Detailed information for compound 1617234

Basic information

Technical information
  • TDR Targets ID: 1617234
  • Name: [4-bromo-2-[[[2-(4-tert-butylphenoxy)acetyl]h ydrazinylidene]methyl]phenyl] furan-2-carboxy late
  • MW: 499.354 | Formula: C24H23BrN2O5
  • H donors: 1 H acceptors: 2 LogP: 6.04 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1ccc(cc1)C(C)(C)C)N/N=C/c1cc(Br)ccc1OC(=O)c1ccco1
  • InChi: 1S/C24H23BrN2O5/c1-24(2,3)17-6-9-19(10-7-17)31-15-22(28)27-26-14-16-13-18(25)8-11-20(16)32-23(29)21-5-4-12-30-21/h4-14H,15H2,1-3H3,(H,27,28)/b26-14+
  • InChiKey: KKNZPYUITYVVIJ-VULFUBBASA-N  


Substructure search Similarity search

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Synonyms

  • [4-bromo-2-[(E)-[[2-(4-tert-butylphenoxy)acetyl]hydrazinylidene]methyl]phenyl] furan-2-carboxylate
  • [4-bromo-2-[[[2-(4-tert-butylphenoxy)acetyl]hydrazono]methyl]phenyl] furan-2-carboxylate
  • [4-bromo-2-[(E)-[[2-(4-tert-butylphenoxy)acetyl]hydrazono]methyl]phenyl] furan-2-carboxylate
  • 2-furancarboxylic acid [4-bromo-2-[(E)-[[2-(4-tert-butylphenoxy)-1-oxoethyl]hydrazono]methyl]phenyl] ester
  • 2-furancarboxylic acid [4-bromo-2-[[[2-(4-tert-butylphenoxy)-1-oxoethyl]hydrazono]methyl]phenyl] ester
  • furan-2-carboxylic acid [4-bromo-2-[[[2-(4-tert-butylphenoxy)acetyl]hydrazono]methyl]phenyl] ester
  • furan-2-carboxylic acid [4-bromo-2-[(E)-[[2-(4-tert-butylphenoxy)acetyl]hydrazono]methyl]phenyl] ester
  • [4-bromo-2-[[2-(4-tert-butylphenoxy)ethanoylhydrazinylidene]methyl]phenyl] furan-2-carboxylate
  • [4-bromo-2-[(E)-[2-(4-tert-butylphenoxy)ethanoylhydrazinylidene]methyl]phenyl] furan-2-carboxylate
  • SMR000174290
  • BAS 00292107
  • Furan-2-carboxylic acid 4-bromo-2-{[2-(4-tert-butyl-phenoxy)-acetyl]-hydrazonomethyl}-phenyl ester
  • MLS000561322

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0013 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0188 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Trypanosoma cruzi cysteine protease, putative 0.001 0.0009 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.6071
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0013 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0013 0.001
Leishmania major cytochrome p450-like protein 0.0009 0.0004 0.0021
Loa Loa (eye worm) cysteine protease 0.002 0.0035 0.0032
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0013 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0013 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0013 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0035 0.0426
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0017 0.0185
Onchocerca volvulus 0.002 0.0035 0.0426
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0035 0.0426
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0058 1
Leishmania major cathepsin L-like protease 0.002 0.0035 0.1721
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.3716 0.9985 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0129 0.0126
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0013 0.001
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0009 0.0004 0.007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0129 0.0126
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0009 0.0018
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0009 0.0018
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0009 0.0004 0.007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0013 0.001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0058 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0749 0.0746
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0129 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0009 0.0004 0.0612
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0188 0.0614
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0035 0.0032
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0009 0.0004 0.007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0013 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0035 0.0426
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0013 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.001
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0013 0.001
Mycobacterium leprae putative cytochrome p450 0.0009 0.0004 0.007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0009 0.0005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0013 0.001
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0058 0.0054
Schistosoma mansoni hypothetical protein 0.0058 0.0137 0.0134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0035 0.0426
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0058 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0013 0.001
Echinococcus granulosus cathepsin l1 0.0014 0.0017 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0013 0.001
Brugia malayi Cathepsin L-like precursor 0.002 0.0035 0.0032
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0009 0.0004 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0188 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0074 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.0035
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0009 0.0005
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0035 0.0032
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0013 0.001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0013 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0013 0.001
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0009 0.0004 0.007
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0035 0.0032
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0009 0.0004 0.007
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0013 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0035 0.0106
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0013 0.001
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0035 0.0032
Onchocerca volvulus Cathepsin F homolog 0.002 0.0035 0.0426
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Brugia malayi cathepsin L-like precursor 0.0014 0.0017 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0009 0.0004 0.0612
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0009 0.0994
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.001
Schistosoma mansoni survival motor neuron protein 0.0058 0.0137 0.0134
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0013 0.001
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0017 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0017 0.2536
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0035 0.0032
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0009 0.0004 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0003 0.0546
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0003 0.0546
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0035 0.5841
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0188 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0137 0.0134
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0751 1
Onchocerca volvulus 0.0182 0.0472 0.627
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0058 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0038 0.6617
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0013 0.001
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0035 0.9097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.0035
Plasmodium vivax vivapain-2 0.002 0.0035 0.4274
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0058 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0009 0.0004 0.0612
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0009 0.0004 0.007
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0749 0.0746
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0038 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0013 0.001
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Brugia malayi Pre-SET motif family protein 0.0251 0.0657 0.0654
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.001
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0009 0.0994
Brugia malayi Cathepsin L-like precursor 0.002 0.0035 0.0032
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0009 0.0004 0.007
Leishmania major cathepsin L-like protease 0.002 0.0035 0.1721
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0013 0.001
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0055
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0009 0.1548
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0013 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0017 0.0185
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0055
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.1126 0.3012 0.3015
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0003 0.0546
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0129 0.0126
Onchocerca volvulus 0.002 0.0035 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.6071
Plasmodium vivax SET domain protein, putative 0.0036 0.0078 1
Plasmodium vivax vivapain-2 0.002 0.0035 0.4274
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0009 0.0004 0.0612
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0009 0.0994
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0003 0.0546
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0009 0.0004 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0188 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0035 0.0426
Brugia malayi Cathepsin L-like precursor 0.0014 0.0017 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0078 0.0074
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0078 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0013 0.001
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0003 0.0546
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0035 0.0032
Brugia malayi hypothetical protein 0.0182 0.0472 0.0469
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0009 0.0004 0.0612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0035 0.0426
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0013 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0129 0.0126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0129 0.0126
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.017 0.0554
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0009 0.0018
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0013 0.001
Leishmania major cytochrome p450-like protein 0.0009 0.0004 0.0021
Leishmania major cathepsin L-like protease 0.0077 0.0188 1
Brugia malayi nuclear receptor NHR-88 0.0012 0.0013 0.001
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1126 0.3012 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0009 0.0004 0.007
Echinococcus granulosus cysteine protease 0.001 0.0009 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0009 0.0994
Echinococcus granulosus cathepsin L 0.001 0.0009 0.0005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0078 0.0074
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0038 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0013 0.001
Toxoplasma gondii cytochrome p450 superfamily protein 0.0009 0.0004 0.0051
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0009 0.0004 0.007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0013 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0058 0.2947
Plasmodium vivax vivapain-1 0.001 0.0009 0.0727
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0013 0.001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0038 0.6421
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0003 0.0546
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0004 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0066 0.0063
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0038 0.4698
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.6071
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0058 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.6071
Onchocerca volvulus 0.002 0.0035 0.0426
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0013 0.001
Brugia malayi Cytochrome P450 family protein 0.0032 0.0066 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0009 0.0004 0.0612
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0009 0.0004 0.0612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0129 0.0126
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0188 0.0614
Brugia malayi hypothetical protein 0.0286 0.0749 0.0746
Leishmania major cathepsin L-like protease 0.0077 0.0188 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0009 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0009 0.0004 0.0612
Onchocerca volvulus 0.002 0.0035 0.0426
Trypanosoma brucei cytochrome P450, putative 0.0009 0.0004 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0078 0.0074
Loa Loa (eye worm) hypothetical protein 0.0286 0.0749 0.0747
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0009 0.0004 0.007
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0009 0.0004 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0035 0.0426
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0013 0.001
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1126 0.3012 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2617 0.2614
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0013 0.001
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0009 0.0004 0.007
Entamoeba histolytica cysteine proteinase 2 0.001 0.0009 0.0994
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0004 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0009 0.0004 0.0612
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0009 0.0004 0.0021
Brugia malayi steroid hormone receptor 0.0012 0.0013 0.001
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0009 0.0004 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0035 0.0426
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0014
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0009 0.0004 0.0612
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0009 0.0004 0.0612
Onchocerca volvulus 0.0058 0.0137 0.1795
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0009 0.0004 0.0001
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0188 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0009 0.0004 0.007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0078 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0013 0.001
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0035 0.0032
Loa Loa (eye worm) ctsf protein 0.002 0.0035 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0188 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0013 0.001
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0035 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0188 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0035 0.5841
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0009 0.0994
Brugia malayi nuclear hormone receptor 0.0012 0.0013 0.001
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0058 0.0054
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0188 1
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0009 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0013 0.001
Leishmania major cathepsin L-like protease 0.0077 0.0188 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0058 1
Echinococcus multilocularis cysteine protease 0.002 0.0035 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0058 0.0054
Onchocerca volvulus 0.0029 0.0058 0.0728
Loa Loa (eye worm) hypothetical protein 0.0182 0.0472 0.0469
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0013 0.001
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0013 0.001
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0013 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0013 0.001
Plasmodium vivax unspecified product 0.001 0.0009 0.0727
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.001
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0009 0.0004 0.0612
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0009 0.0004 0.007
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0058 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0013 0.001
Leishmania major cysteine peptidase A (CPA) 0.002 0.0035 0.1721
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0058 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0003 0.0546
Loa Loa (eye worm) hypothetical protein 0.0036 0.0078 0.0075
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0035 0.0032
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0009 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0078 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0188 0.0614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0009 0.0004 0.0612
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0129 0.0126
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0013 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0013 0.001
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0058 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0009 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0129 0.0126
Mycobacterium ulcerans hypothetical protein 0.0029 0.0058 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0013 0.0137
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0003 0.0546
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0009 0.0004 0.0612
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0035 0.0032
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0009 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0078 0.0074
Onchocerca volvulus 0.002 0.0035 0.0426
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0009 0.0004 0.0612
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0013 0.001
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0035 0.9097
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0013 0.001
Echinococcus multilocularis cysteine protease 0.002 0.0035 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0058 1
Onchocerca volvulus 0.0286 0.0751 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0188 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0009 0.0004 0.0021
Onchocerca volvulus 0.0036 0.0078 0.0996
Echinococcus multilocularis cathepsin L 0.001 0.0009 0.0005
Onchocerca volvulus 0.002 0.0035 0.0426
Plasmodium vivax vivapain-3 0.001 0.0009 0.0727
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0058 1
Leishmania major cytochrome p450-like protein 0.0009 0.0004 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0009 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0013 0.001
Echinococcus granulosus cathepsin l1 0.002 0.0035 0.0032
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0144 0.0466
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0058 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0035 0.5841
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0058 0.2947
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0035 0.0426
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0188 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0035 0.0426
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0009 0.0004 0.0612
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0009 0.0004 0.0612
Onchocerca volvulus 0.002 0.0035 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0013 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0013 0.001
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0009 0.0004 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0058 0.2947
Toxoplasma gondii cathepsin CPL 0.002 0.0035 0.4274
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0017 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0035 0.0426
Leishmania major cathepsin L-like protease 0.002 0.0035 0.1721
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0009 0.0004 0.0612
Schistosoma mansoni coup transcription factor 0.0012 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0013 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0009 0.0293
Onchocerca volvulus 0.0014 0.0017 0.0185
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0014
Brugia malayi Cathepsin L-like precursor 0.002 0.0035 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0009 0.0293
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0003 0.0546
Brugia malayi ecdysteroid receptor 0.0012 0.0013 0.001
Onchocerca volvulus 0.0012 0.0013 0.0137
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.001
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0009 0.0004 0.0612
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0009 0.0072
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0657 0.0655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Leishmania major cathepsin L-like protease 0.002 0.0035 0.1721
Leishmania major cathepsin L-like protease 0.002 0.0035 0.1721
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0013 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0188 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0003 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0013 0.001
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0013 0.001
Onchocerca volvulus Cathepsin L homolog 0.002 0.0035 0.0426
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0035 0.9097
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0009 0.0004 0.007
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0009 0.0004 0.007
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.1121 0.2997 0.3
Brugia malayi Cathepsin L-like precursor 0.0014 0.0017 0.0014
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0009 0.0004 0.007
Loa Loa (eye worm) fibroinase 0.002 0.0035 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0035 0.0426
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0009 0.0004 0.0612
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0188 0.0614
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0003 0.0546
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0035 0.0426
Entamoeba histolytica cysteine protease, putative 0.001 0.0009 0.0994
Brugia malayi Cathepsin L-like precursor 0.002 0.0035 0.0032
Brugia malayi Cathepsin L-like precursor 0.002 0.0035 0.0032
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0009 0.0004 0.007
Mycobacterium leprae Conserved hypothetical protein 0.0009 0.0004 0.007
Brugia malayi Cathepsin L-like precursor 0.002 0.0035 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.0035
Brugia malayi Pre-SET motif family protein 0.0036 0.0078 0.0074
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0035 0.0032
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0078 0.0074

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.258925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 5.011872336 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 0.2512 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 6.7456 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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