Detailed information for compound 1611115

Basic information

Technical information
  • TDR Targets ID: 1611115
  • Name: 2-chloro-3-ethylaminonaphthalene-1,4-dione
  • MW: 235.666 | Formula: C12H10ClNO2
  • H donors: 1 H acceptors: 2 LogP: 2.85 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC1=C(Cl)C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C12H10ClNO2/c1-2-14-10-9(13)11(15)7-5-3-4-6-8(7)12(10)16/h3-6,14H,2H2,1H3
  • InChiKey: XBADMYUFDWBDLJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-chloro-3-ethylamino-naphthalene-1,4-dione
  • 2-chloro-3-ethylamino-1,4-naphthoquinone
  • 5349-87-1
  • ST5430593
  • 2-chloro-3-(ethylamino)naphthoquinone
  • MLS000533469
  • SMR000140907
  • NSC3860

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens microphthalmia-associated transcription factor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni Replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB Get druggable targets OG5_131890 All targets in OG5_131890
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Chlamydia trachomatis replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Helix-loop-helix DNA-binding domain containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Mycobacterium ulcerans replicative DNA helicase DnaB Get druggable targets OG5_131890 All targets in OG5_131890
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Treponema pallidum replicative DNA helicase (dnaB) Get druggable targets OG5_131890 All targets in OG5_131890
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133408 All targets in OG5_133408
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, unknown function 0.0017 0.0002 0.0005
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0467 0.2182 1
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Onchocerca volvulus 0.0039 0.0107 0.0232
Loa Loa (eye worm) Smad1 0.0025 0.0042 0.009
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0077 0.0169
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0224 0.0222
Loa Loa (eye worm) hypothetical protein 0.0336 0.1549 0.344
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0025 0.0023
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0306 0.0677
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0224 0.0495
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0042 0.0041
Schistosoma mansoni peter pan-related 0.0017 0.0002 0.0001
Schistosoma mansoni microtubule-associated protein tau 0.1443 0.6915 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.0059
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0017 0.0002 0.0001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0025 0.0023
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0017 0.0002 0.0001
Leishmania major hypothetical protein, conserved 0.0336 0.1549 0.9175
Schistosoma mansoni hypothetical protein 0.0945 0.4499 0.6505
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0004 0.0002
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Brugia malayi Cytochrome P450 family protein 0.0025 0.0042 0.0094
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.1631 0.7462
Schistosoma mansoni tar DNA-binding protein 0.0076 0.029 0.0418
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0048 0.015 0.0149
Brugia malayi hypothetical protein 0.0314 0.1442 0.3205
Brugia malayi hypothetical protein 0.0043 0.013 0.0289
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1688 1
Echinococcus multilocularis Smad4 0.0025 0.0042 0.0041
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0214 0.0473
Loa Loa (eye worm) hypothetical protein 0.018 0.0794 0.1762
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0235 0.1037
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0224 0.0322
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0021 0.0046
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0371 0.172 0.382
Brugia malayi brahma associated protein 60 kDa 0.0945 0.4499 1
Echinococcus multilocularis microtubule associated protein 2 0.1443 0.6915 0.6915
Echinococcus granulosus microtubule associated protein 2 0.1443 0.6915 0.6915
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0233
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0306 0.1805
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0336 0.1549 0.1547
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Brugia malayi YY1-associated factor 2 0.0336 0.1549 0.3442
Echinococcus multilocularis Protein lozenge 0.0067 0.0245 0.0243
Echinococcus granulosus GPCR family 2 0.0051 0.0169 0.0167
Leishmania major hypothetical protein, conserved 0.0026 0.0044 0.0252
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0017 0.0002 0.000000027766
Brugia malayi hypothetical protein 0.0238 0.1073 0.2386
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0044 0.0094
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0075 0.0283 0.0281
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0107 0.0232
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0224 0.0222
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0048 0.015 0.0882
Echinococcus multilocularis dnaJ subfamily B 0.0866 0.4119 0.4118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0224 0.0322
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0017 0.0002 0.0005
Loa Loa (eye worm) TAR-binding protein 0.0076 0.029 0.0642
Trypanosoma brucei ring finger containing protein 0.0017 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0051 0.0169 0.0242
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0235 0.0519
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0042 0.009
Echinococcus multilocularis ring finger protein 170 0.0017 0.0002 0.0001
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Schistosoma mansoni ap endonuclease 0.0019 0.001 0.0012
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0107 0.0105
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0004 0.0002
Schistosoma mansoni fusion 0.0336 0.1549 0.2238
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0042 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0005
Echinococcus multilocularis neuropeptide receptor A26 0.0496 0.2322 0.2321
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0022 0.002
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0235 0.0234
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0336 0.1549 0.1547
Echinococcus multilocularis geminin 0.0182 0.08 0.0798
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.015 0.0329
Trypanosoma brucei hypothetical protein, conserved 0.0336 0.1549 0.9175
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0044 0.0094
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Echinococcus granulosus zinc finger protein Ran binding 0.0336 0.1549 0.1547
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0042 0.0242
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0048 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0336 0.1549 0.344
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0048 0.015 0.0215
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0004 0.0002
Plasmodium vivax RING zinc finger protein, putative 0.0017 0.0002 0.0002
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0756 0.4476
Mycobacterium ulcerans beta-lactamase 0.0039 0.0107 0.0446
Loa Loa (eye worm) hypothetical protein 0.0051 0.0169 0.0372
Plasmodium vivax zinc finger protein, putative 0.0017 0.0002 0.0002
Echinococcus granulosus geminin 0.0182 0.08 0.0798
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Chlamydia trachomatis DNA topoisomerase I 0.0945 0.4499 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Onchocerca volvulus Huntingtin homolog 0.0148 0.0637 0.1411
Onchocerca volvulus 0.0945 0.4499 1
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0025 0.0034
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1631 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0155 0.0222
Schistosoma mansoni hypothetical protein 0.0182 0.08 0.1155
Onchocerca volvulus 0.0061 0.0214 0.0471
Onchocerca volvulus Huntingtin homolog 0.0148 0.0637 0.1411
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0044 0.0252
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0107 0.0237
Leishmania major hypothetical protein, conserved 0.0039 0.0107 0.0623
Echinococcus granulosus cell growth regulator with ring finger domain 0.0017 0.0002 0.0001
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0051 0.0169 0.0242
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0945 0.4499 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.015 0.0882
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0044 0.0094
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0025 0.0034
Trichomonas vaginalis esterase, putative 0.0039 0.0107 0.0232
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0945 0.4499 1
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.1073 0.1072
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Onchocerca volvulus 0.0314 0.1442 0.3201
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0017 0.0002 0.0005
Treponema pallidum replicative DNA helicase (dnaB) 0.0467 0.2182 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0336 0.1549 0.3442
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.001 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1631 0.3621
Onchocerca volvulus 0.0049 0.0155 0.0339
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0235 0.0338
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0489 0.2291 0.509
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0107 0.0105
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0077 0.0172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1631 0.3621
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0002 0.0001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.043 0.2004 0.4453
Loa Loa (eye worm) hypothetical protein 0.0336 0.1549 0.344
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.013 0.0186
Schistosoma mansoni hypothetical protein 0.0182 0.08 0.1155
Brugia malayi hypothetical protein 0.0017 0.0002 0.0005
Giardia lamblia Kinase, NEK 0.0017 0.0002 0.000000076678
Schistosoma mansoni tar DNA-binding protein 0.0076 0.029 0.0418
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0169 0.0372
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.001 0.0018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0224 0.0222
Plasmodium vivax trophozoite exported protein 1, putative 0.0017 0.0002 0.0002
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0017 0.0002 0.0002
Trichomonas vaginalis ankyrin, putative 0.0017 0.0002 0.000000027766
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0235 0.0233
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0306 0.1864
Brugia malayi Pre-SET motif family protein 0.043 0.2004 0.4455
Echinococcus multilocularis RING finger protein 185 0.0017 0.0002 0.0001
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.001 0.0021
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.013 0.0548 0.1216
Brugia malayi hypothetical protein 0.0535 0.2513 0.5585
Echinococcus granulosus transcription factor eb 0.013 0.0552 0.055
Onchocerca volvulus 0.0535 0.2513 0.5583
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0336 0.1549 0.9175
Trypanosoma brucei predicted zinc finger protein 0.0017 0.0002 0.0005
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0052
Schistosoma mansoni cpg binding protein 0.0061 0.0214 0.0308
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1631 1
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.1073 0.1072
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0259 0.0571
Mycobacterium tuberculosis Conserved protein 0.0039 0.0107 0.0105
Plasmodium vivax hypothetical protein, conserved 0.0945 0.4499 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0107 0.0232
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0017 0.0002 0.0002
Loa Loa (eye worm) RiNg Finger protein family member 0.0017 0.0003 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0235 0.1037
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0048 0.015 0.0909
Brugia malayi brahma associated protein 60 kDa 0.0945 0.4499 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Schistosoma mansoni intermediate filament proteins 0.0033 0.0077 0.011
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Echinococcus granulosus intermediate filament protein 0.0033 0.0077 0.0076
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0017 0.0002 0.0002
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0048 0.015 0.0334
Loa Loa (eye worm) twinkle helicase 0.0133 0.0566 0.1255
Schistosoma mansoni hypothetical protein 0.0049 0.0155 0.0222
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.001 0.0048
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.0059
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.013 0.0129
Onchocerca volvulus 0.0039 0.0107 0.0232
Onchocerca volvulus 0.0489 0.2291 0.509
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0316 0.0455
Onchocerca volvulus 0.0033 0.0077 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0336 0.1549 0.9175
Trypanosoma brucei DNA repair protein, putative 0.0017 0.0002 0.0005
Echinococcus granulosus ubiquitin specific protease 41 0.0048 0.015 0.0149
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0223 0.131
Loa Loa (eye worm) hypothetical protein 0.018 0.0794 0.1762
Echinococcus multilocularis muscleblind protein 1 0.018 0.0794 0.0793
Echinococcus multilocularis ring and YY1 binding protein 0.0336 0.1549 0.1547
Echinococcus multilocularis ubiquitin specific protease 41 0.0048 0.015 0.0149
Toxoplasma gondii hypothetical protein 0.0017 0.0002 0.0002
Trichomonas vaginalis ankyrin, putative 0.0017 0.0002 0.000000027766
Schistosoma mansoni TRABID protein (C64 family) 0.0336 0.1549 0.2238
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0042 0.0041
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0169 0.0167
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0756 0.4476
Brugia malayi MH1 domain containing protein 0.0025 0.0042 0.0094
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0042 0.0091
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0017 0.0003 0.0001
Onchocerca volvulus 0.0063 0.0224 0.0493
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0556 0.0802
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0107 0.0233
Brugia malayi Cytochrome P450 family protein 0.0025 0.0042 0.0094
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.0059
Mycobacterium ulcerans hypothetical protein 0.0039 0.0107 0.0446
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0017 0.0002 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0005
Schistosoma mansoni cpg binding protein 0.0064 0.0231 0.0332
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1612 0.7733 0.7736
Brugia malayi RNA binding protein 0.0076 0.029 0.0646
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0048 0.015 0.0215
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0306 0.1805
Mycobacterium tuberculosis Conserved protein 0.0039 0.0107 0.0105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0107 0.0152
Leishmania major hypothetical protein, conserved 0.0336 0.1549 0.9175
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0075 0.0283 0.0281
Echinococcus granulosus Smad4 0.0025 0.0042 0.0041
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0306 0.0304
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0042 0.0041
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0017 0.0002 0.0001
Entamoeba histolytica hypothetical protein 0.0043 0.013 0.0785
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0169 0.0167
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.001 0.0016
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0017 0.0002 0.0002
Trichomonas vaginalis ankyrin, putative 0.0017 0.0002 0.000000027766
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.029 0.0642
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0306 0.1805
Loa Loa (eye worm) hypothetical protein 0.0336 0.1549 0.344
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Loa Loa (eye worm) hypothetical protein 0.0148 0.0637 0.1412
Toxoplasma gondii hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0076 0.029 0.0418
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0306 0.068
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0336 0.1549 0.3442
Schistosoma mansoni hypothetical protein 0.0945 0.4499 0.6505
Toxoplasma gondii exonuclease III APE 0.0019 0.001 0.0018
Brugia malayi Neuralized family protein 0.0017 0.0002 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.013 0.0129
Loa Loa (eye worm) hypothetical protein 0.0148 0.0637 0.1412
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0042 0.0091
Echinococcus multilocularis musashi 0.0033 0.0077 0.0076
Trypanosoma cruzi hypothetical protein 0.0017 0.0002 0.0005
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0945 0.4499 1
Schistosoma mansoni hypothetical protein 0.0111 0.0458 0.066
Brugia malayi Zinc finger, C2H2 type family protein 0.0017 0.0002 0.0005
Brugia malayi hypothetical protein 0.0017 0.0002 0.0005
Brugia malayi MH2 domain containing protein 0.0371 0.172 0.3823
Loa Loa (eye worm) hypothetical protein 0.0111 0.0458 0.1015
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Echinococcus multilocularis transcription factor eb 0.013 0.0552 0.055
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0235 0.0233
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0168 0.0988
Loa Loa (eye worm) hypothetical protein 0.0535 0.2513 0.5583
Toxoplasma gondii ran binding protein 0.0336 0.1549 0.344
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Schistosoma mansoni ring finger protein 151 0.0017 0.0002 0.0001
Echinococcus multilocularis zinc finger protein Ran binding 0.0336 0.1549 0.1547
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0012
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0017 0.0002 0.000000027766
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0022 0.0045
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0143 0.0142
Brugia malayi RING zinc finger protein 0.0017 0.0002 0.0005
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0467 0.2182 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Echinococcus granulosus muscleblind protein 0.018 0.0794 0.0793
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.001 0.0044
Schistosoma mansoni hypothetical protein 0.0866 0.4119 0.5955
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.029 0.0646
Mycobacterium tuberculosis Conserved protein 0.0039 0.0107 0.0105
Toxoplasma gondii ABC1 family protein 0.0039 0.0107 0.0233
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0002
Echinococcus granulosus Zinc finger RanBP2 type 0.0336 0.1549 0.1547
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Brugia malayi MH2 domain containing protein 0.0025 0.0042 0.0094
Toxoplasma gondii hypothetical protein 0.0017 0.0002 0.0002
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Plasmodium vivax SET domain protein, putative 0.0063 0.0224 0.0495
Brugia malayi MH1 domain containing protein 0.0025 0.0042 0.0094
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1688 1
Brugia malayi hypothetical protein 0.0017 0.0002 0.0005
Echinococcus granulosus lamin dm0 0.0033 0.0077 0.0076
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.1688 1
Echinococcus multilocularis GPCR, family 2 0.0051 0.0169 0.0167
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0945 0.4499 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0044 0.0252
Brugia malayi hypothetical protein 0.0017 0.0002 0.0005
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Echinococcus granulosus ring finger protein 170 0.0017 0.0002 0.0001
Echinococcus multilocularis SWI:SNF matrix associated 0.0945 0.4499 0.4498
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.001 0.0016
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Schistosoma mansoni zinc finger protein 0.0017 0.0002 0.0001
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0048 0.015 0.0909
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0107 0.0105
Loa Loa (eye worm) RING finger protein 20 0.0017 0.0002 0.0002
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.001 0.0048
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0155 0.0344
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0169 0.0167
Loa Loa (eye worm) beta-lactamase 0.0039 0.0107 0.0233
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0107 0.0152
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0169 0.0167
Echinococcus multilocularis ring finger protein 113a 0.0017 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.0001
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0467 0.2182 0.7472
Brugia malayi CXXC zinc finger family protein 0.0061 0.0214 0.0477
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.1631 1
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0235 0.1037
Plasmodium falciparum RING zinc finger protein, putative 0.0017 0.0002 0.0002
Echinococcus multilocularis lamin 0.0033 0.0077 0.0076
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.001 0.0008
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0025 0.0023
Brugia malayi B-box zinc finger family protein 0.0017 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0075 0.0283 0.0629
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0005
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0107 0.0105
Schistosoma mansoni peter pan-related 0.0017 0.0002 0.0001
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0336 0.1549 0.9175
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0336 0.1549 0.9175
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0017 0.0002 0.0001
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0756 0.0754
Schistosoma mansoni hypothetical protein 0.0945 0.4499 0.6505
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0107 0.0623
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.015 0.0882
Loa Loa (eye worm) hypothetical protein 0.0048 0.015 0.0331
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0048 0.015 0.0149
Toxoplasma gondii helicase, putative 0.0017 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0076 0.029 0.0418
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.0707 0.1569
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0336 0.1549 0.1547
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.0707 0.1572
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Loa Loa (eye worm) hypothetical protein 0.0238 0.1073 0.2383
Brugia malayi Muscleblind-like protein 0.018 0.0794 0.1765
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0489 0.1084
Schistosoma mansoni ap endonuclease 0.0019 0.001 0.0012
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0336 0.1549 0.344
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1631 0.3621
Echinococcus granulosus smad 0.0025 0.0042 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0005
Trypanosoma cruzi hypothetical protein 0.0017 0.0002 0.0005
Mycobacterium leprae Conserved hypothetical protein 0.0612 0.2884 1
Brugia malayi hypothetical protein 0.0017 0.0002 0.0005
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0945 0.4499 1
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0235 0.0519
Loa Loa (eye worm) hypothetical protein 0.0336 0.1549 0.344
Brugia malayi Pre-SET motif family protein 0.0063 0.0224 0.0498
Giardia lamblia Ser/Thr protein kinase 0.0017 0.0002 0.000000076678
Trypanosoma cruzi hypothetical protein, conserved 0.0336 0.1549 0.9175
Onchocerca volvulus 0.0336 0.1549 0.3438
Brugia malayi beta-lactamase family protein 0.0039 0.0107 0.0237
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0336 0.1549 0.9175
Loa Loa (eye worm) runx1 0.0067 0.0245 0.0541
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0107 0.0623
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0075 0.0283 0.0626
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0017 0.0002 0.000000027766
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Brugia malayi Zinc finger protein 183 homolog 0.0017 0.0003 0.0007
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0945 0.4499 0.4498
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0336 0.1549 0.9175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1631 0.3621
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0306 0.044
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0107 0.0446
Trypanosoma cruzi WLM domain containing protein, putative 0.0336 0.1549 0.9175
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0094
Toxoplasma gondii hypothetical protein 0.0017 0.0002 0.0002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0207 0.0205
Trypanosoma cruzi hypothetical protein, conserved 0.0336 0.1549 0.9175
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0017 0.0002 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0022 0.002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.015 0.0329
Loa Loa (eye worm) hypothetical protein 0.0033 0.0077 0.0169
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0851 0.085
Brugia malayi intermediate filament protein 0.0033 0.0077 0.0172
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0017 0.0002 0.0002
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.1688 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.001 0.0008
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0048 0.015 0.0149
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0143 0.0142
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0017 0.0002 0.0001
Schistosoma mansoni lozenge 0.0067 0.0245 0.0352
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0107 0.0232
Entamoeba histolytica hypothetical protein 0.0043 0.013 0.0785
Schistosoma mansoni hypothetical protein 0.0051 0.0169 0.0242
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0336 0.1549 0.3438
Echinococcus multilocularis smad 0.0025 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1631 0.3621
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0017 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0233
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Brugia malayi Smad1 0.0025 0.0042 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.0707 0.1572
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.001 0.0044
Loa Loa (eye worm) hypothetical protein 0.0304 0.1395 0.3098
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0233
Brugia malayi beta-lactamase family protein 0.0039 0.0107 0.0237
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0107 0.0232
Brugia malayi isocitrate dehydrogenase 0.0017 0.0002 0.0004
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0107 0.0446
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0025 0.0055
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0168 0.0988
Echinococcus multilocularis SWI:SNF matrix associated 0.0945 0.4499 0.4498
Loa Loa (eye worm) hypothetical protein 0.0063 0.0224 0.0495
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0044 0.0094
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0017 0.0002 0.0005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0107 0.0105
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.1115 0.1114
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0233
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0869 0.4132 0.4131
Echinococcus multilocularis muscleblind protein 0.018 0.0794 0.0793
Trypanosoma brucei hypothetical protein, conserved 0.0336 0.1549 0.9175
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Echinococcus granulosus lamin 0.0033 0.0077 0.0076
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.015 0.0882
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0005
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0336 0.1549 0.344
Toxoplasma gondii hypothetical protein 0.0059 0.0205 0.0452
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.001 0.0018
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0077 0.0169
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0017 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0107 0.0233
Onchocerca volvulus 0.0039 0.0107 0.0232
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0017 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0336 0.1549 0.2238
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0002 0.0004
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0004 0.0002
Schistosoma mansoni rnf5 0.0017 0.0002 0.0001
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Echinococcus granulosus SWI:SNF matrix associated 0.0945 0.4499 0.4498
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0306 0.1805
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Echinococcus multilocularis cpg binding protein 0.0064 0.0231 0.023
Mycobacterium ulcerans lipase LipD 0.0039 0.0107 0.0446
Brugia malayi beta-lactamase 0.0039 0.0107 0.0237
Entamoeba histolytica hypothetical protein 0.0043 0.013 0.0785
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0002 0.0005
Trypanosoma cruzi WLM domain containing protein, putative 0.0336 0.1549 0.9175
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1631 0.3621
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.2078 0.9995 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.015 0.0329
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0107 0.0105
Brugia malayi TAR-binding protein 0.0076 0.029 0.0646
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0107 0.0105
Onchocerca volvulus 0.0336 0.1549 0.3438
Schistosoma mansoni Replicative DNA helicase 0.0467 0.2182 0.3154
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0107 0.0623
Leishmania major hypothetical protein, conserved 0.0336 0.1549 0.9175
Leishmania major cytochrome p450-like protein 0.0025 0.0042 0.0242
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0336 0.1549 0.3442
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.001 0.0018
Leishmania major hypothetical protein 0.0017 0.0002 0.0005
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Schistosoma mansoni lamin 0.0033 0.0077 0.011
Schistosoma mansoni cellular tumor antigen P53 0.0304 0.1395 0.2015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0107 0.0233
Schistosoma mansoni brg-1 associated factor 0.0945 0.4499 0.6505
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0017 0.0002 0.0001
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0336 0.1549 0.9175
Loa Loa (eye worm) hypothetical protein 0.0314 0.1442 0.3202
Schistosoma mansoni RNA binding protein 0.0336 0.1549 0.2238
Leishmania major hypothetical protein, conserved 0.0336 0.1549 0.9175
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0017 0.0002 0.000000027766
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0259 0.0571
Leishmania major hypothetical protein, conserved 0.0336 0.1549 0.9175
Echinococcus multilocularis tumor protein p63 0.2079 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0169 0.0375
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0017 0.0002 0.0001
Loa Loa (eye worm) RNA binding protein 0.0076 0.029 0.0642
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0004 0.0006
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0017 0.0002 0.0001
Entamoeba histolytica hypothetical protein 0.0043 0.013 0.0785
Schistosoma mansoni zinc finger protein 0.0336 0.1549 0.2238
Onchocerca volvulus 0.0033 0.0077 0.0167
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0042 0.0059
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Loa Loa (eye worm) hypothetical protein 0.0535 0.2513 0.5583
Echinococcus granulosus ring and YY1 binding protein 0.0336 0.1549 0.1547
Echinococcus granulosus RING finger protein 185 0.0017 0.0002 0.0001
Plasmodium vivax DNA repair protein RAD5, putative 0.0017 0.0002 0.0002
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Leishmania major DNA repair protein-like protein 0.0017 0.0002 0.0005
Echinococcus granulosus dnaJ subfamily B 0.0866 0.4119 0.4118
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0004 0.0009
Echinococcus granulosus neuropeptide receptor A26 0.0496 0.2322 0.2321
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.013 0.0552 0.1226
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1631 0.3621
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0224 0.0322
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0044 0.0252
Chlamydia trachomatis SWIB complex protein 0.0945 0.4499 1
Schistosoma mansoni mind bomb 0.0017 0.0002 0.0001
Brugia malayi hypothetical protein 0.0148 0.0637 0.1415
Echinococcus granulosus cpg binding protein 0.0064 0.0231 0.023
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0336 0.1549 0.3442
Loa Loa (eye worm) transcription factor SMAD2 0.0371 0.172 0.382
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0945 0.4499 0.4498
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0017 0.0002 0.0001
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0042 0.0242
Echinococcus granulosus ring finger protein 113a 0.0017 0.0003 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0042 0.0091
Loa Loa (eye worm) hypothetical protein 0.013 0.0548 0.1216
Brugia malayi SWIB/MDM2 domain containing protein 0.0945 0.4499 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0945 0.4499 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0004 0.0003
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0042 0.0242
Trichomonas vaginalis ion channel nompc, putative 0.0017 0.0002 0.000000027766
Loa Loa (eye worm) brahma associated protein 0.0945 0.4499 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0107 0.0105
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0945 0.4499 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0756 0.2336
Schistosoma mansoni hypothetical protein 0.0043 0.013 0.0186
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0168 0.0988
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0042 0.009
Mycobacterium ulcerans hypothetical protein 0.0192 0.0851 0.3873
Leishmania major hypothetical protein, conserved 0.0017 0.0002 0.0005
Echinococcus granulosus neuropeptide s receptor 0.0496 0.2322 0.2321
Loa Loa (eye worm) hypothetical protein 0.0163 0.0707 0.1569
Onchocerca volvulus 0.0336 0.1549 0.3438
Echinococcus multilocularis 0.0017 0.0002 0.0001
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0756 0.3433
Plasmodium falciparum zinc finger protein, putative 0.0017 0.0002 0.0002
Echinococcus granulosus tar DNA binding protein 0.0076 0.029 0.0289
Toxoplasma gondii RING zinc finger protein 0.0017 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0224 0.0322
Brugia malayi hypothetical protein 0.0026 0.0044 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0076 0.029 0.0418
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0107 0.0232
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0458 0.1018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0162
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0169 0.0375
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0168 0.0988
Brugia malayi MH2 domain containing protein 0.0025 0.0042 0.0094
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0756 0.4476
Echinococcus multilocularis lamin dm0 0.0033 0.0077 0.0076
Giardia lamblia Protein 21.1 0.0017 0.0002 0.000000076678
Echinococcus multilocularis neuropeptide s receptor 0.0496 0.2322 0.2321
Schistosoma mansoni Smad4 0.0025 0.0042 0.0059
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0017 0.0002 0.0005
Schistosoma mansoni smad 0.0025 0.0042 0.0059
Onchocerca volvulus 0.0336 0.1549 0.3438
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0017 0.0002 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1631 0.3621
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.001 0.0048
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0107 0.0105
Schistosoma mansoni cpg binding protein 0.0064 0.0231 0.0332
Brugia malayi RING finger protein 20 0.0017 0.0002 0.0005
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0042 0.0041
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0306 0.0304
Plasmodium falciparum trophozoite exported protein 1 0.0017 0.0002 0.0002
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0002 0.0005
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0235 0.1384
Onchocerca volvulus 0.0304 0.1395 0.3097
Echinococcus multilocularis SWI:SNF matrix associated 0.0945 0.4499 0.4498
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0316 0.0455
Schistosoma mansoni hypothetical protein 0.0051 0.0169 0.0242
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0235 0.0338
Brugia malayi hypothetical protein 0.0017 0.0002 0.0005
Echinococcus multilocularis tar DNA binding protein 0.0076 0.029 0.0289
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0336 0.1549 0.9175
Schistosoma mansoni lamin 0.0033 0.0077 0.011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.001 0.0008

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 3.839 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 3.839 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 3.839 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 6.983 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
AC50 (functional) = 9.435 uM PUBCHEM_BIOASSAY: MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_CherryPick_Activity_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 15.313 uM PUBCHEM_BIOASSAY: MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 22.29 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
EC50 (functional) = 20 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2097, AID2223, AID489010, AID492950] ChEMBL. No reference
EC50 (functional) > 103.909 uM PUBCHEM_BIOASSAY: Absorbance-based biochemical high throughput dose response assay for activators of Methionine sulfoxide reductase A (MsrA). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 50 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Calpain Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1236 (Primary screen preceding this confirmatory assay.)] ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8117 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation with Orthogonal Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 7.9433 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1477, AID1484] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: ME-1 cellular proliferation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1477, AID1484] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.