Detailed information for compound 138802

Basic information

Technical information
  • TDR Targets ID: 138802
  • Name: 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-phene thylurea
  • MW: 362.468 | Formula: C22H26N4O
  • H donors: 2 H acceptors: 2 LogP: 4.89 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(nn1c1ccccc1)C(C)(C)C)NCCc1ccccc1
  • InChi: 1S/C22H26N4O/c1-22(2,3)19-16-20(26(25-19)18-12-8-5-9-13-18)24-21(27)23-15-14-17-10-6-4-7-11-17/h4-13,16H,14-15H2,1-3H3,(H2,23,24,27)
  • InChiKey: BHMOXCCTQPBFHP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-(5-tert-butyl-2-phenyl-pyrazol-3-yl)-3-phenethyl-urea
  • 1-(5-tert-butyl-2-phenyl-3-pyrazolyl)-3-phenethylurea
  • 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-(2-phenylethyl)urea
  • 1-(5-tert-butyl-2-phenyl-pyrazol-3-yl)-3-(2-phenylethyl)urea
  • 1-(5-tert-butyl-2-phenyl-3-pyrazolyl)-3-(2-phenylethyl)urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 13 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 13 365 aa 366 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0103 0.05 0.0994
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.005 0.0799
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0009 0.0007
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0009 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0052 0.0489
Brugia malayi major facilitator superfamily protein 0.006 0.0268 0.0629
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0159 0.0809
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0089 0.0536
Schistosoma mansoni lipoxygenase 0.0181 0.093 0.1861
Brugia malayi Pre-SET motif family protein 0.0062 0.0275 0.0646
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Brugia malayi Protein cec-1. 0.0014 0.0009 0.0021
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0034 0.0059
Leishmania major aspartyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0275 0.0545
Schistosoma mansoni hypothetical protein 0.0149 0.0757 0.1512
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Trypanosoma cruzi histidyl-tRNA synthetase 0.0015 0.0014 0.002
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0287 0.0562
Brugia malayi lysyl-tRNA synthetase 0.0096 0.0464 0.1089
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0315 0.0626
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0039 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0133 0.067 0.2566
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0078 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.0663 0.2542
Brugia malayi jmjC domain containing protein 0.0038 0.0145 0.0339
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0024 0.0068 0.0386
Loa Loa (eye worm) heterochromatin protein 1 0.0083 0.0389 0.0902
Giardia lamblia Lysyl-tRNA synthetase 0.0096 0.0464 0.2507
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.006 0.0268 0.1791
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0009 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0044 0.0217
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0089 0.1693
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0129 0.0646 1
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.0009 0.0002
Mycobacterium ulcerans lipase LipD 0.0043 0.0169 0.3474
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0189 0.0701
Echinococcus multilocularis cpg binding protein 0.0103 0.05 0.1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0108 0.1184
Toxoplasma gondii anticodon binding domain-containing protein 0.0015 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0039 0.0068
Schistosoma mansoni aspartyl-tRNA synthetase 0.0014 0.0014 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0108 0.0208
Brugia malayi Melatonin receptor type 1A 0.0013 0.0009 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0014 0.0021
Toxoplasma gondii glycyl-tRNA synthetase 0.0024 0.0068 0.0089
Plasmodium falciparum asparagine--tRNA ligase 0.0014 0.0014 0.0007
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0024 0.0068 0.0328
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0287 0.0661
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0039 0.0321
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0169 0.0325
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0179 0.0258
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.0763 0.9327
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0108 0.0669
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0663 0.1329
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0009 0.0007
Plasmodium vivax aspartate--tRNA ligase, putative 0.0014 0.0014 0.0007
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0315 0.0626
Schistosoma mansoni cytochrome P450 0.0014 0.0013 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0044 0.0217
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0039 0.0321
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0089 0.0536
Loa Loa (eye worm) hypothetical protein 0.0043 0.0169 0.0385
Leishmania major asparaginyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Toxoplasma gondii lysine-tRNA ligase 0.0096 0.0464 0.0686
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0169 0.1945
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0029 0.0054
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.0009 0.0007
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0663 0.1329
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0169
Leishmania major hypothetical protein, conserved 0.0021 0.0052 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Trypanosoma cruzi hexose transporter 0.0133 0.067 0.8161
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0169 0.3474
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0169 0.11
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis glucose transporter, putative 0.006 0.0268 0.1005
Echinococcus multilocularis chromobox protein 2 0.0014 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0056 0.0102
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0014 0.0014 0.0018
Plasmodium vivax lysine--tRNA ligase, putative 0.0096 0.0464 0.0457
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0275 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus granulosus neuropeptide receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Brugia malayi jmjC domain containing protein 0.0093 0.0449 0.1054
Brugia malayi cytochrome P450 0.0014 0.0013 0.003
Plasmodium falciparum protein kinase 7 0.1216 0.6636 0.6634
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0258 0.1358 0.2732
Loa Loa (eye worm) hypothetical protein 0.0178 0.0918 0.2145
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0089 0.031
Trypanosoma brucei glucose transporter, putative 0.0133 0.067 0.8161
Echinococcus multilocularis histidyl tRNA synthetase 0.0015 0.0014 0.0019
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0078 0.0805
Echinococcus granulosus mitogen activated protein kinase 11 0.016 0.0818 0.1641
Toxoplasma gondii ABC1 family protein 0.0043 0.0169 0.0242
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0009 0.0007
Echinococcus granulosus neuropeptide receptor 0.0013 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0169 0.2474
Schistosoma mansoni protein kinase 0.0132 0.0663 0.1323
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0009 0.0007
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.0768 0.1534
Schistosoma mansoni glucose transport protein 0.043 0.2305 0.464
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0089 0.1693
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0089 0.031
Echinococcus granulosus synaptic vesicle 2 protein 0.006 0.0268 0.053
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0013 0.0016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0218 0.1137 0.2671
Trypanosoma brucei glucose transporter 2A 0.0133 0.067 0.8161
Leishmania major glycyl tRNA synthetase, putative 0.0015 0.0014 0.002
Leishmania major hypothetical protein, conserved 0.006 0.0268 0.3167
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.0009 0.0007
Brugia malayi RNA binding protein 0.0064 0.0287 0.0673
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0009 0.0007
Echinococcus granulosus DNA methyltransferase 2, putative 0.0021 0.0048 0.0087
Echinococcus granulosus Threonyl tRNA synthetase C 0.0024 0.0068 0.0126
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0014 0.0014 0.0018
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0029 0.0041
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0021 0.0048 0.044
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.4431 0.8937
Schistosoma mansoni ap endonuclease 0.0022 0.0055 0.0093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0039 0.0323
Echinococcus multilocularis dnaJ subfamily B 0.0912 0.4958 1
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0343 0.0675
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0044 0.0217
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Schistosoma mansoni glycyl-tRNA synthetase 0.0024 0.0068 0.0119
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0663 0.1329
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0096 0.0464 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0108 0.0208
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0039 0.0321
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.0757 0.1777
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.016 0.0818 1
Trichomonas vaginalis chromobox protein, putative 0.005 0.0209 0.0776
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0089 0.031
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0129 0.0646 0.1293
Schistosoma mansoni aspartyl-tRNA synthetase 0.0014 0.0014 0.0011
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0015 0.0014 0.0009
Onchocerca volvulus 0.006 0.0268 0.1006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0055 0.0048
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0089 0.0422 0.0415
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2305 0.4644
Plasmodium falciparum aspartate--tRNA ligase 0.0014 0.0014 0.0007
Onchocerca volvulus 0.0043 0.0169 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus granulosus serotonin receptor 0.0013 0.0009 0.0007
Trypanosoma cruzi hexose transporter, putative 0.0133 0.067 0.8161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus multilocularis Polycystic kidney disease protein 0.0043 0.0172 0.0338
Onchocerca volvulus Alhambra homolog 0.0029 0.0091 0.0321
Echinococcus multilocularis Chromo domain 0.0014 0.0009 0.0007
Brugia malayi GnHR receptor homolog 0.0013 0.0009 0.002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0056 0.0102
Onchocerca volvulus 0.006 0.0268 0.1006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0172 0.0392
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0021 0.0052 0.0489
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0009 0.0007
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0048 0.0041
Echinococcus multilocularis solute carrier family 22 0.006 0.0268 0.053
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0696 0.3768 0.5673
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0055 0.0048
Echinococcus granulosus neuropeptide s receptor 0.0013 0.0009 0.0007
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0009 0.0021
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0172 0.0338
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0009 0.0007
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.016 0.0818 1
Toxoplasma gondii sugar transporter ST1 0.006 0.0268 0.0391
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0106 0.0248
Schistosoma mansoni sugar transporter 0.006 0.0268 0.0523
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0189 0.0701
Echinococcus granulosus lysyl tRNA synthetase 0.0096 0.0464 0.0926
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Mycobacterium tuberculosis Conserved protein 0.0043 0.0169 0.11
Plasmodium falciparum calcium-dependent protein kinase 4 0.0132 0.0664 0.0657
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0108 0.1184
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0052 0.0622
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0014 0.0014 0.0018
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0021 0.0052 0.0489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0723 0.1444
Treponema pallidum threonyl-tRNA synthetase 0.0024 0.0068 0.3127
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0159 0.0836
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2305 0.4644
Plasmodium vivax calcium-dependent protein kinase, putative 0.0132 0.0664 0.0657
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0013 0.0017
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2305 0.4644
Brugia malayi hypothetical protein 0.0013 0.0009 0.002
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.0009 0.0007
Schistosoma mansoni polycystin 1-related 0.0043 0.0172 0.0331
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0287 0.0673
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0014 0.0021
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0.0009 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0169
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0039 0.0321
Schistosoma mansoni loxhd1 0.0043 0.0172 0.0331
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0089 0.1206
Brugia malayi beta-lactamase family protein 0.0043 0.0169 0.0398
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0.0009 0.002
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0096 0.0464 0.7122
Trypanosoma cruzi sugar transporter, putative 0.006 0.0268 0.3167
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0146
Brugia malayi Cytochrome P450 family protein 0.0014 0.0013 0.003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0009 0.0007
Echinococcus granulosus Chromobox protein 3 0.0014 0.0009 0.0007
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0039 0.0321
Brugia malayi Disco-interacting protein 2 homolog 0.004 0.0156 0.0367
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0055 0.0129
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0048 0.0219
Trypanosoma brucei sugar transporter, putative 0.006 0.0268 0.3167
Toxoplasma gondii facilitative glucose transporter GT1 0.043 0.2305 0.3465
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0082 0.0384 0.5862
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0009 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Trichomonas vaginalis esterase, putative 0.0043 0.0169 0.0624
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0055 0.0521
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0024 0.0068 0.0126
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0039 0.0068
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0196
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0179 0.0663
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0145 0.0326
Loa Loa (eye worm) helicase 0.0014 0.0009 0.0007
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.0768 0.154
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0029 0.0048
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0013 0.0017
Trypanosoma cruzi hexose transporter, putative 0.006 0.0268 0.3167
Echinococcus multilocularis RUN 0.0043 0.0172 0.0338
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.043 0.2305 0.4644
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0115 0.0412
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0132 0.0663 0.1558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Leishmania major histidyl-tRNA synthetase, putative 0.0015 0.0014 0.002
Plasmodium falciparum calcium-dependent protein kinase 3 0.0132 0.0664 0.0657
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus multilocularis peregrin 0.0032 0.0112 0.0215
Schistosoma mansoni chromobox protein 0.0083 0.0389 0.0769
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0014 0.0021
Brugia malayi Bromodomain containing protein 0.0032 0.0112 0.0263
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0034 0.0059
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0723 0.1698
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0024 0.0068 0.0867
Chlamydia trachomatis threonine--tRNA ligase 0.0024 0.0068 0.1193
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0082 0.0384 0.2606
Echinococcus granulosus sex peptide receptor 0.0013 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0169 0.0385
Mycobacterium ulcerans hypothetical protein 0.0043 0.0169 0.3474
Brugia malayi hypothetical protein 0.006 0.0268 0.0629
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0013 0.0017
Entamoeba histolytica protein kinase, putative 0.0132 0.0663 0.364
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0055 0.0256
Entamoeba histolytica hypothetical protein 0.0026 0.0078 0.0383
Brugia malayi sulfakinin receptor protein 0.0013 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Leishmania major protein kinase, putative 0.0132 0.0663 0.8083
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0013 0.0009 0.0007
Plasmodium vivax SET domain protein, putative 0.0062 0.0275 0.0268
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0084 0.0398 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0132 0.0664 0.0988
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.034 0.1807 1
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0015 0.0014 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0089 0.0948
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Loa Loa (eye worm) hypothetical protein 0.0029 0.0091 0.0201
Trichomonas vaginalis glucose transporter, putative 0.0133 0.067 0.2566
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0021 0.0048 0.0087
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0169 0.11
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0089 0.1693
Onchocerca volvulus 0.006 0.0268 0.1006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Echinococcus multilocularis Sugar transporter ERD6 protein 0.006 0.0268 0.053
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0009 0.0002
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0009 0.0007
Echinococcus granulosus hypothetical protein 0.0013 0.0009 0.0007
Onchocerca volvulus 0.0043 0.0172 0.0636
Brugia malayi larval opioid receptor 0.0013 0.0009 0.002
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.006 0.0268 0.0261
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0082 0.0384 0.2606
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0189 0.0701
Trichomonas vaginalis myo-inositol transporter, putative 0.006 0.0268 0.1005
Leishmania major lysyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Giardia lamblia DNA repair protein RAD52 0.034 0.1807 1
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0078 0.0104
Onchocerca volvulus 0.006 0.0268 0.1006
Brugia malayi Cytochrome P450 family protein 0.0014 0.0013 0.003
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0009 0.0007
Brugia malayi beta-lactamase 0.0043 0.0169 0.0398
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0029 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Echinococcus granulosus solute carrier family 22 0.006 0.0268 0.053
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Leishmania major glucose transporter, lmgt3 0.0133 0.067 0.8161
Onchocerca volvulus 0.0036 0.0134 0.0487
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0039 0.0321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0723 0.1444
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0039 0.0166
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0089 0.0948
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0089 0.0447
Trypanosoma brucei glucose transporter, putative 0.0133 0.067 0.8161
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0663 0.1323
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0024 0.0068 0.0159
Brugia malayi chromobox protein homolog 3 0.0046 0.0189 0.0445
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0089 0.031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0255 0.0505
Loa Loa (eye worm) melatonin receptor type 1A 0.0013 0.0009 0.0007
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0132 0.0664 0.0988
Trichomonas vaginalis sugar transporter, putative 0.0133 0.067 0.2566
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0015 0.0014 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus multilocularis mitogen activated protein kinase 11 0.016 0.0818 0.1641
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0091 0.0167
Brugia malayi Dopamine receptor protein 1 0.0013 0.0009 0.002
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Brugia malayi Dopamine receptor 0.0013 0.0009 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0089 0.1206
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0078 0.0182
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0133 0.067 0.2566
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Onchocerca volvulus 0.006 0.0268 0.1006
Echinococcus granulosus chromobox protein 2 0.0014 0.0009 0.0007
Echinococcus granulosus mitogen activated protein kinase 14 0.016 0.0818 0.1641
Onchocerca volvulus 0.006 0.0268 0.1006
Brugia malayi PHD-finger family protein 0.0029 0.0091 0.0215
Onchocerca volvulus 0.006 0.0268 0.1006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0052 0.0219 0.0501
Echinococcus granulosus tar DNA binding protein 0.0064 0.0287 0.0569
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0089 0.0948
Schistosoma mansoni hypothetical protein 0.0565 0.305 0.6145
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0009 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0169 0.0398
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.043 0.2305 0.4644
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0315 0.074
Echinococcus granulosus tumor protein p63 0.0353 0.1878 0.3782
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0785 0.4258 1
Brugia malayi Sugar transporter family protein 0.043 0.2305 0.5414
Loa Loa (eye worm) hypothetical protein 0.0043 0.0169 0.0385
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0009 0.0007
Plasmodium falciparum asparagine--tRNA ligase 0.0014 0.0014 0.0007
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0108 0.0101
Giardia lamblia Glycyl-tRNA synthetase 0.0024 0.0068 0.0299
Toxoplasma gondii transporter, major facilitator family protein 0.006 0.0268 0.0391
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Loa Loa (eye worm) CXXC zinc finger family protein 0.0099 0.048 0.1116
Echinococcus granulosus glycyl tRNA synthetase 0.0024 0.0068 0.0126
Onchocerca volvulus 0.0052 0.0219 0.0816
Onchocerca volvulus 0.006 0.0268 0.1006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0108 0.0208
Plasmodium falciparum hexose transporter 0.043 0.2305 0.23
Plasmodium vivax hexose transporter 0.043 0.2305 0.23
Toxoplasma gondii sugar transporter ST3 0.006 0.0268 0.0391
Echinococcus multilocularis solute carrier family 22 0.006 0.0268 0.053
Loa Loa (eye worm) hypothetical protein 0.0046 0.0189 0.0432
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0105 0.0512 0.1191
Plasmodium vivax glycine--tRNA ligase, putative 0.0024 0.0068 0.0061
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0014 0.0014 0.0018
Schistosoma mansoni aspartyl-tRNA synthetase 0.0014 0.0014 0.0011
Echinococcus granulosus g protein coupled receptor 0.0013 0.0009 0.0007
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0091 0.0125
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0275 0.0538
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0169 0.0325
Schistosoma mansoni protein kinase 0.0132 0.0663 0.1323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0009 0.0007
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0129 0.0646 0.1516
Brugia malayi hypothetical protein 0.0043 0.0172 0.0405
Schistosoma mansoni hypothetical protein 0.0069 0.0315 0.0619
Echinococcus multilocularis chromobox protein 1 0.0083 0.0389 0.0776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0145 0.0274
Loa Loa (eye worm) hypothetical protein 0.0069 0.0315 0.0727
Brugia malayi CXXC zinc finger family protein 0.0099 0.048 0.1128
Echinococcus multilocularis geminin 0.0565 0.305 0.6148
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Loa Loa (eye worm) major facilitator superfamily transporter 0.006 0.0268 0.0616
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0039 0.0321
Giardia lamblia GTOR 0.0019 0.0039 0.0137
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0009 0.0007
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.015 0.0763 0.9327
Schistosoma mansoni glucose transport protein 0.043 0.2305 0.464
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0089 0.1693
Echinococcus multilocularis calcium dependent protein kinase 0.0124 0.0615 0.1232
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Plasmodium vivax sugar transporter, putative 0.006 0.0268 0.0261
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0179 0.0172
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0315 0.0626
Plasmodium falciparum calcium-dependent protein kinase 1 0.0132 0.0664 0.0657
Echinococcus multilocularis 0.0014 0.0013 0.0016
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0009 0.0021
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0024 0.0068 0.0146
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.0009 0.0002
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0132 0.0664 0.0657
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0219 0.0425
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0169 0.0162
Schistosoma mansoni hypothetical protein 0.0069 0.0315 0.0619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Schistosoma mansoni aspartyl-tRNA synthetase 0.0014 0.0014 0.0011
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0096 0.0464 0.56
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0663 0.1329
Schistosoma mansoni lysyl-tRNA synthetase 0.0096 0.0464 0.0919
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0258 0.1358 0.2732
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0024 0.0068 0.1218
Brugia malayi hypothetical protein 0.0013 0.0009 0.002
Echinococcus granulosus Chromo domain 0.0014 0.0009 0.0007
Onchocerca volvulus 0.0075 0.0349 0.1323
Loa Loa (eye worm) 63kd antigen 0.0014 0.0014 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0078 0.0267
Echinococcus granulosus g protein coupled receptor 0.0013 0.0009 0.0007
Echinococcus multilocularis mitogen activated protein kinase 11 0.016 0.0818 0.1641
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.0009 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0089 0.0209
Echinococcus granulosus cpg binding protein 0.0103 0.05 0.1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0015 0.0014 0.0014
Schistosoma mansoni histidyl-tRNA synthetase 0.0015 0.0014 0.0012
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.0714 0.1665
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0009 0.0007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0169 0.11
Plasmodium vivax asparagine--tRNA ligase, putative 0.0014 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Brugia malayi hypothetical protein 0.0043 0.0172 0.0405
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0086 0.0155
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0104
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.0467 0.2549
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0009 0.0007
Trypanosoma cruzi glucose transporter, putative 0.006 0.0268 0.3167
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0268 0.1005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0169 0.0385
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0055 0.0521
Plasmodium vivax multidomain scavenger receptor, putative 0.0043 0.0172 0.0165
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0663 0.1329
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0089 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0115 0.0412
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0024 0.0068 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0169
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.005 0.0043
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0009 0.0007
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.0763 0.9327
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0039 0.0321
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0009 0.0007
Echinococcus multilocularis solute carrier family 22 0.006 0.0268 0.053
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0449 0.0896
Mycobacterium ulcerans sugar transporter 0.006 0.0268 0.5655
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0108 0.0208
Onchocerca volvulus Heterochromatin protein 1 homolog 0.005 0.0209 0.0777
Echinococcus multilocularis neuropeptide receptor A26 0.0013 0.0009 0.0007
Brugia malayi Aspartyl-tRNA synthetase 0.0014 0.0014 0.0033
Giardia lamblia Sugar-proton symporter 0.006 0.0268 0.1414
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0449 0.0896
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0259 0.0595
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0078 0.0805
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0009 0.0007
Plasmodium vivax asparagine--tRNA ligase, putative 0.0014 0.0014 0.0007
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0014 0.0014 0.002
Echinococcus granulosus dnaJ subfamily B 0.0912 0.4958 1
Leishmania major aspartyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Loa Loa (eye worm) transcription factor SMAD2 0.0141 0.0714 0.1665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.016 0.0818 1
Echinococcus granulosus orexin receptor type 2 0.0013 0.0009 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.2263 0.531
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0009 0.0007
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0014 0.0014 0.0028
Echinococcus granulosus jumonji domain containing protein 0.004 0.0153 0.0298
Loa Loa (eye worm) major facilitator superfamily transporter 0.006 0.0268 0.0616
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0024 0.0068 0.1218
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Plasmodium vivax heterochromatin protein 1, putative 0.0014 0.0009 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0169 0.1945
Brugia malayi ORL1-like opioid receptor 0.0013 0.0009 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0039 0.0091
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Schistosoma mansoni hypothetical protein 0.0912 0.4958 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0218 0.1137 0.2671
Loa Loa (eye worm) cytochrome P450 0.0014 0.0013 0.0017
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0108 0.0208
Brugia malayi hypothetical protein 0.0014 0.0009 0.0021
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0132 0.0664 0.0657
Brugia malayi Cytochrome P450 family protein 0.0014 0.0013 0.003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0275 0.0402
Schistosoma mansoni hypothetical protein 0.0029 0.0091 0.0167
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.015 0.0763 0.9327
Brugia malayi Sugar transporter family protein 0.006 0.0268 0.0629
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0172 0.0338
Brugia malayi hypothetical protein 0.006 0.0268 0.0629
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.015 0.0763 0.9327
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0039 0.0077
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0039 0.0321
Giardia lamblia PHD finger protein 15 0.0029 0.0091 0.0431
Leishmania major modification methylase-like protein 0.0021 0.0048 0.044
Echinococcus multilocularis orexin receptor type 2 0.0013 0.0009 0.0007
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus granulosus GPCR family 2 0.0069 0.0315 0.0626
Schistosoma mansoni rab6-interacting 0.0043 0.0172 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.0891 0.3426
Brugia malayi hypothetical protein 0.0013 0.0009 0.002
Brugia malayi G protein-coupled receptor 0.0013 0.0009 0.002
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0034 0.0059
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0108 0.1184
Schistosoma mansoni cpg binding protein 0.0103 0.05 0.0994
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.006 0.0268 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0169 0.3474
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0055 0.0227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0144
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0169 0.0624
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0129 0.0646 0.3541
Trichomonas vaginalis sugar transport protein, putative 0.006 0.0268 0.1005
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0129 0.0646 0.1287
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0315 0.074
Brugia malayi PHD-finger family protein 0.0013 0.0006 0.0013
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0.0009 0.002
Schistosoma mansoni ap endonuclease 0.0022 0.0055 0.0093
Schistosoma mansoni glucose transport protein 0.043 0.2305 0.464
Loa Loa (eye worm) hypothetical protein 0.0218 0.1137 0.2661
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0268 0.1005
Echinococcus multilocularis tumor protein p63 0.0353 0.1878 0.3782
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Brugia malayi SET domain containing protein 0.0017 0.0029 0.0067
Trypanosoma brucei glucose transporter, putative 0.0133 0.067 0.8161
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0009 0.0007
Loa Loa (eye worm) acetyltransferase 0.0151 0.0768 0.1793
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0268 0.1005
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0169 0.0624
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0134 0.0302
Plasmodium falciparum calcium-dependent protein kinase 5 0.0132 0.0664 0.0657
Brugia malayi G-protein coupled receptor 0.0013 0.0009 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0009 0.0007
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.043 0.2305 0.4644
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0275 0.0538
Echinococcus multilocularis mitogen activated protein kinase 14 0.016 0.0818 0.1641
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0287 0.0569
Loa Loa (eye worm) hypothetical protein 0.0129 0.0646 0.1505
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0007
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0108 0.015
Leishmania major glucose transporter, lmgt2 0.0133 0.067 0.8161
Echinococcus multilocularis disco interacting protein 2 0.0041 0.0163 0.0318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0172 0.0338
Chlamydia trachomatis lysine--tRNA ligase 0.0096 0.0464 1
Trichomonas vaginalis set domain proteins, putative 0.0481 0.2584 1
Plasmodium vivax proline--tRNA ligase, putative 0.015 0.0763 0.0757
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0053 0.0226 0.0519
Schistosoma mansoni aspartyl-tRNA synthetase 0.0014 0.0014 0.0011
Echinococcus granulosus solute carrier family 22 0.006 0.0268 0.053
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0055 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0014 0.0021
Echinococcus granulosus disco interacting protein 2 0.0041 0.0163 0.0318
Schistosoma mansoni sugar transporter 0.006 0.0268 0.0523
Schistosoma mansoni histidyl-tRNA synthetase 0.0015 0.0014 0.0012
Schistosoma mansoni rab6-interacting 0.0043 0.0172 0.0331
Trypanosoma cruzi hexose transporter, putative 0.0133 0.067 0.8161
Loa Loa (eye worm) hypothetical protein 0.0022 0.0057 0.0122
Brugia malayi hypothetical protein 0.0013 0.0009 0.002
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0024 0.0068 0.0682
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.006 0.0268 0.5655
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0268 0.1005
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0169 0.11
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0268 0.1005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0039 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0075 0.0349 0.0689
Plasmodium falciparum proline--tRNA ligase 0.015 0.0763 0.0757
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0089 0.0209
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0145 0.0281
Echinococcus granulosus chromobox protein 1 0.0083 0.0389 0.0776
Schistosoma mansoni hypothetical protein 0.0014 0.0013 0.0008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0169 0.11
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0124 0.0241
Onchocerca volvulus 0.0043 0.0169 0.0624
Brugia malayi Cam kinase protein 1 0.0132 0.0663 0.1558
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.0768 0.1804
Schistosoma mansoni hypothetical protein 0.0069 0.0315 0.0619
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0024 0.0068 0.0159
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.016 0.0818 0.1909
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0009 0.0007
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0091 0.0125
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0132 0.0664 0.0657
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0039 0.0323
Loa Loa (eye worm) hypothetical protein 0.0062 0.0275 0.0633
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Brugia malayi Pre-SET motif family protein 0.0423 0.2263 0.5316
Schistosoma mansoni threonyl-tRNA synthetase 0.0015 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Echinococcus multilocularis calcium activated potassium channel 0.0014 0.001 0.0009
Brugia malayi follicle stimulating hormone receptor 0.0785 0.4258 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0039 0.0068
Echinococcus multilocularis sex peptide receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0169 0.0624
Schistosoma mansoni lipoxygenase 0.0258 0.1358 0.2727
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0055 0.0521
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0039 0.0321
Onchocerca volvulus 0.006 0.0268 0.1006
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.067 0.8161
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0015 0.0014 0.0022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0055 0.2371
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0052 0.0166
Trypanosoma brucei glucose transporter, putative 0.0133 0.067 0.8161
Echinococcus granulosus Polycystic kidney disease protein 0.0043 0.0172 0.0338
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0013 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.043 0.2305 0.8917
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0.0009 0.002
Loa Loa (eye worm) sugar transporter 0.043 0.2305 0.5408
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0315 0.0727
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0013 0.0009 0.0007
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0009 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0723 0.1444
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Plasmodium vivax threonine--tRNA ligase, putative 0.0024 0.0068 0.0061
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0663 0.1329
Schistosoma mansoni cpg binding protein 0.0099 0.048 0.0953
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0021 0.0048 0.006
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0169 0.11
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0287 0.0562
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0009 0.0007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0055 0.01
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0273 0.1436 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0041 0.0163 0.0311
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Schistosoma mansoni aspartyl-tRNA synthetase 0.0014 0.0014 0.0011
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0009 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0145 0.0274
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0009 0.0007
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0172 0.0338
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0.0009 0.002
Brugia malayi isocitrate dehydrogenase 0.0032 0.0108 0.0254
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Brugia malayi hypothetical protein 0.0013 0.0009 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Trichomonas vaginalis chromobox protein, putative 0.005 0.0209 0.0776
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0009 0.0007
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0014 0.0014 0.0018
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0014 0.0014 0.0018
Brugia malayi MH2 domain containing protein 0.0141 0.0714 0.1676
Trichomonas vaginalis helicase, putative 0.0015 0.0014 0.0021
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0024 0.0068 0.0089
Plasmodium vivax histidine--tRNA ligase, putative 0.0015 0.0014 0.0007
Onchocerca volvulus 0.006 0.0268 0.1006
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0287 0.0562
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0052 0.0277
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.016 0.0818 1
Brugia malayi RE15519p 0.0013 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0169 0.0385
Brugia malayi AKH receptor 0.0013 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Echinococcus multilocularis chromobox protein 1 0.0083 0.0389 0.0776
Brugia malayi hypothetical protein 0.0013 0.0009 0.002
Leishmania major hypothetical protein, conserved 0.0021 0.0052 0.0489
Echinococcus multilocularis GPCR, family 2 0.0069 0.0315 0.0626
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0089 0.031
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0039 0.0321
Toxoplasma gondii hypothetical protein 0.0089 0.0422 0.0624
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.006 0.0268 0.3167
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0009 0.0007
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.006 0.0268 0.5655
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.005 0.0043
Entamoeba histolytica hypothetical protein 0.0096 0.0464 0.2529
Trypanosoma brucei glucose transporter, putative 0.0133 0.067 0.8161
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0039 0.0061
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0015 0.0014 0.002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0055 0.0115
Echinococcus multilocularis somatostatin receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0014 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0218 0.1137 0.2661
Plasmodium falciparum phd finger protein, putative 0.0029 0.0091 0.0084
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0009 0.0007
Brugia malayi Doublecortin family protein 0.0043 0.0172 0.0405
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0723 0.145
Trypanosoma brucei glucose transporter, putative 0.0133 0.067 0.8161
Onchocerca volvulus 0.006 0.0268 0.1006
Echinococcus granulosus solute carrier family 22 0.006 0.0268 0.053
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0089 0.1693
Loa Loa (eye worm) hypothetical protein 0.0049 0.0204 0.0465
Trypanosoma brucei glucose transporter 1E 0.0133 0.067 0.8161
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0078 0.0146
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.0009 0.0007
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0055 0.01
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0009 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Onchocerca volvulus 0.0028 0.0089 0.0312
Brugia malayi Major Facilitator Superfamily protein 0.006 0.0268 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0723 0.145
Schistosoma mansoni lysyl-tRNA synthetase 0.0096 0.0464 0.0919
Loa Loa (eye worm) hypothetical protein 0.0149 0.0757 0.1766
Toxoplasma gondii protein kinase, putative 0.1216 0.6636 1
Echinococcus granulosus General substrate transporter 0.037 0.1972 0.3971
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0108 0.1184
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0287 0.0562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus granulosus calcium dependent protein kinase 0.0124 0.0615 0.1232
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0091 0.0201
Onchocerca volvulus 0.0043 0.0169 0.0624
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0055 0.0179
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0039 0.0045
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0108 0.0208
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0024 0.0068 0.0229
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0039 0.0077
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0132 0.0663 0.1329
Brugia malayi neuropeptide F receptor 0.0013 0.0009 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus granulosus g protein coupled receptor 0.0013 0.0009 0.0007
Onchocerca volvulus 0.006 0.0268 0.1006
Treponema pallidum glycyl-tRNA synthetase 0.0015 0.0014 0.002
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0132 0.0663 0.1547
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.067 0.2566
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0014 0.0014 0.0033
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0132 0.0663 0.1547
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0196
Schistosoma mansoni hypothetical protein 0.043 0.2305 0.464
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Onchocerca volvulus 0.0099 0.048 0.1831
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0091 0.0174
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.043 0.2305 0.4644
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0021 0.0052 0.0489
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0034 0.0059
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.006 0.0268 0.0523
Brugia malayi G-protein coupled receptor 0.0013 0.0009 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0014 0.0014 0.0016
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0009 0.0007
Echinococcus granulosus allatostatin A receptor 0.0013 0.0009 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0723 0.145
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0024 0.0068 0.0682
Onchocerca volvulus 0.006 0.0268 0.1006
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0015 0.0014 0.002
Brugia malayi Major Facilitator Superfamily protein 0.006 0.0268 0.0629
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0015 0.0014 0.0031
Echinococcus multilocularis General substrate transporter 0.037 0.1972 0.3971
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0089 0.031
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0024 0.0068 0.0328
Echinococcus multilocularis glycyl tRNA synthetase 0.0024 0.0068 0.0126
Onchocerca volvulus 0.0481 0.2584 1
Brugia malayi Dopamine receptor protein 2 0.0013 0.0009 0.002
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0024 0.0068 0.0682
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0039 0.0068
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0108 0.0101
Loa Loa (eye worm) hypothetical protein 0.0043 0.0169 0.0385
Chlamydia trachomatis proline--tRNA ligase 0.0046 0.0186 0.3815
Giardia lamblia Hexose transporter 0.006 0.0268 0.1414
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0009 0.0007
Brugia malayi Heterochromatin protein 1 0.0083 0.0389 0.0914
Toxoplasma gondii sugar transporter ST2 0.006 0.0268 0.0391
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0287 0.0661
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0009 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0169 0.0332
Loa Loa (eye worm) hypothetical protein 0.0043 0.0172 0.0392
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.0009 0.0007
Plasmodium falciparum calcium-dependent protein kinase 2 0.0132 0.0664 0.0657
Plasmodium falciparum lysine--tRNA ligase 0.0096 0.0464 0.0457
Trypanosoma brucei glucose transporter, putative 0.0133 0.067 0.8161
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0178 0.0918 0.2156
Loa Loa (eye worm) hypothetical protein 0.0096 0.0464 0.1077
Brugia malayi Sugar transporter family protein 0.006 0.0268 0.0629
Mycobacterium leprae Probable lipase LipE 0.0043 0.0169 0.2474
Brugia malayi CHD4 protein 0.0017 0.0029 0.0068
Brugia malayi P38 map kinase family protein 2 0.016 0.0818 0.192
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0096 0.0464 0.1766
Leishmania major myo-inositol/proton symporter (MIT) 0.006 0.0268 0.3167
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0057 0.0555
Schistosoma mansoni glucose transporter 0.006 0.0268 0.0523
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0089 0.0447
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Brugia malayi hypothetical protein 0.0013 0.0009 0.002
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0078 0.0139
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0153 0.0298
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0179 0.0258
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0159 0.0152
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0108 0.015
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0104
Brugia malayi hypothetical protein 0.0013 0.0009 0.002
Schistosoma mansoni hypothetical protein 0.0043 0.0172 0.0331
Leishmania major lysyl-tRNA synthetase, putative 0.0096 0.0464 0.56
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0179 0.0352
Brugia malayi neuropeptide F receptor 0.0013 0.0009 0.002
Trypanosoma cruzi hexose transporter, putative 0.0073 0.0336 0.4019
Entamoeba histolytica protein kinase, putative 0.0132 0.0663 0.364
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0663 0.1329
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0315 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0091 0.0084
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0039 0.0321
Onchocerca volvulus 0.004 0.0156 0.0574
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0138 0.0695 0.1386
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0014 0.0014 0.003
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0009 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0009 0.0007
Onchocerca volvulus 0.006 0.0268 0.1006
Echinococcus granulosus somatostatin receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0089 0.031
Leishmania major hypothetical protein, conserved 0.0043 0.0169 0.1945
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0009 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0169 0.1945
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0132 0.0664 0.0988
Leishmania major glucose transporter, lmgt1 0.0133 0.067 0.8161
Schistosoma mansoni hypothetical protein 0.0565 0.305 0.6145
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.005 0.0825
Schistosoma mansoni sugar transporter 0.006 0.0268 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0052 0.0166
Loa Loa (eye worm) hypothetical protein 0.0132 0.0663 0.1547
Treponema pallidum prolyl-tRNA synthetase 0.0046 0.0186 1
Schistosoma mansoni hypothetical protein 0.0069 0.0315 0.0619
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0013 0.0009 0.0007
Echinococcus granulosus geminin 0.0565 0.305 0.6148
Schistosoma mansoni protein kinase 0.0132 0.0663 0.1323
Brugia malayi putative neuropeptide receptor 0.0013 0.0009 0.002
Schistosoma mansoni aspartyl-tRNA synthetase 0.0014 0.0014 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Trypanosoma brucei glucose transporter, putative 0.0133 0.067 0.8161
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0108 0.0241
Echinococcus multilocularis neuropeptide s receptor 0.0013 0.0009 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Loa Loa (eye worm) RNA binding protein 0.0064 0.0287 0.0661
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0224 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Echinococcus granulosus fmrfamide receptor 0.0013 0.0009 0.0007
Onchocerca volvulus 0.0043 0.0172 0.0636
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0055 0.0521
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0275 0.0545
Entamoeba histolytica hypothetical protein 0.0097 0.0467 0.2549
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0169 0.0624
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0089 0.0447
Loa Loa (eye worm) sugar transporter 0.006 0.0268 0.0616
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0044 0.0217
Brugia malayi major facilitator superfamily protein 0.006 0.0268 0.0629
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus multilocularis mitogen activated protein kinase 14 0.016 0.0818 0.1641
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0096 0.0464 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0014 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0169 0.0624
Mycobacterium tuberculosis Conserved protein 0.0043 0.0169 0.11
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0014 0.0014 0.0021
Trypanosoma cruzi hexose transporter, putative 0.0133 0.067 0.8161
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0056 0.0117
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.067 0.8161
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.015 0.0763 0.1139
Plasmodium falciparum heterochromatin protein 1 0.0014 0.0009 0.0002
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0108 0.0254
Toxoplasma gondii aspartate-tRNA ligase 0.0014 0.0014 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Trypanosoma brucei histidyl-tRNA synthetase 0.0015 0.0014 0.002
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0014 0.0014 0.003
Echinococcus granulosus chromobox protein 1 0.0083 0.0389 0.0776
Mycobacterium tuberculosis Conserved protein 0.0043 0.0169 0.11
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0723 0.1687
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0046 0.0186 0.3833
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0021 0.0048 0.008
Brugia malayi Serotonin receptor 0.0013 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0091 0.0174
Trypanosoma brucei THT1 - hexose transporter, putative 0.0133 0.067 0.8161
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.067 0.2566
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0039 0.0061
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0024 0.0068 0.0146
Onchocerca volvulus 0.006 0.0268 0.1006
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Brugia malayi hypothetical protein 0.006 0.0268 0.0629
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0014 0.0014 0.0018
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.0009 0.0007
Leishmania major glucose transporter/membrane transporter D2, putative 0.0133 0.067 0.8161
Brugia malayi hypothetical protein 0.0013 0.0009 0.002
Echinococcus granulosus calcium activated potassium channel 0.0014 0.001 0.0009
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0169 0.0385
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0052 0.0489
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0015 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Schistosoma mansoni aspartyl-tRNA synthetase 0.0014 0.0014 0.0011
Echinococcus granulosus peregrin 0.0032 0.0112 0.0215
Brugia malayi glycyl-tRNA synthetase 0.0024 0.0068 0.0159
Brugia malayi Major Facilitator Superfamily protein 0.006 0.0268 0.0629
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.005 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Brugia malayi Serotonin receptor 0.0013 0.0009 0.002
Echinococcus multilocularis allatostatin A receptor 0.0013 0.0009 0.0007
Echinococcus multilocularis lysyl tRNA synthetase 0.0096 0.0464 0.0926
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.0009 0.0007
Brugia malayi Cytochrome P450 family protein 0.0053 0.0224 0.0527
Plasmodium falciparum glycine--tRNA ligase 0.0015 0.0014 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0169 0.11
Plasmodium vivax CDK-related protein kinase 6, putative 0.1827 1 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0696 0.3768 0.3764
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0169 0.0332
Echinococcus granulosus histidyl tRNA synthetase 0.0015 0.0014 0.0019
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0.0009 0.002
Brugia malayi hypothetical protein 0.0013 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Plasmodium falciparum threonine--tRNA ligase 0.0024 0.0068 0.0061
Loa Loa (eye worm) hypothetical protein 0.006 0.0268 0.0616
Brugia malayi TAR-binding protein 0.0064 0.0287 0.0673
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0275 0.0545
Echinococcus granulosus RUN 0.0043 0.0172 0.0338
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0287 0.0562
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus granulosus neuropeptide receptor A26 0.0013 0.0009 0.0007
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0039 0.0321
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0.0009 0.002
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.0009 0.0007
Leishmania major threonyl-tRNA synthetase, putative 0.0024 0.0068 0.0682
Echinococcus multilocularis solute carrier family 22 0.006 0.0268 0.053
Loa Loa (eye worm) hypothetical protein 0.0129 0.0646 0.1505
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0009 0.0021
Loa Loa (eye worm) doublecortin family protein 0.0043 0.0172 0.0392
Echinococcus multilocularis serotonin receptor 0.0013 0.0009 0.0007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0127 0.0635 0.0945
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0021 0.0048 0.0041
Schistosoma mansoni sugar transporter 0.006 0.0268 0.0523
Loa Loa (eye worm) TYRA-2 protein 0.0013 0.0009 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0723 0.145
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0089 0.1693
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0039 0.0166
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0055 0.093
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0039 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0389 0.1477
Chlamydia trachomatis histidine--tRNA ligase 0.0015 0.0014 0.0008
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0179 0.0663
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0389 0.1477
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0055 0.0179
Giardia lamblia Threonyl-tRNA synthetase 0.0024 0.0068 0.0299
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0129 0.0646 0.2473
Toxoplasma gondii exonuclease III APE 0.0022 0.0055 0.0069
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0009 0.0007
Plasmodium falciparum histidine--tRNA ligase, putative 0.0015 0.0014 0.0007
Mycobacterium ulcerans hypothetical protein 0.0021 0.0052 0.0873
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.0745 0.1493
Toxoplasma gondii DNA methyltransferase 2, putative 0.0021 0.0048 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Mycobacterium ulcerans beta-lactamase 0.0043 0.0169 0.3474
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0009 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0009 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0014 0.0021
Onchocerca volvulus 0.006 0.0268 0.1006
Loa Loa (eye worm) beta-lactamase 0.0043 0.0169 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0014 0.0021
Trichomonas vaginalis sugar transporter, putative 0.006 0.0268 0.1005
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0104
Mycobacterium ulcerans hypothetical protein 0.0028 0.0089 0.1693
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0108 0.0201
Mycobacterium ulcerans integral membrane transport protein 0.006 0.0268 0.5655
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0108 0.1184
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0196
Echinococcus granulosus Sugar transporter ERD6 protein 0.006 0.0268 0.053
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0132 0.0663 0.8083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0039 0.0116
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0129 0.0646 0.1287
Plasmodium falciparum mitogen-activated protein kinase 2 0.0696 0.3768 0.3764
Echinococcus granulosus solute carrier family 22 0.006 0.0268 0.053
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0096 0.0464 0.56
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.0104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0007
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0089 0.1693
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0172 0.0165
Echinococcus multilocularis serotonin receptor 0.0013 0.0009 0.0007
Trichomonas vaginalis glucose transporter, putative 0.0133 0.067 0.2566
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0089 0.031
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.006 0.0268 0.1791
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.043 0.2305 0.4644
Echinococcus multilocularis synaptic vesicle 2 protein 0.006 0.0268 0.053
Giardia lamblia Prolyl-tRNA synthetase 0.0129 0.0646 0.3522
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0129 0.0646 0.1516
Schistosoma mansoni chromobox protein 0.0083 0.0389 0.0769
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0024 0.0068 0.2114
Onchocerca volvulus Putative transporter 0.006 0.0268 0.1006
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0129 0.0646 0.1293
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0354
Brugia malayi beta-lactamase family protein 0.0043 0.0169 0.0398
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0021 0.0052 0.0066
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0024 0.0068 0.2114
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0055 0.1603

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 11000 nM Inhibition of LPS-induced tumor necrosis factor-alpha (TNF-alpha) production in THP-1 cells ChEMBL. 12086485
EC50 (functional) = 11000 nM Inhibition of LPS-induced tumor necrosis factor-alpha (TNF-alpha) production in THP-1 cells ChEMBL. 12086485
Kd (binding) = 260 nM Evaluated for inhibition of human mitogen-activated protein kinase p38 ChEMBL. 15115396
Kd (binding) = 260 nM Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay ChEMBL. 12086485
Kd (binding) = 260 nM Evaluated for inhibition of human mitogen-activated protein kinase p38 ChEMBL. 15115396
Kd (binding) = 260 nM Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay ChEMBL. 12086485

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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