Detailed information for compound 1507961

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 260.285 | Formula: C15H16O4
  • H donors: 1 H acceptors: 2 LogP: -0.06 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1O[C@@H]2C3=C1[C@H]1C[C@H]1[C@]3(C)C[C@H]1C2=C(C)C(=O)O1
  • InChi: 1S/C15H16O4/c1-5-9-8(18-13(5)16)4-15(2)7-3-6(7)10-11(15)12(9)19-14(10)17/h6-8,12,14,17H,3-4H2,1-2H3/t6-,7+,8-,12-,14-,15-/m0/s1
  • InChiKey: IIFNVNIPMCRQPC-YIEVAYSQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0449 0.1223 0.2029
Loa Loa (eye worm) heterochromatin protein 1 0.0045 0.0012 0.0022
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0122 0.0241 0.0241
Echinococcus multilocularis Sterile alpha motif SAM 0.0099 0.0174 0.0288
Loa Loa (eye worm) hypothetical protein 0.0099 0.0174 0.033
Schistosoma mansoni hypothetical protein 0.0061 0.0059 0.0059
Brugia malayi Associated with TFs and helicases family protein 0.0045 0.0012 0.0022
Loa Loa (eye worm) CHromoDomain protein family member 0.0106 0.0195 0.037
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0127 0.0258 0.6432
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0028 0.0052
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0099 0.0174 0.0288
Echinococcus multilocularis chromobox protein 1 0.0045 0.0012 0.002
Onchocerca volvulus 0.0099 0.0174 0.033
Echinococcus granulosus polycomb protein SCMH1 0.1044 0.3013 0.4997
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0176 0.0292
Brugia malayi M-phase phosphoprotein, mpp8 0.0045 0.0012 0.0022
Schistosoma mansoni phd finger protein 0.0061 0.0059 0.0059
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0059 0.0113
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0591 0.098
Schistosoma mansoni hypothetical protein 0.0099 0.0174 0.0174
Onchocerca volvulus 0.0061 0.0059 0.0113
Echinococcus granulosus SAM and MBT domain containing protein 0.1513 0.4419 0.7329
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0022
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0073 0.0121
Schistosoma mansoni Protein aveugle 0.0099 0.0174 0.0174
Echinococcus multilocularis polycomb protein SCMH1 0.1044 0.3013 0.4997
Echinococcus multilocularis Zinc finger, DBF type 0.0061 0.0059 0.0098
Brugia malayi SET domain containing protein 0.0061 0.0059 0.0113
Echinococcus multilocularis sodium and chloride dependent glycine 0.0122 0.0241 0.04
Loa Loa (eye worm) hypothetical protein 0.0238 0.0591 0.1121
Toxoplasma gondii hypothetical protein 0.0122 0.0241 0.599
Loa Loa (eye worm) hypothetical protein 0.0099 0.0174 0.033
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0059 0.124
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Echinococcus granulosus serotonin transporter 0.0716 0.2027 0.3361
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0059 0.2932
Echinococcus multilocularis histone acetyltransferase MYST2 0.0377 0.1007 0.1671
Onchocerca volvulus 0.0045 0.0012 0.0022
Brugia malayi PHD-finger family protein 0.0061 0.0059 0.0113
Brugia malayi hypothetical protein 0.0099 0.0174 0.033
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0022
Onchocerca volvulus 0.0122 0.0241 0.0457
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0122 0.0241 0.599
Echinococcus granulosus remodeling and spacing factor 1 0.0061 0.0059 0.0098
Loa Loa (eye worm) hypothetical protein 0.0122 0.0241 0.0457
Onchocerca volvulus 0.0117 0.0227 0.043
Echinococcus multilocularis Chromobox protein 3 0.0045 0.0012 0.002
Brugia malayi SET domain containing protein 0.0045 0.0012 0.0022
Toxoplasma gondii hypothetical protein 0.0122 0.0241 0.599
Trichomonas vaginalis inhibitor of growth, putative 0.0061 0.0059 0.2932
Echinococcus multilocularis liprin alpha 2 0.0099 0.0174 0.0288
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0045 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0122 0.0241 0.0457
Loa Loa (eye worm) norepinephrine transporter 0.0716 0.2027 0.3844
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0122 0.0241 0.0457
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0591 0.098
Brugia malayi chromobox protein homolog 3 0.0045 0.0012 0.0022
Echinococcus granulosus sphingomyelin synthase protein 1 0.0099 0.0174 0.0288
Loa Loa (eye worm) hypothetical protein 0.0099 0.0174 0.033
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0122 0.0241 0.04
Onchocerca volvulus 0.0122 0.0241 0.0457
Echinococcus granulosus Chromo domain 0.0045 0.0012 0.002
Echinococcus multilocularis zinc finger protein 0.0061 0.0059 0.0098
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0106 0.0195 0.0324
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0012 0.0022
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0073 0.0121
Schistosoma mansoni hypothetical protein 0.0049 0.0022 0.0022
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0122 0.0241 0.0241
Echinococcus granulosus sodium and chloride dependent glycine 0.0122 0.0241 0.04
Schistosoma mansoni zinc finger protein 0.0061 0.0059 0.0059
Echinococcus multilocularis sodium and chloride dependent glycine 0.0122 0.0241 0.04
Brugia malayi PHD-finger family protein 0.0061 0.0059 0.0113
Echinococcus granulosus TAF3 RNA polymerase II TATA box binding protein 0.0061 0.0059 0.0098
Brugia malayi Liprin-alpha 2 0.0099 0.0174 0.033
Onchocerca volvulus 0.0061 0.0059 0.0113
Schistosoma mansoni dpf3 0.0061 0.0059 0.0059
Schistosoma mansoni P2X receptor subunit 0.0066 0.0073 0.0073
Onchocerca volvulus Tankyrase homolog 0.0099 0.0174 0.033
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0022
Trypanosoma cruzi Kinesin-13 5, putative 0.0099 0.0174 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0122 0.0241 0.0457
Echinococcus granulosus histone acetyltransferase myst4 0.0061 0.0059 0.0098
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0022
Echinococcus multilocularis uro adherence factor A 0.0061 0.0059 0.0098
Echinococcus granulosus sodium and chloride dependent glycine 0.0122 0.0241 0.04
Brugia malayi jmjC domain containing protein 0.0538 0.1493 0.2832
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0377 0.1007 0.1671
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.1797 0.5273 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0012 0.0022
Echinococcus granulosus histone acetyltransferase MYST2 0.0377 0.1007 0.1671
Loa Loa (eye worm) solute carrier family 6 member 4 0.0716 0.2027 0.3844
Loa Loa (eye worm) jmjC domain-containing protein 0.0538 0.1493 0.2832
Loa Loa (eye worm) hypothetical protein 0.1797 0.5273 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0716 0.2027 0.3844
Schistosoma mansoni chromobox protein 0.0045 0.0012 0.0012
Brugia malayi Shank2E 0.0099 0.0174 0.033
Schistosoma mansoni fyve-containing 0.0061 0.0059 0.0059
Brugia malayi PHD-finger family protein 0.0061 0.0059 0.0113
Schistosoma mansoni P2X receptor subunit 0.0066 0.0073 0.0073
Toxoplasma gondii SWI2/SNF2-containing PHD finger protein 0.0061 0.0059 0.124
Schistosoma mansoni phd finger protein 0.016 0.0357 0.0357
Brugia malayi mbt repeat family protein 0.1797 0.5273 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.2049 0.603 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.1513 0.4419 0.4419
Schistosoma mansoni bromodomain containing protein 0.0061 0.0059 0.0059
Schistosoma mansoni sex comb on midleg homolog 0.1044 0.3013 0.3013
Echinococcus granulosus pdz domain containing protein 0.0099 0.0174 0.0288
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.1286 0.3739 0.6201
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0045 0.0012 0.002
Brugia malayi hypothetical protein 0.0061 0.0059 0.0113
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0122 0.0241 0.599
Schistosoma mansoni PHD zinc finger protein XAP135-related 0.0061 0.0059 0.0059
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0176 0.0292
Plasmodium falciparum EELM2 domain-containing protein, putative 0.0061 0.0059 0.207
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0059 0.2932
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0061 0.0059 0.0098
Schistosoma mansoni hypothetical protein 0.0045 0.0012 0.0012
Echinococcus multilocularis liprin alpha 2 0.0099 0.0174 0.0288
Echinococcus granulosus PHD and RING finger domain containing protein 1 0.0061 0.0059 0.0098
Loa Loa (eye worm) hypothetical protein 0.0099 0.0174 0.033
Schistosoma mansoni hypothetical protein 0.0061 0.0059 0.0059
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0028 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0059 0.2932
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Brugia malayi PHD-finger family protein 0.0061 0.0059 0.0113
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0061 0.0059 0.0098
Plasmodium vivax JmjC domain containing protein 0.0114 0.0219 0.9048
Brugia malayi hypothetical protein 0.0099 0.0174 0.033
Loa Loa (eye worm) hypothetical protein 0.0122 0.0241 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0059 0.2932
Schistosoma mansoni hypothetical protein 0.0061 0.0059 0.0059
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0061 0.0059 0.0059
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0122 0.0241 0.0241
Schistosoma mansoni myst-related protein 0.0061 0.0059 0.0059
Echinococcus granulosus Sterile alpha motif SAM 0.0099 0.0174 0.0288
Schistosoma mansoni sodium/chloride dependent transporter 0.0122 0.0241 0.0241
Echinococcus granulosus PHD finger protein 14 0.0061 0.0059 0.0098
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0099 0.0174 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Loa Loa (eye worm) hypothetical protein 0.0716 0.2027 0.3844
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0061 0.0059 0.0059
Echinococcus granulosus chromobox protein 2 0.0775 0.2202 0.3653
Trichomonas vaginalis cgi-62, putative 0.0099 0.0174 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Schistosoma mansoni spingomyelin synthetase-related 0.0099 0.0174 0.0174
Schistosoma mansoni zinc finger protein 0.0061 0.0059 0.0059
Loa Loa (eye worm) MBCTL1 0.0377 0.1007 0.1911
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0128 0.0261 0.0433
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0377 0.1007 0.1671
Echinococcus multilocularis PHD finger protein 14 0.0061 0.0059 0.0098
Echinococcus multilocularis chromobox protein 2 0.0775 0.2202 0.3653
Loa Loa (eye worm) hypothetical protein 0.0099 0.0174 0.033
Plasmodium falciparum SNF2 helicase, putative 0.0061 0.0059 0.207
Brugia malayi Carm1-pending protein 0.0128 0.0261 0.0495
Schistosoma mansoni myelin transcription factor 1 myt1 0.0377 0.1007 0.1007
Echinococcus granulosus geminin 0.0166 0.0374 0.062
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0059 0.124
Loa Loa (eye worm) AIDA-1b 0.0099 0.0174 0.033
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0059 0.207
Echinococcus multilocularis SAM and MBT domain containing protein 0.1513 0.4419 0.7329
Echinococcus multilocularis remodeling and spacing factor 1 0.0061 0.0059 0.0098
Brugia malayi PHD-finger family protein 0.0061 0.0059 0.0113
Schistosoma mansoni survival motor neuron protein 0.0049 0.0022 0.0022
Echinococcus multilocularis geminin 0.0166 0.0374 0.062
Echinococcus granulosus histone acetyltransferase myst3 0.016 0.0357 0.0592
Schistosoma mansoni protein arginine n-methyltransferase 0.0128 0.0261 0.0261
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0227 0.043
Brugia malayi PHD-finger family protein 0.0061 0.0059 0.0113
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Schistosoma mansoni myst histone acetyltransferase 0.0061 0.0059 0.0059
Schistosoma mansoni sodium/chloride dependent transporter 0.0716 0.2027 0.2027
Echinococcus granulosus zinc finger protein 0.0061 0.0059 0.0098
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0122 0.0241 0.5
Brugia malayi Hypothetical C28H8.9 in chromosome III 0.0061 0.0059 0.0113
Echinococcus multilocularis pdz domain containing protein 0.0099 0.0174 0.0288
Loa Loa (eye worm) serotonin transporter b 0.0716 0.2027 0.3844
Echinococcus multilocularis phd finger protein 10 0.0061 0.0059 0.0098
Echinococcus multilocularis Sterile alpha motif type 0.0099 0.0174 0.0288
Onchocerca volvulus 0.0045 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0122 0.0241 0.0457
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0022 0.0042
Brugia malayi cask-interacting protein 2 0.0099 0.0174 0.033
Loa Loa (eye worm) hypothetical protein 0.005 0.0028 0.0052
Schistosoma mansoni requim req/dpf2 0.0061 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0099 0.0174 0.0174
Plasmodium falciparum transporter, putative 0.0122 0.0241 1
Schistosoma mansoni bromodomain containing protein 0.0061 0.0059 0.0059
Schistosoma mansoni sodium/chloride dependent transporter 0.0122 0.0241 0.0241
Echinococcus multilocularis TAF3 RNA polymerase II, TATA box binding protein 0.0061 0.0059 0.0098
Giardia lamblia Kinesin-13 0.0099 0.0174 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0022
Schistosoma mansoni sodium-dependent amino acid transporter 0.0122 0.0241 0.0241
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0099 0.0174 0.0288
Brugia malayi Bromodomain associated family protein 0.0061 0.0059 0.0113
Brugia malayi hypothetical protein 0.0238 0.0591 0.1121
Schistosoma mansoni P2X receptor subunit 0.0066 0.0073 0.0073
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0099 0.0174 0.0288
Schistosoma mansoni hypothetical protein 0.0061 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0716 0.2027 0.3844
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0122 0.0241 0.0457
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0122 0.0241 0.0457
Schistosoma mansoni amine GPCR 0.0349 0.0925 0.0925
Giardia lamblia Giardia trophozoite antigen GTA-1 0.0099 0.0174 0.5
Echinococcus granulosus chromobox protein 1 0.0045 0.0012 0.002
Schistosoma mansoni zinc finger protein 0.0061 0.0059 0.0059
Onchocerca volvulus 0.0122 0.0241 0.0457
Brugia malayi hypothetical protein 0.0045 0.0012 0.0022
Onchocerca volvulus 0.0061 0.0059 0.0113
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0122 0.0241 0.04
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0073 0.0121
Echinococcus multilocularis polyhomeotic protein 2 0.0099 0.0174 0.0288
Schistosoma mansoni jumonji/arid domain-containing protein 0.0366 0.0975 0.0975
Onchocerca volvulus 0.0061 0.0059 0.0113
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0122 0.0241 0.04
Echinococcus multilocularis histone acetyltransferase myst4 0.0061 0.0059 0.0098
Trypanosoma cruzi Kinesin-13 5, putative 0.0099 0.0174 1
Onchocerca volvulus 0.0099 0.0174 0.033
Onchocerca volvulus 0.0099 0.0174 0.033
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0045 0.0012 0.0012
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0122 0.0241 0.04
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0022
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0099 0.0174 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0174 0.033
Onchocerca volvulus 0.0061 0.0059 0.0113
Brugia malayi hypothetical protein 0.0061 0.0059 0.0113
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.1286 0.3739 0.6201
Toxoplasma gondii hypothetical protein 0.0101 0.0178 0.4342
Brugia malayi bicaudal-C 0.0099 0.0174 0.033
Loa Loa (eye worm) hypothetical protein 0.0122 0.0241 0.0457
Echinococcus granulosus polyhomeotic protein 2 0.0099 0.0174 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0059 0.2932
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0174 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0449 0.1223 0.2029
Plasmodium falciparum amino acid transporter, putative 0.0122 0.0241 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0114 0.0219 0.9048
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0045 0.0012 0.0022
Schistosoma mansoni hepatitis B virus X associated protein hbxa 0.0061 0.0059 0.0059
Loa Loa (eye worm) helicase 0.0045 0.0012 0.0022
Schistosoma mansoni chromobox protein 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0122 0.0241 0.0457
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0377 0.1007 0.1911
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0099 0.0174 0.0288
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0099 0.0174 0.0174
Echinococcus granulosus cpg binding protein 0.0061 0.0059 0.0098
Loa Loa (eye worm) mbt repeat family protein 0.1087 0.314 0.5956
Brugia malayi CHD4 protein 0.0106 0.0195 0.037
Loa Loa (eye worm) tnks protein 0.0099 0.0174 0.033
Brugia malayi Bromodomain containing protein 0.0061 0.0059 0.0113
Plasmodium vivax amine transporter, putative 0.0122 0.0241 1
Loa Loa (eye worm) hypothetical protein 0.0716 0.2027 0.3844
Brugia malayi mbt repeat family protein 0.1087 0.314 0.5956
Loa Loa (eye worm) F/Y-rich family protein 0.0061 0.0059 0.0113
Loa Loa (eye worm) hypothetical protein 0.0122 0.0241 0.0457
Brugia malayi hypothetical protein 0.0122 0.0241 0.0457
Treponema pallidum sodium- and chloride- dependent transporter 0.0716 0.2027 0.5
Onchocerca volvulus 0.0049 0.0022 0.0042
Brugia malayi F/Y-rich N-terminus family protein 0.0061 0.0059 0.0113
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0028 0.0052
Schistosoma mansoni hypothetical protein 0.0166 0.0374 0.0374
Onchocerca volvulus 0.1186 0.3438 0.652
Schistosoma mansoni polyhomeotic 0.0099 0.0174 0.0174
Schistosoma mansoni Protein aveugle 0.0099 0.0174 0.0174
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0045 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Brugia malayi AIDA-1b 0.0099 0.0174 0.033
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0122 0.0241 0.599
Toxoplasma gondii PLU-1 family protein 0.0173 0.0395 1
Plasmodium falciparum zinc finger protein, putative 0.0061 0.0059 0.207
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0059 0.2932
Onchocerca volvulus 0.0099 0.0174 0.033
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0099 0.0174 0.0288
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0073 0.0121
Schistosoma mansoni SET domain protein 0.0061 0.0059 0.0059
Echinococcus multilocularis histone acetyltransferase myst3 0.016 0.0357 0.0592
Plasmodium vivax hypothetical protein, conserved 0.0122 0.0241 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0174 0.033
Schistosoma mansoni chromobox protein 0.0045 0.0012 0.0012
Brugia malayi Protein cec-1. 0.0045 0.0012 0.0022
Echinococcus granulosus Zinc finger DBF type 0.0061 0.0059 0.0098
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0022
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0122 0.0241 0.0241
Onchocerca volvulus 0.0045 0.0012 0.0022
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0122 0.0241 0.04
Schistosoma mansoni lip-related protein (liprin) alpha 0.0099 0.0174 0.0174
Schistosoma mansoni hypothetical protein 0.0166 0.0374 0.0374
Trypanosoma cruzi hypothetical protein 0.0099 0.0174 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0122 0.0241 0.0457
Echinococcus granulosus liprin alpha 2 0.0099 0.0174 0.0288
Echinococcus granulosus phd finger protein 12 0.0061 0.0059 0.0098
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0073 0.0121
Entamoeba histolytica hypothetical protein 0.0061 0.0059 1
Brugia malayi Heterochromatin protein 1 0.0045 0.0012 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0059 0.2932
Schistosoma mansoni cpg binding protein 0.0061 0.0059 0.0059
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0045 0.0012 0.0012
Echinococcus granulosus Chromobox protein 3 0.0045 0.0012 0.002
Toxoplasma gondii AP2 domain transcription factor AP2VIIa-7 0.0061 0.0059 0.124
Echinococcus multilocularis phd finger protein 12 0.0061 0.0059 0.0098
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0122 0.0241 0.0241
Brugia malayi Valyl-tRNA synthetase 0.0045 0.0012 0.0022
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0122 0.0241 0.0241
Schistosoma mansoni cpg binding protein 0.0061 0.0059 0.0059
Onchocerca volvulus 0.0716 0.2027 0.3844
Echinococcus granulosus chromobox protein 1 0.0045 0.0012 0.002
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0099 0.0174 0.033
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0099 0.0174 1
Brugia malayi coiled-coil like protein 1 0.0099 0.0174 0.033
Echinococcus multilocularis lysine specific demethylase 5A 0.0305 0.0791 0.1312
Echinococcus multilocularis PHD and RING finger domain containing protein 1 0.0061 0.0059 0.0098
Onchocerca volvulus 0.0099 0.0174 0.033
Schistosoma mansoni DNAj-like protein 0.0099 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Plasmodium falciparum histone-lysine N-methyltransferase, H3 lysine-4 specific 0.0061 0.0059 0.207
Schistosoma mansoni jumonji domain containing protein 0.01 0.0176 0.0176
Schistosoma mansoni jumonji/arid domain-containing protein 0.0366 0.0975 0.0975
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0022
Schistosoma mansoni chromobox protein 0.0775 0.2202 0.2202
Plasmodium vivax SNF2 family N-terminal domain containing protein 0.0061 0.0059 0.207
Schistosoma mansoni sex comb on midleg homolog 0.1044 0.3013 0.3013
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Schistosoma mansoni hypothetical protein 0.1286 0.3739 0.3739
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0073 0.0121
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0099 0.0174 0.033
Echinococcus granulosus lysine specific demethylase 5A 0.0366 0.0975 0.1616
Echinococcus multilocularis chromobox protein 1 0.0045 0.0012 0.002
Echinococcus multilocularis serotonin transporter 0.0716 0.2027 0.3361
Loa Loa (eye worm) Carm1-pending protein 0.0128 0.0261 0.0495
Schistosoma mansoni myst-related protein 0.0061 0.0059 0.0059
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0059 0.0098
Echinococcus granulosus phd finger protein 10 0.0061 0.0059 0.0098
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0716 0.2027 0.2027
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0059 0.124
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.2049 0.603 1
Echinococcus granulosus liprin alpha 2 0.0099 0.0174 0.0288
Echinococcus granulosus lysine specific demethylase 5B 0.0061 0.0059 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0059 0.2932
Onchocerca volvulus 0.0099 0.0174 0.033
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Loa Loa (eye worm) hypothetical protein 0.0099 0.0174 0.033
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0106 0.0195 0.0324
Brugia malayi jmjC domain containing protein 0.01 0.0176 0.0334
Schistosoma mansoni P2X receptor subunit 0.0066 0.0073 0.0073
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0059 0.0098
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0128 0.0261 0.0433
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0106 0.0195 0.0195
Echinococcus multilocularis Chromo domain 0.0045 0.0012 0.002
Plasmodium vivax protein kinase, putative 0.0099 0.0174 0.706
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0061 0.0059 0.0098
Echinococcus granulosus Sterile alpha motif type 0.0099 0.0174 0.0288
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0227 0.043
Echinococcus multilocularis cpg binding protein 0.0061 0.0059 0.0098
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0122 0.0241 0.0241
Echinococcus multilocularis lysine specific demethylase 5B 0.0061 0.0059 0.0098
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0128 0.0261 0.6512
Brugia malayi MH2 domain containing protein 0.0117 0.0227 0.043
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0059 0.124
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0122 0.0241 0.04
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0122 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0061 0.0059 0.0113
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0122 0.0241 0.0457
Brugia malayi Sphingomyelin synthase-related 1 0.0099 0.0174 0.033
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0122 0.0241 0.04
Echinococcus granulosus uro adherence factor A 0.0061 0.0059 0.0098
Loa Loa (eye worm) hypothetical protein 0.0377 0.1007 0.1911
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0059 0.0113
Echinococcus granulosus fetal alzheimer antigen falz 0.0061 0.0059 0.0098

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) < 10 uM Cytotoxicity against human HepG2 cells by MTT assay ChEMBL. 21142110
IC50 (functional) < 10 uM Cytotoxicity against human OS-RC2 cells by MTT assay ChEMBL. 21142110
IC50 (functional) < 10 uM Cytotoxicity against human A549 cells by MTT assay ChEMBL. 21142110
IC50 (functional) < 10 uM Cytotoxicity against human SKOV3 cells by MTT assay ChEMBL. 21142110
IC50 (functional) < 10 uM Cytotoxicity against human HeLa cells by MTT assay ChEMBL. 21142110
IC50 (functional) < 10 uM Cytotoxicity against human MCF7 cells by MTT assay ChEMBL. 21142110
IC50 (functional) < 10 uM Cytotoxicity against human SGC7901 cells by MTT assay ChEMBL. 21142110
IC50 (functional) < 10 uM Cytotoxicity against human LoVo cells by MTT assay ChEMBL. 21142110

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21142110

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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