Detailed information for compound 1438717

Basic information

Technical information
  • TDR Targets ID: 1438717
  • Name: 4-[3-(furan-2-ylmethyl)-4-oxo-1,3-thiazolidin -2-yl]-N-(3-methylbutyl)benzamide
  • MW: 372.481 | Formula: C20H24N2O3S
  • H donors: 1 H acceptors: 2 LogP: 3.36 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CCNC(=O)c1ccc(cc1)C1SCC(=O)N1Cc1ccco1)C
  • InChi: 1S/C20H24N2O3S/c1-14(2)9-10-21-19(24)15-5-7-16(8-6-15)20-22(18(23)13-26-20)12-17-4-3-11-25-17/h3-8,11,14,20H,9-10,12-13H2,1-2H3,(H,21,24)
  • InChiKey: WVQHOERGVOLNPH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[3-(2-furylmethyl)-4-oxo-thiazolidin-2-yl]-N-isopentyl-benzamide
  • 4-[3-(2-furylmethyl)-4-oxo-2-thiazolidinyl]-N-isopentylbenzamide
  • 4-[3-(2-furylmethyl)-4-keto-thiazolidin-2-yl]-N-isoamyl-benzamide
  • STK141032
  • AH-487/42533205
  • 4-[3-(2-furylmethyl)-4-oxo-1,3-thiazolidin-2-yl]-N-isopentylbenzamide
  • MLS000547217
  • SMR000114534

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0046 0.017
Schistosoma mansoni intermediate filament proteins 0.0085 0.0232 0.0536
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0054 0.013 0.0477
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.0003 0.004
Entamoeba histolytica elongation factor-2 kinase, putative 0.0057 0.0139 0.4098
Echinococcus granulosus expressed protein 0.0033 0.0062 0.0062
Schistosoma mansoni regulator of G protein signaling 0.004 0.0083 0.0193
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0164 0.417
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0057 0.0139 0.051
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0124 0.0456
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0006 0.0006
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0006 0.0006
Onchocerca volvulus 0.0122 0.0353 0.1133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0254 0.0789 1
Brugia malayi 6-phosphofructokinase 0.0118 0.034 0.1244
Onchocerca volvulus 0.0016 0.0006 0.0019
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0017 0.0017
Toxoplasma gondii microneme protein MIC4 0.0015 0.0003 0.004
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.034 0.1065
Schistosoma mansoni hypothetical protein 0.0057 0.0139 0.0321
Schistosoma mansoni hypothetical protein 0.0014 0.0000027032 0.0000062346
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0074 0.0074
Brugia malayi 6-phosphofructokinase 0.0118 0.034 0.1244
Brugia malayi PAN domain containing protein 0.0015 0.0003 0.0011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0845 0.2731 1
Loa Loa (eye worm) hypothetical protein 0.0615 0.1976 0.7234
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0109 0.0312 0.1142
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0076 0.0216
Toxoplasma gondii endonuclease IV APN 0.0075 0.0198 0.2512
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0254 0.0789 1
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0283 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0083 0.024
Onchocerca volvulus 0.002 0.0017 0.0055
Echinococcus multilocularis nAChR subunit 0.002 0.0017 0.0017
Echinococcus granulosus lamin dm0 0.0085 0.0232 0.0232
Echinococcus granulosus serotonin transporter 0.0016 0.0006 0.0006
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0054 0.051
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0083 0.0083
Schistosoma mansoni slit 0.0054 0.013 0.0301
Schistosoma mansoni aldehyde dehydrogenase 0.0254 0.0789 0.182
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0139 0.051
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0084 0.0309
Brugia malayi PAN domain containing protein 0.0015 0.0003 0.0011
Echinococcus granulosus leukotriene A 4 hydrolase 0.0231 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0302
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0017 0.0062
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0032 0.0747
Echinococcus multilocularis voltage dependent calcium channel subunit 0.3054 1 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0017 0.0062
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0074 0.0237
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0074 0.027
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0057 0.0155
Brugia malayi phosphofructokinase 0.0118 0.034 0.1244
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0022
Brugia malayi tailless protein 0.0017 0.001 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0134 0.0134
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0077 0.3717
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0164 0.0601
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0076 0.8927
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0051 0.0121 0.0443
Loa Loa (eye worm) hypothetical protein 0.0085 0.0232 0.0851
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0006 0.0022
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0084 0.1523
Echinococcus multilocularis thyroid hormone receptor alpha 0.0292 0.0913 0.0913
Trichomonas vaginalis rotamase, putative 0.0032 0.0059 0.0161
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Brugia malayi laminin-like protein K08C7.3 precursor 0.0054 0.013 0.0477
Brugia malayi Nuclear hormone receptor E75 0.0017 0.001 0.0036
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0084 0.2483
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0139 0.051
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0054 0.1585
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0017 0.0062
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0198 0.2424
Brugia malayi PAN domain containing protein 0.0015 0.0003 0.0011
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0075 0.0075
Toxoplasma gondii microneme protein MIC17A 0.0015 0.0003 0.004
Onchocerca volvulus 0.0057 0.0139 0.0447
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0017 0.0039
Treponema pallidum sodium- and chloride- dependent transporter 0.0016 0.0006 0.001
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0083 0.0306
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.0795 0.0795
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0017 0.0017
Loa Loa (eye worm) ACC-1 protein 0.002 0.0017 0.0062
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0046 0.2061
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0006 0.0014
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0006 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0134 0.0134
Brugia malayi Pre-SET motif family protein 0.0845 0.2731 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0113
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0043 0.0096 0.022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0083 0.0193
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0006 0.0014
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0046 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0134 0.031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0167
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0139 0.051
Toxoplasma gondii microneme protein MIC17C 0.0015 0.0003 0.004
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0031 0.039
Brugia malayi Protein kinase domain containing protein 0.0024 0.0031 0.0113
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0017 0.0105
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0046 0.2061
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0031 0.0906
Brugia malayi nuclear receptor RXR 0.0017 0.001 0.0036
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0046 0.2061
Brugia malayi Sulfatase family protein 0.0017 0.0009 0.0033
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.001 0.001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0076 0.0861
Entamoeba histolytica hypothetical protein 0.004 0.0083 0.2457
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0083 0.0193
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0084 0.0195
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0017 0.0017
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.0086 0.0247
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0006 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0074 0.027
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0062
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0076 0.2028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0101
Mycobacterium ulcerans aldehyde dehydrogenase 0.0254 0.0789 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0083 0.0083
Brugia malayi nuclear receptor NHR-88 0.0037 0.0074 0.027
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.0795 0.0795
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0057 0.2669
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0057 0.2669
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0134 0.0492
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0039
Brugia malayi intermediate filament protein 0.0085 0.0232 0.0851
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0336 0.0336
Brugia malayi Metabotropic glutamate receptor precursor. 0.0089 0.0245 0.0895
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0006 0.0006
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.034 0.0595
Brugia malayi steroid hormone receptor 0.0037 0.0074 0.027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0353 0.0814
Brugia malayi CXXC zinc finger family protein 0.0028 0.0046 0.017
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0006 0.0014
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0017 0.0017
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0006 0.0006
Schistosoma mansoni rab6-interacting 0.002 0.0017 0.0039
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0076 0.06
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0017 0.0038
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0039
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0076 0.0279
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.175 0.5709 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0231 0.0712 0.1642
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0017 0.0017
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0076 0.0861
Brugia malayi nuclear hormone receptor 0.0037 0.0074 0.027
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0059 0.0373
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.034 1
Brugia malayi hypothetical protein 0.002 0.0017 0.0062
Schistosoma mansoni regulator of G protein signaling 0.004 0.0083 0.0193
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0102 0.0375
Schistosoma mansoni cell polarity protein 0.0054 0.013 0.0301
Schistosoma mansoni serine-rich repeat protein 0.0717 0.2313 0.5334
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0057 0.0139 0.3843
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.004 0.0084 0.0309
Echinococcus granulosus RUN 0.002 0.0017 0.0017
Schistosoma mansoni regulator of G protein signaling 0.004 0.0083 0.0193
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0046 0.008
Schistosoma mansoni coup transcription factor 0.0037 0.0074 0.017
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0017 0.0017
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0037 0.0074 0.027
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0006 0.0014
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0006 0.0014
Brugia malayi hypothetical protein 0.0243 0.0753 0.2757
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0102 0.0375
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0037 0.0074 0.027
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0672 0.2162 0.4987
Entamoeba histolytica hypothetical protein 0.0028 0.0046 0.134
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0057 0.0725
Entamoeba histolytica hypothetical protein 0.0043 0.0096 0.2813
Brugia malayi Cache domain containing protein 0.0615 0.1976 0.7234
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0283 0.0283
Echinococcus multilocularis serotonin transporter 0.0016 0.0006 0.0006
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0076 0.0134
Schistosoma mansoni regulator of G protein signaling 0.004 0.0083 0.0193
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.001 0.0036
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0017 0.0017
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0084 0.0195
Echinococcus multilocularis bloom syndrome protein 0.004 0.0086 0.0086
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0101 0.0285 0.0656
Brugia malayi PAN domain containing protein 0.0015 0.0003 0.0011
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0031 0.0031
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0232 0.0851
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0038 0.0088
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0046 0.0878
Onchocerca volvulus 0.0057 0.0139 0.0447
Schistosoma mansoni cpg binding protein 0.003 0.0052 0.0119
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0634 0.2038 0.7463
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Onchocerca volvulus 0.0016 0.0006 0.0019
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.001 0.0036
Brugia malayi PAN domain containing protein 0.0015 0.0003 0.0011
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0046 0.0468
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0074 0.0074
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0003 0.004
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0046 0.0046
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0017 0.0062
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0164 0.0601
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0017 0.0017
Brugia malayi hypothetical protein 0.0256 0.0795 0.2911
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.001 0.001
Onchocerca volvulus 0.0015 0.0003 0.001
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.034 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0083 0.0306
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0083 0.0083
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0017 0.0017
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0074 0.017
Schistosoma mansoni polycystin 1-related 0.002 0.0017 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0057 0.0155
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0061
Brugia malayi follicle stimulating hormone receptor 0.0256 0.0793 0.2904
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0017 0.0039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0096 0.0096
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0076 1
Echinococcus granulosus geminin 0.0168 0.0506 0.0506
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.001 0.0036
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.034 0.1244
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0074 0.027
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0062 0.0226
Loa Loa (eye worm) CUTiclin family member 0.0057 0.0139 0.051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0076 0.0279
Brugia malayi Zona pellucida-like domain containing protein 0.0057 0.0139 0.051
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0083 0.024
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0059 0.1739
Brugia malayi Zona pellucida-like domain containing protein 0.0057 0.0139 0.051
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0006 0.0075
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0003 0.004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0134 0.0492
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0164 0.0164
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0017 0.0105
Brugia malayi ecdysone receptor 0.0017 0.001 0.0036
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0003 0.004
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0017 0.0062
Onchocerca volvulus 0.0961 0.3114 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0057 0.1685
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0074 0.027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0012
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1389 0.4522 0.4522
Schistosoma mansoni lipoxygenase 0.0055 0.0133 0.0306
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.001 0.0031
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.008 0.0217 0.0795
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0083 0.0306
Loa Loa (eye worm) hypothetical protein 0.004 0.0083 0.0306
Echinococcus multilocularis lamin dm0 0.0085 0.0232 0.0232
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0122 0.0353 0.4472
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0017 0.0039
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0017 0.0062
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.001 0.0036
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0074 0.0074
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0054 0.0144
Brugia malayi hypothetical protein 0.0017 0.0009 0.0033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0255 0.0792 0.1827
Loa Loa (eye worm) doublecortin family protein 0.002 0.0017 0.0062
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0074 0.027
Echinococcus multilocularis RUN 0.002 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0012
Echinococcus multilocularis tumor protein p63 0.035 0.1103 0.1103
Loa Loa (eye worm) glutamate receptor 0.0089 0.0245 0.0895
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0083 0.0083
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.034 0.0784
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0074 0.0237
Schistosoma mansoni thyroid hormone receptor 0.0292 0.0913 0.2106
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0017 0.0039
Loa Loa (eye worm) LGC-31 protein 0.002 0.0017 0.0062
Echinococcus granulosus cpg binding protein 0.003 0.0052 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0353 0.0814
Echinococcus granulosus bloom syndrome protein 0.004 0.0086 0.0086
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0076 0.366
Entamoeba histolytica hypothetical protein 0.004 0.0083 0.2457
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0304 0.0702
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0083 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0074 0.027
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0046 0.4844
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0003 0.0012
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0017 0.0063
Loa Loa (eye worm) RecQ helicase 0.004 0.0086 0.0314
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0061
Schistosoma mansoni DNA helicase recq1 0.0028 0.0046 0.0105
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0059 0.0749
Brugia malayi hypothetical protein 0.0043 0.0096 0.035
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1332 0.4336 1
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.034 0.1065
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0074 0.017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0074 0.027
Schistosoma mansoni rab6-interacting 0.002 0.0017 0.0039
Schistosoma mansoni ap endonuclease 0.0038 0.0076 0.0176
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0003 0.004
Loa Loa (eye worm) hypothetical protein 0.0054 0.013 0.0477
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0074 0.027
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Schistosoma mansoni hypothetical protein 0.0717 0.2313 0.5334
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0017 0.0062
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0074 0.0197 0.0197
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0006 0.0014
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0046 0.0577
Brugia malayi nuclear hormone receptor 0.0017 0.001 0.0036
Onchocerca volvulus 0.0024 0.0031 0.0099
Onchocerca volvulus 0.0028 0.0046 0.0149
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0016 0.0006 0.0006
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0003 0.0012
Onchocerca volvulus 0.002 0.0017 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0166 0.0383
Loa Loa (eye worm) hypothetical protein 0.0122 0.0353 0.1292
Brugia malayi PAN domain containing protein 0.0015 0.0003 0.0011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0122 0.0353 0.0353
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0017 0.0017
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0057 0.0139 0.0419
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0147
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0074 0.017
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0057 0.0139 0.0139
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0076 0.0076
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0046 0.0167
Schistosoma mansoni cpg binding protein 0.0028 0.0046 0.0107
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0017 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0074 0.0074
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0076 0.1255
Toxoplasma gondii subtilisin SUB12 0.0015 0.0003 0.004
Schistosoma mansoni DNA helicase recq5 0.0028 0.0046 0.0105
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0084 0.0084
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.0139 0.4098
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.0003 0.004
Echinococcus granulosus tumor protein p63 0.035 0.1103 0.1103
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.034 1
Toxoplasma gondii microneme protein, putative 0.0015 0.0003 0.004
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0084 0.0707
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.034 0.4239
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.034 0.1065
Loa Loa (eye worm) serotonin transporter b 0.0016 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0012
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0084 0.0084
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0083 0.0193
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0086 0.0247
Echinococcus multilocularis expressed protein 0.0774 0.25 0.25
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0074 0.027
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0057 0.0139 0.1764
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0164 0.0164
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.034 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0084 0.0242
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0022
Onchocerca volvulus 0.0051 0.0121 0.0389
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0232 0.0851
Echinococcus granulosus axis inhibition protein axin 0.004 0.0083 0.0083
Brugia malayi Immunoglobulin I-set domain containing protein 0.0057 0.0139 0.051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0076 0.2245
Schistosoma mansoni lamin 0.0085 0.0232 0.0536
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0254 0.0789 1
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Schistosoma mansoni laminin gamma-3 chain 0.0054 0.013 0.0301
Echinococcus multilocularis neurogenic locus notch protein 0.0054 0.013 0.013
Plasmodium vivax thrombospondin-related anonymous protein 0.0057 0.0139 0.3843
Schistosoma mansoni axis inhibition protein axin 0.004 0.0083 0.0193
Entamoeba histolytica hypothetical protein 0.0057 0.0139 0.4098
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.003 0.0381
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0139 0.3843
Schistosoma mansoni metabotropic glutamate receptor 0.0043 0.0095 0.0219
Brugia malayi hypothetical protein 0.002 0.0017 0.0062
Schistosoma mansoni lipoxygenase 0.002 0.0017 0.0039
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0283 0.0653
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0017 0.0009 0.0029
Schistosoma mansoni nuclear hormone receptor 0.0017 0.001 0.0023
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.034 0.4239
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0017 0.0062
Brugia malayi nuclear receptor RXR 0.0019 0.0017 0.0061
Brugia malayi Bloom's syndrome protein homolog 0.004 0.0086 0.0314
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.001 0.0023
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0083 0.0227 0.0832
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0061
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0083 0.0083
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0232 0.0851
Brugia malayi hypothetical protein 0.0026 0.0038 0.0141
Brugia malayi Nuclear hormone receptor E75 0.0017 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0057 0.0155
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0057 0.0155
Brugia malayi laminin alpha chain 0.0054 0.013 0.0477
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0057 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0074 0.0074
Schistosoma mansoni nuclear hormone receptor 0.0017 0.001 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0046 0.0468
Loa Loa (eye worm) CUTiclin-Like family member 0.0057 0.0139 0.051
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0006 0.0075
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0031 0.0113
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.001 0.001
Echinococcus granulosus metabotropic glutamate receptor 5 0.0109 0.0312 0.0312
Echinococcus multilocularis slit 2 protein 0.0054 0.013 0.013
Onchocerca volvulus 0.002 0.0017 0.0055
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0017 0.0017
Schistosoma mansoni regulator of G protein signaling 0.004 0.0083 0.0193
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0139 0.051
Loa Loa (eye worm) abnormal epIthelia family member 0.0054 0.013 0.0477
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0074 0.027
Toxoplasma gondii microneme protein MIC2 0.0057 0.0139 0.1764
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0057 0.0725
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0006 0.0006
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0057 0.0139 0.051
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0302
Echinococcus granulosus dnaJ subfamily B 0.0406 0.1287 0.1287
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0059 0.1739
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.034 0.1065
Brugia malayi Cytochrome P450 family protein 0.007 0.0183 0.0669
Echinococcus granulosus slit 2 protein 0.0054 0.013 0.013
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0017 0.0062
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0074 0.017
Onchocerca volvulus 0.002 0.0017 0.0055
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0074 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0038 0.1133
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0304 0.0702
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0057 0.0139 0.051
Schistosoma mansoni cpg binding protein 0.003 0.0052 0.0119
Brugia malayi von Willebrand Factor 0.0057 0.0139 0.051
Loa Loa (eye worm) hypothetical protein 0.0037 0.0074 0.027
Onchocerca volvulus 0.0016 0.0006 0.0019
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0016 0.0004 0.0009
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0017 0.0062
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0076 0.2245
Schistosoma mansoni ap endonuclease 0.0038 0.0076 0.0176
Loa Loa (eye worm) glutamate receptor 0.0035 0.0067 0.0247
Brugia malayi PAN domain containing protein 0.0015 0.0003 0.0011
Schistosoma mansoni hypothetical protein 0.0406 0.1287 0.2969
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0074 0.027
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0057 0.0139 0.3843
Loa Loa (eye worm) hypothetical protein 0.004 0.0083 0.0306
Onchocerca volvulus 0.0015 0.0003 0.001
Onchocerca volvulus 0.002 0.0017 0.0055
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0039
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0074 0.027
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0017 0.0017
Brugia malayi conserved hypotetical protein 0.0017 0.001 0.0036
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0017 0.0062
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0023 0.0027 0.0101
Onchocerca volvulus 0.0057 0.0139 0.0447
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0017 0.0062
Treponema pallidum 76K protein 0.0057 0.0139 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0134 0.031
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0231 0.0712 0.0712
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0038 0.0939
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0198 0.5611
Onchocerca volvulus 0.0085 0.0232 0.0746
Loa Loa (eye worm) hypothetical protein 0.0037 0.0074 0.027
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0121 0.0279
Echinococcus granulosus nAChR subunit 0.002 0.0017 0.0017
Brugia malayi hypothetical protein 0.0017 0.001 0.0036
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0059 0.0684
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0198 0.5542
Loa Loa (eye worm) hypothetical protein 0.0054 0.013 0.0477
Onchocerca volvulus 0.0057 0.0139 0.0447
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.001 0.0036
Entamoeba histolytica hypothetical protein 0.0043 0.0096 0.2813
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0198 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0046 0.0046
Onchocerca volvulus 0.01 0.0283 0.0908
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0083 0.0306
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0057 0.0139 0.6934
Onchocerca volvulus 0.002 0.0017 0.0054
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0283 0.1036
Loa Loa (eye worm) hypothetical protein 0.004 0.0083 0.0306
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0022
Toxoplasma gondii hypothetical protein 0.0015 0.0003 0.004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0046 0.0577
Mycobacterium ulcerans epimerase 0.002 0.0017 0.0105
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0084 0.0084
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0059 0.1739
Loa Loa (eye worm) hypothetical protein 0.0075 0.0198 0.0726
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0083 0.0306
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0046 0.0167
Loa Loa (eye worm) phosphofructokinase 0.0118 0.034 0.1244
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0038 0.1694
Brugia malayi hypothetical protein 0.004 0.0083 0.0306
Onchocerca volvulus 0.0017 0.001 0.0031
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0254 0.0789 0.0789
Schistosoma mansoni sodium-dependent amino acid transporter 0.0016 0.0006 0.0014
Onchocerca volvulus 0.0015 0.0003 0.001
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0088 0.0088
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0017 0.0576
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0074 0.027
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.034 0.4075
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0017 0.0017
Onchocerca volvulus 0.0015 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0074 0.027
Loa Loa (eye worm) hypothetical protein 0.004 0.0083 0.0306
Loa Loa (eye worm) solute carrier family 6 member 4 0.0016 0.0006 0.0022
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0133 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0083 0.024
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0023 0.0027 0.0101
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0057 0.0155
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0006 0.0022
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0046 0.0167
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0057 0.1479
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.0031 0.0716
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0038 0.1133
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0074 0.027
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0107 0.0304 0.0304
Onchocerca volvulus 0.0015 0.0003 0.001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0122 0.0353 0.0814
Echinococcus granulosus voltage dependent calcium channel subunit 0.1389 0.4522 0.4522
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0139 0.051
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0255 0.0792 0.0792
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0083 0.0083
Loa Loa (eye worm) DR-78 0.0017 0.001 0.0036
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0083 0.0306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0134 0.0134
Toxoplasma gondii aldehyde dehydrogenase 0.0254 0.0789 1
Entamoeba histolytica hypothetical protein 0.004 0.0083 0.2457
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0231 0.0712 0.2607
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0088 0.0088
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0083 0.0306
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0074 0.027
Echinococcus granulosus expressed protein 0.0774 0.25 0.25
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0006 0.0022
Brugia malayi Pre-SET motif family protein 0.0122 0.0353 0.1292
Schistosoma mansoni nuclear receptor 0.0017 0.001 0.0023
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0017 0.0017
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0046 0.0577
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.001 0.0036
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0054 0.0304
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0164 0.483
Echinococcus multilocularis expressed protein 0.0033 0.0062 0.0062
Trichomonas vaginalis rotamase, putative 0.0033 0.0062 0.0169
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0074 0.027
Brugia malayi PXA domain containing protein 0.004 0.0083 0.0306
Loa Loa (eye worm) norepinephrine transporter 0.0016 0.0006 0.0022
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0057 0.1479
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0107 0.0304 0.1115
Onchocerca volvulus 0.0057 0.0139 0.0447
Toxoplasma gondii exonuclease III APE 0.0038 0.0076 0.0967
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0057 0.2669
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0017 0.0017
Onchocerca volvulus 0.002 0.0017 0.0055
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0003 0.0012
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0062
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0057 0.0139 0.6934
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0139 0.051
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.034 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0084 0.0084
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0046 0.1142
Brugia malayi hypothetical protein 0.0016 0.0006 0.0022
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0039
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0039
Brugia malayi hypothetical protein 0.0019 0.0017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0084 0.0084
Leishmania major hypothetical protein, conserved 0.0026 0.0038 0.0102
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0074 0.0074
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.001 0.001
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0109 0.0312 0.0312
Brugia malayi Kringle domain containing protein 0.0024 0.0031 0.0113
Echinococcus granulosus pikachurin 0.0054 0.013 0.013
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0141
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0083 0.0306
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0031 0.0031
Brugia malayi hypothetical protein 0.004 0.0083 0.0306
Trichomonas vaginalis set domain proteins, putative 0.0961 0.3114 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Brugia malayi nuclear receptor NHR-67 0.0017 0.001 0.0036
Brugia malayi hypothetical protein 0.0106 0.0302 0.1105
Mycobacterium ulcerans endonuclease IV 0.0075 0.0198 0.2424
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0083 0.024
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0006 0.0014
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0057 0.0725
Loa Loa (eye worm) hypothetical protein 0.0014 0.0000027032 0.0000098987
Echinococcus multilocularis geminin 0.0168 0.0506 0.0506
Echinococcus granulosus histone lysine methyltransferase setb 0.0122 0.0353 0.0353
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.001 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0076 0.2245
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0017 0.0061
Echinococcus multilocularis musashi 0.0085 0.0232 0.0232
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0017 0.0055
Brugia malayi Cation transporter family protein 0.002 0.0017 0.0062
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0054 0.1585
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0017 0.0062
Onchocerca volvulus 0.0015 0.0003 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0353 0.0814
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0017 0.0061
Schistosoma mansoni hypothetical protein 0.0057 0.0139 0.0321
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0046 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0074 0.027
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0017 0.0038
Chlamydia trachomatis endonuclease IV 0.0075 0.0198 1
Schistosoma mansoni hypothetical protein 0.0052 0.0124 0.0287
Treponema pallidum hypothetical protein 0.0057 0.0139 0.0244
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.001 0.0023
Echinococcus multilocularis cpg binding protein 0.003 0.0052 0.0052
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0012
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.034 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0012
Plasmodium vivax SET domain protein, putative 0.0122 0.0353 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0074 0.027
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0063
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0074 0.0074
Schistosoma mansoni metabotropic glutamate receptor 0.0074 0.0197 0.0455
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0003 0.0012
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0054 0.013 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0083 0.024
Brugia malayi hypothetical protein 0.0017 0.0008 0.0029
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.001 0.001
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.001 0.0023
Schistosoma mansoni thyroid hormone receptor 0.0292 0.0913 0.2106
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0074 0.017
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0017 0.0017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0074 0.017
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0003 0.004
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0038 0.0488
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0183 0.0669
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0083 0.0306
Brugia malayi ecdysteroid receptor 0.0037 0.0074 0.027
Schistosoma mansoni aldehyde dehydrogenase 0.0254 0.0789 0.182
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0122 0.0353 0.0353
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0164 0.483
Entamoeba histolytica hypothetical protein 0.0043 0.0096 0.2813
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0022
Toxoplasma gondii hypothetical protein 0.0016 0.0006 0.0075
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0017 0.0017
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0164 0.483
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0074 0.0074
Onchocerca volvulus 0.0015 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0088 0.0321
Onchocerca volvulus 0.002 0.0017 0.0055
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0083 0.0083
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.034 0.1244
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0017 0.0017
Onchocerca volvulus 0.0057 0.0139 0.0447
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0043 0.0096 0.2813
Schistosoma mansoni axis inhibition protein axin 0.004 0.0083 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0134 0.031
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0084 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0076 0.0216
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0017 0.0017
Schistosoma mansoni loxhd1 0.002 0.0017 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0022
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0046 0.0468
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0074 0.017
Toxoplasma gondii microneme protein MIC17B 0.0015 0.0003 0.004
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0038 0.1694
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0074 0.027
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0083 0.0306
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0198 0.0726
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0083 0.0083
Brugia malayi nuclear receptor NHR-88 0.0017 0.001 0.0036
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0017 0.0319
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.2599 0.2599
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0006 0.0022
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0074 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0074 0.027
Brugia malayi hypothetical protein 0.0017 0.001 0.0036
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0017 0.0062
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0164 0.0379
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0006 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0083 0.024
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0027 0.01
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0017 0.0039
Onchocerca volvulus 0.0057 0.0139 0.0447
Loa Loa (eye worm) hypothetical protein 0.01 0.0283 0.1036
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0017 0.0017
Brugia malayi PAN domain containing protein 0.0015 0.0003 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0046 0.0234
Mycobacterium ulcerans hypothetical protein 0.002 0.0017 0.0105
Onchocerca volvulus 0.0015 0.0003 0.001
Echinococcus granulosus metabotropic glutamate receptor 2 0.0074 0.0197 0.0197
Brugia malayi PAN domain containing protein 0.0015 0.0003 0.0011
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0139 0.051
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0062 0.0226
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Schistosoma mansoni survival motor neuron protein 0.0052 0.0124 0.0287
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0017 0.0017
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.1287 0.1287
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0006 0.0075
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0083 0.0083
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0254 0.0789 0.0789
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0006 0.0022
Schistosoma mansoni hypothetical protein 0.0024 0.0031 0.0071
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0083 0.024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0062
Brugia malayi hypothetical protein 0.0019 0.0017 0.0061
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0083 0.0083
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0096 0.0096
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0057 0.0139 0.3843
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0145 0.1835
Schistosoma mansoni zinc finger protein 0.0017 0.001 0.0023
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0083 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0074 0.0074
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0084 0.0242
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Echinococcus granulosus collagen alpha 1VII chain 0.0057 0.0139 0.0139
Echinococcus multilocularis lamin 0.0085 0.0232 0.0232
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0096 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0074 0.027
Brugia malayi Cation transporter family protein 0.002 0.0017 0.0062
Schistosoma mansoni hypothetical protein 0.002 0.0017 0.0039
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0083 0.0193
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0074 0.0074
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.0793 0.2905
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.0139 0.4098
Onchocerca volvulus 0.0017 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0061
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0057 0.2669
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0084 0.0084
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0017 0.0017
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0017 0.0062
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0074 0.0074
Brugia malayi hypothetical protein 0.0057 0.0139 0.051
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0054 0.013 0.0477
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0037 0.0074 0.027
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.001 0.001
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0107 0.0304 0.0304
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0017 0.0017
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0006 0.0014
Onchocerca volvulus 0.0016 0.0006 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0074 0.0074
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0017 0.0017
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0083 0.0306
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0017 0.0062
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0084 0.0242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0074 0.027
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0074 0.027
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.001 0.0031
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0164 0.1758
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0074 0.017
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.0031 0.1293
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0083 0.0193
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0256 0.0795 0.2911
Toxoplasma gondii hypothetical protein 0.0016 0.0006 0.0075
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0016 0.0006 0.0022
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0003 0.004
Brugia malayi von Willebrand factor type A domain containing protein 0.0057 0.0139 0.051
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0304 0.0702
Loa Loa (eye worm) hypothetical protein 0.0037 0.0074 0.027
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0083 0.0193
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.001 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0074 0.0074
Echinococcus granulosus intermediate filament protein 0.0085 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Brugia malayi Cation transporter family protein 0.002 0.0017 0.0062
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0016 0.0006 0.0006
Echinococcus granulosus lamin 0.0085 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0022
Schistosoma mansoni lamin 0.0085 0.0232 0.0536
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0107 0.0304 0.1115
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0017 0.0039
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0254 0.0789 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Brugia malayi Doublecortin family protein 0.002 0.0017 0.0062
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.034 0.034
Onchocerca volvulus 0.0085 0.0232 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0074 0.027
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0255 0.0792 0.0792
Schistosoma mansoni hypothetical protein 0.0168 0.0506 0.1166
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0057 0.6398
Brugia malayi PXA domain containing protein 0.004 0.0083 0.0306
Loa Loa (eye worm) ACC-1 protein 0.002 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0062
Echinococcus multilocularis pikachurin 0.0054 0.013 0.013
Onchocerca volvulus 0.0015 0.0003 0.001
Schistosoma mansoni hypothetical protein 0.0168 0.0506 0.1166
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0084 0.2483
Schistosoma mansoni rotamase 0.0033 0.0062 0.0142
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0074 0.0237
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0075 0.0075
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.001 0.001
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0083 0.0193
Echinococcus granulosus neurogenic locus notch protein 0.0054 0.013 0.013
Brugia malayi PAN domain containing protein 0.0015 0.0003 0.0011
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0083 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0057 0.0155
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.034 0.0784
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0084 0.2483
Toxoplasma gondii hypothetical protein 0.0015 0.0003 0.004
Onchocerca volvulus Putative nachr subunit 0.002 0.0017 0.0055
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0076 0.0076
Echinococcus granulosus axis inhibition protein axin 0.004 0.0083 0.0083
Onchocerca volvulus 0.0015 0.0003 0.001
Onchocerca volvulus 0.0015 0.0003 0.001
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0046 0.0577
Schistosoma mansoni nuclear receptor 0.0017 0.001 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0062 0.0169
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Plasmodium falciparum thrombospondin-related anonymous protein 0.0057 0.0139 0.6934
Loa Loa (eye worm) hypothetical protein 0.0057 0.0139 0.051
Loa Loa (eye worm) hypothetical protein 0.004 0.0083 0.0306
Brugia malayi EGF-like domain containing protein 0.0054 0.013 0.0477
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0074 0.017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0057 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0074 0.027
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0017 0.0017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0074 0.0074
Loa Loa (eye worm) RGS-3 protein 0.004 0.0083 0.0306
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0074 0.017
Onchocerca volvulus 0.0052 0.0124 0.0399
Onchocerca volvulus 0.0037 0.0074 0.0237
Brugia malayi metabotropic glutamate receptor type 2 0.0043 0.0095 0.0347

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0065 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8024 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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