Detailed information for compound 156509

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 475.535 | Formula: C24H33N3O7
  • H donors: 3 H acceptors: 5 LogP: 0.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1C[C@@H](OCCOC(=O)c2cnc3c(n2)cccc3)CC(C1O[C@H]1CC(N)C(C(O1)C)O)O
  • InChi: 1S/C24H33N3O7/c1-13-9-15(10-20(28)23(13)34-21-11-16(25)22(29)14(2)33-21)31-7-8-32-24(30)19-12-26-17-5-3-4-6-18(17)27-19/h3-6,12-16,20-23,28-29H,7-11,25H2,1-2H3/t13?,14?,15-,16?,20?,21+,22?,23?/m1/s1
  • InChiKey: OZYQBWZSASTTJH-LJEYZORSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0162 0.0153
Echinococcus granulosus lamin 0.003 0.0018 0.0017
Echinococcus granulosus intermediate filament protein 0.003 0.0018 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0016 0.0009
Mycobacterium tuberculosis Probable hydrolase 0.0029 0.0016 0.011
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6329 1 1
Schistosoma mansoni hypothetical protein 0.0062 0.0068 0.0068
Brugia malayi hypothetical protein 0.0264 0.0388 0.0388
Schistosoma mansoni tar DNA-binding protein 0.006 0.0065 0.0065
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.0117 0.0116
Echinococcus multilocularis beta LACTamase domain containing family member 0.0029 0.0016 0.0015
Onchocerca volvulus 0.003 0.0018 0.027
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.006 0.006
Leishmania major phosphatidylinositol kinase, putative 0.042 0.0635 0.0634
Echinococcus granulosus cation transporting atpase worm 0.0025 0.0009 0.0008
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0121 0.0162 0.0161
Trichomonas vaginalis fk506-binding protein, putative 0.0121 0.0162 0.0155
Trichomonas vaginalis esterase, putative 0.0029 0.0016 0.0009
Brugia malayi Cyclic-nucleotide gated cation channel 0.0023 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.4719 0.7449 0.7447
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0044 0.0638
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0025 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2209 0.3472 0.3471
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0486 0.074 0.0732
Trichomonas vaginalis PIKK family atypical protein kinase 0.3783 0.5965 0.5962
Echinococcus multilocularis phosphoserine phosphatase 0.0025 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.3434 0.5412 0.5408
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0074 0.0087 0.0086
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0025 0.0009 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0078 0.0094 0.0094
Schistosoma mansoni voltage-gated potassium channel 0.013 0.0176 0.0176
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0051 0.005
Schistosoma mansoni hypothetical protein 0.0029 0.0016 0.0016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0062 0.0068 0.0068
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0823 0.1274 0.1274
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0008
Entamoeba histolytica hypothetical protein 0.0026 0.0012 0.0002
Toxoplasma gondii FATC domain-containing protein 0.1217 0.1899 0.2549
Loa Loa (eye worm) beta-lactamase 0.0029 0.0016 0.0015
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0486 0.074 0.0733
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0033 0.0023 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2641 0.4156 0.415
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0121 0.0162 0.0153
Echinococcus multilocularis GPCR, family 2 0.0074 0.0087 0.0086
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.006 0.006
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0025 0.0009 0.0008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0016 0.0016
Plasmodium vivax ataxin-2 like protein, putative 0.0046 0.0044 0.0638
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0823 0.1274 0.1274
Trichomonas vaginalis PIKK family atypical protein kinase 0.2153 0.3383 0.3378
Brugia malayi E1-E2 ATPase family protein 0.0025 0.0009 0.0008
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6329 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0486 0.074 0.0732
Echinococcus multilocularis survival motor neuron protein 1 0.0264 0.0388 0.0388
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0078 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Trichomonas vaginalis cation-transporting ATPase, putative 0.0025 0.0009 0.0002
Echinococcus multilocularis lamin 0.003 0.0018 0.0017
Echinococcus multilocularis phosphoserine phosphatase 0.0025 0.0009 0.0008
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0153 0.2302
Schistosoma mansoni cpg binding protein 0.0052 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0008
Brugia malayi hypothetical protein 0.0256 0.0376 0.0375
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.042 0.0635 0.0634
Schistosoma mansoni tar DNA-binding protein 0.006 0.0065 0.0065
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0025 0.0009 0.0009
Giardia lamblia GTOR 0.6329 1 1
Brugia malayi Muscle positioning protein 4 0.0029 0.0016 0.0015
Schistosoma mansoni immunophilin 0.0121 0.0162 0.0162
Echinococcus multilocularis 0.042 0.0635 0.0634
Schistosoma mansoni cation-transporting atpase worm 0.0025 0.0009 0.0009
Trypanosoma brucei trypanothione reductase 0.0051 0.0051 0.0041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0074 0.0087 0.0086
Brugia malayi RNA recognition motif domain containing protein 0.006 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0103 0.0134 0.0133
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0008 0.0008
Mycobacterium tuberculosis Conserved protein 0.0029 0.0016 0.011
Loa Loa (eye worm) glutathione reductase 0.0051 0.0051 0.005
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0029 0.0016 0.011
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0441 0.067 0.0661
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0631 0.097 0.0969
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0003 0.0002
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.042 0.0635 0.0634
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0078 0.0094 0.0094
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0029 0.0016 0.0015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0051 0.005
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0441 0.067 0.0663
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.5393 0.8516 0.8515
Mycobacterium tuberculosis Probable esterase LipL 0.0029 0.0016 0.011
Brugia malayi RNA binding protein 0.006 0.0065 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0236 0.0344 0.0343
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0025 0.0009 0.0124
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0441 0.067 0.0898
Trichomonas vaginalis PIKK family atypical protein kinase 0.5044 0.7963 0.7961
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0441 0.067 0.0661
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.006 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0635 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.1229 0.1918 0.1912
Trichomonas vaginalis PIKK family atypical protein kinase 0.3439 0.542 0.5417
Trichomonas vaginalis PIKK family atypical protein kinase 0.4719 0.7449 0.7447
Trichomonas vaginalis conserved hypothetical protein 0.0798 0.1235 0.1228
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0174 0.2628
Onchocerca volvulus 0.0029 0.0016 0.0234
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1337 0.209 0.2089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0798 0.1235 0.1228
Trichomonas vaginalis cation-transporting ATPase, putative 0.0025 0.0009 0.0002
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0631 0.097 0.0963
Loa Loa (eye worm) hypothetical protein 0.0256 0.0376 0.0375
Leishmania major fk506-binding protein 1-like protein 0.0121 0.0162 0.0161
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0016 0.0009
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.006 0.006
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0153 0.2302
Loa Loa (eye worm) hypothetical protein 0.0077 0.0092 0.0091
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.006 0.006
Trichomonas vaginalis immunophilin, putative 0.0121 0.0162 0.0155
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1217 0.1899 0.1899
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0119 0.0158 0.0158
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0218 0.0316 0.0315
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0051 0.005
Onchocerca volvulus 0.0025 0.0009 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.2153 0.3383 0.3378
Loa Loa (eye worm) hypothetical protein 0.0162 0.0227 0.0226
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0174 0.2628
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0121 0.0162 0.0161
Schistosoma mansoni hypothetical protein 0.0353 0.053 0.053
Loa Loa (eye worm) hypothetical protein 0.0554 0.0849 0.0848
Mycobacterium tuberculosis Conserved hypothetical protein 0.042 0.0635 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0012 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0078 0.0094 0.0094
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.006 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.1356 0.2119 0.2113
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0023 0.0008 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0016 0.0227
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0119 0.0158 0.0158
Loa Loa (eye worm) phosphatidylinositol 3 0.042 0.0635 0.0634
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.006 0.006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0112 0.0147 0.0146
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0025 0.0009 0.0008
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6329 1 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.006 0.006
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1217 0.1899 0.1892
Brugia malayi E1-E2 ATPase family protein 0.0025 0.0009 0.0008
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2209 0.3472 0.3471
Entamoeba histolytica protein kinase rad3, putative 0.1217 0.1899 0.1892
Schistosoma mansoni fkbp-rapamycin associated protein 0.1217 0.1899 0.1899
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0704 0.1087 0.1086
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0074 0.0087 0.0086
Brugia malayi latrophilin 2 splice variant baaae 0.0159 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0104 0.0136 0.0135
Loa Loa (eye worm) phosphatidylinositol 3 0.042 0.0635 0.0634
Loa Loa (eye worm) phosphatidylinositol 3 0.6329 1 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.042 0.0635 0.948
Schistosoma mansoni intermediate filament proteins 0.003 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.0046 0.0044 0.0043
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0174 0.2628
Trichomonas vaginalis PIKK family atypical protein kinase 0.3783 0.5965 0.5962
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.006 0.006
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0936 0.1454 0.1453
Loa Loa (eye worm) phosphatidylinositol 3 0.0066 0.0076 0.0075
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.006 0.0053
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0486 0.074 0.0733
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0012 0.004
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0025 0.0009 0.0008
Echinococcus multilocularis cation transporting ATPase 13A3 0.0025 0.0009 0.0008
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0236 0.0344 0.0335
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.042 0.0635 0.0852
Trichomonas vaginalis PIKK family atypical protein kinase 0.3763 0.5934 0.5931
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0631 0.097 0.0969
Loa Loa (eye worm) hypothetical protein 0.0232 0.0339 0.0338
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0012 0.0014
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0066 0.0076 0.0075
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0025 0.0009 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0236 0.0344 0.0343
Echinococcus granulosus tar DNA binding protein 0.006 0.0065 0.0064
Loa Loa (eye worm) TAR-binding protein 0.006 0.0065 0.0064
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0008 0.0007
Schistosoma mansoni lamin 0.003 0.0018 0.0018
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.042 0.0635 0.0627
Entamoeba histolytica hypothetical protein 0.042 0.0635 0.0627
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0025 0.0009 0.0008
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0936 0.1454 0.1453
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.006 0.006
Schistosoma mansoni tar DNA-binding protein 0.006 0.0065 0.0065
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.006 0.006
Schistosoma mansoni type V p-type atpase isoform 0.0025 0.0009 0.0009
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.042 0.0635 0.0635
Echinococcus granulosus lamin dm0 0.003 0.0018 0.0017
Mycobacterium leprae Probable lipase LipE 0.0029 0.0016 0.011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0074 0.0087 0.0087
Mycobacterium tuberculosis Probable reductase 0.0115 0.0153 0.2302
Loa Loa (eye worm) hypothetical protein 0.042 0.0635 0.0634
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0012 0.0161
Leishmania major hypothetical protein, conserved 0.0029 0.0016 0.0015
Echinococcus multilocularis phosphoserine phosphatase 0.0025 0.0009 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0012 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.4719 0.7449 0.7447
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6329 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.006 0.008
Schistosoma mansoni microtubule-associated protein tau 0.0653 0.1005 0.1005
Brugia malayi intermediate filament protein 0.003 0.0018 0.0017
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0631 0.097 0.0969
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0008 0.0007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0184 0.0262 0.4046
Loa Loa (eye worm) phosphatidylinositol kinase 0.042 0.0635 0.0634
Trichomonas vaginalis cation-transporting ATPase, putative 0.0025 0.0009 0.0002
Mycobacterium ulcerans esterase/lipase LipP 0.0029 0.0016 0.0434
Leishmania major P-type H -ATPase, putative 0.0025 0.0009 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.006 0.0053
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0232 0.0339 0.0338
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0025 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.128 0.1999 0.1998
Plasmodium falciparum glutathione reductase 0.0051 0.0051 0.0742
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0008 0.0008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0029 0.0016 0.0434
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0121 0.0162 0.0155
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0153 0.2302
Toxoplasma gondii cation-transporting atpase family protein 0.0025 0.0009 0.0011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0232 0.0339 0.0338
Brugia malayi Latrophilin receptor protein 2 0.0074 0.0087 0.0086
Schistosoma mansoni lamin 0.003 0.0018 0.0018
Trypanosoma cruzi cation-transporting ATPase, putative 0.0025 0.0009 0.0008
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0025 0.0009 0.0002
Brugia malayi MH2 domain containing protein 0.0128 0.0173 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.4719 0.7449 0.7447
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0008
Loa Loa (eye worm) phosphatidylinositol 3 0.0778 0.1204 0.1203
Toxoplasma gondii hypothetical protein 0.0038 0.0031 0.004
Loa Loa (eye worm) hypothetical protein 0.003 0.0017 0.0016
Trypanosoma brucei protein kinase, putative 0.0057 0.006 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.3434 0.5412 0.5408
Loa Loa (eye worm) hypothetical protein 0.0264 0.0388 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.3439 0.542 0.5417
Mycobacterium leprae conserved hypothetical protein 0.042 0.0635 1
Schistosoma mansoni immunophilin 0.0104 0.0136 0.0136
Toxoplasma gondii P-type ATPase4, putative 0.0025 0.0009 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0078 0.0094 0.0094
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1217 0.1899 0.1899
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2165 0.3402 0.3401
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0441 0.067 0.0661
Trichomonas vaginalis PIKK family atypical protein kinase 0.5044 0.7963 0.7961
Plasmodium vivax glutathione reductase, putative 0.0051 0.0051 0.0742
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0016 0.0009
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0121 0.0162 0.0153
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0586 0.09 0.0891
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0008 0.0007
Loa Loa (eye worm) DOMON domain-containing protein 0.0029 0.0016 0.0015
Mycobacterium tuberculosis Conserved protein 0.0029 0.0016 0.011
Loa Loa (eye worm) RNA binding protein 0.006 0.0065 0.0064
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0025 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.2165 0.3402 0.3397
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0012 0.0157
Loa Loa (eye worm) FKBP5 protein 0.0121 0.0162 0.0161
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0486 0.074 0.0733
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0025 0.0009 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.042 0.0635 0.0627
Echinococcus multilocularis voltage gated potassium channel 0.0034 0.0025 0.0024
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6329 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.042 0.0635 0.0634
Schistosoma mansoni ATPase 0.0025 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0159 0.0222 0.0222
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0441 0.067 0.0669
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0025 0.0009 0.0011
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0112 0.0147 0.0146
Loa Loa (eye worm) intermediate filament protein 0.003 0.0018 0.0017
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0025 0.0009 0.0002
Mycobacterium ulcerans lipase LipD 0.0029 0.0016 0.0434
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0074 0.0087 0.0086
Schistosoma mansoni survival motor neuron protein 0.0054 0.0056 0.0056
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0441 0.067 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0008 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.042 0.0635 0.0634
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0051 0.0742
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0025 0.0009 0.0002
Leishmania major trypanothione reductase 0.0051 0.0051 0.005
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0121 0.0162 1
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0016 0.0015
Leishmania major hypothetical protein, conserved 0.0521 0.0795 0.0794
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0018 0.0017
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6329 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.3783 0.5965 0.5962
Toxoplasma gondii P-type ATPase PMA1 0.0025 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0034 0.0033
Schistosoma mansoni tar DNA-binding protein 0.006 0.0065 0.0065
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6329 1 1
Trypanosoma cruzi proton motive ATPase 1, putative 0.0025 0.0009 0.0008
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0586 0.09 0.0891
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0111 0.0146 0.0139
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0025 0.0024
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0012 1
Onchocerca volvulus 0.0162 0.0227 0.356
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0111 0.0146 0.0139
Plasmodium falciparum phosphatidylinositol 4-kinase 0.042 0.0635 0.948
Trichomonas vaginalis PIKK family atypical protein kinase 0.6329 1 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0025 0.0009 0.0002
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0121 0.0162 0.0153
Brugia malayi hypothetical protein 0.0162 0.0227 0.0226
Brugia malayi Thioredoxin reductase 0.0051 0.0051 0.005
Leishmania major calcium-translocating P-type ATPase 0.0025 0.0009 0.0008
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0162 0.0161
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0441 0.067 0.0669
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0023 0.0008 0.0007
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0025 0.0009 0.0008
Plasmodium vivax P-type ATPase4, putative 0.0025 0.0009 0.0124
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0631 0.097 0.0962
Echinococcus granulosus cation transporting ATPase 13A1 0.0025 0.0009 0.0008
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.042 0.0635 0.0852
Trichomonas vaginalis PIKK family atypical protein kinase 0.5044 0.7963 0.7961
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.042 0.0635 0.0634
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0121 0.0162 0.2413
Schistosoma mansoni hypothetical protein 0.0074 0.0087 0.0087
Echinococcus multilocularis dnaJ subfamily B 0.0353 0.053 0.0529
Onchocerca volvulus 0.0029 0.0016 0.0239
Echinococcus granulosus voltage gated potassium channel 0.0034 0.0025 0.0024
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0104 0.0136 0.0135
Entamoeba histolytica hypothetical protein 0.042 0.0635 0.0627
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0554 0.0849 0.0848
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0441 0.067 0.0669
Entamoeba histolytica hypothetical protein 0.0062 0.0068 0.0059
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0563 0.0862 0.0855
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0119 0.0158 0.0158
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0025 0.0009 0.0002
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6329 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0078 0.0094 0.0094
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0025 0.0009 0.0008
Onchocerca volvulus 0.0029 0.0016 0.0239
Loa Loa (eye worm) hypothetical protein 0.0256 0.0376 0.0375
Trypanosoma cruzi target of rapamycin kinase 3 0.5049 0.7971 0.7971
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0025 0.0009 0.0002
Schistosoma mansoni hypothetical protein 0.0074 0.0087 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0044 0.0043
Echinococcus multilocularis phosphoserine phosphatase 0.0025 0.0009 0.0008
Echinococcus granulosus serine protein kinase ATM 0.1217 0.1899 0.1899
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0025 0.0025
Loa Loa (eye worm) CXXC zinc finger family protein 0.0052 0.0053 0.0052
Leishmania major phosphatidylinositol kinase related protein, putative 0.042 0.0635 0.0634
Echinococcus multilocularis tar DNA binding protein 0.006 0.0065 0.0064
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.0117 0.0116
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6329 1 1
Mycobacterium tuberculosis Conserved protein 0.0029 0.0016 0.011
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0486 0.074 0.074
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.042 0.0635 0.948
Onchocerca volvulus 0.0093 0.0117 0.1836
Trichomonas vaginalis PIKK family atypical protein kinase 0.1217 0.1899 0.1893
Leishmania major P-type H -ATPase, putative 0.0025 0.0009 0.0008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0029 0.0016 0.011
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.042 0.0635 0.0634
Brugia malayi MAP kinase sur-1 0.0057 0.006 0.006
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0025 0.0009 0.0008
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0025 0.0009 0.0011
Schistosoma mansoni eyes absent homolog 0.0256 0.0376 0.0376
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5049 0.7971 0.7971
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.042 0.0635 0.0634
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0016 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0062 0.0068 0.0068
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0034 0.0025 0.0024
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0056 0.0055
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0025 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.6329 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0121 0.0162 0.0161
Echinococcus multilocularis Zinc finger, PHD finger 0.0441 0.067 0.0669
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0162 0.0161
Schistosoma mansoni ATPase 0.0025 0.0009 0.0009
Plasmodium falciparum copper-transporting ATPase 0.0025 0.0009 0.0124
Loa Loa (eye worm) phosphatidylinositol 3 0.042 0.0635 0.0634
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0029 0.0016 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.2153 0.3383 0.3378
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0441 0.067 0.0669
Schistosoma mansoni mixed-lineage leukemia protein mll 0.011 0.0145 0.0145
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0112 0.0147 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Brugia malayi follicle stimulating hormone receptor 0.0218 0.0316 0.0315
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.042 0.0635 0.948
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0078 0.0094 0.0094
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0034 0.0025 0.0024
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0051 0.005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0074 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0159 0.0222 0.0221
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0153 0.2302
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0441 0.067 0.0898
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0008 0.0007
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0121 0.0162 0.0155
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0074 0.0087 0.0086
Brugia malayi Na,K-ATPase alpha subunit 0.0025 0.0009 0.0008
Echinococcus granulosus copper transporting ATPase 1 0.0025 0.0009 0.0008
Echinococcus granulosus cpg binding protein 0.0055 0.0057 0.0057
Trypanosoma brucei PAB1-binding protein , putative 0.0046 0.0044 0.0034
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0704 0.1087 0.1086
Brugia malayi SEA domain containing protein 0.0029 0.0016 0.0015
Leishmania major hypothetical protein, unknown function 0.042 0.0635 0.0634
Leishmania major copper-transporting ATPase-like protein, putative 0.0025 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0798 0.1235 0.1234
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0121 0.0162 0.0161
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.042 0.0635 0.0634
Leishmania major phosphatidylinositol 3-kinase, putative 0.2153 0.3383 0.3382
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0635 0.0628
Loa Loa (eye worm) hypothetical protein 0.1217 0.1899 0.1899
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.042 0.0635 0.948
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0008
Toxoplasma gondii LsmAD domain-containing protein 0.0046 0.0044 0.0057
Echinococcus multilocularis copper transporting ATPase 1 0.0025 0.0009 0.0008
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.6329 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.2165 0.3402 0.3401
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0464 0.0706 0.0697
Schistosoma mansoni copper ABC transporter ATPase 0.0025 0.0009 0.0009
Trypanosoma cruzi copper-transporting ATPase, putative 0.0025 0.0009 0.0008
Toxoplasma gondii thioredoxin reductase 0.0051 0.0051 0.0067
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.042 0.0635 0.0634
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0441 0.067 0.0669
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0007
Schistosoma mansoni phosphoserine phosphatase 0.0025 0.0009 0.0009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0062 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0062 0.0068 0.0059
Entamoeba histolytica hypothetical protein 0.1217 0.1899 0.1892
Plasmodium falciparum thioredoxin reductase 0.0051 0.0051 0.0742
Schistosoma mansoni atpase class VI type 11c 0.0025 0.0009 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.013 0.013
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0023 0.0022
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0025 0.0009 0.0011
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0003 0.0002
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0823 0.1274 0.1274
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0025 0.0009 0.0009
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.042 0.0635 0.0634
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0119 0.0158 0.0158
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.006 0.006
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0153 0.2302
Trichomonas vaginalis PIKK family atypical protein kinase 0.17 0.2664 0.2658
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0012 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.3763 0.5934 0.5931
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0025 0.0009 0.0008
Brugia malayi glutathione reductase 0.0051 0.0051 0.005
Echinococcus granulosus GPCR family 2 0.0074 0.0087 0.0086
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0046 0.0044 0.0043
Trypanosoma cruzi P-type H+-ATPase, putative 0.0025 0.0009 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0486 0.074 0.0732
Onchocerca volvulus 0.0054 0.0056 0.0863
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0044 0.0043
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0008 0.0008
Onchocerca volvulus 0.003 0.0018 0.027
Mycobacterium tuberculosis Probable lipase LipD 0.0029 0.0016 0.011
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2209 0.3472 0.3471
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0025 0.0009 0.0011
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.0173 0.0172
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1217 0.1899 0.1899
Plasmodium vivax cation transporting ATPase, putative 0.0025 0.0009 0.0124
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0025 0.0009 0.0002
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0162 0.0153
Brugia malayi TAR-binding protein 0.006 0.0065 0.0064
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0012 0.0014
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0025 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0936 0.1454 0.1454
Schistosoma mansoni cation-transporting ATPase 0.0025 0.0009 0.0009
Schistosoma mansoni cpg binding protein 0.0055 0.0057 0.0057
Mycobacterium ulcerans beta-lactamase 0.0029 0.0016 0.0434
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0211 0.0305 0.0296
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0008 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0029 0.0016 0.011
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.042 0.0635 0.0628
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0078 0.0094 0.0094
Brugia malayi hypothetical protein 0.0025 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.3439 0.542 0.5417
Toxoplasma gondii target of rapamycin (TOR), putative 0.4719 0.7449 1
Onchocerca volvulus 0.0029 0.0016 0.0234
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0518 0.0792 0.0783
Echinococcus multilocularis microtubule associated protein 2 0.0653 0.1005 0.1004
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0121 0.0162 0.0161
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0033 0.0023 0.0022
Entamoeba histolytica hypothetical protein 0.042 0.0635 0.0627
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0192 0.0274 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0936 0.1454 0.1447
Leishmania major phosphatidylinositol 3-kinase, putative 0.0441 0.067 0.0669
Schistosoma mansoni cpg binding protein 0.0055 0.0057 0.0057
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0153 0.2302
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0023 0.0008 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0631 0.097 0.0963
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0029 0.0016 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.3434 0.5412 0.5408
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.042 0.0635 0.0628
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0798 0.1235 0.1234
Brugia malayi hypothetical protein 0.003 0.0018 0.0017
Loa Loa (eye worm) E1-E2 ATPase 0.0025 0.0009 0.0008
Loa Loa (eye worm) calcium ATPase 0.0025 0.0009 0.0008
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6329 1 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0121 0.0162 0.0153
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1356 0.2119 0.2843
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.0117 0.0117
Trypanosoma cruzi P-type H+-ATPase, putative 0.0025 0.0009 0.0008
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0936 0.1454 0.1453
Onchocerca volvulus 0.0029 0.0016 0.0234
Echinococcus granulosus microtubule associated protein 2 0.0653 0.1005 0.1004
Loa Loa (eye worm) phosphatidylinositol 3 0.042 0.0635 0.0634
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1229 0.1918 0.1911
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.6699 0.6696
Trichomonas vaginalis PIKK family atypical protein kinase 0.4719 0.7449 0.7447
Giardia lamblia Hypothetical protein 0.042 0.0635 0.0627
Echinococcus granulosus dnaJ subfamily B 0.0353 0.053 0.0529
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0018 0.0017
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0441 0.067 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0441 0.067 0.0669
Onchocerca volvulus 0.0029 0.0016 0.0239
Brugia malayi beta-lactamase family protein 0.0029 0.0016 0.0015
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.006 0.006
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0025 0.0009 0.0011
Echinococcus granulosus beta LACTamase domain containing family member 0.0029 0.0016 0.0015
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.042 0.0635 0.0635
Trichomonas vaginalis PIKK family atypical protein kinase 0.4719 0.7449 0.7447
Trichomonas vaginalis PIKK family atypical protein kinase 0.4719 0.7449 0.7447
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.042 0.0635 0.0634
Schistosoma mansoni immunophilin 0.0121 0.0162 0.0162
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.042 0.0635 0.0634
Echinococcus granulosus cation transporting ATPase 13A3 0.0025 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0054 0.0056 0.0056
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0051 0.066
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0232 0.0339 0.0338
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0025 0.0009 0.0008
Toxoplasma gondii ABC1 family protein 0.0029 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.1356 0.2119 0.2118
Loa Loa (eye worm) hypothetical protein 0.0093 0.0117 0.0116
Schistosoma mansoni phosphatidylinositol 4-kinase 0.042 0.0635 0.0635
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0121 0.0162 0.0162
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0016 0.0016
Mycobacterium ulcerans hypothetical protein 0.0124 0.0167 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.042 0.0635 0.0634
Plasmodium vivax calcium-transporting ATPase, putative 0.0025 0.0009 0.0124
Loa Loa (eye worm) hypothetical protein 0.0025 0.0009 0.0008
Echinococcus multilocularis cation transporting ATPase 13A1 0.0025 0.0009 0.0008
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0104 0.0136 0.0135
Mycobacterium tuberculosis Conserved hypothetical protein 0.0124 0.0167 0.2523
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0025 0.0009 0.0008
Echinococcus multilocularis cpg binding protein 0.0055 0.0057 0.0057
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0631 0.097 0.0963
Echinococcus multilocularis musashi 0.003 0.0018 0.0017
Onchocerca volvulus 0.0052 0.0053 0.0817
Brugia malayi FAT domain containing protein 0.0936 0.1454 0.1453
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.006 0.0053
Loa Loa (eye worm) latrophilin receptor protein 2 0.0074 0.0087 0.0086
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0025 0.0009 0.0011
Plasmodium vivax copper-transporting ATPase, putative 0.0025 0.0009 0.0124
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0023 0.0008 0.0007
Echinococcus granulosus phospholipid transporting ATPase VA 0.0025 0.0009 0.0008
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0025 0.0009 0.0008
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0023 0.0022
Mycobacterium ulcerans hypothetical protein 0.0029 0.0016 0.0434
Leishmania major proton motive ATPase, putative 0.0025 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.042 0.0635 0.0635
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1217 0.1899 0.1899
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0025 0.0009 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0078 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0074 0.0087 0.0087
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0441 0.067 0.0669
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1217 0.1899 0.1899
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0563 0.0862 0.0855
Echinococcus granulosus survival motor neuron protein 1 0.0264 0.0388 0.0388
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0554 0.0849 0.0848
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0025 0.0009 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.013 0.0176 0.0176
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0025 0.0025
Plasmodium vivax hypothetical protein 0.042 0.0635 0.948
Toxoplasma gondii histone lysine methyltransferase SET1 0.0098 0.0126 0.0168
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0016 0.0015
Schistosoma mansoni cation-transporting atpase worm 0.0025 0.0009 0.0009
Plasmodium vivax hypothetical protein, conserved 0.042 0.0635 0.948
Trichomonas vaginalis PIKK family atypical protein kinase 0.5044 0.7963 0.7961
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.0117 0.0116
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2985 0.4701 0.4696
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.0173 0.0172
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0121 0.0162 0.9693
Trichomonas vaginalis cation-transporting ATPase, putative 0.0025 0.0009 0.0002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0034 0.0025 0.0024
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0121 0.0162 0.0161
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1217 0.1899 0.1899
Leishmania major phosphatidylinositol 4-kinase, putative 0.042 0.0635 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.3439 0.542 0.5417
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0441 0.067 0.0669
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0025 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.1217 0.1899 0.1893
Brugia malayi hypothetical protein 0.0062 0.0068 0.0068
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0441 0.067 0.067
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.042 0.0635 0.0852
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0486 0.074 0.074
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.042 0.0635 0.0627
Trichomonas vaginalis PIKK family atypical protein kinase 0.4107 0.6479 0.6477
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2153 0.3383 0.3377
Onchocerca volvulus 0.0029 0.0016 0.0234
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0162 0.0161
Brugia malayi beta-lactamase 0.0029 0.0016 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0016 0.0009
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6329 1 1
Entamoeba histolytica hypothetical protein 0.0062 0.0068 0.0059
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0025 0.0009 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0044 0.0638
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.006 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0016 0.0009
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2165 0.3402 0.3396
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0008 0.0007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0174 0.2628
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0121 0.0162 0.2413
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0025 0.0009 0.0008
Onchocerca volvulus 0.042 0.0635 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0012 0.0161
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2209 0.3472 0.3472
Entamoeba histolytica hypothetical protein 0.0062 0.0068 0.0059
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0025 0.0009 0.0002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.051 0.0778 0.077
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0025 0.0009 0.0008
Brugia malayi CXXC zinc finger family protein 0.0052 0.0053 0.0052
Echinococcus multilocularis lamin dm0 0.003 0.0018 0.0017
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0486 0.074 0.074
Leishmania major peptidylprolyl isomerase-like protein 0.0121 0.0162 0.0161
Brugia malayi hypothetical protein 0.0046 0.0044 0.0043
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0012 0.0157
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0441 0.067 0.0663
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0554 0.0849 0.0848
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2209 0.3472 0.3471
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0025 0.0009 0.0002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2209 0.3472 0.3471
Trichomonas vaginalis PIKK family atypical protein kinase 0.2153 0.3383 0.3378
Mycobacterium tuberculosis Probable lipase LipE 0.0029 0.0016 0.011
Echinococcus multilocularis phosphoserine phosphatase 0.0025 0.0009 0.0008
Brugia malayi beta-lactamase family protein 0.0029 0.0016 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.5044 0.7963 0.7961
Echinococcus multilocularis cation transporting atpase worm 0.0025 0.0009 0.0008
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0023 0.0008 0.0007
Echinococcus multilocularis fk506 binding protein 0.0121 0.0162 0.0161
Echinococcus multilocularis phosphoserine phosphatase 0.0025 0.0009 0.0008
Giardia lamblia Phosphatidylinositol 4-kinase 0.042 0.0635 0.0627
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0441 0.067 0.0663
Leishmania major mitochondrial DNA polymerase beta 0.0236 0.0344 0.0343
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1217 0.1899 0.1899
Echinococcus multilocularis serine protein kinase ATM 0.1217 0.1899 0.1899
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0441 0.067 0.067
Schistosoma mansoni tar DNA-binding protein 0.006 0.0065 0.0065
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0008 0.0007
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5049 0.7971 0.7969
Onchocerca volvulus 0.0029 0.0016 0.0234
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0162 0.0161
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0025 0.0009 0.0008
Onchocerca volvulus 0.042 0.0635 1

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 25 uM Concentrations of compound at which 50% Form I DNA was converted into Form II DNA of Phi X 174 ChEMBL. 15125931
IC50 (functional) = 5.6 uM Cytotoxicity of compound against HeLa S3 cells exposed to compound with 72 h photoirradiation ChEMBL. 15125931
IC50 (functional) = 5.6 uM Cytotoxicity of compound against HeLa S3 cells exposed to compound with 72 h photoirradiation ChEMBL. 15125931
IC50 (functional) > 100 uM Cytotoxicity of compound against HeLa S3 cells without photoirradiation ChEMBL. 15125931
IC50 (functional) > 100 uM Cytotoxicity of compound against HeLa S3 cells without photoirradiation ChEMBL. 15125931

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15125931

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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