Detailed information for compound 1437799

Basic information

Technical information
  • TDR Targets ID: 1437799
  • Name: N,N-dimethyl-4-[2-(1-phenyltetrazol-5-yl)ethe nyl]aniline
  • MW: 291.35 | Formula: C17H17N5
  • H donors: 0 H acceptors: 3 LogP: 3.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc(cc1)/C=C/c1nnnn1c1ccccc1)C
  • InChi: 1S/C17H17N5/c1-21(2)15-11-8-14(9-12-15)10-13-17-18-19-20-22(17)16-6-4-3-5-7-16/h3-13H,1-2H3/b13-10+
  • InChiKey: DWDLRYXCDMZXJX-JLHYYAGUSA-N  


Substructure search Similarity search

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Synonyms

  • N,N-dimethyl-4-[(E)-2-(1-phenyltetrazol-5-yl)ethenyl]aniline
  • N,N-dimethyl-4-[(E)-2-(1-phenyltetrazol-5-yl)vinyl]aniline
  • N,N-dimethyl-4-[2-(1-phenyltetrazol-5-yl)vinyl]aniline
  • N,N-dimethyl-4-[(E)-2-(1-phenyl-5-tetrazolyl)vinyl]aniline
  • N,N-dimethyl-4-[2-(1-phenyl-5-tetrazolyl)vinyl]aniline
  • dimethyl-[4-[(E)-2-(1-phenyltetrazol-5-yl)vinyl]phenyl]amine
  • dimethyl-[4-[2-(1-phenyltetrazol-5-yl)vinyl]phenyl]amine
  • N,N-dimethyl-4-[(E)-2-(1-phenyl-1,2,3,4-tetrazol-5-yl)ethenyl]aniline
  • N,N-dimethyl-4-[2-(1-phenyl-1,2,3,4-tetrazol-5-yl)ethenyl]aniline
  • MLS000569519
  • CBDivE_008265
  • SMR000173894
  • ZINC03998777
  • BAS 00121581
  • Dimethyl-{4-[2-(1-phenyl-1H-tetrazol-5-yl)-vinyl]-phenyl}-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens growth factor, augmenter of liver regeneration Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Brugia malayi Augmenter of liver regeneration Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Theileria parva hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) hepatopoietin HPO2 Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium berghei FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum FAD-linked sulfhydryl oxidase ALR, putative Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis human hepatopoietin-like protein, putative Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0088 0.0199 0.0199
Brugia malayi Augmenter of liver regeneration 0.0041 0.0023 0.0023
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2706 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.018 0.0542 1
Onchocerca volvulus 0.006 0.0092 0.1694
Loa Loa (eye worm) hepatopoietin HPO2 0.0041 0.0023 0.0045
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0409 0.1399 0.3454
Schistosoma mansoni hypothetical protein 0.0357 0.1206 0.1206
Loa Loa (eye worm) phosphatidylinositol 3 0.1101 0.3991 0.7719
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0357 0.1206 0.1206
Trichomonas vaginalis PIKK family atypical protein kinase 0.1021 0.3692 0.8164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0921 0.3318 0.7323
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.018 0.0542 0.1085
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0256 0.0825 0.0825
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1101 0.3991 0.3991
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0882 0.3171 0.793
Schistosoma mansoni patched 1 0.0051 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0922 0.3319 0.7325
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.014 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0259 0.0839 0.1753
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0409 0.1399 0.301
Loa Loa (eye worm) cytochrome P450 family protein 0.0088 0.0199 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0922 0.3319 0.7325
Trichomonas vaginalis PIKK family atypical protein kinase 0.1101 0.3991 0.8835
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.018 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0644 0.2279 0.4987
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.018 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0644 0.2279 0.4987
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0409 0.1399 0.3454
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.032 0.032
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0937 0.0937
Leishmania major phosphatidylinositol kinase related protein, putative 0.018 0.0542 0.1156
Loa Loa (eye worm) hypothetical protein 0.006 0.0092 0.0178
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0023 0.0282
Entamoeba histolytica hypothetical protein 0.018 0.0542 0.129
Plasmodium vivax hypothetical protein 0.018 0.0542 0.657
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.1101 0.3991 0.8835
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0143 0.5
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0256 0.0825 0.1787
Brugia malayi CHE-14 protein 0.0051 0.0059 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0143 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0409 0.1399 0.301
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0155 0.0299
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1101 0.3991 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0942 0.3395 0.7495
Leishmania major hypothetical protein, conserved 0.0273 0.0892 0.1936
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0937 0.0937
Loa Loa (eye worm) hypothetical protein 0.0357 0.1206 0.2333
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0256 0.0825 0.0825
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2706 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0256 0.0825 0.172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0717 0.2552 0.5601
Loa Loa (eye worm) phosphatidylinositol kinase 0.018 0.0542 0.1048
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.3617 0.7994
Trichomonas vaginalis conserved hypothetical protein 0.0357 0.1206 0.2578
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0644 0.2279 0.2279
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0542 0.1085
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0908 0.3269 0.7213
Schistosoma mansoni survival motor neuron protein 0.0058 0.0086 0.0086
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.018 0.0542 0.0542
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0256 0.0825 0.0825
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0086 0.0086
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0908 0.3269 0.3253
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0256 0.0825 0.1595
Leishmania major hypothetical protein, unknown function 0.018 0.0542 0.1156
Loa Loa (eye worm) phosphatidylinositol 3 0.0229 0.0725 0.1402
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0155 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.1021 0.3692 0.8164
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.0023 0.0282
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.157 0.5744 0.5744
Schistosoma mansoni hypothetical protein 0.0058 0.0086 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0155 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0921 0.3318 0.7323
Loa Loa (eye worm) hypothetical protein 0.0398 0.1357 0.2625
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0143 0.0266
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2706 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0842 0.302 0.6654
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0485 0.1682 0.1682
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0409 0.1399 0.1399
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0313 0.0313
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0143 0.0143
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0041 0.0023 0.0023
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.0825 0.0803
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0256 0.0825 0.2005
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0155 0.0155
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0119 0.0313 0.0606
Echinococcus multilocularis protein patched 0.0051 0.0059 0.0059
Echinococcus multilocularis tumor protein p63 0.0408 0.1396 0.1396
Echinococcus granulosus tar DNA binding protein 0.0076 0.0155 0.0155
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0409 0.1399 0.3066
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.018 0.0542 0.1156
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0673 0.2389 0.5235
Brugia malayi hypothetical protein 0.0286 0.0937 0.0937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0485 0.1682 0.3647
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1101 0.3991 0.3991
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0617 0.2179 0.4805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0644 0.2279 0.4987
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0908 0.3269 0.8177
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.018 0.0542 0.1156
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0023 0.0064
Toxoplasma gondii target of rapamycin (TOR), putative 0.1001 0.3617 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.018 0.0542 0.1498
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1101 0.3991 0.8844
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0542 0.1085
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.3617 0.7994
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.018 0.0542 0.052
Entamoeba histolytica hypothetical protein 0.0755 0.2695 0.6727
Loa Loa (eye worm) phosphatidylinositol 3 0.018 0.0542 0.1048
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0485 0.1682 0.1663
Loa Loa (eye worm) phosphatidylinositol 3 0.018 0.0542 0.1048
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.018 0.0542 0.657
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0537 0.188 0.5198
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0842 0.302 0.6654
Trichomonas vaginalis PIKK family atypical protein kinase 0.124 0.4509 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0313 0.0713
Plasmodium vivax hypothetical protein, conserved 0.018 0.0542 0.657
Leishmania major phosphatidylinositol 4-kinase, putative 0.018 0.0542 0.1156
Echinococcus multilocularis 0.018 0.0542 0.0542
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1022 0.3693 0.8181
Trichomonas vaginalis PIKK family atypical protein kinase 0.1021 0.3692 0.8164
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.052 0.1815 0.4547
Trypanosoma cruzi target of rapamycin kinase 3 0.1022 0.3693 0.3679
Loa Loa (eye worm) phosphatidylinositol 3 0.018 0.0542 0.1048
Entamoeba histolytica hypothetical protein 0.018 0.0542 0.129
Loa Loa (eye worm) hypothetical protein 0.0062 0.0102 0.0198
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1022 0.3693 0.8181
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1101 0.3991 0.8844
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0256 0.0825 0.1787
Loa Loa (eye worm) hypothetical protein 0.0264 0.0858 0.166
Leishmania major phosphatidylinositol 3-kinase, putative 0.0256 0.0825 0.1787
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0028 0.0054
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.018 0.0542 0.657
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.018 0.0542 0.129
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0211 0.0211
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0443 0.1528 0.1528
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0155 0.0299
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0485 0.1682 0.3698
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0143 0.0143
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.018 0.0542 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0842 0.302 0.6654
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.124 0.4509 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.03 0.03
Leishmania major phosphatidylinositol 3-kinase, putative 0.0842 0.302 0.6681
Loa Loa (eye worm) hypothetical protein 0.006 0.0094 0.0182
Leishmania major phosphatidylinositol kinase, putative 0.018 0.0542 0.1156
Echinococcus granulosus tumor protein p63 0.0408 0.1396 0.1396
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.0825 0.228
Loa Loa (eye worm) hypothetical protein 0.0079 0.0166 0.0321
Loa Loa (eye worm) RNA binding protein 0.0076 0.0155 0.0299
Echinococcus multilocularis protein dispatched 1 0.0058 0.0086 0.0086
Brugia malayi TAR-binding protein 0.0076 0.0155 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0664 0.2354 0.5157
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0908 0.3269 0.7213
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.03 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0922 0.3319 0.7325
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0644 0.2279 0.2279
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.018 0.0542 0.1498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0921 0.3318 0.7323
Echinococcus granulosus expressed conserved protein 0.0112 0.0286 0.0286
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0673 0.2389 0.5235
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2706 1 1
Schistosoma mansoni hypothetical protein 0.0043 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.0485 0.1682 0.417
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0052
Onchocerca volvulus 0.018 0.0542 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0092 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0218 0.0195
Entamoeba histolytica hypothetical protein 0.018 0.0542 0.129
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0357 0.1206 0.1206
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0155 0.0155
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0485 0.1682 0.1682
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.018 0.0542 0.052
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0041 0.0023 0.0023
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1101 0.3991 1
Mycobacterium leprae conserved hypothetical protein 0.018 0.0542 0.5
Brugia malayi RNA binding protein 0.0076 0.0155 0.0155
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1101 0.3991 0.3977
Loa Loa (eye worm) hypothetical protein 0.0485 0.1682 0.3254
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.3617 0.7994
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0644 0.2279 0.2279
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0409 0.1399 0.1399
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0485 0.1682 0.1682
Brugia malayi jmjC domain containing protein 0.0115 0.03 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.3617 0.7994
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.018 0.0542 0.0542
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.018 0.0542 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.3617 0.7994
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0313 0.0313
Brugia malayi FAT domain containing protein 0.0357 0.1206 0.1206
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0485 0.1682 0.1682
Brugia malayi jmjC domain containing protein 0.0043 0.0028 0.0028
Echinococcus granulosus serine protein kinase ATM 0.0485 0.1682 0.1682
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0256 0.0825 0.172
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0491 0.1705 0.4227
Trichomonas vaginalis PIKK family atypical protein kinase 0.1021 0.3692 0.8164
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.018 0.0542 0.1048
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.0825 0.228
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0256 0.0825 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1101 0.3991 0.3991
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0908 0.3269 0.3253
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0305 0.1009 0.0988
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.157 0.5744 0.5744
Loa Loa (eye worm) hypothetical protein 0.0286 0.0937 0.1813
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0229 0.0725 0.0703
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0443 0.1528 0.1528
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0256 0.0825 0.0825
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.3617 0.7994
Giardia lamblia GTOR 0.1101 0.3991 1
Entamoeba histolytica protein kinase rad3, putative 0.0485 0.1682 0.417
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0755 0.2695 0.6727
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1101 0.3991 0.3977
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0256 0.0825 0.2005
Loa Loa (eye worm) hypothetical protein 0.0537 0.188 0.3636
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.018 0.0542 0.0542
Onchocerca volvulus 0.018 0.0542 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.3617 0.7994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0842 0.302 0.6654
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0031 0.0031
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0409 0.1399 0.301
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.018 0.0542 0.657
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0031 0.0031
Echinococcus multilocularis serine protein kinase ATM 0.0485 0.1682 0.1682
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0155 0.0155
Schistosoma mansoni fkbp-rapamycin associated protein 0.0485 0.1682 0.1682
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0842 0.302 0.6681
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0744 0.2653 0.5828
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0333 0.1116 0.2796
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0031 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0143 0.0143
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0908 0.3269 0.3269
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0256 0.0825 0.172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0942 0.3395 0.7495
Loa Loa (eye worm) phosphatidylinositol 3 0.018 0.0542 0.1048
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0256 0.0825 1
Onchocerca volvulus 0.0058 0.0086 0.1592
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0052 0.0052
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2706 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0339 0.1138 0.2485
Loa Loa (eye worm) hypothetical protein 0.0305 0.1009 0.1951
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0155 0.0155
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0908 0.3269 0.7213
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0028 0.0028
Loa Loa (eye worm) phosphatidylinositol 3 0.124 0.4509 0.8722
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0485 0.1682 0.1663
Schistosoma mansoni hypothetical protein 0.018 0.0542 0.0542
Echinococcus multilocularis expressed conserved protein 0.0112 0.0286 0.0286
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0028 0.0028
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.0023 0.0064
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.018 0.0542 0.052
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.018 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0485 0.1682 0.3647
Plasmodium falciparum phosphatidylinositol 4-kinase 0.018 0.0542 0.657
Brugia malayi hypothetical protein 0.0043 0.0031 0.0031
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0256 0.0825 0.0825
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0059 0.0115
Giardia lamblia Hypothetical protein 0.018 0.0542 0.1358
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0661 0.2344 0.2344
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.018 0.0542 0.657
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.018 0.0542 0.0542
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.018 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0882 0.3171 0.6993
Toxoplasma gondii FATC domain-containing protein 0.0485 0.1682 0.4651
Loa Loa (eye worm) hypothetical protein 0.0051 0.0059 0.0115
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0052
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0256 0.0825 0.0825
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.157 0.5744 0.5744
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.018 0.0542 0.1498
Loa Loa (eye worm) phosphatidylinositol 3 0.1416 0.517 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.124 0.4509 1
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0398 0.1357 0.2625
Echinococcus multilocularis Zinc finger, PHD finger 0.0256 0.0825 0.0825
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0409 0.1399 0.1379
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0143 0.0395
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.018 0.0542 0.0542
Giardia lamblia Phosphatidylinositol 4-kinase 0.018 0.0542 0.1358
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1101 0.3991 0.8844
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0143 0.5
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0644 0.2279 0.4408
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.018 0.0542 0.1085
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0504 0.0504
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1101 0.3991 0.8844
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3534 0.3534
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.0825 0.0803
Trichomonas vaginalis PIKK family atypical protein kinase 0.1021 0.3692 0.8164
Trichomonas vaginalis conserved hypothetical protein 0.0537 0.188 0.4091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0922 0.3319 0.7325
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.1009 0.2133
Trichomonas vaginalis PIKK family atypical protein kinase 0.1101 0.3991 0.8835
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.018 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.1009 0.2133
Schistosoma mansoni phosphatidylinositol 4-kinase 0.018 0.0542 0.0542
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0485 0.1682 0.1682
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0728 0.2595 0.6476
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1101 0.3991 0.3991
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0504 0.0504
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0155 0.0155

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 0.894 uM PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] ChEMBL. No reference
EC50 (functional) < 0.1 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 3.2643 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1735 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 8.4921 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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