Detailed information for compound 1405938

Basic information

Technical information
  • TDR Targets ID: 1405938
  • Name: 1,3-diethyl-5-[[(4-morpholin-4-ylphenyl)amino ]methylidene]-2-sulfanylidene-1,3-diazinane-4 ,6-dione
  • MW: 388.484 | Formula: C19H24N4O3S
  • H donors: 1 H acceptors: 2 LogP: 2.11 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1C(=S)N(CC)C(=O)C(=CNc2ccc(cc2)N2CCOCC2)C1=O
  • InChi: 1S/C19H24N4O3S/c1-3-22-17(24)16(18(25)23(4-2)19(22)27)13-20-14-5-7-15(8-6-14)21-9-11-26-12-10-21/h5-8,13,20H,3-4,9-12H2,1-2H3
  • InChiKey: QWQLNHYQRDGGMK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-diethyl-5-[[(4-morpholinophenyl)amino]methylene]-2-thioxo-hexahydropyrimidine-4,6-dione
  • 1,3-diethyl-5-[[(4-morpholinophenyl)amino]methylene]-2-thioxohexahydropyrimidine-4,6-dione
  • 1,3-diethyl-5-[[(4-morpholinophenyl)amino]methylene]-2-thioxo-hexahydropyrimidine-4,6-quinone
  • 1,3-diethyl-5-({[4-(4-morpholinyl)phenyl]amino}methylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
  • MLS000576683
  • SMR000197151
  • ZINC00638479
  • 1,3-diethyl-5-{[4-(4-morpholinyl)anilino]methylene}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
  • AO-081/41132661

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens troponin T type 2 (cardiac) Starlite/ChEMBL No references
Homo sapiens troponin C type 1 (slow) Starlite/ChEMBL No references
Homo sapiens plectin Starlite/ChEMBL No references
Homo sapiens troponin I type 3 (cardiac) Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens tumor susceptibility 101 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_132708 All targets in OG5_132708
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Troponin family protein Get druggable targets OG5_132708 All targets in OG5_132708
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10382 dystonin, putative Get druggable targets OG5_127704 All targets in OG5_127704
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi VAB-10A protein Get druggable targets OG5_127704 All targets in OG5_127704
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127704 All targets in OG5_127704
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) spectraplakin Get druggable targets OG5_127704 All targets in OG5_127704
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, putative Get druggable targets OG5_127704 All targets in OG5_127704
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, putative Get druggable targets OG5_127704 All targets in OG5_127704
Schistosoma japonicum expressed protein Get druggable targets OG5_127704 All targets in OG5_127704
Schistosoma mansoni hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni troponin t invertebrate Get druggable targets OG5_129858 All targets in OG5_129858
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus oncosphere protein Tso22e Get druggable targets OG5_129858 All targets in OG5_129858
Echinococcus multilocularis Spectrin alpha actinin Get druggable targets OG5_127704 All targets in OG5_127704
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative Get druggable targets OG5_128950 All targets in OG5_128950
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Troponin T, skeletal muscle homolog Get druggable targets OG5_129858 All targets in OG5_129858
Onchocerca volvulus Troponin T, skeletal muscle homolog Get druggable targets OG5_129858 All targets in OG5_129858
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi hypothetical protein Get druggable targets OG5_129858 All targets in OG5_129858
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127704 All targets in OG5_127704
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma japonicum IPR001978,Troponin,domain-containing Get druggable targets OG5_132708 All targets in OG5_132708
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum IPR001101,Plectin repeat,domain-containing Get druggable targets OG5_127704 All targets in OG5_127704
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127704 All targets in OG5_127704
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 Get druggable targets OG5_129858 All targets in OG5_129858
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Troponin I 4, putative Get druggable targets OG5_132708 All targets in OG5_132708
Brugia malayi Troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) troponin Get druggable targets OG5_129858 All targets in OG5_129858
Schistosoma japonicum Tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus troponin i Get druggable targets OG5_132708 All targets in OG5_132708
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129858 All targets in OG5_129858
Trypanosoma cruzi kinetoplast DNA-associated protein, putative Get druggable targets OG5_127704 All targets in OG5_127704
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Troponin T, skeletal muscle, putative Get druggable targets OG5_129858 All targets in OG5_129858
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus Spectrin alpha actinin Get druggable targets OG5_127704 All targets in OG5_127704
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127704 All targets in OG5_127704
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum Bullous pemphigoid antigen 1, isoforms 6/7, putative Get druggable targets OG5_127704 All targets in OG5_127704
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Entamoeba histolytica tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Growth-Arrest-Specific Protein 2 Domain containing protein Get druggable targets OG5_127704 All targets in OG5_127704
Echinococcus multilocularis troponin i Get druggable targets OG5_132708 All targets in OG5_132708
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Troponin I homolog Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium falciparum centrin-3 troponin C type 1 (slow) 161 aa 148 aa 33.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0087 0.0086
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.0345 0.0344
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0008 0.0048
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0008 0.0058
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1657 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0087 0.0521
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1015 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0097 0.0148 0.0497
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0027 0.0005 0.0021
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0098 0.0319
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0148 0.0497
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0027 0.016
Plasmodium falciparum importin beta, putative 0.0035 0.0021 0.047
Echinococcus multilocularis Spectrin alpha actinin 0.0043 0.0037 0.0036
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0221 0.0403 0.3309
Schistosoma mansoni hypothetical protein 0.0036 0.0023 0.0135
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0048 0.0286
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1407 0.2832 1
Loa Loa (eye worm) TAR-binding protein 0.0255 0.0473 0.4647
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0124 0.0123
Schistosoma mansoni hypothetical protein 0.0082 0.0117 0.0704
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0221 0.0403 0.0403
Schistosoma mansoni troponin t invertebrate 0.016 0.0278 0.1671
Brugia malayi Troponin family protein 0.0129 0.0214 0.2091
Onchocerca volvulus Huntingtin homolog 0.0124 0.0205 0.3071
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0008 0.0146
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0431 0.2599
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0021 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0008 0.0029
Loa Loa (eye worm) hypothetical protein 0.0097 0.0148 0.1444
Schistosoma mansoni tar DNA-binding protein 0.0255 0.0473 0.2851
Schistosoma mansoni tar DNA-binding protein 0.0255 0.0473 0.2851
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0124 0.0742
Schistosoma mansoni survival motor neuron protein 0.0048 0.0048 0.0285
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1015 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0231 0.1391
Loa Loa (eye worm) hypothetical protein 0.0129 0.0214 0.2091
Echinococcus granulosus Niemann Pick C1 protein 0.0282 0.0528 0.3186
Onchocerca volvulus 0.0048 0.0048 0.0625
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.016 0.0278 0.4206
Entamoeba histolytica hypothetical protein 0.011 0.0176 0.4917
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0008 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1015 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0008 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.009 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.0649 0.6383
Schistosoma mansoni hypothetical protein 0.0043 0.0037 0.0219
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0255 0.0473 0.4647
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0046 0.1253
Loa Loa (eye worm) hypothetical protein 0.0235 0.0431 0.4235
Brugia malayi Growth-Arrest-Specific Protein 2 Domain containing protein 0.0043 0.0037 0.0343
Schistosoma mansoni hypothetical protein 0.0043 0.0037 0.0219
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1407 0.2832 1
Brugia malayi Troponin T 0.0076 0.0106 0.1029
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.0649 0.6383
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0008 0.0146
Leishmania major hypothetical protein, conserved 0.0027 0.0005 0.0021
Echinococcus granulosus Spectrin alpha actinin 0.0043 0.0037 0.022
Echinococcus granulosus expressed conserved protein 0.0186 0.033 0.1989
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.0355 0.2137
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0027 0.0026
Schistosoma mansoni bromodomain containing protein 0.0071 0.0095 0.0568
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0076 0.0106 0.1029
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.0098 0.2393
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0027 0.0005 0.0021
Loa Loa (eye worm) acetyltransferase 0.0178 0.0313 0.3073
Brugia malayi Troponin T 0.0076 0.0106 0.1029
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0008 0.0058
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0221 0.0403 0.2431
Schistosoma mansoni troponin I 0.0129 0.0214 0.1288
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0231 0.023
Loa Loa (eye worm) hypothetical protein 0.0198 0.0355 0.348
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.0355 1
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0098 0.015 0.0503
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0008 0.0045
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.0548 0.4505
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0008 0.0045
Leishmania major mitochondrial DNA polymerase beta 0.0617 0.1215 1
Onchocerca volvulus Glucosylceramidase homolog 0.0341 0.0649 1
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0221 0.0403 0.3961
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0948
Loa Loa (eye worm) hypothetical protein 0.0049 0.005 0.0475
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0231 0.023
Brugia malayi VAB-10A protein 0.0043 0.0037 0.0343
Schistosoma mansoni hypothetical protein 0.0372 0.0711 0.429
Loa Loa (eye worm) hypothetical protein 0.0124 0.0205 0.2
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0048 0.0047
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.016 0.0278 0.0277
Schistosoma mansoni hypothetical protein 0.0048 0.0048 0.0285
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.009 0.0318
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0176 0.0175
Brugia malayi RNA, U transporter 1 0.0099 0.0153 0.1485
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0062 0.0368
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0008 0.0048
Schistosoma mansoni hypothetical protein 0.0082 0.0117 0.0704
Mycobacterium ulcerans TetR family transcriptional regulator 0.1407 0.2832 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.0098 0.0347
Echinococcus multilocularis protein dispatched 1 0.0097 0.0148 0.0147
Brugia malayi RNA binding protein 0.0255 0.0473 0.4647
Brugia malayi hypothetical protein 0.0124 0.0205 0.2
Echinococcus multilocularis protein patched 0.0085 0.0124 0.0123
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0124 0.0742
Loa Loa (eye worm) troponin I 0.0129 0.0214 0.2091
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0221 0.0403 1
Brugia malayi RNA recognition motif domain containing protein 0.0255 0.0473 0.4647
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0948
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.0355 0.0354
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0948
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0058
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1657 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0292 0.0548 0.4505
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0048 0.0451
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0048 0.0047
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0008 0.0048
Plasmodium vivax importin-beta 2, putative 0.0035 0.0021 0.047
Echinococcus granulosus geminin 0.0348 0.0662 0.3993
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0176 0.1056
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0124 0.0203 0.069
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0008 0.0058
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0948
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0008 0.0029
Loa Loa (eye worm) MBCTL1 0.0055 0.0062 0.0587
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0084 0.0122 0.0121
Brugia malayi Bromodomain containing protein 0.0045 0.0041 0.0382
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0231 0.1391
Trichomonas vaginalis hypothetical protein 0.0041 0.0034 0.0309
Loa Loa (eye worm) hypothetical protein 0.0084 0.0122 0.1181
Schistosoma mansoni hypothetical protein 0.0296 0.0555 0.3348
Entamoeba histolytica hypothetical protein 0.011 0.0176 0.4917
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0221 0.0403 0.3309
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0221 0.0403 0.14
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.006 0.1447
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0098 0.015 0.0503
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0008 0.0029
Echinococcus multilocularis expressed conserved protein 0.0186 0.033 0.0329
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.006 0.036
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0062 0.0368
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0008 0.0053
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.0098 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.0102 0.0985
Brugia malayi CHE-14 protein 0.0085 0.0124 0.1197
Loa Loa (eye worm) hypothetical protein 0.0052 0.0057 0.0541
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.0148 0.4149
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0431 0.043
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0711 0.7003
Loa Loa (eye worm) hypothetical protein 0.0055 0.0062 0.0587
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0148 0.0497
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0148 0.1444
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0097 0.0148 0.0497
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0231 0.2259
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0062 0.0587
Schistosoma mansoni patched 1 0.0085 0.0124 0.0742
Schistosoma mansoni troponin I 0.0129 0.0214 0.1288
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0128 0.1034
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0206
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0128 0.1034
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0062 0.0061
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.0098 0.2393
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0186
Mycobacterium ulcerans hypothetical protein 0.0325 0.0616 0.2152
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0176 0.1056
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.0649 0.6383
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.052 0.1015 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0231 0.1391
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0008 0.0166
Brugia malayi acetyltransferase, GNAT family protein 0.0178 0.0313 0.3073
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0148 0.1206
Schistosoma mansoni hypothetical protein 0.0082 0.0117 0.0704
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.0361 0.2175
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1015 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0617 0.1215 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.0345 0.2078
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0221 0.0403 0.14
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.0148 0.0497
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0008 0.0029
Brugia malayi hypothetical protein 0.0084 0.0122 0.1181
Onchocerca volvulus Troponin I homolog 0.0129 0.0214 0.3214
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0062 0.0061
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0021 0.0155
Brugia malayi Importin beta-1 subunit 0.0035 0.0021 0.0186
Loa Loa (eye worm) IMP dehydrogenase 1 0.0221 0.0403 0.3961
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.0548 0.4505
Onchocerca volvulus 0.0032 0.0016 0.0126
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0221 0.0403 0.5
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0097 0.0148 0.0524
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0098 0.015 0.1461
Leishmania major inosine-5-monophosphate dehydrogenase 0.0221 0.0403 0.3309
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.006 0.0573
Brugia malayi TAR-binding protein 0.0255 0.0473 0.4647
Brugia malayi PHD-finger family protein 0.003 0.0012 0.0098
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0008 0.0029
Loa Loa (eye worm) hypothetical protein 0.0048 0.0048 0.0453
Schistosoma mansoni hypothetical protein 0.0129 0.0214 0.1288
Trypanosoma cruzi GMP reductase 0.0221 0.0403 0.3309
Toxoplasma gondii IMP dehydrogenas 0.0221 0.0403 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0008 0.0058
Schistosoma mansoni troponin I 0.0129 0.0214 0.1288
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0046 0.1101
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0617 0.1215 1
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.0649 0.6383
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0008 0.0044
Loa Loa (eye worm) RNA binding protein 0.0255 0.0473 0.4647
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0046 1
Onchocerca volvulus Huntingtin homolog 0.0124 0.0205 0.3071
Echinococcus granulosus snurportin 1 0.0372 0.0711 0.429
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0221 0.0403 0.2431
Loa Loa (eye worm) hypothetical protein 0.0129 0.0214 0.2091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.009 0.0318
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0008 0.0029
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0221 0.0403 0.14
Echinococcus granulosus oncosphere protein Tso22e 0.016 0.0278 0.1671
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.0649 0.6383
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0124 0.0205 0.2
Echinococcus multilocularis troponin i 0.0129 0.0214 0.0213
Brugia malayi mbt repeat family protein 0.0048 0.0048 0.0453
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0085 0.0124 0.1197
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.006 0.1447
Onchocerca volvulus 0.0097 0.0148 0.2192
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0048 0.0286
Loa Loa (eye worm) oxidoreductase 0.0028 0.0008 0.0058
Schistosoma mansoni hypothetical protein 0.0082 0.0117 0.0704
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0231 0.2259
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.0148 0.0497
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0221 0.0403 0.3309
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0008 0.0058
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0057 0.0541
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0087 0.0128 0.1034
Echinococcus granulosus importin subunit beta 1 0.0035 0.0021 0.0123
Loa Loa (eye worm) hypothetical protein 0.0097 0.0148 0.1444
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0124 0.1197
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0057 0.0067 0.1831
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0062 0.0368
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0021 0.0155
Loa Loa (eye worm) troponin 0.0076 0.0106 0.1029
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0008 0.0058
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.006 0.1447
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1015 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0008 0.0029
Entamoeba histolytica hypothetical protein 0.011 0.0176 0.4917
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.0649 0.6383
Entamoeba histolytica acyl-coA synthetase, putative 0.0097 0.0148 0.4149
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0148 0.1444
Schistosoma mansoni tsg101-related 0.0057 0.0067 0.0399
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0124 0.1197
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0008 0.0146
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.0148 0.4149
Brugia malayi Troponin I 0.0129 0.0214 0.2091
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0048 0.0286
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0048 0.0286
Mycobacterium ulcerans transcriptional regulator 0.1407 0.2832 1
Trypanosoma brucei GMP reductase 0.0221 0.0403 0.3309
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0008 0.0053
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0084 0.0122 0.0731
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0178 0.0313 0.1888
Leishmania major importin beta-1 subunit, putative 0.0028 0.0008 0.0044
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0148 0.1206
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0008 0.0058
Schistosoma mansoni troponin I 0.0129 0.0214 0.1288
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0148 0.1444
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0148 0.0497
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0148 0.1206
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0023 0.0206
Schistosoma mansoni hypothetical protein 0.0348 0.0662 0.3993
Mycobacterium ulcerans hypothetical protein 0.0097 0.0148 0.0497
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0002 0.0002
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0008 0.0029
Loa Loa (eye worm) hypothetical protein 0.0104 0.0163 0.1584
Schistosoma mansoni tar DNA-binding protein 0.0255 0.0473 0.2851
Brugia malayi hypothetical protein 0.0235 0.0431 0.4235
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0178 0.0313 0.0313
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.0649 0.6383
Schistosoma mansoni ran 0.0026 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0058
Echinococcus granulosus troponin i 0.0129 0.0214 0.1288
Schistosoma mansoni tar DNA-binding protein 0.0255 0.0473 0.2851
Loa Loa (eye worm) GMP reductase 0.0098 0.015 0.1461
Trypanosoma cruzi kinetoplast DNA-associated protein, putative 0.0043 0.0037 0.0287
Entamoeba histolytica hypothetical protein 0.011 0.0176 0.4917
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0008 0.0053
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0008 0.0058
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0617 0.1215 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0124 0.0203 0.0717
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0008 0.0146
Schistosoma mansoni tsg101-related 0.007 0.0093 0.0557
Schistosoma mansoni importin beta-1 0.0035 0.0021 0.0123
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1657 0.1657
Schistosoma mansoni tsg101-related 0.007 0.0093 0.0557
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1407 0.2832 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0008 0.0058
Onchocerca volvulus 0.0048 0.0048 0.0622
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0002 0.001
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0087 0.0128 0.1034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0097 0.0148 0.0524
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0008 0.0048
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0008 0.0007
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0008 0.0029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0325 0.0616 0.2175
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0008 0.0058
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0008 0.0048
Schistosoma mansoni ran 0.0026 0.0002 0.001
Schistosoma mansoni tar DNA-binding protein 0.0255 0.0473 0.2851
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0057 0.0541
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0021 0.047
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0298 0.1797
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.052 0.1015 1
Brugia malayi hypothetical protein 0.0076 0.0106 0.1029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0231 0.1391
Echinococcus multilocularis snurportin 1 0.0372 0.0711 0.0711
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0231 0.1391
Loa Loa (eye worm) hypothetical protein 0.0043 0.0037 0.0343
Leishmania major guanosine monophosphate reductase 0.0221 0.0403 0.3309
Trichomonas vaginalis glucosylceramidase, putative 0.0359 0.0686 0.6755
Loa Loa (eye worm) hypothetical protein 0.0097 0.0148 0.1444
Brugia malayi hypothetical protein 0.011 0.0176 0.1711
Brugia malayi Troponin T 0.0076 0.0106 0.1029
Echinococcus multilocularis geminin 0.0348 0.0662 0.0661
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.006 0.0573
Loa Loa (eye worm) hypothetical protein 0.0047 0.0046 0.0434
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0221 0.0403 0.1424
Loa Loa (eye worm) spectraplakin 0.0043 0.0037 0.0343
Trichomonas vaginalis glucosylceramidase, putative 0.0359 0.0686 0.6755
Loa Loa (eye worm) hypothetical protein 0.004 0.0032 0.0297
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0221 0.0403 1
Schistosoma mansoni hypothetical protein 0.011 0.0176 0.1056
Brugia malayi GMP reductase 0.0098 0.015 0.1461
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0221 0.0403 0.3309
Loa Loa (eye worm) troponin T 0.0076 0.0106 0.1029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0057 0.0541
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0097 0.0148 0.0497
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.1015 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0048 0.0286
Trypanosoma cruzi GMP reductase 0.0221 0.0403 0.3309
Entamoeba histolytica hypothetical protein 0.0028 0.0008 0.0152
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0948
Brugia malayi Bromodomain containing protein 0.0083 0.012 0.1163
Toxoplasma gondii hypothetical protein 0.01 0.0154 0.3777
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.009 0.0318
Brugia malayi mbt repeat family protein 0.0048 0.0048 0.0453
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.0355 0.348
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0098 0.015 0.1461
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0097 0.0148 0.0497
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0076 0.0106 0.1536
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.0167 0.1355
Schistosoma mansoni hypothetical protein 0.0348 0.0662 0.3993
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0048 0.0625
Echinococcus multilocularis Niemann Pick C1 protein 0.0282 0.0528 0.0528
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0008 0.0029
Echinococcus granulosus tar DNA binding protein 0.0255 0.0473 0.2851
Echinococcus multilocularis tar DNA binding protein 0.0255 0.0473 0.0472
Onchocerca volvulus Putative GMP reductase 0.0098 0.015 0.2218
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0048 0.0453

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 100 uM PubChem BioAssay. Fluorescence polarization aasay to screen for inhibitors that compete for the binding of FadD28 to a bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (binding) = 5.151 uM PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493008, AID493018, AID504382, AID504383] ChEMBL. No reference
IC50 (binding) = 13.894 uM PUBCHEM_BIOASSAY: HTS fluorescence polarization-based dose response confirmatory screen for the Siah-1 primary assay utilizing an alternative fluorophore, fluorescein-labeled plectin. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1817, AID1826] ChEMBL. No reference
IC50 (binding) > 20 uM PUBCHEM_BIOASSAY: Counter Screen using XIAP-Bir3 for Chemical Antagonists of Bir1/2 domains of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1514, AID1638, AID1749, AID1750, AID488957, AID488963] ChEMBL. No reference
IC50 (binding) > 200 uM PUBCHEM_BIOASSAY: uHTS identification of small molecule antagonists of the binding of Siah-1 and a peptide ligand via a fluorescence polarization assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1826, AID2127, AID2141] ChEMBL. No reference
IC50 (binding) > 200 uM PUBCHEM_BIOASSAY: HTS TR-FRET-based dose response confirmatory assay for Siah-1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1817, AID1826] ChEMBL. No reference
Potency (functional) 0.1031 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation in TR assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5012 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (binding) = 5.0119 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.1905 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1258.9254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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