Detailed information for compound 1533001

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 657.637 | Formula: C32H34F3N5O7
  • H donors: 4 H acceptors: 4 LogP: 3.88 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H](N1C[C@H](C)[C@@H](CN(C(=O)Nc2ccc3c(c2)OCO3)C)Oc2c(C1=O)cc(cc2)NC(=O)Nc1ccc(cc1)C(F)(F)F)C
  • InChi: 1S/C32H34F3N5O7/c1-18-14-40(19(2)16-41)29(42)24-12-22(37-30(43)36-21-6-4-20(5-7-21)32(33,34)35)8-10-25(24)47-28(18)15-39(3)31(44)38-23-9-11-26-27(13-23)46-17-45-26/h4-13,18-19,28,41H,14-17H2,1-3H3,(H,38,44)(H2,36,37,43)/t18-,19+,28+/m0/s1
  • InChiKey: KLPMWOVSXYVUBV-DORSKGMSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi histone deacetylase 11 0.0418 0.2407 0.2407
Brugia malayi hypothetical protein 0.005 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0084 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0162 0.0799 0.0799
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0079 0.0076
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0145 0.0193
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0388 0.2215 0.2195
Onchocerca volvulus 0.0048 0.0079 0.0165
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0482 0.0714
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0271 0.1484 0.256
Trypanosoma brucei histone deacetylase 1 0.0619 0.3665 0.6386
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0619 0.3665 0.6359
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.005 0.0097 0.007
Echinococcus multilocularis histone deacetylase 6 0.0406 0.2329 0.4045
Echinococcus multilocularis calpain 0.0058 0.0145 0.0209
Toxoplasma gondii subtilisin SUB10 0.005 0.0097 0.0201
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0205 0.0314
Plasmodium falciparum subtilisin-like protease 3 0.005 0.0097 0.0103
Onchocerca volvulus 0.005 0.0097 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0308 0.048
Trypanosoma cruzi oligopeptidase b 0.0319 0.178 0.307
Schistosoma mansoni furin-1 (S08 family) 0.005 0.0097 0.007
Brugia malayi Histone deacetylase 1 0.0619 0.3665 0.3665
Onchocerca volvulus 0.0039 0.0026 0.0055
Toxoplasma gondii aspartyl protease 0.0099 0.0405 0.0843
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0084 0.0308 0.048
Plasmodium falciparum histone deacetylase 2 0.0406 0.2329 0.6292
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.005 0.0097 0.0123
Plasmodium vivax calpain, putative 0.0058 0.0145 0.0184
Schistosoma mansoni site-1 peptidase (S08 family) 0.005 0.0097 0.007
Plasmodium vivax subtilisin-like serine protease, putative 0.005 0.0097 0.0048
Loa Loa (eye worm) hypothetical protein 0.025 0.1348 0.1348
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0271 0.1484 0.1461
Loa Loa (eye worm) histone deacetylase 1 0.0619 0.3665 0.3665
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0039 0.0039
Plasmodium vivax aspartyl proteinase, putative 0.0183 0.093 0.2372
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0084 0.0308 0.0283
Plasmodium vivax plasmepsin IV, putative 0.0183 0.093 0.2372
Brugia malayi Hemopexin family protein 0.0315 0.1754 0.1754
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0145 0.0193
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0145 0.0193
Brugia malayi Kringle domain containing protein 0.0076 0.0261 0.0261
Toxoplasma gondii kringle domain-containing protein 0.0076 0.0261 0.0542
Onchocerca volvulus Matrilysin homolog 0.0492 0.2868 0.5963
Brugia malayi Inositol-1 0.0074 0.0243 0.0243
Brugia malayi Matrixin family protein 0.0222 0.1173 0.1173
Onchocerca volvulus Cathepsin L homolog 0.0048 0.0079 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0102 0.0422 0.0608
Loa Loa (eye worm) calpain family protein 1 0.0113 0.0492 0.0492
Toxoplasma gondii subtilisin SUB5 0.005 0.0097 0.0201
Schistosoma mansoni chromatin regulatory protein sir2 0.0946 0.5718 0.5707
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0639 0.1076
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0243 0.0365
Leishmania major cathepsin L-like protease 0.0048 0.0079 0.0076
Brugia malayi transcriptional regulator, Sir2 family protein 0.0946 0.5718 0.5718
Brugia malayi Pepsin A precursor 0.0099 0.0405 0.0405
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0639 0.1076
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0619 0.3665 0.6359
Loa Loa (eye worm) prolyl oligopeptidase 0.0084 0.0308 0.0308
Trypanosoma brucei DNA repair protein, putative 0.0059 0.0149 0.02
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Loa Loa (eye worm) hypothetical protein 0.0379 0.216 0.216
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0084 0.0308 0.0641
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0094 0.0102
Leishmania major cathepsin L-like protease 0.0048 0.0079 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0096 0.0382 0.0609
Onchocerca volvulus 0.0126 0.057 0.1185
Trypanosoma cruzi cysteine peptidase, putative 0.0096 0.0382 0.0609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0096 0.0382 0.0609
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0473 0.0448
Echinococcus multilocularis histone deacetylase 8 0.025 0.1348 0.2322
Brugia malayi WGR domain containing protein 0.045 0.2603 0.2603
Echinococcus multilocularis Furin 1 0.005 0.0097 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0096 0.0382 0.0609
Mycobacterium leprae Probable lipase LipE 0.0112 0.0482 0.229
Schistosoma mansoni hypothetical protein 0.011 0.0473 0.0448
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0151 0.0125
Loa Loa (eye worm) matrixin family protein 0.0536 0.3146 0.3146
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.0482 0.0482
Brugia malayi Matrixin family protein 0.0222 0.1173 0.1173
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0686 0.0686
Brugia malayi Cathepsin L-like precursor 0.0048 0.0079 0.0079
Brugia malayi prolyl oligopeptidase family protein 0.0084 0.0308 0.0308
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0048 0.0079 0.0093
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0243 0.0291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0096 0.0382 0.0609
Giardia lamblia Hypothetical protein 0.0095 0.0379 0.0131
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0243 0.0365
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0467 0.2713 0.5642
Brugia malayi Eukaryotic aspartyl protease family protein 0.0099 0.0405 0.0405
Plasmodium falciparum cysteine repeat modular protein 1 0.0076 0.0261 0.0558
Echinococcus granulosus histone deacetylase 3 0.0619 0.3665 0.6392
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0026
Giardia lamblia Transcriptional regulator, Sir2 family 0.0195 0.1005 0.1287
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.005 0.0097 0.0107
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0145 0.0193
Echinococcus granulosus prolyl endopeptidase 0.0801 0.4809 0.8403
Schistosoma mansoni cathepsin D (A01 family) 0.1003 0.6074 0.6064
Trypanosoma brucei histone deacetylase 2 0.025 0.1348 0.2309
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0222 0.1173 0.1149
Echinococcus granulosus calpain A 0.0165 0.0813 0.1383
Brugia malayi transcriptional regulator, Sir2 family protein 0.0195 0.1005 0.1005
Leishmania major histone deacetylase, putative 0.0619 0.3665 0.6386
Echinococcus multilocularis prolyl endopeptidase 0.0801 0.4809 0.8403
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0195 0.1005 0.1641
Schistosoma mansoni calpain-7 (C02 family) 0.0058 0.0145 0.0119
Mycobacterium leprae PROBABLE HYDROLASE 0.027 0.1476 0.8192
Brugia malayi MH2 domain containing protein 0.0144 0.0686 0.0686
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0145 0.0193
Echinococcus granulosus cathepsin L cysteine proteinase 0.0048 0.0079 0.0093
Echinococcus granulosus histone deacetylase 6 0.0412 0.2366 0.4111
Plasmodium falciparum plasmepsin I 0.0183 0.093 0.2414
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0151 0.0218
Loa Loa (eye worm) hypothetical protein 0.0084 0.0308 0.0308
Schistosoma mansoni hypothetical protein 0.0095 0.0379 0.0354
Loa Loa (eye worm) hypothetical protein 0.0113 0.0492 0.0492
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0388 0.2215 0.3846
Echinococcus multilocularis adam 17 protease 0.018 0.0913 0.1558
Toxoplasma gondii hypothetical protein 0.0084 0.0308 0.0641
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0625 0.3699 0.6268
Onchocerca volvulus 0.0039 0.0026 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Schistosoma mansoni caspase-7 (C14 family) 0.0126 0.057 0.0545
Echinococcus multilocularis tissue type plasminogen activator 0.0076 0.0261 0.0412
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.061 0.3607 0.6291
Toxoplasma gondii subtilisin SUB4 0.005 0.0097 0.0201
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0099 0.0405 0.0843
Echinococcus granulosus Furin 1 0.005 0.0097 0.0123
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0195 0.1005 0.1694
Onchocerca volvulus 0.0039 0.0026 0.0055
Leishmania major subtilisin-like serine peptidase 0.005 0.0097 0.0107
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0145 0.0193
Brugia malayi hypothetical protein 0.011 0.0473 0.0473
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0247 0.1331 0.2293
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0151 0.0708
Schistosoma mansoni inositol monophosphatase 0.0074 0.0243 0.0218
Loa Loa (eye worm) hypothetical protein 0.0625 0.3699 0.3699
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1268 0.2182
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0319 0.178 0.307
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0159 0.0159
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.027 0.1476 0.1476
Echinococcus granulosus histone deacetylase 7 0.0406 0.2329 0.4045
Onchocerca volvulus 0.0112 0.0482 0.1003
Schistosoma mansoni hypothetical protein 0.0076 0.0261 0.0235
Trypanosoma brucei histone deacetylase, putative 0.0406 0.2329 0.4035
Schistosoma mansoni ets-related 0.0213 0.112 0.1096
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0388 0.2215 0.2215
Echinococcus granulosus membrane bound transcription factor site 1 0.005 0.0097 0.0123
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0085 0.0316 0.0508
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0195 0.1005 0.1705
Onchocerca volvulus DNA ligase 3 homolog 0.0059 0.0149 0.0311
Onchocerca volvulus Histone deacetylase 10 homolog 0.025 0.1348 0.2803
Onchocerca volvulus Cathepsin L homolog 0.0048 0.0079 0.0165
Plasmodium vivax histone deacetylase, putative 0.0418 0.2407 0.6489
Plasmodium falciparum peptidase, putative 0.0084 0.0308 0.069
Trypanosoma cruzi histone deacetylase, putative 0.0406 0.2329 0.4035
Plasmodium vivax NAD-dependent deacetylase, putative 0.0195 0.1005 0.258
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.0482 0.0785
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.005 0.0097 0.007
Mycobacterium tuberculosis Conserved protein 0.0112 0.0482 0.1001
Echinococcus multilocularis 0.005 0.0097 0.0123
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0084 0.0308 0.0495
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0099 0.0405 0.038
Echinococcus granulosus histone deacetylase 8 0.025 0.1348 0.2322
Brugia malayi cathepsin B-like cysteine proteinase 0.0295 0.1632 0.1632
Schistosoma mansoni poly [ADP-ribose] polymerase 0.045 0.2603 0.2583
Echinococcus granulosus tissue type plasminogen activator 0.0076 0.0261 0.0412
Brugia malayi proprotein convertase 2 0.005 0.0097 0.0097
Schistosoma mansoni cathepsin F (C01 family) 0.0048 0.0079 0.0053
Brugia malayi Cathepsin L-like precursor 0.0048 0.0079 0.0079
Schistosoma mansoni chromatin regulatory protein sir2 0.0946 0.5718 0.5707
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0084 0.0308 0.048
Brugia malayi Trypsin-like protease protein 5 0.0039 0.0026 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0096 0.0382 0.0609
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0482 0.0714
Loa Loa (eye worm) hypothetical protein 0.0112 0.0482 0.0482
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0102 0.0422 0.0397
Echinococcus multilocularis cathepsin b 0.0295 0.1632 0.2821
Onchocerca volvulus 0.0291 0.1604 0.3336
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0159 0.0159
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0094 0.0102
Loa Loa (eye worm) hypothetical protein 0.0137 0.0637 0.0637
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.005 0.0097 0.0107
Echinococcus multilocularis cysteine protease 0.0048 0.0079 0.0093
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0103 0.0428 0.0706
Loa Loa (eye worm) hypothetical protein 0.0059 0.0149 0.0149
Onchocerca volvulus 0.0216 0.1137 0.2365
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0085 0.0316 0.029
Leishmania major prefoldin subunit, putative 0.0095 0.0379 0.0604
Onchocerca volvulus 0.0096 0.0383 0.0796
Echinococcus multilocularis acylamino acid releasing enzyme 0.0084 0.0308 0.0495
Onchocerca volvulus 0.0076 0.0261 0.0542
Leishmania major hypothetical protein, conserved 0.0044 0.006 0.0042
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0295 0.1632 0.161
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0247 0.1331 0.1308
Brugia malayi Fli-1 protein 0.0213 0.112 0.112
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0195 0.1005 0.1719
Loa Loa (eye worm) hypothetical protein 0.0126 0.057 0.057
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0151 0.0125
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0094 0.004
Onchocerca volvulus Matrix metalloproteinase homolog 0.0492 0.2868 0.5963
Loa Loa (eye worm) hypothetical protein 0.005 0.0097 0.0097
Echinococcus granulosus prefoldin subunit 6 0.0095 0.0379 0.062
Echinococcus multilocularis chromatin regulatory protein sir2 0.0946 0.5718 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.0482 0.1001
Schistosoma mansoni hypothetical protein 0.0315 0.1754 0.1732
Onchocerca volvulus 0.0039 0.0026 0.0055
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0099 0.0405 0.038
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.1604 0.1604
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0096 0.0382 0.0609
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0619 0.3665 0.6359
Onchocerca volvulus Deterin homolog 0.0388 0.2215 0.4607
Schistosoma mansoni hypothetical protein 0.0205 0.1065 0.1041
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0482 0.0714
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0205 0.0314
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0094 0.0094
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0183 0.093 0.1588
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0308 0.0639
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0026
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0319 0.178 1
Plasmodium falciparum plasmepsin VII 0.0099 0.0405 0.0958
Echinococcus multilocularis geminin 0.0205 0.1065 0.1824
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0639 0.1076
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.0079 0.0079
Trypanosoma cruzi histone deacetylase, putative 0.025 0.1348 0.2309
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0271 0.1484 0.256
Leishmania major cathepsin L-like protease 0.0096 0.0382 0.0609
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0113 0.0491 0.0817
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0099 0.0405 0.0405
Mycobacterium ulcerans NAD-dependent deacetylase 0.0195 0.1005 0.5577
Loa Loa (eye worm) hypothetical protein 0.0099 0.0405 0.0405
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0159 0.0159
Plasmodium vivax prefoldin subunit 6, putative 0.0095 0.0379 0.0836
Entamoeba histolytica hypothetical protein 0.011 0.0473 0.0765
Schistosoma mansoni chromatin regulatory protein sir2 0.0195 0.1005 0.0981
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0102 0.0422 0.068
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0048 0.0079 0.0093
Echinococcus granulosus histone deacetylase 6 0.0406 0.2329 0.4045
Brugia malayi Ets-domain containing protein 0.007 0.0222 0.0222
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0717 0.4282 1
Loa Loa (eye worm) hypothetical protein 0.0429 0.2476 0.2476
Loa Loa (eye worm) hypothetical protein 0.0222 0.1173 0.1173
Echinococcus granulosus histone deacetylase 0.0406 0.2329 0.4045
Toxoplasma gondii subtilisin SUB8 0.005 0.0097 0.0201
Echinococcus multilocularis histone deacetylase 1 0.0619 0.3665 0.6392
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.005 0.0097 0.007
Onchocerca volvulus 0.0048 0.0079 0.0165
Schistosoma mansoni calpain-7 (C02 family) 0.0058 0.0145 0.0119
Entamoeba histolytica prefoldin subunit 6, putative 0.0095 0.0379 0.06
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0195 0.1005 0.1705
Trichomonas vaginalis histone deacetylase, putative 0.0619 0.3665 0.6359
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0801 0.4809 0.84
Mycobacterium ulcerans beta-lactamase 0.0112 0.0482 0.2598
Trypanosoma brucei histone deacetylase 3 0.0406 0.2329 0.4035
Trypanosoma brucei SIR2-like protein 4, putative 0.0195 0.1005 0.1705
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0243 0.0506
Trypanosoma cruzi cysteine peptidase, putative 0.0096 0.0382 0.0609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0639 0.0614
Trichomonas vaginalis histone deacetylase, putative 0.0619 0.3665 0.6359
Loa Loa (eye worm) hypothetical protein 0.005 0.0094 0.0094
Brugia malayi beta-lactamase 0.0112 0.0482 0.0482
Entamoeba histolytica hypothetical protein 0.011 0.0473 0.0765
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0177 0.0893 0.0893
Leishmania major histone deacetylase, putative 0.0619 0.3665 0.6386
Echinococcus multilocularis prefoldin subunit 6 0.0095 0.0379 0.062
Plasmodium falciparum plasmepsin VI 0.0183 0.093 0.2414
Plasmodium falciparum plasmepsin IV 0.0183 0.093 0.2414
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.1137 0.1114
Loa Loa (eye worm) trypsin family protein 0.0039 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0097 0.0031
Brugia malayi hypothetical protein 0.0099 0.0405 0.0405
Echinococcus multilocularis hypothetical protein 0.0058 0.0145 0.0209
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.045 0.2603 0.4488
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.0482 0.0801
Leishmania major cathepsin L-like protease 0.0048 0.0079 0.0076
Loa Loa (eye worm) calpain 5 0.0041 0.0036 0.0036
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0145 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0097 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0686 0.0686
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0482 0.0457
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.0482 0.1001
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0145 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0482 0.1123
Echinococcus granulosus neuroendocrine convertase 2 0.005 0.0097 0.0123
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0145 0.0193
Toxoplasma gondii aspartyl protease ASP1 0.0183 0.093 0.1934
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0099 0.0405 0.038
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0243 0.0365
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0364 0.2064 0.2064
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0059 0.0149 0.02
Trypanosoma brucei prolyl oligopeptidase, putative 0.0319 0.178 0.307
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0048 0.0079 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.006 0.0042
Toxoplasma gondii prolyl endopeptidase 0.0801 0.4809 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.005 0.0097 0.0123
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.045 0.2603 0.4526
Schistosoma mansoni histone deacetylase hda2 0.025 0.1348 0.1325
Echinococcus multilocularis histone deacetylase 7 0.0406 0.2329 0.4045
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.005 0.0097 0.0097
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.005 0.0097 0.0088
Treponema pallidum mcbG protein 0.0044 0.006 0.5
Giardia lamblia Cathepsin B precursor 0.0102 0.0422 0.021
Echinococcus multilocularis apoptotic protease activating factor 1 0.0126 0.057 0.0955
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.005 0.0097 0.04
Onchocerca volvulus 0.0099 0.0405 0.0843
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.027 0.1476 0.3355
Schistosoma mansoni hypothetical protein 0.0126 0.057 0.0545
Schistosoma mansoni P2X receptor subunit 0.0068 0.0205 0.0179
Schistosoma mansoni P2X receptor subunit 0.0068 0.0205 0.0179
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0195 0.1005 0.1641
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0473 0.0785
Trypanosoma cruzi histone deacetylase, putative 0.0406 0.2329 0.4035
Echinococcus granulosus cathepsin b 0.0295 0.1632 0.2821
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0222 0.0222
Echinococcus granulosus apoptotic protease activating factor 1 0.0126 0.057 0.0955
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0801 0.4809 0.4795
Brugia malayi hypothetical protein 0.0099 0.0405 0.0405
Trypanosoma brucei prefoldin subunit, putative 0.0095 0.0379 0.0604
Toxoplasma gondii subtilisin SUB6 0.005 0.0097 0.0201
Loa Loa (eye worm) hypothetical protein 0.005 0.0097 0.0097
Leishmania major oligopeptidase b 0.0319 0.178 0.307
Mycobacterium tuberculosis Probable peptidase 0.0319 0.178 0.4076
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.005 0.0097 0.0107
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0195 0.0321
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0164 0.0812 0.0788
Loa Loa (eye worm) calpain 0.0058 0.0145 0.0145
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0639 0.0639
Trypanosoma brucei poly(adp-ribose) polymerase 0.0247 0.1331 0.228
Onchocerca volvulus 0.0099 0.0405 0.0843
Schistosoma mansoni hypothetical protein 0.0205 0.1065 0.1041
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0084 0.0308 0.0476
Schistosoma mansoni gabp alpha 0.007 0.0222 0.0196
Echinococcus multilocularis histone deacetylase 6 0.0412 0.2366 0.4111
Toxoplasma gondii histone deacetylase HDAC5 0.025 0.1348 0.2803
Echinococcus multilocularis calpain 5 0.0058 0.0145 0.0209
Leishmania major cathepsin L-like protease 0.0096 0.0382 0.0609
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0247 0.1331 0.228
Schistosoma mansoni hypothetical protein 0.0388 0.2215 0.2195
Leishmania major hypothetical protein, conserved 0.0059 0.0149 0.02
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0195 0.1005 0.1719
Brugia malayi neuroendocrine convertase 1 precursor 0.005 0.0097 0.0097
Leishmania major silent information regulator 2, putative 0.0946 0.5718 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0158 0.0158
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0079 0.0076
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0625 0.3699 0.6453
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0113 0.0491 0.0817
Echinococcus multilocularis cathepsin L cysteine protease 0.0048 0.0079 0.0093
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.005 0.0097 0.0088
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0151 0.0218
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0243 0.0381
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0164 0.0812 0.138
Loa Loa (eye worm) hypothetical protein 0.0342 0.1929 0.1929
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Loa Loa (eye worm) hypothetical protein 0.0295 0.1632 0.1632
Toxoplasma gondii histone deacetylase SIR2 0.0195 0.1005 0.2089
Brugia malayi Cell death protein 3 precursor 0.0126 0.057 0.057
Schistosoma mansoni calpain C (C02 family) 0.0058 0.0145 0.0119
Brugia malayi beta-lactamase family protein 0.0112 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0156 0.0761 0.0761
Leishmania major cathepsin L-like protease 0.0048 0.0079 0.0076
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0205 0.0314
Onchocerca volvulus 0.0222 0.1173 0.2439
Mycobacterium ulcerans lipase LipD 0.0112 0.0482 0.2598
Toxoplasma gondii subtilisin SUB9 0.005 0.0097 0.0201
Onchocerca volvulus 0.0177 0.0892 0.1854
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0482 0.0785
Brugia malayi aspartic protease BmAsp-1, identical 0.0099 0.0405 0.0405
Loa Loa (eye worm) prolyl oligopeptidase 0.0084 0.0308 0.0308
Leishmania major hypothetical protein, conserved 0.0076 0.0261 0.0396
Entamoeba histolytica hypothetical protein 0.011 0.0473 0.0765
Brugia malayi aspartic protease BmAsp-2, identical 0.0099 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0026
Giardia lamblia Hypothetical protein 0.0946 0.5718 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0151 0.0708
Brugia malayi Histone deacetylase family protein 0.0406 0.2329 0.2329
Echinococcus multilocularis caspase 2 0.0126 0.057 0.0955
Echinococcus multilocularis calpain family protein 1, d 0.0113 0.0492 0.0818
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0096 0.0382 0.0609
Echinococcus multilocularis cathepsin L cysteine protease 0.0048 0.0079 0.0093
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0145 0.0193
Leishmania major C-8 sterol isomerase-like protein 0.0364 0.2064 0.3569
Giardia lamblia Sirtuin type 2 0.0195 0.1005 0.1287
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0243 0.0381
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0096 0.0382 0.0609
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0482 0.0785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0096 0.0382 0.0609
Loa Loa (eye worm) calpain family protein 1 0.0154 0.0747 0.0747
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0625 0.3699 0.642
Loa Loa (eye worm) TK/ROR protein kinase 0.0076 0.0261 0.0261
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0388 0.2215 0.3846
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0079 0.0079
Trypanosoma brucei C-8 sterol isomerase, putative 0.0364 0.2064 0.3569
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0195 0.1005 0.1641
Loa Loa (eye worm) histone deacetylase 3 0.0619 0.3665 0.3665
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0388 0.2215 0.2215
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0151 0.0216
Leishmania major hypothetical protein, conserved 0.0044 0.006 0.0042
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0026
Loa Loa (eye worm) aspartyl protease 6 0.0099 0.0405 0.0405
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1268 0.2182
Trypanosoma brucei subtilisin peptidase 0.005 0.0097 0.0107
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.0482 0.1001
Brugia malayi histone deacetylase 1 (HD1) 0.0619 0.3665 0.3665
Schistosoma mansoni Mername-AA248 (C02 family) 0.0058 0.0145 0.0119
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0195 0.1005 0.1719
Toxoplasma gondii histone deacetylase SIR2-like 0.0195 0.1005 0.2089
Trypanosoma cruzi subtilisin peptidase 0.005 0.0097 0.0107
Leishmania major sir2-family protein-like protein 0.0195 0.1005 0.1705
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0084 0.0308 0.0283
Onchocerca volvulus 0.0048 0.0079 0.0165
Toxoplasma gondii PAN domain-containing protein 0.0321 0.1793 0.3728
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0145 0.0193
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.005 0.0097 0.0088
Schistosoma mansoni histone deacetylase 0.0619 0.3665 0.3648
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0096 0.0382 0.0609
Trypanosoma cruzi histone deacetylase 1, putative 0.0619 0.3665 0.6386
Onchocerca volvulus 0.0388 0.2215 0.4607
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0099 0.0405 0.038
Echinococcus granulosus poly (ADP ribose) polymerase 0.007 0.0219 0.0339
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Echinococcus granulosus adam 17 protease 0.0198 0.1026 0.1756
Entamoeba histolytica hypothetical protein, conserved 0.0195 0.1005 0.1694
Brugia malayi Trypsin family protein 0.0039 0.0026 0.0026
Onchocerca volvulus Prolyl endopeptidase homolog 0.0801 0.4809 1
Onchocerca volvulus 0.0048 0.0079 0.0165
Toxoplasma gondii cathepsin CPL 0.0048 0.0079 0.0165
Schistosoma mansoni chromatin regulatory protein sir2 0.0195 0.1005 0.0981
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0625 0.3699 0.6453
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0946 0.5718 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0084 0.0308 0.0283
Loa Loa (eye worm) hypothetical protein 0.0096 0.0383 0.0383
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0097 0.0031
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0195 0.1005 0.1719
Toxoplasma gondii prefoldin subunit 6, putative 0.0095 0.0379 0.0789
Loa Loa (eye worm) ctsf protein 0.0048 0.0079 0.0079
Trypanosoma brucei histone deacetylase 4 0.0406 0.2329 0.4035
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0946 0.5718 1
Echinococcus granulosus caspase 2 0.0126 0.057 0.0955
Loa Loa (eye worm) hypothetical protein 0.0112 0.0482 0.0482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0639 0.0614
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0151 0.0313
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0183 0.093 0.1509
Loa Loa (eye worm) proprotein convertase 2 0.005 0.0097 0.0097
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0243 0.0291
Loa Loa (eye worm) histone deacetylase 11 0.0418 0.2407 0.2407
Toxoplasma gondii histone deacetylase HDAC1 0.0406 0.2329 0.4842
Trypanosoma cruzi histone deacetylase 1, putative 0.0619 0.3665 0.6386
Trypanosoma brucei antigen, putative 0.0058 0.0145 0.0193
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.0482 0.1001
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.1629 1 1
Toxoplasma gondii histone deacetylase HDAC3 0.0619 0.3665 0.7621
Trypanosoma brucei calpain-like protein, putative 0.0058 0.0145 0.0193
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0099 0.0405 0.038
Plasmodium falciparum prefoldin subunit 6, putative 0.0095 0.0379 0.0887
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0195 0.1005 0.1705
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0195 0.1005 0.2621
Echinococcus granulosus cathepsin b 0.0295 0.1632 0.2821
Brugia malayi Matrixin family protein 0.0222 0.1173 0.1173
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.0482 0.1001
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0946 0.5718 1
Loa Loa (eye worm) hypothetical protein 0.0216 0.1137 0.1137
Giardia lamblia Cathepsin B precursor 0.0102 0.0422 0.021
Loa Loa (eye worm) hypothetical protein 0.0183 0.093 0.093
Entamoeba histolytica hypothetical protein, conserved 0.0084 0.0308 0.0476
Plasmodium vivax subtilisin-like protease 1 0.005 0.0097 0.0048
Giardia lamblia Cathepsin B precursor 0.0102 0.0422 0.021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0041 0.0039 0.0039
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0048 0.0079 0.0055
Loa Loa (eye worm) hypothetical protein 0.0801 0.4809 0.4809
Plasmodium falciparum plasmepsin III 0.0099 0.0405 0.0958
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0639 0.1076
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0243 0.1237
Brugia malayi NAD-dependent deacetylase SIRT1 0.0625 0.3699 0.3699
Echinococcus granulosus calpain 7 C02 family 0.0058 0.0145 0.0209
Brugia malayi hypothetical protein 0.0237 0.1268 0.1268
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0085 0.0316 0.0508
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0085 0.0316 0.0316
Schistosoma mansoni histone deacetylase 4 5 0.0406 0.2329 0.2308
Loa Loa (eye worm) fibroinase 0.0048 0.0079 0.0079
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0536 0.3145 0.5479
Echinococcus multilocularis histone deacetylase 0.0406 0.2329 0.4045
Brugia malayi Matrixin family protein 0.0536 0.3146 0.3146
Brugia malayi histone deacetylase 3 (HD3) 0.0619 0.3665 0.3665
Loa Loa (eye worm) hypothetical protein 0.0112 0.0482 0.0482
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0151 0.0202
Brugia malayi Cathepsin L-like precursor 0.0048 0.0079 0.0079
Leishmania major DNA repair protein, putative 0.0059 0.0149 0.02
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0084 0.0308 0.048
Mycobacterium ulcerans hypothetical protein 0.0044 0.006 0.0189
Echinococcus multilocularis membrane bound transcription factor site 1 0.005 0.0097 0.0123
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0482 0.0714
Mycobacterium leprae conserved hypothetical protein 0.0112 0.0482 0.229
Echinococcus multilocularis calpain 7 (C02 family) 0.0058 0.0145 0.0209
Brugia malayi Matrixin family protein 0.0222 0.1173 0.1173
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0084 0.0308 0.0495
Entamoeba histolytica prolyl oligopeptidase family protein 0.0084 0.0308 0.0476
Schistosoma mansoni hypothetical protein 0.0041 0.0039 0.0013
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0183 0.093 0.1588
Schistosoma mansoni histone deacetylase 1 2 3 0.025 0.1348 0.1325
Schistosoma mansoni P2X receptor subunit 0.0068 0.0205 0.0179
Brugia malayi prolyl oligopeptidase family protein 0.0084 0.0308 0.0308
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0243 0.0365
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0243 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Leishmania major hypothetical protein, conserved 0.005 0.0094 0.0102
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0084 0.0308 0.048
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0243 0.0291
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0195 0.1005 0.1694
Loa Loa (eye worm) transcriptional regulator 0.0195 0.1005 0.1005
Loa Loa (eye worm) beta-lactamase 0.0112 0.0482 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0097 0.0031
Leishmania major hypothetical protein, conserved 0.0112 0.0482 0.0785
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0084 0.0084
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Loa Loa (eye worm) hypothetical protein 0.0126 0.057 0.057
Schistosoma mansoni P2X receptor subunit 0.0068 0.0205 0.0179
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.0482 0.0482
Brugia malayi calpain 5 0.0041 0.0036 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0482 0.0457
Loa Loa (eye worm) transcriptional regulator 0.0195 0.1005 0.1005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Loa Loa (eye worm) fli-1 protein 0.0213 0.112 0.112
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0084 0.0308 0.0641
Loa Loa (eye worm) hypothetical protein 0.027 0.1476 0.1476
Leishmania major cathepsin L-like protease 0.0096 0.0382 0.0609
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0026
Plasmodium vivax histone deacetylase 2, putative 0.0406 0.2329 0.6271
Plasmodium falciparum subtilisin-like protease 1 0.005 0.0097 0.0103
Brugia malayi Ets-domain containing protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0237 0.1268 0.1268
Echinococcus granulosus calpain 0.0058 0.0145 0.0209
Brugia malayi prolyl oligopeptidase family protein 0.0801 0.4809 0.4809
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0058 0.0145 0.0193
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0154 0.0747 0.0722
Entamoeba histolytica cysteine protease, putative 0.0048 0.0079 0.0076
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0084 0.0308 0.048
Loa Loa (eye worm) transcriptional regulator 0.0946 0.5718 0.5718
Leishmania major cathepsin L-like protease 0.0048 0.0079 0.0076
Loa Loa (eye worm) hypothetical protein 0.0222 0.1173 0.1173
Onchocerca volvulus Cathepsin F homolog 0.0048 0.0079 0.0165
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0195 0.1005 0.1641
Loa Loa (eye worm) endoprotease bli-4 0.005 0.0097 0.0097
Brugia malayi Protein kinase domain containing protein 0.0076 0.0261 0.0261
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0625 0.3699 0.642
Mycobacterium tuberculosis Conserved protein 0.0112 0.0482 0.1001
Schistosoma mansoni inositol monophosphatase 0.0074 0.0243 0.0218
Echinococcus granulosus calpain 5 0.0058 0.0145 0.0209
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.0482 0.2598
Loa Loa (eye worm) inositol-1 0.0074 0.0243 0.0243
Loa Loa (eye worm) subtilase 0.1629 1 1
Loa Loa (eye worm) cysteine protease 0.0048 0.0079 0.0079
Plasmodium falciparum histone deacetylase 1 0.0619 0.3665 0.9997
Loa Loa (eye worm) hypothetical protein 0.0095 0.0379 0.0379
Brugia malayi Pax transcription factor protein 2 0.0291 0.1604 0.1604
Brugia malayi endoprotease bli-4 precursor 0.005 0.0097 0.0097
Loa Loa (eye worm) cathepsin B 0.0102 0.0422 0.0422
Brugia malayi beta-lactamase family protein 0.0112 0.0482 0.0482
Echinococcus multilocularis inhibitor of apoptosis protein 0.0388 0.2215 0.3846
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.0482 0.1001
Loa Loa (eye worm) matrix metalloproteinase 0.0222 0.1173 0.1173
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0079 0.0076
Brugia malayi calpain family protein 1 0.0154 0.0747 0.0747
Leishmania major cysteine peptidase A (CPA) 0.0048 0.0079 0.0076
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0195 0.1005 0.1705
Plasmodium vivax histone deacetylase, putative 0.0406 0.2329 0.6271
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0195 0.1005 0.2238
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0195 0.0584
Trypanosoma cruzi prefoldin subunit, putative 0.0095 0.0379 0.0604
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0806 0.4841 0.8459
Toxoplasma gondii aspartyl protease ASP3 0.0619 0.3666 0.7623
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0205 0.0314
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0319 0.178 0.307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0096 0.0382 0.0609
Loa Loa (eye worm) matrixin family protein 0.0492 0.2868 0.2868
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.005 0.0097 0.04
Echinococcus granulosus chromatin regulatory protein sir2 0.0946 0.5718 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0946 0.5718 1
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.061 0.3607 0.6291
Schistosoma mansoni histone deacetylase hda2 0.0412 0.2366 0.2346
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0714 0.4261 0.995
Loa Loa (eye worm) histone deacetylase 0.0406 0.2329 0.2329
Mycobacterium ulcerans hypothetical protein 0.0112 0.0482 0.2598
Brugia malayi hypothetical protein 0.0126 0.057 0.057
Leishmania major histone deacetylase, putative 0.0406 0.2329 0.4035
Schistosoma mansoni site-1 peptidase (S08 family) 0.005 0.0097 0.007
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0222 0.0343
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0247 0.1331 0.228
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0625 0.3699 0.642
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0183 0.093 0.1934
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0214 0.1122 0.1098
Echinococcus multilocularis cathepsin b 0.0295 0.1632 0.2821
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0084 0.0308 0.0406
Plasmodium falciparum plasmepsin II 0.0183 0.093 0.2414
Echinococcus granulosus cathepsin l cysteine peptidase 0.0048 0.0079 0.0093
Echinococcus granulosus histone deacetylase 6 0.0406 0.2329 0.4045
Brugia malayi prolyl oligopeptidase family protein 0.0084 0.0308 0.0308
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0295 0.1632 0.161
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0319 0.178 0.307
Echinococcus granulosus geminin 0.0205 0.1065 0.1824
Trichomonas vaginalis esterase, putative 0.0112 0.0482 0.0714
Trypanosoma cruzi cysteine peptidase, putative 0.0096 0.0382 0.0609
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0164 0.0812 0.0788
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0364 0.2064 0.3569
Loa Loa (eye worm) hypothetical protein 0.0619 0.3665 0.3665
Schistosoma mansoni survival motor neuron protein 0.0048 0.0084 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0195 0.1005 0.258
Brugia malayi Cathepsin L-like precursor 0.0048 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0247 0.1331 0.1331
Toxoplasma gondii subtilisin SUB11 0.005 0.0097 0.0201
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0625 0.3699 0.642
Loa Loa (eye worm) hypothetical protein 0.0048 0.0079 0.0079
Plasmodium vivax histone deacetylase 1, putative 0.0619 0.3665 0.9997
Brugia malayi Trypsin family protein 0.0216 0.1137 0.1137
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0145 0.0193
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0216 0.1137 0.1114
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0094 0.0102
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0243 0.0363
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0295 0.1632 0.161
Trypanosoma brucei oligopeptidase b 0.0319 0.178 0.307
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.018 0.0913 0.0889
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0295 0.1632 0.2809
Toxoplasma gondii histone deacetylase HDAC4 0.0418 0.2407 0.5004
Trypanosoma cruzi major cysteine proteinase, putative 0.0064 0.0183 0.0259
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0145 0.0193
Mycobacterium ulcerans Sir2-like regulatory protein 0.0195 0.1005 0.5577
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0319 0.178 0.307
Echinococcus multilocularis histone deacetylase 3 0.0619 0.3665 0.6392
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Plasmodium falciparum histone deacetylase, putative 0.0406 0.2329 0.6292
Echinococcus granulosus WGR domain containing protein 0.014 0.0657 0.1109
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0094 0.0195
Schistosoma mansoni histone deacetylase 4 5 0.0406 0.2329 0.2308
Brugia malayi Cathepsin L-like precursor 0.0048 0.0079 0.0079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0058 0.0145 0.0193
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.005 0.0097 0.0088
Loa Loa (eye worm) hypothetical protein 0.0154 0.0747 0.0747
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0076 0.0261 0.0506
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0039 0.0026 0.0026
Plasmodium vivax aspartyl protease, putative 0.0619 0.3666 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0876 0.5278 0.9227
Plasmodium falciparum plasmepsin IX 0.0619 0.3666 1
Echinococcus multilocularis calpain A 0.0165 0.0813 0.1383
Toxoplasma gondii ABC1 family protein 0.0112 0.0482 0.1003
Schistosoma mansoni histone deacetylase 0.0619 0.3665 0.3648
Schistosoma mansoni hypothetical protein 0.0048 0.0084 0.0058
Onchocerca volvulus Cell death protein 3 homolog 0.0126 0.057 0.1185
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0946 0.5718 0.9934
Brugia malayi transcriptional regulator, Sir2 family protein 0.0195 0.1005 0.1005
Plasmodium vivax subtilisin-like protease 2, putative 0.005 0.0097 0.0048
Loa Loa (eye worm) hypothetical protein 0.0388 0.2215 0.2215
Plasmodium falciparum plasmepsin X 0.0619 0.3666 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0099 0.0405 0.038
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0295 0.1632 0.161
Brugia malayi Histone deacetylase family protein 0.0406 0.2329 0.2329
Plasmodium falciparum cysteine proteinase falcipain 3 0.0048 0.0079 0.0055
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0195 0.1005 0.2621
Loa Loa (eye worm) hypothetical protein 0.0169 0.0839 0.0839
Leishmania major histone deacetylase, putative 0.0406 0.2329 0.4035
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.0482 0.1001
Mycobacterium ulcerans hydrolase 0.027 0.1476 0.8264
Echinococcus granulosus poly (ADP ribose) polymerase 0.014 0.0657 0.1109
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Toxoplasma gondii histone deacetylase HDAC2 0.0619 0.3665 0.7621
Schistosoma mansoni chromatin regulatory protein sir2 0.0625 0.3699 0.3682
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0097 0.0031
Trichomonas vaginalis histone deacetylase, putative 0.0619 0.3665 0.6359
Loa Loa (eye worm) hypothetical protein 0.0388 0.2215 0.2215
Entamoeba histolytica histone deacetylase, putative 0.0619 0.3665 0.6344
Plasmodium falciparum plasmepsin VIII, putative 0.0099 0.0405 0.0958
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0319 0.178 0.4076
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0083 0.0301 0.0467
Entamoeba histolytica hypothetical protein 0.007 0.0219 0.0321
Echinococcus granulosus Dipeptidyl peptidase 9 0.0084 0.0308 0.0495
Onchocerca volvulus 0.0112 0.0482 0.1003
Brugia malayi prolyl oligopeptidase family protein 0.0084 0.0308 0.0308
Trypanosoma cruzi oligopeptidase b 0.0319 0.178 0.307
Onchocerca volvulus 0.0039 0.0026 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0482 0.0714
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0102 0.0422 0.068
Echinococcus multilocularis neuroendocrine convertase 2 0.005 0.0097 0.0123
Brugia malayi calpain family protein 1 0.0154 0.0747 0.0747
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0308 0.0406
Toxoplasma gondii PAN domain-containing protein 0.0321 0.1793 0.3728
Trypanosoma cruzi prefoldin subunit, putative 0.0095 0.0379 0.0604
Entamoeba histolytica prolyl oligopeptidase family protein 0.0084 0.0308 0.0476
Toxoplasma gondii subtilisin SUB1 0.005 0.0097 0.0201
Plasmodium vivax plasmepsin V, putative 0.0099 0.0405 0.0909
Plasmodium vivax aspartyl protease, putative 0.0619 0.3666 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0952 0.5756 1
Loa Loa (eye worm) sirtuin 4 0.0195 0.1005 0.1005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.0482 0.0801
Loa Loa (eye worm) hypothetical protein 0.006 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0099 0.0405 0.0405
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Echinococcus granulosus furin 0.005 0.0097 0.0123
Entamoeba histolytica hypothetical protein 0.011 0.0473 0.0765
Loa Loa (eye worm) hypothetical protein 0.0216 0.1137 0.1137
Schistosoma mansoni calpain (C02 family) 0.0058 0.0145 0.0119
Schistosoma mansoni inhibitor of apoptosis protein 0.0388 0.2215 0.2195
Schistosoma mansoni chromatin regulatory protein sir2 0.0946 0.5718 0.5707
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0084 0.0308 0.048
Brugia malayi Cathepsin L-like precursor 0.0048 0.0079 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0261 0.0396
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Plasmodium falciparum subtilisin-like protease 2 0.005 0.0097 0.0103
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.006 0.0042
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0084 0.0308 0.0476
Schistosoma mansoni memapsin-2 (A01 family) 0.0099 0.0405 0.038
Trichomonas vaginalis histone deacetylase, putative 0.0619 0.3665 0.6359
Trypanosoma cruzi histone deacetylase, putative 0.0406 0.2329 0.4035
Loa Loa (eye worm) hypothetical protein 0.0186 0.0948 0.0948
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0946 0.5718 1
Toxoplasma gondii subtilisin SUB2 0.005 0.0097 0.0201
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0205 0.0314
Onchocerca volvulus 0.0315 0.1754 0.3648
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0806 0.4841 0.8459
Onchocerca volvulus 0.0112 0.0482 0.1003
Echinococcus granulosus histone deacetylase 1 0.0619 0.3665 0.6392
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0084 0.0308 0.0283
Loa Loa (eye worm) hypothetical protein 0.0112 0.0482 0.0482
Echinococcus granulosus poly ADP ribose polymerase 1 0.045 0.2603 0.4526
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0183 0.093 0.093
Echinococcus granulosus acylamino acid releasing enzyme 0.0084 0.0308 0.0495
Plasmodium vivax aspartyl protease, putative 0.0099 0.0405 0.0909
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0164 0.0812 0.138
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0205 0.0314
Onchocerca volvulus 0.0048 0.0079 0.0165
Trypanosoma cruzi DNA repair protein, putative 0.0059 0.0149 0.02
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.0482 0.2598
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0122 0.0545 0.052
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0946 0.5718 1
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0222 0.0343
Brugia malayi Trypsin family protein 0.0039 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0222 0.1173 0.1173
Schistosoma mansoni cathepsin D (A01 family) 0.1003 0.6074 0.6064
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0099 0.0405 0.038
Brugia malayi KE2 family protein 0.0095 0.0379 0.0379
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Loa Loa (eye worm) histone deacetylase 7A 0.0406 0.2329 0.2329
Trichomonas vaginalis histone deacetylase, putative 0.0619 0.3665 0.6359
Echinococcus multilocularis histone deacetylase 6 0.0406 0.2329 0.4045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0639 0.0614
Loa Loa (eye worm) hypothetical protein 0.0112 0.0482 0.0482
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0059 0.0149 0.02
Onchocerca volvulus 0.0048 0.0079 0.0165
Plasmodium falciparum plasmepsin V 0.0099 0.0405 0.0958
Brugia malayi calpain 7 0.0058 0.0145 0.0145
Brugia malayi celfurPC protein 0.005 0.0097 0.0097
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0801 0.4809 0.4795
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0099 0.0405 0.038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0084 0.0308 0.0641
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Toxoplasma gondii cathepsin B 0.0102 0.0422 0.0878
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0145 0.0193
Schistosoma mansoni cathepsin F (C01 family) 0.0048 0.0079 0.0053
Toxoplasma gondii subtilisin SUB7 0.005 0.0097 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0379 0.0532
Echinococcus granulosus poly (ADP ribose) polymerase 0.007 0.0219 0.0339
Plasmodium vivax aspartyl proteinase, putative 0.0099 0.0405 0.0909
Schistosoma mansoni chromatin regulatory protein sir2 0.0195 0.1005 0.0981
Trypanosoma cruzi prolyl endopeptidase 0.0801 0.4809 0.84
Echinococcus granulosus poly (ADP ribose) polymerase 0.007 0.0219 0.0339
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.005 0.0097 0.04
Onchocerca volvulus 0.0048 0.0079 0.0165
Giardia lamblia Histone deacetylase 0.0619 0.3665 0.6204
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0048 0.0079 0.0055
Loa Loa (eye worm) hypothetical protein 0.0112 0.0482 0.0482
Trypanosoma brucei cysteine peptidase C (CPC) 0.0102 0.0422 0.068
Trypanosoma cruzi cruzipain precursor, putative 0.0096 0.0382 0.0609
Echinococcus granulosus tm gpcr rhodopsin 0.0536 0.3145 0.5479
Brugia malayi WGR domain containing protein 0.0247 0.1331 0.1331
Mycobacterium tuberculosis Conserved protein 0.0112 0.0482 0.1001
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0319 0.178 1
Toxoplasma gondii subtilisin SUB12 0.0085 0.0316 0.0656
Trypanosoma cruzi histone deacetylase, putative 0.025 0.1348 0.2309
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0639 0.0639
Echinococcus granulosus inhibitor of apoptosis protein 0.0388 0.2215 0.3846
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Onchocerca volvulus Matrilysin homolog 0.0222 0.1173 0.2439
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0151 0.0708
Brugia malayi hypothetical protein 0.0039 0.0026 0.0026
Echinococcus granulosus cathepsin l1 0.0048 0.0079 0.0093
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0084 0.0308 0.0495
Onchocerca volvulus 0.0048 0.0084 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0308 0.0406
Echinococcus granulosus poly adp ribose polymerase 2 0.0247 0.1331 0.2293
Loa Loa (eye worm) hypothetical protein 0.0076 0.0261 0.0261
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.005 0.0097 0.0107
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0946 0.5718 1
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.005 0.0097 0.0097
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Echinococcus multilocularis cysteine protease 0.0048 0.0079 0.0093
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0058 0.0145 0.0193
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0058 0.0145 0.0193
Loa Loa (eye worm) hypothetical protein 0.0364 0.2064 0.2064
Entamoeba histolytica prolyl oligopeptidase family protein 0.0084 0.0308 0.0476
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0473 0.0785
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0308 0.048
Trichomonas vaginalis histone deacetylase, putative 0.0619 0.3665 0.6359
Brugia malayi Trypsin family protein 0.0039 0.0026 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.005 0.0097 0.0031
Trypanosoma brucei prolyl endopeptidase 0.0801 0.4809 0.84
Echinococcus granulosus calpain A 0.0058 0.0145 0.0209
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0183 0.093 0.0906
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0195 0.1005 0.1641

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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