TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 152.194 | Formula: C8H12N2O
H donors: 3 H acceptors: 1 LogP: -0.11 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: NNC[C@H](c1ccccc1)O
InChi: 1S/C8H12N2O/c9-10-6-8(11)7-4-2-1-3-5-7/h1-5,8,10-11H,6,9H2/t8-/m1/s1
InChiKey: KSOOBHGJJYAGNP-MRVPVSSYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	amine oxidase, copper containing 3	Starlite/ChEMBL	References
Rattus norvegicus	Monoamine oxidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	one of two likely peroxisomal copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171
Echinococcus multilocularis	amiloride sensitive amine oxidase	Get druggable targets OG5_127171	All targets in OG5_127171
Schistosoma japonicum	IPR000269,Copper amine oxidase,domain-containing	Get druggable targets OG5_127171	All targets in OG5_127171
Neospora caninum	hypothetical protein	Get druggable targets OG5_127171	All targets in OG5_127171
Schistosoma mansoni	copper/topaquinone oxidase	Get druggable targets OG5_127171	All targets in OG5_127171
Echinococcus granulosus	amiloride sensitive amine oxidase	Get druggable targets OG5_127171	All targets in OG5_127171
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_127171	All targets in OG5_127171
Candida albicans	one of two likely peroxisomal copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171
Cryptosporidium parvum	extracellular protein with a signal peptide sequence, MAM domain and a Cu amine oxidase domain	Get druggable targets OG5_127171	All targets in OG5_127171
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127171	All targets in OG5_127171
Schistosoma japonicum	ko:K00276 copper amine oxidase [EC1.4.3.6], putative	Get druggable targets OG5_127171	All targets in OG5_127171
Candida albicans	one of two likely copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171
Cryptosporidium hominis	amiloride binding protein 1	Get druggable targets OG5_127171	All targets in OG5_127171
Candida albicans	one of two likely copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	amine oxidase, flavin-containing family protein	Monoamine oxidase	526 aa	464 aa	21.6 %
Dictyostelium discoideum	amine oxidase	Monoamine oxidase	526 aa	491 aa	31.0 %
Dictyostelium discoideum	hypothetical protein	Monoamine oxidase	526 aa	524 aa	22.9 %
Dictyostelium discoideum	hypothetical protein	Monoamine oxidase	526 aa	518 aa	22.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0041
Onchocerca volvulus		0.0297	0.0648	0.3879
Loa Loa (eye worm)	hypothetical protein	0.0297	0.0648	0.0648
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3034	0.764	0.9137
Brugia malayi	Plexin repeat family protein	0.0697	0.1671	0.1671
Trichomonas vaginalis	conserved hypothetical protein	0.0642	0.1529	1
Echinococcus multilocularis		0.0051	0.0019	0.0023
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Echinococcus granulosus	exocyst complex component 2	0.013	0.0222	0.0266
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0051	0.0019	0.0023
Trypanosoma cruzi	aurora B kinase, putative	0.0074	0.0078	0.9597
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1529	0.1529
Loa Loa (eye worm)	Plekhf2 protein	0.0059	0.0041	0.0041
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0075	0.0081	1
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	centaurin/arf, putative	0.0059	0.0041	0.0266
Brugia malayi	PXA domain containing protein	0.0642	0.1529	0.1529
Entamoeba histolytica	hypothetical protein	0.013	0.0222	0.1454
Toxoplasma gondii	hypothetical protein	0.0059	0.0041	0.5
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.013	0.0222	0.1454
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0059	0.0041	0.0049
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Brugia malayi	serine/threonine-protein kinase 6	0.0074	0.0078	0.0078
Loa Loa (eye worm)	syntrophin-1	0.0059	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.013	0.0222	0.0222
Echinococcus granulosus	myotubularin protein 13	0.0059	0.0041	0.0049
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0075	0.0081	0.0081
Echinococcus granulosus	regulator of G protein signaling 3	0.0642	0.1529	0.1829
Entamoeba histolytica	hypothetical protein	0.0642	0.1529	1
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0059	0.0041	0.0266
Schistosoma mansoni	axis inhibition protein axin	0.0642	0.1529	0.1529
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0075	0.0081	1
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0078	0.051
Trypanosoma cruzi	PH domain containing protein, putative	0.0059	0.0041	0.5
Brugia malayi	DNA-binding protein LAG-1	0.013	0.0222	0.0222
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0075	0.0081	1
Brugia malayi	hypothetical protein	0.0051	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0049
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0078	0.051
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0081	0.0531
Schistosoma mansoni	serine/threonine protein kinase	0.3034	0.764	0.764
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Schistosoma mansoni	nephrin	0.0067	0.0062	0.0062
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0051	0.0019	0.2366
Brugia malayi	PXA domain containing protein	0.0642	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0041	0.0266
Brugia malayi	PH domain containing protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.3317	0.8361	0.8361
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0051	0.0019	0.5
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0059	0.0041	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0642	0.1529	1
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0059	0.0041	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Echinococcus multilocularis	Pleckstrin y	0.0059	0.0041	0.0049
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0642	0.1529	0.1529
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0051	0.0019	0.0019
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0074	0.0078	0.9597
Entamoeba histolytica	hypothetical protein	0.013	0.0222	0.1454
Echinococcus multilocularis	neuroglian	0.0062	0.0049	0.0059
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0048	0.0012	0.0015
Echinococcus multilocularis	expressed protein	0.0642	0.1529	0.1829
Entamoeba histolytica	PH domain containing protein	0.0059	0.0041	0.0266
Entamoeba histolytica	hypothetical protein	0.0075	0.0081	0.0531
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0059	0.0041	0.5
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0074	0.0078	0.0093
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0059	0.0041	0.5
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0059	0.0041	0.0243
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.0222	0.1454
Echinococcus granulosus	semaphorin 1A	0.0297	0.0648	0.0775
Echinococcus multilocularis	transcription factor collier	0.013	0.0222	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0297	0.0648	0.0648
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0059	0.0041	0.5
Echinococcus multilocularis	regulator of G protein signaling 3	0.0642	0.1529	0.1829
Echinococcus granulosus	Regulator of G protein signaling 20	0.0642	0.1529	0.1829
Mycobacterium ulcerans	dehydrogenase	0.0051	0.0019	0.5
Onchocerca volvulus		0.0059	0.0041	0.0243
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0041	0.0266
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0075	0.0081	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0041	0.0266
Echinococcus multilocularis	actin binding protein anillin	0.0059	0.0041	0.0049
Brugia malayi	PH domain containing protein	0.0059	0.0041	0.0041
Echinococcus granulosus	regulator of G protein signaling 3	0.0642	0.1529	0.1829
Brugia malayi	Variant SH3 domain containing protein	0.0059	0.0041	0.0041
Echinococcus granulosus	activin receptor type	0.0059	0.0041	0.0049
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0059	0.0041	0.0049
Toxoplasma gondii	histone lysine-specific demethylase	0.0051	0.0019	0.2366
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0051	0.0019	0.0023
Echinococcus granulosus	beta 1 syntrophin	0.0059	0.0041	0.0049
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0051	0.0019	0.5
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0059	0.0041	0.0049
Leishmania major	serine/threonine-protein kinase a, putative	0.0075	0.0081	1
Echinococcus granulosus	cytohesin 1	0.0059	0.0041	0.0049
Trichomonas vaginalis	kinesin light chain, putative	0.0059	0.0041	0.0266
Schistosoma mansoni	ephrin receptor	0.0048	0.0012	0.0012
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0075	0.0081	1
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0051	0.0019	0.2366
Brugia malayi	Pleckstrin Homology Domain	0.0059	0.0041	0.0041
Toxoplasma gondii	AtPH1 family protein	0.0059	0.0041	0.5
Echinococcus granulosus	defective proboscis extension response	0.0062	0.0049	0.0059
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0062	0.0049	0.0049
Toxoplasma gondii	Oxysterol-binding protein	0.0059	0.0041	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0059	0.0041	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0062	0.0062
Echinococcus granulosus	Pleckstrin y	0.0059	0.0041	0.0049
Schistosoma mansoni	plexin	0.0697	0.1671	0.1671
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.0222	0.1454
Schistosoma mansoni	axis inhibition protein axin	0.0642	0.1529	0.1529
Loa Loa (eye worm)	AUR protein kinase	0.0074	0.0078	0.0078
Echinococcus granulosus	DCC interacting protein 13 beta	0.0059	0.0041	0.0049
Brugia malayi	Uncoordinated protein 104	0.0059	0.0041	0.0041
Echinococcus granulosus	plexin a4	0.0827	0.2003	0.2396
Schistosoma mansoni	amine oxidase	0.0051	0.0019	0.0019
Brugia malayi	Protein kinase domain containing protein	0.0293	0.0638	0.0638
Schistosoma mansoni	fibrocystin l	0.013	0.0222	0.0222
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Onchocerca volvulus		0.0059	0.0041	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0049
Giardia lamblia	Aurora kinase	0.0074	0.0078	1
Echinococcus multilocularis	oxysterol binding protein 3	0.0059	0.0041	0.0049
Schistosoma mansoni	regulator of G protein signaling	0.0642	0.1529	0.1529
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.3317	0.8361	0.8361
Trichomonas vaginalis	conserved hypothetical protein	0.0642	0.1529	1
Echinococcus granulosus	oxysterol binding protein 9	0.0059	0.0041	0.0049
Trypanosoma cruzi	hypothetical protein	0.0059	0.0041	0.5
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0075	0.0081	1
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0059	0.0041	0.0266
Entamoeba histolytica	protein kinase, putative	0.0074	0.0078	0.051
Loa Loa (eye worm)	plexin A	0.0827	0.2003	0.2003
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0041
Echinococcus granulosus	oxysterol binding protein 3	0.0059	0.0041	0.0049
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0059	0.0041	0.0049
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0067	0.0062	0.0062
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0051	0.0019	0.0019
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0642	0.1529	0.1829
Schistosoma mansoni	regulator of G protein signaling	0.0642	0.1529	0.1529
Echinococcus multilocularis	oxysterol binding protein 9	0.0059	0.0041	0.0049
Entamoeba histolytica	hypothetical protein	0.0059	0.0041	0.0266
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0059	0.0041	0.5
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0051	0.0019	0.5
Echinococcus multilocularis	Pleckstrin y	0.0059	0.0041	0.0049
Leishmania major	protein kinase, putative	0.0075	0.0081	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0041	0.0266
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0075	0.0081	1
Schistosoma mansoni	dynamin	0.0059	0.0041	0.0041
Brugia malayi	PH domain containing protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	sema domain-containing protein	0.0297	0.0648	0.0648
Entamoeba histolytica	protein kinase, putative	0.0075	0.0081	0.0531
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0075	0.0081	1
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Trypanosoma cruzi	NIMA-related kinase, putative	0.0075	0.0081	1
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Schistosoma mansoni	zinc finger protein	0.0059	0.0041	0.0041
Brugia malayi	plexin A	0.0827	0.2003	0.2003
Trichomonas vaginalis	conserved hypothetical protein	0.0642	0.1529	1
Echinococcus multilocularis	regulator of G protein signaling	0.0642	0.1529	0.1829
Loa Loa (eye worm)	uncoordinated protein 104	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0049
Echinococcus granulosus	Pleckstrin y	0.0059	0.0041	0.0049
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0059	0.0041	0.0266
Schistosoma mansoni	hypothetical protein	0.0059	0.0041	0.0041
Toxoplasma gondii	hypothetical protein	0.0059	0.0041	0.5
Loa Loa (eye worm)	oxysterol binding protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1529	0.1529
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Brugia malayi	Sema domain containing protein	0.0297	0.0648	0.0648
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0642	0.1529	0.1829
Brugia malayi	Oxysterol binding protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	Immunoglobulin	0.0062	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.013	0.0222	0.0222
Brugia malayi	regulator of G-protein signaling rgs-7	0.0642	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0019	0.0019
Echinococcus granulosus	axis inhibition protein axin	0.0642	0.1529	0.1829
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0081	0.0531
Loa Loa (eye worm)	cytohesin 3	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trypanosoma brucei	protein kinase, putative	0.0059	0.0041	0.5
Echinococcus granulosus	Oxysterol binding protein 11	0.0059	0.0041	0.0049
Onchocerca volvulus		0.0059	0.0041	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0019	0.0019
Schistosoma mansoni	hypothetical protein	0.013	0.0222	0.0222
Schistosoma mansoni	serine/threonine protein kinase	0.3034	0.764	0.764
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0051	0.0019	0.0023
Brugia malayi	TBC domain containing protein	0.0059	0.0041	0.0041
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.3317	0.8361	0.8361
Leishmania major	protein kinase, putative	0.0075	0.0081	1
Echinococcus granulosus	Pleckstrin y	0.0059	0.0041	0.0049
Plasmodium falciparum	PH domain-containing protein, putative	0.0059	0.0041	0.5
Entamoeba histolytica	hypothetical protein	0.0642	0.1529	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0059	0.0041	0.0266
Schistosoma mansoni	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0642	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.013	0.0222	0.1454
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.0041	0.5
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0059	0.0041	0.0049
Entamoeba histolytica	protein kinase, putative	0.0075	0.0081	0.0531
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0059	0.0041	0.0041
Mycobacterium ulcerans	oxidoreductase	0.0051	0.0019	0.5
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1529	0.1529
Echinococcus granulosus	twitchin	0.0078	0.009	0.0107
Echinococcus granulosus	expressed protein	0.0642	0.1529	0.1829
Onchocerca volvulus		0.0059	0.0041	0.0243
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0075	0.0081	0.0531
Echinococcus granulosus	pleckstrin y domain containing family A	0.0059	0.0041	0.0049
Entamoeba histolytica	protein kinase, putative	0.0075	0.0081	0.0531
Plasmodium vivax	hypothetical protein, conserved	0.0059	0.0041	0.5
Echinococcus granulosus	pdz domain containing protein	0.0059	0.0041	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Schistosoma mansoni	zinc finger protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0059	0.0041	0.5
Schistosoma mansoni	protein kinase	0.0074	0.0078	0.0078
Schistosoma mansoni	oxysterol-binding protein 1	0.0059	0.0041	0.0041
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0059	0.0041	0.0049
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0041	0.0266
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.3317	0.8361	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.0041	0.5
Schistosoma mansoni	hypothetical protein	0.0401	0.0913	0.0913
Brugia malayi	hypothetical protein	0.0067	0.0062	0.0062
Leishmania major	UDP-galactopyranose mutase	0.0051	0.0019	0.2366
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0059	0.0041	0.0049
Echinococcus multilocularis	amiloride sensitive amine oxidase	0.0103	0.0154	0.0184
Echinococcus multilocularis	plexin a4	0.0827	0.2003	0.2396
Entamoeba histolytica	hypothetical protein	0.0059	0.0041	0.0266
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Schistosoma mansoni	amine oxidase	0.0051	0.0019	0.0019
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0059	0.0041	0.0041
Entamoeba histolytica	protein kinase, putative	0.0074	0.0078	0.051
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0074	0.0078	0.0093
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.013	0.0222	0.1454
Onchocerca volvulus		0.0059	0.0041	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.013	0.0222	0.0222
Schistosoma mansoni	centaurin alpha	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0062	0.0062
Entamoeba histolytica	protein kinase domain containing protein	0.0173	0.0332	0.2171
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0401	0.0913	0.0913
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0059	0.0041	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0642	0.1529	1
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0062	0.0049	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2393	0.6	0.7177
Echinococcus multilocularis	axis inhibition protein axin	0.0642	0.1529	0.1829
Loa Loa (eye worm)	hypothetical protein	0.0297	0.0648	0.0648
Echinococcus multilocularis	regulator of G protein signaling 7	0.0642	0.1529	0.1829
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Brugia malayi	Probable exocyst complex component Sec5	0.013	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trypanosoma cruzi	NIMA-related kinase, putative	0.0075	0.0081	1
Echinococcus multilocularis	activin receptor type	0.0059	0.0041	0.0049
Brugia malayi	hypothetical protein	0.0297	0.0648	0.0648
Schistosoma mansoni	regulator of G protein signaling	0.0642	0.1529	0.1529
Echinococcus multilocularis	hypothetical protein	0.0297	0.0648	0.0775
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Plasmodium falciparum	protein kinase, putative	0.0059	0.0041	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0078	0.051
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.0222	0.1454
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Schistosoma mansoni	hypothetical protein	0.0297	0.0648	0.0648
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0081	0.0531
Brugia malayi	probable spectrin beta chain	0.0059	0.0041	0.0041
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0075	0.0081	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0019	0.0019
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0059	0.0041	0.0041
Brugia malayi	Variant SH3 domain containing protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trypanosoma cruzi	PH domain containing protein, putative	0.0059	0.0041	0.5
Onchocerca volvulus		0.0697	0.1671	1
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.0041	0.0266
Echinococcus multilocularis	beta 1 syntrophin	0.0059	0.0041	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	growth factor receptor-bound protein	0.0059	0.0041	0.0041
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0059	0.0041	0.0041
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0051	0.0019	0.2366
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Schistosoma mansoni	goodpasture antigen-binding protein	0.0059	0.0041	0.0041
Entamoeba histolytica	hypothetical protein	0.0059	0.0041	0.0266
Echinococcus multilocularis	aurora kinase A	0.0074	0.0078	0.0093
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0059	0.0041	0.0266
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0041	0.0266
Entamoeba histolytica	PH domain containing protein	0.0059	0.0041	0.0266
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0642	0.1529	1
Echinococcus granulosus	amiloride sensitive amine oxidase	0.0103	0.0154	0.0184
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0078	0.051
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0075	0.0081	1
Loa Loa (eye worm)	AUR protein kinase	0.0074	0.0078	0.0078
Echinococcus multilocularis	cytohesin 1	0.0059	0.0041	0.0049
Brugia malayi	serine/threonine protein kinase 6	0.0074	0.0078	0.0078
Brugia malayi	hypothetical protein	0.0297	0.0648	0.0648
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0059	0.0041	0.0049
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0642	0.1529	0.1529
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0059	0.0041	0.0266
Entamoeba histolytica	p21-activated kinase	0.0075	0.0081	0.0531
Echinococcus granulosus	serine/threonine protein kinase	0.0075	0.0081	0.0097
Trypanosoma brucei	PH domain containing protein, putative	0.0059	0.0041	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0059	0.0041	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0059	0.0041	0.0049
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0059	0.0041	0.0049
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0059	0.0041	0.0049
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Entamoeba histolytica	tyrosin kinase, putative	0.0173	0.0332	0.2171
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0297	0.0648	0.0648
Plasmodium vivax	hypothetical protein, conserved	0.0051	0.0019	0.2366
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Brugia malayi	PH domain containing protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0062	0.0049	0.0059
Echinococcus multilocularis	exocyst complex component 2	0.013	0.0222	0.0266
Echinococcus multilocularis	oxysterol binding protein 1	0.0059	0.0041	0.0049
Trichomonas vaginalis	centaurin beta, putative	0.0059	0.0041	0.0266
Echinococcus granulosus	axis inhibition protein axin	0.0642	0.1529	0.1829
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0075	0.0081	1
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0075	0.0081	0.0531
Schistosoma mansoni	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus granulosus	transcription factor collier	0.013	0.0222	0.0266
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0059	0.0041	0.5
Entamoeba histolytica	protein kinase, putative	0.0075	0.0081	0.0531
Brugia malayi	IPT/TIG domain containing protein	0.013	0.0222	0.0222
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0059	0.0041	0.0041
Leishmania major	folate/biopterin transporter, putative	0.0075	0.0081	1
Mycobacterium ulcerans	monoamine oxidase	0.0051	0.0019	0.5
Loa Loa (eye worm)	hypothetical protein	0.022	0.0452	0.0452
Entamoeba histolytica	cell surface protease gp63, putative	0.013	0.0222	0.1454
Brugia malayi	Fibronectin type III domain containing protein	0.0067	0.0062	0.0062
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0041	0.0266
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0074	0.0078	0.051
Loa Loa (eye worm)	AUR protein kinase	0.0074	0.0078	0.0078
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0041	0.0266
Entamoeba histolytica	hypothetical protein	0.013	0.0222	0.1454
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0075	0.0081	1
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0059	0.0041	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Schistosoma mansoni	serine/threonine-protein kinase	0.0075	0.0081	0.0081
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2393	0.6	0.7177
Trypanosoma cruzi	hypothetical protein	0.0059	0.0041	0.5
Echinococcus multilocularis	Oxysterol binding protein 11	0.0059	0.0041	0.0049
Schistosoma mansoni	z-protein (S1r protein)	0.0642	0.1529	0.1529
Schistosoma mansoni	semaphorin 5-related	0.0297	0.0648	0.0648
Trypanosoma cruzi	Protein kinase B	0.0075	0.0081	1
Entamoeba histolytica	hypothetical protein	0.0059	0.0041	0.0266
Plasmodium vivax	PH domain containing protein	0.0059	0.0041	0.5
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0059	0.0041	0.0266
Echinococcus granulosus	Rho GTPase activating protein 24	0.0059	0.0041	0.0049
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0041
Brugia malayi	PH domain containing protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0059	0.0041	0.0049
Entamoeba histolytica	hypothetical protein	0.0059	0.0041	0.0266
Trichomonas vaginalis	centaurin/arf, putative	0.0059	0.0041	0.0266
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0059	0.0041	0.0266
Mycobacterium tuberculosis	Possible oxidoreductase	0.0051	0.0019	0.5
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0051	0.0019	0.5
Trypanosoma cruzi	hypothetical protein	0.0059	0.0041	0.5
Echinococcus multilocularis	semaphorin 5B	0.0297	0.0648	0.0775
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0059	0.0041	0.0049
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0297	0.0648	0.0648
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0075	0.0081	1
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0059	0.0041	0.0049
Onchocerca volvulus	Putative zinc finger protein	0.0059	0.0041	0.0243
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0074	0.0078	0.051
Onchocerca volvulus	Protein melted homolog	0.0059	0.0041	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0049
Schistosoma mansoni	regulator of G protein signaling	0.0642	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0049
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0642	0.1529	0.1529
Loa Loa (eye worm)	PXA domain-containing protein	0.0642	0.1529	0.1529
Echinococcus granulosus	neuroglian	0.0062	0.0049	0.0059
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.3317	0.8361	1
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0075	0.0081	1
Brugia malayi	hypothetical protein	0.0642	0.1529	0.1529
Echinococcus multilocularis	myotubularin protein 13	0.0059	0.0041	0.0049
Echinococcus granulosus	regulator of G protein signaling 7	0.0642	0.1529	0.1829
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1529	0.1529
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Loa Loa (eye worm)	hypothetical protein	0.013	0.0222	0.0222
Loa Loa (eye worm)	TK/ALK protein kinase	0.0293	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0105	0.0159	0.0159
Plasmodium falciparum	oxysterol-binding protein, putative	0.0059	0.0041	0.5
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0059	0.0041	0.0049
Entamoeba histolytica	hypothetical protein	0.013	0.0222	0.1454
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0019	0.0019
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0059	0.0041	0.0266
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0081	0.0531
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0642	0.1529	0.1829
Entamoeba histolytica	hypothetical protein	0.0642	0.1529	1
Trichomonas vaginalis	protein transport protein sec7, putative	0.0059	0.0041	0.0266
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0075	0.0081	1
Brugia malayi	serine/threonine kinase 12	0.0074	0.0078	0.0078
Echinococcus granulosus	semaphorin 5B	0.0297	0.0648	0.0775
Onchocerca volvulus		0.0051	0.0019	0.0115
Toxoplasma gondii	hypothetical protein	0.0052	0.0023	0.2862
Schistosoma mansoni	protein kinase	0.0059	0.0041	0.0041
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3034	0.764	0.764
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0059	0.0041	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Plasmodium falciparum	protoporphyrinogen oxidase	0.0051	0.0019	0.2366
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0081	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0059	0.0041	0.0049
Loa Loa (eye worm)	RGS-3 protein	0.0642	0.1529	0.1529
Trypanosoma cruzi	hypothetical protein	0.0059	0.0041	0.5
Onchocerca volvulus		0.0059	0.0041	0.0243
Echinococcus granulosus	dynamin 1	0.0059	0.0041	0.0049
Schistosoma mansoni	copper/topaquinone oxidase	0.0103	0.0154	0.0154
Schistosoma mansoni	vesicular amine transporter	0.0065	0.0056	0.0056
Trypanosoma brucei	protein kinase, putative	0.0075	0.0081	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0642	0.1529	0.1829
Trypanosoma cruzi	hypothetical protein	0.0059	0.0041	0.5
Schistosoma mansoni	rho gtpase activating protein	0.0059	0.0041	0.0041
Brugia malayi	A-kinase anchor protein 10, precursor	0.0642	0.1529	0.1529
Echinococcus multilocularis	dynamin 1	0.0059	0.0041	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0075	0.0081	0.0081
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0062	0.0049	0.0059
Schistosoma mansoni	cell adhesion molecule	0.0067	0.0062	0.0062
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trypanosoma cruzi	hypothetical protein	0.0059	0.0041	0.5
Schistosoma mansoni	plexin	0.0401	0.0913	0.0913
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0074	0.0078	0.9597
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Schistosoma mansoni	serine/threonine-protein kinase	0.0075	0.0081	0.0081
Leishmania major	protein kinase, putative	0.0074	0.0078	0.9597
Echinococcus multilocularis	Immunoglobulin	0.0062	0.0049	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1529	0.1529
Trichomonas vaginalis	conserved hypothetical protein	0.0642	0.1529	1
Brugia malayi	Plekhf2 protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0105	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0019	0.0019
Brugia malayi	PH domain containing protein	0.0059	0.0041	0.0041
Trypanosoma brucei	aurora B kinase	0.0074	0.0078	0.9597
Loa Loa (eye worm)	hypothetical protein	0.0697	0.1671	0.1671
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0051	0.0019	0.2366
Echinococcus granulosus	oxysterol binding protein 1	0.0059	0.0041	0.0049
Echinococcus multilocularis	rac serine:threonine kinase	0.0075	0.0081	0.0097
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.013	0.0222	0.1454
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0075	0.0081	1
Brugia malayi	Cadps2 protein	0.0059	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0103	0.0154	0.0154
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0062	0.0062
Brugia malayi	Oxysterol-binding protein	0.0059	0.0041	0.0041
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0059	0.0041	0.0243
Echinococcus multilocularis	regulator of G protein signaling 3	0.0642	0.1529	0.1829
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0059	0.0041	0.0049
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0051	0.0019	0.2366
Trichomonas vaginalis	protein transport protein sec7, putative	0.0059	0.0041	0.0266
Schistosoma mansoni	syntrophin	0.0059	0.0041	0.0041
Echinococcus granulosus	calcium dependent secretion activator 1	0.0059	0.0041	0.0049
Leishmania major	hypothetical protein, conserved	0.0059	0.0041	0.5
Trichomonas vaginalis	hypothetical protein	0.0059	0.0041	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.0222	0.1454
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0059	0.0041	0.0049
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3034	0.764	0.9137
Plasmodium vivax	hypothetical protein, conserved	0.0051	0.0019	0.2366
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0075	0.0081	1
Brugia malayi	PH domain containing protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	alpha chimerin, putative	0.0059	0.0041	0.0266
Echinococcus multilocularis	pdz domain containing protein	0.0059	0.0041	0.0049
Leishmania major	protein kinase, putative	0.0059	0.0041	0.5
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0059	0.0041	0.5
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0051	0.0019	0.5
Brugia malayi	PH domain containing protein	0.0059	0.0041	0.0041
Echinococcus granulosus	Immunoglobulin	0.0062	0.0049	0.0059
Entamoeba histolytica	protein kinase, putative	0.0075	0.0081	0.0531
Brugia malayi	PH domain containing protein	0.0059	0.0041	0.0041
Onchocerca volvulus		0.0059	0.0041	0.0243
Brugia malayi	Dynamin	0.0059	0.0041	0.0041
Brugia malayi	MAX-1A	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0059	0.0041	0.5
Schistosoma mansoni	hypothetical protein	0.0297	0.0648	0.0648
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0075	0.0081	1
Loa Loa (eye worm)	sema domain-containing protein	0.0297	0.0648	0.0648
Schistosoma mansoni	myotubularin-related protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.0222	0.1454
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0059	0.0041	0.5
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0059	0.0041	0.0049
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trypanosoma cruzi	PH domain containing protein, putative	0.0059	0.0041	0.5
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0051	0.0019	0.2366
Trichomonas vaginalis	centaurin gamma, putative	0.0059	0.0041	0.0266
Brugia malayi	regulator of G-protein signaling egl-10	0.0642	0.1529	0.1529
Trypanosoma cruzi	hypothetical protein	0.0059	0.0041	0.5
Brugia malayi	hypothetical protein	0.0642	0.1529	0.1529
Entamoeba histolytica	PH domain containing protein	0.0059	0.0041	0.0266
Entamoeba histolytica	protein kinase, putative	0.0075	0.0081	0.0531
Entamoeba histolytica	hypothetical protein	0.0075	0.0081	0.0531
Entamoeba histolytica	protein kinase, putative	0.0075	0.0081	0.0531
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0051	0.0019	0.2366
Brugia malayi	amine oxidase, flavin-containing family protein	0.0051	0.0019	0.0019
Echinococcus multilocularis	Pleckstrin y	0.0059	0.0041	0.0049
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0059	0.0041	0.0049
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0051	0.0019	0.5
Schistosoma mansoni	vav2	0.0059	0.0041	0.0041
Echinococcus granulosus	roundabout 2	0.0067	0.0062	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.0222	0.1454
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0041	0.0266
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0059	0.0041	0.5
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0075	0.0081	1
Toxoplasma gondii	aurora kinase	0.0074	0.0078	0.9597
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0048	0.0012	0.0015
Onchocerca volvulus	outspread protein homolog	0.0059	0.0041	0.0243
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0059	0.0041	0.0266
Trichomonas vaginalis	centaurin alpha, putative	0.0059	0.0041	0.0266
Brugia malayi	SWIRM domain containing protein	0.0051	0.0019	0.0019
Loa Loa (eye worm)	PH domain-containing protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	roundabout 2	0.0067	0.0062	0.0074
Schistosoma mansoni	oxysterol-binding protein 1	0.0059	0.0041	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0078	0.051
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Toxoplasma gondii	protein kinase domain-containing protein	0.0075	0.0081	1
Leishmania major	hypothetical protein, conserved	0.0059	0.0041	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0075	0.0081	0.0531
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0075	0.0081	0.0531
Trypanosoma cruzi	PH domain containing protein, putative	0.0059	0.0041	0.5
Brugia malayi	Dynamin	0.0059	0.0041	0.0041
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0078	0.0078
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0059	0.0041	0.0049
Schistosoma mansoni	hypothetical protein	0.0059	0.0041	0.0041
Entamoeba histolytica	hypothetical protein, conserved	0.0059	0.0041	0.0266
Echinococcus multilocularis	axis inhibition protein axin	0.0642	0.1529	0.1829
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0049	0.0049
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0059	0.0041	0.0266
Loa Loa (eye worm)	hypothetical protein	0.013	0.0222	0.0222
Schistosoma mansoni	goodpasture antigen-binding protein	0.0059	0.0041	0.0041
Schistosoma mansoni	regulator of G protein signaling	0.0642	0.1529	0.1529
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0642	0.1529	0.1529
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.013	0.0222	0.1454
Brugia malayi	Sema domain containing protein	0.0297	0.0648	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0019	0.0019
Echinococcus multilocularis	regulator of G protein signaling 7	0.0642	0.1529	0.1829
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0074	0.0078	0.051
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.0222	0.1454
Brugia malayi	Syntrophin-1	0.0059	0.0041	0.0041
Schistosoma mansoni	dynamin	0.0059	0.0041	0.0041
Echinococcus granulosus	GRB2 associated binding protein 3	0.0059	0.0041	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0297	0.0648	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Entamoeba histolytica	protein kinase , putative	0.0074	0.0078	0.051
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	rho-GTPase-activating	0.0059	0.0041	0.0041
Echinococcus granulosus	aurora kinase A	0.0074	0.0078	0.0093
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0051	0.0019	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Brugia malayi	Cytohesin 3	0.0059	0.0041	0.0041
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0642	0.1529	0.1529

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.15 uM	Inhibition of human recombinant VAP-1 expressed in CHO cells after 30 mins by coupled colorimetric method	ChEMBL.	21405023
IC50 (binding)	= 9.8 uM	Inhibition of rat liver MAO-A/MAO-B after 30 mins by coupled colorimetric method	ChEMBL.	21405023

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1766381

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1510206