Detailed information for compound 157045

Basic information

Technical information
  • TDR Targets ID: 157045
  • Name: N-[(2S)-1-oxo-1-(3-oxopyrrolidin-1-yl)-3-phen ylpropan-2-yl]pyridine-3-carboxamide
  • MW: 337.372 | Formula: C19H19N3O3
  • H donors: 1 H acceptors: 4 LogP: 1.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCN(C1)C(=O)[C@@H](NC(=O)c1cccnc1)Cc1ccccc1
  • InChi: 1S/C19H19N3O3/c23-16-8-10-22(13-16)19(25)17(11-14-5-2-1-3-6-14)21-18(24)15-7-4-9-20-12-15/h1-7,9,12,17H,8,10-11,13H2,(H,21,24)/t17-/m0/s1
  • InChiKey: MVCHKYHIVVDCAX-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1S)-1-benzyl-2-oxo-2-(3-oxopyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
  • N-[(1S)-1-benzyl-2-oxo-2-(3-oxo-1-pyrrolidinyl)ethyl]-3-pyridinecarboxamide
  • N-[(2S)-1-oxo-1-(3-oxopyrrolidin-1-yl)-3-phenyl-propan-2-yl]pyridine-3-carboxamide
  • N-[(1S)-1-benzyl-2-keto-2-(3-ketopyrrolidino)ethyl]nicotinamide
  • N-[(1S)-2-oxo-2-(3-oxopyrrolidin-1-yl)-1-(phenylmethyl)ethyl]pyridine-3-carboxamide
  • N-[(1S)-2-oxo-2-(3-oxo-1-pyrrolidinyl)-1-(phenylmethyl)ethyl]-3-pyridinecarboxamide
  • N-[(1S)-1-(benzyl)-2-keto-2-(3-ketopyrrolidin-1-yl)ethyl]nicotinamide
  • 1-[N-(Nicotinyl-3-carboxamide)-L-phenylalanyl]-3-pyrrolidinone
  • AIDS-058377
  • AIDS058377

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0054 0.0054
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.009 0.0158
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.002 0.0064
Schistosoma mansoni hypothetical protein 0.0255 0.0935 0.2159
Onchocerca volvulus Putative nachr subunit 0.002 0.002 0.0056
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0012 0.0012
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0023 0.0032 0.0102
Loa Loa (eye worm) RecQ helicase 0.004 0.0101 0.032
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0012 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) norepinephrine transporter 0.0016 0.0007 0.0022
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0829 0.3162 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0141 0.3525
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0059 0.2286
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Brugia malayi Sulfatase family protein 0.0017 0.0011 0.0034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0296
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0048 0.0131 0.0334
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Chlamydia trachomatis endonuclease IV 0.0075 0.0234 1
Schistosoma mansoni nAChR subunit 0.002 0.002 0.0046
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0089 0.2021
Toxoplasma gondii subtilisin SUB12 0.0015 0.0004 0.0041
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0007 0.0016
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0093 0.0214
Echinococcus granulosus serotonin transporter 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0017 0.0011 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0087 0.0275
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0216 0.0682
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0089 0.0089
Schistosoma mansoni thyroid hormone receptor 0.0292 0.1078 0.249
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0059 0.1295
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.002 0.0064
Onchocerca volvulus 0.0048 0.0131 0.0363
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0007 0.0016
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.009 0.2441
Echinococcus granulosus lamin 0.0083 0.0266 0.0266
Schistosoma mansoni loxhd1 0.002 0.002 0.0046
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0093 0.0093
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0231 0.084 0.194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0087 0.0275
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Brugia malayi hypothetical protein 0.0051 0.0141 0.0447
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0064 0.0513
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0369 0.0996
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0022
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2589 1 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.002 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0087 0.0087
Brugia malayi tailless protein 0.0017 0.0012 0.0037
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0093 0.0228
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0275
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0234 0.5664
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.025 0.0914 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0089 0.0289 0.0913
Toxoplasma gondii hypothetical protein 0.0016 0.0007 0.0076
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0093 0.0214
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0141 0.3356
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Brugia malayi hypothetical protein 0.0243 0.0889 0.2811
Treponema pallidum hypothetical protein 0.0048 0.0131 0.0235
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0131 0.0414
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.009 0.0879
Brugia malayi nuclear receptor RXR 0.0019 0.002 0.0062
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.002 0.0064
Echinococcus multilocularis lamin 0.0083 0.0266 0.0266
Schistosoma mansoni laminin gamma-3 chain 0.0054 0.0154 0.0355
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Brugia malayi phosphofructokinase 0.0109 0.0369 0.1167
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0369 0.0852
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Brugia malayi Cache domain containing protein 0.0521 0.1969 0.6225
Brugia malayi Pre-SET motif family protein 0.0829 0.3162 1
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0369 1
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0012
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0048 0.0131 0.0302
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0018 0.0077
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0016 0.0007 0.0007
Onchocerca volvulus 0.0048 0.0131 0.0363
Brugia malayi nuclear receptor RXR 0.0017 0.0012 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0408 0.0942
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0194 0.5252
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0093 0.0093
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0369 0.1167
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0076
Brugia malayi hypothetical protein 0.0238 0.0868 0.2746
Schistosoma mansoni cell polarity protein 0.0054 0.0154 0.0355
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.015
Brugia malayi intermediate filament protein 0.0083 0.0266 0.0842
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0073 0.023
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.009 0.2073
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0048 0.0131 0.5456
Onchocerca volvulus 0.0015 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0054 0.0154 0.0486
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0012 0.0012
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.002 0.002
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0093 0.0093
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0093 0.0214
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0087 0.0087
Toxoplasma gondii exonuclease III APE 0.0038 0.009 0.0986
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0266 0.0842
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0107 0.0359 0.0359
Toxoplasma gondii microneme protein MIC17B 0.0015 0.0004 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0012 0.0037
Brugia malayi hypothetical protein 0.0017 0.0012 0.0037
Schistosoma mansoni hypothetical protein 0.0608 0.2306 0.5325
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0087 0.0275
Loa Loa (eye worm) hypothetical protein 0.0028 0.0054 0.017
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) hypothetical protein 0.0238 0.0868 0.2746
Loa Loa (eye worm) hypothetical protein 0.0521 0.1969 0.6225
Schistosoma mansoni intermediate filament proteins 0.0083 0.0266 0.0615
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0022
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0064 0.1307
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0093 0.0093
Onchocerca volvulus 0.0024 0.0036 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0087 0.0275
Onchocerca volvulus 0.0048 0.0131 0.0363
Schistosoma mansoni serine-rich repeat protein 0.0608 0.2306 0.5325
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0054 0.0154 0.0355
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Brugia malayi hypothetical protein 0.0038 0.0093 0.0294
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0012 0.0027
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0007 0.0016
Schistosoma mansoni nAChR subunit 0.002 0.002 0.0046
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.002 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0087 0.0275
Schistosoma mansoni coup transcription factor 0.0037 0.0087 0.0201
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0064 0.1723
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0369 0.0369
Brugia malayi Cation transporter family protein 0.002 0.002 0.0064
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1371 0.5269 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0231 0.084 0.084
Schistosoma mansoni nAChR subunit 0.002 0.002 0.0046
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0087 0.0087
Plasmodium falciparum thrombospondin-related anonymous protein 0.0048 0.0131 0.5456
Entamoeba histolytica hypothetical protein 0.0038 0.0093 0.2517
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0007 0.0007
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0054 0.017
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.002 0.0064
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.002 0.0064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0275
Brugia malayi Pre-SET motif family protein 0.0119 0.0408 0.1289
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0089 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0087 0.0275
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0018 0.0077
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0059 0.0644
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.002 0.0046
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0048 0.0131 0.309
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.0868 0.2744
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.002 0.002
Brugia malayi PXA domain containing protein 0.0038 0.0093 0.0294
Brugia malayi nuclear receptor NHR-88 0.0037 0.0087 0.0275
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.025 0.0914 0.0914
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0369 0.392
Echinococcus granulosus lamin dm0 0.0083 0.0266 0.0266
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0007 0.0007
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0369 0.0688
Loa Loa (eye worm) hypothetical protein 0.0081 0.026 0.0823
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.002 0.002
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.009 0.0879
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.002 0.0045
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0087 0.0275
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0093 0.0093
Brugia malayi PXA domain containing protein 0.0038 0.0093 0.0294
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0087 0.0087
Loa Loa (eye worm) serotonin transporter b 0.0016 0.0007 0.0022
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0087 0.0087
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.002 0.002
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.002 0.0064
Toxoplasma gondii microneme protein MIC2 0.0048 0.0131 0.1432
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0093 0.0093
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0016 0.0005 0.0011
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Onchocerca volvulus 0.0028 0.0055 0.0152
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0036 0.0115
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.002 0.0064
Onchocerca volvulus 0.0017 0.0012 0.0032
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0054 0.0588
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0012 0.0012
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0032 0.0102
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.002 0.0046
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.002 0.002
Brugia malayi Kringle domain containing protein 0.0024 0.0036 0.0115
Loa Loa (eye worm) DR-78 0.0017 0.0012 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0012
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0093 0.0214
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0089 0.0205
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0054 0.0054
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.009 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Echinococcus multilocularis thyroid hormone receptor alpha 0.0292 0.1078 0.1078
Loa Loa (eye worm) abnormal epIthelia family member 0.0054 0.0154 0.0486
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.002 0.002
Echinococcus multilocularis RUN 0.002 0.002 0.002
Echinococcus granulosus tumor protein p63 0.035 0.1303 0.1302
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0093 0.0093
Echinococcus granulosus intermediate filament protein 0.0083 0.0266 0.0266
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0119 0.0408 0.0408
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0089 0.2021
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.009 0.5
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0359 0.083
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0059 0.0099
Loa Loa (eye worm) hypothetical protein 0.0119 0.0408 0.1289
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0087 0.0275
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.002 0.0046
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0089 0.028
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.002 0.002
Schistosoma mansoni nuclear receptor 0.0017 0.0012 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Onchocerca volvulus 0.0083 0.0266 0.0738
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.0093 0.0294
Plasmodium vivax SET domain protein, putative 0.0119 0.0408 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0087 0.0275
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.002 0.002
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0012
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0059 0.607
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0012 0.0012
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.025 0.0914 1
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0087 0.0201
Onchocerca volvulus 0.002 0.002 0.0056
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0064 0.1307
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0087 0.0087
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1178 0.4518 0.4518
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.002 0.0064
Onchocerca volvulus 0.0943 0.3607 1
Mycobacterium ulcerans endonuclease IV 0.0075 0.0234 0.2473
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0018 0.0018
Schistosoma mansoni lipoxygenase 0.0055 0.0157 0.0362
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0089 0.982
Treponema pallidum 76K protein 0.0048 0.0131 0.0235
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0369 0.3967
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0087 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0087 0.0275
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0016 0.0007 0.0022
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Brugia malayi Cytochrome P450 family protein 0.007 0.0216 0.0682
Echinococcus granulosus glycine receptor subunit beta 0.002 0.002 0.002
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Echinococcus granulosus dna polymerase eta 0.0019 0.0018 0.0018
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0093 0.0294
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0059 0.0134
Onchocerca volvulus 0.0049 0.0133 0.0368
Brugia malayi steroid hormone receptor 0.0037 0.0087 0.0275
Schistosoma mansoni nAChR subunit 0.002 0.002 0.0046
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.007 0.1483
Giardia lamblia DINP protein human, muc B family 0.0019 0.0018 0.0873
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Loa Loa (eye worm) doublecortin family protein 0.002 0.002 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0087 0.0087
Brugia malayi nuclear hormone receptor 0.0017 0.0012 0.0037
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0012 0.0037
Brugia malayi Fli-1 protein 0.0216 0.0782 0.2472
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0914 1
Echinococcus multilocularis nAChR subunit 0.002 0.002 0.002
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0048 0.0131 0.0414
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0059 0.2286
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0275
Toxoplasma gondii hypothetical protein 0.0015 0.0004 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0036 0.0532
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.002 0.002
Brugia malayi hypothetical protein 0.002 0.002 0.0063
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0194 0.0194
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.0093 0.0294
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0093 0.0093
Onchocerca volvulus 0.002 0.002 0.0056
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0255 0.0935 0.0935
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.002 0.0045
Toxoplasma gondii microneme protein MIC4 0.0015 0.0004 0.0041
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0369 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0569 0.2156 0.4977
Schistosoma mansoni DNA polymerase eta 0.0019 0.0018 0.0041
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.0036 0.0732
Plasmodium vivax thrombospondin-related anonymous protein 0.0048 0.0131 0.309
Schistosoma mansoni DNA helicase recq5 0.0028 0.0054 0.0124
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0059 0.2286
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0022
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0012 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0012 0.0012
Brugia malayi hypothetical protein 0.0017 0.0012 0.0037
Echinococcus multilocularis pikachurin 0.0054 0.0154 0.0154
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0109 0.0368 0.0368
Brugia malayi metabotropic glutamate receptor type 2 0.0043 0.0112 0.0354
Echinococcus granulosus glycine receptor subunit beta 0.002 0.002 0.002
Brugia malayi hypothetical protein 0.0106 0.0356 0.1126
Schistosoma mansoni hypothetical protein 0.002 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0036 0.0115
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Echinococcus granulosus dna polymerase kappa 0.0019 0.0018 0.0018
Loa Loa (eye worm) LGC-31 protein 0.002 0.002 0.0064
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0234 0.074
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0056
Loa Loa (eye worm) hypothetical protein 0.0083 0.0266 0.0842
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0093 0.0214
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0131 0.0414
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0141 0.5925
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.009 0.2061
Loa Loa (eye worm) hypothetical protein 0.0061 0.018 0.0569
Onchocerca volvulus 0.0051 0.0143 0.0396
Schistosoma mansoni zinc finger protein 0.0017 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.009 0.0808
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0048 0.0131 0.0414
Onchocerca volvulus 0.0083 0.0266 0.0738
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0087 0.0201
Schistosoma mansoni slit 0.0054 0.0154 0.0355
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0194 0.5014
Loa Loa (eye worm) hypothetical protein 0.0109 0.0368 0.1165
Plasmodium falciparum LCCL domain-containing protein 0.002 0.002 0.0576
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Brugia malayi 6-phosphofructokinase 0.0109 0.0369 0.1167
Brugia malayi follicle stimulating hormone receptor 0.0238 0.0868 0.2744
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0012 0.0012
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.009 0.0285
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0133 0.0419
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0087 0.0242
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0266 0.0842
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0093 0.0093
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0369 0.1167
Echinococcus multilocularis tumor protein p63 0.035 0.1303 0.1302
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0369 0.3967
Toxoplasma gondii microneme protein MIC17C 0.0015 0.0004 0.0041
Echinococcus multilocularis bloom syndrome protein 0.004 0.0101 0.0101
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0093 0.0294
Echinococcus granulosus expressed protein 0.0746 0.2841 0.2841
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0369 0.1167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Onchocerca volvulus 0.0015 0.0004 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0275
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0007 0.0007
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0087 0.0242
Loa Loa (eye worm) hypothetical protein 0.0054 0.0154 0.0486
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0054 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0087 0.0275
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0038 0.0764
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0194 0.0613
Onchocerca volvulus 0.0015 0.0004 0.001
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0054 0.5426
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0093 0.0093
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0119 0.0408 0.4463
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.022 0.022
Echinococcus granulosus geminin 0.0168 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.002 0.002
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0036 0.0036
Echinococcus granulosus pikachurin 0.0054 0.0154 0.0154
Brugia malayi ecdysteroid receptor 0.0037 0.0087 0.0275
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0076
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0634 0.2406 0.7609
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.022 0.0696
Onchocerca volvulus 0.002 0.002 0.0056
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0054 0.0588
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0034
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0018 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0012 0.0012
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0033 0.0033
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Onchocerca volvulus 0.0048 0.0131 0.0363
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1129 0.4331 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0087 0.0201
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0369 0.0996
Brugia malayi hypothetical protein 0.0019 0.002 0.0062
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0055 0.0173
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0073 0.023
Onchocerca volvulus 0.0015 0.0004 0.001
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.002 0.0064
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0087 0.0087
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0012 0.0012
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0089 0.0205
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.002 0.002
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0089 0.0089
Echinococcus granulosus cpg binding protein 0.003 0.0061 0.0061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.009 0.2061
Echinococcus granulosus metabotropic glutamate receptor 2 0.0074 0.0233 0.0233
Echinococcus granulosus bloom syndrome protein 0.004 0.0101 0.0101
Onchocerca volvulus 0.0015 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0087 0.0275
Brugia malayi 6-phosphofructokinase 0.0109 0.0369 0.1167
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.0036 0.1293
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.002 0.002
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0093 0.0294
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0012 0.0012
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0007 0.0007
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0868 0.0868
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.009 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0101 0.0336 0.0776
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.0004 0.0041
Schistosoma mansoni sodium-dependent amino acid transporter 0.0016 0.0007 0.0016
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Schistosoma mansoni survival motor neuron protein 0.0049 0.0133 0.0306
Onchocerca volvulus 0.002 0.002 0.0056
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Schistosoma mansoni cpg binding protein 0.003 0.0061 0.0141
Schistosoma mansoni DNA helicase recq1 0.0028 0.0054 0.0124
Schistosoma mansoni nAChR subunit 0.002 0.002 0.0046
Entamoeba histolytica elongation factor-2 kinase, putative 0.0048 0.0131 0.3547
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.002 0.0064
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0012 0.0032
Onchocerca volvulus 0.002 0.002 0.0056
Schistosoma mansoni metabotropic glutamate receptor 0.0074 0.0233 0.0537
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0234 0.2473
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0117 0.0369
Schistosoma mansoni cpg binding protein 0.0028 0.0055 0.0126
Loa Loa (eye worm) hypothetical protein 0.0107 0.0359 0.1136
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0012 0.0027
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.002 0.0046
Schistosoma mansoni rab6-interacting 0.002 0.002 0.0046
Echinococcus granulosus collagen alpha 1VII chain 0.0048 0.0131 0.0131
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0089 0.0217
Onchocerca volvulus 0.002 0.002 0.0056
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0075 0.0234 0.074
Leishmania major hypothetical protein, conserved 0.0024 0.0036 0.0209
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0141 0.5925
Echinococcus multilocularis lamin dm0 0.0083 0.0266 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0089 0.0217
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0171 0.1868
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0231 0.084 0.2657
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0087 0.0201
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0089 0.0089
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0087 0.0242
Brugia malayi hypothetical protein 0.0016 0.0007 0.0022
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0089 0.0792
Echinococcus granulosus dnaJ subfamily B 0.0406 0.152 0.152
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0093 0.0294
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.002 0.0064
Schistosoma mansoni lipoxygenase 0.002 0.002 0.0046
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0141 0.1548
Leishmania major hypothetical protein, conserved 0.0051 0.0141 0.1382
Echinococcus granulosus nAChR subunit 0.002 0.002 0.002
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0089 0.0089
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0018 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0275
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.002 0.002
Brugia malayi conserved hypotetical protein 0.0017 0.0012 0.0037
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0022
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0033 0.0033
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0359 0.083
Brugia malayi laminin-like protein K08C7.3 precursor 0.0054 0.0154 0.0486
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0087 0.0275
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0059 0.1596
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0131 0.309
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0089 0.0205
Loa Loa (eye worm) hypothetical protein 0.0051 0.0143 0.0452
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0087 0.0087
Echinococcus multilocularis slit 2 protein 0.0054 0.0154 0.0154
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.007 0.1891
Toxoplasma gondii hypothetical protein 0.0016 0.0007 0.0076
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.152 0.152
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0012 0.0027
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0369 0.0369
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0048 0.0131 0.309
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.002 0.0064
Onchocerca volvulus 0.0048 0.0131 0.0363
Brugia malayi hypothetical protein 0.0048 0.0131 0.0414
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.002 0.0107
Loa Loa (eye worm) CUTiclin family member 0.0048 0.0131 0.0414
Brugia malayi Ets-domain containing protein 0.0071 0.022 0.0696
Schistosoma mansoni rotamase 0.0033 0.0073 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0119 0.0408 0.0942
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0173
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0059 0.1295
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.007 0.1483
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Entamoeba histolytica hypothetical protein 0.0037 0.0089 0.2405
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.002 0.0107
Schistosoma mansoni nuclear receptor 0.0017 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Brugia malayi nuclear receptor NHR-67 0.0017 0.0012 0.0037
Echinococcus multilocularis neurogenic locus notch protein 0.0054 0.0154 0.0154
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0022
Schistosoma mansoni hypothetical protein 0.0023 0.0033 0.0075
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0054 0.017
Loa Loa (eye worm) solute carrier family 6 member 4 0.0016 0.0007 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.0119 0.0408 0.0408
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.002 0.0062
Loa Loa (eye worm) hypothetical protein 0.0054 0.0154 0.0486
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0059 0.0644
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0062
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0018 0.0077
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0018 0.0019
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0234 0.6129
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0045 0.0104
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0087 0.0201
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.002 0.002
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0074 0.0233 0.0233
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0093 0.0294
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0007 0.0016
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0012
Schistosoma mansoni cpg binding protein 0.003 0.0061 0.0141
Brugia malayi hypothetical protein 0.0017 0.0011 0.0034
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0107 0.0359 0.0359
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Schistosoma mansoni lamin 0.0083 0.0266 0.0615
Schistosoma mansoni hypothetical protein 0.0168 0.0597 0.1378
Echinococcus multilocularis dna polymerase eta 0.0019 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0168 0.0597 0.1378
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0141 0.3525
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0012 0.0037
Onchocerca volvulus 0.0037 0.0087 0.0242
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0035 0.0388
Brugia malayi Cation transporter family protein 0.002 0.002 0.0064
Brugia malayi hypothetical protein 0.002 0.002 0.0063
Brugia malayi hypothetical protein 0.0019 0.002 0.0062
Brugia malayi laminin alpha chain 0.0054 0.0154 0.0486
Entamoeba histolytica hypothetical protein 0.0038 0.0093 0.2517
Loa Loa (eye worm) hypothetical protein 0.0023 0.0032 0.0102
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Trichomonas vaginalis set domain proteins, putative 0.0943 0.3607 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.002 0.0064
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0087 0.0275
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0012 0.0012
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0048 0.0131 0.0414
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0369 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0023 0.0032 0.0102
Toxoplasma gondii hypothetical protein 0.0015 0.0004 0.0041
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0051 0.0141 0.0447
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Echinococcus granulosus RUN 0.002 0.002 0.002
Onchocerca volvulus 0.0015 0.0004 0.001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0018 0.0041
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.002 0.002
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0059 0.2286
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0093 0.0214
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0022
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0114 0.0388 0.0388
Echinococcus multilocularis expressed protein 0.0033 0.0073 0.0073
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0089 0.0089
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0089 0.0089
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.009 0.0221
Trichomonas vaginalis rotamase, putative 0.0033 0.0073 0.0173
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0275
Echinococcus granulosus expressed protein 0.0033 0.0073 0.0073
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.002 0.0062
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0369 1
Entamoeba histolytica hypothetical protein 0.0048 0.0131 0.3547
Onchocerca volvulus 0.0119 0.0408 0.1131
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0093 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0087 0.0275
Echinococcus multilocularis expressed protein 0.0746 0.2841 0.2841
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0016 0.0007 0.0007
Onchocerca volvulus 0.0017 0.0012 0.0032
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0194 0.1966
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0034
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0054 0.2061
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0048 0.0131 0.1432
Echinococcus granulosus voltage dependent calcium channel subunit 0.1178 0.4518 0.4518
Schistosoma mansoni aldehyde dehydrogenase 0.025 0.0914 0.211
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.002 0.0064
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0091 0.3717
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0408 0.0942
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0093 0.0093
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.025 0.0914 0.0914
Echinococcus granulosus leukotriene A 4 hydrolase 0.0231 0.084 0.084
Loa Loa (eye worm) hypothetical protein 0.004 0.01 0.0315
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.0093 0.0093
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0012 0.0037
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.0093 0.0093
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0048 0.0131 0.309
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0093 0.0093
Echinococcus granulosus metabotropic glutamate receptor 5 0.0109 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Onchocerca volvulus 0.0015 0.0004 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0089 0.0089
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0036 0.0398
Brugia malayi hypothetical protein 0.0037 0.0089 0.028
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0369 0.0852
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.002 0.002
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.007 0.1483
Echinococcus multilocularis cpg binding protein 0.003 0.0061 0.0061
Brugia malayi hypothetical protein 0.0033 0.0072 0.0226
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.002 0.0064
Onchocerca volvulus 0.0016 0.0007 0.0019
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.002 0.0064
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.009 0.366
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.002 0.002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0018 0.0077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0022
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0093 0.0214
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0914 1
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0087 0.0087
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0093 0.0093
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.002 0.0056
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0294
Onchocerca volvulus 0.0048 0.0131 0.0363
Brugia malayi EGF-like domain containing protein 0.0054 0.0154 0.0486
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.002 0.002
Onchocerca volvulus 0.0015 0.0004 0.001
Onchocerca volvulus 0.0015 0.0004 0.001
Schistosoma mansoni gabp alpha 0.0071 0.022 0.0508
Loa Loa (eye worm) CUTiclin-Like family member 0.0048 0.0131 0.0414
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0089 0.0089
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.002 0.002
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0131 0.3547
Loa Loa (eye worm) glutamate receptor 0.0089 0.0289 0.0913
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.002 0.002
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.0004 0.0041
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0054 0.017
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0406 0.152 0.351
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Brugia malayi von Willebrand Factor 0.0048 0.0131 0.0414
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0012 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0194 0.5014
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0007 0.0007
Schistosoma mansoni nAChR subunit 0.002 0.002 0.0046
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0089 0.2021
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.002 0.0064
Brugia malayi CXXC zinc finger family protein 0.0028 0.0055 0.0173
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0087 0.0201
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0018 0.0056
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.009 0.0221
Entamoeba histolytica hypothetical protein 0.0037 0.0089 0.2405
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.009 0.2061
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.002 0.0064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0093 0.0228
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.0093 0.0294
Toxoplasma gondii endonuclease IV APN 0.0075 0.0234 0.2561
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.3068 0.3068
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0062
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0007 0.0076
Schistosoma mansoni hypothetical protein 0.0037 0.0089 0.0205
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0084
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0087 0.0275
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0007 0.0016
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0007 0.0016
Mycobacterium ulcerans hypothetical protein 0.002 0.002 0.0107
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0196 0.0452
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0018 0.0041
Schistosoma mansoni metabotropic glutamate receptor 0.0043 0.0112 0.0259
Brugia malayi Bloom's syndrome protein homolog 0.004 0.0101 0.032
Onchocerca volvulus 0.002 0.002 0.0056
Brugia malayi hypothetical protein 0.0038 0.0093 0.0294
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0119 0.0408 0.0408
Schistosoma mansoni nAChR subunit 0.002 0.002 0.0046
Schistosoma mansoni hypothetical protein 0.0048 0.0131 0.0302
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0087 0.0087
Onchocerca volvulus 0.0015 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0087 0.0087
Echinococcus multilocularis geminin 0.0168 0.0597 0.0597
Onchocerca volvulus 0.0016 0.0007 0.0019
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.01 0.01
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0194 0.0613
Brugia malayi Protein kinase domain containing protein 0.0024 0.0036 0.0115
Brugia malayi Ets-domain containing protein 0.0071 0.022 0.0696
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.009 0.009
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0087 0.0087
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0868 0.0868
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.002 0.0064
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0087 0.0201
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0408 0.0942
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0087 0.0087
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0012 0.0027
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0012 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0292 0.1078 0.249
Toxoplasma gondii microneme protein MIC17A 0.0015 0.0004 0.0041
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0131 0.0414
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.0101 0.0252
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0062
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0194 0.0447
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0059 0.0134
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0012 0.0037
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0048 0.0131 0.5456
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0369 1
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0062
Schistosoma mansoni rab6-interacting 0.002 0.002 0.0046
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.007 0.0582
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0089 0.2402
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0087 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0087 0.0275
Schistosoma mansoni ap endonuclease 0.0038 0.009 0.0208
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0087 0.0201
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0141 0.3525
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0093 0.0294
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0157 0.0157
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0087 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0087 0.0275
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0117 0.0369
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0093 0.0093
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0004 0.0012
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0087 0.0275
Onchocerca volvulus 0.0016 0.0007 0.0019
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0012
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0012 0.0037
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0059 0.0644
Loa Loa (eye worm) fli-1 protein 0.0216 0.0782 0.2472
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0093 0.0214
Loa Loa (eye worm) glutamate receptor 0.0035 0.008 0.0252
Schistosoma mansoni polycystin 1-related 0.002 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0414
Brugia malayi PAN domain containing protein 0.0015 0.0004 0.0012
Onchocerca volvulus 0.0015 0.0004 0.001
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0048 0.0131 0.0131
Schistosoma mansoni ap endonuclease 0.0038 0.009 0.0208
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0093 0.0093
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0093 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0369 0.0996
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0064 0.0147
Loa Loa (eye worm) hypothetical protein 0.0037 0.0089 0.028
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0062
Onchocerca volvulus 0.0048 0.0131 0.0363
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0266 0.0842
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0359 0.083
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.002 0.0064
Toxoplasma gondii aldehyde dehydrogenase 0.025 0.0914 1
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0022
Echinococcus multilocularis musashi 0.0083 0.0266 0.0266
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0087 0.0087
Schistosoma mansoni ets-related 0.0216 0.0782 0.1805
Schistosoma mansoni aldehyde dehydrogenase 0.025 0.0914 0.211
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0296
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.007 0.0763
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.002 0.0326
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0012 0.0027
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0018 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0369 0.0996
Brugia malayi Cation transporter family protein 0.002 0.002 0.0064
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0255 0.0935 0.0935
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0018 0.0478
Onchocerca volvulus 0.0016 0.0007 0.0019
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0007 0.0016
Mycobacterium ulcerans epimerase 0.002 0.002 0.0107
Echinococcus granulosus slit 2 protein 0.0054 0.0154 0.0154
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0194 0.5014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0087 0.0275
Entamoeba histolytica hypothetical protein 0.0038 0.0093 0.2517
Brugia malayi Doublecortin family protein 0.002 0.002 0.0063
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.002 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0087 0.0275
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0093 0.0214
Brugia malayi ecdysone receptor 0.0017 0.0012 0.0037
Entamoeba histolytica hypothetical protein 0.0037 0.0089 0.2405
Echinococcus multilocularis serotonin transporter 0.0016 0.0007 0.0007
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0018 0.0056
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.002 0.0064
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.008 0.0256 0.081
Toxoplasma gondii microneme protein, putative 0.0015 0.0004 0.0041
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0369 1
Schistosoma mansoni hypothetical protein 0.0049 0.0133 0.0306
Loa Loa (eye worm) hypothetical protein 0.0107 0.0359 0.1136
Onchocerca volvulus 0.002 0.002 0.0056
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0087 0.0275
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0004 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.002 0.0062
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.002 0.0064
Loa Loa (eye worm) ACC-1 protein 0.002 0.002 0.0064
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0093 0.0214
Entamoeba histolytica hypothetical protein 0.0037 0.0089 0.2405
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0093 0.0214
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0087 0.0275
Brugia malayi nuclear receptor NHR-88 0.0017 0.0012 0.0037
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.002 0.0064
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0275
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0007 0.0016
Loa Loa (eye worm) ACC-1 protein 0.002 0.002 0.0064
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0093 0.0214
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0064
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0131 0.0414
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0087 0.0201
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0131 0.3547
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0093 0.0214
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.002 0.0064
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0054 0.0154 0.0486
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0093 0.0294
Schistosoma mansoni lamin 0.0083 0.0266 0.0615
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0089 0.0217
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0101 0.0252
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0063
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.002 0.002
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0093 0.0214
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0143 0.033
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0037
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0157 0.0157
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0012 0.0012
Echinococcus granulosus neurogenic locus notch protein 0.0054 0.0154 0.0154
Trichomonas vaginalis rotamase, putative 0.0032 0.007 0.0164
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.002 0.002
Brugia malayi nuclear hormone receptor 0.0037 0.0087 0.0275
Mycobacterium ulcerans aldehyde dehydrogenase 0.025 0.0914 1

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 100 uM Concentration required to cause 50% death of uninfected MT-4 cells ChEMBL. 9871669
CC50 (functional) > 100 uM Concentration required to cause 50% death of uninfected MT-4 cells ChEMBL. 9871669
IC50 (functional) = 0.1 uM Concentration required to inhibit syncitia formation by 50% in HIV infected HIV-BRU MT-4 cells ChEMBL. 9871669
IC50 (functional) = 0.1 uM Concentration required to inhibit syncitia formation by 50% in HIV infected HIV-BRU MT-4 cells ChEMBL. 9871669
logP (ADMET) = 2.31 Partition coefficient (logP) ChEMBL. 9871669

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9871669

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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