Detailed information for compound 1388279

Basic information

Technical information
  • TDR Targets ID: 1388279
  • Name: [2-[6-amino-1-methyl-2,4-dioxo-3-(phenylmethy l)pyrimidin-5-yl]-2-oxoethyl] 2-(trifluoromet hyl)quinoline-4-carboxylate
  • MW: 512.437 | Formula: C25H19F3N4O5
  • H donors: 1 H acceptors: 5 LogP: 3.63 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(c1c(N)n(C)c(=O)n(c1=O)Cc1ccccc1)COC(=O)c1cc(nc2c1cccc2)C(F)(F)F
  • InChi: 1S/C25H19F3N4O5/c1-31-21(29)20(22(34)32(24(31)36)12-14-7-3-2-4-8-14)18(33)13-37-23(35)16-11-19(25(26,27)28)30-17-10-6-5-9-15(16)17/h2-11H,12-13,29H2,1H3
  • InChiKey: RMNQTQVBOHIKLD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • [2-[6-amino-1-methyl-2,4-dioxo-3-(phenylmethyl)pyrimidin-5-yl]-2-oxo-ethyl] 2-(trifluoromethyl)quinoline-4-carboxylate
  • 2-(trifluoromethyl)-4-quinolinecarboxylic acid [2-[6-amino-1-methyl-2,4-dioxo-3-(phenylmethyl)-5-pyrimidinyl]-2-oxoethyl] ester
  • 2-(trifluoromethyl)cinchoninic acid [2-[4-amino-1-(benzyl)-2,6-diketo-3-methyl-pyrimidin-5-yl]-2-keto-ethyl] ester
  • NCGC00142243-01
  • CC-PMLSC-DMA-P158
  • SDCCGMLS-0091860.P001
  • MLS000889050
  • SMR000208991

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus solute carrier family 22 0.0031 0.0163 0.0185
Echinococcus multilocularis lysyl tRNA synthetase 0.005 0.0361 0.041
Schistosoma mansoni amine GPCR 0.0049 0.0355 0.0403
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0223 0.223 0.2532
Echinococcus multilocularis peregrin 0.0225 0.2256 0.2561
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0084 0.0457
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0102 0.0048
Brugia malayi Sugar transporter family protein 0.0031 0.0163 0.0212
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.005 0.0361 0.3266
Schistosoma mansoni adenoreceptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0071 0.0323
Brugia malayi phosphofructokinase 0.0111 0.1025 0.1331
Trichomonas vaginalis glucose transporter, putative 0.0069 0.0569 0.1762
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0163 0.1026
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0187 0.1845 0.2095
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1025 0.3275
Leishmania major lysyl-tRNA synthetase, putative 0.005 0.0361 0.3266
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0569 0.1762
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0355 0.0403
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0355 0.0403
Schistosoma mansoni hypothetical protein 0.0049 0.0355 0.0403
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.013 0.0304
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0355 0.0741
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.1025 0.3203
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0201 0.1647
Brugia malayi larval opioid receptor 0.0049 0.0355 0.0461
Onchocerca volvulus 0.0031 0.0163 0.0163
Brugia malayi major facilitator superfamily protein 0.0031 0.0163 0.0212
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Brugia malayi Bromodomain containing protein 0.0039 0.0249 0.0323
Echinococcus multilocularis General substrate transporter 0.0191 0.1886 0.2141
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1025 0.3275
Trichomonas vaginalis importin beta-1, putative 0.0028 0.013 0.0304
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0569 0.1762
Loa Loa (eye worm) glutamate receptor 0.0165 0.1602 0.3344
Plasmodium falciparum importin beta, putative 0.0035 0.0201 0.018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0045
Echinococcus multilocularis jumonji domain containing protein 0.031 0.3172 0.3601
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0376 0.0488
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0068 0.056 0.054
Schistosoma mansoni glucose transport protein 0.0222 0.2223 0.2524
Brugia malayi neuropeptide F receptor 0.0049 0.0355 0.0461
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.015 0.0369
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0082 0.0705 0.08
Echinococcus granulosus jumonji domain containing protein 0.031 0.3172 0.3601
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0088 0.0027
Trypanosoma brucei glucose transporter, putative 0.0069 0.0569 0.5379
Onchocerca volvulus 0.0031 0.0163 0.0163
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0073 0.0612 0.0829
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Onchocerca volvulus 0.0049 0.0355 0.0578
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0039 0.0081
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.015 0.0129
Echinococcus multilocularis somatostatin receptor 0.0049 0.0355 0.0403
Schistosoma mansoni alpha-1 adrenergic receptor 0.0049 0.0355 0.0403
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0731 0.77 0.8742
Leishmania major protein kinase, putative 0.0068 0.056 0.5284
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0355 0.0403
Onchocerca volvulus 0.0049 0.0355 0.0578
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Onchocerca volvulus Alhambra homolog 0.0223 0.223 0.4633
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Loa Loa (eye worm) hypothetical protein 0.0042 0.0275 0.0575
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0068 0.056 0.075
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1401 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0096 0.0109
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0222 0.2223 0.2524
Brugia malayi hypothetical protein 0.0031 0.0163 0.0212
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.008 0.0031
Loa Loa (eye worm) hypothetical protein 0.005 0.0361 0.0754
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0102 0.021
Echinococcus multilocularis dna polymerase eta 0.002 0.0039 0.0044
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0072 0.0602 0.0814
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0355 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0569 0.1762
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.305 1
Trypanosoma cruzi hexose transporter 0.0069 0.0569 0.5379
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0084 0.0453
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0068 0.056 0.075
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Brugia malayi sulfakinin receptor protein 0.0049 0.0355 0.0461
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0355 0.0403
Plasmodium vivax hypothetical protein, conserved 0.0223 0.223 0.2213
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Brugia malayi Dopamine receptor 0.0049 0.0355 0.0461
Toxoplasma gondii sugar transporter ST2 0.0031 0.0163 0.0141
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0163 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0163 0.0412
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0067 0.0545 0.0619
Trypanosoma brucei glucose transporter, putative 0.0069 0.0569 0.5379
Schistosoma mansoni hypothetical protein 0.0494 0.515 0.5847
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0355 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1025 0.214
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.015 0.0369
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.015 0.0369
Echinococcus granulosus g-protein coupled receptor 0.0049 0.0355 0.0403
Mycobacterium ulcerans hypothetical protein 0.0024 0.0088 0.0479
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0049 0.0355 0.0403
Toxoplasma gondii sugar transporter ST3 0.0031 0.0163 0.0141
Brugia malayi Melatonin receptor type 1A 0.0049 0.0355 0.0461
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0042 0.028 0.1939
Brugia malayi RNA, U transporter 1 0.0099 0.0893 0.116
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0114
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0102 0.0081
Onchocerca volvulus 0.0049 0.0355 0.0578
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.305 1
Brugia malayi hypothetical protein 0.0049 0.0355 0.0461
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0743 0.0965
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.015 0.0266
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.005 0.0361 0.3266
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0355 0.0403
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0088 0.0552
Leishmania major glucose transporter, lmgt3 0.0069 0.0569 0.5379
Brugia malayi PHD-finger family protein 0.0027 0.0122 0.0159
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0049 0.0355 0.0403
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0084 0.0044
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.015 0.0369
Onchocerca volvulus 0.0031 0.0163 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0149 0.1435 0.1864
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0376 0.0488
Entamoeba histolytica Ran family GTPase 0.0026 0.0102 0.021
Echinococcus granulosus fmrfamide receptor 0.0049 0.0355 0.0403
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.028 0.1939
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0163 0.0212
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0355 0.0741
Loa Loa (eye worm) hypothetical protein 0.0203 0.2012 0.4201
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.305 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0014 0.0016
Echinococcus multilocularis Protein lozenge 0.0057 0.0439 0.0498
Brugia malayi hypothetical protein 0.0453 0.4712 0.612
Loa Loa (eye worm) hypothetical protein 0.0077 0.0654 0.1366
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0355 0.0403
Onchocerca volvulus 0.0031 0.0163 0.0163
Brugia malayi G protein-coupled receptor 0.0049 0.0355 0.0461
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0068 0.056 0.1169
Onchocerca volvulus 0.0031 0.0163 0.0163
Onchocerca volvulus 0.0031 0.0163 0.0163
Brugia malayi putative neuropeptide receptor 0.0049 0.0355 0.0461
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.305 1
Schistosoma mansoni neuropeptide receptor 0.0049 0.0355 0.0403
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Leishmania major hypothetical protein, conserved 0.0072 0.0602 0.5709
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0355 0.0403
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.056 0.0636
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8808 1
Schistosoma mansoni sugar transporter 0.0031 0.0163 0.0185
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0088 0.0479
Schistosoma mansoni hypothetical protein 0.0049 0.0355 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Onchocerca volvulus 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0014 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0039 0.0044
Echinococcus granulosus neuropeptide receptor A26 0.0049 0.0355 0.0403
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0163 0.0412
Loa Loa (eye worm) hypothetical protein 0.0027 0.0114 0.0239
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0506 0.0574
Brugia malayi jmjC domain containing protein 0.0072 0.0602 0.0782
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0049 0.0355 0.0461
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0071 0.008
Loa Loa (eye worm) sugar transporter 0.0031 0.0163 0.034
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0049 0.0355 0.0403
Plasmodium vivax sugar transporter, putative 0.0031 0.0163 0.0142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0619 0.0703
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0071 0.0432
Loa Loa (eye worm) phosphofructokinase 0.0111 0.1025 0.214
Echinococcus multilocularis dro:myosuppressin receptor 0.0049 0.0355 0.0403
Mycobacterium ulcerans sugar transporter 0.0031 0.0163 0.1026
Schistosoma mansoni cpg binding protein 0.0039 0.0242 0.0275
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.015 0.0369
Echinococcus granulosus snurportin 1 0.0372 0.3833 0.4351
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0078 0.0664 0.6341
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0088 0.0552
Schistosoma mansoni protein kinase 0.0068 0.056 0.0636
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Trypanosoma brucei sugar transporter, putative 0.0031 0.0163 0.1259
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0102 0.0642
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0121 0.0253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.305 1
Loa Loa (eye worm) sugar transporter 0.0222 0.2223 0.4641
Echinococcus multilocularis calcium dependent protein kinase 0.0064 0.0515 0.0584
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0022 0.0025
Echinococcus granulosus cpg binding protein 0.0039 0.0242 0.0275
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0022 0.0025
Plasmodium falciparum mitogen-activated protein kinase 2 0.0359 0.3699 0.3686
Chlamydia trachomatis proline--tRNA ligase 0.0024 0.008 0.1725
Echinococcus multilocularis neuropeptide FF receptor 2 0.0049 0.0355 0.0403
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0355 0.0403
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0635 0.0614
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0355 0.0403
Brugia malayi jmjC domain containing protein 0.0072 0.0602 0.0782
Trypanosoma brucei glucose transporter 1E 0.0069 0.0569 0.5379
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0201 0.02
Schistosoma mansoni neuropeptide receptor 0.0049 0.0355 0.0403
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0022 0.0025
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0049 0.0355 0.0403
Trypanosoma brucei glucose transporter, putative 0.0069 0.0569 0.5379
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0067 0.0545 0.0708
Brugia malayi hypothetical protein 0.0125 0.1178 0.1529
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0076 0.0644 0.0732
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0067 0.0545 0.3501
Echinococcus multilocularis PHD finger protein rhinoceros 0.0223 0.223 0.2532
Echinococcus granulosus jumonji domain containing 1A 0.0072 0.0602 0.0683
Entamoeba histolytica protein kinase, putative 0.0068 0.056 0.173
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0084 0.0453
Echinococcus granulosus sex peptide receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0453 0.4712 0.9838
Schistosoma mansoni glucose transport protein 0.0222 0.2223 0.2524
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 0.0479
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0222 0.0252
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0072 0.0602 0.0814
Schistosoma mansoni hypothetical protein 0.0021 0.0054 0.0061
Plasmodium vivax lysine--tRNA ligase, putative 0.005 0.0361 0.034
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0355 0.0403
Entamoeba histolytica hypothetical protein 0.0028 0.013 0.0304
Brugia malayi hypothetical protein 0.0049 0.0355 0.0461
Trichomonas vaginalis glucose transporter, putative 0.0069 0.0569 0.1762
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0102 0.0081
Brugia malayi jmjC domain containing protein 0.0072 0.0602 0.0782
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0014 0.0016
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0096 0.0109
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.005 0.0361 0.107
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1025 1
Echinococcus granulosus neuropeptide receptor 0.0049 0.0355 0.0403
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0163 0.1259
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0084 0.0457
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Brugia malayi putative neuropeptide receptor NPR1 0.0049 0.0355 0.0461
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0084 0.002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0355 0.0403
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0163 0.0185
Schistosoma mansoni sugar transporter 0.0031 0.0163 0.0185
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0183
Loa Loa (eye worm) TYRA-2 protein 0.0049 0.0355 0.0741
Echinococcus granulosus solute carrier family 22 0.0031 0.0163 0.0185
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.056 0.0636
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0163 0.0185
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0068 0.056 0.054
Onchocerca volvulus 0.0031 0.0163 0.0163
Echinococcus granulosus GPCR family 3 C terminal 0.0027 0.0114 0.013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0039 0.0044
Schistosoma mansoni opsin-like receptor 0.0049 0.0355 0.0403
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0355 0.0403
Brugia malayi CXXC zinc finger family protein 0.0035 0.02 0.0259
Loa Loa (eye worm) hypothetical protein 0.0072 0.0602 0.1257
Echinococcus granulosus 7tm_1 domain containing protein 0.0049 0.0355 0.0403
Schistosoma mansoni hypothetical protein 0.0058 0.0454 0.0515
Onchocerca volvulus Putative transporter 0.0031 0.0163 0.0163
Echinococcus granulosus serotonin receptor 0.0049 0.0355 0.0403
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0049 0.0355 0.0403
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0021 0.0044
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0071 0.0106
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0027 0.0114 0.0058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Brugia malayi Bromodomain containing protein 0.0225 0.2256 0.293
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0068 0.056 0.075
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0071 0.0106
Echinococcus multilocularis jumonji domain containing 1A 0.0072 0.0602 0.0683
Echinococcus granulosus neuropeptide s receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0223 0.223 0.4656
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.056 0.0636
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0163 0.034
Brugia malayi neuropeptide F receptor 0.0049 0.0355 0.0461
Onchocerca volvulus Poor gastrulation protein homolog 0.0027 0.0114 0.0058
Echinococcus granulosus solute carrier family 22 0.0031 0.0163 0.0185
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0454 0.0589
Brugia malayi hypothetical protein 0.0031 0.0163 0.0212
Onchocerca volvulus 0.0049 0.0355 0.0578
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0359 0.3699 0.3686
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0102 0.0642
Echinococcus granulosus peregrin 0.0225 0.2256 0.2561
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0084 0.1841
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0355 0.0403
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0222 0.2223 0.2524
Schistosoma mansoni protein kinase 0.0068 0.056 0.0636
Onchocerca volvulus 0.0049 0.0355 0.0578
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0072 0.0602 0.0683
Echinococcus multilocularis JmjC domain containing protein 4 0.0072 0.0602 0.0683
Schistosoma mansoni bromodomain containing protein 0.0067 0.0545 0.0619
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.1025 0.7296
Schistosoma mansoni hypothetical protein 0.0027 0.0114 0.013
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0222 0.2223 0.2524
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2904 0.3297
Schistosoma mansoni phosphatidylserine receptor 0.0072 0.0602 0.0683
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0068 0.056 0.054
Entamoeba histolytica protein kinase, putative 0.0068 0.056 0.173
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0088 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.305 1
Schistosoma mansoni hypothetical protein 0.0035 0.0202 0.0229
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.1025 0.1164
Echinococcus granulosus dro:myosuppressin receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Brugia malayi hypothetical protein 0.0049 0.0355 0.0461
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.013 0.0927
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0163 0.0412
Onchocerca volvulus 0.0049 0.0355 0.0578
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.1025 0.7146
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0045
Echinococcus granulosus PHD finger protein rhinoceros 0.0223 0.223 0.2532
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0071 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.305 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1025 0.3275
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0201 0.1647
Brugia malayi hypothetical protein 0.0049 0.0355 0.0461
Onchocerca volvulus 0.0049 0.0355 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0163 0.0412
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0138 0.1314 0.1491
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0049 0.0355 0.0741
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0163 0.1259
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Brugia malayi Receptor family ligand binding region containing protein 0.0042 0.0281 0.0365
Loa Loa (eye worm) hypothetical protein 0.0125 0.1178 0.2458
Onchocerca volvulus 0.0031 0.0163 0.0163
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0088 0.0162
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0183
Toxoplasma gondii facilitative glucose transporter GT1 0.0222 0.2223 0.3297
Echinococcus multilocularis neuropeptide receptor A26 0.0049 0.0355 0.0403
Schistosoma mansoni hypothetical protein 0.0372 0.3833 0.4351
Echinococcus granulosus alpha 1A adrenergic receptor 0.0049 0.0355 0.0403
Echinococcus multilocularis cpg binding protein 0.0039 0.0242 0.0275
Echinococcus granulosus metabotropic glutamate receptor 5 0.0203 0.2012 0.2285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.305 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.056 0.1169
Plasmodium vivax proline--tRNA ligase, putative 0.0078 0.0664 0.0644
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0049 0.0355 0.0403
Brugia malayi hypothetical protein 0.0049 0.0355 0.0461
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0102 0.0133
Plasmodium falciparum calcium-dependent protein kinase 3 0.0068 0.056 0.054
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0049 0.0355 0.0741
Echinococcus granulosus calcium dependent protein kinase 0.0064 0.0515 0.0584
Loa Loa (eye worm) hypothetical protein 0.0072 0.0602 0.1257
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Entamoeba histolytica hypothetical protein 0.005 0.0361 0.107
Brugia malayi Sugar transporter family protein 0.0031 0.0163 0.0212
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0042 0.0281 0.0587
Echinococcus multilocularis serotonin receptor 0.0049 0.0355 0.0403
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.0493
Brugia malayi AF-10 protein 0.0073 0.0612 0.0794
Loa Loa (eye worm) jmjC domain-containing protein 0.0274 0.2778 0.58
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.1025 0.1164
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0039 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Brugia malayi hypothetical protein 0.0049 0.0355 0.0461
Onchocerca volvulus 0.0049 0.0355 0.0578
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0163 0.0141
Echinococcus multilocularis dna polymerase kappa 0.002 0.0039 0.0044
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0049 0.0355 0.0578
Leishmania major hypothetical protein, conserved 0.0031 0.0163 0.1259
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0731 0.77 0.8742
Schistosoma mansoni jumonji/arid domain-containing protein 0.0274 0.2778 0.3154
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0355 0.0403
Plasmodium falciparum calcium-dependent protein kinase 1 0.0068 0.056 0.054
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Onchocerca volvulus 0.0031 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0102 0.0642
Leishmania major glucose transporter/membrane transporter D2, putative 0.0069 0.0569 0.5379
Schistosoma mansoni DNA polymerase eta 0.002 0.0039 0.0044
Echinococcus granulosus allatostatin A receptor 0.0049 0.0355 0.0403
Schistosoma mansoni glucose transport protein 0.0222 0.2223 0.2524
Schistosoma mansoni biogenic amine receptor 0.0049 0.0355 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Schistosoma mansoni hypothetical protein 0.0073 0.0612 0.0695
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0039 0.0044
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0068 0.056 0.5284
Schistosoma mansoni ap endonuclease 0.0023 0.0071 0.008
Plasmodium vivax hexose transporter 0.0222 0.2223 0.2206
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0355 0.0403
Schistosoma mansoni neuropeptide receptor 0.0049 0.0355 0.0403
Schistosoma mansoni histamine h1 receptor 0.0049 0.0355 0.0403
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0355 0.0403
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0073 0.0612 0.5808
Schistosoma mansoni ran 0.0026 0.0102 0.0116
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0355 0.0403
Echinococcus multilocularis G-protein coupled receptor, putative 0.0049 0.0355 0.0403
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0355 0.0403
Giardia lamblia Hexose transporter 0.0031 0.0163 0.0412
Schistosoma mansoni hypothetical protein 0.0049 0.0355 0.0403
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0743 0.0844
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0049 0.0355 0.0461
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.056 0.0636
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0222 0.2223 0.2524
Loa Loa (eye worm) hypothetical protein 0.0072 0.0606 0.1266
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0084 0.002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0355 0.0403
Schistosoma mansoni amine GPCR 0.0049 0.0355 0.0403
Brugia malayi G protein-coupled receptor F59B2.13 0.0049 0.0355 0.0461
Onchocerca volvulus 0.0031 0.0163 0.0163
Brugia malayi metabotropic glutamate receptor type 2 0.008 0.0692 0.0898
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0088 0.0479
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Brugia malayi hypothetical protein 0.0031 0.0163 0.0212
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Brugia malayi GnHR receptor homolog 0.0049 0.0355 0.0461
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.1025 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0223 0.223 0.3308
Trypanosoma brucei glucose transporter, putative 0.0069 0.0569 0.5379
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0071 0.0106
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0355 0.0403
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0096 0.0109
Schistosoma mansoni hypothetical protein 0.0223 0.223 0.2532
Brugia malayi jmjC domain containing protein 0.0274 0.2778 0.3608
Brugia malayi G-protein coupled receptor 0.0049 0.0355 0.0461
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8808 1
Toxoplasma gondii protein kinase, putative 0.0628 0.6599 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Schistosoma mansoni jumonji/arid domain-containing protein 0.0274 0.2778 0.3154
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0163 0.0185
Loa Loa (eye worm) hypothetical protein 0.0067 0.0545 0.1138
Onchocerca volvulus 0.0049 0.0355 0.0578
Trypanosoma brucei glucose transporter, putative 0.0069 0.0569 0.5379
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.305 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0067 0.0545 0.0708
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.015 0.0121
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0569 0.5379
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0163 0.1095
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0664 0.6341
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0602 0.1257
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0054 0.0112
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0071 0.0106
Echinococcus granulosus dna polymerase eta 0.002 0.0039 0.0044
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0072 0.0602 0.5709
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Echinococcus granulosus lysine specific demethylase 5A 0.0274 0.2778 0.3154
Schistosoma mansoni amine GPCR 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Brugia malayi Bromodomain containing protein 0.0079 0.0675 0.0876
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.015 0.0369
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0068 0.056 0.0727
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0355 0.0403
Onchocerca volvulus 0.0031 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0049 0.0355 0.0403
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.056 0.173
Plasmodium vivax JmjC domain containing protein 0.0072 0.0602 0.0582
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0014 0.0016
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0222 0.2223 0.2524
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0201 0.0229
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0163 0.1259
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Toxoplasma gondii 6-phosphofructokinase 0.003 0.015 0.0121
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0084 0.0063
Leishmania major glucose transporter, lmgt1 0.0069 0.0569 0.5379
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1401 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0102 0.0213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0355 0.0403
Schistosoma mansoni phd/f-box containing protein 0.0072 0.0602 0.0683
Echinococcus granulosus lysyl tRNA synthetase 0.005 0.0361 0.041
Echinococcus granulosus General substrate transporter 0.0191 0.1886 0.2141
Schistosoma mansoni importin beta-1 0.0035 0.0201 0.0229
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0355 0.0741
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0569 0.5379
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0163 0.1026
Toxoplasma gondii sugar transporter ST1 0.0031 0.0163 0.0141
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0506 0.0574
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0072 0.0602 0.5709
Brugia malayi jmjC domain containing protein 0.0072 0.0602 0.0782
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0163 0.0212
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0049 0.0355 0.0403
Echinococcus granulosus hypothetical protein 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0035 0.0201 0.042
Entamoeba histolytica hypothetical protein 0.0024 0.0084 0.015
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0355 0.0403
Schistosoma mansoni zinc finger protein 0.0022 0.0063 0.0072
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0071 0.0049
Brugia malayi hypothetical protein 0.0049 0.0355 0.0461
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Toxoplasma gondii PHD-finger domain-containing protein 0.0073 0.0612 0.0829
Onchocerca volvulus 0.0049 0.0355 0.0578
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0569 0.5379
Echinococcus granulosus dna polymerase kappa 0.002 0.0039 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.056 0.0636
Plasmodium falciparum proline--tRNA ligase 0.0078 0.0664 0.0644
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0163 0.0412
Echinococcus granulosus 7TM GPCR rhodopsin 0.0049 0.0355 0.0403
Brugia malayi RE15519p 0.0049 0.0355 0.0461
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0084 0.0527
Echinococcus granulosus solute carrier family 22 0.0031 0.0163 0.0185
Loa Loa (eye worm) runx1 0.0057 0.0439 0.0916
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0049 0.0355 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.015 0.0129
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0222 0.2223 0.2524
Giardia lamblia Sugar-proton symporter 0.0031 0.0163 0.0412
Brugia malayi major facilitator superfamily protein 0.0031 0.0163 0.0212
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.015 0.3785
Echinococcus granulosus somatostatin receptor 0.0049 0.0355 0.0403
Schistosoma mansoni myosin xvIII 0.0049 0.0355 0.0403
Plasmodium vivax calcium-dependent protein kinase, putative 0.0068 0.056 0.054
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0163 0.1259
Loa Loa (eye worm) hypothetical protein 0.0453 0.4712 0.9838
Onchocerca volvulus 0.0049 0.0355 0.0578
Schistosoma mansoni jumonji domain containing protein 0.0072 0.0602 0.0683
Echinococcus multilocularis phd:f box containing protein 0.0072 0.0602 0.0683
Trichomonas vaginalis ran, putative 0.0026 0.0102 0.021
Plasmodium vivax CDK-related protein kinase 6, putative 0.0944 1 1
Brugia malayi hypothetical protein 0.0049 0.0355 0.0461
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Schistosoma mansoni protein kinase 0.0068 0.056 0.0636
Echinococcus multilocularis g-protein coupled receptor 0.0049 0.0355 0.0403
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.515 0.5847
Plasmodium falciparum lysine--tRNA ligase 0.005 0.0361 0.034
Trypanosoma brucei glucose transporter, putative 0.0069 0.0569 0.5379
Plasmodium vivax importin-beta 2, putative 0.0035 0.0201 0.018
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0359 0.3699 0.5559
Plasmodium falciparum calcium-dependent protein kinase 4 0.0068 0.056 0.054
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0163 0.0142
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.056 0.0636
Schistosoma mansoni neuropeptide receptor 0.0049 0.0355 0.0403
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0067 0.0545 0.0619
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 0.0479
Onchocerca volvulus Neuropeptide F receptor homolog 0.0049 0.0355 0.0578
Schistosoma mansoni opsin-like receptor 0.0049 0.0355 0.0403
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.0493
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1025 0.1164
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0071 0.0323
Brugia malayi Importin beta-1 subunit 0.0035 0.0201 0.0261
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1025 0.3275
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0355 0.0403
Schistosoma mansoni amine GPCR 0.0049 0.0355 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Brugia malayi PHD-finger family protein 0.0223 0.223 0.2896
Loa Loa (eye worm) hypothetical protein 0.0039 0.0249 0.052
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.305 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Echinococcus granulosus phd:f box containing protein 0.0072 0.0602 0.0683
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0049 0.0355 0.0403
Echinococcus multilocularis serotonin receptor 0.0049 0.0355 0.0403
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0073 0.0612 0.5808
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0114
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0042 0.0281 0.0587
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0163 0.0212
Onchocerca volvulus 0.0049 0.0355 0.0578
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.305 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0021 0.0077
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0067 0.0545 0.0619
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0071 0.0358
Echinococcus granulosus g protein coupled receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0067 0.0545 0.1138
Schistosoma mansoni sugar transporter 0.0031 0.0163 0.0185
Schistosoma mansoni metabotropic glutamate receptor 0.008 0.0692 0.0785
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0355 0.0403
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0072 0.0602 0.5709
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.013 0.0304
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0355 0.0403
Schistosoma mansoni hypothetical protein 0.0222 0.2223 0.2524
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8808 1
Echinococcus multilocularis lysine specific demethylase 5A 0.027 0.2736 0.3106
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0071 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0022 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0355 0.0403
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0569 0.5379
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.0163 1
Onchocerca volvulus 0.0031 0.0163 0.0163
Onchocerca volvulus 0.0049 0.0355 0.0578
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Schistosoma mansoni biogenic amine receptor 0.0049 0.0355 0.0403
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0355 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Brugia malayi AKH receptor 0.0049 0.0355 0.0461
Loa Loa (eye worm) hypothetical protein 0.0054 0.041 0.0857
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0049 0.0355 0.0461
Schistosoma mansoni survival motor neuron protein 0.0058 0.0454 0.0515
Brugia malayi Sugar transporter family protein 0.0222 0.2223 0.2887
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0027 0.0114 0.0148
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0163 0.0412
Schistosoma mansoni opsin-like receptor 0.0049 0.0355 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Schistosoma mansoni growth hormone secretagogue receptor 0.0049 0.0355 0.0403
Echinococcus granulosus orexin receptor type 2 0.0049 0.0355 0.0403
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0664 0.6341
Brugia malayi Dopamine receptor protein 1 0.0049 0.0355 0.0461
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0102 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.2223 0.7253
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Onchocerca volvulus 0.0049 0.0355 0.0578
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0163 0.1259
Brugia malayi Tachykinin-like peptides receptor 99D 0.0049 0.0355 0.0461
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0222 0.0252
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0163 0.1026
Echinococcus granulosus neuropeptide FF receptor 2 0.0049 0.0355 0.0403
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0088 0.0162
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0202 0.0262
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0222 0.2223 0.2524
Brugia malayi ORL1-like opioid receptor 0.0049 0.0355 0.0461
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0084 0.1428
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0049 0.0355 0.0741
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0071 0.0323
Brugia malayi F/Y-rich N-terminus family protein 0.0085 0.0747 0.097
Trypanosoma brucei glucose transporter, putative 0.0069 0.0569 0.5379
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Toxoplasma gondii lysine-tRNA ligase 0.005 0.0361 0.0445
Schistosoma mansoni cpg binding protein 0.0039 0.0242 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0569 0.1762
Echinococcus multilocularis neuropeptide s receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0355 0.0403
Echinococcus granulosus g protein coupled receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0361 0.2462
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0355 0.0403
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1401 1
Brugia malayi jmjC domain containing protein 0.0731 0.77 1
Giardia lamblia Lysyl-tRNA synthetase 0.005 0.0361 0.107
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0088 0.0479
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.015 0.0129
Echinococcus granulosus JmjC domain containing protein 4 0.0072 0.0602 0.0683
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0163 0.034
Onchocerca volvulus 0.0035 0.02 0.0243
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0602 0.1257
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0047
Schistosoma mansoni jumonji domain containing protein 0.058 0.6082 0.6904
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0071 0.0323
Echinococcus granulosus importin subunit beta 1 0.0035 0.0201 0.0229
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Schistosoma mansoni neuropeptide f receptor 76f 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0035 0.0202 0.0422
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0355 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0163 0.0412
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0071 0.0148
Brugia malayi hypothetical protein 0.0049 0.0355 0.0461
Echinococcus multilocularis orexin receptor type 2 0.0049 0.0355 0.0403
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0049 0.0355 0.0741
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0024 0.008 0.0425
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2904 0.3297
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0203 0.2012 0.2285
Brugia malayi Cam kinase protein 1 0.0068 0.056 0.0727
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0355 0.0403
Schistosoma mansoni glucose transporter 0.0031 0.0163 0.0185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0355 0.0403
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.015 0.0369
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0049 0.0355 0.0403
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0049 0.0355 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0163 0.0412
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.015 0.3785
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0361 0.2462
Onchocerca volvulus Huntingtin homolog 0.0125 0.1178 0.2357
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0102 0.0116
Brugia malayi PHD-finger family protein 0.0077 0.0654 0.085
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.056 0.0636
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0078 0.0664 0.0909
Plasmodium falciparum JmjC domain-containing protein, putative 0.0072 0.0602 0.0582
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0049 0.0355 0.0403
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0049 0.0355 0.0403
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Echinococcus granulosus metabotropic glutamate receptor 2 0.0138 0.1314 0.1491
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0039 0.0051
Loa Loa (eye worm) melatonin receptor type 1A 0.0049 0.0355 0.0741
Loa Loa (eye worm) hypothetical protein 0.0042 0.0281 0.0587
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0664 0.6341
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.1025 0.214
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0355 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0088 0.0479
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0743 0.0844
Brugia malayi 6-phosphofructokinase 0.0111 0.1025 0.1331
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.015 0.0369
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0088 0.0162
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.028 0.1491
Onchocerca volvulus 0.0049 0.0355 0.0578
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Onchocerca volvulus 0.0085 0.0743 0.1418
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.1025 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0049 0.0355 0.0741
Brugia malayi hypothetical protein 0.0049 0.0355 0.0461
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.056 0.075
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0743 0.0844
Giardia lamblia Prolyl-tRNA synthetase 0.0067 0.0545 0.1681
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0163 0.0185
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.02 0.0417
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0355 0.0403
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0163 0.1095
Echinococcus multilocularis GPCR, family 3, C terminal 0.0027 0.0114 0.013
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0569 0.5379
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.005 0.0361 0.2104
Brugia malayi lysyl-tRNA synthetase 0.005 0.0361 0.0469
Brugia malayi G-protein coupled receptor 0.0049 0.0355 0.0461
Echinococcus multilocularis sex peptide receptor 0.0049 0.0355 0.0403
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0088 0.0493
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0286 0.2904 0.6063
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.1025 0.1164
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.015 0.0129
Loa Loa (eye worm) PHD-finger family protein 0.0223 0.223 0.4656
Echinococcus granulosus lysine specific demethylase 6a 0.0072 0.0602 0.0683
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0569 0.5379
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0076 0.0644 0.0732
Loa Loa (eye worm) hypothetical protein 0.0085 0.0743 0.1552
Echinococcus granulosus g protein coupled receptor 0.0049 0.0355 0.0403
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.015 0.0369
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0045
Leishmania major GTP-binding protein, putative 0.0026 0.0102 0.0642
Trypanosoma brucei glucose transporter 2A 0.0069 0.0569 0.5379
Giardia lamblia PHD finger protein 15 0.0223 0.223 0.7276
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1025 0.3275
Trypanosoma brucei glucose transporter, putative 0.0069 0.0569 0.5379
Schistosoma mansoni biogenic amine receptor 0.0049 0.0355 0.0403
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0232 0.1962
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0049 0.0355 0.0461
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Schistosoma mansoni sugar transporter 0.0031 0.0163 0.0185
Brugia malayi Dopamine receptor protein 2 0.0049 0.0355 0.0461
Schistosoma mansoni lozenge 0.0057 0.0439 0.0498
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0044 0.0295 0.0851
Brugia malayi Serotonin receptor 0.0049 0.0355 0.0461
Plasmodium falciparum calcium-dependent protein kinase 2 0.0068 0.056 0.054
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0067 0.0545 0.1681
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Schistosoma mansoni ap endonuclease 0.0023 0.0071 0.008
Echinococcus multilocularis solute carrier family 22 0.0031 0.0163 0.0185
Chlamydia trachomatis lysine--tRNA ligase 0.005 0.0361 1
Loa Loa (eye worm) glutamate receptor 0.0065 0.0525 0.1095
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0088 0.0479
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0355 0.0403
Onchocerca volvulus Huntingtin homolog 0.0125 0.1178 0.2357
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0222 0.2223 0.2524
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0071 0.0049
Echinococcus granulosus neuropeptide receptor 0.0049 0.0355 0.0403
Brugia malayi 6-phosphofructokinase 0.0111 0.1025 0.1331
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0045
Onchocerca volvulus 0.0031 0.0163 0.0163
Onchocerca volvulus 0.0031 0.0163 0.0163
Echinococcus multilocularis solute carrier family 22 0.0031 0.0163 0.0185
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0049 0.0355 0.0403
Brugia malayi Metabotropic glutamate receptor precursor. 0.0165 0.1602 0.2081
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0361 0.041
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0039 0.0127
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Leishmania major glucose transporter, lmgt2 0.0069 0.0569 0.5379
Schistosoma mansoni ran 0.0026 0.0102 0.0116
Schistosoma mansoni protein phosphatase 2C 0.0072 0.0602 0.0683
Brugia malayi follicle stimulating hormone receptor 0.0049 0.0355 0.0461
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.1025 0.3275
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.1025 0.7275
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0355 0.0403
Echinococcus multilocularis solute carrier family 22 0.0031 0.0163 0.0185
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3833 0.8002
Loa Loa (eye worm) hypothetical protein 0.0051 0.0376 0.0785
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Loa Loa (eye worm) hypothetical protein 0.0382 0.3948 0.8241
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0125 0.1178 0.2458
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0039 0.0044
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0067 0.0545 0.0619
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0081
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0602 0.1257
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0355 0.0741
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0114
Echinococcus multilocularis zinc finger protein 0.0022 0.0063 0.0072
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0376 0.0785
Onchocerca volvulus 0.0031 0.0163 0.0163
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0039 0.0202
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0075 0.0635 0.0614
Echinococcus granulosus tachykinin peptides receptor 99D 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0361 0.041
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.1025 0.3275
Schistosoma mansoni cpg binding protein 0.0035 0.02 0.0227
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.056 0.0636
Loa Loa (eye worm) jmjC domain-containing protein 0.0461 0.479 1
Plasmodium falciparum hexose transporter 0.0222 0.2223 0.2206
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0031 0.0163 0.034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0355 0.0403
Schistosoma mansoni metabotropic glutamate receptor 0.0138 0.1314 0.1491
Echinococcus granulosus peptide allatostatin:somatostatin 0.0049 0.0355 0.0403
Plasmodium falciparum phd finger protein, putative 0.0223 0.223 0.2213
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0049 0.0355 0.0403
Echinococcus granulosus zinc finger protein 0.0022 0.0063 0.0072
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0355 0.0403
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0068 0.056 0.0636
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0078 0.0664 0.6341
Onchocerca volvulus 0.0453 0.4712 1
Echinococcus multilocularis G protein coupled receptor 139 0.0049 0.0355 0.0403
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0039 0.0202
Echinococcus multilocularis solute carrier family 22 0.0031 0.0163 0.0185
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0067 0.0545 0.1681
Echinococcus multilocularis lysine specific demethylase 6a 0.0072 0.0602 0.0683
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0355 0.0403
Brugia malayi Serotonin receptor 0.0049 0.0355 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0163 0.0412
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0068 0.056 0.1169
Onchocerca volvulus 0.0058 0.0454 0.0792
Loa Loa (eye worm) hypothetical protein 0.0046 0.0318 0.0663
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0049 0.0355 0.0461
Onchocerca volvulus 0.0049 0.0355 0.0578
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.305 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0068 0.056 0.054
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Echinococcus granulosus dnaJ subfamily B 0.0494 0.515 0.5847
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Leishmania major importin beta-1 subunit, putative 0.0028 0.013 0.0927
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.015 0.0121
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0183
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0084 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0569 0.1762
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0039 0.0051
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0355 0.0403
Echinococcus multilocularis allatostatin A receptor 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0045
Schistosoma mansoni amine GPCR 0.0049 0.0355 0.0403
Echinococcus granulosus G protein coupled receptor 139 0.0049 0.0355 0.0403
Loa Loa (eye worm) hypothetical protein 0.0049 0.0355 0.0741
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0355 0.0403
Onchocerca volvulus 0.0049 0.0355 0.0578
Brugia malayi hypothetical protein 0.0286 0.2904 0.3771
Toxoplasma gondii PHD-finger domain-containing protein 0.0223 0.223 0.3308
Plasmodium falciparum protein kinase 7 0.0628 0.6599 0.6591
Echinococcus multilocularis snurportin 1 0.0372 0.3833 0.4351

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0447 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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