Detailed information for compound 1556964

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 519.772 | Formula: C23H20BrClN2O5
  • H donors: 0 H acceptors: 3 LogP: 3.95 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)[C@@H]1[C@H]2COc3c([C@H]2N2[C@]1(C)C(=O)N(C2=O)c1ccc(cc1)Cl)cc(cc3)Br
  • InChi: 1S/C23H20BrClN2O5/c1-3-31-20(28)18-16-11-32-17-9-4-12(24)10-15(17)19(16)27-22(30)26(21(29)23(18,27)2)14-7-5-13(25)6-8-14/h4-10,16,18-19H,3,11H2,1-2H3/t16-,18+,19-,23+/m1/s1
  • InChiKey: IKKDKEBIRMANSH-WEGMGINNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0039
Giardia lamblia Cysteine protease 0.0118 0.0208 0.205
Plasmodium falciparum serine repeat antigen 2 0.0118 0.0208 0.2258
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0095 0.0352
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0054 0.0054
Mycobacterium tuberculosis Conserved protein 0.0112 0.0195 0.1364
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0006 0.0023
Brugia malayi G-protein alpha subunit 0.0014 0.0005 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0082 0.0745
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0466 0.0888 0.9084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0554 0.1061 0.1061
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0014 0.0005 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0052 0.0462
Loa Loa (eye worm) hypothetical protein 0.0031 0.0038 0.0038
Brugia malayi hypothetical protein 0.0017 0.001 0.0009
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0006 0.0005
Brugia malayi jmjC domain containing protein 0.0075 0.0124 0.0123
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0215 0.1508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Leishmania major pyruvate kinase 0.0034 0.0043 0.0412
Brugia malayi hypothetical protein 0.0021 0.0019 0.0018
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0191 0.1332
Brugia malayi Papain family cysteine protease containing protein 0.0118 0.0208 0.0207
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0118 0.0208 0.205
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0039 0.0127
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0071 0.0697
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0079 0.0793
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.0208 0.1938
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0003 0.0025
Brugia malayi hypothetical protein 0.0147 0.0265 0.0264
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0039
Brugia malayi hypothetical protein 0.0052 0.0079 0.0078
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.0195 0.1991
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0015 0.0024
Trypanosoma cruzi major cysteine proteinase, putative 0.0118 0.0208 0.0761
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0014 0.0005 0.0019
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0118 0.0208 0.205
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0106 0.0184 0.029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0005
Brugia malayi hypothetical protein 0.0015 0.0006 0.0005
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0051 0.0172
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0022
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0118 0.0208 0.2258
Loa Loa (eye worm) DR-78 0.0015 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0126 0.0452
Loa Loa (eye worm) hypothetical protein 0.0038 0.0051 0.0051
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0054 0.0548
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0005 0.0045
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0118 0.0208 0.0754
Brugia malayi Cathepsin L-like precursor 0.0325 0.0613 0.0612
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0015
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0039 0.0062
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0128 0.0227 0.0358
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0079 0.0751
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0118 0.0208 0.1789
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0039 0.0038
Onchocerca volvulus 0.0035 0.0045 0.004
Echinococcus multilocularis GPCR, family 2 0.0017 0.0011 0.0017
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0045 0.0045
Schistosoma mansoni pyruvate kinase 0.0034 0.0043 0.0142
Echinococcus multilocularis pyruvate kinase 0.0017 0.0011 0.0017
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0014 0.0005 0.0005
Brugia malayi intermediate filament protein 0.0055 0.0084 0.0083
Schistosoma mansoni zinc finger protein 0.0015 0.0006 0.0005
Plasmodium vivax glutathione reductase, putative 0.0048 0.0071 0.0697
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0039 0.0039
Giardia lamblia Cathepsin B precursor 0.0512 0.0978 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0054 0.0461
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0006 0.0005
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0043 0.0038
Schistosoma mansoni rab6-interacting 0.0021 0.0019 0.0051
Giardia lamblia Cathepsin L precursor 0.0118 0.0208 0.205
Trichomonas vaginalis esterase, putative 0.0112 0.0195 0.1817
Entamoeba histolytica cysteine protease, putative 0.0118 0.0208 0.1789
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0052 0.047
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0112 0.0195 0.0195
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0006 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0084 0.0084
Giardia lamblia Hypothetical protein 0.0118 0.0208 0.205
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0043 0.0149
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0025 0.004
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0051 0.0189
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.001 0.0002
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0466 0.0888 0.0888
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0014 0.0005 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0039 0.0062
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0006 0.0005
Echinococcus granulosus lamin dm0 0.0055 0.0084 0.031
Brugia malayi cathepsin Z-like cysteine proteinase 0.0118 0.0208 0.0207
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0009 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0195 0.0713
Plasmodium falciparum serine repeat antigen 6 0.0118 0.0208 0.2258
Echinococcus granulosus pyruvate kinase 0.0017 0.0011 0.004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0466 0.0888 0.9084
Brugia malayi cathepsin F-like cysteine proteinase 0.0141 0.0253 0.0252
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0178 0.1659
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0039 0.0038
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0005 0.0018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0048 0.0178
Echinococcus multilocularis pyruvate kinase 0.0034 0.0043 0.0068
Entamoeba histolytica cysteine proteinase 1, putative 0.0259 0.0484 0.4197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0039 0.0039
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0195 0.2112
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.0253 0.0927
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Schistosoma mansoni cathepsin B (C01 family) 0.0118 0.0208 0.0754
Trypanosoma cruzi cysteine proteinase, putative 0.0259 0.0484 0.1785
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0005 0.0018
Onchocerca volvulus 0.0015 0.0006 0.0001
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0259 0.0484 0.1778
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0115 0.0408
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0104 0.018 0.018
Schistosoma mansoni cathepsin C 0.0118 0.0208 0.0754
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0043 0.0436
Toxoplasma gondii aldehyde dehydrogenase 0.0185 0.0339 0.343
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0215 0.1508
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0006 0.001
Echinococcus granulosus cathepsin b 0.1391 0.2698 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0019 0.0029
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0027 0.0043
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0054 0.1351
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0039 0.0038
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0118 0.0208 0.0754
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.1061 1
Echinococcus granulosus phd:f box containing protein 0.002 0.0015 0.0056
Trypanosoma brucei hypothetical protein, conserved 0.0216 0.0399 0.4075
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0118 0.0208 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0118 0.0208 0.1938
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0106 0.4345
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.0688 0.6477
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0011 0.0017
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0118 0.0208 0.2258
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0079 0.0793
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0095 0.015
Trypanosoma cruzi cysteine peptidase, putative 0.0466 0.0888 0.3286
Onchocerca volvulus 0.0055 0.0084 0.0079
Plasmodium falciparum importin beta, putative 0.0035 0.0045 0.0405
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0084 0.0083
Schistosoma mansoni jumonji domain containing protein 0.0157 0.0284 0.1038
Schistosoma mansoni hypothetical protein 0.0037 0.005 0.0168
Loa Loa (eye worm) hypothetical protein 0.0112 0.0195 0.0195
Trypanosoma cruzi cysteine proteinase, putative 0.0259 0.0484 0.1785
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0054 0.0508
Brugia malayi cathepsin L-like cysteine proteinase 0.0118 0.0208 0.0207
Onchocerca volvulus 0.5124 1 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0122 0.1217
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0026
Giardia lamblia Cysteine protease 0.0118 0.0208 0.205
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0142 0.0224
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0051 0.0456
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0333 0.0629 0.0628
Entamoeba histolytica hypothetical protein 0.0024 0.0023 0.0178
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0005 0.0019
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0032 0.0109
Brugia malayi hypothetical protein 0.0017 0.001 0.0009
Onchocerca volvulus Cathepsin L homolog 0.0466 0.0888 0.0884
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0051 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0079 0.0283
Entamoeba histolytica hypothetical protein 0.0036 0.0048 0.0395
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0554 0.1061 0.106
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0005 0.0018
Leishmania major importin beta-1 subunit, putative 0.0028 0.0032 0.03
Schistosoma mansoni ran 0.0026 0.0027 0.0082
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.0015 0.0092
Giardia lamblia Cathepsin B precursor 0.0118 0.0208 0.205
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0084 0.0142 0.0142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0024
Leishmania major hypothetical protein, conserved 0.0216 0.0399 0.406
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0084 0.0083
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0122 0.124
Brugia malayi nuclear receptor NHR-67 0.0015 0.0006 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0178 0.1659
Onchocerca volvulus 0.0466 0.0888 0.0884
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0038 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0466 0.0888 0.8371
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0051 0.0518
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0043 0.0038
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.0943 0.149
Entamoeba histolytica cysteine proteinase 2 0.0259 0.0484 0.4197
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0039 0.0034
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.005 0.0049
Brugia malayi jmjC domain containing protein 0.0198 0.0364 0.0363
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0082 0.0745
Loa Loa (eye worm) hypothetical protein 0.0125 0.0222 0.0222
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0019 0.0069
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0005 0.0004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0071 0.0112
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0019 0.0029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0122 0.0441
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0006 0.0005
Onchocerca volvulus 0.0112 0.0195 0.019
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0006 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.0208 0.1938
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.001 0.0003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.005 0.005
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0051 0.0189
Echinococcus multilocularis cathepsin L cysteine protease 0.0466 0.0888 0.1404
Echinococcus multilocularis pyruvate kinase 0.0027 0.0029 0.0046
Brugia malayi cathepsin Z-like cysteine proteinase 0.0118 0.0208 0.0207
Schistosoma mansoni ap endonuclease 0.0039 0.0054 0.0182
Trypanosoma cruzi cysteine peptidase, putative 0.0466 0.0888 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0118 0.0208 0.1938
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.0688 0.6477
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0039 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.0726 0.6839
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0185 0.0339 0.1258
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1391 0.2698 1
Brugia malayi Bromodomain containing protein 0.006 0.0095 0.0094
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0039 0.0127
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0071 0.045
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0019
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0118 0.0208 0.2258
Entamoeba histolytica hypothetical protein 0.0118 0.0208 0.1789
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0019 0.0029
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0054 0.0446
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0118 0.0208 0.1789
Onchocerca volvulus 0.0325 0.0613 0.0608
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0043 0.0436
Plasmodium vivax vivapain-1 0.0259 0.0484 0.5397
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0253
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.0314 0.1165
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0118 0.0208 0.1938
Echinococcus granulosus pyruvate kinase 0.0017 0.0011 0.004
Brugia malayi Isocitrate dehydrogenase 0.0017 0.001 0.0009
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0054 0.02
Brugia malayi Pre-SET motif family protein 0.0031 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0147 0.0265 0.0265
Echinococcus granulosus pyruvate kinase 0.0034 0.0043 0.0159
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.0195 0.1364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0466 0.0888 0.9084
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0184 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0118 0.0208 0.1938
Schistosoma mansoni importin beta-1 0.0035 0.0045 0.0149
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0023 0.1237
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0039 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0333 0.0629 0.2318
Entamoeba histolytica cysteine protease, putative 0.0118 0.0208 0.1789
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0052 0.0192
Schistosoma mansoni ap endonuclease 0.0039 0.0054 0.0182
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0118 0.0208 0.0754
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0118 0.0208 0.0208
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1391 0.2698 1
Brugia malayi Papain family cysteine protease containing protein 0.0259 0.0484 0.0483
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0039 0.0127
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0027 0.0182
Trypanosoma cruzi major cysteine proteinase, putative 0.0118 0.0208 0.0761
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0015 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.1061 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Schistosoma mansoni protein phosphatase 2C 0.002 0.0015 0.0038
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0005 0.0004
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0027 0.0027
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0009 0.0067
Plasmodium falciparum serine repeat antigen 3 0.0118 0.0208 0.2258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Trichomonas vaginalis set domain proteins, putative 0.0241 0.0448 0.4209
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.0195 0.1364
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0014 0.0005 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0048 0.0076
Brugia malayi hypothetical protein 0.0034 0.0043 0.0042
Brugia malayi Cathepsin L-like precursor 0.0141 0.0253 0.0252
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0126 0.0126
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0215 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0055 0.0084 0.0084
Giardia lamblia Cathepsin B precursor 0.0118 0.0208 0.205
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0015 0.0038
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0039 0.0145
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0006 0.0005
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0006 0.0023
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0005 0.0004
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0023 0.0209
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0005 0.0008
Entamoeba histolytica hypothetical protein 0.0036 0.0048 0.0395
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0484 0.4546
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0195 0.1817
Brugia malayi cathepsin B-like cysteine proteinase 0.1391 0.2698 0.2697
Echinococcus multilocularis lamin dm0 0.0055 0.0084 0.0132
Plasmodium vivax hypothetical protein, conserved 0.006 0.0095 0.0975
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0014 0.0005 0.0004
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0028 0.0105
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0043 0.0042
Schistosoma mansoni cpg binding protein 0.0035 0.0045 0.0148
Plasmodium vivax unspecified product 0.0259 0.0484 0.5397
Loa Loa (eye worm) ctsf protein 0.0466 0.0888 0.0888
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0215 0.1508
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0051 0.0456
Echinococcus granulosus dnaJ subfamily B 0.0494 0.0943 0.3496
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0184 0.0663
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.1061 1
Leishmania major cathepsin L-like protease 0.0466 0.0888 0.9082
Echinococcus granulosus cysteine protease 0.0259 0.0484 0.1793
Echinococcus multilocularis cpg binding protein 0.0037 0.0049 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0051 0.0421
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0118 0.0208 0.0754
Entamoeba histolytica Ran family GTPase 0.0026 0.0027 0.0211
Schistosoma mansoni cathepsin S (C01 family) 0.0118 0.0208 0.0754
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0051 0.0494
Onchocerca volvulus 0.0021 0.0019 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Schistosoma mansoni polycystin 1-related 0.0021 0.0019 0.0051
Loa Loa (eye worm) hypothetical protein 0.0325 0.0613 0.0613
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0006 0.0006
Mycobacterium ulcerans beta-lactamase 0.0112 0.0195 0.5625
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0039 0.0127
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0118 0.0208 0.0754
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Onchocerca volvulus 0.0466 0.0888 0.0884
Echinococcus granulosus RUN 0.0021 0.0019 0.0069
Loa Loa (eye worm) hypothetical protein 0.0118 0.0208 0.0208
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0015
Giardia lamblia Cathepsin B precursor 0.0512 0.0978 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0052 0.0462
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0019 0.0105
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0023 0.4123
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0015 0.0038
Onchocerca volvulus Cathepsin L homolog 0.0466 0.0888 0.0884
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0025 0.004
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Brugia malayi hypothetical protein 0.0014 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.0028 0.0032 0.0255
Brugia malayi isocitrate dehydrogenase 0.0017 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0023 0.0023 0.0066
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0043 0.0149
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.0195 0.1364
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0045
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Echinococcus multilocularis cysteine protease 0.0466 0.0888 0.1404
Brugia malayi Pre-SET motif family protein 0.0212 0.0391 0.039
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Loa Loa (eye worm) RNA binding protein 0.0076 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.0208 0.1938
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0118 0.0208 0.205
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.0208 0.1938
Mycobacterium ulcerans lipase LipD 0.0112 0.0195 0.5625
Brugia malayi nuclear receptor RXR 0.0017 0.001 0.0009
Echinococcus granulosus expressed protein 0.0014 0.0005 0.0018
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0045 0.0456
Leishmania major cysteine peptidase A (CPA) 0.0466 0.0888 0.9082
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0025 0.0487
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0019
Toxoplasma gondii cathepsin CPC1 0.0118 0.0208 0.2076
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0118 0.0208 0.0754
Loa Loa (eye worm) inositol-1 0.0074 0.0122 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0039 0.0038
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0025 0.0214
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0118 0.0208 0.0208
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0006 0.0006
Plasmodium falciparum serine repeat antigen 8 0.0118 0.0208 0.2258
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0039 0.0127
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1391 0.2698 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0051 0.0431
Brugia malayi nuclear receptor NHR-88 0.0015 0.0006 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0052 0.0182
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0039 0.0127
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0039 0.0062
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0015
Plasmodium vivax serine-repeat antigen (SERA) 0.0118 0.0208 0.2258
Echinococcus granulosus cpg binding protein 0.0037 0.0049 0.018
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0052 0.0462
Loa Loa (eye worm) hypothetical protein 0.006 0.0095 0.0095
Schistosoma mansoni ran 0.0026 0.0027 0.0082
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0118 0.0208 0.2258
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0178 0.1659
Plasmodium falciparum serine repeat antigen 5 0.0118 0.0208 0.2258
Schistosoma mansoni rab6-interacting 0.0021 0.0019 0.0051
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0019
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0006 0.0005
Trypanosoma brucei glucosidase, putative 0.0038 0.0052 0.0525
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0005 0.0018
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0118 0.0208 0.2258
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.001 0.0018
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0052 0.0462
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0039 0.0127
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0142 0.0141
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Schistosoma mansoni intermediate filament proteins 0.0055 0.0084 0.0292
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.0195 0.5625
Brugia malayi RNA binding protein 0.0076 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0112 0.0195 0.0195
Brugia malayi steroid hormone receptor 0.0032 0.0039 0.0038
Giardia lamblia Cysteine protease 0.0118 0.0208 0.205
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0015 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0024
Loa Loa (eye worm) fibroinase 0.0466 0.0888 0.0888
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0039 0.0038
Onchocerca volvulus 0.0031 0.0038 0.0033
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0005 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.1061 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0466 0.0888 0.9084
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0079 0.0283
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0011 0.0017
Schistosoma mansoni pyruvate kinase 0.0017 0.0011 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.0208 0.1938
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.0195 0.1364
Giardia lamblia Cysteine protease 0.0118 0.0208 0.205
Schistosoma mansoni lipoxygenase 0.0128 0.0227 0.0823
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0333 0.0629 0.2332
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0333 0.0629 0.2318
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0015 0.0097
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0178 0.1659
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0005 0.0008
Brugia malayi glutathione reductase 0.0048 0.0071 0.007
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0054 1
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0052 0.0502
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0039 0.0034
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0019 0.007
Toxoplasma gondii melibiase subfamily protein 0.0106 0.0184 0.1826
Entamoeba histolytica G protein alpha subunit, putative 0.0014 0.0005 0.0018
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0034 0.0033
Echinococcus multilocularis musashi 0.0055 0.0084 0.0132
Plasmodium falciparum serine repeat antigen 9 0.0118 0.0208 0.2258
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0039 0.0038
Onchocerca volvulus 0.0466 0.0888 0.0884
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0014 0.0005 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0325 0.0613 0.5763
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0039 0.0039
Plasmodium falciparum serine repeat antigen 4 0.0118 0.0208 0.2258
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0005 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0178 0.1659
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.0484 0.4197
Onchocerca volvulus Glucosylceramidase homolog 0.0364 0.0688 0.0684
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0014 0.0005 0.0004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0005 0.0004
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0115 0.0408
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0095 0.0916
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.0195 0.0195
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0005 0.002
Brugia malayi hypothetical protein 0.0021 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0118 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Onchocerca volvulus 0.0021 0.0019 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Schistosoma mansoni cathepsin F (C01 family) 0.0466 0.0888 0.3281
Giardia lamblia Cathepsin L-like protease 0.0118 0.0208 0.205
Schistosoma mansoni alpha-glucosidase 0.0149 0.0267 0.0975
Echinococcus multilocularis cysteine protease 0.0466 0.0888 0.1404
Onchocerca volvulus 0.0055 0.0084 0.0079
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0118 0.0208 0.0207
Loa Loa (eye worm) beta-lactamase 0.0112 0.0195 0.0195
Brugia malayi Importin beta-1 subunit 0.0035 0.0045 0.0044
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0015 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.001 0.0009
Toxoplasma gondii cathepsin CPL 0.0466 0.0888 0.9079
Leishmania major pyruvate kinase 0.0034 0.0043 0.0412
Schistosoma mansoni hypothetical protein 0.006 0.0095 0.0335
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0466 0.0888 1
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.001 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0039 0.0038
Brugia malayi Thioredoxin reductase 0.0048 0.0071 0.007
Echinococcus granulosus GPCR family 2 0.0017 0.0011 0.004
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0178 0.0651
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0121
Giardia lamblia Cathepsin L-like protease 0.0118 0.0208 0.205
Schistosoma mansoni pyruvate kinase 0.0034 0.0043 0.0142
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0067
Loa Loa (eye worm) hypothetical protein 0.0325 0.0613 0.0613
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0038 0.0121
Brugia malayi PHD-finger family protein 0.0022 0.0019 0.0019
Leishmania major hypothetical protein, conserved 0.0052 0.0079 0.0782
Leishmania major cathepsin L-like protease 0.0466 0.0888 0.9082
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0045 0.04
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0124 0.0442
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.0178 0.0661
Trypanosoma cruzi cysteine peptidase, putative 0.0466 0.0888 0.3286
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0466 0.0888 0.0888
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.001 0.0015
Plasmodium falciparum cysteine proteinase falcipain 3 0.0466 0.0888 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0005 0.0019
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0122 0.3399
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0023 0.0084
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0124 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0054 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0333 0.0629 0.2318
Leishmania major cathepsin L-like protease 0.0466 0.0888 0.9082
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0122 0.0192
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0039 0.0038
Schistosoma mansoni inositol monophosphatase 0.0074 0.0122 0.0433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0005 0.0007
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0118 0.0208 0.2258
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0025 0.0487
Echinococcus granulosus bloom syndrome protein 0.0025 0.0025 0.0094
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0025 0.0025
Schistosoma mansoni alpha-glucosidase 0.0149 0.0267 0.0975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.0208 0.1938
Loa Loa (eye worm) hypothetical protein 0.007 0.0115 0.0115
Echinococcus granulosus tar DNA binding protein 0.0076 0.0126 0.0469
Echinococcus granulosus cathepsin b 0.1391 0.2698 1
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.0688 0.6477
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0039 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0039 0.0145
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.0339 0.1243
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0599 0.1149 1
Schistosoma mansoni hypothetical protein 0.002 0.0015 0.0039
Brugia malayi Papain family cysteine protease containing protein 0.0466 0.0888 0.0888
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0095 0.0335
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0043 0.1033
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0052 0.0462
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0011 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0466 0.0888 0.8371
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0435 0.0434
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0005 0.0018
Leishmania major cathepsin L-like protease 0.0466 0.0888 0.9082
Echinococcus granulosus cathepsin L 0.0118 0.0208 0.077
Loa Loa (eye worm) hypothetical protein 0.0054 0.0082 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0178 0.0644
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0466 0.0888 0.9084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Onchocerca volvulus 0.0032 0.0039 0.0034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0466 0.0888 0.8371
Loa Loa (eye worm) hypothetical protein 0.1391 0.2698 0.2698
Onchocerca volvulus 0.0241 0.0448 0.0444
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0005 0.0019
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0185 0.0339 0.2425
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0048 0.0161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0039 0.0145
Loa Loa (eye worm) RecQ helicase 0.0025 0.0025 0.0025
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0043 0.0043
Onchocerca volvulus Cathepsin L homolog 0.0118 0.0208 0.0203
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0184 0.0663
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0006 0.0023
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0043 0.0042
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0027 0.0215
Brugia malayi Cathepsin L-like precursor 0.0466 0.0888 0.0888
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0006 0.0005
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0028 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0039 0.0039
Brugia malayi Inositol-1 0.0074 0.0122 0.0121
Onchocerca volvulus 0.0466 0.0888 0.0884
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0118 0.0208 0.1938
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0039 0.0127
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0599 0.1149 1
Mycobacterium ulcerans hypothetical protein 0.0112 0.0195 0.5625
Brugia malayi hypothetical protein 0.0126 0.0223 0.0222
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0014 0.0005 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0466 0.0888 0.8371
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0126 0.0452
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0023 0.042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0121
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0052 0.0082
Echinococcus granulosus pyruvate kinase 0.0017 0.0011 0.004
Mycobacterium tuberculosis Probable reductase 0.0109 0.0191 0.1332
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0051 0.0179
Brugia malayi nuclear hormone receptor 0.0015 0.0006 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.0688 0.6477
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.0484 0.4197
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0054 0.0483
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.0339 0.1243
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0006 0.0005
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3247 0.6329 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0027 0.0201
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0032 0.0276
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0039 0.0145
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0038 0.0323
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0027 0.01
Loa Loa (eye worm) hypothetical protein 0.0112 0.0195 0.0195
Brugia malayi ecdysteroid receptor 0.0032 0.0039 0.0038
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0118 0.0208 0.2258
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0035
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.001 0.0018
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0038 0.0139
Onchocerca volvulus 0.0118 0.0208 0.0203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0466 0.0888 0.8371
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0466 0.0888 0.9084
Brugia malayi TAR-binding protein 0.0076 0.0126 0.0126
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0106 0.0713
Entamoeba histolytica cysteine protease, putative 0.0118 0.0208 0.1789
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0466 0.0888 0.8371
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0039 0.0039
Brugia malayi RNA, U transporter 1 0.0099 0.0171 0.017
Echinococcus granulosus cathepsin L 0.0259 0.0484 0.1793
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0039 0.0145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0333 0.0629 0.0994
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0052 0.0052
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0466 0.0888 0.1404
Brugia malayi hypothetical protein 0.0036 0.0048 0.0047
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0142 0.0525
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0126 0.0452
Trypanosoma brucei trypanothione reductase 0.0048 0.0071 0.0719
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0043 0.102
Toxoplasma gondii thioredoxin reductase 0.0048 0.0071 0.0664
Entamoeba histolytica cysteine proteinase, putative 0.0325 0.0613 0.532
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0024
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0118 0.0208 0.2258
Brugia malayi CXXC zinc finger family protein 0.0035 0.0045 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0023 0.0234
Onchocerca volvulus 0.01 0.0172 0.0167
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0126 0.0452
Loa Loa (eye worm) hypothetical protein 0.0052 0.0079 0.0079
Entamoeba histolytica cysteine protease, putative 0.0118 0.0208 0.1789
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0079 0.0805
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0039 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0208 0.1938
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0466 0.0888 0.8371
Loa Loa (eye worm) hypothetical protein 0.0055 0.0084 0.0084
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0191 0.1332
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0023 0.0176
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0112 0.0195 0.0195
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0039 0.0145
Giardia lamblia Cathepsin B precursor 0.0118 0.0208 0.205
Giardia lamblia PHD finger protein 15 0.006 0.0095 0.0885
Loa Loa (eye worm) hypothetical protein 0.0599 0.1149 0.1149
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0071 0.0262
Schistosoma mansoni lamin 0.0055 0.0084 0.0292
Plasmodium falciparum thioredoxin reductase 0.0048 0.0071 0.0697
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0051 0.0172
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.001 0.0036
Brugia malayi AF-10 protein 0.002 0.0015 0.0015
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0039 0.0145
Plasmodium falciparum phd finger protein, putative 0.006 0.0095 0.0975
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0178 0.1659
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.0339 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0259 0.0484 0.1785
Entamoeba histolytica hypothetical protein 0.0036 0.0048 0.0395
Giardia lamblia Cathepsin B precursor 0.0118 0.0208 0.205
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0023 0.0176
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0025 0.0118
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0123 0.0438
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0122 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.001 0.001
Onchocerca volvulus 0.0112 0.0195 0.019
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0015 0.0064
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0043 0.0383
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0108 0.1044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0054 0.019
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0039 0.0034
Loa Loa (eye worm) G protein alpha subunit 3 0.0014 0.0005 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0333 0.0629 0.0994
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0019 0.0105
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0023 0.3111
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0023 0.0023
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0009 0.0067
Mycobacterium ulcerans hypothetical protein 0.0025 0.0025 0.0487
Chlamydia trachomatis pyruvate kinase 0.0034 0.0043 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0039 0.0062
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0052 0.0462
Brugia malayi jmjC domain containing protein 0.002 0.0015 0.0014
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0141 0.0253 0.0253
Plasmodium vivax serine-repeat antigen (SERA) 0.0118 0.0208 0.2258
Onchocerca volvulus Huntingtin homolog 0.0126 0.0223 0.0218
Schistosoma mansoni cpg binding protein 0.0037 0.0049 0.0162
Echinococcus multilocularis pyruvate kinase 0.0017 0.0011 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0024
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0006 0.0001
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0106 0.0184 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.0208 0.1938
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0333 0.0629 0.2332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0024
Brugia malayi PHD-finger family protein 0.006 0.0095 0.0094
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0026
Echinococcus granulosus cathepsin l1 0.0325 0.0613 0.227
Mycobacterium leprae conserved hypothetical protein 0.0112 0.0195 0.8976
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0118 0.0208 0.1938
Echinococcus multilocularis jumonji domain containing protein 0.0084 0.0141 0.0223
Loa Loa (eye worm) hypothetical protein 0.0126 0.0223 0.0223
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.0195 0.5625
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.001 0.0003
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0043 0.038
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0027 0.0026
Giardia lamblia Kinase, PLK 0.0103 0.0178 0.1745
Echinococcus multilocularis snurportin 1 0.0372 0.0704 0.1112
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0006 0.0005
Brugia malayi nuclear receptor NHR-88 0.0032 0.0039 0.0038
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.0178 0.18
Onchocerca volvulus Cathepsin F homolog 0.0466 0.0888 0.0884
Onchocerca volvulus 0.0466 0.0888 0.0884
Brugia malayi MH2 domain containing protein 0.0144 0.0259 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0191 0.1332
Loa Loa (eye worm) cysteine protease 0.0466 0.0888 0.0888
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0466 0.0888 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0079 0.0793
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0039 0.0062
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0034 0.0126
Giardia lamblia Cathepsin B precursor 0.0118 0.0208 0.205
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0005 0.0019
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0025 0.0214
Giardia lamblia Cathepsin L precursor 0.0118 0.0208 0.205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.0208 0.1938
Plasmodium vivax JmjC domain containing protein 0.002 0.0015 0.0064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0195 0.0706
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0035 0.011
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0052 0.0427
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0023 0.0102
Plasmodium vivax importin-beta 2, putative 0.0035 0.0045 0.0405
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.002 0.0117
Loa Loa (eye worm) IKK protein kinase 0.5124 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0005 0.0018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.0391 0.0391
Schistosoma mansoni loxhd1 0.0021 0.0019 0.0051
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0015 0.0045
Leishmania major trypanothione reductase 0.0048 0.0071 0.0695
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0118 0.0208 0.205
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0253
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0043 0.0247
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.0688 0.6477
Mycobacterium tuberculosis Conserved protein 0.0112 0.0195 0.1364
Onchocerca volvulus 0.0147 0.0265 0.026
Echinococcus granulosus importin subunit beta 1 0.0035 0.0045 0.0167
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0071 0.0071
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.0124 0.0459
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0005 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.0688 0.6477
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0052 0.0462
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0014 0.0005 0.0008
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0015 0.0039
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0038 0.0038
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0198 0.0364 0.1349
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0015 0.0092
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0014 0.0005 0.0004
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0512 0.0978 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0118 0.0208 0.2258
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0092
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0095 0.0095
Giardia lamblia Encystation-specific protease 0.0118 0.0208 0.205
Onchocerca volvulus Huntingtin homolog 0.0126 0.0223 0.0218
Schistosoma mansoni coup transcription factor 0.0032 0.0039 0.0127
Brugia malayi Cathepsin L-like precursor 0.0466 0.0888 0.0888
Toxoplasma gondii cathepsin CPC2 0.0118 0.0208 0.2076
Giardia lamblia Cathepsin L precursor 0.0118 0.0208 0.205
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0019 0.0069
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0084 0.0084
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.0195 0.1364
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0039 0.0062
Trypanosoma cruzi cysteine peptidase, putative 0.0466 0.0888 0.3286
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0036 0.0048 0.0395
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0466 0.0888 0.9084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Brugia malayi Cathepsin L-like precursor 0.0466 0.0888 0.0888
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0128 0.0227 0.084
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0025 0.0094
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0043 0.038
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0198 0.0364 0.0575
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0009 0.0092
Schistosoma mansoni cathepsin F (C01 family) 0.0325 0.0613 0.2257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Giardia lamblia Cathepsin B precursor 0.0512 0.0978 1
Echinococcus multilocularis cathepsin b 0.1391 0.2698 0.4263
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.0178 0.0174
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0027 0.009
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0011 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0466 0.0888 0.8371
Plasmodium falciparum pyruvate kinase 0.0034 0.0043 0.0383
Loa Loa (eye worm) hypothetical protein 0.0126 0.0223 0.0223
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0009 0.0024
Onchocerca volvulus 0.0466 0.0888 0.0884
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0045 0.0071
Onchocerca volvulus 0.0466 0.0888 0.0884
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.0399 0.1469
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0195 0.1817
Entamoeba histolytica cysteine protease, putative 0.0118 0.0208 0.1789
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0023 0.042
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0052 0.0462
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0038 0.0059
Brugia malayi beta-lactamase family protein 0.0112 0.0195 0.0194
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1391 0.2698 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0052 0.0462
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.001 0.0094
Brugia malayi Cathepsin L-like cysteine proteinase 0.0325 0.0613 0.0612
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0054 0.0524
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.0314 0.0314
Giardia lamblia Cathepsin L precursor 0.0118 0.0208 0.205
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0185 0.0339 0.3452
Trypanosoma cruzi cruzipain precursor, putative 0.0466 0.0888 0.3286
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0005
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0005 0.0018
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0043 0.038
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0084 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0195 0.0706
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0512 0.0978 0.3618
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0051 0.005
Onchocerca volvulus 0.0112 0.0195 0.019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0084 0.0084
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0054 0.0085
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0054 0.019
Plasmodium vivax vivapain-2 0.0466 0.0888 1
Giardia lamblia Cathepsin L precursor 0.0118 0.0208 0.205
Brugia malayi Papain family cysteine protease containing protein 0.0118 0.0208 0.0207
Loa Loa (eye worm) hypothetical protein 0.0141 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0325 0.0613 0.0613
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0015 0.015
Trypanosoma brucei polo-like protein kinase 0.0103 0.0178 0.182
Leishmania major hypothetical protein, conserved 0.002 0.0015 0.0125
Echinococcus granulosus peregrin 0.006 0.0095 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0208 0.1938
Trypanosoma cruzi cysteine protease, putative 0.0259 0.0484 0.1785
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0025 0.0084
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0185 0.0339 0.0536
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.001 0.0018
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.002 0.0117
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0122 0.1188
Brugia malayi cathepsin L precursor 0.0118 0.0208 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0118 0.0208 0.1938
Echinococcus multilocularis pyruvate kinase 0.0017 0.0011 0.0017
Loa Loa (eye worm) hypothetical protein 0.0466 0.0888 0.0888
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0015 0.0154
Echinococcus granulosus jumonji domain containing protein 0.0084 0.0141 0.0524
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0005 0.0018
Brugia malayi cathepsin F-like cysteine proteinase 0.0118 0.0208 0.0207
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0333 0.0629 0.0629
Echinococcus multilocularis peregrin 0.006 0.0095 0.015
Loa Loa (eye worm) cathepsin B 0.0512 0.0978 0.0978
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0039 0.0038
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0122 0.1036
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.0314 0.0314
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.0178 0.0282
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0023 0.0036
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0034 0.0034
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0713 0.1371 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0039
Echinococcus multilocularis cathepsin L cysteine protease 0.0466 0.0888 0.1404
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0435 0.0435
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0015 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0191 0.1332
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.1061 1
Plasmodium vivax unspecified product 0.0141 0.0253 0.2769
Echinococcus granulosus snurportin 1 0.0372 0.0704 0.261
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0011 0.0017
Trichomonas vaginalis ran, putative 0.0026 0.0027 0.0228
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0118 0.0208 0.0754
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0014 0.0005 0.0018
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0118 0.0208 0.0754
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0014 0.0005 0.0004
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0106 0.0184 0.029
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0126 0.0452
Schistosoma mansoni cathepsin s 0.0141 0.0253 0.0921
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.0195 0.1364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0039 0.0039
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.0115 0.1057
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0039
Brugia malayi Cathepsin L-like precursor 0.0325 0.0613 0.0612
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0178 0.1659
Echinococcus granulosus lamin 0.0055 0.0084 0.031
Schistosoma mansoni hypothetical protein 0.0494 0.0943 0.3484
Loa Loa (eye worm) jmjC domain-containing protein 0.0125 0.0221 0.0221
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.0178 0.1531
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.001 0.0036
Trypanosoma brucei cysteine peptidase C (CPC) 0.0512 0.0978 1
Echinococcus granulosus pyruvate kinase 0.0034 0.0043 0.0159
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0051
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0314 0.0497
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.0195 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0028
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0014 0.0005 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0009 0.0024
Brugia malayi jmjC domain containing protein 0.002 0.0015 0.0014
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0027 0.0272
Brugia malayi cathepsin L-like precursor 0.0325 0.0613 0.0612
Brugia malayi nuclear hormone receptor 0.0032 0.0039 0.0038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0054 0.0508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0466 0.0888 0.9084
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0052 0.0051
Leishmania major GTP-binding protein, putative 0.0026 0.0027 0.0248
Trypanosoma cruzi cruzipain precursor, putative 0.0141 0.0253 0.0927
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.0178 0.0178
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0005 0.0008
Schistosoma mansoni phd/f-box containing protein 0.002 0.0015 0.0038
Schistosoma mansoni lipoxygenase 0.0089 0.0151 0.0544
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0054 0.0483
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0466 0.0888 0.8371
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0006 0.0005
Brugia malayi Cathepsin L-like precursor 0.0466 0.0888 0.0888
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0043 0.0038
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0025 0.0487
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0512 0.0978 0.3613
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0039 0.0062
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0032 0.0276
Brugia malayi beta-lactamase family protein 0.0112 0.0195 0.0194
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0051 0.0179
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0184 0.0663
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0122 0.1122
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0141 0.0253 0.0252
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.001 0.0069
Entamoeba histolytica cysteine protease, putative 0.0118 0.0208 0.1789
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0015 0.0015
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0122 0.1122
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0195 0.0713
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Loa Loa (eye worm) hypothetical protein 0.0118 0.0208 0.0208
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Brugia malayi Cathepsin L-like precursor 0.0466 0.0888 0.0888
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.0195 0.0723
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0195 0.1817
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0704 0.0704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0466 0.0888 0.9084
Toxoplasma gondii preprocathepsin c precursor, putative 0.0118 0.0208 0.2076
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0015
Echinococcus multilocularis lysine specific demethylase 5A 0.0073 0.012 0.019
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0015 0.0097
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0027 0.009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0126 0.0126
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0011 0.004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0039 0.0038
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.001 0.001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0466 0.0888 0.1404
Loa Loa (eye worm) hypothetical protein 0.0032 0.0039 0.0039
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.001 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0006 0.001
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0009 0.0092
Loa Loa (eye worm) hypothetical protein 0.0118 0.0208 0.0208
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0006 0.0005
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0009 0.0024
Brugia malayi Papain family cysteine protease containing protein 0.0259 0.0484 0.0483
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.001 0.0015
Echinococcus multilocularis cathepsin b 0.1391 0.2698 0.4263
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0006 0.001
Schistosoma mansoni cathepsin F (C01 family) 0.0466 0.0888 0.3281
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0039 0.0127
Giardia lamblia Pyruvate kinase 0.0034 0.0043 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.0208 0.1938
Brugia malayi beta-lactamase 0.0112 0.0195 0.0194
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0118 0.0208 0.2258
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.0195 0.1364
Leishmania major hypothetical protein, conserved 0.0112 0.0195 0.1971
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0025 0.0232
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0036 0.0048 0.0161
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0039 0.0062
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0015 0.0045
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0034 0.0043 0.0043
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0051 0.0081
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0071 0.0252
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0118 0.0208 0.0208
Entamoeba histolytica cysteine proteinase, putative 0.0466 0.0888 0.7728
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0025 0.0084
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0019 0.003
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.0484 0.4197
Toxoplasma gondii ABC1 family protein 0.0112 0.0195 0.1944
Onchocerca volvulus Alhambra homolog 0.006 0.0095 0.009
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0039 0.0038
Mycobacterium tuberculosis Conserved protein 0.0025 0.0025 0.0118
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.001 0.0015
Plasmodium vivax vivapain-3 0.0259 0.0484 0.5397
Schistosoma mansoni cpg binding protein 0.0037 0.0049 0.0162
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0023 0.0176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0038 0.0121
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0027 0.0201
Plasmodium vivax vivapain-2 0.0466 0.0888 1
Plasmodium falciparum glutathione reductase 0.0048 0.0071 0.0697
Entamoeba histolytica cysteine protease, putative 0.0466 0.0888 0.7728
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0005
Plasmodium vivax SET domain protein, putative 0.0031 0.0038 0.0321
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0023 0.0158
Echinococcus multilocularis cathepsin L 0.0118 0.0208 0.0328
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0025 0.0214
Brugia malayi conserved hypotetical protein 0.0015 0.0006 0.0005
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0126 0.02
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0195 0.1817
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.0688 0.6477
Loa Loa (eye worm) hypothetical protein 0.0118 0.0208 0.0208
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0142 0.0508
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Brugia malayi Doublecortin family protein 0.0021 0.0019 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0195 0.1817
Brugia malayi jmjC domain containing protein 0.002 0.0015 0.0014
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0054 0.3976
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0009 0.0062
Leishmania major cathepsin L-like protease 0.0466 0.0888 0.9082
Echinococcus granulosus cathepsin l cysteine peptidase 0.0466 0.0888 0.3293
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0118 0.0208 0.0754
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0005
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0118 0.0208 0.2258
Mycobacterium ulcerans hypothetical protein 0.0025 0.0025 0.0487
Toxoplasma gondii cathepsin B 0.0512 0.0978 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0259 0.0484 0.1778
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0092
Brugia malayi hypothetical protein 0.0015 0.0006 0.0005
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0022
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0178 0.0651
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0259 0.0259
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0051 0.0081
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.001 0.0036
Brugia malayi Melibiase family protein 0.007 0.0115 0.0114
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0015 0.0056
Brugia malayi nuclear receptor RXR 0.0015 0.0006 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.0339 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0466 0.0888 0.8371
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0039 0.0145
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0014 0.0005 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0216 0.0399 0.1469
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0118 0.0208 0.1938
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0067
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0032 0.0276
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0006 0.0001
Brugia malayi ecdysone receptor 0.0015 0.0006 0.0005
Plasmodium falciparum serine repeat antigen 7 0.0118 0.0208 0.2258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0259 0.0484 0.4945
Echinococcus multilocularis pyruvate kinase 0.0034 0.0043 0.0068
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0009 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0466 0.0888 0.9084
Loa Loa (eye worm) glutathione reductase 0.0048 0.0071 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0006 0.0005
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.001 0.0025
Entamoeba histolytica cysteine protease, putative 0.0259 0.0484 0.4197
Echinococcus multilocularis expressed protein 0.0014 0.0005 0.0008
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0015 0.0024
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0005 0.0018
Onchocerca volvulus 0.0084 0.0142 0.0137
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0009 0.0033
Giardia lamblia Hypothetical protein 0.0118 0.0208 0.205
Echinococcus multilocularis phd:f box containing protein 0.002 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0011
Giardia lamblia Pyruvate kinase 0.0017 0.0011 0.0015
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0019 0.0069
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0014 0.0005 0.0019
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0043 0.0043
Mycobacterium tuberculosis Conserved protein 0.0112 0.0195 0.1364
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.0484 0.4197
Brugia malayi Papain family cysteine protease containing protein 0.0118 0.0208 0.0207
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0259 0.0484 0.1778
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.0339 1
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0122 0.0451
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.1061 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0259 0.0259
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0039 0.0145
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0006
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.001 0.0025
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0054 0.0328
Trypanosoma cruzi cysteine peptidase, putative 0.0259 0.0484 0.1785
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0052 0.0182
Schistosoma mansoni hypothetical protein 0.0372 0.0704 0.2596
Schistosoma mansoni nuclear receptor 0.0015 0.0006 0.0005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0011 0.004
Plasmodium falciparum serine repeat antigen 1 0.0118 0.0208 0.2258
Leishmania major cathepsin L-like protease 0.0466 0.0888 0.9082
Schistosoma mansoni kinase 0.0055 0.0084 0.0295
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0095 0.0916
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0118 0.0208 0.2258
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0051 0.0456
Echinococcus granulosus cathepsin L cysteine protease 0.0259 0.0484 0.1793
Loa Loa (eye worm) hypothetical protein 0.0112 0.0195 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.0484 0.4546
Schistosoma mansoni jumonji domain containing protein 0.002 0.0015 0.0038
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0039 0.0039
Echinococcus granulosus cathepsin l1 0.0466 0.0888 0.3293
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0051 0.0189
Schistosoma mansoni lamin 0.0055 0.0084 0.0292
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0011 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0325 0.0613 0.5763
Giardia lamblia Cathepsin L precursor 0.0118 0.0208 0.205
Echinococcus granulosus intermediate filament protein 0.0055 0.0084 0.031
Echinococcus multilocularis lamin 0.0055 0.0084 0.0132
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0011 0.001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0191 0.8753
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0009 0.0062
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0191 0.1332
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0466 0.0888 0.8371
Schistosoma mansoni hypothetical protein 0.0017 0.0011 0.0022
Brugia malayi jmjC domain containing protein 0.002 0.0015 0.0014
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0039 0.0127
Onchocerca volvulus 0.0015 0.0006 0.0001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0122 0.1122
Brugia malayi tailless protein 0.0015 0.0006 0.0005
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0052 0.0427
Echinococcus granulosus cathepsin L cysteine proteinase 0.0466 0.0888 0.3293
Plasmodium vivax unspecified product 0.0118 0.0208 0.2258
Schistosoma mansoni alpha glucosidase 0.0038 0.0052 0.0174
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0005 0.0017
Brugia malayi Cathepsin L-like precursor 0.0466 0.0888 0.0888
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0314 0.0497
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0118 0.0208 0.2258
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0124 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.0726 0.6839
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0045 0.0456
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0039 0.0127
Toxoplasma gondii exonuclease III APE 0.0039 0.0054 0.0492
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0023 0.0158
Echinococcus multilocularis RUN 0.0021 0.0019 0.0029
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0325 0.0613 0.2262
Leishmania major cathepsin L-like protease 0.0466 0.0888 0.9082
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0122 0.0441
Echinococcus multilocularis cathepsin L 0.0259 0.0484 0.0764
Plasmodium vivax hypothetical protein, conserved 0.0022 0.002 0.0117
Brugia malayi fibroinase precursor 0.0118 0.0208 0.0207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0512 0.0978 0.9217
Mycobacterium leprae Probable lipase LipE 0.0112 0.0195 0.8976
Schistosoma mansoni inositol monophosphatase 0.0074 0.0122 0.0433
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.0195 0.0308
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1391 0.2698 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0466 0.0888 0.9084
Leishmania major cathepsin L-like protease 0.0466 0.0888 0.9082
Plasmodium falciparum cysteine proteinase falcipain 1 0.0259 0.0484 0.5397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0466 0.0888 0.8371
Entamoeba histolytica cysteine proteinase, putative 0.0466 0.0888 0.7728
Schistosoma mansoni nuclear receptor 0.0015 0.0006 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0259 0.0484 0.4945

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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