Detailed information for compound 1570051

Basic information

Technical information
  • TDR Targets ID: 1570051
  • Name: ethyl N-[2-(ethoxycarbonylcarbamoyl)-3-[(3-me thoxyphenyl)amino]prop-2-enoyl]carbamate
  • MW: 379.365 | Formula: C17H21N3O7
  • H donors: 3 H acceptors: 4 LogP: 2.99 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)NC(=O)C(=CNc1cccc(c1)OC)C(=O)NC(=O)OCC
  • InChi: 1S/C17H21N3O7/c1-4-26-16(23)19-14(21)13(15(22)20-17(24)27-5-2)10-18-11-7-6-8-12(9-11)25-3/h6-10,18H,4-5H2,1-3H3,(H,19,21,23)(H,20,22,24)
  • InChiKey: DAJSRWWSSQQJAE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(ethoxycarbonylamino)-oxomethyl]-3-[(3-methoxyphenyl)amino]-1-oxoprop-2-enyl]carbamic acid ethyl ester
  • N-[2-(carbethoxycarbamoyl)-3-[(3-methoxyphenyl)amino]acryloyl]carbamic acid ethyl ester
  • ethyl 2-{[(ethoxycarbonyl)amino]carbonyl}-3-(3-methoxyanilino)acryloylcarbamate
  • AJ-030/14523465
  • ZINC04419730
  • MLS000702191
  • SMR000226751

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0468 0.1406
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0099 0.0269
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0593 0.1459
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0593 0.1459
Loa Loa (eye worm) hypothetical protein 0.0024 0.0217 0.0203
Echinococcus granulosus peregrin 0.0033 0.0369 0.1099
Echinococcus granulosus tyrosine protein kinase Src42A 0.0034 0.0386 0.1152
Schistosoma mansoni nuclear receptor 0.0019 0.0128 0.0393
Schistosoma mansoni hypothetical protein 0.0205 0.3254 1
Toxoplasma gondii ribonuclease HI protein 0.0023 0.02 0.2046
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0128 0.0114
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0593 0.1459
Onchocerca volvulus 0.0019 0.0128 0.0206
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0217 0.0666
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.0625 0.4306
Echinococcus multilocularis caspase 3 0.0076 0.1095 0.3341
Echinococcus granulosus tyrosine protein kinase HCK 0.0031 0.0339 0.1007
Brugia malayi PHD-finger family protein 0.0031 0.0327 0.0313
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0481 0.1478
Schistosoma mansoni hypothetical protein 0.0022 0.0176 0.0542
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0053 0.0702 0.4803
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1436 0.3578
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.021 0.0611
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0593 0.1459
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0049 0.0644 0.4439
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0152
Echinococcus granulosus tyrosine protein kinase Blk 0.0035 0.0404 0.1209
Echinococcus granulosus acetylcholinesterase 0.0142 0.2204 0.676
Brugia malayi Bromodomain containing protein 0.0079 0.1135 0.1123
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0593 0.1459
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0481 0.0467
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0481 0.0467
Entamoeba histolytica hypothetical protein 0.0038 0.0447 0.3054
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0066 0.0166
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0049 0.0644 0.4439
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0128 0.0393
Echinococcus multilocularis GPCR, family 2 0.0019 0.0133 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0481 0.0467
Echinococcus multilocularis zinc finger protein 0.0021 0.0158 0.0449
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0152
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0176 0.0162
Loa Loa (eye worm) hypothetical protein 0.0024 0.0217 0.0203
Leishmania major hypothetical protein, conserved 0.0016 0.0082 0.0413
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0481 0.1446
Loa Loa (eye worm) hypothetical protein 0.0024 0.0217 0.0203
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0447 0.1341
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Echinococcus granulosus jun protein 0.0088 0.1294 0.3953
Schistosoma mansoni caspase-7 (C14 family) 0.0123 0.1875 0.5763
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0128 0.0357
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0053 0.0702 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0481 0.0467
Brugia malayi hypothetical protein 0.0021 0.0166 0.0152
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0036 0.0411 0.5141
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0128 0.0393
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0066 0.0166
Brugia malayi hypothetical protein 0.0069 0.0976 0.0963
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0481 0.1478
Trypanosoma cruzi metacaspase, putative 0.0046 0.0593 0.4077
Schistosoma mansoni nicalin (M28 family) 0.0013 0.0024 0.0074
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0469 0.0455
Brugia malayi FXNA 0.0013 0.0024 0.001
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0128 0.0393
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0825 0.0812
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0481 0.0467
Brugia malayi hypothetical protein 0.0071 0.1008 0.0995
Plasmodium vivax metacaspase 1, putative 0.0046 0.0593 0.8173
Echinococcus granulosus Ankyrin 0.0015 0.0068 0.0173
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0133 0.0119
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0053 0.0702 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0481 0.0467
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0481 0.1446
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0884 0.0897
Entamoeba histolytica protein kinase, putative 0.0031 0.0339 0.2291
Loa Loa (eye worm) hypothetical protein 0.0046 0.0593 0.0579
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0128 0.0114
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0825 0.0812
Leishmania major metacaspase, putative 0.0046 0.0593 0.4028
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0049 0.0644 0.1588
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0306
Schistosoma mansoni troponin I 0.0109 0.1648 0.5064
Trypanosoma brucei ISWI complex protein 0.0016 0.0082 0.0491
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0128 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0593 0.1459
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0025 0.0233 0.1548
Trypanosoma cruzi glutaminyl cyclase, putative 0.0013 0.0024 0.0081
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0327 0.0313
Schistosoma mansoni phosphoglucomutase 0.0023 0.02 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0593 0.1459
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.1111 0.3391
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0469 0.144
Echinococcus granulosus ribonuclease H1 0.0023 0.02 0.0579
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.02 0.1317
Loa Loa (eye worm) hypothetical protein 0.0024 0.0217 0.0203
Brugia malayi RNase H family protein 0.0023 0.02 0.0186
Loa Loa (eye worm) hypothetical protein 0.0052 0.0694 0.0681
Loa Loa (eye worm) DR-78 0.0019 0.0128 0.0114
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0066 0.0166
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0128 0.0357
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1436 0.3578
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0039 0.0468 0.1406
Trichomonas vaginalis spcc417.12 protein, putative 0.0024 0.0217 0.0513
Onchocerca volvulus 0.0249 0.3993 0.7858
Schistosoma mansoni troponin I 0.0109 0.1648 0.5064
Schistosoma mansoni thyroid hormone receptor 0.004 0.0481 0.1478
Echinococcus granulosus oncosphere protein Tso22e 0.0135 0.2089 0.6407
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0481 0.0467
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0481 0.0905
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0539 0.1626
Brugia malayi Carboxylesterase family protein 0.0142 0.2204 0.2193
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0593 0.1459
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0582 0.9602 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0481 0.1446
Brugia malayi Peptidase family M28 containing protein 0.0013 0.0024 0.001
Giardia lamblia Kinase, PLK 0.0097 0.1436 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0128 0.0114
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.1111 0.3391
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0024 0.0217 0.063
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0128 0.0206
Brugia malayi RNase H family protein 0.0023 0.02 0.0186
Brugia malayi nuclear receptor RXR 0.0019 0.0128 0.0114
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0128 0.0357
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0166 0.0152
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0039 0.0468 0.1406
Mycobacterium ulcerans methionine aminopeptidase 0.0036 0.0411 0.0404
Loa Loa (eye worm) hypothetical protein 0.0045 0.0565 0.0551
Loa Loa (eye worm) hypothetical protein 0.0086 0.1253 0.1241
Brugia malayi Carboxylesterase family protein 0.0024 0.0217 0.0203
Schistosoma mansoni netrin receptor unc5 0.0015 0.0066 0.0203
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0825 0.0812
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0128 0.0393
Echinococcus multilocularis BC026374 protein (S09 family) 0.0024 0.0217 0.063
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1436 0.3578
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.064 0.1966
Schistosoma mansoni Smad4 0.0017 0.0099 0.0306
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0128 0.0114
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0066 0.0052
Loa Loa (eye worm) troponin 0.0065 0.0901 0.0888
Trypanosoma cruzi metacaspase, putative 0.0046 0.0593 0.4077
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1497 0.4579
Schistosoma mansoni troponin I 0.0109 0.1648 0.5064
Echinococcus multilocularis tyrosine protein kinase Srms 0.0035 0.0404 0.1209
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0053 0.0702 0.4845
Brugia malayi nicalin 0.0013 0.0024 0.001
Brugia malayi conserved hypotetical protein 0.0019 0.0128 0.0114
Echinococcus granulosus tyrosine protein kinase Src64B 0.0039 0.0468 0.1406
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0071 0.1008 0.307
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Schistosoma mansoni tyrosine kinase 0.0039 0.0468 0.1438
Brugia malayi hypothetical protein 0.0313 0.5075 0.5067
Treponema pallidum methionine aminopeptidase (map) 0.0036 0.0411 1
Loa Loa (eye worm) carboxylesterase 0.0024 0.0217 0.0203
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Schistosoma mansoni hypothetical protein 0.0086 0.1265 0.3888
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0539 0.1626
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0133 0.0119
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0128 0.0114
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0066 0.0203
Brugia malayi Protein kinase domain containing protein 0.0015 0.0071 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0481 0.1446
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0049 0.0644 0.7217
Onchocerca volvulus 0.004 0.0481 0.0905
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0128 0.0357
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.1436 1
Trypanosoma brucei metacaspase MCA3 0.0046 0.0593 0.4077
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0593 0.4077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0481 0.0467
Loa Loa (eye worm) leucyl aminopeptidase 0.0013 0.0024 0.001
Loa Loa (eye worm) hypothetical protein 0.004 0.0481 0.0467
Trypanosoma brucei metacaspase 0.0046 0.0593 0.4077
Loa Loa (eye worm) TK protein kinase 0.0035 0.0404 0.039
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1436 0.3578
Echinococcus multilocularis neuroligin 0.0024 0.0217 0.063
Schistosoma mansoni zinc finger protein 0.0016 0.0082 0.0253
Brugia malayi Methionine aminopeptidase protein type I 0.0053 0.0702 0.0689
Onchocerca volvulus Troponin I homolog 0.0109 0.1648 0.3215
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0049 0.0644 0.1228
Loa Loa (eye worm) hypothetical protein 0.004 0.0481 0.0467
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0053 0.0702 0.2128
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0128 0.0114
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.02 0.1317
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0468 0.1406
Loa Loa (eye worm) troponin I 0.0109 0.1648 0.1636
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0327 0.097
Schistosoma mansoni phosphoglucomutase 0.0023 0.02 0.0614
Echinococcus granulosus carboxylesterase 5A 0.0142 0.2204 0.676
Schistosoma mansoni coup transcription factor 0.004 0.0481 0.1478
Schistosoma mansoni nuclear hormone receptor 0.004 0.0481 0.1478
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0217 0.0666
Brugia malayi MH2 domain containing protein 0.0017 0.0099 0.0085
Loa Loa (eye worm) methionine aminopeptidase type I 0.0053 0.0702 0.0689
Echinococcus multilocularis ribonuclease H1 0.0023 0.02 0.0579
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1436 0.3578
Echinococcus multilocularis caspase 2 0.009 0.1319 0.4032
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0013 0.0024 0.0036
Entamoeba histolytica methionine aminopeptidase, putative 0.0049 0.0644 0.4439
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0481 0.1446
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0039 0.0468 0.1406
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0327 0.1004
Trypanosoma brucei glutaminyl cyclase, putative 0.0013 0.0024 0.0081
Brugia malayi nuclear receptor NHR-88 0.004 0.0481 0.0467
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0446 0.1339
Schistosoma mansoni kinase 0.0049 0.0638 0.1959
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0593 0.1459
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0066 0.0083
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0039 0.0468 0.1406
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0123 0.1875 0.5747
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0036 0.0411 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0099 0.0269
Echinococcus granulosus geminin 0.0205 0.3254 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0481 0.0467
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0053 0.0702 0.4845
Brugia malayi Uncoordinated protein 44 0.0015 0.0066 0.0052
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.0195 0.1281
Trypanosoma brucei metacaspase 5, putative 0.0046 0.0593 0.4077
Schistosoma mansoni bromodomain containing protein 0.0066 0.0929 0.2854
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0068 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0593 0.1459
Brugia malayi tailless protein 0.0019 0.0128 0.0114
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0306
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0113 0.0348
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0049 0.0644 0.1588
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0013 0.0024 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0481 0.1446
Leishmania major hypothetical protein, conserved 0.0023 0.0195 0.1209
Echinococcus granulosus death domain containing protein 0.0015 0.0066 0.0166
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.4024 0.4015
Schistosoma mansoni tsg101-related 0.0059 0.0808 0.2482
Entamoeba histolytica hypothetical protein 0.0038 0.0447 0.3054
Chlamydia trachomatis methionine aminopeptidase 0.0036 0.0411 0.5
Brugia malayi Carboxylesterase family protein 0.0024 0.0217 0.0203
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0233 0.1548
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0124 0.011
Schistosoma mansoni hypothetical protein 0.0019 0.0133 0.0408
Echinococcus granulosus BC026374 protein S09 family 0.0024 0.0217 0.063
Echinococcus multilocularis tyrosine protein kinase HCK 0.0031 0.0339 0.1007
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0036 0.0411 0.5141
Onchocerca volvulus 0.0043 0.0539 0.102
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0481 0.1478
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0099 0.0269
Brugia malayi hypothetical protein 0.0038 0.0447 0.0433
Brugia malayi Carboxylesterase family protein 0.0024 0.0217 0.0203
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0884 0.2688
Loa Loa (eye worm) hypothetical protein 0.0024 0.0217 0.0203
Trypanosoma cruzi metacaspase, putative 0.0046 0.0593 0.4077
Echinococcus granulosus caspase 3 0.0076 0.1095 0.3341
Echinococcus granulosus acetylcholinesterase 0.0142 0.2204 0.676
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0481 0.1446
Schistosoma mansoni gliotactin 0.0024 0.0217 0.0666
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.064 0.1966
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.064 0.1936
Schistosoma mansoni hypothetical protein 0.0016 0.0082 0.0253
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0054
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.001
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0036 0.0411 0.1264
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0339 0.1008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0468 0.1406
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0327 0.097
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0013 0.0024 0.0036
Loa Loa (eye worm) hypothetical protein 0.0031 0.0327 0.0313
Loa Loa (eye worm) hypothetical protein 0.0074 0.106 0.1047
Loa Loa (eye worm) carboxylesterase 0.0024 0.0217 0.0203
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0013 0.0024 0.0036
Loa Loa (eye worm) hypothetical protein 0.004 0.0481 0.0467
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0593 0.6617
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0024 0.0217 0.0201
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0468 0.1406
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.001
Loa Loa (eye worm) hypothetical protein 0.004 0.0489 0.0476
Brugia malayi Smad1 0.0017 0.0099 0.0085
Loa Loa (eye worm) hypothetical protein 0.0049 0.064 0.0626
Loa Loa (eye worm) initiation factor 2-associated protein 0.0049 0.0644 0.0631
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0166 0.0473
Echinococcus multilocularis carboxylesterase 5A 0.0142 0.2204 0.676
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0217 0.0666
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0884 0.2715
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0481 0.0467
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0233 0.1548
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0113 0.0312
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0616 0.1518
Entamoeba histolytica hypothetical protein 0.0038 0.0447 0.3054
Entamoeba histolytica hypothetical protein 0.0038 0.0447 0.3054
Echinococcus multilocularis Smad4 0.0017 0.0099 0.0269
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0099 0.0306
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0593 0.4077
Mycobacterium tuberculosis Carboxylesterase LipT 0.0024 0.0217 0.0201
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0481 0.0467
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0166 0.0152
Brugia malayi PHD-finger family protein 0.0026 0.0252 0.0238
Echinococcus granulosus neuroligin 0.0024 0.0217 0.063
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0435 0.1304
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0481 0.1446
Leishmania major hypothetical protein, conserved 0.0017 0.0103 0.0563
Onchocerca volvulus 0.0024 0.0217 0.0381
Echinococcus granulosus caspase 8 0.0046 0.0593 0.1791
Schistosoma mansoni phosphoglucomutase 0.0023 0.02 0.0614
Plasmodium falciparum metacaspase 1 0.0046 0.0593 0.8173
Schistosoma mansoni tyrosine kinase 0.0039 0.0468 0.1438
Brugia malayi Bromodomain containing protein 0.004 0.0488 0.0474
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0024 0.0217 0.0513
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0049 0.0644 0.4439
Brugia malayi hypothetical protein 0.0019 0.0128 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0481 0.0467
Brugia malayi MH1 domain containing protein 0.0017 0.0099 0.0085
Echinococcus multilocularis tyrosine protein kinase Blk 0.0035 0.0404 0.1209
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0481 0.1478
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0481 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0481 0.0467
Brugia malayi Cell death protein 3 precursor 0.009 0.1319 0.1307
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0481 0.0905
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0166 0.0473
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0233 0.1548
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0339 0.3665
Echinococcus granulosus troponin i 0.0109 0.1648 0.5045
Trichomonas vaginalis ribonuclease H1, putative 0.0023 0.02 0.0471
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0469 0.144
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0113 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0481 0.0467
Brugia malayi Troponin family protein 0.0109 0.1648 0.1636
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0135 0.2089 0.6407
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0884 0.0897
Plasmodium vivax SET domain protein, putative 0.0031 0.0339 0.3935
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0013 0.0024 0.0036
Schistosoma mansoni zinc finger protein 0.0021 0.0158 0.0485
Brugia malayi steroid hormone receptor 0.004 0.0481 0.0467
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.1436 0.2795
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0884 0.2715
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0528 0.1591
Schistosoma mansoni troponin t invertebrate 0.0135 0.2089 0.642
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0103 0.0639
Schistosoma mansoni jun-related protein 0.0072 0.1016 0.3123
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0874 0.0861
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0481 0.0467
Schistosoma mansoni nuclear receptor 0.0019 0.0128 0.0393
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0593 0.6617
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0481 0.1446
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0481 0.1478
Trypanosoma brucei Metacaspase-4 0.0046 0.0593 0.4077
Echinococcus granulosus caspase 0.0123 0.1875 0.5747
Brugia malayi MH1 domain containing protein 0.0017 0.0099 0.0085
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0884 0.0897
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0469 0.1408
Schistosoma mansoni tsg101-related 0.0059 0.0808 0.2482
Brugia malayi Pre-SET motif family protein 0.0031 0.0339 0.0325
Onchocerca volvulus 0.0069 0.0976 0.1884
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0123 0.1875 0.5747
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.4024 0.4015
Echinococcus multilocularis geminin 0.0205 0.3254 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0088 0.1294 0.3953
Schistosoma mansoni jumonji domain containing protein 0.008 0.1151 0.3536
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.001
Trypanosoma brucei ribonuclease H1 0.0023 0.02 0.1317
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0049 0.0644 0.4439
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0103 0.0639
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.1436 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.1436 0.1424
Schistosoma mansoni caspase-3 (C14 family) 0.0123 0.1875 0.5763
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0481 0.0467
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0593 0.6617
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1436 0.3578
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0481 0.0467
Plasmodium vivax methionine aminopeptidase 2, putative 0.0049 0.0644 0.9034
Onchocerca volvulus Ribonuclease H1 homolog 0.0023 0.02 0.0348
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0036 0.0411 0.1264
Schistosoma mansoni thyroid hormone receptor 0.004 0.0481 0.1478
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0049 0.0644 0.198
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0616 0.1518
Brugia malayi Troponin T 0.0065 0.0901 0.0888
Brugia malayi nuclear receptor NHR-67 0.0019 0.0128 0.0114
Echinococcus granulosus FTZ F1 alpha 0.004 0.0481 0.1446
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0593 0.1459
Brugia malayi MH2 domain containing protein 0.025 0.4024 0.4015
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0128 0.0357
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0468 0.1406
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0013 0.0024 0.0074
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.001
Echinococcus multilocularis acetylcholinesterase 0.0142 0.2204 0.676
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0099 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0593 0.1459
Loa Loa (eye worm) hypothetical protein 0.006 0.0825 0.0812
Brugia malayi RNase H family protein 0.0023 0.02 0.0186
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0046 0.0593 0.0579
Onchocerca volvulus 0.0019 0.0128 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0481 0.0467
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0481 0.1446
Brugia malayi nuclear receptor RXR 0.0021 0.0166 0.0152
Loa Loa (eye worm) carboxylesterase 0.0142 0.2204 0.2193
Echinococcus granulosus Smad4 0.0017 0.0099 0.0269
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0481 0.1478
Brugia malayi Troponin T 0.0065 0.0901 0.0888
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0481 0.0467
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0039 0.0468 0.1406
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0327 0.373
Brugia malayi hypothetical protein 0.0043 0.0539 0.0526
Loa Loa (eye worm) TK protein kinase 0.0031 0.0339 0.0325
Toxoplasma gondii methionine aminopeptidase 0.0053 0.0702 0.789
Echinococcus multilocularis caspase 8 0.0046 0.0593 0.1791
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0024 0.0217 0.0201
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0152
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.1436 0.4391
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0113 0.0348
Loa Loa (eye worm) hypothetical protein 0.0606 1 1
Schistosoma mansoni hypothetical protein 0.0031 0.0327 0.1004
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0029
Schistosoma mansoni hypothetical protein 0.0019 0.0133 0.0408
Loa Loa (eye worm) hypothetical protein 0.0109 0.1648 0.1636
Trichomonas vaginalis hypothetical protein 0.0035 0.0395 0.0961
Schistosoma mansoni Fxna peptidase (M28 family) 0.0013 0.0024 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0339 0.1042
Brugia malayi Bromodomain containing protein 0.0033 0.0369 0.0355
Trypanosoma cruzi ISWI complex protein 0.0016 0.0082 0.0491
Schistosoma mansoni hypothetical protein 0.0019 0.0133 0.0408
Trypanosoma cruzi ISWI complex protein 0.0016 0.0082 0.0491
Giardia lamblia PHD finger protein 15 0.0031 0.0327 0.1026
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.1436 1
Loa Loa (eye worm) troponin T 0.0065 0.0901 0.0888
Trypanosoma brucei RNA helicase, putative 0.0086 0.1265 0.88
Brugia malayi bZIP transcription factor family protein 0.0088 0.1294 0.1281
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0884 0.6088
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0166 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0029
Trypanosoma brucei metacaspase MCA2 0.0046 0.0593 0.4077
Echinococcus granulosus GPCR family 2 0.0019 0.0133 0.0372
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0468 0.1406
Loa Loa (eye worm) hypothetical protein 0.0109 0.1648 0.1636
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0128 0.0357
Brugia malayi Carboxylesterase family protein 0.0142 0.2204 0.2193
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.021 0.0646
Plasmodium falciparum phd finger protein, putative 0.0031 0.0327 0.373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0339 0.1042
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0099 0.0269
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0447 0.1341
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0036 0.0411 0.0404
Onchocerca volvulus Alhambra homolog 0.0031 0.0327 0.0599
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0481 0.1478
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0481 0.1446
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0128 0.0357
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0128 0.0357
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0133 0.0372
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0128 0.0114
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0593 0.1459
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0103 0.0639
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0481 0.1446
Brugia malayi hypothetical protein 0.0019 0.0128 0.0114
Schistosoma mansoni hypothetical protein 0.0043 0.0539 0.1657
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0884 0.0897
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0071 0.1008 0.307
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0128 0.0393
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0468 0.1406
Echinococcus multilocularis Ankyrin 0.0015 0.0068 0.0173
Loa Loa (eye worm) hypothetical protein 0.004 0.0481 0.0467
Brugia malayi protein-tyrosine kinase 0.0035 0.0404 0.039
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0447 0.1374
Loa Loa (eye worm) hypothetical protein 0.0065 0.0901 0.0888
Schistosoma mansoni hypothetical protein 0.0205 0.3254 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0152
Loa Loa (eye worm) hypothetical protein 0.004 0.0481 0.0467
Brugia malayi Pre-SET motif family protein 0.0218 0.3483 0.3474
Leishmania major ribonuclease H1, putative 0.0023 0.02 0.1246
Brugia malayi ecdysone receptor 0.0019 0.0128 0.0114
Brugia malayi Troponin I 0.0109 0.1648 0.1636
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0481 0.1446
Echinococcus multilocularis para nitrobenzyl esterase 0.0024 0.0217 0.063
Schistosoma mansoni zinc finger protein 0.0019 0.0128 0.0393
Loa Loa (eye worm) hypothetical protein 0.004 0.0481 0.0467
Schistosoma mansoni neuroligin 3 (S09 family) 0.0024 0.0217 0.0666
Brugia malayi follicle stimulating hormone receptor 0.0243 0.3898 0.3889
Schistosoma mansoni hypothetical protein 0.0041 0.0505 0.1551
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0528 0.1591
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0036 0.0411 0.0404
Schistosoma mansoni tsg101-related 0.0048 0.0625 0.1922
Brugia malayi nuclear hormone receptor 0.004 0.0481 0.0467
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0481 0.1446
Loa Loa (eye worm) hypothetical protein 0.0024 0.0217 0.0203
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0166 0.0152
Trypanosoma cruzi glutaminyl cyclase, putative 0.0013 0.0024 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.1436 0.4413
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0582 0.9602 1
Echinococcus multilocularis troponin i 0.0109 0.1648 0.5045
Echinococcus granulosus tyrosine kinase 0.0035 0.0404 0.1209
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0013 0.0024 0.0036
Brugia malayi Death domain containing protein 0.0015 0.0066 0.0052
Loa Loa (eye worm) hypothetical protein 0.0043 0.0531 0.0517
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0053 0.0702 0.4845
Loa Loa (eye worm) hypothetical protein 0.0021 0.0166 0.0152
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0046 0.0593 0.1822
Loa Loa (eye worm) SRC-1 0.0039 0.0468 0.0454
Plasmodium falciparum metacaspase-like protein 0.0046 0.0593 0.8173
Echinococcus granulosus methionyl aminopeptidase 2 0.0049 0.0644 0.195
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0327 0.3522
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0088 0.1294 0.3953
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.0195 0.1281
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0024 0.0217 0.063
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0034 0.0386 0.1152
Schistosoma mansoni hypothetical protein 0.0109 0.1648 0.5064
Brugia malayi MH2 domain containing protein 0.0017 0.0099 0.0085
Loa Loa (eye worm) acetylcholinesterase 1 0.0142 0.2204 0.2193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0481 0.0467
Schistosoma mansoni smad 0.0017 0.0099 0.0306
Brugia malayi Carboxylesterase family protein 0.0024 0.0217 0.0203
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0166 0.0509
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0034 0.0019
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0481 0.1478
Brugia malayi leucyl aminopeptidase 0.0013 0.0024 0.001
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0481 0.1446
Loa Loa (eye worm) hypothetical protein 0.0142 0.2204 0.2193
Trypanosoma brucei polo-like protein kinase 0.0097 0.1436 1
Trypanosoma brucei unspecified product 0.0025 0.0233 0.1548
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0128 0.0357
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0013 0.0024 0.0029
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0066 0.0166
Echinococcus multilocularis methionyl aminopeptidase 2 0.0049 0.0644 0.195
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0128 0.0206
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.3483 0.3474
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0128 0.0114
Schistosoma mansoni hypothetical protein 0.0019 0.0133 0.0408
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0128 0.0357
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0593 0.8173
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0446 0.1339
Schistosoma mansoni hypothetical protein 0.0015 0.0066 0.0203
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0036 0.0411 0.1231
Loa Loa (eye worm) Smad1 0.0017 0.0099 0.0085
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0039 0.0468 0.1406
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Brugia malayi hypothetical protein 0.0024 0.0217 0.0203
Schistosoma mansoni hypothetical protein 0.0072 0.1016 0.3123
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0481 0.0905
Toxoplasma gondii methionine aminopeptidase 0.0036 0.0411 0.4505
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0128 0.0357
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1497 0.4579
Onchocerca volvulus 0.0031 0.0339 0.0624
Plasmodium falciparum methionine aminopeptidase 2 0.0049 0.0644 0.9034
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0142 0.2204 0.6772
Schistosoma mansoni smad1 5 8 and 0.0017 0.0099 0.0306
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0481 0.1478
Brugia malayi hypothetical protein 0.0065 0.0901 0.0888
Echinococcus multilocularis acetylcholinesterase 0.0142 0.2204 0.676
Mycobacterium ulcerans carboxylesterase, LipT 0.0024 0.0217 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1436 0.3578
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.021 0.0611
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0119
Onchocerca volvulus 0.0024 0.0217 0.0381
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0135 0.2089 0.4089
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0013 0.0024 0.0036
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0066 0.0052
Onchocerca volvulus 0.0024 0.0217 0.0381
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0065 0.0901 0.1737
Brugia malayi SRC-1 0.0039 0.0468 0.0454
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0036 0.0411 0.4505
Brugia malayi jmjC domain containing protein 0.01 0.1497 0.1484
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0866 0.2632
Echinococcus granulosus zinc finger protein 0.0021 0.0158 0.0449
Loa Loa (eye worm) hypothetical protein 0.0043 0.0539 0.0526
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0582 0.9602 1
Onchocerca volvulus 0.0024 0.0217 0.0381
Toxoplasma gondii hypothetical protein 0.0017 0.0103 0.0924
Onchocerca volvulus 0.0313 0.5075 1
Giardia lamblia Methionine aminopeptidase 0.0049 0.0644 0.3596
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0133 0.0372
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0468 0.1406
Loa Loa (eye worm) hypothetical protein 0.0024 0.0217 0.0203
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0035 0.0404 0.1209
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0133 0.0372
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0327 0.3522
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.064 0.1936
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0128 0.0114
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0099 0.0085
Onchocerca volvulus 0.0024 0.0217 0.0381
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0049 0.0644 0.1588
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.1436 0.4391
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0053 0.0702 0.4845
Schistosoma mansoni troponin I 0.0109 0.1648 0.5064
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0133 0.0119
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0128 0.0114
Brugia malayi nuclear hormone receptor 0.0019 0.0128 0.0114
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.3898 0.3889
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.001
Trypanosoma brucei methionine aminopeptidase, putative 0.0053 0.0702 0.4845
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0505 0.0491
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.032 0.0948
Schistosoma mansoni acetylcholinesterase 0.0024 0.0217 0.0666
Echinococcus multilocularis peregrin 0.0033 0.0369 0.1099
Echinococcus granulosus smad 0.0017 0.0099 0.0269
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0481 0.1446
Echinococcus granulosus para nitrobenzyl esterase 0.0024 0.0217 0.063
Echinococcus granulosus caspase 2 0.009 0.1319 0.4032
Loa Loa (eye worm) hypothetical protein 0.0313 0.5075 0.5067
Brugia malayi hypothetical protein 0.0021 0.0166 0.0152
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0133 0.0372
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0866 0.2632
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0024 0.0029
Echinococcus granulosus tyrosine protein kinase Lyn 0.0039 0.0473 0.1422
Brugia malayi Troponin T 0.0065 0.0901 0.0888
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0039 0.0468 0.1406
Loa Loa (eye worm) hypothetical protein 0.009 0.1319 0.1307
Brugia malayi initiation factor 2-associated protein. 0.0049 0.0644 0.0631
Loa Loa (eye worm) hypothetical protein 0.0071 0.1008 0.0995
Echinococcus multilocularis smad 0.0017 0.0099 0.0269
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0013 0.0024 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0481 0.0467
Brugia malayi ecdysteroid receptor 0.004 0.0481 0.0467
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0593 0.1459
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0593 0.1459
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0114
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0049 0.0644 0.1588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0481 0.0467
Loa Loa (eye worm) hypothetical protein 0.0041 0.0505 0.0491
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0013 0.0024 0.0074
Schistosoma mansoni caspase-7 (C14 family) 0.009 0.1319 0.4055
Echinococcus multilocularis caspase 0.0123 0.1875 0.5747
Trypanosoma cruzi metacaspase, putative 0.0046 0.0593 0.4077
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.0404 0.1209
Brugia malayi jmjC domain containing protein 0.0039 0.0469 0.0455
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0884 0.2688
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0481 0.0467
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0884 1
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0481 0.0467
Leishmania major methionine aminopeptidase 2, putative 0.0049 0.0644 0.4393
Schistosoma mansoni BC026374 protein (S09 family) 0.0024 0.0217 0.0666
Echinococcus multilocularis jun protein 0.0088 0.1294 0.3953
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0053 0.0702 0.2128
Schistosoma mansoni hypothetical protein 0.0038 0.0447 0.1374
Trichomonas vaginalis set domain proteins, putative 0.0248 0.399 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0481 0.1446
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.1436 1
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0036 0.0411 0.0404
Loa Loa (eye worm) hypothetical protein 0.004 0.0481 0.0467
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.1436 0.1424
Onchocerca volvulus Cell death protein 3 homolog 0.009 0.1319 0.2565
Loa Loa (eye worm) hypothetical protein 0.0142 0.2204 0.2193

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0731 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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