Detailed information for compound 1396981

Basic information

Technical information
  • TDR Targets ID: 1396981
  • Name: 2-oxo-2-(2-oxo-1,3-dihydroindol-3-yl)-N-(4-pr opan-2-ylphenyl)acetamide
  • MW: 322.358 | Formula: C19H18N2O3
  • H donors: 2 H acceptors: 3 LogP: 2.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2c(C1C(=O)C(=O)Nc1ccc(cc1)C(C)C)cccc2
  • InChi: 1S/C19H18N2O3/c1-11(2)12-7-9-13(10-8-12)20-19(24)17(22)16-14-5-3-4-6-15(14)21-18(16)23/h3-11,16H,1-2H3,(H,20,24)(H,21,23)
  • InChiKey: VBYKKIZPTRQUGC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(4-isopropylphenyl)-2-oxo-2-(2-oxoindolin-3-yl)acetamide
  • N-(4-isopropylphenyl)-2-oxo-2-(2-oxo-3-indolinyl)acetamide
  • N-(4-isopropylphenyl)-2-keto-2-(2-ketoindolin-3-yl)acetamide
  • 2-oxo-2-(2-oxo-1,3-dihydroindol-3-yl)-N-(4-propan-2-ylphenyl)ethanamide
  • T0503-6943
  • MLS001004692
  • SMR000348212

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Trypanosoma cruzi lanosterol synthase, putative 0.0224 0.0635 0.5373
Entamoeba histolytica hypothetical protein 0.0035 0.0072 0.0562
Brugia malayi beta-lactamase family protein 0.008 0.0206 0.109
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0034 0.0238
Schistosoma mansoni Smad4 0.0018 0.0019 0.0068
Onchocerca volvulus 0.0023 0.0035 0.01
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis snurportin 1 0.0316 0.0908 0.0902
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0046 0.0038
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0091 0.0237 0.0391
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0204 0.081
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0056 0.0196
Echinococcus granulosus geminin 0.0504 0.147 0.5878
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0056 0.0217
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0207 0.0584 0.7387
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0056 0.0049
Schistosoma mansoni chromobox protein 0.0067 0.0167 0.0662
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0014 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0304
Leishmania major hypothetical protein, conserved 0.0016 0.0014 0.006
Loa Loa (eye worm) hypothetical protein 0.0406 0.1177 0.6228
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0079 0.0338
Schistosoma mansoni hypothetical protein 0.003 0.0056 0.0217
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0021 0.0014
Entamoeba histolytica hypothetical protein 0.0035 0.0072 0.0562
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Schistosoma mansoni hypothetical protein 0.0504 0.147 0.5887
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0206 0.1705
Onchocerca volvulus 0.0105 0.0279 0.1237
Loa Loa (eye worm) Smad1 0.0018 0.0019 0.0102
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0052 0.0052
Brugia malayi hypothetical protein 0.0023 0.0035 0.0186
Brugia malayi hypothetical protein 0.002 0.0025 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Brugia malayi RNA, U transporter 1 0.0084 0.0218 0.1152
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0117 0.0617
Echinococcus multilocularis smad 0.0018 0.0019 0.0012
Loa Loa (eye worm) hypothetical protein 0.0182 0.0509 0.2692
Onchocerca volvulus 0.003 0.0056 0.0199
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0117 0.0109
Onchocerca volvulus 0.0734 0.2155 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.006 0.0379
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.006 0.0261
Onchocerca volvulus 0.003 0.0056 0.0199
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Onchocerca volvulus 0.003 0.0056 0.0199
Loa Loa (eye worm) hypothetical protein 0.0039 0.0084 0.0445
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0206 0.0929
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0034 0.0109
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0206 0.0334
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0032 0.0024
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0617
Brugia malayi GnHR receptor homolog 0.003 0.0056 0.0298
Mycobacterium ulcerans hypothetical protein 0.0029 0.0052 0.0052
Schistosoma mansoni zinc finger protein 0.0016 0.0014 0.0045
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0034 0.0238
Mycobacterium tuberculosis Probable oxidoreductase 0.023 0.0653 0.1152
Mycobacterium tuberculosis Probable reductase 0.0207 0.0584 0.1026
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0419
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0186 0.0522 0.4351
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Schistosoma mansoni hypothetical protein 0.005 0.0117 0.0458
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0027 0.0006
Plasmodium falciparum glutathione reductase 0.0091 0.0237 0.1803
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0056 0.0049
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.1177 0.5447
Onchocerca volvulus 0.0029 0.0052 0.0179
Schistosoma mansoni hypothetical protein 0.0109 0.029 0.1156
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0031 0.0012
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0204 0.169
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0186 0.0522 0.2083
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0056 0.0298
Echinococcus granulosus histone lysine methyltransferase setb 0.0111 0.0298 0.1168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.0646 0.2565
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0206 0.0334
Echinococcus granulosus Ankyrin 0.0016 0.0014 0.0027
Schistosoma mansoni biogenic amine receptor 0.003 0.0056 0.0217
Brugia malayi Protein kinase domain containing protein 0.0016 0.0014 0.0073
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0041 0.0162
Plasmodium vivax hypothetical protein, conserved 0.008 0.0206 0.1629
Echinococcus multilocularis geminin 0.0504 0.147 0.1464
Schistosoma mansoni adenoreceptor 0.003 0.0056 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155
Echinococcus multilocularis zinc finger protein 0.0023 0.0037 0.0029
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0016 0.0008
Echinococcus granulosus g protein coupled receptor 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0056 0.0049
Echinococcus granulosus microtubule associated protein 2 0.0833 0.245 0.9818
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0057 0.0435
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0019 0.0068
Loa Loa (eye worm) hypothetical protein 0.0111 0.0298 0.1577
Echinococcus granulosus tm gpcr rhodopsin 0.0532 0.1552 0.6208
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0052 0.0052
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0032 0.0168
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0056 0.0217
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0326 0.0938 0.1676
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0056 0.0049
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0056 0.0049
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0034 0.0238
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0354 0.1408
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0204 0.169
Schistosoma mansoni bromodomain containing protein 0.0068 0.017 0.0674
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0228 0.0646 0.3418
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Leishmania major UDP-galactopyranose mutase 0.0023 0.0035 0.0245
Trypanosoma cruzi trypanothione reductase, putative 0.0091 0.0237 0.1971
Brugia malayi hypothetical protein 0.0035 0.0072 0.0383
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0038 0.0148
Echinococcus granulosus dnaJ subfamily B 0.0849 0.2496 1
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0045
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0056 0.0217
Mycobacterium tuberculosis Conserved protein 0.008 0.0206 0.0334
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0036 0.0188
Toxoplasma gondii thioredoxin reductase 0.0091 0.0237 0.1902
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0056 0.0217
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0105 0.0279 0.1108
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.006 0.0461
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0032 0.0024
Brugia malayi G protein-coupled receptor 0.003 0.0056 0.0298
Schistosoma mansoni smad1 5 8 and 0.0018 0.0019 0.0068
Echinococcus granulosus orexin receptor type 2 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi amine oxidase, flavin-containing family protein 0.0023 0.0035 0.0186
Schistosoma mansoni hypothetical protein 0.0849 0.2496 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Trypanosoma cruzi lanosterol synthase, putative 0.0224 0.0635 0.5373
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0167 0.0886
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0167 0.0749
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus granulosus neuropeptide receptor 0.003 0.0056 0.0196
Schistosoma mansoni opsin-like receptor 0.003 0.0056 0.0217
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0406 0.1177 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.0047 0.0107 0.0568
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.006 0.0053
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0056 0.0049
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0088 0.0378
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0031 0.0012
Onchocerca volvulus 0.003 0.0056 0.0199
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0041 0.0034
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0204 0.0197
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0019 0.0047
Onchocerca volvulus 0.008 0.0206 0.0898
Schistosoma mansoni hypothetical protein 0.003 0.0056 0.0217
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0056 0.0217
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0021 0.0054
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0144 0.0764
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0056 0.0217
Trichomonas vaginalis set domain proteins, putative 0.0734 0.2155 1
Schistosoma mansoni smad1 5 8 and 0.0018 0.0019 0.0068
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0276
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0019 0.0066
Schistosoma mansoni histamine h1 receptor 0.003 0.0056 0.0217
Schistosoma mansoni hypothetical protein 0.0014 0.0007 0.002
Schistosoma mansoni neuropeptide receptor 0.003 0.0056 0.0217
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0406 0.1177 0.4699
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0056 0.0217
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0356 0.1027 0.5435
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0206 0.0929
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0056 0.0217
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0056 0.0196
Toxoplasma gondii ABC1 family protein 0.008 0.0206 0.1633
Schistosoma mansoni ran 0.0022 0.0032 0.0118
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0057 0.0348
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0167 0.0749
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.245 0.9818
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.044 0.233
Leishmania major GTP-binding protein, putative 0.0022 0.0032 0.0215
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0056 0.0196
Schistosoma mansoni hypothetical protein 0.005 0.0117 0.0458
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0034 0.013
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0056 0.0049
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0027 0.0046 0.0254
Echinococcus granulosus somatostatin receptor 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0046
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0056 0.0049
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.006 0.0461
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.185 0.5479 1
Entamoeba histolytica hypothetical protein 0.0035 0.0072 0.0562
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0056 0.0196
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0052 0.0052
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0056 0.0196
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.006 0.0461
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0056 0.0298
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0021 0.0075
Echinococcus granulosus chromobox protein 1 0.0067 0.0167 0.0643
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0104 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0117 0.0617
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0056 0.0196
Echinococcus multilocularis importin subunit beta 1 0.003 0.0055 0.0048
Schistosoma mansoni biogenic amine receptor 0.003 0.0056 0.0217
Brugia malayi SET domain containing protein 0.0016 0.0014 0.0072
Echinococcus multilocularis 0.0023 0.0035 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0057 0.0435
Leishmania major hypothetical protein, conserved 0.003 0.0057 0.0435
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0167 0.064
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0406 0.1177 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0204 0.0791
Schistosoma mansoni P2X receptor subunit 0.0067 0.0167 0.0659
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0036 0.0188
Toxoplasma gondii exonuclease III APE 0.0023 0.0034 0.0154
Schistosoma mansoni smad 0.0018 0.0019 0.0068
Entamoeba histolytica hypothetical protein 0.0024 0.0038 0.0271
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.004 0.0155
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0056 0.0196
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0016 0.0033
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0186 0.0522 0.2761
Echinococcus granulosus g protein coupled receptor 0.0274 0.0783 0.3117
Plasmodium vivax importin-beta 2, putative 0.003 0.0055 0.0326
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis thioredoxin glutathione reductase 0.0091 0.0239 0.0231
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.023 0.0653 0.1152
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0056 0.0298
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0037 0.0196
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0088 0.0345
Echinococcus multilocularis cpg binding protein 0.0065 0.016 0.0153
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0056 0.0049
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0291
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Echinococcus granulosus importin subunit beta 1 0.003 0.0055 0.0191
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0021 0.0014
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0056 0.0049
Brugia malayi beta-lactamase family protein 0.008 0.0206 0.109
Brugia malayi neuropeptide F receptor 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus granulosus g-protein coupled receptor 0.003 0.0056 0.0196
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0014 0.0026
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.006 0.0374
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.006 0.0461
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.245 0.2445
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.0056 0.0199
Schistosoma mansoni amine GPCR 0.003 0.0056 0.0217
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.185 0.5479 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0645 0.1889 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0532 0.1552 0.1546
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0406 0.1177 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0056 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0079 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Trypanosoma brucei C-8 sterol isomerase, putative 0.0356 0.1027 0.8721
Entamoeba histolytica hypothetical protein 0.0035 0.0072 0.0562
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0056 0.0298
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0026 0.0093
Onchocerca volvulus 0.003 0.0056 0.0199
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0056 0.0298
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0057 0.0353
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0038 0.0271
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0206 0.0929
Onchocerca volvulus 0.0274 0.0783 0.3593
Trypanosoma cruzi ISWI complex protein 0.0016 0.0014 0.006
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0014 0.0048
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0276
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0019 0.0011
Mycobacterium ulcerans monoamine oxidase 0.0023 0.0035 0.0021
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0208 0.0805
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0056 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0206 0.0929
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0072 0.0261
Plasmodium falciparum phenylalanine--tRNA ligase 0.0153 0.0423 0.3424
Brugia malayi beta-lactamase 0.008 0.0206 0.109
Echinococcus multilocularis dnaJ subfamily B 0.0849 0.2496 0.249
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0057 0.0435
Onchocerca volvulus 0.003 0.0055 0.0192
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0056 0.0196
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0406 0.1177 0.117
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0041 0.0218
Echinococcus granulosus allatostatin A receptor 0.003 0.0056 0.0196
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0056 0.0217
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0162
Echinococcus granulosus chromobox protein 1 0.0067 0.0167 0.0643
Echinococcus multilocularis g protein coupled receptor 0.0274 0.0783 0.0776
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Brugia malayi MH2 domain containing protein 0.0018 0.0019 0.0102
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0406 0.1177 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0056 0.0196
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0088 0.0378
Echinococcus granulosus snurportin 1 0.0316 0.0908 0.3621
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0056 0.0049
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0167 0.0159
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0056 0.0298
Echinococcus granulosus neuropeptide s receptor 0.003 0.0056 0.0196
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0056 0.0196
Brugia malayi G-protein coupled receptor 0.003 0.0056 0.0298
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0034 0.0034
Brugia malayi Melatonin receptor type 1A 0.003 0.0056 0.0298
Onchocerca volvulus 0.003 0.0056 0.0199
Echinococcus granulosus zinc finger protein 0.0023 0.0037 0.0118
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.006 0.0067
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0206 0.0334
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0134 0.0366 0.3006
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0056 0.0196
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0056 0.0217
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0072 0.0281
Leishmania major hypothetical protein, conserved 0.008 0.0206 0.1705
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0032 0.0131
Loa Loa (eye worm) thioredoxin reductase 0.0091 0.0237 0.1255
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0046 0.0174
Echinococcus multilocularis allatostatin A receptor 0.003 0.0056 0.0049
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0056 0.0196
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0186 0.0522 0.2067
Onchocerca volvulus 0.003 0.0056 0.0199
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus granulosus 7tm_1 domain containing protein 0.0304 0.0873 0.3477
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0052 0.0389
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0056 0.0298
Schistosoma mansoni hypothetical protein 0.0021 0.003 0.011
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0023 0.0035 0.0132
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0056 0.0196
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0056 0.0298
Echinococcus granulosus bloom syndrome protein 0.0025 0.0041 0.0136
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0484
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.0056 0.0199
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0019 0.0102
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0207 0.0584 0.1026
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0052 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Echinococcus multilocularis Ankyrin 0.0016 0.0014 0.0007
Mycobacterium leprae Probable lipase LipE 0.008 0.0206 0.2301
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0117 0.0439
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0073
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0032 0.0215
Leishmania major lanosterol synthase, putative 0.0224 0.0635 0.5373
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0056 0.0196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.0646 0.0639
Loa Loa (eye worm) MH2 domain-containing protein 0.0258 0.0736 0.3896
Mycobacterium ulcerans oxidoreductase 0.0023 0.0035 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0298 0.1186
Echinococcus granulosus sex peptide receptor 0.003 0.0056 0.0196
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0056 0.0196
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0038 0.0148
Mycobacterium ulcerans hypothetical protein 0.008 0.0206 0.0334
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0206 0.0199
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0035 0.0245
Schistosoma mansoni amine GPCR 0.003 0.0056 0.0217
Schistosoma mansoni opsin-like receptor 0.003 0.0056 0.0217
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0052 0.0052
Mycobacterium ulcerans beta-lactamase 0.008 0.0206 0.0334
Loa Loa (eye worm) hypothetical protein 0.0073 0.0183 0.0969
Echinococcus granulosus smad 0.0018 0.0019 0.0047
Brugia malayi PHD-finger family protein 0.0029 0.0053 0.0281
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0055 0.0414
Schistosoma mansoni hypothetical protein 0.0316 0.0908 0.3634
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0034 0.0238
Schistosoma mansoni neuropeptide receptor 0.003 0.0056 0.0217
Echinococcus multilocularis chromobox protein 1 0.0067 0.0167 0.016
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.0809 0.4281
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0023 0.0035 0.0028
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0014 0.0006
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0035 0.0041
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0134 0.0366 0.1457
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Brugia malayi Importin beta-1 subunit 0.003 0.0055 0.0291
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi Thioredoxin reductase 0.0091 0.0237 0.1255
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0406 0.1177 0.471
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0504 0.147 0.5887
Brugia malayi MH2 domain containing protein 0.0258 0.0736 0.3896
Leishmania major C-8 sterol isomerase-like protein 0.0356 0.1027 0.8721
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0052 0.0389
Onchocerca volvulus 0.003 0.0056 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.0159 0.044 0.233
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0206 0.0334
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0167 0.0159
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0056 0.0298
Schistosoma mansoni hypothetical protein 0.0035 0.0072 0.0281
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.044 0.233
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0206 0.0929
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0149 0.0411 0.071
Brugia malayi Pre-SET motif family protein 0.0094 0.0246 0.1301
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi Latrophilin receptor protein 2 0.005 0.0117 0.0617
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0032 0.0215
Brugia malayi sulfakinin receptor protein 0.003 0.0056 0.0298
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0207 0.0584 0.1026
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis orexin receptor type 2 0.003 0.0056 0.0049
Schistosoma mansoni amine GPCR 0.003 0.0056 0.0217
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0052 0.0052
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0052 0.0389
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0406 0.1177 1
Brugia malayi Serotonin receptor 0.0474 0.1381 0.7309
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0031 0.006 0.0067
Schistosoma mansoni neuropeptide receptor 0.003 0.0056 0.0217
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0079 0.0305
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0018 0.0054
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.003 0.0158
Loa Loa (eye worm) hypothetical protein 0.0126 0.0342 0.1808
Brugia malayi Serotonin receptor 0.003 0.0056 0.0298
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0019 0.0012
Echinococcus multilocularis serotonin receptor 0.003 0.0056 0.0049
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0276
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Echinococcus granulosus GPCR family 2 0.005 0.0117 0.0439
Mycobacterium ulcerans dehydrogenase 0.0023 0.0035 0.0021
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0206 0.109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.0646 0.258
Onchocerca volvulus 0.008 0.0206 0.0898
Onchocerca volvulus 0.003 0.0056 0.0199
Schistosoma mansoni netrin receptor unc5 0.0016 0.0014 0.0046
Schistosoma mansoni P2X receptor subunit 0.0067 0.0167 0.0659
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0034 0.0019
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0056 0.0217
Onchocerca volvulus 0.006 0.0144 0.061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0027 0.0006
Brugia malayi G-protein coupled receptor 0.003 0.0056 0.0298
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Mycobacterium tuberculosis Possible oxidoreductase 0.0023 0.0035 0.0021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.0321 0.262
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0046 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0046 0.0185
Echinococcus multilocularis fmrfamide receptor 0.003 0.0056 0.0049
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0206 0.1705
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0167 0.0159
Plasmodium falciparum thioredoxin reductase 0.0091 0.0237 0.1803
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0032 0.0168
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0513 0.1495 0.2697
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0056 0.0298
Loa Loa (eye worm) beta-lactamase 0.008 0.0206 0.109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0246 0.0977
Entamoeba histolytica Ran family GTPase 0.0022 0.0032 0.0215
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.016 0.0611
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0204 0.1082
Brugia malayi Bromodomain containing protein 0.008 0.0206 0.1092
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0031 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0162
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0057 0.0235
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0034 0.0182
Schistosoma mansoni neuropeptide receptor 0.003 0.0056 0.0217
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0056 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.0646 0.258
Brugia malayi Smad1 0.0018 0.0019 0.0102
Brugia malayi RE15519p 0.003 0.0056 0.0298
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0056 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0052 0.0389
Echinococcus granulosus hypothetical protein 0.003 0.0056 0.0196
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0023 0.0035 0.0021
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0167 0.064
Brugia malayi Heterochromatin protein 1 0.0067 0.0167 0.0886
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0014 0.0026
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.0908 0.4808
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0031 0.006 0.0067
Echinococcus multilocularis sex peptide receptor 0.003 0.0056 0.0049
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0014 0.0046
Brugia malayi Pre-SET motif family protein 0.0645 0.1889 1
Trichomonas vaginalis esterase, putative 0.008 0.0206 0.0929
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0019 0.0047
Loa Loa (eye worm) hypothetical protein 0.0274 0.0783 0.4145
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.006 0.0461
Loa Loa (eye worm) hypothetical protein 0.0356 0.1027 0.5435
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0056 0.0217
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0056 0.0049
Brugia malayi Dopamine receptor 0.003 0.0056 0.0298
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0032 0.0098
Brugia malayi MH2 domain containing protein 0.0018 0.0019 0.0102
Brugia malayi Dopamine receptor protein 1 0.003 0.0056 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.006 0.0233
Echinococcus multilocularis fmrfamide receptor 0.003 0.0056 0.0049
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.023 0.0653 0.1152
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.0109 0.029 0.1537
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0232 0.0902
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0056 0.0049
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0246 0.1977
Plasmodium vivax glutathione reductase, putative 0.0091 0.0237 0.1898
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0056 0.0049
Mycobacterium leprae conserved hypothetical protein 0.008 0.0206 0.2301
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0019 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi ORL1-like opioid receptor 0.003 0.0056 0.0298
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0016 0.0053
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0041 0.0162
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) glutathione reductase 0.0091 0.0237 0.1255
Echinococcus multilocularis Smad4 0.0018 0.0019 0.0012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0077 0.0278
Echinococcus multilocularis serotonin receptor 0.003 0.0056 0.0049
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Brugia malayi chromobox protein homolog 3 0.0038 0.0079 0.0419
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0206 0.0334
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0035 0.0245
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0356 0.1027 0.8721
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0167 0.064
Echinococcus granulosus serotonin receptor 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0303 0.087 0.1551
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0056 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0204 0.169
Schistosoma mansoni opsin-like receptor 0.003 0.0056 0.0217
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0056 0.0217
Plasmodium vivax thioredoxin reductase, putative 0.0091 0.0237 0.1898
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0206 0.0334
Onchocerca volvulus 0.003 0.0056 0.0199
Mycobacterium tuberculosis Conserved protein 0.008 0.0206 0.0334
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0052 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0019 0.0102
Trypanosoma brucei lanosterol synthase 0.0224 0.0635 0.5373
Echinococcus granulosus neuropeptide receptor 0.003 0.0056 0.0196
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0056 0.0049
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0014 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0032 0.0097
Plasmodium falciparum importin beta, putative 0.003 0.0055 0.0213
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0056 0.0298
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0052 0.0228
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0035 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0298 0.1186
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0206 0.0798
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.023 0.0653 0.8314
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0204 0.1082
Chlamydia trachomatis protoporphyrinogen oxidase 0.0023 0.0035 0.0021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0035 0.0021
Mycobacterium ulcerans lipase LipD 0.008 0.0206 0.0334
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.044 0.233
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.006 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Echinococcus multilocularis neuropeptide receptor 0.003 0.0056 0.0049
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0032 0.0168
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0056 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0046 0.0185
Brugia malayi Death domain containing protein 0.0016 0.0014 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0056 0.0196
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.006 0.0251
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0056 0.0217
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0056 0.0217
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Plasmodium falciparum protoporphyrinogen oxidase 0.0023 0.0035 0.0041
Brugia malayi CXXC zinc finger family protein 0.006 0.0144 0.0764
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0056 0.0298
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0186 0.0522 0.4354
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0032 0.0215
Plasmodium vivax SET domain protein, putative 0.0094 0.0246 0.1973
Trypanosoma cruzi ISWI complex protein 0.0016 0.0014 0.006
Brugia malayi putative neuropeptide receptor 0.003 0.0056 0.0298
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0055 0.0414
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0031 0.006 0.0067
Schistosoma mansoni ran 0.0022 0.0032 0.0118
Brugia malayi MH1 domain containing protein 0.0018 0.0019 0.0102
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0204 0.169
Schistosoma mansoni hypothetical protein 0.005 0.0117 0.0458
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0162
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0075
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0031 0.0116
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.1177 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0027 0.0006
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0032 0.0015
Schistosoma mansoni P2X receptor subunit 0.0067 0.0167 0.0659
Plasmodium falciparum glutathione reductase 0.0031 0.006 0.0261
Loa Loa (eye worm) transcription factor SMAD2 0.0258 0.0736 0.3896
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.006 0.0374
Schistosoma mansoni hypothetical protein 0.003 0.0056 0.0217
Giardia lamblia NADH oxidase lateral transfer candidate 0.0031 0.006 0.0251
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.006 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Toxoplasma gondii histone lysine-specific demethylase 0.0023 0.0035 0.0161
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0023 0.0035 0.0156
Schistosoma mansoni cpg binding protein 0.0065 0.016 0.0633
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0056 0.0217
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.006 0.0213
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0406 0.1177 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0034 0.0149
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.006 0.0067
Schistosoma mansoni amine oxidase 0.0023 0.0035 0.0132
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0031 0.006 0.0067
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0291
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.016 0.0152
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0207 0.0584 0.1026
Onchocerca volvulus 0.003 0.0056 0.0199
Onchocerca volvulus 0.003 0.0056 0.0199
Mycobacterium tuberculosis Conserved protein 0.008 0.0206 0.0334
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0206 0.0334
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0186 0.0522 0.2761
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0032 0.0126
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Schistosoma mansoni hypothetical protein 0.005 0.0117 0.0458
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0019 0.0066
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0056 0.0217
Trichomonas vaginalis ran, putative 0.0022 0.0032 0.0117
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0204 0.169
Loa Loa (eye worm) RecQ helicase 0.0025 0.0041 0.0218
Echinococcus multilocularis somatostatin receptor 0.003 0.0056 0.0049
Onchocerca volvulus 0.003 0.0056 0.0199
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0206 0.109
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.185 0.5479 1
Treponema pallidum NADH oxidase 0.0031 0.006 0.0228
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0056 0.0049
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0034 0.0027
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0326 0.0938 0.1676
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0056 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.006 0.0261
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0035 0.0156
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Brugia malayi glutathione reductase 0.0091 0.0237 0.1255
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0021 0.0068
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0034 0.0238
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0021 0.011
Brugia malayi hypothetical protein 0.003 0.0057 0.0304
Mycobacterium tuberculosis Probable dehydrogenase 0.0207 0.0584 0.1026
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0077 0.0069
Echinococcus multilocularis g protein coupled receptor 0.003 0.0056 0.0049
Brugia malayi MH1 domain containing protein 0.0018 0.0019 0.0102
Echinococcus granulosus g protein coupled receptor 0.003 0.0056 0.0196
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0117 0.0109
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0134 0.0366 0.1672
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0056 0.0049
Echinococcus granulosus death domain containing protein 0.0016 0.0014 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0034 0.0019
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.1177 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0052 0.0052
Schistosoma mansoni smad1 5 8 and 0.0018 0.0019 0.0068
Schistosoma mansoni chromobox protein 0.0067 0.0167 0.0662
Onchocerca volvulus 0.003 0.0056 0.0199
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0406 0.1177 0.6228
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0034 0.0019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0246 0.0239
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Schistosoma mansoni ap endonuclease 0.0023 0.0034 0.0129
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.006 0.032
Brugia malayi neuropeptide F receptor 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0206 0.1705
Trichomonas vaginalis helicase, putative 0.0013 0.0007 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0206 0.0817
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0019 0.0012
Schistosoma mansoni ap endonuclease 0.0023 0.0034 0.0129
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0272 0.0778 1
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0104 0.0389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0072 0.0065
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0035 0.0111
Brugia malayi Dopamine receptor protein 2 0.003 0.0056 0.0298
Echinococcus multilocularis chromobox protein 1 0.0067 0.0167 0.016
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.0646 0.2565
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0052 0.0389
Echinococcus granulosus fmrfamide receptor 0.003 0.0056 0.0196
Schistosoma mansoni myosin xvIII 0.003 0.0056 0.0217
Brugia malayi Bromodomain containing protein 0.0039 0.0084 0.0444
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0057 0.0235
Leishmania major importin beta-1 subunit, putative 0.0024 0.0038 0.0271
Chlamydia trachomatis phenylalanine--tRNA ligase subunit alpha 0.185 0.5479 1
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0186 0.0522 0.0515
Echinococcus multilocularis GPCR, family 2 0.005 0.0117 0.0109
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Echinococcus granulosus Smad4 0.0018 0.0019 0.0047
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0056 0.0196
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0134 0.0366 0.1672
Plasmodium falciparum thioredoxin reductase 0.0031 0.006 0.0261
Onchocerca volvulus 0.003 0.0056 0.0199
Schistosoma mansoni cpg binding protein 0.0065 0.016 0.0633
Schistosoma mansoni hypothetical protein 0.003 0.0056 0.0217
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0014 0.0073
Brugia malayi CHD4 protein 0.0016 0.0016 0.0082
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0023 0.0035 0.0041
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0206 0.0334
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.004 0.0155
Schistosoma mansoni amine GPCR 0.003 0.0056 0.0217
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0032 0.001
Brugia malayi larval opioid receptor 0.003 0.0056 0.0298
Brugia malayi follicle stimulating hormone receptor 0.0283 0.0809 0.4281
Schistosoma mansoni cpg binding protein 0.006 0.0144 0.0569
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.029 0.1537
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0052 0.0276
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0056 0.0298
Onchocerca volvulus 0.008 0.0206 0.0898
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0228 0.0646 0.3418
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0052 0.0389
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0023 0.0035 0.0156
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0052 0.0276
Schistosoma mansoni zinc finger protein 0.0023 0.0037 0.0138
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0035 0.0156
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0034 0.013
Brugia malayi Uncoordinated protein 44 0.0016 0.0014 0.0073
Schistosoma mansoni amine GPCR 0.003 0.0056 0.0217
Onchocerca volvulus 0.003 0.0056 0.0199
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0034 0.0024
Echinococcus multilocularis g protein coupled receptor 0.003 0.0056 0.0049
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0027 0.0006
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0055 0.0331
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0056 0.0217
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0056 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.0646 0.258
Schistosoma mansoni amine oxidase 0.0023 0.0035 0.0132
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.1177 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.006 0.0461
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.006 0.0461
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0208 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0021 0.0068
Leishmania major trypanothione reductase 0.0091 0.0237 0.1971
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.006 0.0379
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Trypanosoma brucei ISWI complex protein 0.0016 0.0014 0.006
Echinococcus granulosus cpg binding protein 0.0065 0.016 0.0614
Echinococcus multilocularis g protein coupled receptor 0.003 0.0056 0.0049
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0117 0.0439
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0031 0.006 0.0067
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0207 0.0584 0.1026
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0052 0.0052
Schistosoma mansoni importin beta-1 0.003 0.0055 0.0211
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0056 0.0298
Plasmodium falciparum phenylalanine--tRNA ligase 0.0186 0.0522 0.4285
Onchocerca volvulus 0.003 0.0056 0.0199
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0206 0.0817
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0038 0.0148
Schistosoma mansoni P2X receptor subunit 0.0067 0.0167 0.0659
Echinococcus granulosus thioredoxin glutathione reductase 0.0091 0.0239 0.093
Schistosoma mansoni biogenic amine receptor 0.003 0.0056 0.0217
Echinococcus multilocularis protoporphyrinogen oxidase 0.0023 0.0035 0.0028
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0023 0.0035 0.0132
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0111 0.0298 0.0291
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0016 0.0082
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.006 0.0251
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0052 0.0228
Brugia malayi SWIRM domain containing protein 0.0023 0.0035 0.0186
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0056 0.0049
Echinococcus multilocularis neuropeptide receptor 0.003 0.0056 0.0049
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0034 0.0182
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0056 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.0646 0.0639
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0206 0.0334
Trypanosoma brucei trypanothione reductase 0.0091 0.0237 0.1971
Brugia malayi AKH receptor 0.003 0.0056 0.0298
Echinococcus granulosus g protein coupled receptor 0.003 0.0056 0.0196
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 98.23 uM PubChem BioAssay. Fluorescence polarization aasay to screen for inhibitors that compete for the binding of FadD28 to a bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.3582 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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