Detailed information for compound 1369057

Basic information

Technical information
  • TDR Targets ID: 1369057
  • Name: SMR000385057
  • MW: 305.294 | Formula: C15H11N7O
  • H donors: 1 H acceptors: 5 LogP: 2.23 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1nc2n(c1)cccc2)Nc1ccc(cc1)n1cnnn1
  • InChi: 1S/C15H11N7O/c23-15(13-9-21-8-2-1-3-14(21)18-13)17-11-4-6-12(7-5-11)22-10-16-19-20-22/h1-10H,(H,17,23)
  • InChiKey: ZNESDUXEMAVHRI-UHFFFAOYSA-N  


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Synonyms

  • ZINC03348648
  • MLS001010741
  • T5320294

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0267 0.2621 0.8644
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0317
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0264 0.1009
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0596 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0264 0.051
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0305 0.0649
Onchocerca volvulus 0.003 0.0173 0.007
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0428 0.0372
Loa Loa (eye worm) hypothetical protein 0.0238 0.233 0.8889
Giardia lamblia DINP protein human, muc B family 0.0039 0.0264 0.1626
Echinococcus granulosus expressed protein 0.0034 0.021 0.0112
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0522 0.0484
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8489 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0166 0.0633
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.3014 1
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1621 0.1522
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.0818 0.071
Brugia malayi Pre-SET motif family protein 0.021 0.2034 0.776
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0168 0.3128
Loa Loa (eye worm) acetyltransferase 0.0151 0.1423 0.5428
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0158 0.06
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0726 0.0728
Loa Loa (eye worm) hypothetical protein 0.0048 0.0359 0.1371
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0088 0.0772 0.2263
Onchocerca volvulus 0.0239 0.2334 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0158 0.0143
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.0857 0.0884
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0168 0.0784
Trypanosoma brucei unspecified product 0.0027 0.0139 0.0078
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.1423 0.5428
Brugia malayi mbt repeat family protein 0.0048 0.0359 0.1371
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1092 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0355 1
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0996 0.8968
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.039 0.0276
Loa Loa (eye worm) hypothetical protein 0.0076 0.0646 0.2464
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0166 0.0751
Loa Loa (eye worm) hypothetical protein 0.0029 0.0166 0.0633
Schistosoma mansoni hypothetical protein 0.0083 0.0726 0.0728
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0158 0.0521
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0996 0.8968
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.021 0.0112
Schistosoma mansoni patched 1 0.0051 0.039 0.0326
Schistosoma mansoni hypothetical protein 0.0049 0.0371 0.0303
Plasmodium vivax SET domain protein, putative 0.003 0.0173 0.3315
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0083 0.0083
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1621 0.1796
Brugia malayi PHD-finger family protein 0.0029 0.0166 0.0633
Schistosoma mansoni survival motor neuron protein 0.0049 0.0365 0.0297
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0603
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0264 0.126
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2034 0.776
Loa Loa (eye worm) hypothetical protein 0.0066 0.054 0.2061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0125 0.0475
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.1823 0.2038
Leishmania major DNA polymerase eta, putative 0.0038 0.0252 0.0469
Brugia malayi jmjC domain containing protein 0.0025 0.0117 0.0445
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0173 0.0057
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0264 0.0176
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0264 0.126
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.053 0.2023
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.039 0.1487
Giardia lamblia Cathepsin B precursor 0.0088 0.0772 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0162 0.0054
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0117 0.0445
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0158 0.06
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0264 0.051
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0726 0.0728
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0305 0.0649
Echinococcus multilocularis cathepsin b 0.0267 0.2621 0.2534
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1332 0.1451
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.021 0.0802
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0117 0.0445
Onchocerca volvulus 0.0049 0.0365 0.0951
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0322 0.0246
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0305 0.0649
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.0078
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0996 0.38
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0202 0.0294
Echinococcus multilocularis geminin 0.0205 0.198 0.1885
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0996 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0355 0.0862
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0166 0.0751
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0269 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1111 0.1188
Plasmodium vivax JmjC domain containing protein 0.0025 0.0117 0.1236
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0603
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.021 0.0095
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.1746 0.7297
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.3014 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0125 0.2232
Brugia malayi hypothetical protein 0.0025 0.0125 0.0475
Brugia malayi CHE-14 protein 0.0051 0.039 0.1487
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0117 0.1803
Brugia malayi jmjC domain containing protein 0.0025 0.0117 0.0445
Loa Loa (eye worm) hypothetical protein 0.0088 0.077 0.2939
Schistosoma mansoni hypothetical protein 0.0083 0.0726 0.0728
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0996 0.3823
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0285 0.0201
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0166 0.0059
Loa Loa (eye worm) hypothetical protein 0.0084 0.0731 0.279
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0156 0.0047
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0153 0.1446 0.1345
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0522 0.0484
Schistosoma mansoni rotamase 0.0034 0.021 0.0112
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.1423 0.1321
Schistosoma mansoni hypothetical protein 0.0029 0.0166 0.0059
Trypanosoma cruzi ISWI complex protein 0.003 0.0174 0.0199
Mycobacterium ulcerans hypothetical protein 0.0029 0.0158 0.0521
Trypanosoma cruzi ISWI complex protein 0.003 0.0174 0.0199
Echinococcus multilocularis zinc finger protein 0.0042 0.0299 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.021 0.0194
Echinococcus granulosus zinc finger protein 0.0042 0.0299 0.0217
Trichomonas vaginalis rotamase, putative 0.0033 0.0202 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0603
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0285 0.017
Echinococcus multilocularis expressed protein 0.0034 0.021 0.0095
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0168 1
Echinococcus multilocularis protein patched 0.0051 0.039 0.0276
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0355 0.3633
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0158 0.0521
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0365 0.1392
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0726 0.0616
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0359 0.029
Schistosoma mansoni zinc finger protein 0.0042 0.0299 0.0217
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0359 0.029
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0202 0.0294
Brugia malayi mbt repeat family protein 0.0048 0.0359 0.1371
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0158 0.0603
Loa Loa (eye worm) hypothetical protein 0.0062 0.0509 0.1941
Echinococcus multilocularis cathepsin b 0.0267 0.2621 0.2534
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0125 0.153
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0996 0.105
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0726 0.2769
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0264 0.0176
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.053 0.1428
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0996 0.8968
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0267 0.2621 0.2991
Brugia malayi hypothetical protein 0.0238 0.233 0.8889
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0252 0.0469
Echinococcus granulosus dna polymerase eta 0.0065 0.053 0.0494
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0168 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0153 0.1446 0.1588
Loa Loa (eye worm) hypothetical protein 0.0083 0.0726 0.2769
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.1353 0.4269
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0125 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0158 0.0521
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.233 0.2643
Plasmodium falciparum phd finger protein, putative 0.0029 0.0166 0.4444
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.039 0.0326
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0317
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0202 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0264 0.051
Echinococcus multilocularis protein dispatched 1 0.0058 0.0464 0.0352
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0402 0.0984
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0996 1
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0011 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0125 0.0028
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0264 0.0149
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0996 0.6376
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0264 0.051
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0359 0.0926
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0359 0.029
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0264 0.051
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8489 0.8472
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0996 0.089
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0996 0.38
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8489 1
Brugia malayi jmjC domain containing protein 0.0025 0.0117 0.0445
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0158 0.0521
Loa Loa (eye worm) hypothetical protein 0.0025 0.0117 0.0445
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.049 0.1869
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.021 0.0112
Echinococcus multilocularis dna polymerase eta 0.0065 0.053 0.0419
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0428 0.0372
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0168 0.4563
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.026 0.0991
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0168 0.0108
Schistosoma mansoni hypothetical protein 0.0049 0.0371 0.0303
Loa Loa (eye worm) hypothetical protein 0.0055 0.0428 0.1634
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.053 0.1428
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0428 0.0372
Loa Loa (eye worm) MBCTL1 0.0055 0.0428 0.1634
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0305 0.0649
Loa Loa (eye worm) hypothetical protein 0.0267 0.2621 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0996 0.3035
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0121 0.1119 0.1197
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0264 0.051
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0158 0.0603
Schistosoma mansoni hypothetical protein 0.0205 0.198 0.2226
Leishmania major DNA polymerase kappa, putative 0.0039 0.0264 0.051
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0125 0.0122
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0264 0.0445
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0317
Leishmania major hypothetical protein, conserved 0.003 0.0174 0.0199
Schistosoma mansoni hypothetical protein 0.0205 0.198 0.2226
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0359 0.1371
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0158 0.0143
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0168 0.3128
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0125 0.0028
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0166 0.0059
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0996 0.3823
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0252 0.2072
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0264 0.051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0317
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.0772 0.0783
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0996 0.6345
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0264 0.051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0596 0.0572
Schistosoma mansoni hypothetical protein 0.003 0.0174 0.0069
Brugia malayi Bromodomain containing protein 0.0079 0.0681 0.26
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0264 0.0445
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0264 0.051
Echinococcus granulosus expressed conserved protein 0.0112 0.1018 0.1076
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0168 0.0036
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0996 0.3823
Giardia lamblia Cathepsin B precursor 0.0088 0.0772 1
Brugia malayi Bromodomain containing protein 0.0152 0.1431 0.5462
Brugia malayi phosphofructokinase 0.011 0.0996 0.38
Toxoplasma gondii cathepsin B 0.0088 0.0772 1
Mycobacterium ulcerans hypothetical protein 0.016 0.1522 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.1522 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0322 0.0246
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0202 0.0294
Loa Loa (eye worm) hypothetical protein 0.014 0.1307 0.4987
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0283 0.1081
Brugia malayi jmjC domain containing protein 0.0096 0.0857 0.3271
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0264 0.051
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0264 0.0176
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0173 0.0862
Brugia malayi hypothetical protein 0.0016 0.0031 0.012
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0117 0.0445
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.0857 0.3271
Schistosoma mansoni hypothetical protein 0.0049 0.0365 0.0297
Toxoplasma gondii hypothetical protein 0.0049 0.037 0.3865
Schistosoma mansoni jumonji domain containing protein 0.0133 0.1242 0.1344
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0267 0.2621 0.2991
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.1823 0.1727
Loa Loa (eye worm) cathepsin B 0.0088 0.0772 0.2946
Loa Loa (eye worm) phosphofructokinase 0.011 0.0996 0.38
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0202 0.0471
Schistosoma mansoni hypothetical protein 0.0041 0.0283 0.0199
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0726 0.0728
Brugia malayi jmjC domain containing protein 0.0153 0.1446 0.5519
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0359 0.029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0264 0.051
Loa Loa (eye worm) hypothetical protein 0.0065 0.053 0.2023
Leishmania major DNA polymerase eta, putative 0.0065 0.053 0.1428
Trypanosoma brucei ISWI complex protein 0.003 0.0174 0.0199
Echinococcus granulosus dna polymerase kappa 0.0039 0.0264 0.0176
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0158 0.0521
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0726 0.0728
Leishmania major hypothetical protein, conserved 0.0025 0.0125 0.0028
Echinococcus multilocularis peregrin 0.0038 0.0251 0.0136
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0428 0.1634
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1092 0.0987
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.233 0.2239
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1092 0.1165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0522 0.0484
Brugia malayi PHD-finger family protein 0.0053 0.0408 0.1556
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0264 0.1333
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.3014 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0355 0.0284
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0158 0.0603
Schistosoma mansoni hypothetical protein 0.0292 0.2888 0.331
Loa Loa (eye worm) hypothetical protein 0.0064 0.0522 0.199
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0088 0.0772 0.2789
Brugia malayi Pre-SET motif family protein 0.003 0.0173 0.066
Loa Loa (eye worm) hypothetical protein 0.0051 0.039 0.1487
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0166 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.0078
Brugia malayi jmjC domain containing protein 0.0025 0.0117 0.0445
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0121 0.1119 0.1014
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0269 0.1192
Echinococcus granulosus cathepsin b 0.0267 0.2621 0.2991
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0359 0.029
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0264 0.051
Echinococcus granulosus peregrin 0.0038 0.0251 0.0161
Trypanosoma brucei unspecified product 0.0027 0.0139 0.0078
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0322 0.0208
Onchocerca volvulus 0.0048 0.0359 0.0926
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0264 0.051
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0428 0.0315
Trichomonas vaginalis rotamase, putative 0.0034 0.021 0.0194
Echinococcus multilocularis expressed conserved protein 0.0112 0.1018 0.0912
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0166 0.3047
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0267 0.2621 0.2991
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0269 0.1707
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0264 0.1333
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0359 0.0246
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0996 0.3035
Brugia malayi Bromodomain containing protein 0.0038 0.0251 0.0959
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0996 0.3823
Schistosoma mansoni hypothetical protein 0.0049 0.0371 0.0303
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1353 0.4269
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0428 0.0315
Echinococcus granulosus geminin 0.0205 0.198 0.2226
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0264 0.051
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0139 0.0078
Giardia lamblia Cathepsin B precursor 0.0088 0.0772 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0125 0.2232
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0156 0.004
Schistosoma mansoni bromodomain containing protein 0.0129 0.1192 0.1284
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.3014 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0173 0.0067
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0317
Trypanosoma brucei cysteine peptidase C (CPC) 0.0088 0.0772 0.2263
Brugia malayi 6-phosphofructokinase 0.011 0.0996 0.38
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0158 0.0521
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0355 0.3633
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.021 0.0112
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1353 0.4269
Schistosoma mansoni hypothetical protein 0.0049 0.0371 0.0303
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.0857 0.0884
Echinococcus granulosus cathepsin b 0.0267 0.2621 0.2991
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2334 1
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0996 0.105
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0264 0.1009
Schistosoma mansoni zinc finger protein 0.003 0.0174 0.0069
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0996 0.105
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0264 0.051
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0264 0.051
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0355 0.0862
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0158 0.0521
Schistosoma mansoni hypothetical protein 0.0083 0.0726 0.0728
Onchocerca volvulus Alhambra homolog 0.0029 0.0166 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0264 0.051
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0726 0.0616
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0522 0.041
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0168 0.4563
Trypanosoma brucei unspecified product 0.0039 0.0264 0.051
Brugia malayi 6-phosphofructokinase 0.011 0.0996 0.38
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0158 0.0143
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0726 0.2769
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0173 0.0067
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.021 0.0802
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.039 0.1024
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0267 0.2621 0.2991
Echinococcus granulosus Protein patched homolog 1 0.0051 0.039 0.0326
Schistosoma mansoni DNA polymerase eta 0.0065 0.053 0.0494
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1092 0.4168
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0264 0.051
Loa Loa (eye worm) hypothetical protein 0.0182 0.1746 0.6661
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0168 0.0784
Brugia malayi N-terminal motif family protein 0.0182 0.1746 0.6661
Brugia malayi cathepsin B-like cysteine proteinase 0.0267 0.2621 1
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0168 0.0784
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0996 0.3035
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0202 0.1302
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0264 0.1139
Loa Loa (eye worm) hypothetical protein 0.0119 0.1092 0.4168
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0359 0.0246
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.0857 0.0884
Loa Loa (eye worm) hypothetical protein 0.0025 0.0117 0.0445
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.1423 0.156
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0264 0.0149
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0088 0.0772 0.2263

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 53 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.6513 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.8349 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.0131 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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