Detailed information for compound 142462

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 661.74 | Formula: C32H45F2N7O6
  • H donors: 4 H acceptors: 8 LogP: 3.12 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: FC(C[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C(C)C)NC(=O)c1nccnc1)F
  • InChi: 1S/C32H45F2N7O6/c1-16(2)23(39-27(43)21-14-35-11-12-36-21)28(44)40-26(32(3,4)5)31(47)41-15-17-7-6-8-19(17)24(41)29(45)38-20(13-22(33)34)25(42)30(46)37-18-9-10-18/h11-12,14,16-20,22-24,26H,6-10,13,15H2,1-5H3,(H,37,46)(H,38,45)(H,39,43)(H,40,44)/t17-,19-,20-,23-,24-,26+/m0/s1
  • InChiKey: YBKIXZLAGGQYMQ-SSARXRJASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Bos taurus Alpha-chymotrypsin Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References
Human rhinovirus sp. Human rhinovirus A protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster CG13744 gene product from transcript CG13744-RA Alpha-chymotrypsin   245 aa 265 aa 34.0 %
Drosophila melanogaster CG31267 gene product from transcript CG31267-RA Alpha-chymotrypsin   245 aa 235 aa 31.5 %
Drosophila melanogaster CG30287 gene product from transcript CG30287-RA Alpha-chymotrypsin   245 aa 247 aa 32.0 %
Echinococcus multilocularis enteropeptidase Alpha-chymotrypsin   245 aa 279 aa 27.2 %
Echinococcus granulosus glycoprotein Antigen 5 Alpha-chymotrypsin   245 aa 297 aa 22.2 %
Schistosoma japonicum ko:K01346 pancreatic elastase II [EC3.4.21.71], putative Alpha-chymotrypsin   245 aa 314 aa 24.5 %
Brugia malayi Trypsin family protein Alpha-chymotrypsin   245 aa 256 aa 21.5 %
Drosophila melanogaster Jonah 65Aiii Alpha-chymotrypsin   245 aa 232 aa 32.8 %
Drosophila melanogaster Jonah 65Aii Alpha-chymotrypsin   245 aa 234 aa 31.2 %
Onchocerca volvulus Alpha-chymotrypsin   245 aa 240 aa 27.5 %
Drosophila melanogaster CG31326 gene product from transcript CG31326-RA Alpha-chymotrypsin   245 aa 270 aa 25.9 %
Drosophila melanogaster CG30323 gene product from transcript CG30323-RB Alpha-chymotrypsin   245 aa 218 aa 21.6 %
Schistosoma japonicum Cercarial protease precursor (EC 3.4.21.-) (Cercarial elastase), putative Alpha-chymotrypsin   245 aa 220 aa 20.9 %
Drosophila melanogaster CG33458 gene product from transcript CG33458-RA Alpha-chymotrypsin   245 aa 255 aa 27.1 %
Loa Loa (eye worm) hypothetical protein Alpha-chymotrypsin   245 aa 287 aa 21.6 %
Drosophila melanogaster CG17239 gene product from transcript CG17239-RB Alpha-chymotrypsin   245 aa 225 aa 32.9 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Alpha-chymotrypsin   245 aa 300 aa 25.7 %
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) Alpha-chymotrypsin   245 aa 300 aa 27.7 %
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Alpha-chymotrypsin   245 aa 225 aa 32.4 %
Onchocerca volvulus Alpha-chymotrypsin   245 aa 237 aa 23.6 %
Echinococcus granulosus Mastin Alpha-chymotrypsin   245 aa 302 aa 26.2 %
Schistosoma japonicum Enteropeptidase, putative Alpha-chymotrypsin   245 aa 268 aa 23.9 %
Drosophila melanogaster CG30288 gene product from transcript CG30288-RC Alpha-chymotrypsin   245 aa 236 aa 30.1 %
Drosophila melanogaster CG18420 gene product from transcript CG18420-RA Alpha-chymotrypsin   245 aa 233 aa 26.2 %
Schistosoma mansoni cercarial elastase (S01 family) Alpha-chymotrypsin   245 aa 213 aa 26.8 %
Echinococcus multilocularis glycoprotein Antigen 5 Alpha-chymotrypsin   245 aa 296 aa 23.0 %
Brugia malayi Trypsin family protein Alpha-chymotrypsin   245 aa 245 aa 24.5 %
Loa Loa (eye worm) hypothetical protein Alpha-chymotrypsin   245 aa 252 aa 21.8 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Alpha-chymotrypsin   245 aa 247 aa 31.6 %
Drosophila melanogaster CG11313 gene product from transcript CG11313-RC Alpha-chymotrypsin   245 aa 255 aa 29.0 %
Drosophila melanogaster CG18180 gene product from transcript CG18180-RA Alpha-chymotrypsin   245 aa 232 aa 31.0 %
Drosophila melanogaster CG3505 gene product from transcript CG3505-RA Alpha-chymotrypsin   245 aa 252 aa 28.2 %
Drosophila melanogaster CG34436 gene product from transcript CG34436-RA Alpha-chymotrypsin   245 aa 244 aa 24.6 %
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Alpha-chymotrypsin   245 aa 239 aa 33.5 %
Onchocerca volvulus Alpha-chymotrypsin   245 aa 251 aa 22.3 %
Echinococcus granulosus enteropeptidase Alpha-chymotrypsin   245 aa 279 aa 26.5 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Schistosoma mansoni cercarial elastase (S01 family) Alpha-chymotrypsin   245 aa 237 aa 24.5 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Drosophila melanogaster CG14990 gene product from transcript CG14990-RA Alpha-chymotrypsin   245 aa 245 aa 29.0 %
Echinococcus granulosus transmembrane protease serine 3 Alpha-chymotrypsin   245 aa 270 aa 31.9 %
Drosophila melanogaster CG10405 gene product from transcript CG10405-RB Alpha-chymotrypsin   245 aa 237 aa 31.6 %
Drosophila melanogaster Spatzle-Processing Enzyme Alpha-chymotrypsin   245 aa 275 aa 29.1 %
Drosophila melanogaster CG30083 gene product from transcript CG30083-RB Alpha-chymotrypsin   245 aa 246 aa 29.7 %
Schistosoma mansoni cercarial elastase (S01 family) Alpha-chymotrypsin   245 aa 218 aa 22.9 %
Schistosoma japonicum Transmembrane protease, serine 9, putative Alpha-chymotrypsin   245 aa 231 aa 22.5 %
Drosophila melanogaster Jonah 99Ci Alpha-chymotrypsin   245 aa 234 aa 29.5 %
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family Alpha-chymotrypsin   245 aa 300 aa 27.3 %
Schistosoma mansoni aminopeptidase PILS (M01 family) Alpha-chymotrypsin   245 aa 300 aa 23.3 %
Drosophila melanogaster CG4914 gene product from transcript CG4914-RA Alpha-chymotrypsin   245 aa 238 aa 34.9 %
Drosophila melanogaster CG5909 gene product from transcript CG5909-RA Alpha-chymotrypsin   245 aa 259 aa 29.3 %
Echinococcus multilocularis transmembrane protease serine 3 Alpha-chymotrypsin   245 aa 266 aa 32.7 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Drosophila melanogaster betaTrypsin Alpha-chymotrypsin   245 aa 239 aa 40.6 %
Drosophila melanogaster Trypsin 29F Alpha-chymotrypsin   245 aa 238 aa 38.2 %
Drosophila melanogaster CG32277 gene product from transcript CG32277-RA Alpha-chymotrypsin   245 aa 237 aa 27.0 %
Brugia malayi Trypsin family protein Alpha-chymotrypsin   245 aa 249 aa 25.7 %
Echinococcus multilocularis Mastin Alpha-chymotrypsin   245 aa 302 aa 26.2 %
Drosophila melanogaster CG33465 gene product from transcript CG33465-RC Alpha-chymotrypsin   245 aa 221 aa 19.0 %
Drosophila melanogaster CG31220 gene product from transcript CG31220-RB Alpha-chymotrypsin   245 aa 268 aa 23.9 %
Drosophila melanogaster CG9673 gene product from transcript CG9673-RB Alpha-chymotrypsin   245 aa 243 aa 25.9 %
Drosophila melanogaster CG3916 gene product from transcript CG3916-RA Alpha-chymotrypsin   245 aa 235 aa 35.3 %
Schistosoma mansoni cercarial elastase (S01 family) Alpha-chymotrypsin   245 aa 213 aa 26.8 %
Drosophila melanogaster CG9733 gene product from transcript CG9733-RB Alpha-chymotrypsin   245 aa 261 aa 29.1 %
Drosophila melanogaster CG4815 gene product from transcript CG4815-RA Alpha-chymotrypsin   245 aa 216 aa 24.1 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Alpha-chymotrypsin   245 aa 239 aa 36.8 %
Drosophila melanogaster Jonah 66Ci Alpha-chymotrypsin   245 aa 231 aa 31.6 %
Onchocerca volvulus Alpha-chymotrypsin   245 aa 250 aa 25.2 %
Schistosoma japonicum ko:K09637 transmembrane protease, serine 6, putative Alpha-chymotrypsin   245 aa 240 aa 30.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.1052 0.2428
Brugia malayi PHD-finger family protein 0.0059 0.0743 0.1711
Leishmania major cysteine peptidase A (CPA) 0.0075 0.1052 0.5382
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0366 0.0633
Onchocerca volvulus 0.0075 0.1052 0.1982
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.5495 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.09 0.1156
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.2571 0.6035
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0818 0.1048
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0301 0.1464
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0401 0.2733
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Schistosoma mansoni zinc finger protein 0.0048 0.0537 0.068
Echinococcus multilocularis cysteine protease 0.0075 0.1052 0.1357
Schistosoma mansoni hypothetical protein 0.0334 0.5988 0.7839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Schistosoma mansoni cpg binding protein 0.0098 0.1488 0.1929
Plasmodium falciparum importin beta, putative 0.0029 0.0165 0.1042
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Onchocerca volvulus 0.0075 0.1052 0.1982
Echinococcus granulosus geminin 0.0334 0.5988 0.7839
Echinococcus granulosus GPCR family 2 0.0063 0.0818 0.1048
Echinococcus granulosus cathepsin L cysteine proteinase 0.0075 0.1052 0.1357
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.2399 0.3125
Loa Loa (eye worm) hypothetical protein 0.0078 0.1095 0.1964
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0234 0.408 0.5333
Onchocerca volvulus Cathepsin F homolog 0.0075 0.1052 0.1982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0608 0.1404
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0302 0.0697
Schistosoma mansoni bromodomain containing protein 0.0137 0.2224 0.2895
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0401 0.0925
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0094 0.1415 0.4646
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0301 0.0513
Schistosoma mansoni hypothetical protein 0.0063 0.0818 0.1048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0122 0.1939 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0094 0.1415 0.2549
Plasmodium vivax SET domain protein, putative 0.0033 0.0241 0.1589
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0061 0.014
Trypanosoma cruzi cysteine proteinase, putative 0.0041 0.0401 0.127
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0059 0.0052
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0301 0.2013
Echinococcus multilocularis geminin 0.0334 0.5988 0.7839
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0401 0.1988
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0386 0.2629
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.2571 0.3351
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.1891 0.1638
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0061 0.014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0302 0.0371
Giardia lamblia Cathepsin B precursor 0.0068 0.0905 0.6346
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0165 0.0758
Entamoeba histolytica cysteine proteinase, putative 0.0075 0.1052 0.7399
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.3765 0.6841
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0301 0.0694
Brugia malayi Cathepsin L-like precursor 0.0075 0.1052 0.2443
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.2708 0.3531
Loa Loa (eye worm) hypothetical protein 0.0052 0.0608 0.1075
Trypanosoma cruzi cysteine peptidase, putative 0.0122 0.1939 0.6388
Trypanosoma brucei ISWI complex protein 0.0031 0.0205 0.0964
Leishmania major cathepsin L-like protease 0.0122 0.1939 1
Schistosoma mansoni hypothetical protein 0.0063 0.0818 0.1048
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0096 0.0545
Toxoplasma gondii cathepsin CPL 0.0075 0.1052 0.3438
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.4247 0.7721
Brugia malayi Papain family cysteine protease containing protein 0.0075 0.1052 0.2443
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0401 0.0501
Loa Loa (eye worm) hypothetical protein 0.0136 0.2214 0.4009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0608 0.4217
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0301 0.0694
Loa Loa (eye worm) hypothetical protein 0.0063 0.0818 0.1458
Trypanosoma cruzi cruzipain precursor, putative 0.0122 0.1939 0.6388
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0071
Giardia lamblia Cathepsin B precursor 0.0068 0.0905 0.6346
Trypanosoma cruzi cysteine protease, putative 0.0041 0.0401 0.127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0302 0.0371
Entamoeba histolytica cysteine proteinase, putative 0.0075 0.1052 0.7399
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0548 0.1265
Schistosoma mansoni ap endonuclease 0.0094 0.1415 0.1834
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0241 0.0291
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0818 0.1048
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Onchocerca volvulus Cathepsin L homolog 0.0075 0.1052 0.1982
Trypanosoma cruzi cysteine proteinase, putative 0.0041 0.0401 0.127
Toxoplasma gondii exonuclease III APE 0.0094 0.1415 0.4646
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0301 0.0369
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0818 0.1048
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.2145 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.09 0.1156
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0401 0.0902
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0234 0.408 0.5333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0122 0.1939 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0068 0.0905 0.2089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0122 0.1939 1
Echinococcus granulosus snurportin 1 0.0308 0.5495 0.7192
Brugia malayi Cathepsin L-like precursor 0.0075 0.1052 0.2443
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.2708 0.3531
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0612 0.032
Onchocerca volvulus 0.0075 0.1052 0.1982
Loa Loa (eye worm) hypothetical protein 0.0095 0.1427 0.2571
Brugia malayi Cathepsin L-like precursor 0.0075 0.1052 0.2443
Loa Loa (eye worm) hypothetical protein 0.0143 0.2343 0.4244
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.1891 0.1638
Leishmania major hypothetical protein, conserved 0.0036 0.0302 0.1472
Plasmodium vivax glutathione reductase, putative 0.0052 0.0612 0.4245
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0075 0.1052 0.7399
Echinococcus multilocularis GPCR, family 2 0.0063 0.0818 0.1048
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0169 0.2834 0.2611
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0122 0.1939 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0165 0.0484
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.0581 0.0738
Schistosoma mansoni hypothetical protein 0.0308 0.5495 0.7192
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0059 0.0052
Plasmodium vivax vivapain-1 0.0041 0.0401 0.2733
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0179 0.3024 0.3946
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0179 0.3024 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.1001 0.1289
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0302 0.0697
Brugia malayi CXXC zinc finger family protein 0.0089 0.1317 0.307
Schistosoma mansoni alpha-glucosidase 0.014 0.2277 0.2965
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.4247 0.7721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0612 0.4245
Onchocerca volvulus 0.0075 0.1052 0.1982
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0401 0.0902
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0094 0.1415 0.1148
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0272 0.0332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Loa Loa (eye worm) ctsf protein 0.0075 0.1052 0.1886
Loa Loa (eye worm) hypothetical protein 0.0052 0.0608 0.1075
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0548 0.1759
Echinococcus multilocularis zinc finger protein 0.0048 0.0537 0.068
Schistosoma mansoni hypothetical protein 0.0031 0.0205 0.0243
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0163 0.0188
Loa Loa (eye worm) hypothetical protein 0.0086 0.1256 0.2259
Entamoeba histolytica cysteine protease, putative 0.0075 0.1052 0.7399
Plasmodium falciparum thioredoxin reductase 0.0052 0.0612 0.4245
Echinococcus granulosus cathepsin l1 0.0075 0.1052 0.1357
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0301 0.0935
Schistosoma mansoni hypothetical protein 0.0421 0.7633 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0516
Brugia malayi Pre-SET motif family protein 0.0033 0.0241 0.0525
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0401 0.0501
Mycobacterium ulcerans short chain dehydrogenase 0.0545 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0122 0.1939 1
Trypanosoma cruzi cysteine peptidase, putative 0.0122 0.1939 0.6388
Trypanosoma brucei cysteine peptidase C (CPC) 0.0068 0.0905 0.4616
Onchocerca volvulus 0.0075 0.1052 0.1982
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0075 0.1052 0.7399
Loa Loa (eye worm) hypothetical protein 0.0025 0.0096 0.0139
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0818 0.1888
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0302 0.094
Brugia malayi Cathepsin L-like precursor 0.0075 0.1052 0.2443
Brugia malayi Pre-SET motif family protein 0.0218 0.3765 0.8861
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0041 0.0401 0.0501
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.09 0.1156
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0272 0.0332
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0059 0.0052
Loa Loa (eye worm) acetyltransferase 0.0155 0.2571 0.4659
Leishmania major cathepsin L-like protease 0.0122 0.1939 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0234 0.408 0.5333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Echinococcus granulosus cathepsin l cysteine peptidase 0.0075 0.1052 0.1357
Schistosoma mansoni cathepsin F (C01 family) 0.0075 0.1052 0.1357
Schistosoma mansoni cpg binding protein 0.0089 0.1317 0.1705
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0096 0.0545
Brugia malayi Cathepsin L-like precursor 0.0075 0.1052 0.2443
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.1891 0.8621
Plasmodium vivax vivapain-2 0.0075 0.1052 0.7399
Toxoplasma gondii thioredoxin reductase 0.0052 0.0612 0.1972
Echinococcus granulosus cathepsin b 0.0179 0.3024 0.3946
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.2708 0.6359
Echinococcus granulosus cathepsin b 0.0179 0.3024 0.3946
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0099 0.1495 0.491
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.013 0.2085 0.2714
Loa Loa (eye worm) hypothetical protein 0.0179 0.3024 0.5487
Schistosoma mansoni cpg binding protein 0.0098 0.1488 0.1929
Trypanosoma cruzi cysteine peptidase, putative 0.0122 0.1939 0.6388
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.1001 0.1289
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.2214 0.5192
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0548 0.0694
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0301 0.0694
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0068 0.0905 0.4616
Brugia malayi hypothetical protein 0.0025 0.0096 0.018
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0094 0.1415 0.7274
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0094 0.1415 0.5
Plasmodium vivax vivapain-3 0.0041 0.0401 0.2733
Leishmania major hypothetical protein, conserved 0.0031 0.0205 0.0964
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0122 0.1939 1
Schistosoma mansoni hypothetical protein 0.0063 0.0818 0.1048
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0818 0.1888
Echinococcus multilocularis cpg binding protein 0.0098 0.1488 0.1929
Schistosoma mansoni alpha glucosidase 0.0036 0.0301 0.0369
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.2145 0.19
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0612 0.0778
Brugia malayi beta-lactamase family protein 0.0036 0.0302 0.0668
Leishmania major cathepsin L-like protease 0.0075 0.1052 0.5382
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.3418 0.8039
Echinococcus granulosus cathepsin L 0.0041 0.0401 0.0501
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0548 0.3786
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0301 0.2013
Brugia malayi cathepsin L-like precursor 0.0052 0.0608 0.1393
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0068 0.0905 0.1164
Brugia malayi Bromodomain containing protein 0.0081 0.1162 0.2703
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0094 0.1415 1
Trypanosoma cruzi cysteine peptidase, putative 0.0041 0.0401 0.127
Toxoplasma gondii cathepsin B 0.0068 0.0905 0.2948
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0096 0.0253
Leishmania major cathepsin L-like protease 0.0075 0.1052 0.5382
Brugia malayi exodeoxyribonuclease III family protein 0.0094 0.1415 0.3302
Toxoplasma gondii histone lysine methyltransferase SET1 0.0179 0.3024 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0301 0.0694
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Brugia malayi Cathepsin L-like cysteine proteinase 0.0052 0.0608 0.1393
Schistosoma mansoni zinc finger protein 0.0031 0.0205 0.0243
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0061 0.014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0094 0.1415 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.2145 0.19
Trichomonas vaginalis set domain proteins, putative 0.0248 0.4334 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.3418 0.6207
Brugia malayi Bromodomain containing protein 0.0161 0.2676 0.6284
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0075 0.1052 0.1357
Leishmania major cathepsin L-like protease 0.0075 0.1052 0.5382
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0302 0.1472
Mycobacterium tuberculosis Probable reductase 0.0119 0.1891 0.1638
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0301 0.0694
Loa Loa (eye worm) glutathione reductase 0.0052 0.0612 0.1082
Loa Loa (eye worm) hypothetical protein 0.0067 0.09 0.1607
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.09 0.1156
Echinococcus granulosus cpg binding protein 0.0098 0.1488 0.1929
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0301 0.0935
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0516
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0071
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0183 0.0214
Leishmania major cathepsin L-like protease 0.0075 0.1052 0.5382
Onchocerca volvulus 0.0036 0.0302 0.0148
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0096 0.0545
Brugia malayi beta-lactamase 0.0036 0.0302 0.0668
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0302 0.2023
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.7633 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0302 0.0516
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0058 0.0129
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0191 0.3249 0.4241
Onchocerca volvulus 0.0052 0.0608 0.0896
Echinococcus multilocularis cathepsin L 0.0041 0.0401 0.0501
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0302 0.0697
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0612 0.0778
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0075 0.1052 0.1886
Brugia malayi Importin beta-1 subunit 0.0029 0.0165 0.0344
Entamoeba histolytica cysteine proteinase 2 0.0041 0.0401 0.2733
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0612 0.1082
Brugia malayi Cathepsin L-like precursor 0.0052 0.0608 0.1393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0548 0.1759
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Mycobacterium ulcerans epoxide hydrolase EphA 0.0169 0.2834 0.2611
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0548 0.1265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0041 0.0401 0.1988
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0165 0.0758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0608 0.1404
Brugia malayi cathepsin B-like cysteine proteinase 0.0179 0.3024 0.7107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.1052 0.2428
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0386 0.2629
Plasmodium vivax unspecified product 0.0041 0.0401 0.2733
Trichomonas vaginalis esterase, putative 0.0036 0.0302 0.0697
Trichomonas vaginalis ap endonuclease, putative 0.0094 0.1415 0.3266
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0096 0.0253
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.013 0.2085 0.2714
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0163 0.0262
Trichomonas vaginalis ap endonuclease, putative 0.0094 0.1415 0.3266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Trypanosoma cruzi major cysteine proteinase, putative 0.0064 0.0843 0.2742
Brugia malayi RNA, U transporter 1 0.0082 0.1181 0.2747
Treponema pallidum exodeoxyribonuclease (exoA) 0.0094 0.1415 0.5
Leishmania major cathepsin L-like protease 0.0122 0.1939 1
Trypanosoma brucei glucosidase, putative 0.0036 0.0301 0.1464
Onchocerca volvulus 0.0248 0.4334 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0401 0.2733
Onchocerca volvulus 0.0075 0.1052 0.1982
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0272 0.0332
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0096 0.0253
Schistosoma mansoni cathepsin s 0.0023 0.0058 0.0051
Plasmodium vivax vivapain-2 0.0075 0.1052 0.7399
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.1052 0.2428
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0612 0.1972
Plasmodium vivax unspecified product 0.0023 0.0058 0.0277
Brugia malayi Cathepsin L-like precursor 0.0075 0.1052 0.2443
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0516
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0163 0.0188
Echinococcus multilocularis cathepsin L cysteine protease 0.0075 0.1052 0.1357
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0094 0.1415 0.4646
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0401 0.2733
Schistosoma mansoni hypothetical protein 0.0042 0.041 0.0513
Plasmodium falciparum cysteine proteinase falcipain 3 0.0075 0.1052 0.7399
Schistosoma mansoni cathepsin F (C01 family) 0.0075 0.1052 0.1357
Loa Loa (eye worm) hypothetical protein 0.0029 0.0165 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0075 0.1052 0.2428
Schistosoma mansoni hypothetical protein 0.0136 0.2214 0.2883
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0302 0.0697
Onchocerca volvulus 0.0036 0.0302 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0122 0.1939 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0165 0.1042
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0301 0.0694
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.1052 0.2428
Brugia malayi beta-lactamase family protein 0.0036 0.0302 0.0668
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0272 0.0332
Giardia lamblia Cathepsin B precursor 0.0068 0.0905 0.6346
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0059 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.1052 0.2428
Toxoplasma gondii ABC1 family protein 0.0036 0.0302 0.094
Trypanosoma brucei trypanothione reductase 0.0052 0.0612 0.3087
Trypanosoma cruzi ISWI complex protein 0.0031 0.0205 0.0616
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0241 0.0291
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0301 0.0694
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0302 0.0516
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0234 0.408 0.5333
Plasmodium falciparum cysteine proteinase falcipain 1 0.0041 0.0401 0.2733
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0094 0.1415 0.1834
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.2708 0.491
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0179 0.3024 0.3946
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0234 0.408 0.7415
Brugia malayi Thioredoxin reductase 0.0052 0.0612 0.1402
Onchocerca volvulus 0.0089 0.1317 0.2629
Brugia malayi Cathepsin L-like precursor 0.0052 0.0608 0.1393
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0058 0.0071
Schistosoma mansoni importin beta-1 0.0029 0.0165 0.0191
Echinococcus multilocularis snurportin 1 0.0308 0.5495 0.7192
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0302 0.0668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0122 0.1939 1
Echinococcus granulosus cysteine protease 0.0041 0.0401 0.0501
Onchocerca volvulus 0.0094 0.1403 0.2839
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0241 0.0738
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0234 0.408 0.5333
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Loa Loa (eye worm) fibroinase 0.0075 0.1052 0.1886
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0094 0.1415 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0179 0.3024 0.3946
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.0581 0.0738
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.1891 0.1638
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0179 0.3024 0.3946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0234 0.408 0.5333
Schistosoma mansoni hypothetical protein 0.0334 0.5988 0.7839
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Leishmania major hypothetical protein, conserved 0.0025 0.0096 0.0397
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0096 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Loa Loa (eye worm) hypothetical protein 0.0052 0.0608 0.1075
Echinococcus granulosus dnaJ subfamily B 0.0421 0.7633 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0061 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0023 0.0058 0.0092
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0234 0.408 0.9604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.1052 0.2428
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0075 0.1052 0.2428
Echinococcus granulosus zinc finger protein 0.0048 0.0537 0.068
Schistosoma mansoni hypothetical protein 0.0063 0.0818 0.1048
Leishmania major importin beta-1 subunit, putative 0.0023 0.0061 0.0215
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0094 0.1415 0.7274
Loa Loa (eye worm) cathepsin B 0.0068 0.0905 0.1618
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0301 0.0694
Brugia malayi MH2 domain containing protein 0.0243 0.4247 1
Echinococcus granulosus cathepsin L cysteine protease 0.0041 0.0401 0.0501
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.1052 0.3438
Echinococcus granulosus cathepsin l1 0.0052 0.0608 0.0773
Echinococcus multilocularis cathepsin b 0.0179 0.3024 0.3946
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0302 0.0697
Leishmania major cathepsin L-like protease 0.0075 0.1052 0.5382
Echinococcus multilocularis cathepsin L cysteine protease 0.0075 0.1052 0.1357
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0058 0.0129
Trichomonas vaginalis ran, putative 0.0021 0.002 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0122 0.1939 1
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0608 0.0773
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0401 0.0925
Brugia malayi Cathepsin L-like precursor 0.0023 0.0058 0.0092
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0094 0.1415 1
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0041 0.0401 0.127
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0094 0.1415 0.1834
Onchocerca volvulus 0.0075 0.1052 0.1982
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0122 0.1939 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1052 0.1886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0075 0.1052 0.2428
Schistosoma mansoni alpha-glucosidase 0.014 0.2277 0.2965
Echinococcus multilocularis cathepsin b 0.0179 0.3024 0.3946
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.0581 0.0738
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.1891 0.1638
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0301 0.0665
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.023 0.0497
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0059 0.0052
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0401 0.2733
Brugia malayi cathepsin F-like cysteine proteinase 0.0023 0.0058 0.0092
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0301 0.0935
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.1891 0.1638
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0075 0.1052 0.1357
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.1317 0.237
Loa Loa (eye worm) cysteine protease 0.0075 0.1052 0.1886
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0818 0.1458
Trypanosoma cruzi ISWI complex protein 0.0031 0.0205 0.0616
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0516
Echinococcus granulosus importin subunit beta 1 0.0029 0.0165 0.0191
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.041 0.0714
Plasmodium falciparum glutathione reductase 0.0052 0.0612 0.4245
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0241 0.0291
Onchocerca volvulus 0.0036 0.0302 0.0148
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.3418 0.8039
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.4009 0.3822
Schistosoma mansoni ap endonuclease 0.0094 0.1415 0.1834
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0302 0.0371
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0386 0.2629
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0075 0.1052 0.1886
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0301 0.0369
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0165 0.0191
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.2571 0.3351
Onchocerca volvulus Cathepsin L homolog 0.0075 0.1052 0.1982
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0818 0.1048
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.2145 0.19
Loa Loa (eye worm) hypothetical protein 0.02 0.3418 0.6207
Brugia malayi glutathione reductase 0.0052 0.0612 0.1402
Entamoeba histolytica hypothetical protein 0.0023 0.0061 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0122 0.1939 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0041 0.0401 0.2733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.1052 0.2428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.1052 0.2428
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0301 0.0694
Echinococcus multilocularis cysteine protease 0.0075 0.1052 0.1357
Leishmania major trypanothione reductase 0.0052 0.0612 0.3087
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0302 0.094
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0302 0.0371
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0234 0.408 0.5333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0075 0.1052 0.2428
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.2708 0.3531
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0094 0.1415 0.1148
Entamoeba histolytica cysteine protease, putative 0.0041 0.0401 0.2733
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0068 0.0905 0.2949

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 1.88 ug hr-1 ml-1 In vivo area under curve of the compound was determined in rat plasma exposure after oral administration 50 mg/kg ChEMBL. 14684338
C (ADMET) = 0.04 ug ml-1 In vivo concentration of the compound was determined in rat plasma exposure at 8 hour after oral administration 50 mg/kg ChEMBL. 14684338
C (ADMET) = 0.67 uM In vivo concentration of the compound was determined in rat liver exposure 8 hour after oral administration 50 mg/kg ChEMBL. 14684338
Caverage (ADMET) = 3.64 uM In vivo concentration of the compound was determined in rat liver exposure 0-8 hour after oral administration 50 mg/kg ChEMBL. 14684338
CC50 (functional) > 100 uM Cytotoxic activity against HCV Protease in liver Huh-7 cells ChEMBL. 14684338
CC50 (functional) > 100 uM Cytotoxic activity against HCV Protease in liver Huh-7 cells ChEMBL. 14684338
IC50 (binding) = 2.9 uM Inhibitory activity of the compound against Protease using replicon assay in rats at 25 microM concentration ChEMBL. 14684338
IC50 (binding) = 2.9 uM Inhibitory activity of the compound against Protease using replicon assay in rats at 25 microM concentration ChEMBL. 14684338
Inhibition (binding) % Inhibitory activity of the compound against thrombin at 100 uM concentration; Not significant ChEMBL. 14684338
Inhibition (binding) % Inhibitory activity of the compound against kallikrein at 100 uM concentration; Not significant ChEMBL. 14684338
Inhibition (binding) % Inhibitory activity of the compound against trypsin at 100 uM concentration; Not significant ChEMBL. 14684338
Inhibition (binding) % Inhibitory activity of the compound against plasmin at 100 uM concentration; Not significant ChEMBL. 14684338
Inhibition (binding) 0 % Inhibitory activity of the compound against kallikrein at 100 uM concentration; Not significant ChEMBL. 14684338
Inhibition (binding) 0 % Inhibitory activity of the compound against thrombin at 100 uM concentration; Not significant ChEMBL. 14684338
Inhibition (binding) 0 % Inhibitory activity of the compound against plasmin at 100 uM concentration; Not significant ChEMBL. 14684338
Inhibition (binding) 0 % Inhibitory activity of the compound against trypsin at 100 uM concentration; Not significant ChEMBL. 14684338
Ki (binding) = 5 nM Inhibitory activity of the compound against cathepsin B ChEMBL. 14684338
Ki (binding) = 5 nM Inhibitory activity of the compound against cathepsin B ChEMBL. 14684338
Ki (functional) = 15 nM Inhibitory activity of the compound against elastase ChEMBL. 14684338
Ki (functional) = 15 nM Inhibitory activity of the compound against elastase ChEMBL. 14684338
Ki (binding) = 30 nM Inhibitory activity of the compound against cathepsin L ChEMBL. 14684338
Ki (binding) = 30 nM Inhibitory activity of the compound against cathepsin L ChEMBL. 14684338
Ki (binding) = 303 nM Inhibitory activity of the compound against Chymotrypsin ChEMBL. 14684338
Ki (binding) = 303 nM Inhibitory activity of the compound against Chymotrypsin ChEMBL. 14684338
Ki (binding) = 1370 nM Inhibitory activity of the compound against cathepsin K ChEMBL. 14684338
Ki (binding) = 1370 nM Inhibitory activity of the compound against cathepsin K ChEMBL. 14684338
Ki (binding) = 0.2 uM Binding affinity of the compound towards Protease using PNA assay in rats ChEMBL. 14684338
Ki (binding) = 0.2 uM Binding affinity of the compound towards Protease using PNA assay in rats ChEMBL. 14684338
Ratio (ADMET) = 1.3 Ratio of the concentration of liver to that of IC50 replication of the compound was determined ChEMBL. 14684338
Ratio (binding) > 34 Ratio of cytotoxicity (CC50) to that of replicon (IC50) of the compound was determined ChEMBL. 14684338

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 14684338

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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