Detailed information for compound 1530181

Basic information

Technical information
  • TDR Targets ID: 1530181
  • Name: 2-[2,4-dioxo-3-(2-phenylethyl)-[1]benzothiolo [2,3-e]pyrimidin-1-yl]-N-(3-methylphenyl)acet amide
  • MW: 469.555 | Formula: C27H23N3O3S
  • H donors: 1 H acceptors: 3 LogP: 5.39 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)NC(=O)Cn1c(=O)n(CCc2ccccc2)c(=O)c2c1c1ccccc1s2
  • InChi: 1S/C27H23N3O3S/c1-18-8-7-11-20(16-18)28-23(31)17-30-24-21-12-5-6-13-22(21)34-25(24)26(32)29(27(30)33)15-14-19-9-3-2-4-10-19/h2-13,16H,14-15,17H2,1H3,(H,28,31)
  • InChiKey: MUOQODRKBRTTCK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2,4-dioxo-3-(2-phenylethyl)benzothiopheno[2,3-e]pyrimidin-1-yl]-N-(3-methylphenyl)acetamide
  • 2-[2,4-dioxo-3-(2-phenylethyl)-1-benzothiopheno[2,3-e]pyrimidinyl]-N-(3-methylphenyl)acetamide
  • 2-[2,4-diketo-3-(2-phenylethyl)benzothiopheno[2,3-e]pyrimidin-1-yl]-N-(3-methylphenyl)acetamide
  • 2-[2,4-dioxo-3-(2-phenylethyl)-[1]benzothiolo[2,3-e]pyrimidin-1-yl]-N-(3-methylphenyl)ethanamide
  • NCGC00111472-01
  • C688-1042

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ran, putative 0.0021 0.003 0.0156
Schistosoma mansoni hypothetical protein 0.0043 0.0103 0.0102
Loa Loa (eye worm) hypothetical protein 0.0066 0.0175 0.0174
Loa Loa (eye worm) solute carrier family 6 member 4 0.1132 0.3605 0.3605
Schistosoma mansoni neurotransmitter gated ion channel 0.0056 0.0144 0.0143
Loa Loa (eye worm) hypothetical protein 0.0032 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Toxoplasma gondii hypothetical protein 0.0192 0.0581 0.2688
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0191 0.0577 0.0577
Brugia malayi Serotonin receptor 0.004 0.0093 0.0092
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0061 0.016 0.0867
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.1035 0.5645
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0104 0.0557
Brugia malayi AKH receptor 0.004 0.0093 0.0092
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0192 0.0581 0.0581
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0061 0.016 0.0736
Trypanosoma brucei trypanothione reductase 0.0038 0.0085 0.0099
Loa Loa (eye worm) hypothetical protein 0.0066 0.0175 0.0174
Echinococcus multilocularis g protein coupled receptor 0.004 0.0093 0.0093
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0118 0.0117
Loa Loa (eye worm) TYRA-2 protein 0.004 0.0093 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.1035 0.5645
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.002 0.0027 0.0377
Loa Loa (eye worm) hypothetical protein 0.1319 0.4208 0.4208
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Onchocerca volvulus 0.004 0.0093 0.0253
Schistosoma mansoni nardilysin (M16 family) 0.0024 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0151 0.045 0.045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0093 0.0092
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Brugia malayi beta-NAC-like protein 0.0034 0.0074 0.0073
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0215 0.0215
Echinococcus multilocularis glycine receptor subunit beta 0.0122 0.0356 0.0356
Brugia malayi regulatory protein 0.0044 0.0104 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0022 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0093 0.0093
Brugia malayi neuropeptide F receptor 0.004 0.0093 0.0092
Leishmania major hypothetical protein, conserved 0.0325 0.1009 0.1217
Schistosoma mansoni cpg binding protein 0.0028 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0066 0.0175 0.0174
Brugia malayi hypothetical protein 0.004 0.0093 0.0092
Plasmodium falciparum transporter, putative 0.0192 0.0581 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0162 0.0162
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0003 0.0007
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0192 0.0581 0.0581
Onchocerca volvulus 0.0056 0.0144 0.0396
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.1035 0.5645
Brugia malayi hypothetical protein 0.024 0.0734 0.0734
Schistosoma mansoni nAChR subunit 0.0056 0.0144 0.0143
Brugia malayi hypothetical protein 0.0056 0.0144 0.0144
Toxoplasma gondii peptidase M16 inactive domain-containing protein 0.0014 0.0009 0.0034
Brugia malayi hypothetical protein 0.0056 0.0144 0.0144
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0056 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Echinococcus multilocularis g-protein coupled receptor 0.004 0.0093 0.0093
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0005 0.0003
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0061 0.016 0.019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0215 0.0215
Toxoplasma gondii bicoid-interacting protein BIN3 0.0061 0.016 0.0736
Onchocerca volvulus 0.0066 0.0175 0.048
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.016 0.0867
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0023 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0005 0.0003
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0061 0.016 0.019
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0192 0.0581 0.0581
Loa Loa (eye worm) T-complex protein 1 0.0024 0.004 0.0039
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0012 0.0001 0.0001
Brugia malayi putative neuropeptide receptor 0.004 0.0093 0.0092
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0001
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0005 0.0012
Brugia malayi hypothetical protein 0.0192 0.0581 0.0581
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0012 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0043 0.0722
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0074 0.0085
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Mycobacterium tuberculosis Possible methyltransferase 0.0044 0.0104 0.0979
Echinococcus multilocularis synaptic vesicular amine transporter 0.3118 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0056 0.0144 0.0144
Plasmodium falciparum glutathione reductase 0.0013 0.0005 0.0078
Brugia malayi Cation transporter family protein 0.0122 0.0356 0.0355
Onchocerca volvulus Alhambra homolog 0.0031 0.0062 0.0167
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.0093 0.0093
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0272 0.2187
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Trypanosoma cruzi squalene synthase, putative 0.1043 0.3319 0.4012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0325 0.1009 0.1009
Loa Loa (eye worm) insulin-degrading enzyme 0.0024 0.0039 0.0038
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.105 0.3343 0.3343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Echinococcus granulosus nardilysin 0.0024 0.0039 0.0039
Echinococcus granulosus hypothetical protein 0.004 0.0093 0.0093
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.002 0.0027 0.0217
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0061 0.016 0.016
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0003 0.0008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1581 0.5052 0.5052
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0025 0.0024
Echinococcus granulosus glutamate NMDA receptor subunit 0.0065 0.0174 0.0174
Schistosoma mansoni chromobox protein 0.0012 0.0002 0.0001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.0093 0.0093
Schistosoma mansoni sodium-dependent amino acid transporter 0.0192 0.0581 0.058
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.0093 0.0093
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.004 0.067
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0356 0.0355
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.076 0.0759
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0174 0.0174
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0093 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0581 0.1832 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0122 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.0553
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0043 0.0048
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.0093 0.0092
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0191 0.0577 0.0576
Schistosoma mansoni importin beta-1 0.0028 0.0054 0.0053
Brugia malayi hypothetical protein 0.0061 0.016 0.016
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.1596 0.8713
Brugia malayi G-protein coupled receptor 0.004 0.0093 0.0092
Schistosoma mansoni hypothetical protein 0.004 0.0093 0.0092
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.0093 0.0093
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.026 0.026
Echinococcus granulosus chromobox protein 2 0.0012 0.0002 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0093 0.0093
Mycobacterium tuberculosis Conserved protein 0.0044 0.0104 0.0979
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0023 0.0022
Echinococcus granulosus dna polymerase eta 0.0019 0.0023 0.0023
Onchocerca volvulus 0.0196 0.0594 0.1645
Leishmania major hypothetical protein, conserved 0.0025 0.0043 0.0048
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0074 0.0393
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0014 0.0009 0.0009
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0019 0.002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0093 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0248 0.076 0.0759
Leishmania major DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.0093 0.0092
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.0505
Brugia malayi hypothetical protein 0.004 0.0093 0.0092
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1132 0.3605 0.3604
Schistosoma mansoni hypothetical protein 0.004 0.0093 0.0092
Plasmodium vivax SET domain protein, putative 0.0062 0.0162 0.2783
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0043 0.0722
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.0356 0.0355
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0043 0.0191
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0066 0.0175 0.0174
Echinococcus multilocularis neuropeptide receptor 0.004 0.0093 0.0093
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.0093 0.0253
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0105 0.0566
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0002 0.0001
Trichomonas vaginalis dullard protein, putative 0.0012 0.0003 0.0008
Schistosoma mansoni hypothetical protein 0.0078 0.0215 0.0214
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.0093 0.0092
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0122 0.0356 0.0355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Trypanosoma cruzi peptidase, putative 0.0024 0.0039 0.0043
Schistosoma mansoni nAChR subunit 0.0122 0.0356 0.0355
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0122 0.0356 0.0355
Brugia malayi hypothetical protein 0.0016 0.0014 0.0014
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.003 0.003
Loa Loa (eye worm) GABA receptor subunit 0.0066 0.0175 0.0174
Loa Loa (eye worm) hypothetical protein 0.0025 0.0043 0.0042
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0002 0.0014
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0061 0.016 0.016
Leishmania major squalene synthase, putative 0.1043 0.3319 0.4012
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0093 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.1359 0.4337 0.4336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0191 0.0577 0.0576
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0196 0.0594 0.0594
Echinococcus granulosus nAChR subunit 0.0066 0.0175 0.0175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0022 0.0112
Chlamydia trachomatis insulinase family protease III 0.0024 0.0039 0.0581
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0122 0.0356 0.0356
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0005 0.002
Schistosoma mansoni jumonji domain containing protein 0.008 0.022 0.0219
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.0093 0.0093
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0174 0.0174
Brugia malayi Pre-SET motif family protein 0.0062 0.0162 0.0162
Loa Loa (eye worm) helicase 0.0012 0.0002 0.0001
Echinococcus multilocularis nardilysin 0.0014 0.0009 0.0009
Echinococcus multilocularis allatostatin A receptor 0.004 0.0093 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0022 0.0112
Onchocerca volvulus 0.004 0.0093 0.0253
Toxoplasma gondii insulysin, putative 0.0022 0.0035 0.0155
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0061 0.016 0.019
Leishmania major trypanothione reductase 0.0038 0.0085 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.1035 0.5645
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0002 0.0014
Schistosoma mansoni hypothetical protein 0.0169 0.0508 0.0507
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0019 0.002
Schistosoma mansoni vesicular amine transporter 0.3118 1 1
Onchocerca volvulus 0.004 0.0093 0.0253
Schistosoma mansoni ran 0.0021 0.003 0.0029
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.0936 0.0936
Echinococcus granulosus GPCR family 2 0.0078 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Giardia lamblia DINP protein human, muc B family 0.0019 0.0023 0.0109
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.0093 0.0092
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0007 0.0007
Trypanosoma brucei C-8 sterol isomerase, putative 0.258 0.8268 1
Leishmania major basic transcription factor 3a, putative 0.0034 0.0074 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0074 0.0393
Echinococcus multilocularis muscleblind protein 0.0151 0.045 0.045
Leishmania major C-8 sterol isomerase-like protein 0.258 0.8268 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0028 0.0052 0.0052
Trypanosoma cruzi target of rapamycin kinase 3 0.0017 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Onchocerca volvulus 0.004 0.0093 0.0253
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0056 0.0144 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Echinococcus multilocularis Chromo domain 0.0012 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0162 0.0162
Onchocerca volvulus 0.0192 0.0581 0.1609
Brugia malayi ERG2 and Sigma1 receptor like protein 0.258 0.8268 0.8268
Schistosoma mansoni hypothetical protein 0.0325 0.1009 0.1008
Echinococcus multilocularis neuropeptide receptor 0.004 0.0093 0.0093
Echinococcus multilocularis zinc finger transcription factor gli2 0.031 0.0961 0.0961
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0093 0.0093
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0142 0.0653
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Onchocerca volvulus 0.004 0.0093 0.0253
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0019 0.002
Echinococcus granulosus Chromo domain 0.0012 0.0002 0.0002
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0062 0.0061
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0061 0.016 0.019
Schistosoma mansoni DNA polymerase eta 0.0019 0.0023 0.0022
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0005 0.0003
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0044 0.0104 0.1771
Echinococcus granulosus muscleblind protein 0.0151 0.045 0.045
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0062 0.0279
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0022 0.0112
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0118 0.0117
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0241 0.2352
Loa Loa (eye worm) ACC-1 protein 0.0122 0.0356 0.0355
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0005 0.0003
Schistosoma mansoni amine GPCR 0.004 0.0093 0.0092
Onchocerca volvulus 0.0122 0.0356 0.0983
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0005 0.5
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0023 0.0117
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0241 0.2352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0062 0.0279
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0093 0.0092
Loa Loa (eye worm) Carm1-pending protein 0.0682 0.2158 0.2157
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0057 0.03
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0088 0.0088
Echinococcus granulosus importin subunit beta 1 0.0028 0.0054 0.0054
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0019 0.002
Schistosoma mansoni insulysin (M16 family) 0.0013 0.0005 0.0004
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0093 0.0093
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.0093 0.0092
Schistosoma mansoni myosin xvIII 0.004 0.0093 0.0092
Plasmodium vivax phosphoethanolamine N-methyltransferase 0.0044 0.0104 0.1771
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0019 0.002
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0074 0.1254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0118 0.0117
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0024 0.0039 0.0172
Brugia malayi hypothetical protein 0.0056 0.0144 0.0144
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0003 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0118 0.0118
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0023 0.0022
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0002 0.0014
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0192 0.0581 0.0581
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0093 0.0092
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0192 0.0581 0.0581
Schistosoma mansoni adenoreceptor 0.004 0.0093 0.0092
Toxoplasma gondii hypothetical protein 0.0192 0.0581 0.2688
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0095 0.026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0017 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.0356 0.0355
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.0148
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0065 0.0174 0.0174
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0241 0.2352
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0043 0.0722
Schistosoma mansoni hypothetical protein 0.0078 0.0215 0.0214
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0093 0.0093
Echinococcus granulosus insulin degrading enzyme 0.0024 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.1132 0.3605 0.3605
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Echinococcus multilocularis sodium and chloride dependent glycine 0.0192 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.003 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0093 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0093 0.0092
Brugia malayi Dopamine receptor 0.004 0.0093 0.0092
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.0093 0.0093
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0093 0.0093
Echinococcus granulosus chromobox protein 1 0.0073 0.0199 0.0199
Echinococcus multilocularis protein arginine methyltransferase 0.0044 0.0104 0.0104
Trichomonas vaginalis set domain proteins, putative 0.0487 0.1531 0.8355
Schistosoma mansoni hypothetical protein 0.1359 0.4337 0.4336
Echinococcus granulosus glutamate receptor 2 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus granulosus tm gpcr rhodopsin 0.105 0.3343 0.3343
Echinococcus multilocularis g protein coupled receptor 0.004 0.0093 0.0093
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0019 0.0018
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0002 0.0001
Echinococcus granulosus cpg binding protein 0.003 0.0059 0.0059
Echinococcus granulosus neuropeptide s receptor 0.004 0.0093 0.0093
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0088 0.0087
Schistosoma mansoni sodium/chloride dependent transporter 0.0192 0.0581 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Schistosoma mansoni neuropeptide receptor 0.004 0.0093 0.0092
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0023
Echinococcus multilocularis serotonin receptor 0.004 0.0093 0.0093
Schistosoma mansoni biogenic amine receptor 0.004 0.0093 0.0092
Echinococcus granulosus protein arginine N methyltransferase 8 0.0044 0.0104 0.0104
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0017 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.1132 0.3605 0.3605
Brugia malayi Transient-receptor-potential like protein 0.0038 0.0085 0.0085
Mycobacterium ulcerans phytoene synthase, CrtB 0.0325 0.1009 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0004 0.0002
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0122 0.0356 0.0355
Schistosoma mansoni neuropeptide receptor 0.004 0.0093 0.0092
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0122 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0078 0.0215 0.0215
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0033
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0093 0.0093
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.026 0.026
Echinococcus granulosus neuropeptide receptor 0.004 0.0093 0.0093
Echinococcus granulosus nmda type glutamate receptor 0.0028 0.0052 0.0052
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0066 0.0175 0.0174
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.0093 0.0093
Brugia malayi Bromodomain containing protein 0.0031 0.0062 0.0061
Brugia malayi hypothetical protein 0.0012 0.0002 0.0001
Echinococcus multilocularis nAChR subunit 0.0066 0.0175 0.0175
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.004 0.004
Echinococcus multilocularis cpg binding protein 0.003 0.0059 0.0059
Brugia malayi chromobox protein homolog 3 0.0041 0.0095 0.0095
Brugia malayi Importin beta-1 subunit 0.0028 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0078 0.0215 0.0214
Mycobacterium tuberculosis Probable reductase 0.0087 0.0241 0.2352
Loa Loa (eye worm) glutathione reductase 0.0038 0.0085 0.0085
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0009 0.0009
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.004 0.0039
Schistosoma mansoni opsin-like receptor 0.004 0.0093 0.0092
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.0093 0.0093
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.004 0.0044
Schistosoma mansoni transcription factor btf3 0.0034 0.0074 0.0073
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.0093 0.0093
Echinococcus multilocularis fmrfamide receptor 0.004 0.0093 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Onchocerca volvulus 0.004 0.0093 0.0253
Toxoplasma gondii sporozoite developmental protein 0.0024 0.0039 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0062 0.0061
Treponema pallidum sodium- and chloride- dependent transporter 0.1132 0.3605 1
Schistosoma mansoni amine GPCR 0.004 0.0093 0.0092
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0122 0.0356 0.0355
Echinococcus multilocularis chromobox protein 2 0.0012 0.0002 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.004 0.004
Entamoeba histolytica hypothetical protein 0.0023 0.0037 0.0193
Loa Loa (eye worm) hypothetical protein 0.0192 0.0581 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0037 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Brugia malayi Protein arginine N-methyltransferase 0.0061 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0192 0.0581 0.0581
Plasmodium falciparum glutathione reductase 0.0038 0.0085 0.1452
Onchocerca volvulus 0.004 0.0093 0.0253
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Brugia malayi jmjC domain containing protein 0.01 0.0286 0.0286
Echinococcus multilocularis serotonin transporter 0.1132 0.3605 0.3605
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0074 0.0201 0.02
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.0356 0.0355
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0043 0.0048
Trypanosoma cruzi squalene synthase, putative 0.1043 0.3319 0.4012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.0093 0.0092
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.0093 0.0093
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0074 0.0073
Mycobacterium ulcerans hypothetical protein 0.0044 0.0104 0.0979
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0284 0.0876 0.8673
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0507 0.1596 0.1596
Echinococcus granulosus transcription factor btf3 0.0034 0.0074 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0215 0.0215
Plasmodium falciparum thioredoxin reductase 0.0038 0.0085 0.1452
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0118 0.0117
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0005 0.0078
Brugia malayi Serotonin receptor 0.004 0.0093 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Schistosoma mansoni cpg binding protein 0.003 0.0059 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.1596 0.8713
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.004 0.0045
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0066 0.0175 0.0174
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.004 0.0177
Mycobacterium ulcerans trans-aconitate 2-methyltransferase 0.0044 0.0104 0.0979
Brugia malayi glutathione reductase 0.0038 0.0085 0.0085
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0062 0.1048
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0019 0.0019
Schistosoma mansoni transient receptor potential channel 0.0066 0.0174 0.0173
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.004 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Echinococcus granulosus serotonin receptor 0.004 0.0093 0.0093
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0003 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0005 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Brugia malayi CHD4 protein 0.0014 0.0007 0.0006
Echinococcus granulosus 3'partial|nardilysin 0.0024 0.0039 0.0039
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0192 0.0581 0.058
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0192 0.0581 0.058
Brugia malayi hypothetical protein 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Brugia malayi MH2 domain containing protein 0.012 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Echinococcus granulosus synaptic vesicular amine transporter 0.3118 1 1
Schistosoma mansoni nAChR subunit 0.0122 0.0356 0.0355
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0085 0.0795
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0085 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0019 0.0019
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.004 0.067
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0093 0.0093
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0017 0.0019 0.0096
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0005 0.0003
Brugia malayi hypothetical protein 0.004 0.0093 0.0092
Schistosoma mansoni nAChR subunit 0.0122 0.0356 0.0355
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0098 0.0278 0.0278
Echinococcus granulosus sex peptide receptor 0.004 0.0093 0.0093
Onchocerca volvulus 0.0066 0.0175 0.048
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0017 0.0019 0.002
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0029
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0122 0.0356 0.0355
Onchocerca volvulus 0.0196 0.0594 0.1645
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Echinococcus granulosus dna polymerase kappa 0.0019 0.0023 0.0023
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.0093 0.0093
Mycobacterium tuberculosis Probable HemK protein homolog HemK 0.0044 0.0104 0.0979
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0005 0.0078
Brugia malayi hypothetical protein 0.0043 0.0103 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.024 0.0734 0.0734
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0167 0.0166
Echinococcus granulosus glycine receptor subunit beta 0.0122 0.0356 0.0356
Onchocerca volvulus 0.0621 0.196 0.5436
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0017 0.0019 0.002
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0019 0.002
Schistosoma mansoni nAChR subunit 0.0122 0.0356 0.0355
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0191 0.0577 0.0577
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0122 0.0356 0.0355
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0002 0.0014
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0002 0.0001
Giardia lamblia PHD finger protein 15 0.0031 0.0062 0.032
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0682 0.2158 0.2158
Schistosoma mansoni cpg binding protein 0.003 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.1132 0.3605 0.3605
Trypanosoma brucei methyltransferase domain containing protein, putative 0.0044 0.0104 0.0122
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0215 0.0215
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.0093 0.0092
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.004 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0093 0.0093
Schistosoma mansoni nardilysin (M16 family) 0.0024 0.0039 0.0038
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0093 0.0093
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.0093 0.0093
Echinococcus granulosus serotonin transporter 0.1132 0.3605 0.3605
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0003 0.0039
Echinococcus multilocularis sodium and chloride dependent glycine 0.0192 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0044 0.0104 0.1771
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Schistosoma mansoni nAChR subunit 0.0122 0.0356 0.0355
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0192 0.0581 0.2688
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Echinococcus multilocularis chromobox protein 1 0.0073 0.0199 0.0199
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0151 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0192 0.0581 0.0581
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0003 0.0008
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0144 0.0144
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0024
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0087 0.0087
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0017 0.0019 0.0019
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.0278 0.0278
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0192 0.0581 0.058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0118 0.0118
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.006 0.0156 0.0155
Echinococcus granulosus g protein coupled receptor 0.004 0.0093 0.0093
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0122 0.0356 0.0355
Echinococcus granulosus allatostatin A receptor 0.004 0.0093 0.0093
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0044 0.0104 0.0104
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0093 0.0093
Brugia malayi Muscleblind-like protein 0.0151 0.045 0.045
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0144 0.0144
Trypanosoma cruzi peptidase, putative 0.0024 0.0039 0.0043
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0215 0.0215
Mycobacterium ulcerans methyltransferase 0.0044 0.0104 0.0979
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0093 0.0092
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0093 0.0093
Brugia malayi hypothetical protein 0.0056 0.0144 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.0093 0.0092
Mycobacterium ulcerans methyltransferase (methylase) 0.0044 0.0104 0.0979
Brugia malayi hypothetical protein 0.004 0.0093 0.0092
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0272 0.2662
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Onchocerca volvulus 0.004 0.0093 0.0253
Loa Loa (eye worm) ACC-1 protein 0.0122 0.0356 0.0355
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.1035 0.5645
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0079 0.0422
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0191 0.0577 0.0577
Echinococcus granulosus TRP transient receptor potential channel 0.0038 0.0085 0.0085
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0122 0.0356 0.0355
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0356 0.0355
Echinococcus multilocularis geminin 0.1359 0.4337 0.4337
Brugia malayi Carm1-pending protein 0.0682 0.2158 0.2157
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0581 0.1832 1
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.1596 0.8713
Schistosoma mansoni hypothetical protein 0.0061 0.016 0.016
Brugia malayi ORL1-like opioid receptor 0.004 0.0093 0.0092
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0017 0.0019 0.0018
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0012 0.0001 0.0001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.004 0.0093 0.0092
Schistosoma mansoni survival motor neuron protein 0.0049 0.012 0.012
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0192 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0032 0.0067 0.0066
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0054 0.0244
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0192 0.0581 0.0581
Chlamydia trachomatis glutamine binding protein 0.002 0.0027 0.0377
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Brugia malayi G-protein coupled receptor 0.004 0.0093 0.0092
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0009 0.0008
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.0278 0.0277
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0002 0.0002
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0002 0.0001
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0023 0.0024
Brugia malayi CXXC zinc finger family protein 0.0028 0.0054 0.0053
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0012 0.0001 0.0001
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.004 0.0044
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0192 0.0581 0.0581
Plasmodium vivax amine transporter, putative 0.0192 0.0581 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Schistosoma mansoni amine GPCR 0.004 0.0093 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Echinococcus multilocularis glutamate receptor 2 0.0012 0.0001 0.0001
Brugia malayi larval opioid receptor 0.004 0.0093 0.0092
Echinococcus granulosus neuropeptide receptor A26 0.004 0.0093 0.0093
Mycobacterium ulcerans methyltransferase 0.0044 0.0104 0.0979
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0044 0.0104 0.0473
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Echinococcus granulosus g protein coupled receptor 0.004 0.0093 0.0093
Echinococcus multilocularis GPCR, family 2 0.0078 0.0215 0.0215
Echinococcus granulosus protein arginine N methyltransferase 7 0.0061 0.016 0.016
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0074 0.0334
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0056 0.0144 0.0144
Echinococcus granulosus alkylated dna repair protein alkb 8 0.0044 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0169 0.0508 0.0507
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0093 0.0093
Echinococcus granulosus g protein coupled receptor 0.004 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Brugia malayi hypothetical protein 0.004 0.0093 0.0092
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.0356 0.0356
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.0093 0.0253
Schistosoma mansoni neurotransmitter gated ion channel 0.0066 0.0175 0.0174
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0005 0.002
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0507 0.1596 0.1596
Brugia malayi hypothetical protein 0.004 0.0093 0.0092
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.0093 0.0093
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0009 0.0009
Echinococcus multilocularis 0.0012 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0019 0.002
Echinococcus granulosus glycine receptor subunit beta 0.0122 0.0356 0.0356
Echinococcus multilocularis muscleblind protein 1 0.0151 0.045 0.045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 0.0024 0.0039 0.0043
Schistosoma mansoni biogenic amine receptor 0.004 0.0093 0.0092
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0005 0.0078
Mycobacterium tuberculosis Hypothetical protein 0.0044 0.0104 0.0979
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0002 0.0014
Schistosoma mansoni protein arginine n-methyltransferase 0.0682 0.2158 0.2157
Echinococcus multilocularis nardilysin 0.0024 0.0039 0.0039
Brugia malayi neuropeptide F receptor 0.004 0.0093 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0043 0.0048
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0284 0.0876 0.8673
Brugia malayi Cation transporter family protein 0.0196 0.0594 0.0594
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0325 0.1009 0.2796
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0056 0.0144 0.0144
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0044 0.0104 0.0122
Plasmodium falciparum phd finger protein, putative 0.0031 0.0062 0.1048
Echinococcus multilocularis sex peptide receptor 0.004 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0041 0.0095 0.0095
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0272 0.2662
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0054 0.0053
Brugia malayi insulin-degrading enzyme 0.0024 0.0039 0.0038
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0005 0.0003
Schistosoma mansoni hypothetical protein 0.004 0.0093 0.0092
Echinococcus granulosus nAChR subunit 0.0122 0.0356 0.0356
Brugia malayi excitatory GABA receptor EXP-1A 0.0122 0.0356 0.0355
Loa Loa (eye worm) hypothetical protein 0.0192 0.0581 0.0581
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0056 0.0144 0.0144
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.1035 0.5645
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.0093 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.0093 0.0093
Onchocerca volvulus 0.0192 0.0581 0.1609
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0192 0.0581 0.058
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0037 0.0193
Loa Loa (eye worm) zinc finger protein 0.031 0.0961 0.0961
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.004 0.0039
Schistosoma mansoni amine GPCR 0.004 0.0093 0.0092
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.0093 0.0092
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.004 0.0039
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.0093 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0581 0.1832 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0192 0.0581 0.0581
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0002 0.0001
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0061 0.016 0.019
Onchocerca volvulus Putative nachr subunit 0.0191 0.0577 0.1596
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0003 0.0008
Schistosoma mansoni hypothetical protein 0.0302 0.0936 0.0936
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.0093 0.0092
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0356 0.0355
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.0093 0.0093
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Schistosoma mansoni histamine h1 receptor 0.004 0.0093 0.0092
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0085 0.1452
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0005 0.0078
Trypanosoma brucei unspecified product 0.0013 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.0093 0.0092
Schistosoma mansoni amine GPCR 0.004 0.0093 0.0092
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0056 0.0144 0.0144
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.0553
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.003
Schistosoma mansoni transient receptor potential channel 0.0066 0.0174 0.0173
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0044 0.0104 0.0557
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0011 0.0052
Echinococcus granulosus sodium and chloride dependent glycine 0.0192 0.0581 0.0581
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0093 0.0092
Onchocerca volvulus Glucosylceramidase homolog 0.0333 0.1035 0.2867
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0192 0.0581 0.2688
Leishmania major hypothetical protein, conserved 0.0044 0.0104 0.0122
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0122 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0066 0.0175 0.0174
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus granulosus somatostatin receptor 0.004 0.0093 0.0093
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0056 0.0144 0.0144
Echinococcus granulosus snurportin 1 0.0302 0.0936 0.0936
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0162 0.0162
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0192 0.0581 0.0581
Mycobacterium ulcerans methylase 0.0044 0.0104 0.0979
Mycobacterium tuberculosis Conserved protein 0.0044 0.0104 0.0979
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.0356 0.0355
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.0093 0.0093
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0061 0.016 0.019
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0017 0.0019 0.002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0022 0.0112
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0022 0.0112
Echinococcus granulosus g-protein coupled receptor 0.004 0.0093 0.0093
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0009 0.0009
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0005 0.0003
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0005 0.0005
Toxoplasma gondii FATC domain-containing protein 0.0024 0.004 0.0179
Echinococcus granulosus sodium and chloride dependent glycine 0.0192 0.0581 0.0581
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0005 0.0003
Entamoeba histolytica hypothetical protein 0.0066 0.0175 0.0945
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.0093 0.0093
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0682 0.2158 0.2158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Schistosoma mansoni hypothetical protein 0.0031 0.0062 0.0061
Brugia malayi hypothetical protein 0.004 0.0093 0.0092
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0079 0.0422
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.003
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.004 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0581 0.1832 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.004 0.0211
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0286 0.0286
Plasmodium vivax hypothetical protein, conserved 0.0192 0.0581 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Entamoeba histolytica hypothetical protein 0.0034 0.0074 0.0393
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0062 0.0061
Loa Loa (eye worm) hypothetical protein 0.0066 0.0175 0.0174
Schistosoma mansoni opsin-like receptor 0.004 0.0093 0.0092
Mycobacterium ulcerans methyltransferase 0.0044 0.0104 0.0979
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0088 0.0087
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.0356 0.0356
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.004 0.0045
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0122 0.0356 0.0355
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0012 0.0001 0.0001
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.003 0.003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.1341 0.134
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0272 0.2662
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0037 0.0041
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.0093 0.0093
Onchocerca volvulus 0.0049 0.012 0.033
Trichomonas vaginalis chaperonin, putative 0.0024 0.004 0.0208
Plasmodium vivax importin-beta 2, putative 0.0028 0.0054 0.092
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0093 0.0092
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0074 0.1254
Trypanosoma brucei unspecified product 0.0013 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0061 0.016 0.016
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.004 0.004
Loa Loa (eye worm) LGC-31 protein 0.0122 0.0356 0.0355
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Giardia lamblia Fructose-bisphosphate aldolase 0.0581 0.1832 1
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.004 0.0208
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0196 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.258 0.8268 0.8268
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0682 0.2158 1
Brugia malayi hypothetical protein 0.004 0.0093 0.0092
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0093 0.0092
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.016 0.0867
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.0093 0.0093
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus multilocularis nAChR subunit 0.0122 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0196 0.0594 0.0594
Brugia malayi Dopamine receptor protein 2 0.004 0.0093 0.0092
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0061 0.016 0.0867
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0095 0.0511
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus granulosus peregrin 0.0031 0.0062 0.0062
Onchocerca volvulus 0.004 0.0093 0.0253
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.012 0.012
Toxoplasma gondii thioredoxin reductase 0.0038 0.0085 0.0387
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.0356 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0104 0.0557
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0097 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0022 0.0112
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.0093 0.0092
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.0093 0.0093
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0215 0.0215
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0023 0.0176
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.0553
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0162 0.0162
Echinococcus granulosus neuropeptide receptor 0.004 0.0093 0.0093
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0054 0.0062
Echinococcus multilocularis orexin receptor type 2 0.004 0.0093 0.0093
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.0093 0.0092
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0118 0.0117
Schistosoma mansoni neurotransmitter gated ion channel 0.0056 0.0144 0.0143
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0192 0.0581 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0581 0.1832 1
Leishmania major GTP-binding protein, putative 0.0021 0.003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0066 0.0175 0.0174
Schistosoma mansoni glutamate receptor NMDA 0.0065 0.0174 0.0173
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0105 0.0287
Onchocerca volvulus 0.0056 0.0144 0.0396
Leishmania major importin beta-1 subunit, putative 0.0023 0.0037 0.0041
Brugia malayi follicle stimulating hormone receptor 0.004 0.0093 0.0092
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0013 0.006
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0003 0.0039
Schistosoma mansoni acetylcholine receptor-related 0.0056 0.0144 0.0143
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0192 0.0581 0.0581
Echinococcus multilocularis serotonin receptor 0.004 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0109 0.0108
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0023 0.0176
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0581 0.1832 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0054 0.0062
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Schistosoma mansoni chromobox protein 0.0073 0.0199 0.0198
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0192 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0005 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0103 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Schistosoma mansoni hypothetical protein 0.0078 0.0215 0.0214
Schistosoma mansoni hypothetical protein 0.0049 0.012 0.012
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0017 0.0019 0.0096
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0105 0.0566
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0093 0.0093
Brugia malayi Heterochromatin protein 1 0.0073 0.0199 0.0198
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0581 0.1832 1
Brugia malayi Dopamine receptor protein 1 0.004 0.0093 0.0092
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0122 0.0356 0.0356
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0097 0.0097
Echinococcus multilocularis peregrin 0.0031 0.0062 0.0062
Echinococcus granulosus protein arginine methyltransferase 0.0044 0.0104 0.0104
Brugia malayi sulfakinin receptor protein 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0093 0.0092
Brugia malayi hypothetical protein 0.004 0.0093 0.0092
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.002 0.0027 0.0217
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0019 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0118 0.0118
Brugia malayi Cation transporter family protein 0.0122 0.0356 0.0355
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0009
Trypanosoma brucei unspecified product 0.0019 0.0023 0.0024
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0002 0.0014
Mycobacterium tuberculosis Putative methyltransferase 0.0044 0.0104 0.0979
Onchocerca volvulus 0.004 0.0093 0.0253
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0002 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0103 0.0103
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0024 0.0039 0.0038
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0061 0.016 0.0867
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0087 0.0087
Plasmodium falciparum importin beta, putative 0.0028 0.0054 0.092
Trichomonas vaginalis dullard protein, putative 0.0012 0.0003 0.0008
Brugia malayi Melatonin receptor type 1A 0.004 0.0093 0.0092
Trichomonas vaginalis dullard protein, putative 0.0012 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Onchocerca volvulus 0.0032 0.0067 0.018
Onchocerca volvulus 0.004 0.0093 0.0253
Trichomonas vaginalis glucosylceramidase, putative 0.0351 0.1092 0.596
Loa Loa (eye worm) regulatory protein 0.0044 0.0104 0.0103
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0017 0.0019 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.1596 0.8713
Mycobacterium tuberculosis Possible transferase 0.0044 0.0104 0.0979
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0074 0.0085
Brugia malayi latrophilin 2 splice variant baaae 0.0169 0.0508 0.0507
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0061 0.016 0.0867
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0053 0.0132 0.0132
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0082 0.0082
Onchocerca volvulus 0.0487 0.1531 0.4244
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0017 0.0019 0.002
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0122 0.0356 0.0356
Mycobacterium tuberculosis Possible conserved permease 0.0044 0.0104 0.0979
Echinococcus granulosus geminin 0.1359 0.4337 0.4337
Brugia malayi G protein-coupled receptor 0.004 0.0093 0.0092
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.004 0.0039
Echinococcus multilocularis nmda type glutamate receptor 0.0028 0.0052 0.0052
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.004 0.0039
Schistosoma mansoni sodium/chloride dependent transporter 0.0192 0.0581 0.058
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0085
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0093 0.0092
Onchocerca volvulus 0.004 0.0093 0.0253
Onchocerca volvulus 0.0196 0.0594 0.1645
Onchocerca volvulus 0.004 0.0093 0.0253
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0199 0.1077
Loa Loa (eye worm) hypothetical protein 0.0248 0.076 0.0759
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.0093 0.0092
Leishmania major arginine N-methyltransferase, type I 0.0061 0.016 0.019
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.0093 0.0092
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0009 0.0008
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0017 0.0019 0.002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.0093 0.0093
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0044 0.0104 0.0103
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0056 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0191 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0175 0.0174
Echinococcus multilocularis fmrfamide receptor 0.004 0.0093 0.0093
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0162 0.0162
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0241 0.1785
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0192 0.0581 0.0581
Mycobacterium ulcerans methyltransferase 0.0044 0.0104 0.0979
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0019 0.0019
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0005 0.0005
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0003 0.0008
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.0093 0.0092
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus granulosus G protein coupled receptor 139 0.004 0.0093 0.0093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0093 0.0093
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0192 0.0581 0.058
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0012 0.0003 0.0008
Entamoeba histolytica hypothetical protein 0.0024 0.004 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0104 0.0557
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0192 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0191 0.0577 0.0576
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0581 0.1832 1
Echinococcus granulosus chromobox protein 1 0.0073 0.0199 0.0199
Mycobacterium ulcerans methyltransferase 0.0044 0.0104 0.0979
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0192 0.0581 0.058
Echinococcus multilocularis transcription factor btf3 0.0034 0.0074 0.0074
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.0356 0.0356
Leishmania major DNA polymerase eta, putative 0.0019 0.0023 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0005 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0581 0.1832 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0056 0.0144 0.0144
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0005 0.0005
Brugia malayi GnHR receptor homolog 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Plasmodium vivax glutathione reductase, putative 0.0038 0.0085 0.1452
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0062 0.0062
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0005 0.0017
Brugia malayi Thioredoxin reductase 0.0038 0.0085 0.0085
Onchocerca volvulus 0.0056 0.0144 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0074 0.0393
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0093 0.0093
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.0093 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.0333 0.1035 0.5645
Schistosoma mansoni biogenic amine receptor 0.004 0.0093 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0093 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0074 0.0393
Echinococcus multilocularis snurportin 1 0.0302 0.0936 0.0936
Echinococcus multilocularis dna polymerase eta 0.0019 0.0023 0.0023
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0093 0.0092
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.0356 0.0356
Toxoplasma gondii target of rapamycin (TOR), putative 0.0017 0.0019 0.0082
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0093 0.0093
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0007 0.0006
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0012 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0004 0.0002
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0012 0.0001 0.0001
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0038 0.0085 0.0085
Onchocerca volvulus 0.1132 0.3605 1
Echinococcus multilocularis somatostatin receptor 0.004 0.0093 0.0093
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0093 0.0093
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0066 0.0175 0.0174
Toxoplasma gondii hypothetical protein 0.0044 0.0104 0.0473
Schistosoma mansoni opsin-like receptor 0.004 0.0093 0.0092
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.002 0.0027 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0066 0.0175 0.0174
Trypanosoma cruzi phytoene synthase, putative 0.0325 0.1009 0.1217
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.01 0.01
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.002 0.0027 0.006
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0199 0.1077
Schistosoma mansoni nAChR subunit 0.0056 0.0144 0.0143
Brugia malayi hypothetical protein 0.0056 0.0144 0.0144
Onchocerca volvulus 0.0012 0.0002 0.000000022936
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.004 0.0044
Onchocerca volvulus 0.0122 0.0356 0.0983
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0284 0.0876 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0144 0.0144
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0192 0.0581 0.2688
Treponema pallidum fructose-bisphosphate aldolase 0.0581 0.1832 0.5074
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.0093 0.0093
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0005 0.5
Echinococcus multilocularis nardilysin 0.0024 0.0039 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0581 0.1832 1
Loa Loa (eye worm) hypothetical protein 0.0192 0.0581 0.0581
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0033
Echinococcus granulosus survival motor neuron protein 1 0.024 0.0734 0.0734
Loa Loa (eye worm) acetylcholine receptor protein 0.0056 0.0144 0.0144
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0109 0.0108
Schistosoma mansoni neuropeptide receptor 0.004 0.0093 0.0092
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.0093 0.0092
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0104 0.0979
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus multilocularis g protein coupled receptor 0.004 0.0093 0.0093
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0192 0.0581 0.0581
Brugia malayi RE15519p 0.004 0.0093 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0093 0.0092
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.0093 0.0093
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0093 0.0093
Entamoeba histolytica Ran family GTPase 0.0021 0.003 0.0156
Schistosoma mansoni acetylcholine receptor subunit beta 0.0056 0.0144 0.0143
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1132 0.3605 0.3605
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0013 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0356 0.0355
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0029 0.0032
Echinococcus multilocularis glycine receptor subunit beta 0.0122 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0122 0.0356 0.0356
Schistosoma mansoni sodium/chloride dependent transporter 0.1132 0.3605 0.3604
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0022 0.0112
Plasmodium falciparum amino acid transporter, putative 0.0192 0.0581 1
Echinococcus granulosus fmrfamide receptor 0.004 0.0093 0.0093
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0162 0.0745
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.1596 0.8713
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0199 0.0198
Echinococcus granulosus zinc finger transcription factor gli2 0.031 0.0961 0.0961
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0024 0.0039 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0093 0.0092
Schistosoma mansoni ran 0.0021 0.003 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0093 0.0092
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0241 0.2352
Echinococcus multilocularis Squalene phytoene synthase 0.0325 0.1009 0.1009
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Echinococcus granulosus orexin receptor type 2 0.004 0.0093 0.0093
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0286 0.0286
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0061 0.016 0.019
Brugia malayi SET domain containing protein 0.0015 0.0011 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0024
Onchocerca volvulus 0.0192 0.0581 0.1609
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0085 0.0085
Schistosoma mansoni nAChR subunit 0.0122 0.0356 0.0355
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0037 0.0193
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0163 0.0162
Trypanosoma brucei peptidase, putative 0.0024 0.0039 0.0043
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0196 0.0594 0.0594
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0044 0.0104 0.0557
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0023 0.0023
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0061 0.016 0.019
Echinococcus multilocularis insulin degrading enzyme 0.0024 0.0039 0.0039
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0241 0.2352
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0095 0.0511
Onchocerca volvulus 0.0122 0.0356 0.0983
Loa Loa (eye worm) hypothetical protein 0.0028 0.0054 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0093 0.0092
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0061 0.016 0.019
Brugia malayi hypothetical protein 0.0025 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0122 0.0356 0.0355
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.003 0.0132
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0192 0.0581 0.058
Onchocerca volvulus 0.0028 0.0054 0.0145
Loa Loa (eye worm) norepinephrine transporter 0.1132 0.3605 0.3605
Brugia malayi jmjC domain containing protein 0.0039 0.0088 0.0087
Entamoeba histolytica hypothetical protein 0.0043 0.0103 0.0553
Brugia malayi Protein cec-1. 0.0012 0.0002 0.0001
Brugia malayi Zinc finger, C2H2 type family protein 0.031 0.0961 0.0961
Onchocerca volvulus 0.004 0.0093 0.0253
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0122 0.0356 0.0356
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0024
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.0093 0.0092
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0005 0.0003
Brugia malayi RNA, U transporter 1 0.0081 0.0222 0.0222
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0012 0.0003 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0005 0.0003
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0007 0.0006
Schistosoma mansoni neuropeptide receptor 0.004 0.0093 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0507 0.1596 0.8713
Schistosoma mansoni protein arginine n-methyltransferase 0.0044 0.0104 0.0103
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0192 0.0581 0.058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0175 0.0174
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.0093 0.0092
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0122 0.0356 0.0355
Onchocerca volvulus 0.0074 0.0201 0.0553
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0174 0.0174
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0023 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0093 0.0093
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0066 0.0175 0.0174
Loa Loa (eye worm) hypothetical protein 0.0062 0.0162 0.0162
Echinococcus granulosus Chromobox protein 3 0.0012 0.0002 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0019 0.0019
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0174 0.0174
Trypanosoma cruzi C-8 sterol isomerase, putative 0.258 0.8268 1
Schistosoma mansoni chromobox protein 0.0073 0.0199 0.0198
Echinococcus multilocularis chromobox protein 1 0.0073 0.0199 0.0199
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.004 0.0208
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0062 0.0062
Loa Loa (eye worm) serotonin transporter b 0.1132 0.3605 0.3605
Echinococcus multilocularis neuropeptide s receptor 0.004 0.0093 0.0093
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0093 0.0093
Plasmodium falciparum thioredoxin reductase 0.0013 0.0005 0.0078
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0348 0.0348
Brugia malayi Pre-SET motif family protein 0.0428 0.1341 0.134
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0093 0.0093
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0356 0.0355
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.0356 0.0355
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.003 0.003
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0044 0.0104 0.0103
Echinococcus granulosus jumonji domain containing protein 0.0043 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Schistosoma mansoni nAChR subunit 0.0122 0.0356 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0057 0.03
Trichomonas vaginalis glucosylceramidase, putative 0.0351 0.1092 0.596
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0003 0.0003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0005 0.0005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0356 0.0355
Onchocerca volvulus 0.004 0.0093 0.0253
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.3118 1 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0023 0.0176
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0103 0.0103
Echinococcus granulosus serine protein kinase ATM 0.0024 0.004 0.004
Schistosoma mansoni chromobox protein 0.0012 0.0002 0.0001
Mycobacterium ulcerans methyltransferase/methylase 0.0044 0.0104 0.0979
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0093 0.0092
Echinococcus granulosus methyltransferase protein 5 0.0061 0.016 0.016
Echinococcus granulosus Squalene phytoene synthase 0.0325 0.1009 0.1009
Schistosoma mansoni transient receptor potential channel 0.0098 0.0278 0.0277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0005 0.0003
Mycobacterium ulcerans methyltransferase 0.0044 0.0104 0.0979
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0002 0.0001
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0023 0.0024
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0012 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Brugia malayi PHD-finger family protein 0.0031 0.0062 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0019 0.0096
Trypanosoma brucei squalene synthase, putative 0.1043 0.3319 0.4012
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0122 0.0356 0.0355
Mycobacterium tuberculosis Putative transferase 0.0044 0.0104 0.0979
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0191 0.0577 0.0577
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.014 0.0413 0.0413
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0009 0.0009
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0017 0.0019 0.0019
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.0278 0.0278
Onchocerca volvulus 0.004 0.0093 0.0253
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0325 0.1009 1
Plasmodium falciparum phosphoethanolamine N-methyltransferase 0.0044 0.0104 0.1771
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0093 0.0093
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0023 0.0117
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0023 0.0117
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0074 0.0085
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Giardia lamblia GTOR 0.0017 0.0019 0.0089
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.0093 0.0092
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.076 0.0759
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0001
Onchocerca volvulus 0.004 0.0093 0.0253
Loa Loa (eye worm) hypothetical protein 0.004 0.0093 0.0092
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0215 0.0215
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0122 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0056 0.0144 0.0144
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0044 0.0104 0.0122
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0122 0.0356 0.0355
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0191 0.0577 0.0577

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4611 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 1 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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