Detailed information for compound 1492244

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 399.447 | Formula: C19H25N7O3
  • H donors: 2 H acceptors: 5 LogP: 2.96 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CN(N(C(=O)[C@@H](NC(=O)Nc1ccc(cc1)c1noc(n1)C)CC(C)C)C)C
  • InChi: 1S/C19H25N7O3/c1-12(2)10-16(18(27)26(5)25(4)11-20)23-19(28)22-15-8-6-14(7-9-15)17-21-13(3)29-24-17/h6-9,12,16H,10H2,1-5H3,(H2,22,23,28)/t16-/m0/s1
  • InChiKey: ARWSHTCIMVGBCQ-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0023 0.0123 0.0137
Schistosoma mansoni fkbp-rapamycin associated protein 0.002 0.0077 0.0086
Schistosoma mansoni cpg binding protein 0.0029 0.0215 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0159 0.0886
Onchocerca volvulus Cathepsin L homolog 0.0102 0.1394 0.562
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0047 0.0125
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0488 0.1297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0023 0.0123 0.0316
Plasmodium falciparum serine repeat antigen 8 0.0023 0.0123 0.0618
Giardia lamblia Encystation-specific protease 0.0023 0.0123 0.0394
Loa Loa (eye worm) hypothetical protein 0.0022 0.0114 0.0302
Schistosoma mansoni hypothetical protein 0.002 0.0075 0.0084
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0135 0.0096
Echinococcus granulosus cathepsin b 0.0184 0.2706 0.429
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0668 0.1059
Entamoeba histolytica cysteine proteinase 1, putative 0.0055 0.0638 0.3073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0539 0.1432
Trypanosoma cruzi cruzipain precursor, putative 0.0032 0.0271 0.084
Entamoeba histolytica cysteine proteinase, putative 0.007 0.0879 0.4323
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0731 0.0816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0135 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0102 0.1394 0.3698
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0047 0.0115
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0023 0.0123 0.0618
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0724 0.0808
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.002 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0638 0.2846
Trypanosoma cruzi cruzipain precursor, putative 0.0147 0.2124 0.781
Loa Loa (eye worm) hypothetical protein 0.0033 0.0284 0.0755
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0638 0.1696
Plasmodium falciparum serine repeat antigen 9 0.0023 0.0123 0.0618
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0135 0.0359
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0529 0.1405
Loa Loa (eye worm) hypothetical protein 0.0023 0.0123 0.0326
Onchocerca volvulus 0.0102 0.1394 0.562
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Brugia malayi Cathepsin L-like precursor 0.0102 0.1394 0.3705
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0135 0.0424
Brugia malayi mbt repeat family protein 0.0094 0.1259 0.3348
Trypanosoma cruzi cysteine peptidase, putative 0.0102 0.1394 0.5065
Schistosoma mansoni hypothetical protein 0.0047 0.0504 0.0562
Plasmodium falciparum cysteine proteinase falcipain 3 0.0102 0.1394 1
Entamoeba histolytica cysteine protease, putative 0.0023 0.0123 0.0394
Brugia malayi fibroinase precursor 0.0023 0.0123 0.0326
Brugia malayi cathepsin F-like cysteine proteinase 0.0032 0.0271 0.0719
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0036 0.0326 0.0516
Giardia lamblia Cathepsin B precursor 0.0023 0.0123 0.0394
Brugia malayi Bromodomain containing protein 0.0074 0.0945 0.2512
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0159 0.0421
Brugia malayi Cathepsin L-like precursor 0.007 0.0879 0.2335
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0036 0.0326 0.1341
Loa Loa (eye worm) ctsf protein 0.0102 0.1394 0.3705
Plasmodium vivax unspecified product 0.0023 0.0123 0.0618
Leishmania major phosphatidylinositol 3-kinase, putative 0.0036 0.0326 0.1341
Schistosoma mansoni cpg binding protein 0.0032 0.0271 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0023 0.0123 0.0316
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0326 0.0865
Giardia lamblia Cysteine protease 0.0023 0.0123 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Brugia malayi Bromodomain containing protein 0.0037 0.0349 0.0929
Plasmodium vivax serine-repeat antigen (SERA) 0.0023 0.0123 0.0618
Treponema pallidum fructose-bisphosphate aldolase 0.0138 0.197 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0135 0.0424
Schistosoma mansoni hypothetical protein 0.0333 0.5099 0.5692
Schistosoma mansoni cathepsin F (C01 family) 0.0102 0.1394 0.1556
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0102 0.1394 0.3698
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Schistosoma mansoni ap endonuclease 0.0018 0.0047 0.0053
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0023 0.0123 0.0618
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2384 0.6334
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0102 0.1394 0.3698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Schistosoma mansoni survival motor neuron protein 0.0047 0.0504 0.0562
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.3424 0.5428
Onchocerca volvulus Peroxidasin homolog 0.0068 0.085 0.3214
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0359
Schistosoma mansoni hypothetical protein 0.0573 0.8958 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0215 0.0573
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0184 0.2706 1
Entamoeba histolytica cysteine proteinase, putative 0.0102 0.1394 0.7002
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2384 0.6334
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0055 0.0638 0.2223
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0023 0.0123 0.0618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0036 0.0326 0.0516
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0015 0.0004 0.0006
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0047 0.0075
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0135 0.0096
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0326 0.2068
Loa Loa (eye worm) animal heme peroxidase 0.0068 0.085 0.2258
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0204
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0638 0.3073
Leishmania major cathepsin L-like protease 0.0102 0.1394 0.6485
Giardia lamblia Cathepsin B precursor 0.0073 0.0922 0.4548
Giardia lamblia Cathepsin B precursor 0.0023 0.0123 0.0394
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0054 0.0086
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0123 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0055 0.0638 0.0712
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0135 0.0096
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.013 0.0091
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0114 0.0321
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.013 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Echinococcus multilocularis polycomb protein SCMH1 0.0094 0.1259 0.1997
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0638 0.1687
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0488 0.0774
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0023 0.0123 0.0394
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.013 1
Giardia lamblia Cathepsin L precursor 0.0023 0.0123 0.0394
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.2124 0.781
Trypanosoma brucei cysteine peptidase C (CPC) 0.0073 0.0922 0.4212
Plasmodium falciparum serine repeat antigen 5 0.0023 0.0123 0.0618
Onchocerca volvulus Cathepsin L homolog 0.0102 0.1394 0.562
Plasmodium vivax vivapain-2 0.0102 0.1394 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0104
Onchocerca volvulus 0.0024 0.0135 0.0054
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0023 0.0123 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Echinococcus granulosus cathepsin l cysteine peptidase 0.0102 0.1394 0.221
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0123 0.0326
Plasmodium falciparum serine repeat antigen 1 0.0023 0.0123 0.0618
Leishmania major hypothetical protein, conserved 0.0025 0.0159 0.0539
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0135 0.0424
Echinococcus granulosus serine protein kinase ATM 0.0049 0.0539 0.0854
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0023 0.0123 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0114 0.0292
Toxoplasma gondii FATC domain-containing protein 0.0049 0.0539 0.365
Echinococcus multilocularis cathepsin L 0.0023 0.0123 0.0195
Plasmodium falciparum serine repeat antigen 4 0.0023 0.0123 0.0618
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.0429 0.1436
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0023 0.0123 0.0316
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Plasmodium vivax serine-repeat antigen (SERA) 0.0023 0.0123 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0313 0.0496
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.013 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0488 0.0545
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0664 0.4579
Brugia malayi cathepsin Z-like cysteine proteinase 0.0023 0.0123 0.0326
Toxoplasma gondii preprocathepsin c precursor, putative 0.0023 0.0123 0.0562
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.013 0.067
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0094 0.1259 0.5026
Brugia malayi Animal haem peroxidase family protein 0.0068 0.085 0.2258
Giardia lamblia Hypothetical protein 0.0023 0.0123 0.0394
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0326 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0077 0.0194
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0049 0.0539 0.1849
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3762 1
Giardia lamblia Cathepsin L precursor 0.0023 0.0123 0.0394
Echinococcus granulosus cathepsin L 0.0023 0.0123 0.0195
Onchocerca volvulus 0.0102 0.1394 0.562
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0022 0.0114 0.0495
Giardia lamblia Cathepsin B precursor 0.0073 0.0922 0.4548
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0047 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0123 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0879 0.2327
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.002 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0023 0.0123 0.0316
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0373 0.5742 0.9102
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0271 0.0719
Entamoeba histolytica hypothetical protein 0.0023 0.0123 0.0394
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.002 0.0077 0.0122
Onchocerca volvulus Cathepsin F homolog 0.0102 0.1394 0.562
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0488 0.0545
Plasmodium falciparum cysteine proteinase falcipain 1 0.0055 0.0638 0.4422
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0077 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Loa Loa (eye worm) animal heme peroxidase 0.0068 0.085 0.2258
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.1087 0.1724
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0488 0.0774
Onchocerca volvulus 0.0094 0.1259 0.5026
Loa Loa (eye worm) cathepsin B 0.0073 0.0922 0.245
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0077 0.0194
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0102 0.1394 0.3698
Echinococcus granulosus cysteine protease 0.0055 0.0638 0.1012
Loa Loa (eye worm) hypothetical protein 0.0043 0.0443 0.1178
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0047 0.0075
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0102 0.1394 0.221
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0036 0.0326 0.1448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.2124 1
Brugia malayi Cathepsin L-like precursor 0.0102 0.1394 0.3705
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0373 0.5742 0.9102
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Echinococcus multilocularis cysteine protease 0.0102 0.1394 0.221
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0047 0.0008
Echinococcus multilocularis cathepsin b 0.0184 0.2706 0.429
Entamoeba histolytica hypothetical protein 0.0023 0.013 0.0431
Echinococcus granulosus cpg binding protein 0.0032 0.0271 0.043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0104
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.013 0.0615
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0488 0.0774
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0135 0.0359
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.002 0.0077 0.0112
Echinococcus granulosus cathepsin L 0.0055 0.0638 0.1012
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.6308 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.1607 0.4273
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0077 0.0204
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.008
Onchocerca volvulus 0.0047 0.0504 0.1684
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0708 0.1122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Brugia malayi Peroxidasin 0.0068 0.085 0.2258
Brugia malayi cathepsin L precursor 0.0023 0.0123 0.0326
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.197 0.5233
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0077 0.0194
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0036 0.0327 0.1052
Loa Loa (eye worm) blistered cuticle protein 3 0.0068 0.085 0.2258
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0036 0.0326 0.1448
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0135 0.0458
Leishmania major cathepsin L-like protease 0.0147 0.2124 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Brugia malayi mbt repeat family protein 0.0094 0.1259 0.3348
Leishmania major phosphatidylinositol kinase related protein, putative 0.0036 0.0327 0.1347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0102 0.1394 0.3698
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0326 0.1047
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0135 0.0458
Onchocerca volvulus 0.0068 0.085 0.3214
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0055 0.0638 0.0712
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0023 0.0123 0.0137
Onchocerca volvulus 0.0083 0.1087 0.4265
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0708 0.1122
Schistosoma mansoni sex comb on midleg homolog 0.0094 0.1259 0.1406
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.3424 0.5428
Schistosoma mansoni cathepsin B (C01 family) 0.0023 0.0123 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0135 0.0096
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2526 0.671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0123 0.0316
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0638 0.3073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Schistosoma mansoni peroxidasin 0.0068 0.085 0.0948
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0123 0.0316
Plasmodium falciparum serine repeat antigen 2 0.0023 0.0123 0.0618
Trypanosoma cruzi major cysteine proteinase, putative 0.0023 0.0123 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0724 0.1923
Giardia lamblia Cathepsin B precursor 0.0023 0.0123 0.0394
Leishmania major cathepsin L-like protease 0.0102 0.1394 0.6485
Loa Loa (eye worm) hypothetical protein 0.0023 0.0123 0.0326
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0326 0.0865
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0102 0.1394 0.3705
Brugia malayi jmjC domain containing protein 0.0057 0.0668 0.1775
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Loa Loa (eye worm) hypothetical protein 0.0023 0.0123 0.0326
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Leishmania major cathepsin L-like protease 0.0102 0.1394 0.6485
Loa Loa (eye worm) animal heme peroxidase 0.0068 0.085 0.2258
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.003 0.0047
Entamoeba histolytica cysteine protease, putative 0.0023 0.0123 0.0394
Echinococcus multilocularis SAM and MBT domain containing protein 0.0094 0.1259 0.1997
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0159 0.0539
Loa Loa (eye worm) animal heme peroxidase 0.0068 0.085 0.2258
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.002 0.0077 0.0155
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0638 1 1
Giardia lamblia Cathepsin L precursor 0.0023 0.0123 0.0394
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0638 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0387 0.103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0123 0.0316
Plasmodium vivax vivapain-3 0.0055 0.0638 0.4422
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0184 0.2706 0.3021
Brugia malayi cathepsin F-like cysteine proteinase 0.0023 0.0123 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Schistosoma mansoni zinc finger protein 0.0021 0.0085 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Giardia lamblia Cysteine protease 0.0023 0.0123 0.0394
Leishmania major cysteine peptidase A (CPA) 0.0102 0.1394 0.6485
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.013 0.067
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3762 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.002 0.0022
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0138 0.197 1
Echinococcus granulosus cathepsin l1 0.0102 0.1394 0.221
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0138 0.197 1
Brugia malayi Papain family cysteine protease containing protein 0.0102 0.1394 0.3705
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.2384 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0047 0.0024
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0668 0.1059
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2384 0.6334
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0073 0.0922 0.329
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0023 0.0123 0.0394
Giardia lamblia Cathepsin L precursor 0.0023 0.0123 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Echinococcus granulosus peroxidasin 0.0068 0.085 0.1347
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0638 0.3073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0638 0.1696
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0023 0.0123 0.0394
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.197 0.5233
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.013 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0036 0.0326 0.1047
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0023 0.0123 0.0316
Plasmodium falciparum serine repeat antigen 3 0.0023 0.0123 0.0618
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.3762 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0184 0.2706 0.3021
Toxoplasma gondii cathepsin CPL 0.0102 0.1394 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0135 0.0005
Giardia lamblia Cathepsin L precursor 0.0023 0.0123 0.0394
Echinococcus multilocularis zinc finger protein 0.0021 0.0085 0.0135
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0326 0.0865
Loa Loa (eye worm) hypothetical protein 0.0032 0.0271 0.0719
Onchocerca volvulus 0.0068 0.085 0.3214
Brugia malayi Cathepsin L-like precursor 0.0102 0.1394 0.3705
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0102 0.1394 0.3698
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Brugia malayi Blistered cuticle protein 3 0.0068 0.085 0.2258
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0023 0.0123 0.0618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0102 0.1394 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.003 0.0033
Schistosoma mansoni hypothetical protein 0.0408 0.6308 0.7042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0123 0.0316
Loa Loa (eye worm) hypothetical protein 0.0042 0.0429 0.114
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0104
Schistosoma mansoni hypothetical protein 0.0033 0.0284 0.0317
Onchocerca volvulus 0.0102 0.1394 0.562
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0123 0.0316
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0529 0.1405
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0724 0.1147
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0023 0.0123 0.0394
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0036 0.0326 0.1341
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0023 0.0123 0.0137
Echinococcus granulosus cathepsin l1 0.007 0.0879 0.1393
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0039 0.0016
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0131 0.0147
Brugia malayi Cathepsin L-like precursor 0.0032 0.0271 0.0719
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.197 0.5233
Loa Loa (eye worm) hypothetical protein 0.0032 0.0271 0.0719
Loa Loa (eye worm) hypothetical protein 0.007 0.0879 0.2335
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0036 0.0326 0.0363
Trypanosoma cruzi cysteine proteinase, putative 0.0055 0.0638 0.2223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0488 0.1297
Loa Loa (eye worm) cysteine protease 0.0102 0.1394 0.3705
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2384 0.6334
Brugia malayi hypothetical protein 0.0016 0.0016 0.0042
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0638 0.2223
Giardia lamblia Hypothetical protein 0.0023 0.0123 0.0394
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0638 0.3073
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0023 0.0123 0.0618
Brugia malayi Cathepsin L-like precursor 0.007 0.0879 0.2335
Brugia malayi PHD-finger family protein 0.0026 0.0168 0.0447
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0159 0.0886
Loa Loa (eye worm) hypothetical protein 0.0023 0.0123 0.0326
Schistosoma mansoni cathepsin S (C01 family) 0.0023 0.0123 0.0137
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0036 0.0326 0.1341
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.1087 0.1214
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3762 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0102 0.1394 0.3698
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.1607 0.4273
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0102 0.1394 0.3698
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.002 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0073 0.0922 0.2442
Plasmodium falciparum serine repeat antigen 7 0.0023 0.0123 0.0618
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0023 0.0123 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Echinococcus multilocularis cathepsin L cysteine protease 0.0102 0.1394 0.221
Loa Loa (eye worm) MBCTL1 0.0107 0.1468 0.3901
Giardia lamblia Cathepsin L precursor 0.0023 0.0123 0.0394
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0271 0.084
Loa Loa (eye worm) hypothetical protein 0.007 0.0879 0.2335
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0284 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0184 0.2706 0.3021
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0123 0.0326
Leishmania major cathepsin L-like protease 0.0147 0.2124 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0036 0.0326 0.0363
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0313 0.0496
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0326 0.1341
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0055 0.0638 0.0712
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0102 0.1394 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0668 0.1059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0135 0.0359
Loa Loa (eye worm) hypothetical protein 0.0032 0.0271 0.0719
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0724 0.0808
Onchocerca volvulus 0.0102 0.1394 0.562
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0529 0.1405
Echinococcus granulosus dnaJ subfamily B 0.0408 0.6308 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0023 0.0123 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0123 0.0316
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2384 0.6334
Echinococcus multilocularis cathepsin L 0.0055 0.0638 0.1012
Toxoplasma gondii cathepsin B 0.0073 0.0922 0.6495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3762 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1405
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0135 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3762 1
Onchocerca volvulus Chorion peroxidase homolog 0.0068 0.085 0.3214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Brugia malayi hypothetical protein 0.0228 0.3424 0.9102
Schistosoma mansoni peroxidasin 0.0068 0.085 0.0948
Mycobacterium ulcerans hypothetical protein 0.0024 0.0135 0.0096
Schistosoma mansoni ap endonuclease 0.0018 0.0047 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0359
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0107 0.1468 0.3901
Brugia malayi jmjC domain containing protein 0.006 0.0724 0.1923
Onchocerca volvulus 0.0102 0.1394 0.562
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0159 0.0832
Entamoeba histolytica cysteine protease, putative 0.0023 0.0123 0.0394
Loa Loa (eye worm) mbt repeat family protein 0.0094 0.1259 0.3348
Echinococcus granulosus cathepsin L cysteine protease 0.0055 0.0638 0.1012
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2526 0.671
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0023 0.0123 0.0618
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0049 0.0539 0.2367
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.013 0.0399
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.0922 0.1029
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0135 0.0112
Leishmania major cathepsin L-like protease 0.0147 0.2124 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0107 0.1468 0.2327
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0504 0.1339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0539 0.1423
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.013 0.0091
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0029 0.0078
Brugia malayi cathepsin L-like precursor 0.007 0.0879 0.2335
Echinococcus multilocularis cathepsin L cysteine protease 0.0102 0.1394 0.221
Onchocerca volvulus 0.0102 0.1394 0.562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0123 0.0326
Onchocerca volvulus 0.007 0.0879 0.3342
Echinococcus multilocularis cathepsin b 0.0184 0.2706 0.429
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0102 0.1394 0.3698
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0184 0.2706 0.3021
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0036 0.0326 0.1341
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0032 0.0271 0.0719
Brugia malayi Animal haem peroxidase family protein 0.0068 0.085 0.2258
Brugia malayi FAT domain containing protein 0.0015 0.0004 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Brugia malayi hypothetical protein 0.0025 0.0159 0.0423
Echinococcus granulosus cathepsin b 0.0184 0.2706 0.429
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.197 0.5233
Plasmodium vivax unspecified product 0.0055 0.0638 0.4422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.2124 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0135 0.0458
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0047 0.0059
Echinococcus multilocularis cpg binding protein 0.0032 0.0271 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0077 0.0194
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0102 0.1394 0.3698
Giardia lamblia Cathepsin B precursor 0.0073 0.0922 0.4548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.2124 1
Schistosoma mansoni bromodomain containing protein 0.0063 0.0763 0.0852
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0036 0.0326 0.1341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0023 0.0123 0.0618
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0036 0.0326 0.1047
Plasmodium falciparum serine repeat antigen 6 0.0023 0.0123 0.0618
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0054 0.0086
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0023 0.0123 0.0326
Echinococcus multilocularis serine protein kinase ATM 0.0049 0.0539 0.0854
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0102 0.1394 0.3705
Echinococcus granulosus cathepsin L cysteine proteinase 0.0102 0.1394 0.221
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0023 0.0123 0.0618
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.2124 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0131 0.0208
Echinococcus granulosus geminin 0.0333 0.5099 0.8083
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0023 0.0123 0.0618
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0023 0.0123 0.0137
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0036 0.0326 0.1341
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Brugia malayi Animal haem peroxidase family protein 0.0068 0.085 0.2258
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Entamoeba histolytica protein kinase rad3, putative 0.002 0.0077 0.0155
Loa Loa (eye worm) hypothetical protein 0.0228 0.3424 0.9102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0123 0.0316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.2124 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0102 0.1394 0.221
Schistosoma mansoni cathepsin C 0.0023 0.0123 0.0137
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0047 0.0059
Echinococcus granulosus polycomb protein SCMH1 0.0094 0.1259 0.1997
Echinococcus granulosus serine:threonine protein kinase SMG1 0.002 0.0077 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0023 0.0123 0.0316
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0123 0.0316
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0023 0.0123 0.0618
Onchocerca volvulus Peroxidase homolog 0.0068 0.085 0.3214
Brugia malayi Cathepsin L-like precursor 0.0102 0.1394 0.3705
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0326 0.0865
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0023 0.0123 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0488 0.0545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.2124 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0123 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0135 0.0096
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0135 0.0005
Onchocerca volvulus 0.0102 0.1394 0.562
Trypanosoma cruzi cysteine proteinase, putative 0.0055 0.0638 0.2223
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0015 0.0004 0.0006
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.3762 1
Onchocerca volvulus Peroxidasin homolog 0.0068 0.085 0.3214
Brugia malayi hypothetical protein 0.0068 0.085 0.2258
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0073 0.0922 0.4212
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0215 0.0573
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0107 0.1468 0.2327
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.197 0.5233
Loa Loa (eye worm) hypothetical protein 0.0094 0.1259 0.3348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.003 0.0033
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.013 0.0431
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0023 0.0123 0.0137
Giardia lamblia Fructose-bisphosphate aldolase 0.0138 0.197 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0488 0.0774
Trypanosoma cruzi cysteine protease, putative 0.0055 0.0638 0.2223
Loa Loa (eye worm) hypothetical protein 0.0068 0.0852 0.2266
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0359
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0326 0.1047
Loa Loa (eye worm) hypothetical protein 0.0102 0.1394 0.3705
Giardia lamblia Cathepsin B precursor 0.0023 0.0123 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0077 0.0194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.197 0.5233
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0123 0.0316
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.2124 0.781
Echinococcus multilocularis geminin 0.0333 0.5099 0.8083
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.003 0.0047
Entamoeba histolytica cysteine proteinase, putative 0.0102 0.1394 0.7002
Loa Loa (eye worm) hypothetical protein 0.0107 0.1468 0.3901
Echinococcus multilocularis peroxidasin 0.0068 0.085 0.1347
Loa Loa (eye worm) hypothetical protein 0.0184 0.2706 0.7193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0638 0.1687
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0159 0.0421
Schistosoma mansoni hypothetical protein 0.0333 0.5099 0.5692
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0023 0.0123 0.0137
Schistosoma mansoni cpg binding protein 0.0032 0.0271 0.0303
Echinococcus multilocularis histone acetyltransferase MYST2 0.0107 0.1468 0.2327
Brugia malayi Cathepsin L-like precursor 0.0102 0.1394 0.3705
Echinococcus granulosus SAM and MBT domain containing protein 0.0094 0.1259 0.1997
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0668 0.0745
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.2124 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0159 0.0423
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.2124 0.781
Onchocerca volvulus 0.0068 0.085 0.3214
Entamoeba histolytica cysteine protease, putative 0.0023 0.0123 0.0394
Brugia malayi Cathepsin L-like precursor 0.0102 0.1394 0.3705
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0023 0.0123 0.0137
Leishmania major cathepsin L-like protease 0.0102 0.1394 0.6485
Giardia lamblia Cysteine protease 0.0023 0.0123 0.0394
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.3762 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0036 0.0326 0.1341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.2124 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.1394 0.3698
Onchocerca volvulus Peroxidase homolog 0.0068 0.085 0.3214
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0135 0.0096
Giardia lamblia Cathepsin L-like protease 0.0023 0.0123 0.0394
Loa Loa (eye worm) fibroinase 0.0102 0.1394 0.3705
Echinococcus multilocularis cysteine protease 0.0102 0.1394 0.221
Entamoeba histolytica cysteine proteinase 2 0.0055 0.0638 0.3073
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0023 0.0123 0.0316
Plasmodium vivax unspecified product 0.0032 0.0271 0.1709
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0131 0.0208
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0036 0.0326 0.0516
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0094 0.1259 0.1406
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.013 0.0399
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.1087 0.1724
Toxoplasma gondii cathepsin CPC2 0.0023 0.0123 0.0562
Echinococcus granulosus histone acetyltransferase MYST2 0.0107 0.1468 0.2327
Toxoplasma gondii cathepsin CPC1 0.0023 0.0123 0.0562
Brugia malayi MH2 domain containing protein 0.0115 0.1607 0.4273
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0047 0.0125
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0036 0.0326 0.0516
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0075 0.02
Schistosoma mansoni myelin transcription factor 1 myt1 0.0107 0.1468 0.1638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.2124 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0159 0.0886
Entamoeba histolytica cysteine protease, putative 0.0023 0.0123 0.0394
Giardia lamblia Cathepsin B precursor 0.0023 0.0123 0.0394
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0326 0.1341
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0049 0.0539 0.0601
Brugia malayi Cathepsin L-like cysteine proteinase 0.007 0.0879 0.2335
Schistosoma mansoni cathepsin s 0.0032 0.0271 0.0302
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0023 0.0123 0.0326
Leishmania major cathepsin L-like protease 0.0102 0.1394 0.6485
Schistosoma mansoni cathepsin F (C01 family) 0.007 0.0879 0.0981
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0077 0.0194
Onchocerca volvulus Dual oxidase homolog 0.0068 0.085 0.3214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0638 0.2846
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.197 0.5233
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2384 0.6334
Entamoeba histolytica cysteine protease, putative 0.0023 0.0123 0.0394
Echinococcus granulosus zinc finger protein 0.0021 0.0085 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.2124 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0879 0.2327
Schistosoma mansoni cathepsin F (C01 family) 0.0102 0.1394 0.1556
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0123 0.0326
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.1087 0.289
Brugia malayi cathepsin B-like cysteine proteinase 0.0184 0.2706 0.7193
Entamoeba histolytica hypothetical protein 0.0049 0.0539 0.2556
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0023 0.0123 0.0394
Brugia malayi Animal haem peroxidase family protein 0.0068 0.085 0.2258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Entamoeba histolytica cysteine protease, putative 0.0102 0.1394 0.7002
Trypanosoma cruzi major cysteine proteinase, putative 0.0068 0.0853 0.303
Loa Loa (eye worm) hypothetical protein 0.0068 0.085 0.2258
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0115 0.1609 0.5872
Onchocerca volvulus 0.0029 0.0215 0.0409
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0023 0.0123 0.0618
Plasmodium vivax vivapain-1 0.0055 0.0638 0.4422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0102 0.1394 0.3698
Brugia malayi Animal haem peroxidase family protein 0.0068 0.085 0.2258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Giardia lamblia Cysteine protease 0.0023 0.0123 0.0394
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0023 0.0123 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.2124 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0138 0.197 0.5233
Brugia malayi cathepsin L-like cysteine proteinase 0.0023 0.0123 0.0326
Loa Loa (eye worm) hypothetical protein 0.007 0.0879 0.2335
Giardia lamblia GTOR 0.0036 0.0326 0.1448
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2384 0.6334
Plasmodium vivax vivapain-2 0.0102 0.1394 1
Giardia lamblia Cathepsin L-like protease 0.0023 0.0123 0.0394
Loa Loa (eye worm) hypothetical protein 0.0083 0.1087 0.289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0123 0.0316
Entamoeba histolytica cysteine protease, putative 0.0055 0.0638 0.3073
Brugia malayi cathepsin Z-like cysteine proteinase 0.0023 0.0123 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0114 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0326 0.0856
Loa Loa (eye worm) hypothetical protein 0.0037 0.0351 0.0932
Loa Loa (eye worm) hypothetical protein 0.0023 0.0123 0.0326
Schistosoma mansoni sex comb on midleg homolog 0.0094 0.1259 0.1406

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.045 nM Inhibition of human recombinant cathepsin K after 30 mins by spectrophotometric assay ChEMBL. 21128614
Ki (binding) = 0.19 nM Inhibition of human cathepsin S after 30 mins by spectrophotometric assay ChEMBL. 21128614
Ki (binding) = 2 nM Inhibition of human recombinant cathepsin L after 30 mins by spectrophotometric assay ChEMBL. 21128614
Ki (binding) = 2.4 nM Inhibition of human recombinant cathepsin B after 30 mins by spectrophotometric assay ChEMBL. 21128614

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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