Detailed information for compound 1625777

Basic information

Technical information
  • TDR Targets ID: 1625777
  • Name: 1-methyl-4-(2-nitrophenyl)sulfanylbenzene
  • MW: 245.297 | Formula: C13H11NO2S
  • H donors: 0 H acceptors: 2 LogP: 4.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Sc1ccccc1[N+](=O)[O-]
  • InChi: 1S/C13H11NO2S/c1-10-6-8-11(9-7-10)17-13-5-3-2-4-12(13)14(15)16/h2-9H,1H3
  • InChiKey: UBBFBJSKBNASAJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-methylphenyl)sulfanylphenyl]-N-oxidohydroxylamine
  • N-hydroxy-2-(4-methylphenyl)sulfanylbenzeneamine oxide
  • 1-methyl-4-(2-nitrophenyl)sulfanyl-benzene
  • N-[2-(4-methylphenyl)sulfanylphenyl]-N-oxido-hydroxylamine
  • N-hydroxy-2-(4-methylphenyl)sulfanyl-benzeneamine oxide
  • 1-methyl-4-[(2-nitrophenyl)thio]benzene
  • N-[2-[(4-methylphenyl)thio]phenyl]-N-oxidohydroxylamine
  • N-hydroxy-2-[(4-methylphenyl)thio]benzeneamine oxide
  • N-[2-[(4-methylphenyl)thio]phenyl]-N-oxido-hydroxylamine
  • AIDS160311
  • Hydroxy(2-((4-methylphenyl)thio)phenyl)azane oxide
  • AIDS005718
  • 2-Nitrophenyl 4-methylphenyl sulfide
  • 2NO2Ph-S-4MePh
  • AIDS-005718
  • NSC624232
  • AIDS-160311
  • NCI60_007285

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0934 0.355 1
Brugia malayi cytochrome P450 0.0026 0.0025 0.0071
Trypanosoma brucei cytochrome P450, putative 0.0035 0.0062 0.016
Brugia malayi Receptor family ligand binding region containing protein 0.0058 0.015 0.0422
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.015 0.017
Trypanosoma brucei THT1 - hexose transporter, putative 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Giardia lamblia Hexose transporter 0.0934 0.355 1
Echinococcus multilocularis tumor protein p63 0.0266 0.0958 0.1277
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.0008 0.001
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0026 0.0025 0.0049
Loa Loa (eye worm) hypothetical protein 0.0038 0.0073 0.0206
Trypanosoma brucei glucose transporter, putative 0.0934 0.355 1
Echinococcus multilocularis sodium channel protein 0.0263 0.0947 0.1261
Schistosoma mansoni DNA polymerase eta 0.003 0.0041 0.0092
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0026 0.0025 0.0017
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Echinococcus granulosus geminin 0.013 0.0428 0.0505
Leishmania major glucose transporter, lmgt3 0.0934 0.355 1
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0057 0.0147 0.0351
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0312 0.1137 0.3158
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0026 0.0025 0.0049
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0025 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0041 0.0102
Plasmodium vivax hexose transporter 0.0934 0.355 1
Onchocerca volvulus 0.0039 0.0076 0.0192
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0058 0.015 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0934 0.355 1
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0041 0.0115
Echinococcus granulosus solute carrier family 22 0.0934 0.355 0.4262
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0086 0.2983
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0057 0.0147 0.0351
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0041 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0041 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0026 0.0025 0.0049
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.003 0.0041 0.0093
Loa Loa (eye worm) cytochrome P450 family protein 0.0146 0.0489 0.1379
Trichomonas vaginalis glucose transporter, putative 0.0934 0.355 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0026 0.0025 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0041 0.0102
Onchocerca volvulus 0.0057 0.0147 0.0393
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0113 0.0295
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0086 0.0129
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Brugia malayi Major Facilitator Superfamily protein 0.0934 0.355 1
Trypanosoma brucei glucose transporter, putative 0.0934 0.355 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0041 0.005
Brugia malayi Guanylyl cyclase protein 23 0.0058 0.015 0.0422
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Onchocerca volvulus 0.0934 0.355 1
Schistosoma mansoni tyrosine kinase 0.0058 0.015 0.0399
Schistosoma mansoni hypothetical protein 0.0037 0.0068 0.0167
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0026 0.0025 0.0049
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0086 0.022
Echinococcus granulosus synaptic vesicle 2 protein 0.0934 0.355 0.4262
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0026 0.0025 0.0049
Loa Loa (eye worm) major facilitator superfamily transporter 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Echinococcus multilocularis solute carrier family 22 0.0934 0.355 0.4761
Echinococcus granulosus dna polymerase eta 0.003 0.0041 0.0039
Echinococcus multilocularis receptor type guanylyl cyclase 0.0058 0.015 0.019
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0026 0.0025 0.0017
Schistosoma mansoni intermediate filament proteins 0.0036 0.0065 0.0161
Echinococcus multilocularis GPCR, family 3, C terminal 0.01 0.0313 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0073 0.0091
Trypanosoma brucei unspecified product 0.003 0.0041 0.0102
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0086 0.0105
Brugia malayi Cytochrome P450 family protein 0.0035 0.0062 0.0173
Brugia malayi Sugar transporter family protein 0.0934 0.355 1
Schistosoma mansoni hypothetical protein 0.0037 0.0068 0.0167
Brugia malayi Importin beta-1 subunit 0.0022 0.0008 0.0024
Brugia malayi Major Facilitator Superfamily protein 0.0934 0.355 1
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0057 0.0147 0.0401
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.0008 0.001
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0934 0.355 0.4262
Toxoplasma gondii facilitative glucose transporter GT1 0.0934 0.355 1
Brugia malayi Sugar transporter family protein 0.0934 0.355 1
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0934 0.355 0.3545
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0041 0.005
Echinococcus multilocularis nmda type glutamate receptor 0.0058 0.015 0.019
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0147 0.0351
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0934 0.355 1
Leishmania major hypothetical protein, conserved 0.0934 0.355 1
Echinococcus granulosus dna polymerase kappa 0.003 0.0041 0.0039
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0934 0.355 1
Mycobacterium ulcerans sugar transporter 0.0934 0.355 1
Schistosoma mansoni glucose transporter 0.0934 0.355 1
Trichomonas vaginalis sugar transport protein, putative 0.0934 0.355 1
Loa Loa (eye worm) choline O-acetyltransferase 0.0057 0.0147 0.0414
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0086 0.0129
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0312 0.1137 0.1517
Onchocerca volvulus 0.0934 0.355 1
Brugia malayi Choline O-acetyltransferase 0.0057 0.0147 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0934 0.355 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0934 0.355 0.4761
Leishmania major extracellular receptor, putative 0.0058 0.015 0.0401
Brugia malayi TAR-binding protein 0.0049 0.0113 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0934 0.355 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0086 0.0129
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0934 0.355 0.4761
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0934 0.355 0.4761
Trypanosoma cruzi glucose transporter, putative 0.0934 0.355 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.015 0.0422
Onchocerca volvulus 0.0934 0.355 1
Trichomonas vaginalis conserved hypothetical protein 0.0934 0.355 1
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0147 0.0351
Leishmania major carnitine/choline acetyltransferase, putative 0.0057 0.0147 0.0393
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Echinococcus granulosus GPCR family 3 C terminal 0.01 0.0313 0.0367
Onchocerca volvulus Poor gastrulation protein homolog 0.01 0.0313 0.0862
Trypanosoma brucei glucose transporter, putative 0.0934 0.355 1
Loa Loa (eye worm) hypothetical protein 0.0652 0.2455 0.6916
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0702 0.2648 0.7455
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0057 0.0147 0.0401
Trypanosoma brucei glucose transporter 2A 0.0934 0.355 1
Echinococcus granulosus sodium channel protein 0.0263 0.0947 0.1129
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0083 0.0245 0.0719
Brugia malayi Major Facilitator Superfamily protein 0.0934 0.355 1
Leishmania major carnitine palmitoyltransferase-like protein 0.0057 0.0147 0.0393
Toxoplasma gondii sugar transporter ST3 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Mycobacterium leprae Conserved hypothetical protein 0.0873 0.3312 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0086 0.0129
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0026 0.0025 0.0017
Trypanosoma cruzi sugar transporter, putative 0.0934 0.355 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0089 0.0271 1
Brugia malayi RNA binding protein 0.0049 0.0113 0.0318
Echinococcus granulosus solute carrier family 22 0.0934 0.355 0.4262
Onchocerca volvulus 0.0934 0.355 1
Schistosoma mansoni hypothetical protein 0.0037 0.0068 0.0167
Loa Loa (eye worm) sugar transporter 0.0934 0.355 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.01 0.0313 0.0883
Schistosoma mansoni sugar transporter 0.0934 0.355 1
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0263 0.0947 0.265
Schistosoma mansoni glutamate receptor NMDA 0.0058 0.015 0.0399
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0026 0.0025 0.0049
Brugia malayi hypothetical protein 0.0058 0.015 0.0422
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0652 0.2455 0.6916
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trypanosoma cruzi hexose transporter, putative 0.0934 0.355 1
Onchocerca volvulus 0.0934 0.355 1
Onchocerca volvulus 0.0934 0.355 1
Mycobacterium ulcerans integral membrane transport protein 0.0934 0.355 1
Echinococcus granulosus solute carrier family 22 0.0934 0.355 0.4262
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0026 0.0025 0.0017
Echinococcus multilocularis choline O acetyltransferase 0.0057 0.0147 0.0186
Leishmania major glucose transporter, lmgt1 0.0934 0.355 1
Echinococcus multilocularis protein patched 0.0038 0.0073 0.0087
Echinococcus multilocularis geminin 0.013 0.0428 0.0564
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0073 0.0206
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0026 0.0025 0.0049
Onchocerca volvulus 0.0058 0.015 0.0401
Schistosoma mansoni protein kinase 0.0058 0.015 0.0399
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Schistosoma mansoni sugar transporter 0.0934 0.355 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0086 0.0105
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0934 0.355 0.4761
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0026 0.0025 0.0049
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0062 0.0108
Brugia malayi Metabotropic glutamate receptor precursor. 0.0617 0.232 0.6536
Echinococcus multilocularis lamin 0.0036 0.0065 0.0077
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.2383 0.9172 0.9171
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0026 0.0025 0.0058
Trichomonas vaginalis glucose transporter, putative 0.0934 0.355 1
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0057 0.0147 0.0351
Loa Loa (eye worm) hypothetical protein 0.0058 0.015 0.0422
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0158 0.0539 0.1517
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0026 0.0025 0.0049
Schistosoma mansoni metabotropic glutamate receptor 0.0517 0.1931 0.5429
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.015 0.019
Echinococcus granulosus Niemann Pick C1 protein 0.0089 0.0271 0.0315
Echinococcus multilocularis snurportin 1 0.0231 0.0821 0.1092
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0026 0.0025 0.0017
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0086 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0113 0.0295
Echinococcus multilocularis glutamate receptor 2 0.0058 0.015 0.019
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0058 0.015 0.017
Schistosoma mansoni hypothetical protein 0.0037 0.0068 0.0167
Schistosoma mansoni patched 1 0.0038 0.0073 0.0182
Echinococcus multilocularis lamin dm0 0.0036 0.0065 0.0077
Treponema pallidum replicative DNA helicase (dnaB) 0.0296 0.1073 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0158 0.0539 0.1517
Echinococcus granulosus glutamate receptor 2 0.0058 0.015 0.017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0022
Trypanosoma brucei glucose transporter, putative 0.0934 0.355 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0063 0.0177
Brugia malayi Intermediate filament tail domain containing protein 0.0036 0.0065 0.0184
Brugia malayi CHE-14 protein 0.0038 0.0073 0.0206
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0026 0.0025 0.0049
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0231 0.0821 0.2311
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0026 0.0025 0.0049
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0041 0.0115
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0934 0.355 1
Brugia malayi Choline O-acetyltransferase 0.0057 0.0147 0.0414
Loa Loa (eye worm) sugar transporter 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Echinococcus multilocularis solute carrier family 22 0.0934 0.355 0.4761
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0041 0.0102
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0057 0.0147 0.0414
Echinococcus multilocularis metabotropic glutamate receptor 5 0.076 0.2874 0.3852
Brugia malayi Receptor family ligand binding region containing protein 0.0158 0.0539 0.1517
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0086 0.0178
Echinococcus multilocularis Niemann Pick C1 protein 0.0127 0.0419 0.0552
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0041 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Echinococcus multilocularis dna polymerase eta 0.003 0.0041 0.0044
Leishmania major cytochrome p450-like protein 0.0026 0.0025 0.0049
Plasmodium vivax sugar transporter, putative 0.0934 0.355 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0086 0.023
Echinococcus granulosus Solute carrier family 22 5 0.2163 0.8318 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0058 0.015 0.0401
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.015 0.019
Schistosoma mansoni tyrosine kinase 0.0058 0.015 0.0399
Onchocerca volvulus 0.0057 0.0147 0.0393
Echinococcus multilocularis tar DNA binding protein 0.0049 0.0113 0.014
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0086 0.0243
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Onchocerca volvulus 0.0934 0.355 1
Giardia lamblia Sugar-proton symporter 0.0934 0.355 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.003 0.0041 0.1259
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0022
Echinococcus multilocularis tyrosine kinase 0.0058 0.015 0.019
Schistosoma mansoni glucose transport protein 0.0934 0.355 1
Trichomonas vaginalis conserved hypothetical protein 0.0934 0.355 1
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.015 0.0422
Echinococcus granulosus cytochrome P450 2K1 0.0026 0.0025 0.002
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0041 0.0102
Trypanosoma brucei glucose transporter, putative 0.0934 0.355 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0041 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Loa Loa (eye worm) twinkle helicase 0.0085 0.0253 0.0712
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0058 0.015 0.019
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0026 0.0025 0.0049
Brugia malayi hypothetical protein 0.0934 0.355 1
Trypanosoma cruzi extracellular receptor, putative 0.0058 0.015 0.0359
Echinococcus multilocularis solute carrier family 22 0.0934 0.355 0.4761
Leishmania major DNA polymerase kappa, putative 0.003 0.0041 0.0093
Brugia malayi major facilitator superfamily protein 0.0934 0.355 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0058 0.015 0.0422
Loa Loa (eye worm) hypothetical protein 0.0042 0.0086 0.0243
Trypanosoma brucei glucose transporter, putative 0.0934 0.355 1
Schistosoma mansoni hypothetical protein 0.0231 0.0821 0.2293
Loa Loa (eye worm) hypothetical protein 0.0058 0.015 0.0422
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0026 0.0025 0.0017
Echinococcus multilocularis musashi 0.0036 0.0065 0.0077
Loa Loa (eye worm) RGC/RGC protein kinase 0.0058 0.015 0.0422
Trypanosoma brucei THT1 - hexose transporter, putative 0.0934 0.355 1
Schistosoma mansoni sugar transporter 0.0934 0.355 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0026 0.0025 0.0017
Schistosoma mansoni glucose transport protein 0.0934 0.355 1
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0057 0.0147 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0934 0.355 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.015 0.017
Trypanosoma cruzi hexose transporter, putative 0.0934 0.355 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0041 0.0102
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.003 0.0041 0.0092
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0024
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0086 0.0094
Echinococcus granulosus Protein patched homolog 1 0.0038 0.0073 0.0078
Brugia malayi Cytochrome P450 family protein 0.0146 0.0489 0.1379
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0057 0.0147 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0041 0.0102
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0086 0.022
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0113 0.0295
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0062 0.0173
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0057 0.0147 0.0414
Echinococcus granulosus Sugar transporter ERD6 protein 0.0934 0.355 0.4262
Loa Loa (eye worm) hypothetical protein 0.0047 0.0106 0.03
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0057 0.0147 0.0401
Loa Loa (eye worm) hypothetical protein 0.0036 0.0065 0.0184
Loa Loa (eye worm) hypothetical protein 0.076 0.2874 0.8095
Leishmania major glucose transporter, lmgt2 0.0934 0.355 1
Loa Loa (eye worm) TAR-binding protein 0.0049 0.0113 0.0318
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.015 0.019
Schistosoma mansoni Replicative DNA helicase 0.0296 0.1073 0.3007
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0026 0.0025 0.0017
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0022
Chlamydia trachomatis replicative DNA helicase 0.0296 0.1073 1
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Brugia malayi RNA, U transporter 1 0.0062 0.0163 0.046
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0057 0.0147 0.0401
Echinococcus multilocularis Niemann Pick C1 protein 0.0089 0.0271 0.0352
Schistosoma mansoni choline o-acyltransferase 0.0057 0.0147 0.0391
Echinococcus granulosus tumor protein p63 0.0266 0.0958 0.1143
Echinococcus multilocularis dna polymerase kappa 0.003 0.0041 0.0044
Brugia malayi RNA recognition motif domain containing protein 0.0049 0.0113 0.0318
Echinococcus granulosus tar DNA binding protein 0.0049 0.0113 0.0126
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0934 0.355 1
Leishmania major cytochrome p450-like protein 0.0035 0.0062 0.0151
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0058 0.015 0.0422
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0517 0.1931 0.2314
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0026 0.0025 0.0017
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0934 0.355 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0934 0.355 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.003 0.0041 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trypanosoma cruzi hexose transporter 0.0934 0.355 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0934 0.355 0.3545
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0041 0.0102
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.015 0.017
Schistosoma mansoni terminal deoxycytidyl transferase 0.003 0.0041 0.0092
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.003 0.0041 0.0039
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0049 0.0113 0.0318
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0312 0.1137 0.1358
Onchocerca volvulus 0.0934 0.355 1
Onchocerca volvulus 0.0934 0.355 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.003 0.0041 0.0033
Onchocerca volvulus 0.0036 0.0065 0.0162
Echinococcus granulosus lamin 0.0036 0.0065 0.0068
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0057 0.0147 0.0414
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0086 0.0221
Schistosoma mansoni lamin 0.0036 0.0065 0.0161
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.0147 0.0401
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0026 0.0025 0.0017
Toxoplasma gondii sugar transporter ST1 0.0934 0.355 1
Echinococcus granulosus expressed conserved protein 0.0084 0.025 0.029
Leishmania major cytochrome p450-like protein 0.0026 0.0025 0.0049
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0057 0.0147 0.0167
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0934 0.355 1
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.01 0.0313 0.0862
Entamoeba histolytica hypothetical protein 0.0058 0.015 0.5402
Echinococcus granulosus atrial natriuretic peptide receptor 0.0058 0.015 0.017
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.0062 0.0151
Echinococcus granulosus intermediate filament protein 0.0036 0.0065 0.0068
Onchocerca volvulus 0.0934 0.355 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0934 0.355 0.4262
Schistosoma mansoni hypothetical protein 0.013 0.0428 0.1186
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0026 0.0025 0.0017
Echinococcus multilocularis glutamate receptor 2 0.0058 0.015 0.019
Echinococcus granulosus lamin dm0 0.0036 0.0065 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Toxoplasma gondii sugar transporter ST2 0.0934 0.355 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0934 0.355 0.4761
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0113 0.0295
Mycobacterium ulcerans recombinase A 0.0083 0.0245 0.067
Leishmania major DNA polymerase eta, putative 0.003 0.0041 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0026 0.0025 0.0017
Loa Loa (eye worm) intermediate filament protein 0.0036 0.0065 0.0184
Onchocerca volvulus 0.0057 0.0147 0.0393
Brugia malayi Niemann-Pick C1 protein precursor 0.0089 0.0271 0.0762
Leishmania major myo-inositol/proton symporter (MIT) 0.0934 0.355 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0041 0.005
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0312 0.1137 0.3188
Mycobacterium leprae Conserved hypothetical protein 0.0026 0.0025 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.0544 0.2036 0.2726
Loa Loa (eye worm) hypothetical protein 0.0058 0.015 0.0422
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0041 0.0102
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0147 0.0351
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0214
Loa Loa (eye worm) cytochrome P450 0.0026 0.0025 0.0071
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0086 0.0105
Toxoplasma gondii cytochrome p450 superfamily protein 0.0026 0.0025 0.0047
Trichomonas vaginalis myo-inositol transporter, putative 0.0934 0.355 1
Plasmodium falciparum hexose transporter 0.0934 0.355 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.003 0.0041 0.0115
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0559 0.2095 0.5901
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0113 0.0295
Echinococcus multilocularis expressed conserved protein 0.0084 0.025 0.0324
Loa Loa (eye worm) hypothetical protein 0.01 0.0313 0.0883
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0263 0.0947 0.1129
Onchocerca volvulus 0.0934 0.355 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0271 0.0762
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0026 0.0025 0.0017
Trypanosoma brucei glucose transporter, putative 0.0934 0.355 1
Trypanosoma brucei sugar transporter, putative 0.0934 0.355 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0062 0.0173
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0026 0.0025 0.0017
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0026 0.0025 0.0049
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0026 0.0025 0.0017
Schistosoma mansoni hypothetical protein 0.01 0.0313 0.0861
Brugia malayi major facilitator superfamily protein 0.0934 0.355 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0022
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.003 0.0041 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0026 0.0025 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0026 0.0025 0.0049
Echinococcus multilocularis sterol regulatory element binding protein 0.0038 0.0073 0.0087
Echinococcus granulosus sterol regulatory element binding protein 0.0038 0.0073 0.0078
Onchocerca volvulus 0.0057 0.0147 0.0393
Echinococcus granulosus metabotropic glutamate receptor 5 0.076 0.2874 0.3448
Loa Loa (eye worm) glutamate receptor 0.0617 0.232 0.6536
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0036 0.0065 0.0184
Schistosoma mansoni lamin 0.0036 0.0065 0.0161
Brugia malayi hypothetical protein 0.0934 0.355 1
Onchocerca volvulus 0.0934 0.355 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0041 0.005
Echinococcus multilocularis 0.0026 0.0025 0.0023
Brugia malayi metabotropic glutamate receptor type 2 0.0301 0.1092 0.3077
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0296 0.1073 0.2506
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0091 0.0276 0.0755
Onchocerca volvulus 0.0058 0.015 0.0401
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0026 0.0025 0.0049
Onchocerca volvulus Putative transporter 0.0934 0.355 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0934 0.355 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.015 0.0422
Schistosoma mansoni hypothetical protein 0.0026 0.0025 0.0047
Loa Loa (eye worm) glutamate receptor 0.0243 0.0867 0.2442
Brugia malayi Cytochrome P450 family protein 0.0035 0.0062 0.0173
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Onchocerca volvulus 0.0036 0.0065 0.0162
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0517 0.1931 0.2585
Schistosoma mansoni sugar transporter 0.0934 0.355 1
Echinococcus granulosus snurportin 1 0.0231 0.0821 0.0977
Brugia malayi Sugar transporter family protein 0.0934 0.355 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0026 0.0025 0.0049
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0147 0.0414
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0041 0.0102
Loa Loa (eye worm) hypothetical protein 0.0058 0.015 0.0422
Schistosoma mansoni hypothetical protein 0.0934 0.355 1
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Loa Loa (eye worm) RNA binding protein 0.0049 0.0113 0.0318
Onchocerca volvulus 0.0934 0.355 1
Echinococcus granulosus glutamate receptor 2 0.0058 0.015 0.017
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0057 0.0147 0.0351
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0312 0.1137 0.3158
Echinococcus multilocularis protein dispatched 1 0.0044 0.0094 0.0115
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0026 0.0025 0.0049
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0025 0.0023 0.0052
Loa Loa (eye worm) RGC/RGC protein kinase 0.0058 0.015 0.0422
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1938 0.7446 1
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0296 0.1073 0.3008
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Echinococcus granulosus solute carrier family 22 0.0934 0.355 0.4262
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0058 0.015 0.0422
Trichomonas vaginalis glucose transporter, putative 0.0934 0.355 1
Echinococcus granulosus tyrosine kinase 0.0058 0.015 0.017
Schistosoma mansoni glucose transport protein 0.0934 0.355 1
Schistosoma mansoni hypothetical protein 0.013 0.0428 0.1186
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0057 0.0147 0.0186
Loa Loa (eye worm) hypothetical protein 0.0158 0.0539 0.1517
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0086 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0147 0.0351
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0062 0.0108
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0934 0.355 0.4761
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0041 0.005
Onchocerca volvulus 0.0934 0.355 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0025 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0026 0.0025 0.0017
Brugia malayi Cytochrome P450 family protein 0.0026 0.0025 0.0071
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0026 0.0025 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0026 0.0025 0.0017
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0062 0.0173
Mycobacterium leprae putative cytochrome p450 0.0026 0.0025 0.0053
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0057 0.0147 0.0414
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0026 0.0025 0.0017
Brugia malayi intermediate filament protein 0.0036 0.0065 0.0184
Onchocerca volvulus 0.0934 0.355 1
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0296 0.1073 0.3225
Trypanosoma brucei glucose transporter, putative 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0147 0.0351
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0041 0.0093
Trypanosoma cruzi hexose transporter, putative 0.0934 0.355 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0026 0.0025 0.0049
Schistosoma mansoni cytochrome P450 0.0026 0.0025 0.0047
Trypanosoma brucei THT1 - hexose transporter, putative 0.0934 0.355 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0058 0.015 0.017
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0086 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0934 0.355 1
Schistosoma mansoni choline o-acyltransferase 0.0057 0.0147 0.0391
Echinococcus multilocularis solute carrier family 22 0.0934 0.355 0.4761
Echinococcus granulosus Niemann Pick C1 protein 0.0127 0.0419 0.0494
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0041 0.0093
Schistosoma mansoni microtubule-associated protein tau 0.0544 0.2036 0.5725
Schistosoma mansoni metabotropic glutamate receptor 0.0301 0.1092 0.306
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0026 0.0025 0.0049
Echinococcus granulosus nmda type glutamate receptor 0.0058 0.015 0.017
Trypanosoma brucei glucose transporter 1E 0.0934 0.355 1
Trypanosoma cruzi hexose transporter, putative 0.0934 0.355 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0934 0.355 0.4262
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0026 0.0025 0.0049
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Trypanosoma brucei DNA polymerase eta, putative 0.003 0.0041 0.0102
Echinococcus granulosus choline O acetyltransferase 0.0057 0.0147 0.0167
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0026 0.0025 0.0049
Loa Loa (eye worm) hypothetical protein 0.0934 0.355 1
Onchocerca volvulus 0.0934 0.355 1
Trichomonas vaginalis sugar transporter, putative 0.0934 0.355 1
Schistosoma mansoni cellular tumor antigen P53 0.0039 0.0076 0.019
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0934 0.355 0.4262
Toxoplasma gondii transporter, major facilitator family protein 0.0934 0.355 1
Echinococcus granulosus microtubule associated protein 2 0.0544 0.2036 0.244

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.712 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.678 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.562 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.541 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.526 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.491 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.482 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.36 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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