Detailed information for compound 1554037

Basic information

Technical information
  • TDR Targets ID: 1554037
  • Name: N-(3-morpholin-4-yl-3-oxo-1-pyridin-3-ylprop- 1-en-2-yl)furan-2-carboxamide
  • MW: 327.335 | Formula: C17H17N3O4
  • H donors: 1 H acceptors: 3 LogP: 0.81 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(/C(=C/c1cccnc1)/NC(=O)c1ccco1)N1CCOCC1
  • InChi: 1S/C17H17N3O4/c21-16(15-4-2-8-24-15)19-14(11-13-3-1-5-18-12-13)17(22)20-6-9-23-10-7-20/h1-5,8,11-12H,6-7,9-10H2,(H,19,21)/b14-11-
  • InChiKey: NHRGRXHJDOMWFX-KAMYIIQDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(Z)-3-morpholin-4-yl-3-oxo-1-pyridin-3-ylprop-1-en-2-yl]furan-2-carboxamide
  • N-[1-(morpholine-4-carbonyl)-2-(3-pyridyl)vinyl]furan-2-carboxamide
  • N-[(Z)-1-(morpholine-4-carbonyl)-2-(3-pyridyl)vinyl]furan-2-carboxamide
  • N-[(Z)-1-(morpholino-oxomethyl)-2-(3-pyridyl)vinyl]-2-furancarboxamide
  • N-[1-(morpholino-oxomethyl)-2-(3-pyridyl)vinyl]-2-furancarboxamide
  • N-[(Z)-1-(morpholine-4-carbonyl)-2-(3-pyridyl)vinyl]-2-furamide
  • N-[1-(morpholine-4-carbonyl)-2-(3-pyridyl)vinyl]-2-furamide
  • N-[(Z)-3-morpholin-4-yl-3-oxo-1-pyridin-3-yl-prop-1-en-2-yl]furan-2-carboxamide
  • N-(3-morpholin-4-yl-3-oxo-1-pyridin-3-yl-prop-1-en-2-yl)furan-2-carboxamide
  • MLS000688708
  • SMR000284676
  • BAS 03273470
  • Furan-2-carboxylic acid [1-(morpholine-4-carbonyl)-2-pyridin-3-yl-vinyl]-amide
  • STOCK2S-24067
  • ZINC01823016

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus muscleblind protein 0.0459 0.134 0.4321
Schistosoma mansoni hypothetical protein 0.0064 0.0157 0.0507
Schistosoma mansoni hypothetical protein 0.0012 0.0001 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0018 0.0681
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.001 0.0012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0072 0.0229
Brugia malayi Inositol-1 0.0042 0.0089 0.0473
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0059 0.0308
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0185 0.0252
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0018 0.0681
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0258 0.0831
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0098 0.0456
Mycobacterium tuberculosis Conserved protein 0.0074 0.0185 0.0252
Brugia malayi hypothetical protein 0.0078 0.0199 0.1059
Echinococcus multilocularis muscleblind protein 0.0459 0.134 0.1339
Echinococcus multilocularis zinc finger protein 0.0026 0.0044 0.0043
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0098 0.0097
Loa Loa (eye worm) oxidoreductase 0.0015 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.0039 0.008 0.0423
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0009 0.0043
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0185 0.0984
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0059 0.0189
Onchocerca volvulus 0.0104 0.0276 0.1286
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0072 0.0071
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0004 0.0132
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0078 0.0362
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0089 0.0414
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0018 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0071
Loa Loa (eye worm) hypothetical protein 0.0459 0.134 0.7151
Echinococcus multilocularis cpg binding protein 0.0064 0.0157 0.0156
Brugia malayi nuclear hormone receptor 0.0015 0.0009 0.0043
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0479
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0158 0.0157
Trypanosoma brucei glucosidase, putative 0.0038 0.0078 0.3146
Brugia malayi isocitrate dehydrogenase 0.0047 0.0106 0.0561
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0089 0.0089
Brugia malayi Pre-SET motif family protein 0.0092 0.0242 0.1286
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0185 0.0184
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0228 0.0732
Trichomonas vaginalis esterase, putative 0.0074 0.0185 0.0863
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.001 0.0048
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0007 0.0028
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0059 0.0189
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0018 0.0681
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0098 0.3969
Trichomonas vaginalis set domain proteins, putative 0.0725 0.2137 1
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0004 0.0015
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0018 0.0054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Loa Loa (eye worm) hypothetical protein 0.0052 0.0119 0.0632
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0247 0.115
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0018 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0172 0.0912
Echinococcus multilocularis chromobox protein 1 0.0069 0.0172 0.0171
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0109 0.0293 0.0292
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.001 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0059 0.0058
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.0477 0.254
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0185 0.0598
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0018 0.0089
Schistosoma mansoni cript-related 0.0012 0.0001 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0099 0.0134
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0001 0.0003
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0059 0.0308
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0185 0.0248
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0052 0.0119 0.0632
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0059 0.027
Echinococcus granulosus GPCR family 2 0.0065 0.0158 0.0507
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0247 0.0246
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.001 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0079 0.3165
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0081 0.0426
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0009 0.0043
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0076 0.0091
Loa Loa (eye worm) hypothetical protein 0.0074 0.0185 0.0984
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0099 0.046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0145 0.0767
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0059 0.0058
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0106 0.0144
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0013
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0106 0.428
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0106 0.0105
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0145 0.0192
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0098 0.3969
Toxoplasma gondii thioredoxin reductase 0.0038 0.0079 0.0106
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.001 0.0369
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0119 0.015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0071
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0185 0.0248
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0119 0.015
Toxoplasma gondii pantoate-beta-alanine ligase 0.2454 0.7317 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0018 0.0681
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0078 0.0362
Mycobacterium ulcerans beta-lactamase 0.0074 0.0185 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0059 0.0308
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0477 0.0476
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0004 0.0129
Loa Loa (eye worm) hypothetical protein 0.0074 0.0185 0.0984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0079 0.0106
Entamoeba histolytica hypothetical protein 0.0078 0.0199 0.7703
Brugia malayi hypothetical protein 0.0017 0.0014 0.0071
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0078 0.0413
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0009 0.0026
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0089 0.6072
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0004 0.0221
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0059 0.0189
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0004 0.0129
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0059 0.0058
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0078 0.0249
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0009 0.0008
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 0.0106 0.428
Schistosoma mansoni hypothetical protein 0.0065 0.0158 0.051
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0254 0.0334
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0016 0.0015
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0004 0.0004
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0098 0.0315
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0004 0.0017
Onchocerca volvulus 0.0015 0.001 0.0042
Brugia malayi glutathione reductase 0.0038 0.0079 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.0576 0.307
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0038 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0104 0.0483
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.008 0.329
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0405 0.0404
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0258 0.0257
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0089 0.0117
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0089 0.0286
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0009 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0038 0.0195
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.001 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0009 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0059 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0098 0.0318
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0078 0.3146
Toxoplasma gondii propionate-CoA ligase 0.0015 0.001 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0019 0.0057
Treponema pallidum NADH oxidase 0.0013 0.0004 0.0221
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0018 0.0017
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.001 0.0012
Plasmodium vivax glutathione reductase, putative 0.0038 0.0079 0.3228
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0074 0.0185 0.0984
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.001 0.0376
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0185 0.0252
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0078 0.0362
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0071
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0016 0.0047
Schistosoma mansoni hypothetical protein 0.0078 0.0199 0.0643
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0497 0.2323
Echinococcus multilocularis geminin 0.1046 0.31 0.3099
Brugia malayi nuclear receptor NHR-88 0.0015 0.0009 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0247 0.0795
Brugia malayi nuclear receptor RXR 0.0015 0.0009 0.0043
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.001 0.0008
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0106 0.0342
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.008 1
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0009 0.0026
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0185 0.0252
Loa Loa (eye worm) hypothetical protein 0.0098 0.0258 0.1375
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0247 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0158 0.0839
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0181 0.0508 0.2706
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0274 0.0786 0.4191
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0009 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0526 0.2457
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0004 0.0129
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0172 0.08
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0145 0.0673
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0308
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0119 0.0157
Trypanosoma brucei polo-like protein kinase 0.0094 0.0247 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0225 0.0306
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.001 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0059 0.0189
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0078 0.0362
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0254 0.0346
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0014 0.0071
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.001 0.063
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0038 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0098 0.0315
Onchocerca volvulus 0.0074 0.0185 0.0863
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.001 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0059 0.0186
Brugia malayi nuclear receptor NHR-67 0.0015 0.0009 0.0043
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0007 0.0028
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0145 0.5969
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0059 0.0308
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0327 0.0445
Onchocerca volvulus 0.0059 0.0141 0.0656
Brugia malayi AMP-binding enzyme family protein 0.0015 0.001 0.0048
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0018 0.0681
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.0508 0.0507
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0007 0.0232
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0007 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0119 0.0157
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0089 0.0121
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0018 0.0057
Loa Loa (eye worm) acetyltransferase 0.0147 0.0405 0.216
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0007 0.0243
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0059 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Leishmania major hypothetical protein, conserved 0.0015 0.001 0.0379
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0145 0.0464
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0129
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0078 0.0362
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0078 0.0362
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0009 0.0029
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.001 0.0369
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.001 0.0012
Echinococcus multilocularis GPCR, family 2 0.0065 0.0158 0.0157
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0132 0.07
Brugia malayi nuclear hormone receptor 0.0031 0.0059 0.0308
Echinococcus granulosus chromobox protein 1 0.0069 0.0172 0.0551
Loa Loa (eye worm) hypothetical protein 0.0052 0.0119 0.0632
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0098 0.0521
Brugia malayi hypothetical protein 0.0274 0.0786 0.4191
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0185 0.0863
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0082 0.3129
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0059 0.0308
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0059 0.0189
Onchocerca volvulus 0.0074 0.0185 0.0863
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0185 0.0863
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0029 0.0151
Loa Loa (eye worm) hypothetical protein 0.0074 0.0185 0.0984
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.001 0.0048
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0119 0.0157
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0163 0.0524
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0776 0.363
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0009 0.0026
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0158 0.0507
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0163 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0776 0.363
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0776 0.363
Plasmodium falciparum glutathione reductase 0.0013 0.0004 0.0221
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0059 0.0058
Onchocerca volvulus 0.0725 0.2137 1
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0009 0.0043
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0014 0.0071
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0059 0.027
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0018 0.065
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0386 0.1243
Brugia malayi beta-lactamase family protein 0.0074 0.0185 0.0984
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.001 0.0369
Echinococcus granulosus zinc finger protein 0.0026 0.0044 0.0138
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0247 0.115
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0258 1
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0038 0.0037
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0014 0.0007 0.0257
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0004 0.0004
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0018 0.0681
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0098 0.0456
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0405 0.216
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0119 0.4595
Loa Loa (eye worm) hypothetical protein 0.0298 0.0857 0.4572
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0004 0.0129
Toxoplasma gondii ABC1 family protein 0.0074 0.0185 0.0252
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.001 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0059 0.0308
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0098 0.0097
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0074 0.01
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0185 0.0595
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0098 0.0097
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0007 0.0243
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0009 0.0029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0199 0.064
Trichomonas vaginalis chromobox protein, putative 0.0042 0.009 0.0415
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0099 0.0317
Brugia malayi CHD4 protein 0.0017 0.0014 0.0071
Onchocerca volvulus 0.0099 0.0261 0.1216
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0145 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0242 0.078
Echinococcus multilocularis dnaJ subfamily C 6 0.0064 0.0157 0.0156
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0242 0.0241
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.0349 0.1126
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0059 0.0308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0059 0.0308
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0028 0.0144
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0019 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.001 0.0008
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0185 0.7503
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0009 0.0029
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0034 0.0178
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0071
Schistosoma mansoni survival motor neuron protein 0.0056 0.0132 0.0426
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0106 0.428
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0029 0.0091
Brugia malayi nuclear receptor RXR 0.0017 0.0014 0.0071
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0018 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0098 0.3786
Schistosoma mansoni hypothetical protein 0.0041 0.0086 0.0278
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0254 0.0346
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0004 0.0129
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0078 0.0362
Onchocerca volvulus 0.0015 0.0009 0.0037
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0247 0.9537
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0059 0.0308
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0082 0.3281
Loa Loa (eye worm) hypothetical protein 0.0039 0.008 0.0423
Trichomonas vaginalis helicase, putative 0.0013 0.0005 0.0017
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0079 0.3228
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0018 0.065
Schistosoma mansoni patched 1 0.0042 0.0091 0.0293
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0017
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2454 0.7317 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0004 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0119 0.4818
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0145 0.5853
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0009 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0059 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0497 0.2323
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0009 0.0043
Onchocerca volvulus 0.0052 0.0119 0.0554
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0059 0.0186
Onchocerca volvulus Glucosylceramidase homolog 0.0178 0.0497 0.2323
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0271 0.0776 0.414
Schistosoma mansoni synaptojanin 0.0012 0.0001 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0185 0.024
Onchocerca volvulus 0.003 0.0056 0.0256
Brugia malayi steroid hormone receptor 0.0031 0.0059 0.0308
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0129
Brugia malayi AMP-binding enzyme family protein 0.0015 0.001 0.0048
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0181 0.0508 0.2706
Brugia malayi Heterochromatin protein 1 0.0069 0.0172 0.0912
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0009 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.0293 0.0944
Loa Loa (eye worm) hypothetical protein 0.0052 0.0119 0.0631
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0185 0.7653
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0225 0.0306
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0199 0.0643
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0089 0.3605
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.0382 0.2037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Loa Loa (eye worm) hypothetical protein 0.0074 0.0185 0.0984
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0009 0.0026
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0009 0.0037
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0145 0.5853
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0508 0.1638
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0004 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0074 0.01
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0119 0.0632
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0042 0.0132
Schistosoma mansoni hypothetical protein 0.0407 0.1185 0.3824
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.001 0.0008
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.009 0.0415
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0129
Loa Loa (eye worm) beta-lactamase 0.0074 0.0185 0.0984
Echinococcus multilocularis chromobox protein 1 0.0069 0.0172 0.0171
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0019 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0119 0.0157
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0009 0.0008
Schistosoma mansoni cpg binding protein 0.0064 0.0157 0.0506
Entamoeba histolytica hypothetical protein 0.0078 0.0199 0.7703
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0004 0.0132
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.001 0.0012
Schistosoma mansoni chromobox protein 0.0069 0.0172 0.0554
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0019 0.0018
Mycobacterium ulcerans hypothetical protein 0.0052 0.0119 0.0157
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0263 0.0848
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.0293 0.0944
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.0508 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.002 0.0089
Echinococcus granulosus expressed conserved protein 0.0092 0.0241 0.0773
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0497 0.2323
Mycobacterium ulcerans hypothetical protein 0.0074 0.0185 0.0248
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0176
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0014 0.0046
Brugia malayi hypothetical protein 0.0298 0.0857 0.4572
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0018 0.0681
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0018 0.0089
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0059 0.0186
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.0477 0.254
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0059 0.0189
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0225 0.0306
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.005
Onchocerca volvulus 0.0031 0.0059 0.027
Trypanosoma brucei ISWI complex protein 0.0015 0.001 0.0379
Trypanosoma brucei trypanothione reductase 0.0038 0.0079 0.3165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0129
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0225 0.0306
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0091 0.0479
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0497 0.2323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0039 0.0176
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0158 0.0839
Loa Loa (eye worm) glutathione reductase 0.0038 0.0079 0.0415
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0119 0.0157
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0009 0.0008
Schistosoma mansoni nuclear receptor 0.0015 0.0009 0.0029
Schistosoma mansoni coup transcription factor 0.0031 0.0059 0.0189
Leishmania major trypanothione reductase 0.0038 0.0079 0.3165
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0145 0.5853
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0098 0.3969
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0007 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0007 0.0028
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0059 0.0186
Loa Loa (eye worm) hypothetical protein 0.0139 0.0382 0.2037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0176
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0014 0.0043
Echinococcus multilocularis protein patched 0.0042 0.0091 0.009
Giardia lamblia Kinase, PLK 0.0094 0.0247 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.001 0.0369
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.0508 0.1635
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0199 0.0198
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0059 0.0189
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0007 0.0028
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0004 0.0004
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.001 0.0369
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0018 0.0023
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0004 0.0004
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0098 0.3969
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0508 0.1638
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0026 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0776 0.363
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.001 0.0012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0119 0.4595
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0119 0.0157
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0018 0.0681
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0185 0.0252
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.001 0.0369
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0014 0.0013
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0078 0.0362
Brugia malayi ecdysone receptor 0.0015 0.0009 0.0043
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.0786 0.2532
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0042 0.0135
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0059 0.0186
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.1374 0.1877
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0308
Leishmania major pantothenate kinase subunit, putative 0.0014 0.0007 0.0257
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0059 0.0058
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0059 0.0308
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0119 0.0162
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.008 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0047 0.0215
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0059 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0098 0.0456
Brugia malayi tailless protein 0.0015 0.0009 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.001 0.0008
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0089 0.3605
Echinococcus granulosus dnaJ subfamily C 6 0.0064 0.0157 0.0504
Schistosoma mansoni inositol monophosphatase 0.0042 0.0089 0.0289
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0089 0.0414
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0091 0.029
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0027 0.1073
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0078 0.0106
Leishmania major hypothetical protein, conserved 0.0074 0.0185 0.7503
Schistosoma mansoni kinase 0.0048 0.0108 0.0348
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0004 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0059 0.0058
Echinococcus granulosus geminin 0.1046 0.31 1
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0059 0.0189
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0078 0.3001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0009 0.0043
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.001 0.0008
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0047 0.0106 0.0144
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0018 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0059 0.0308
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0009 0.0029
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.001 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0059 0.0189
Brugia malayi hypothetical protein 0.0017 0.0014 0.0071
Loa Loa (eye worm) hypothetical protein 0.0065 0.0158 0.0839
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0099 0.4081
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0091 0.042
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0071
Echinococcus granulosus chromobox protein 1 0.0069 0.0172 0.0551
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0014 0.0043
Loa Loa (eye worm) DnaJ domain-containing protein 0.0064 0.0157 0.0834
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.001 0.0048
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0106 0.0339
Plasmodium falciparum thioredoxin reductase 0.0038 0.0079 0.5408
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.001 0.0352
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0417
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0059 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Loa Loa (eye worm) hypothetical protein 0.0039 0.008 0.0423
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0098 0.0318
Entamoeba histolytica hypothetical protein 0.0078 0.0199 0.7703
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0637 0.1874 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.0477 0.1535
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.002 0.0089
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0247 1
Onchocerca volvulus 0.0015 0.001 0.0042
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0059 0.0186
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0308
Brugia malayi Bromodomain containing protein 0.0082 0.0209 0.1112
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0119 0.0632
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0007 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0508 0.1638
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 0.0106 0.428
Schistosoma mansoni hypothetical protein 0.0041 0.0086 0.0278
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0047 0.0106 0.4365
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0385 0.0384
Schistosoma mansoni zinc finger protein 0.0015 0.001 0.0033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0596
Loa Loa (eye worm) hypothetical protein 0.0039 0.008 0.0423
Onchocerca volvulus 0.0015 0.001 0.0042
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0098 0.0315
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0247 0.115
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0019 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0247 0.115
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0405 0.1308
Brugia malayi CXXC zinc finger family protein 0.0059 0.0141 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0059 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0059 0.0308
Echinococcus granulosus cpg binding protein 0.0064 0.0157 0.0503
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0119 0.0632
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0007 0.0243
Schistosoma mansoni hypothetical protein 0.0065 0.0158 0.051
Loa Loa (eye worm) hypothetical protein 0.0074 0.0185 0.0984
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.0374
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.1185 0.1184
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0007 0.0032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.0576 0.307
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.0786 0.0785
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0247 0.1311
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.001 0.0012
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0385 0.1238
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0099 0.046
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0185 0.0252
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.001 0.0042
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0247 0.0792
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.001 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.001 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0185 0.0252
Schistosoma mansoni nocturnin 0.0012 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0047 0.0215
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0014 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0185 0.7503
Brugia malayi Bromodomain containing protein 0.0042 0.009 0.0473
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0009 0.0029
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0145 1
Loa Loa (eye worm) hypothetical protein 0.0459 0.134 0.7151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0059 0.0308
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0176
Entamoeba histolytica hypothetical protein 0.0078 0.0199 0.7703
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0078 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0059 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.0374
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0089 0.3605
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0254 0.0346
Loa Loa (eye worm) hypothetical protein 0.0204 0.0576 0.307
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0129
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.008 0.0256
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0007 0.0028
Schistosoma mansoni ap endonuclease 0.006 0.0145 0.0467
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0247 0.115
Mycobacterium tuberculosis Conserved protein 0.0074 0.0185 0.0252
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.0576 0.307
Brugia malayi DnaJ domain containing protein 0.0064 0.0157 0.0834
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0141
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0018 0.0681
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0039 0.0176
Schistosoma mansoni nuclear receptor 0.0015 0.0009 0.0029
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0225 0.0306
Brugia malayi Muscleblind-like protein 0.0459 0.134 0.7151
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0106 0.0105
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0145 0.0144
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0158 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0042 0.009 0.0415
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0004 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0247 0.115
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0104 0.0276 0.0889
Trypanosoma cruzi ISWI complex protein 0.0015 0.001 0.0379
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0048
Schistosoma mansoni cpg binding protein 0.0059 0.0141 0.0455
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0078 0.3146
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0059 0.0058
Mycobacterium tuberculosis Conserved protein 0.0074 0.0185 0.0252
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0032
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.008 0.0108
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0185 0.7503
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0109 0.0293 0.1557
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0017
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0497 0.2323
Schistosoma mansoni hypothetical protein 0.0139 0.0382 0.1234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0082 0.5606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0017
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2454 0.7317 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0029 0.0028
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0477 0.0476
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.001 0.0008
Toxoplasma gondii exonuclease III APE 0.006 0.0145 0.0196
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0078 0.0362
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0059 0.0186
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.001 0.0008
Schistosoma mansoni alpha-glucosidase 0.0147 0.0405 0.1308
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.008 0.0104
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0098 0.3969
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0176
Mycobacterium leprae Probable lipase LipE 0.0074 0.0185 0.024
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.001 0.0369
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0158 0.0507
Plasmodium vivax SET domain protein, putative 0.0092 0.0242 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0119 0.0157
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0145 0.5853
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0059 0.0308
Trypanosoma cruzi ISWI complex protein 0.0015 0.001 0.0379
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0141 0.0749
Schistosoma mansoni hypothetical protein 0.0041 0.0086 0.0278
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0009 0.0037
Brugia malayi Pre-SET motif family protein 0.0637 0.1874 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.001 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0145 0.0673
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.001 0.0012
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0009 0.0008
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0308
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0247 0.115
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0018 0.0681
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0059 0.0189
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0106 0.0144
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0176
Loa Loa (eye worm) hypothetical protein 0.007 0.0176 0.0933
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0089 0.3605
Schistosoma mansoni zinc finger protein 0.0015 0.0009 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0776 0.363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0176
Loa Loa (eye worm) inositol-1 0.0042 0.0089 0.0473
Onchocerca volvulus 0.0015 0.001 0.0042
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0004 0.0129
Brugia malayi chromobox protein homolog 3 0.0039 0.0081 0.0426
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0258 0.1375
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0014 0.0013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0059 0.0189
Brugia malayi ecdysteroid receptor 0.0031 0.0059 0.0308
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0059 0.027
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0172 0.08
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.008 0.0423
Schistosoma mansoni inositol monophosphatase 0.0042 0.0089 0.0289
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0089 0.3438
Schistosoma mansoni cpg binding protein 0.0064 0.0157 0.0506
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0018 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0038 0.0171
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0091 0.029
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.001 0.0012
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.001 0.0048
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0185 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0059 0.0308
Schistosoma mansoni bromodomain containing protein 0.007 0.0174 0.0562
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.001 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0526 0.2457
Brugia malayi beta-lactamase family protein 0.0074 0.0185 0.0984
Brugia malayi Isocitrate dehydrogenase 0.0047 0.0106 0.0561
Brugia malayi hypothetical protein 0.0015 0.0009 0.0043
Trichomonas vaginalis protein kinase inhibitor, putative 0.0064 0.0157 0.0731
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0007 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.0508 0.1635
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0497 0.2323
Echinococcus granulosus histone lysine methyltransferase setb 0.0109 0.0293 0.0941
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0099 0.0134
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0018 0.0681
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0247 0.115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0776 0.363
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.001 0.0008
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.001 0.0008
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0081 0.0374
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0308
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0308
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0014 0.0046
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0091 0.009
Schistosoma mansoni ap endonuclease 0.006 0.0145 0.0467
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0106 0.428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0119 0.4818
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0059 0.0308
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0145 0.0767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0043
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0018 0.0685
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0007 0.0243
Brugia malayi nuclear receptor NHR-88 0.0031 0.0059 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0017
Mycobacterium ulcerans lipase LipD 0.0074 0.0185 0.0248
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.001 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0015 0.001 0.0048
Schistosoma mansoni alpha glucosidase 0.0038 0.0078 0.0252
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0014 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0129
Schistosoma mansoni alpha-glucosidase 0.0147 0.0405 0.1308
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0004 0.0129
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0145 0.5582
Schistosoma mansoni synaptojanin 0.0012 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0041 0.0086 0.0278
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0059 0.0308
Brugia malayi Thioredoxin reductase 0.0038 0.0079 0.0415
Schistosoma mansoni hypothetical protein 0.0056 0.0132 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0078 0.3001
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.001 0.0369
Schistosoma mansoni hypothetical protein 0.1046 0.31 1
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0059 0.0058
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0225 0.0294
Loa Loa (eye worm) hypothetical protein 0.0045 0.0098 0.0521
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0059 0.0308
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0048
Giardia lamblia GTOR 0.0018 0.0018 0.0681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0059 0.0308
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0106 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0018 0.0681
Schistosoma mansoni hypothetical protein 0.0065 0.0158 0.051
Onchocerca volvulus 0.0074 0.0185 0.0863
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0145 1
Schistosoma mansoni chromobox protein 0.0069 0.0172 0.0554
Brugia malayi SET domain containing protein 0.0016 0.0012 0.0061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0185 0.0598
Plasmodium falciparum glutathione reductase 0.0038 0.0079 0.5408
Mycobacterium tuberculosis Probable reductase 0.0087 0.0225 0.0306
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0129
Echinococcus multilocularis protein dispatched 1 0.0048 0.0109 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0497 0.2323
Entamoeba histolytica hypothetical protein 0.0024 0.0038 0.142
Schistosoma mansoni hypothetical protein 0.1046 0.31 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0074 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0185 0.0863
Schistosoma mansoni hypothetical protein 0.0021 0.0026 0.0085
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0242 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0017
Onchocerca volvulus 0.0056 0.0132 0.0614
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0292
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0079 0.0415
Onchocerca volvulus 0.0298 0.0857 0.4009
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0185 0.0863
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0129
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.001 0.0369
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0017 0.0075
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0089 0.0414
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0308
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0009 0.0026
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0059 0.0308
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0044 0.0097 0.0512
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0119 0.0162
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0106 0.0561
Schistosoma mansoni zinc finger protein 0.0026 0.0044 0.0141
Brugia malayi PHD-finger family protein 0.0032 0.006 0.0313
Schistosoma mansoni hypothetical protein 0.0065 0.0158 0.051
Plasmodium falciparum thioredoxin reductase 0.0013 0.0004 0.0221
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0001 0.0003
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0018 0.0057
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0247 0.1311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0018 0.0685
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0185 0.0984
Echinococcus granulosus dnaJ subfamily B 0.0407 0.1185 0.3822
Brugia malayi beta-lactamase 0.0074 0.0185 0.0984
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0119 0.4818
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0038 0.0121
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0078 0.0413
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0001 0.0003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0145 0.5853
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0119 0.4595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0018 0.0078
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0009 0.0043
Brugia malayi hypothetical protein 0.0015 0.0009 0.0043
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.001 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0185 0.0863
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0038 0.1488
Echinococcus multilocularis muscleblind protein 1 0.0459 0.134 0.1339
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0078 0.3146
Brugia malayi CHE-14 protein 0.0042 0.0091 0.0479
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0059 0.0189
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0004 0.0129
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0018 0.0054
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.001 0.0012
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0271 0.0776 0.414
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0009 0.0026
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0158 0.0839
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0047 0.0106 0.7312
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.2454 0.7317 1
Onchocerca volvulus 0.0015 0.0009 0.0037
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0038 0.1488
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0145 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0074 0.01
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0104 0.0483
Loa Loa (eye worm) DR-78 0.0015 0.0009 0.0043
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.008 0.5511
Brugia malayi conserved hypotetical protein 0.0015 0.0009 0.0043
Echinococcus multilocularis expressed conserved protein 0.0092 0.0241 0.024
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0014 0.0071

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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