.0116 0.0329 0.2254
Trypanosoma cruzi UDP-galactopyranose mutase 0.0055 0.0083 0.0164
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Loa Loa (eye worm) ctsf protein 0.0395 0.1461 0.3139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.0329 0.1667
Loa Loa (eye worm) hypothetical protein 0.005 0.0061 0.013
Mycobacterium ulcerans oxidoreductase 0.0055 0.0083 0.0034
Leishmania major cathepsin L-like protease 0.0395 0.1461 0.8759
Echinococcus multilocularis cysteine protease 0.0395 0.1461 0.1461
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0166 0.0343
Trypanosoma brucei cysteine peptidase C (CPC) 0.0445 0.1667 1
Echinococcus multilocularis histone deacetylase 8 0.005 0.0061 0.0061
Echinococcus granulosus histone deacetylase 6 0.0085 0.0204 0.0427
Plasmodium falciparum cysteine proteinase falcipain 1 0.0177 0.0576 0.394
Loa Loa (eye worm) hypothetical protein 0.0139 0.0424 0.091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0395 0.1461 0.8763
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0116 0.0329 0.2254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Brugia malayi cathepsin B-like cysteine proteinase 0.1181 0.4654 1
Plasmodium vivax vivapain-1 0.0177 0.0576 0.394
Mycobacterium tuberculosis Conserved protein 0.0117 0.0334 0.0974
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.0009 0.0009
Echinococcus multilocularis hypothetical protein 0.004 0.0022 0.0022
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0577 0.2202 0.4603
Mycobacterium ulcerans hypothetical protein 0.0117 0.0334 0.1164
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0252 0.0252
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0116 0.0329 0.1667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0395 0.1461 0.8763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.0329 0.1667
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0178
Trypanosoma cruzi cysteine peptidase, putative 0.0395 0.1461 0.3129
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0061 0.0105 0.0225
Onchocerca volvulus 0.0095 0.0244 0.1617
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0116 0.0329 0.1667
Echinococcus granulosus beta LACTamase domain containing family member 0.0117 0.0334 0.0699
Giardia lamblia Cathepsin B precursor 0.0116 0.0329 0.1072
Trypanosoma cruzi histone deacetylase, putative 0.0079 0.0178 0.037
Entamoeba histolytica hypothetical protein 0.0116 0.0329 0.222
Trypanosoma cruzi histone deacetylase 1, putative 0.0097 0.0251 0.0526
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0119 0.0248
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0116 0.0329 0.222
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0166 0.0823
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0116 0.0329 0.2254
Trypanosoma brucei antigen, putative 0.004 0.0022 0.0129
Echinococcus multilocularis solute carrier family 5 0.0037 0.0009 0.0009
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0166 0.096
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0252 0.0526
Brugia malayi prolyl oligopeptidase family protein 0.0134 0.0403 0.0866
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.1003 0.1003
Leishmania major cathepsin L-like protease 0.0395 0.1461 0.8759
Entamoeba histolytica cysteine proteinase 2 0.0177 0.0576 0.3914
Loa Loa (eye worm) inositol-1 0.0076 0.0166 0.0356
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0022 0.0092
Echinococcus multilocularis calpain 7 (C02 family) 0.004 0.0022 0.0022
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0116 0.0329 0.0688
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0053 0.0075 0.0061
Schistosoma mansoni integrin alpha-ps 0.0035 0 0.0001
Echinococcus multilocularis geminin 0.1213 0.4783 0.4783
Loa Loa (eye worm) hypothetical protein 0.0036 0.0005 0.001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0116 0.0329 0.0688
Schistosoma mansoni inositol transporter 0.0037 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0009 0.0019
Echinococcus multilocularis integrin alpha ps 0.0067 0.0131 0.0131
Giardia lamblia Cathepsin B precursor 0.0116 0.0329 0.1072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.012 0.0346 0.1015
Loa Loa (eye worm) hypothetical protein 0.0094 0.0242 0.0519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.1944 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0401 0.1486 0.3193
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0313 0.0899
Echinococcus granulosus calpain 5 0.004 0.0022 0.0045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0282 0.1003 0.2156
Echinococcus multilocularis calpain 0.004 0.0022 0.0022
Loa Loa (eye worm) MBCTL1 0.011 0.0304 0.0654
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0251 0.1261
Brugia malayi Calcitonin receptor-like protein seb-1 0.0401 0.1486 0.3193
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0109 0.0302 0.0632
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Trypanosoma cruzi prolyl endopeptidase 0.0134 0.0403 0.0853
Mycobacterium leprae conserved hypothetical protein 0.0117 0.0334 0.5491
Schistosoma mansoni transient receptor potential channel 0.0064 0.0119 0.0248
Echinococcus multilocularis cathepsin L cysteine protease 0.0395 0.1461 0.1461
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1227 0.6299
Toxoplasma gondii preprocathepsin c precursor, putative 0.0116 0.0329 0.1975
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.011 0.0304 0.0636
Brugia malayi Latrophilin receptor protein 2 0.0127 0.0374 0.0803
Echinococcus multilocularis cysteine protease 0.0395 0.1461 0.1461
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0112 0.0672
Echinococcus multilocularis 0.0055 0.0083 0.0083
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0313 0.0899
Schistosoma mansoni high-affinity choline transporter 0.0336 0.1222 0.2555
Plasmodium falciparum glutathione reductase 0.0049 0.0058 0.0395
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0116 0.0329 0.222
Loa Loa (eye worm) histone deacetylase 0.0079 0.0178 0.0383
Trypanosoma brucei histone deacetylase 4 0.0079 0.0178 0.1069
Trypanosoma brucei oligopeptidase b 0.0053 0.0075 0.045
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.0105 0.0212
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.011 0.0304 0.0304
Mycobacterium tuberculosis Probable reductase 0.0112 0.0313 0.0899
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.0329 0.1667
Loa Loa (eye worm) histone deacetylase 7A 0.0079 0.0178 0.0383
Mycobacterium ulcerans lipase LipD 0.0117 0.0334 0.1164
Brugia malayi Histone deacetylase family protein 0.0079 0.0178 0.0383
Giardia lamblia Cathepsin L precursor 0.0116 0.0329 0.1072
Brugia malayi Histone deacetylase family protein 0.0079 0.0178 0.0383
Schistosoma mansoni histone deacetylase hda2 0.0085 0.0204 0.0427
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.0334 0.0705
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0127 0.0374 0.0781
Echinococcus multilocularis cathepsin L 0.0177 0.0576 0.0576
Loa Loa (eye worm) calpain 0.004 0.0022 0.0046
Loa Loa (eye worm) hypothetical protein 0.0117 0.0334 0.0718
Leishmania major histone deacetylase, putative 0.0079 0.0178 0.1035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.0329 0.1667
Onchocerca volvulus Cathepsin F homolog 0.0395 0.1461 1
Onchocerca volvulus 0.0096 0.025 0.166
Plasmodium falciparum serine repeat antigen 4 0.0116 0.0329 0.2254
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0166 0.0347
Loa Loa (eye worm) glutathione reductase 0.0049 0.0058 0.0124
Mycobacterium tuberculosis Probable hydrolase 0.0117 0.0334 0.0974
Plasmodium vivax serine-repeat antigen (SERA) 0.0116 0.0329 0.2254
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.0334 0.1692
Brugia malayi POT family protein 0.0043 0.0032 0.0069
Schistosoma mansoni myelin transcription factor 1 myt1 0.011 0.0304 0.0636
Echinococcus granulosus integrin alpha 3 0.0115 0.0324 0.0678
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0116 0.0329 0.0688
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0748 0.2897 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0097 0.0251 0.1261
Loa Loa (eye worm) hypothetical protein 0.0117 0.0336 0.0721
Plasmodium falciparum histone deacetylase, putative 0.0079 0.0178 0.122
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0119 0.0248
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0282 0.1003 0.2156
Loa Loa (eye worm) hypothetical protein 0.0276 0.0978 0.21
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0076 0.0169 0.0391
Leishmania major histone deacetylase, putative 0.0079 0.0178 0.1035
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0022 0.0033
Trypanosoma brucei histone deacetylase, putative 0.0079 0.0178 0.1069
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1227 0.6299
Giardia lamblia Histone deacetylase 0.0097 0.0251 0.0547
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0252 0.0526
Loa Loa (eye worm) hypothetical protein 0.0115 0.0326 0.07
Loa Loa (eye worm) matrix metalloproteinase 0.0139 0.0424 0.091
Plasmodium falciparum histone deacetylase 2 0.0079 0.0178 0.122
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0117 0.0334 0.0718
Entamoeba histolytica cysteine protease, putative 0.0116 0.0329 0.222
Trypanosoma cruzi cruzipain precursor, putative 0.0061 0.0105 0.0212
Mycobacterium ulcerans monoamine oxidase 0.0055 0.0083 0.0034
Echinococcus granulosus histone deacetylase 3 0.0097 0.0251 0.0524
Loa Loa (eye worm) histone deacetylase 11 0.005 0.0061 0.013
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0055 0.0083 0.0566
Brugia malayi cathepsin L-like precursor 0.0334 0.1214 0.2609
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0055 0.0083 0.0566
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Plasmodium vivax ataxin-2 like protein, putative 0.0101 0.027 0.185
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0577 0.2202 0.2202
Loa Loa (eye worm) hypothetical protein 0.0078 0.0177 0.0379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0177 0.0576 0.2938
Toxoplasma gondii histone deacetylase HDAC4 0.005 0.0061 0.0364
Echinococcus granulosus cathepsin L 0.0177 0.0576 0.1203
Plasmodium vivax histone deacetylase 2, putative 0.0079 0.0178 0.122
Echinococcus granulosus histone deacetylase 8 0.005 0.0061 0.0127
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0097 0.0251 0.1261
Leishmania major hypothetical protein, conserved 0.0101 0.027 0.1589
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0166 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 0.1214 0.6235
Echinococcus granulosus snurportin 1 0.0372 0.1368 0.286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0395 0.1461 0.7506
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.0043 0.0043
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0134 0.0403 0.0843
Leishmania major cathepsin L-like protease 0.0395 0.1461 0.8759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.0334 0.1692
Brugia malayi histone deacetylase 3 (HD3) 0.0097 0.0251 0.0538
Plasmodium falciparum serine repeat antigen 8 0.0116 0.0329 0.2254
Trypanosoma cruzi cysteine peptidase, putative 0.0177 0.0576 0.1225
Echinococcus granulosus histone deacetylase 1 0.0097 0.0251 0.0524
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1181 0.4654 0.973
Echinococcus multilocularis histone acetyltransferase MYST2 0.011 0.0304 0.0304
Onchocerca volvulus Cathepsin L homolog 0.0395 0.1461 1
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.025 0.0523
Entamoeba histolytica cysteine proteinase, putative 0.0177 0.0576 0.3914
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0116 0.0329 0.0688
Loa Loa (eye worm) POT family protein 0.0043 0.0032 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1003 0.2098
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0758 0.2935 0.6307
Echinococcus granulosus cysteine protease 0.0177 0.0576 0.1203
Echinococcus multilocularis integrin alpha ps 0.0067 0.0131 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.0334 0.0705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0395 0.1461 0.8763
Trypanosoma cruzi histone deacetylase, putative 0.005 0.0061 0.0117
Echinococcus multilocularis high affinity choline transporter 1 0.0336 0.1222 0.1222
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0076 0.0169 0.1116
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0251 0.1261
Schistosoma mansoni histone deacetylase 0.0097 0.0251 0.0524
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0053 0.0075 0.0148
Loa Loa (eye worm) hypothetical protein 0.0395 0.1461 0.3139
Echinococcus granulosus calpain A 0.004 0.0022 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0395 0.1461 0.7506
Plasmodium vivax vivapain-2 0.0395 0.1461 1
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.0334 0.1692
Echinococcus granulosus polycomb protein SCMH1 0.0096 0.025 0.0523
Echinococcus multilocularis SAM and MBT domain containing protein 0.0096 0.025 0.025
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Echinococcus granulosus integrin alpha ps 0.0067 0.0131 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0395 0.1461 0.7506
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0116 0.0329 0.2254
Brugia malayi fibroinase precursor 0.0116 0.0329 0.0707
Brugia malayi cathepsin L precursor 0.0116 0.0329 0.0707
Onchocerca volvulus 0.0117 0.0334 0.224
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0238 0.0499
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0395 0.1461 0.3139
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0022 0.0033
Leishmania major trypanothione reductase 0.0049 0.0058 0.0309
Brugia malayi Cathepsin L-like precursor 0.0395 0.1461 0.3139
Toxoplasma gondii histone deacetylase HDAC3 0.0097 0.0251 0.1503
Entamoeba histolytica cysteine proteinase, putative 0.0177 0.0576 0.3914
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0395 0.1461 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0395 0.1461 0.7506
Echinococcus granulosus cathepsin b 0.1181 0.4654 0.973
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0169 0.0838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0177 0.0576 0.3453
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0112 0.0166
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0363 0.1077
Schistosoma mansoni hypothetical protein 0.0045 0.0043 0.009
Trichomonas vaginalis penicillin-binding protein, putative 0.0117 0.0334 0.1692
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0166 0.0995
Plasmodium falciparum cysteine proteinase falcipain 3 0.0395 0.1461 1
Entamoeba histolytica cysteine proteinase, putative 0.0177 0.0576 0.3914
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0395 0.1461 0.3139
Loa Loa (eye worm) hypothetical protein 0.0035 0 0.0001
Echinococcus multilocularis calpain family protein 1, d 0.0078 0.0177 0.0177
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0058 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0395 0.1461 0.8763
Loa Loa (eye worm) hypothetical protein 0.0055 0.0083 0.0178
Loa Loa (eye worm) hypothetical protein 0.0106 0.0291 0.0624
Plasmodium falciparum serine repeat antigen 2 0.0116 0.0329 0.2254
Toxoplasma gondii histone lysine-specific demethylase 0.0055 0.0083 0.0496
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0061 0.0105 0.0225
Giardia lamblia Cathepsin B precursor 0.0116 0.0329 0.1072
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1227 0.6299
Trypanosoma brucei calpain-like protein, putative 0.004 0.0022 0.0129
Trypanosoma cruzi PAB1-binding protein , putative 0.0101 0.027 0.0568
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0116 0.0329 0.1667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0395 0.1461 0.8763
Toxoplasma gondii thioredoxin reductase 0.0049 0.0058 0.0346
Brugia malayi Angiotensin-converting enzyme family protein 0.0758 0.2935 0.6307
Trypanosoma cruzi PAB1-binding protein , putative 0.0101 0.027 0.0568
Loa Loa (eye worm) hypothetical protein 0.0116 0.0329 0.0707
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0116 0.0329 0.0688
Echinococcus multilocularis cathepsin b 0.1181 0.4654 0.4654
Plasmodium falciparum ataxin-2 like protein, putative 0.0101 0.027 0.185
Schistosoma mansoni hypothetical protein 0.0127 0.0374 0.0781
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0445 0.1667 0.3485
Brugia malayi Cathepsin L-like precursor 0.0395 0.1461 0.3139
Loa Loa (eye worm) hypothetical protein 0.011 0.0304 0.0654
Plasmodium vivax vivapain-3 0.0177 0.0576 0.394
Brugia malayi Cathepsin L-like precursor 0.0395 0.1461 0.3139
Brugia malayi Matrixin family protein 0.0139 0.0424 0.091
Echinococcus granulosus cathepsin l1 0.0395 0.1461 0.3054
Entamoeba histolytica cysteine proteinase, putative 0.0334 0.1214 0.8306
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0401 0.1486 0.3193
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0116 0.0329 0.2254
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0395 0.1461 0.7506
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0112 0.0191
Loa Loa (eye worm) hypothetical protein 0.0334 0.1214 0.2609
Trypanosoma cruzi major cysteine proteinase, putative 0.0116 0.0329 0.0695
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.0009 0.0019
Trypanosoma brucei glucosidase, putative 0.0036 0.0006 0.0038
Schistosoma mansoni ap endonuclease 0.0076 0.0169 0.0353
Loa Loa (eye worm) hypothetical protein 0.0116 0.0329 0.0707
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0166 0.0823
Echinococcus multilocularis histone deacetylase 7 0.0079 0.0178 0.0178
Brugia malayi Papain family cysteine protease containing protein 0.0395 0.1461 0.3139
Trypanosoma brucei histone deacetylase 3 0.0079 0.0178 0.1069
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0395 0.1464 0.306
Echinococcus granulosus solute carrier family 5 0.0037 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0109 0.0302 0.0649
Schistosoma mansoni inositol transporter 0.0037 0.0009 0.0019
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0116 0.0329 0.0707
Schistosoma mansoni calpain C (C02 family) 0.004 0.0022 0.0045
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0313 0.5039
Echinococcus granulosus calpain 7 C02 family 0.004 0.0022 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0116 0.0329 0.1667
Echinococcus granulosus high affinity choline transporter 1 0.0336 0.1222 0.2555
Echinococcus multilocularis prolyl endopeptidase 0.0134 0.0403 0.0403
Schistosoma mansoni hypothetical protein 0.0127 0.0374 0.0781
Giardia lamblia Cathepsin L precursor 0.0116 0.0329 0.1072
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.025 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0395 0.1461 0.8763
Onchocerca volvulus Histone deacetylase 10 homolog 0.005 0.0061 0.0356
Brugia malayi MH2 domain containing protein 0.0373 0.1375 0.2954
Entamoeba histolytica cysteine protease, putative 0.0116 0.0329 0.222
Brugia malayi Papain family cysteine protease containing protein 0.0116 0.0329 0.0707
Echinococcus granulosus histone deacetylase 6 0.0079 0.0178 0.0373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1003 0.2098
Loa Loa (eye worm) MH2 domain-containing protein 0.0373 0.1375 0.2954
Loa Loa (eye worm) hypothetical protein 0.0116 0.0329 0.0707
Toxoplasma gondii cathepsin CPC2 0.0116 0.0329 0.1975
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0395 0.1461 0.7506
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0251 0.1261
Schistosoma mansoni histone deacetylase 0.0097 0.0251 0.0524
Brugia malayi Cathepsin L-like precursor 0.0395 0.1461 0.3139
Brugia malayi Hemopexin family protein 0.0197 0.066 0.1418
Leishmania major hypothetical protein, conserved 0.0117 0.0334 0.1974
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0169 0.0547 0.1723
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0251 0.1261
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0119 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.1944 1
Brugia malayi Cathepsin L-like precursor 0.0334 0.1214 0.2609
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0117 0.0334 0.0974
Plasmodium falciparum serine repeat antigen 7 0.0116 0.0329 0.2254
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0329 0.1667
Onchocerca volvulus 0.0048 0.0054 0.0307
Brugia malayi Papain family cysteine protease containing protein 0.0116 0.0329 0.0707
Schistosoma mansoni cathepsin F (C01 family) 0.0395 0.1461 0.3054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0127 0.0374 0.0374
Echinococcus multilocularis polycomb protein SCMH1 0.0096 0.025 0.025
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0006 0.0006
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0177 0.0576 0.1203
Onchocerca volvulus 0.0395 0.1461 1
Entamoeba histolytica cysteine protease, putative 0.0116 0.0329 0.222
Brugia malayi Papain family cysteine protease containing protein 0.0177 0.0576 0.1237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Leishmania major oligopeptidase b 0.0053 0.0075 0.0414
Echinococcus multilocularis protoporphyrinogen oxidase 0.0055 0.0083 0.0083
Leishmania major cathepsin L-like protease 0.0395 0.1461 0.8759
Loa Loa (eye worm) hypothetical protein 0.0061 0.0105 0.0226
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Onchocerca volvulus Prolyl endopeptidase homolog 0.0134 0.0403 0.2714
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.0795 0.1708
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0395 0.1461 0.7506
Trypanosoma cruzi histone deacetylase, putative 0.005 0.0061 0.0117
Toxoplasma gondii histone deacetylase HDAC1 0.0079 0.0178 0.1069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Giardia lamblia Cathepsin B precursor 0.0445 0.1667 1
Entamoeba histolytica histone deacetylase, putative 0.0097 0.0251 0.1679
Echinococcus multilocularis histone deacetylase 6 0.0079 0.0178 0.0178
Brugia malayi cathepsin L-like cysteine proteinase 0.0116 0.0329 0.0707
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0334 0.1214 0.6235
Echinococcus granulosus lysine specific histone demethylase 1A 0.0055 0.0083 0.0173
Mycobacterium tuberculosis Conserved protein 0.0117 0.0334 0.0974
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0111 0.031 0.031
Echinococcus multilocularis cathepsin L 0.0116 0.0329 0.0329
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.0009 0.0019
Echinococcus granulosus cathepsin l cysteine peptidase 0.0395 0.1461 0.3054
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0116 0.0329 0.2254
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.0009 0.0009
Brugia malayi calpain family protein 1 0.0106 0.0291 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Brugia malayi amine oxidase, flavin-containing family protein 0.0061 0.0106 0.0228
Echinococcus multilocularis histone deacetylase 6 0.0085 0.0204 0.0204
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0251 0.1261
Loa Loa (eye worm) hypothetical protein 0.0127 0.0374 0.0803
Echinococcus multilocularis tumor protein p63 0.0328 0.1191 0.1191
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0109 0.0302 0.0302
Giardia lamblia Cathepsin B precursor 0.0445 0.1667 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0395 0.1464 0.1464
Mycobacterium tuberculosis Probable peptidase 0.0053 0.0075 0.0061
Schistosoma mansoni hypothetical protein 0.0274 0.0971 0.203
Giardia lamblia Hypothetical protein 0.0116 0.0329 0.1072
Toxoplasma gondii histone deacetylase HDAC2 0.0097 0.0251 0.1503
Schistosoma mansoni histone deacetylase 1 2 3 0.005 0.0061 0.0127
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0169 0.0547 0.1175
Loa Loa (eye worm) histone deacetylase 3 0.0097 0.0251 0.0538
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0117 0.0334 0.1164
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0116 0.0329 0.1667
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0117 0.0334 0.0699
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0076 0.0169 0.0349
Brugia malayi Thioredoxin reductase 0.0049 0.0058 0.0124
Brugia malayi RNA, U transporter 1 0.0099 0.0261 0.056
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0058 0.0058
Entamoeba histolytica cysteine protease, putative 0.0116 0.0329 0.222
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0166 0.0995
Echinococcus granulosus geminin 0.1213 0.4783 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0116 0.0329 0.1072
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0134 0.124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0395 0.1461 0.8763
Brugia malayi Matrixin family protein 0.0408 0.1514 0.3252
Onchocerca volvulus 0.0117 0.0334 0.224
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0117 0.0334 0.0718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0116 0.0329 0.1667
Echinococcus multilocularis calpain 5 0.004 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0395 0.1461 0.7506
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0116 0.0329 0.1072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0112 0.0166
Trypanosoma cruzi cysteine peptidase, putative 0.0395 0.1461 0.3129
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0116 0.0329 0.2254
Loa Loa (eye worm) hypothetical protein 0.0274 0.0971 0.2086
Brugia malayi latrophilin 2 splice variant baaae 0.0274 0.0971 0.2086
Trypanosoma brucei prolyl endopeptidase 0.0134 0.0403 0.2418
Plasmodium falciparum serine repeat antigen 9 0.0116 0.0329 0.2254
Toxoplasma gondii ABC1 family protein 0.0117 0.0334 0.2005
Trichomonas vaginalis histone deacetylase, putative 0.0097 0.0251 0.1261
Schistosoma mansoni ap endonuclease 0.0076 0.0169 0.0353
Loa Loa (eye worm) DEAH box polypeptide 35 0.0276 0.0978 0.21
Trypanosoma brucei histone deacetylase 1 0.0097 0.0251 0.1503
Echinococcus granulosus lysine specific histone demethylase 1A 0.0109 0.0302 0.0632
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0006 0.0013
Leishmania major cathepsin L-like protease 0.0395 0.1461 0.8759
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0022 0.0033
Trypanosoma brucei trypanothione reductase 0.0049 0.0058 0.0346
Echinococcus granulosus GPCR family 2 0.0127 0.0374 0.0781
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0313 0.0899
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1003 0.2098
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0166 0.0166
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0058 0.0121
Onchocerca volvulus 0.0334 0.1214 0.8303
Toxoplasma gondii histone deacetylase HDAC5 0.005 0.0061 0.0364
Loa Loa (eye worm) histone deacetylase 1 0.0097 0.0251 0.0538
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0116 0.0329 0.1667
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0116 0.0329 0.0688
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0116 0.0329 0.0688
Echinococcus granulosus calpain A 0.0111 0.031 0.0648
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0058 0.0111
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0009 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0395 0.1461 0.7506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Plasmodium vivax glutathione reductase, putative 0.0049 0.0058 0.0395
Echinococcus multilocularis cathepsin b 0.1181 0.4654 0.4654
Mycobacterium tuberculosis Probable esterase LipL 0.0117 0.0334 0.0974
Brugia malayi Cathepsin L-like precursor 0.0395 0.1461 0.3139
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0081 0.0189 0.0394
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.1944 1
Plasmodium falciparum protoporphyrinogen oxidase 0.0055 0.0083 0.0566
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0116 0.0329 0.1072
Loa Loa (eye worm) hypothetical protein 0.0116 0.0329 0.0707
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0116 0.0329 0.0688
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1368 0.294
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0112 0.0112
Schistosoma mansoni alpha-glucosidase 0.0141 0.0432 0.0902
Entamoeba histolytica cysteine protease, putative 0.0116 0.0329 0.222
Giardia lamblia Hypothetical protein 0.0116 0.0329 0.1072
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0363 0.1077
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0116 0.0329 0.0707
Loa Loa (eye worm) hypothetical protein 0.0116 0.0329 0.0707
Schistosoma mansoni hypothetical protein 0.0372 0.1368 0.286
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0116 0.0329 0.1667
Trypanosoma cruzi histone deacetylase, putative 0.0079 0.0178 0.037
Mycobacterium tuberculosis Possible oxidoreductase 0.0055 0.0083 0.0088
Schistosoma mansoni transient receptor potential channel 0.0064 0.0119 0.0248
Trypanosoma cruzi calpain cysteine peptidase, putative 0.004 0.0022 0.0033
Giardia lamblia Encystation-specific protease 0.0116 0.0329 0.1072
Schistosoma mansoni hypothetical protein 0.0197 0.066 0.138
Trypanosoma cruzi oligopeptidase b 0.0053 0.0075 0.0148
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0097 0.0251 0.1261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0395 0.1461 0.7506
Echinococcus multilocularis cathepsin L cysteine protease 0.0395 0.1461 0.1461
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0177 0.0576 0.1203
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1181 0.4654 0.973
Brugia malayi calpain 7 0.004 0.0022 0.0046
Echinococcus granulosus cathepsin L cysteine protease 0.0177 0.0576 0.1203
Plasmodium vivax unspecified product 0.0061 0.0105 0.0718
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0116 0.0329 0.2254
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0546 0.2077 0.7111
Plasmodium falciparum histone deacetylase 1 0.0097 0.0251 0.1716
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1181 0.4654 0.973
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0096 0.025 0.0523
Loa Loa (eye worm) hypothetical protein 0.0061 0.0105 0.0225
Schistosoma mansoni amine oxidase 0.0055 0.0083 0.0173
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0117 0.0334 0.0718
Schistosoma mansoni cathepsin B (C01 family) 0.0116 0.0329 0.0688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0395 0.1461 0.8763
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.0524 0.1127
Plasmodium falciparum serine repeat antigen 1 0.0116 0.0329 0.2254
Plasmodium vivax hypothetical protein, conserved 0.0117 0.0334 0.2287
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0601 0.2301 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0309 0.1112 0.7597
Echinococcus granulosus cathepsin L cysteine proteinase 0.0395 0.1461 0.3054
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0445 0.1667 0.857
Onchocerca volvulus 0.0066 0.0128 0.0817
Toxoplasma gondii prolyl endopeptidase 0.0134 0.0403 0.2418
Loa Loa (eye worm) matrixin family protein 0.0309 0.1112 0.2389
Plasmodium falciparum serine repeat antigen 5 0.0116 0.0329 0.2254
Onchocerca volvulus Cathepsin L homolog 0.0395 0.1461 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0117 0.0334 0.0974
Brugia malayi exodeoxyribonuclease III family protein 0.0076 0.0169 0.0362
Echinococcus granulosus histone acetyltransferase MYST2 0.011 0.0304 0.0636
Mycobacterium ulcerans beta-lactamase 0.0117 0.0334 0.1164
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0112 0.0166
Brugia malayi Cathepsin L-like precursor 0.0395 0.1461 0.3139
Toxoplasma gondii cathepsin CPL 0.0395 0.1461 0.8763
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0022 0.0092
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0524 0.0524
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0116 0.0329 0.2254
Echinococcus granulosus calpain 0.004 0.0022 0.0045
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0076 0.0169 0.0421
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0117 0.0334 0.0699
Plasmodium falciparum thioredoxin reductase 0.0049 0.0058 0.0395
Onchocerca volvulus 0.0115 0.0326 0.2181
Brugia malayi Matrixin family protein 0.0139 0.0424 0.091
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0445 0.1667 1
Loa Loa (eye worm) mbt repeat family protein 0.0096 0.025 0.0537
Echinococcus multilocularis histone deacetylase 1 0.0097 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0334 0.1214 0.2609
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0022 0.0033
Schistosoma mansoni cathepsin S (C01 family) 0.0116 0.0329 0.0688
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1227 0.6299
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0514 0.1944 0.4177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0395 0.1461 0.8763
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0055 0.0083 0.0496
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0116 0.0329 0.0688
Onchocerca volvulus 0.0197 0.066 0.4483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0177 0.0576 0.3453
Schistosoma mansoni integrin alpha-ps 0.0067 0.0131 0.0274
Giardia lamblia Cathepsin L precursor 0.0116 0.0329 0.1072
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0116 0.0329 0.2254
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.1944 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0005 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1227 0.6299
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0006 0.0014
Leishmania major cathepsin L-like protease 0.0395 0.1461 0.8759
Plasmodium vivax calpain, putative 0.004 0.0022 0.0147
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.021 0.0712 0.1489
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0083 0.0566
Giardia lamblia Cathepsin L precursor 0.0116 0.0329 0.1072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.1003 0.2098
Schistosoma mansoni cathepsin F (C01 family) 0.0395 0.1461 0.3054
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0006 0.0014
Onchocerca volvulus 0.0395 0.1461 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0166 0.0408
Entamoeba histolytica cysteine protease, putative 0.0177 0.0576 0.3914
Loa Loa (eye worm) calpain family protein 1 0.0078 0.0177 0.0379
Trypanosoma cruzi UDP-galactopyranose mutase 0.0055 0.0083 0.0164
Plasmodium vivax histone deacetylase, putative 0.005 0.0061 0.0416
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0313 0.0899
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0076 0.0169 0.0169
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0116 0.0329 0.2254
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0329 0.1667
Loa Loa (eye worm) hypothetical protein 0.0109 0.0302 0.0649
Mycobacterium ulcerans hydrolase 0.0169 0.0547 0.212
Loa Loa (eye worm) beta-lactamase 0.0117 0.0334 0.0718
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0116 0.0329 0.1667
Trypanosoma cruzi cruzipain precursor, putative 0.0395 0.1461 0.3129
Trypanosoma brucei prolyl oligopeptidase, putative 0.0053 0.0075 0.045
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0055 0.0083 0.0034
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0514 0.1944 0.4177
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0022 0.0033
Toxoplasma gondii cathepsin CPC1 0.0116 0.0329 0.1975
Onchocerca volvulus 0.0395 0.1461 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0116 0.0329 0.0707
Giardia lamblia Cathepsin L precursor 0.0116 0.0329 0.1072
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0169 0.1155
Schistosoma mansoni alpha glucosidase 0.0036 0.0006 0.0013
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0022 0.0033
Onchocerca volvulus 0.0395 0.1461 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0363 0.6113

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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