Detailed information for compound 1643383

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 993.204 | Formula: C52H72N12O8
  • H donors: 9 H acceptors: 10 LogP: 2.99 Rotable bonds: 36
    Rule of 5 violations (Lipinski): 3
  • SMILES: NCCCC[C@@H](C(=O)C)NC(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)C)Cc1ccccc1)Cc1nc[nH]c1)CCCc1ccccc1)Cc1nc[nH]c1
  • InChi: 1S/C52H72N12O8/c1-5-33(2)46(52(72)62-44(28-39-30-55-32-57-39)49(69)58-40(34(3)65)21-12-13-24-53)63-47(67)41(22-14-20-36-16-8-6-9-17-36)59-50(70)43(27-38-29-54-31-56-38)60-48(68)42(26-37-18-10-7-11-19-37)61-51(71)45-23-15-25-64(45)35(4)66/h6-11,16-19,29-33,40-46H,5,12-15,20-28,53H2,1-4H3,(H,54,56)(H,55,57)(H,58,69)(H,59,70)(H,60,68)(H,61,71)(H,62,72)(H,63,67)/t33-,40-,41-,42-,43-,44-,45-,46-/m0/s1
  • InChiKey: POHGLEAKXVIJCA-VZMLCZHDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens renin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva cathepsin E, putative Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl protease ASP1 Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus granulosus cathepsin d lysosomal aspartyl protease Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin II Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum Cathepsin D precursor, putative Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Renin, related Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi aspartyl protease, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii plasmepsin Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin I Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium parvum membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) aspartic protease BmAsp-2 Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium hominis aspartyl protease precursor Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax aspartyl proteinase, putative Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Pepsinogen A1, related Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K01379 cathepsin D [EC3.4.23.5], putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva pepsinogen, putative Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Babesia bovis eukaryotic aspartyl protease family protein Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl proteinase (eimepsin), putative Get druggable targets OG5_126885 All targets in OG5_126885
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum plasmepsin X renin 406 aa 352 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis fat cadherin tumor suppressor 0.0186 0.0307 0.0855
Trichomonas vaginalis conserved hypothetical protein 0.092 0.2062 1
Loa Loa (eye worm) hypothetical protein 0.0456 0.0954 0.0951
Loa Loa (eye worm) hypothetical protein 0.0145 0.0208 0.0205
Brugia malayi cathepsin L precursor 0.0197 0.0334 0.0318
Schistosoma mansoni biogenic amine (dopamine) receptor 0.031 0.0605 0.0605
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.008 0.0053 0.0147
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0076 0.0043 0.0043
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0327 0.0645 0.1796
Echinococcus granulosus somatostatin receptor 0.031 0.0605 0.1685
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0076 0.0043 0.0043
Treponema pallidum sodium- and chloride- dependent transporter 0.0323 0.0636 0.5
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0327 0.0645 0.063
Brugia malayi hypothetical protein 0.0547 0.117 0.1156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Loa Loa (eye worm) hypothetical protein 0.0547 0.117 0.1167
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.008 0.0053 0.0147
Brugia malayi Papain family cysteine protease containing protein 0.0197 0.0334 0.0318
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0197 0.0334 0.1604
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0179 0.0291 0.0287
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.031 0.0605 0.059
Echinococcus granulosus RNA directed DNA polymerase 0.008 0.0053 0.0147
Echinococcus granulosus neurogenic locus notch protein 0.0186 0.0307 0.0855
Echinococcus multilocularis cysteine protease 0.0881 0.197 0.5487
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.117 0.117
Echinococcus multilocularis neurogenic locus notch protein 4 0.0186 0.0307 0.0855
Schistosoma mansoni sodium/chloride dependent transporter 0.0179 0.0291 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0265 0.0497 0.2396
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.016 0.0245 0.0682
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0103 0.0109 0.0305
Loa Loa (eye worm) hypothetical protein 0.0076 0.0043 0.004
Brugia malayi G-protein coupled receptor 0.031 0.0605 0.059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2129 0.2531
Loa Loa (eye worm) fibroinase 0.0881 0.197 0.1967
Brugia malayi angiogenesis inhibito 0.0145 0.021 0.0194
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.117 0.117
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0347 0.0692 0.0689
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0197 0.0334 0.1604
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0618 0.1341 0.1341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.031 0.0605 0.0605
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0059 0.0004 0.001
Plasmodium vivax vivapain-2 0.0881 0.197 0.9557
Echinococcus granulosus ankyrin repeat protein 0.0153 0.0228 0.0636
Brugia malayi Muscle positioning protein 4 0.0186 0.0307 0.0291
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0132 0.0178 0.0162
Onchocerca volvulus 0.031 0.0605 0.0593
Plasmodium vivax unspecified product 0.0277 0.0526 0.2539
Loa Loa (eye worm) hypothetical protein 0.0347 0.0692 0.0689
Echinococcus multilocularis Tolloid protein 1 0.0347 0.0692 0.1928
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0198 0.0335 0.0335
Schistosoma mansoni cathepsin F (C01 family) 0.0881 0.197 0.197
Loa Loa (eye worm) hypothetical protein 0.0604 0.1307 0.1304
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.092 0.2062 0.2059
Schistosoma mansoni neuropeptide receptor 0.031 0.0605 0.0605
Echinococcus granulosus tm gpcr rhodopsin 0.1549 0.3568 0.9936
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Loa Loa (eye worm) hypothetical protein 0.0604 0.1307 0.1304
Trypanosoma cruzi squalene synthase, putative 0.0264 0.0494 0.1248
Trypanosoma cruzi cysteine peptidase, putative 0.0948 0.2129 0.5867
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Loa Loa (eye worm) G-protein coupled receptor 0.031 0.0605 0.0602
Onchocerca volvulus 0.4239 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.031 0.0605 0.1685
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0197 0.0334 0.0318
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0197 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Brugia malayi hypothetical protein 0.031 0.0605 0.059
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.117 0.117
Plasmodium falciparum serine repeat antigen 5 0.0197 0.0334 0.1604
Onchocerca volvulus 0.0186 0.0307 0.0294
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.077 0.1705 0.4747
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0124 0.0158 0.0129
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0076 0.0043 0.0121
Schistosoma mansoni alpha-1 adrenergic receptor 0.031 0.0605 0.0605
Schistosoma mansoni pyruvate dehydrogenase 0.0727 0.1602 0.1602
Echinococcus granulosus zinc finger protein Ran binding 0.0327 0.0645 0.1796
Plasmodium vivax vivapain-3 0.0474 0.0997 0.4828
Echinococcus multilocularis zinc finger protein Ran binding 0.0327 0.0645 0.1796
Schistosoma mansoni hypothetical protein 0.092 0.2062 0.2062
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0076 0.0043 0.0028
Loa Loa (eye worm) hypothetical protein 0.0076 0.0043 0.004
Echinococcus multilocularis g protein coupled receptor 0.031 0.0605 0.1685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2129 0.2531
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0076 0.0043 0.0028
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0082 0.0059 0.0046
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Schistosoma mansoni hypothetical protein 0.0186 0.0307 0.0307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0881 0.197 0.9557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.0334 0.1604
Toxoplasma gondii ran binding protein 0.0327 0.0645 0.3116
Giardia lamblia Cathepsin L-like protease 0.0197 0.0334 0.2181
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.031 0.0605 0.0605
Schistosoma mansoni neuropeptide receptor 0.031 0.0605 0.0605
Echinococcus granulosus serotonin receptor 0.031 0.0605 0.1685
Brugia malayi Trypsin family protein 0.0547 0.117 0.1156
Echinococcus granulosus neuropeptide receptor 0.031 0.0605 0.1685
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0269 0.0507 0.0553
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0197 0.0334 0.1604
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.008 0.0053 0.0147
Loa Loa (eye worm) angiogenesis inhibito 0.0074 0.0039 0.0035
Echinococcus granulosus transient receptor potential cation channel 0.0168 0.0264 0.0735
Onchocerca volvulus 0.031 0.0605 0.0593
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0153 0.0228 0.0228
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Schistosoma mansoni histamine h1 receptor 0.031 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0347 0.0692 0.0678
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0269 0.0507 0.1283
Brugia malayi Fibulin-1 precursor 0.0347 0.0692 0.0678
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0076 0.0043 0.0139
Brugia malayi notch-like transmembrane receptor 0.0186 0.0307 0.0291
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0211 0.0368 0.0365
Toxoplasma gondii cathepsin CPC1 0.0307 0.0596 0.288
Loa Loa (eye worm) hypothetical protein 0.0072 0.0034 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.0334 0.1604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0197 0.0334 0.1604
Loa Loa (eye worm) hypothetical protein 0.0327 0.0645 0.0641
Loa Loa (eye worm) hypothetical protein 0.0277 0.0526 0.0523
Loa Loa (eye worm) hypothetical protein 0.4239 1 1
Loa Loa (eye worm) metalloprotease 0.0064 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Loa Loa (eye worm) solute carrier family 6 member 4 0.0323 0.0636 0.0633
Giardia lamblia Cathepsin L-like protease 0.0197 0.0334 0.2181
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus multilocularis fibrillin 1 0.0347 0.0692 0.1928
Loa Loa (eye worm) melatonin receptor type 1A 0.031 0.0605 0.0602
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.031 0.0605 0.1685
Echinococcus multilocularis sodium and chloride dependent glycine 0.0179 0.0291 0.081
Loa Loa (eye worm) hypothetical protein 0.0076 0.0043 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.0948 0.2129 0.5867
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0881 0.197 0.9557
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0881 0.197 0.9557
Schistosoma mansoni biogenic amine (5HT) receptor 0.031 0.0605 0.0605
Schistosoma mansoni cathepsin D (A01 family) 0.0174 0.0279 0.0279
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0186 0.0307 0.0307
Echinococcus granulosus g protein coupled receptor 0.031 0.0605 0.1685
Echinococcus multilocularis neuropeptide receptor 0.031 0.0605 0.1685
Brugia malayi cathepsin F-like cysteine proteinase 0.0197 0.0334 0.0318
Schistosoma mansoni hypothetical protein 0.092 0.2062 0.2062
Giardia lamblia Cathepsin B precursor 0.0618 0.1341 1
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0197 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0327 0.0645 0.0641
Schistosoma mansoni notch 0.0186 0.0307 0.0307
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.031 0.0605 0.1685
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.031 0.0605 0.0605
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0043 0.0194
Giardia lamblia Cysteine protease 0.0197 0.0334 0.2181
Echinococcus granulosus KRAB A domain containing protein 0.008 0.0053 0.0147
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Trypanosoma cruzi cruzipain precursor, putative 0.0948 0.2129 0.5867
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0197 0.0334 0.1604
Leishmania major cathepsin L-like protease 0.0881 0.197 0.9235
Loa Loa (eye worm) hypothetical protein 0.0082 0.0059 0.0056
Brugia malayi fibroinase precursor 0.0197 0.0334 0.0318
Trichomonas vaginalis reverse transcriptases, putative 0.008 0.0053 0.0238
Brugia malayi Serotonin receptor 0.031 0.0605 0.059
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0881 0.197 0.1967
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0474 0.0997 0.1151
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.031 0.0605 0.1685
Brugia malayi Cathepsin L-like precursor 0.0881 0.197 0.1958
Echinococcus multilocularis tissue type plasminogen activator 0.053 0.113 0.3147
Echinococcus granulosus Zinc finger RanBP2 type 0.0327 0.0645 0.1796
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0064 0.0016 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0132 0.0178 0.0178
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.016 0.0245 0.0241
Brugia malayi hypothetical protein 0.031 0.0605 0.059
Schistosoma mansoni growth hormone secretagogue receptor 0.031 0.0605 0.0605
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.031 0.0605 0.0602
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.117 0.117
Schistosoma mansoni pyruvate dehydrogenase 0.077 0.1705 0.1705
Schistosoma mansoni rhodopsin-like orphan GPCR 0.031 0.0605 0.0605
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0197 0.0334 0.033
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0618 0.1341 0.6194
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Entamoeba histolytica cysteine proteinase 1, putative 0.0474 0.0997 0.4915
Plasmodium vivax amine transporter, putative 0.0076 0.0043 0.0194
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.031 0.0605 0.1685
Giardia lamblia Cysteine protease 0.0197 0.0334 0.2181
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0881 0.197 0.5487
Schistosoma mansoni hypothetical protein 0.0145 0.0208 0.0208
Schistosoma mansoni notch 0.0186 0.0307 0.0307
Schistosoma mansoni neuropeptide receptor 0.031 0.0605 0.0605
Brugia malayi Calcium binding EGF domain containing protein 0.0186 0.0307 0.0291
Onchocerca volvulus 0.031 0.0605 0.0593
Onchocerca volvulus 0.031 0.0605 0.0593
Echinococcus multilocularis g protein coupled receptor 0.031 0.0605 0.1685
Schistosoma mansoni opsin-like receptor 0.031 0.0605 0.0605
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Echinococcus granulosus orexin receptor type 2 0.031 0.0605 0.1685
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0474 0.0997 0.0997
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.031 0.0605 0.0605
Loa Loa (eye worm) norepinephrine transporter 0.0323 0.0636 0.0633
Echinococcus multilocularis cysteine protease 0.0881 0.197 0.5487
Echinococcus granulosus cathepsin b 0.1559 0.3591 1
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.0334 0.1604
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus granulosus slit 2 protein 0.0193 0.0325 0.0906
Schistosoma mansoni hypothetical protein 0.0067 0.0023 0.0023
Leishmania major cathepsin L-like protease 0.0881 0.197 0.9235
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0197 0.0334 0.1448
Echinococcus multilocularis protein jagged 2 0.0186 0.0307 0.0855
Toxoplasma gondii beta-hydroxyacyl-acyl carrier protein dehydratase (FABZ) 0.0064 0.0015 0.0055
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0197 0.0334 0.1604
Schistosoma mansoni peptide (allatostatin)-like receptor 0.031 0.0605 0.0605
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.031 0.0605 0.059
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0198 0.0335 0.0933
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0197 0.0334 0.1604
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0076 0.0043 0.0043
Onchocerca volvulus 0.0547 0.117 0.1158
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0547 0.117 0.3259
Echinococcus granulosus cathepsin l cysteine peptidase 0.0881 0.197 0.5487
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1559 0.3591 0.3591
Brugia malayi EGF-like domain containing protein 0.0186 0.0307 0.0291
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.092 0.2062 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0145 0.0209 0.0999
Schistosoma mansoni biogenic amine (dopamine) receptor 0.031 0.0605 0.0605
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0327 0.0645 0.0722
Echinococcus multilocularis somatostatin receptor 0.031 0.0605 0.1685
Echinococcus granulosus SWI:SNF matrix associated 0.092 0.2062 0.5741
Brugia malayi Zinc knuckle family protein 0.008 0.0053 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0547 0.117 0.3259
Trypanosoma brucei squalene synthase, putative 0.0264 0.0494 0.0538
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Entamoeba histolytica cysteine protease, putative 0.0197 0.0334 0.1448
Leishmania major cathepsin L-like protease 0.0881 0.197 0.9235
Onchocerca volvulus 0.0547 0.117 0.1158
Loa Loa (eye worm) hypothetical protein 0.0197 0.0334 0.033
Loa Loa (eye worm) hypothetical protein 0.1559 0.3591 0.3588
Schistosoma mansoni lipoxygenase 0.0083 0.006 0.006
Onchocerca volvulus 0.0881 0.197 0.196
Giardia lamblia Cathepsin L precursor 0.0197 0.0334 0.2181
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0323 0.0636 0.0621
Onchocerca volvulus 0.053 0.113 0.1118
Brugia malayi cathepsin B-like cysteine proteinase 0.1559 0.3591 0.3581
Echinococcus granulosus neuropeptide Y receptor 0.031 0.0605 0.1685
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Echinococcus multilocularis fibropellin Ia 0.0186 0.0307 0.0855
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0881 0.197 0.9557
Echinococcus granulosus Tolloid protein 1 0.0347 0.0692 0.1928
Giardia lamblia Cathepsin B precursor 0.0197 0.0334 0.2181
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.077 0.1705 0.4747
Chlamydia trachomatis DNA topoisomerase I 0.092 0.2062 1
Onchocerca volvulus 0.031 0.0605 0.0593
Giardia lamblia Cysteine protease 0.0197 0.0334 0.2181
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0076 0.0043 0.0121
Schistosoma mansoni cathepsin C 0.0197 0.0334 0.0334
Wolbachia endosymbiont of Brugia malayi (3R)-hydroxymyristoyl-ACP dehydratase 0.0064 0.0015 0.5
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Loa Loa (eye worm) hypothetical protein 0.0076 0.0043 0.004
Plasmodium vivax serine-repeat antigen (SERA) 0.0197 0.0334 0.1604
Giardia lamblia Cathepsin B precursor 0.0197 0.0334 0.2181
Brugia malayi cathepsin Z-like cysteine proteinase 0.0197 0.0334 0.0318
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0474 0.0997 0.0997
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.031 0.0605 0.1685
Leishmania major hypothetical protein, conserved 0.0327 0.0645 0.2829
Brugia malayi Trypsin family protein 0.0547 0.117 0.1156
Brugia malayi Cadherin domain containing protein 0.0186 0.0307 0.0291
Echinococcus multilocularis glycoprotein Antigen 5 0.0648 0.1413 0.3936
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0081 0.0057 0.0158
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0347 0.0692 0.0689
Toxoplasma gondii cathepsin CPC2 0.0239 0.0433 0.2088
Echinococcus multilocularis orexin receptor type 2 0.031 0.0605 0.1685
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0347 0.0692 0.0692
Echinococcus granulosus tm gpcr rhodopsin 0.031 0.0605 0.1685
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.008 0.0053 0.0147
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0023 0.0063
Schistosoma mansoni amine GPCR 0.031 0.0605 0.0605
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0307 0.0596 0.4219
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0081 0.0057 0.0158
Brugia malayi RE15519p 0.031 0.0605 0.059
Echinococcus multilocularis biogenic amine (5HT) receptor 0.031 0.0605 0.1685
Schistosoma mansoni RNA binding protein 0.0327 0.0645 0.0645
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Onchocerca volvulus 0.0515 0.1095 0.1084
Onchocerca volvulus Cathepsin L homolog 0.0197 0.0334 0.0321
Echinococcus multilocularis g protein coupled receptor 0.031 0.0605 0.1685
Echinococcus multilocularis ring and YY1 binding protein 0.0327 0.0645 0.1796
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.031 0.0605 0.1685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.0334 0.1604
Schistosoma mansoni zinc finger protein 0.0327 0.0645 0.0645
Echinococcus granulosus potassium voltage gated channel subfamily H 0.016 0.0245 0.0682
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.031 0.0605 0.0605
Brugia malayi Tachykinin-like peptides receptor 99D 0.0456 0.0954 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0197 0.0334 0.1604
Echinococcus granulosus neuropeptides capa receptor 0.031 0.0605 0.1685
Entamoeba histolytica cysteine proteinase, putative 0.0474 0.0997 0.4915
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.008 0.0053 0.0147
Schistosoma mansoni laminin gamma-3 chain 0.0186 0.0307 0.0307
Leishmania major squalene synthase, putative 0.0264 0.0494 0.2101
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0023 0.0007
Loa Loa (eye worm) hypothetical protein 0.0064 0.0016 0.0012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.031 0.0605 0.1685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Brugia malayi SWIB/MDM2 domain containing protein 0.092 0.2062 0.2049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2129 0.2531
Schistosoma mansoni hypothetical protein 0.031 0.0605 0.0605
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0064 0.0016 0.0044
Onchocerca volvulus 0.031 0.0605 0.0593
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Entamoeba histolytica cysteine proteinase, putative 0.0474 0.0997 0.4915
Schistosoma mansoni hypothetical protein 0.0327 0.0645 0.0645
Onchocerca volvulus 0.0197 0.0334 0.0321
Onchocerca volvulus 0.092 0.2062 0.2051
Plasmodium falciparum serine repeat antigen 9 0.0197 0.0334 0.1604
Echinococcus multilocularis fmrfamide receptor 0.031 0.0605 0.1685
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0076 0.0043 0.0121
Loa Loa (eye worm) hypothetical protein 0.0327 0.0645 0.0641
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus multilocularis rhodopsin orphan GPCR 0.031 0.0605 0.1685
Loa Loa (eye worm) hypothetical protein 0.0323 0.0636 0.0633
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Onchocerca volvulus Cathepsin F homolog 0.0881 0.197 0.196
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0312 0.0609 0.2942
Entamoeba histolytica cysteine protease, putative 0.0197 0.0334 0.1448
Loa Loa (eye worm) hypothetical protein 0.0547 0.117 0.1167
Brugia malayi hypothetical protein 0.0081 0.0057 0.0041
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0327 0.0645 0.3116
Echinococcus multilocularis conserved hypothetical protein 0.1033 0.2332 0.6493
Onchocerca volvulus 0.031 0.0605 0.0593
Giardia lamblia Cathepsin L precursor 0.0197 0.0334 0.2181
Loa Loa (eye worm) notch protein 0.0186 0.0307 0.0303
Entamoeba histolytica cysteine proteinase 2 0.0474 0.0997 0.4915
Brugia malayi hypothetical protein 0.0136 0.0187 0.0171
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1559 0.3591 0.3591
Onchocerca volvulus 0.0547 0.117 0.1158
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0197 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0347 0.0692 0.0689
Schistosoma mansoni rhodopsin-like orphan GPCR 0.031 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus granulosus sodium and chloride dependent glycine 0.0179 0.0291 0.081
Loa Loa (eye worm) hypothetical protein 0.0604 0.1307 0.1304
Giardia lamblia Cathepsin L precursor 0.0197 0.0334 0.2181
Echinococcus multilocularis laminin 0.0347 0.0692 0.1928
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0618 0.1341 0.6499
Chlamydia trachomatis UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 0.0491 0.1036 0.499
Loa Loa (eye worm) matrixin family protein 0.0063 0.0013 0.001
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.117 0.117
Echinococcus multilocularis slit 2 protein 0.0193 0.0325 0.0906
Entamoeba histolytica cysteine protease, putative 0.0197 0.0334 0.1448
Brugia malayi hypothetical protein 0.031 0.0605 0.059
Plasmodium falciparum serine repeat antigen 8 0.0197 0.0334 0.1604
Plasmodium falciparum serine repeat antigen 6 0.0197 0.0334 0.1604
Echinococcus granulosus neuropeptides capa receptor 0.031 0.0605 0.1685
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.092 0.2062 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.0334 0.033
Toxoplasma gondii hypothetical protein 0.0076 0.0043 0.0194
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Brugia malayi ADAM-TS Spacer 1 family protein 0.0473 0.0994 0.098
Brugia malayi Serotonin/octopamine receptor family protein 7 0.031 0.0605 0.059
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.008 0.0053 0.0147
Trypanosoma cruzi cysteine proteinase, putative 0.0474 0.0997 0.2669
Brugia malayi EGF-like domain containing protein 0.0186 0.0307 0.0291
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus granulosus GPCR family 2 0.0067 0.0023 0.0063
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0277 0.0526 0.0511
Echinococcus multilocularis neurogenic locus protein delta 0.0186 0.0307 0.0855
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0197 0.0334 0.1604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0881 0.197 0.9557
Brugia malayi reverse transcriptase 0.008 0.0053 0.0037
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Trypanosoma cruzi hypothetical protein, conserved 0.0327 0.0645 0.1674
Trypanosoma cruzi hypothetical protein, conserved 0.0327 0.0645 0.1674
Schistosoma mansoni neuropeptide F-like receptor 0.031 0.0605 0.0605
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0307 0.0596 0.0596
Brugia malayi putative neuropeptide receptor NPR1 0.031 0.0605 0.059
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0327 0.0645 0.3116
Loa Loa (eye worm) hypothetical protein 0.0149 0.022 0.0216
Giardia lamblia Cysteine protease 0.0197 0.0334 0.2181
Schistosoma mansoni hypothetical protein 0.0067 0.0023 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2129 0.2531
Brugia malayi EGF-like domain containing protein 0.0186 0.0307 0.0291
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.031 0.0605 0.0593
Echinococcus multilocularis neuropeptides capa receptor 0.031 0.0605 0.1685
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.008 0.0053 0.0238
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.008 0.0053 0.0147
Loa Loa (eye worm) hypothetical protein 0.0211 0.0368 0.0365
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0064 0.0016 0.0016
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0327 0.0645 0.0632
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0136 0.0187 0.0187
Echinococcus multilocularis sex peptide receptor 0.031 0.0605 0.1685
Echinococcus multilocularis GPCR, family 2 0.0067 0.0023 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.031 0.0605 0.0605
Echinococcus granulosus G protein coupled receptor 139 0.031 0.0605 0.1685
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.0208 0.0193
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Echinococcus multilocularis alpha 1A adrenergic receptor 0.031 0.0605 0.1685
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.043 1
Echinococcus multilocularis transmembrane protease serine 3 0.0547 0.117 0.3259
Toxoplasma gondii EGF family domain-containing protein 0.0186 0.0307 0.1473
Trypanosoma cruzi cysteine peptidase, putative 0.0948 0.2129 0.5867
Brugia malayi Trypsin family protein 0.0547 0.117 0.1156
Onchocerca volvulus 0.031 0.0605 0.0593
Giardia lamblia Hypothetical protein 0.0197 0.0334 0.2181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Loa Loa (eye worm) hypothetical protein 0.0881 0.197 0.1967
Schistosoma mansoni slit 0.0186 0.0307 0.0307
Schistosoma mansoni biogenic amine (dopamine) receptor 0.031 0.0605 0.0605
Echinococcus granulosus neuropeptide Y receptor 0.031 0.0605 0.1685
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0071 0.0032 0.0032
Brugia malayi hypothetical protein 0.008 0.0053 0.0037
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Loa Loa (eye worm) hypothetical protein 0.0547 0.117 0.1167
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0327 0.0645 0.1674
Echinococcus granulosus g protein coupled receptor 0.031 0.0605 0.1685
Plasmodium vivax beta-hydroxyacyl-ACP dehydratase precursor, putative 0.0064 0.0015 0.0055
Schistosoma mansoni lipoxygenase 0.0118 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Echinococcus granulosus protein jagged 2 0.0186 0.0307 0.0855
Plasmodium falciparum serine repeat antigen 2 0.0197 0.0334 0.1604
Echinococcus multilocularis cathepsin b 0.1559 0.3591 1
Echinococcus multilocularis neuropeptides capa receptor 0.031 0.0605 0.1685
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0881 0.197 0.5487
Giardia lamblia Encystation-specific protease 0.0239 0.0433 0.2954
Echinococcus granulosus protein jagged 1 0.0186 0.0307 0.0855
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.008 0.0053 0.0147
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.077 0.1705 0.4747
Schistosoma mansoni sodium/chloride dependent transporter 0.0179 0.0291 0.0291
Echinococcus granulosus fmrfamide receptor 0.031 0.0605 0.1685
Trypanosoma cruzi major cysteine proteinase, putative 0.0263 0.0492 0.1242
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0064 0.0016 0.0016
Echinococcus multilocularis notch 0.0186 0.0307 0.0855
Trypanosoma cruzi hypothetical protein, conserved 0.0327 0.0645 0.1674
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.4239 1 1
Echinococcus multilocularis cathepsin L 0.0474 0.0997 0.2777
Echinococcus granulosus rhodopsin orphan GPCR 0.031 0.0605 0.1685
Echinococcus multilocularis tachykinin peptides receptor 99D 0.031 0.0605 0.1685
Schistosoma mansoni sodium-dependent amino acid transporter 0.0076 0.0043 0.0043
Loa Loa (eye worm) cathepsin B 0.0618 0.1341 0.1338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.031 0.0605 0.0605
Brugia malayi Calcitonin receptor-like protein seb-1 0.0211 0.0368 0.0353
Loa Loa (eye worm) TK/ROR protein kinase 0.053 0.113 0.1127
Loa Loa (eye worm) TYRA-2 protein 0.031 0.0605 0.0602
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0197 0.0334 0.1604
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0064 0.0016 0.0016
Onchocerca volvulus 0.0076 0.0043 0.003
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0082 0.0059 0.0178
Brugia malayi YY1-associated factor 2 0.0327 0.0645 0.063
Echinococcus multilocularis fmrfamide receptor 0.031 0.0605 0.1685
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Echinococcus granulosus rhodopsin orphan GPCR 0.031 0.0605 0.1685
Trypanosoma cruzi cysteine proteinase, putative 0.0474 0.0997 0.2669
Plasmodium falciparum serine repeat antigen 1 0.0197 0.0334 0.1604
Plasmodium vivax serine-repeat antigen (SERA) 0.0197 0.0334 0.1604
Echinococcus granulosus transmembrane protease serine 3 0.0547 0.117 0.3259
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.031 0.0605 0.0605
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Brugia malayi hypothetical protein 0.008 0.0053 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0881 0.197 0.9557
Trypanosoma cruzi phytoene synthase, putative 0.0082 0.0059 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0132 0.0178 0.0178
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1549 0.3568 0.9936
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.0334 0.1604
Brugia malayi Cathepsin L-like precursor 0.0604 0.1307 0.1293
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.031 0.0605 0.059
Onchocerca volvulus 0.031 0.0605 0.0593
Onchocerca volvulus Arrow homolog 0.0347 0.0692 0.068
Brugia malayi Cathepsin L-like precursor 0.0277 0.0526 0.0511
Onchocerca volvulus 0.3693 0.8693 0.8691
Leishmania major hypothetical protein, conserved 0.0327 0.0645 0.2829
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0197 0.0334 0.2181
Loa Loa (eye worm) hypothetical protein 0.077 0.1705 0.1702
Echinococcus granulosus serotonin transporter 0.0323 0.0636 0.1771
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.031 0.0605 0.0605
Plasmodium vivax hypothetical protein, conserved 0.092 0.2062 1
Onchocerca volvulus 0.0186 0.0307 0.0294
Echinococcus granulosus metabotropic glutamate receptor 5 0.0081 0.0057 0.0158
Brugia malayi cathepsin L-like cysteine proteinase 0.0197 0.0334 0.0318
Schistosoma mansoni cathepsin S (C01 family) 0.0197 0.0334 0.0334
Schistosoma mansoni biogenic amine (5HT) receptor 0.0493 0.1041 0.1041
Brugia malayi neuropeptide F receptor 0.031 0.0605 0.059
Onchocerca volvulus 0.031 0.0605 0.0593
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.008 0.0053 0.0238
Toxoplasma gondii hypothetical protein 0.0076 0.0043 0.0194
Schistosoma mansoni notch 0.0186 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.053 0.113 0.113
Trypanosoma cruzi cysteine protease, putative 0.0474 0.0997 0.2669
Onchocerca volvulus 0.0327 0.0645 0.0632
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0547 0.117 0.1156
Leishmania major hypothetical protein, conserved 0.0327 0.0645 0.2829
Giardia lamblia Cathepsin B precursor 0.0618 0.1341 1
Echinococcus granulosus cathepsin l1 0.0604 0.1307 0.3639
Plasmodium vivax unspecified product 0.0197 0.0334 0.1604
Onchocerca volvulus 0.031 0.0605 0.0593
Toxoplasma gondii calcium binding egf domain-containing protein 0.0347 0.0692 0.3347
Leishmania major hypothetical protein, conserved 0.0327 0.0645 0.2829
Loa Loa (eye worm) hypothetical protein 0.0136 0.0187 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0197 0.0334 0.1604
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Loa Loa (eye worm) hypothetical protein 0.0139 0.0196 0.0192
Giardia lamblia Cathepsin B precursor 0.0197 0.0334 0.2181
Echinococcus multilocularis neuropeptide s receptor 0.031 0.0605 0.1685
Schistosoma mansoni hypothetical protein 0.351 0.8256 0.8256
Leishmania major hypothetical protein, conserved 0.053 0.113 0.5174
Brugia malayi EGF-like domain containing protein 0.0186 0.0307 0.0291
Onchocerca volvulus 0.0881 0.197 0.196
Trypanosoma brucei developmentally regulated phosphoprotein 0.077 0.1705 0.2014
Loa Loa (eye worm) hypothetical protein 0.0323 0.0636 0.0633
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.092 0.2062 0.5741
Echinococcus granulosus neurogenic locus protein delta 0.0186 0.0307 0.0855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Echinococcus granulosus neuropeptide FF receptor 2 0.0456 0.0954 0.2657
Trypanosoma cruzi cysteine peptidase, putative 0.0277 0.0526 0.1338
Onchocerca volvulus 0.031 0.0605 0.0593
Schistosoma mansoni biogenic amine receptor 0.031 0.0605 0.0605
Echinococcus granulosus neurogenic locus notch protein 0.0186 0.0307 0.0855
Brugia malayi gonadotropin-releasing hormone receptor 2 0.031 0.0605 0.059
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0307 0.0596 0.288
Brugia malayi GCC2 and GCC3 family protein 0.0186 0.0307 0.0291
Echinococcus multilocularis neurogenic locus notch protein 0.0186 0.0307 0.0855
Leishmania major cathepsin L-like protease 0.0881 0.197 0.9235
Giardia lamblia Cathepsin L precursor 0.0197 0.0334 0.2181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2129 0.2531
Brugia malayi Calcium binding EGF domain containing protein 0.0186 0.0307 0.0291
Echinococcus granulosus cathepsin l1 0.0881 0.197 0.5487
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0023 0.0019
Onchocerca volvulus 0.031 0.0605 0.0593
Echinococcus granulosus 7TM GPCR rhodopsin 0.031 0.0605 0.1685
Schistosoma mansoni glutamate receptor NMDA 0.0082 0.0059 0.0059
Schistosoma mansoni amine GPCR 0.031 0.0605 0.0605
Echinococcus multilocularis serotonin receptor 0.0493 0.1041 0.2898
Schistosoma mansoni brg-1 associated factor 0.092 0.2062 0.2062
Echinococcus granulosus fibropellin Ia 0.0186 0.0307 0.0855
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0307 0.0596 0.288
Onchocerca volvulus 0.031 0.0605 0.0593
Giardia lamblia Cathepsin B precursor 0.0197 0.0334 0.2181
Schistosoma mansoni hypothetical protein 0.008 0.0053 0.0053
Echinococcus multilocularis Mastin 0.0648 0.1413 0.3936
Echinococcus granulosus neurogenic locus notch protein 4 0.0186 0.0307 0.0855
Trypanosoma brucei ingi protein (ORF1) 0.0124 0.0158 0.0129
Loa Loa (eye worm) Notch2 0.0186 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.0193 0.0325 0.0322
Plasmodium falciparum cysteine repeat modular protein 1 0.053 0.113 0.5474
Plasmodium falciparum amino acid transporter, putative 0.0076 0.0043 0.0194
Brugia malayi hypothetical protein 0.031 0.0605 0.059
Onchocerca volvulus Papilin homolog 0.0149 0.022 0.0207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2129 0.2531
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0197 0.0334 0.0334
Schistosoma mansoni adenoreceptor 0.031 0.0605 0.0605
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0076 0.0043 0.0028
Schistosoma mansoni hypothetical protein 0.031 0.0605 0.0605
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Leishmania major cathepsin L-like protease 0.0948 0.2129 1
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus granulosus enteropeptidase 0.0648 0.1413 0.3936
Onchocerca volvulus Slit protein homolog 0.0193 0.0325 0.0312
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0474 0.0997 0.2669
Brugia malayi EGF-like domain containing protein 0.0193 0.0325 0.031
Schistosoma mansoni amine GPCR 0.031 0.0605 0.0605
Echinococcus granulosus dro:myosuppressin receptor 0.031 0.0605 0.1685
Schistosoma mansoni rhodopsin-like orphan GPCR 0.031 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.0347 0.0692 0.0689
Loa Loa (eye worm) hypothetical protein 0.0347 0.0692 0.0689
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Onchocerca volvulus Cathepsin L homolog 0.0881 0.197 0.196
Trypanosoma cruzi cysteine peptidase, putative 0.0474 0.0997 0.2669
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.008 0.0053 0.0147
Schistosoma mansoni neuropeptide F-like receptor 0.031 0.0605 0.0605
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2129 0.2531
Loa Loa (eye worm) hypothetical protein 0.0081 0.0057 0.0053
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0881 0.197 0.1967
Loa Loa (eye worm) hypothetical protein 0.0547 0.117 0.1167
Echinococcus granulosus cathepsin b 0.1559 0.3591 1
Echinococcus multilocularis cathepsin L 0.0197 0.0334 0.0929
Brugia malayi Dopamine receptor protein 2 0.031 0.0605 0.059
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.117 0.117
Echinococcus granulosus adam 0.0136 0.0187 0.052
Giardia lamblia Hypothetical protein 0.0197 0.0334 0.2181
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Plasmodium vivax vivapain-2 0.0881 0.197 0.9557
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.031 0.0605 0.1685
Loa Loa (eye worm) serotonin transporter b 0.0323 0.0636 0.0633
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0239 0.0433 0.2088
Entamoeba histolytica cysteine protease, putative 0.0197 0.0334 0.1448
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0132 0.0178 0.0174
Brugia malayi Cadherin domain containing protein 0.0186 0.0307 0.0291
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Plasmodium falciparum serine repeat antigen 7 0.0197 0.0334 0.1604
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.0004 0.0004
Brugia malayi hypothetical protein 0.031 0.0605 0.059
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0379 0.077 0.0766
Brugia malayi hypothetical protein 0.031 0.0605 0.059
Schistosoma mansoni cathepsin B (C01 family) 0.0197 0.0334 0.0334
Brugia malayi sulfakinin receptor protein 0.031 0.0605 0.059
Onchocerca volvulus 0.0327 0.0645 0.0632
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.0334 0.1604
Brugia malayi Cathepsin L-like precursor 0.0881 0.197 0.1958
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1559 0.3591 0.3591
Schistosoma mansoni cathepsin F (C01 family) 0.0604 0.1307 0.1307
Onchocerca volvulus 0.0076 0.0043 0.003
Onchocerca volvulus 0.0323 0.0636 0.0624
Loa Loa (eye worm) glutamate receptor 0.0067 0.0022 0.0019
Schistosoma mansoni scy1(yeast) protein kinase-like 0.008 0.0053 0.0053
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0076 0.0043 0.0043
Brugia malayi Calcium binding EGF domain containing protein 0.0186 0.0307 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0197 0.0334 0.1604
Brugia malayi hypothetical protein 0.0076 0.0043 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.031 0.0605 0.1685
Echinococcus granulosus protein jagged 2 0.0186 0.0307 0.0855
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0145 0.0405
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.117 0.117
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Loa Loa (eye worm) hypothetical protein 0.0076 0.0043 0.004
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.117 0.117
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.092 0.2062 1
Onchocerca volvulus 0.0881 0.197 0.196
Trypanosoma brucei hypothetical protein, conserved 0.0327 0.0645 0.0722
Loa Loa (eye worm) hypothetical protein 0.0323 0.0636 0.0633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Brugia malayi Melatonin receptor type 1A 0.031 0.0605 0.059
Brugia malayi Dopamine receptor protein 1 0.031 0.0605 0.059
Leishmania major cathepsin L-like protease 0.0881 0.197 0.9235
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0547 0.117 0.117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0881 0.197 0.9557
Brugia malayi G protein-coupled receptor F59B2.13 0.031 0.0605 0.059
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0327 0.0645 0.1674
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0081 0.0057 0.0158
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Plasmodium falciparum cysteine proteinase falcipain 1 0.0474 0.0997 0.4828
Entamoeba histolytica cysteine proteinase, putative 0.0474 0.0997 0.4915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0604 0.1307 0.6333
Entamoeba histolytica hypothetical protein 0.0197 0.0334 0.1448
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.117 0.117
Brugia malayi hypothetical protein 0.031 0.0605 0.059
Brugia malayi ADAMTS-like protease 0.0145 0.021 0.0194
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0076 0.0043 0.0043
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0076 0.0043 0.0121
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Brugia malayi hypothetical protein 0.008 0.0053 0.0037
Echinococcus multilocularis RNA directed DNA polymerase 0.008 0.0053 0.0147
Trypanosoma cruzi WLM domain containing protein, putative 0.0327 0.0645 0.1674
Echinococcus granulosus tachykinin peptides receptor 99D 0.031 0.0605 0.1685
Schistosoma mansoni hypothetical protein 0.0067 0.0023 0.0023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0547 0.117 0.117
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Echinococcus granulosus cathepsin L cysteine proteinase 0.0881 0.197 0.5487
Echinococcus multilocularis rhodopsin orphan GPCR 0.031 0.0605 0.1685
Schistosoma mansoni hypothetical protein 0.092 0.2062 0.2062
Entamoeba histolytica cysteine protease, putative 0.0197 0.0334 0.1448
Brugia malayi reverse transcriptase 0.008 0.0053 0.0037
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0076 0.0043 0.0121
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.008 0.0053 0.0147
Brugia malayi Matrixin family protein 0.0069 0.0027 0.0011
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.117 0.117
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Loa Loa (eye worm) trypsin family protein 0.0547 0.117 0.1167
Loa Loa (eye worm) hypothetical protein 0.0327 0.0645 0.0641
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0197 0.0334 0.1604
Echinococcus granulosus notch 0.0186 0.0307 0.0855
Brugia malayi Kringle domain containing protein 0.053 0.113 0.1116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Echinococcus multilocularis serotonin receptor 0.0493 0.1041 0.2898
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.008 0.0053 0.0147
Echinococcus multilocularis Squalene phytoene synthase 0.0082 0.0059 0.0166
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0023 0.0007
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0239 0.0433 0.2954
Echinococcus multilocularis protein jagged 1 0.0186 0.0307 0.0855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0604 0.1307 0.6333
Brugia malayi hypothetical protein 0.008 0.0053 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2129 0.2531
Schistosoma mansoni egf-like domain protein 0.0347 0.0692 0.0692
Onchocerca volvulus 0.008 0.0053 0.004
Schistosoma mansoni opsin-like receptor 0.031 0.0605 0.0605
Schistosoma mansoni hypothetical protein 0.0067 0.0023 0.0023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0547 0.117 0.117
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0347 0.0692 0.0689
Echinococcus granulosus Upstream activation factor subunit UAF30 0.092 0.2062 0.5741
Brugia malayi Cathepsin L-like precursor 0.0881 0.197 0.1958
Echinococcus multilocularis neuropeptide receptor 0.031 0.0605 0.1685
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0076 0.0043 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0132 0.0178 0.0496
Brugia malayi AKH receptor 0.031 0.0605 0.059
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.016 0.0245 0.0229
Echinococcus multilocularis serotonin transporter 0.0323 0.0636 0.1771
Echinococcus granulosus rhodopsin orphan GPCR 0.031 0.0605 0.1685
Loa Loa (eye worm) hypothetical protein 0.0064 0.0016 0.0012
Brugia malayi G protein-coupled receptor 0.031 0.0605 0.059
Brugia malayi kinase, mitochondrial precursor 0.077 0.1705 0.1692
Echinococcus granulosus neuropeptide receptor 0.031 0.0605 0.1685
Loa Loa (eye worm) matrixin family protein 0.0069 0.0027 0.0023
Brugia malayi ORL1-like opioid receptor 0.031 0.0605 0.059
Echinococcus multilocularis protein jagged 1 0.0186 0.0307 0.0855
Toxoplasma gondii cathepsin CPL 0.0881 0.197 0.9557
Trypanosoma cruzi cysteine peptidase, putative 0.0881 0.197 0.542
Echinococcus multilocularis G protein coupled receptor 139 0.031 0.0605 0.1685
Onchocerca volvulus 0.0186 0.0307 0.0294
Schistosoma mansoni septate junction protein 0.0186 0.0307 0.0307
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0211 0.0368 0.0353
Entamoeba histolytica cysteine proteinase, putative 0.0604 0.1307 0.6533
Onchocerca volvulus 0.0076 0.0043 0.003
Echinococcus granulosus protein jagged 1 0.0186 0.0307 0.0855
Schistosoma mansoni notch 0.0186 0.0307 0.0307
Onchocerca volvulus 0.0186 0.0307 0.0294
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Schistosoma mansoni hypothetical protein 0.0547 0.117 0.117
Entamoeba histolytica cysteine proteinase, putative 0.0881 0.197 1
Loa Loa (eye worm) brahma associated protein 0.092 0.2062 0.2059
Giardia lamblia Cathepsin B precursor 0.0618 0.1341 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.092 0.2062 1
Brugia malayi Cathepsin L-like precursor 0.0881 0.197 0.1958
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0023 0.0063
Brugia malayi neuropeptide F receptor 0.031 0.0605 0.059
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.031 0.0605 0.0605
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1559 0.3591 1
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Schistosoma mansoni protein kinase 0.008 0.0053 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0474 0.0997 0.4828
Leishmania major cathepsin L-like protease 0.0948 0.2129 1
Schistosoma mansoni voltage-gated potassium channel 0.0174 0.0279 0.0279
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0547 0.117 0.117
Echinococcus multilocularis SWI:SNF matrix associated 0.092 0.2062 0.5741
Echinococcus granulosus alpha 1A adrenergic receptor 0.031 0.0605 0.1685
Echinococcus granulosus glycoprotein Antigen 5 0.0648 0.1413 0.3936
Echinococcus multilocularis adam 0.0136 0.0187 0.052
Echinococcus multilocularis neurogenic locus notch protein 0.0186 0.0307 0.0855
Onchocerca volvulus 0.031 0.0605 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.0334 0.1604
Onchocerca volvulus 0.0881 0.197 0.196
Echinococcus granulosus neuropeptide receptor A26 0.031 0.0605 0.1685
Trypanosoma cruzi major cysteine proteinase, putative 0.0197 0.0334 0.0794
Loa Loa (eye worm) hypothetical protein 0.053 0.113 0.1127
Brugia malayi follicle stimulating hormone receptor 0.0379 0.077 0.0755
Toxoplasma gondii preprocathepsin c precursor, putative 0.0307 0.0596 0.288
Trypanosoma brucei hypothetical protein, conserved 0.0327 0.0645 0.0722
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0881 0.197 0.9557
Brugia malayi Papain family cysteine protease containing protein 0.0881 0.197 0.1958
Schistosoma mansoni cathepsin s 0.0277 0.0526 0.0526
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0023 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.0334 0.1604
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Onchocerca volvulus 0.008 0.0053 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.031 0.0605 0.0605
Schistosoma mansoni biogenic amine receptor 0.031 0.0605 0.0605
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0076 0.0043 0.0043
Trypanosoma brucei unspecified product 0.0124 0.0158 0.0129
Trichomonas vaginalis reverse transcriptases, putative 0.008 0.0053 0.0238
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0327 0.0645 0.063
Echinococcus multilocularis allatostatin A receptor 0.031 0.0605 0.1685
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.008 0.0053 0.0147
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0618 0.1341 0.3641
Brugia malayi cathepsin F-like cysteine proteinase 0.0277 0.0526 0.0511
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Schistosoma mansoni hypothetical protein 0.0195 0.033 0.033
Brugia malayi Cathepsin L-like precursor 0.0881 0.197 0.1958
Schistosoma mansoni amine GPCR 0.0558 0.1198 0.1198
Schistosoma mansoni amine GPCR 0.031 0.0605 0.0605
Schistosoma mansoni hypothetical protein 0.0082 0.0059 0.0059
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0547 0.117 0.117
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0269 0.0507 0.2444
Toxoplasma gondii calcium binding egf domain-containing protein 0.0347 0.0692 0.3347
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Chlamydia trachomatis SWIB complex protein 0.092 0.2062 1
Loa Loa (eye worm) G-protein coupled receptor 0.031 0.0605 0.0602
Loa Loa (eye worm) hypothetical protein 0.0067 0.0023 0.0019
Entamoeba histolytica cysteine protease, putative 0.0474 0.0997 0.4915
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0076 0.0043 0.0194
Onchocerca volvulus 0.0881 0.197 0.196
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.031 0.0605 0.1685
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Echinococcus multilocularis nmda type glutamate receptor 0.0058 0.0001 0.0003
Onchocerca volvulus Neuropeptide F receptor homolog 0.031 0.0605 0.0593
Brugia malayi cathepsin L-like precursor 0.0604 0.1307 0.1293
Schistosoma mansoni hypothetical protein 0.0081 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0197 0.0334 0.033
Echinococcus granulosus hypothetical protein 0.1343 0.3074 0.8561
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Loa Loa (eye worm) hypothetical protein 0.0493 0.1041 0.1037
Trypanosoma cruzi hypothetical protein, conserved 0.053 0.113 0.3045
Plasmodium falciparum serine repeat antigen 4 0.0197 0.0334 0.1604
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0179 0.0291 0.0275
Schistosoma mansoni TRABID protein (C64 family) 0.0327 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Brugia malayi Cathepsin L-like precursor 0.0604 0.1307 0.1293
Brugia malayi Protein kinase domain containing protein 0.053 0.113 0.1116
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus granulosus g-protein coupled receptor 0.031 0.0605 0.1685
Trypanosoma brucei hypothetical protein, conserved 0.0124 0.0158 0.0129
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0197 0.0334 0.033
Schistosoma mansoni hypothetical protein 0.0547 0.117 0.117
Trypanosoma cruzi cruzipain precursor, putative 0.0277 0.0526 0.1338
Echinococcus multilocularis rhodopsin orphan GPCR 0.031 0.0605 0.1685
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.008 0.0053 0.0147
Echinococcus multilocularis g-protein coupled receptor 0.031 0.0605 0.1685
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus multilocularis cathepsin b 0.1559 0.3591 1
Loa Loa (eye worm) neuropeptide F receptor 0.031 0.0605 0.0602
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0327 0.0645 0.063
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.031 0.0605 0.0605
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0197 0.0334 0.033
Onchocerca volvulus 0.0186 0.0307 0.0294
Schistosoma mansoni opsin-like receptor 0.031 0.0605 0.0605
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.031 0.0605 0.1685
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0327 0.0645 0.1796
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0881 0.197 0.9557
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.031 0.0605 0.0602
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0197 0.0334 0.1604
Echinococcus multilocularis dro:myosuppressin receptor 0.031 0.0605 0.1685
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0327 0.0645 0.1674
Echinococcus multilocularis rhodopsin orphan GPCR 0.031 0.0605 0.1685
Onchocerca volvulus Neurogenic locus notch homolog 0.0186 0.0307 0.0295
Brugia malayi Papain family cysteine protease containing protein 0.0197 0.0334 0.0318
Echinococcus granulosus peptide allatostatin:somatostatin 0.031 0.0605 0.1685
Echinococcus granulosus g protein coupled receptor 0.031 0.0605 0.1685
Loa Loa (eye worm) hypothetical protein 0.0347 0.0692 0.0689
Trypanosoma brucei cysteine peptidase C (CPC) 0.0618 0.1341 0.1571
Schistosoma mansoni hypothetical protein 0.008 0.0053 0.0053
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.031 0.0605 0.1685
Echinococcus multilocularis rhodopsin orphan GPCR 0.031 0.0605 0.1685
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0197 0.0334 0.1448
Echinococcus granulosus biogenic amine 5HT receptor 0.031 0.0605 0.1685
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0198 0.0335 0.0933
Echinococcus granulosus rhodopsin orphan GPCR 0.031 0.0605 0.1685
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0239 0.0433 0.2088
Loa Loa (eye worm) cysteine protease 0.0881 0.197 0.1967
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0648 0.1413 0.1413
Echinococcus granulosus neuropeptide s receptor 0.031 0.0605 0.1685
Loa Loa (eye worm) hypothetical protein 0.0197 0.0334 0.033
Loa Loa (eye worm) hypothetical protein 0.0197 0.0334 0.033
Onchocerca volvulus 0.0604 0.1307 0.1295
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.031 0.0605 0.1685
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Brugia malayi brahma associated protein 60 kDa 0.092 0.2062 0.2049
Entamoeba histolytica cysteine proteinase, putative 0.0881 0.197 1
Leishmania major hypothetical protein, conserved 0.0327 0.0645 0.2829
Schistosoma mansoni cell polarity protein 0.0186 0.0307 0.0307
Plasmodium falciparum transporter, putative 0.0076 0.0043 0.0194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0881 0.197 0.9557
Brugia malayi G-protein coupled receptor 0.031 0.0605 0.059
Brugia malayi Calcium binding EGF domain containing protein 0.0347 0.0692 0.0678
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0076 0.0043 0.0194
Schistosoma mansoni notch 0.0186 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0197 0.0334 0.033
Giardia lamblia Cathepsin B precursor 0.0197 0.0334 0.2181
Brugia malayi Serotonin receptor 0.031 0.0605 0.059
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.4239 1 1
Echinococcus granulosus delta-like protein 1 0.0186 0.0307 0.0855
Brugia malayi Trypsin-like protease protein 5 0.0547 0.117 0.1156
Brugia malayi Metabotropic glutamate receptor precursor. 0.0067 0.0022 0.0007
Leishmania major developmentally regulated phosphoprotein-like protein 0.077 0.1705 0.7951
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0023 0.0063
Onchocerca volvulus 0.0547 0.117 0.1158
Onchocerca volvulus 0.031 0.0605 0.0593
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0239 0.0433 0.2954
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0307 0.0596 0.288
Schistosoma mansoni hypothetical protein 0.031 0.0605 0.0605
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0076 0.0043 0.0194
Loa Loa (eye worm) hypothetical protein 0.0179 0.0291 0.0287
Schistosoma mansoni hypothetical protein 0.0186 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0186 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0327 0.0645 0.0641
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0327 0.0645 0.1674
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Brugia malayi GnHR receptor homolog 0.031 0.0605 0.059
Echinococcus granulosus Squalene phytoene synthase 0.0082 0.0059 0.0166
Brugia malayi EGF-like domain containing protein 0.0186 0.0307 0.0291
Schistosoma mansoni hypothetical protein 0.0186 0.0307 0.0307
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0327 0.0645 0.063
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0881 0.197 0.9557
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.092 0.2062 1
Echinococcus multilocularis neuropeptide Y receptor 0.031 0.0605 0.1685
Loa Loa (eye worm) hypothetical protein 0.0493 0.1041 0.1037
Echinococcus multilocularis cathepsin L cysteine protease 0.0881 0.197 0.5487
Schistosoma mansoni biogenic amine receptor 0.031 0.0605 0.0605
Schistosoma mansoni cathepsin F (C01 family) 0.0881 0.197 0.197
Echinococcus multilocularis cathepsin L cysteine protease 0.0881 0.197 0.5487
Schistosoma mansoni neuropeptide receptor 0.031 0.0605 0.0605
Plasmodium falciparum beta-hydroxyacyl-ACP dehydratase 0.0064 0.0015 0.0055
Giardia lamblia Cathepsin L precursor 0.0197 0.0334 0.2181
Onchocerca volvulus Cathepsin L homolog 0.0881 0.197 0.196
Giardia lamblia High cysteine protein 0.0186 0.0307 0.1973
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.031 0.0605 0.0605
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0197 0.0334 0.0334
Schistosoma mansoni cercarial elastase (S01 family) 0.0547 0.117 0.117
Echinococcus granulosus cysteine protease 0.0474 0.0997 0.2777
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.031 0.0605 0.0605
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.031 0.0605 0.1685
Brugia malayi larval opioid receptor 0.031 0.0605 0.059
Schistosoma mansoni sodium/chloride dependent transporter 0.0323 0.0636 0.0636
Echinococcus multilocularis neurogenic locus protein delta 0.0186 0.0307 0.0855
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0639 0.1391 0.3873
Schistosoma mansoni pyruvate dehydrogenase 0.0727 0.1602 0.1602
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0076 0.0043 0.004
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.031 0.0605 0.0605
Onchocerca volvulus 0.0327 0.0645 0.0632
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0233 0.042 0.2021
Echinococcus granulosus laminin 0.0347 0.0692 0.1928
Echinococcus granulosus cathepsin L 0.0474 0.0997 0.2777
Plasmodium vivax vivapain-1 0.0474 0.0997 0.4828
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0269 0.0507 0.2161
Trypanosoma brucei ingi protein (ORF1) 0.0124 0.0158 0.0129
Brugia malayi Delta serrate ligand family protein 0.0186 0.0307 0.0291
Echinococcus granulosus cathepsin L 0.0197 0.0334 0.0929
Echinococcus granulosus sodium and chloride dependent glycine 0.0179 0.0291 0.081
Brugia malayi reverse transcriptase 0.008 0.0053 0.0037
Echinococcus multilocularis neural cadherin 0.0186 0.0307 0.0855
Onchocerca volvulus Putative cubilin 0.0186 0.0307 0.0294
Echinococcus multilocularis transient receptor potential cation channel 0.0168 0.0265 0.0737
Echinococcus granulosus Mastin 0.0648 0.1413 0.3936
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0186 0.0307 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.031 0.0605 0.1685
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0132 0.0178 0.0178
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0197 0.0334 0.0334
Schistosoma mansoni myosin xvIII 0.031 0.0605 0.0605
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0076 0.0043 0.0121
Echinococcus granulosus rhodopsin orphan GPCR 0.031 0.0605 0.1685
Echinococcus granulosus rhodopsin orphan GPCR 0.031 0.0605 0.1685
Onchocerca volvulus 0.0881 0.197 0.196
Loa Loa (eye worm) ctsf protein 0.0881 0.197 0.1967
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0197 0.0334 0.1604
Brugia malayi hypothetical protein 0.031 0.0605 0.059
Loa Loa (eye worm) hypothetical protein 0.0547 0.117 0.1167
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0197 0.0334 0.1604
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Plasmodium vivax unspecified product 0.0474 0.0997 0.4828
Echinococcus granulosus neural cadherin 0.0186 0.0307 0.0855
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.008 0.0053 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0881 0.197 0.9557
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1559 0.3591 0.3591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2129 0.2531
Echinococcus granulosus 7tm_1 domain containing protein 0.031 0.0605 0.1685
Echinococcus granulosus tm gpcr rhodopsin 0.0639 0.1391 0.3873
Entamoeba histolytica cysteine protease, putative 0.0881 0.197 1
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0547 0.117 0.3259
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0197 0.0334 0.0334
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0076 0.0043 0.0043
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0474 0.0997 0.0997
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Brugia malayi brahma associated protein 60 kDa 0.092 0.2062 0.2049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0881 0.197 0.9557
Leishmania major cysteine peptidase A (CPA) 0.0881 0.197 0.9235
Plasmodium falciparum serine repeat antigen 3 0.0197 0.0334 0.1604
Echinococcus multilocularis SWI:SNF matrix associated 0.092 0.2062 0.5741
Loa Loa (eye worm) reprolysin 0.0064 0.0016 0.0012
Loa Loa (eye worm) neuropeptide F receptor 0.031 0.0605 0.0602
Brugia malayi hypothetical protein 0.031 0.0605 0.059
Brugia malayi EGF-like domain containing protein 0.0186 0.0307 0.0291
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0145 0.0209 0.0999
Echinococcus multilocularis neuropeptide FF receptor 2 0.0456 0.0954 0.2657
Plasmodium falciparum cysteine proteinase falcipain 3 0.0881 0.197 0.9557
Schistosoma mansoni fusion 0.0327 0.0645 0.0645
Entamoeba histolytica cysteine proteinase, putative 0.0474 0.0997 0.4915
Brugia malayi Pao retrotransposon peptidase family protein 0.008 0.0053 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0197 0.0334 0.1604
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0327 0.0645 0.1796
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus granulosus cathepsin L cysteine protease 0.0474 0.0997 0.2777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2129 0.2531
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0547 0.117 0.3259
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0145 0.0405
Schistosoma mansoni hypothetical protein 0.0186 0.0307 0.0307
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0103 0.0109 0.0305
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0277 0.0526 0.0523
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.077 0.1705 0.4669
Echinococcus granulosus thyrotropin releasing hormone receptor 0.031 0.0605 0.1685
Brugia malayi cathepsin Z-like cysteine proteinase 0.0197 0.0334 0.0318
Echinococcus multilocularis rhodopsin orphan GPCR 0.031 0.0605 0.1685
Echinococcus granulosus biogenic amine 5HT receptor 0.0493 0.1041 0.2898
Brugia malayi putative neuropeptide receptor 0.031 0.0605 0.059
Brugia malayi Papain family cysteine protease containing protein 0.0474 0.0997 0.0983
Onchocerca volvulus 0.0881 0.197 0.196
Entamoeba histolytica cysteine protease, putative 0.0197 0.0334 0.1448
Trypanosoma cruzi WLM domain containing protein, putative 0.0327 0.0645 0.1674
Echinococcus multilocularis G-protein coupled receptor, putative 0.031 0.0605 0.1685
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.4239 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0132 0.0178 0.0496
Mycobacterium ulcerans hypothetical protein 0.0547 0.117 1
Echinococcus multilocularis ankyrin repeat protein 0.0153 0.0228 0.0636
Brugia malayi Papain family cysteine protease containing protein 0.0197 0.0334 0.0318
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0186 0.0307 0.0294
Schistosoma mansoni voltage-gated potassium channel 0.0174 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0277 0.0526 0.0523
Echinococcus granulosus sex peptide receptor 0.031 0.0605 0.1685
Echinococcus multilocularis sodium and chloride dependent glycine 0.0179 0.0291 0.081
Schistosoma mansoni hypothetical protein 0.0186 0.0307 0.0307
Plasmodium vivax cysteine repeat modular protein 1, putative 0.053 0.113 0.5474
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.031 0.0605 0.0602
Leishmania major cathepsin L-like protease 0.0948 0.2129 1
Giardia lamblia Cathepsin L precursor 0.0197 0.0334 0.2181
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.067 0.1465 0.3992
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0474 0.0997 0.4828
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0881 0.197 0.9557
Schistosoma mansoni transcription factor LCR-F1 0.0081 0.0057 0.0057
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.031 0.0605 0.1685
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.031 0.0605 0.0602
Loa Loa (eye worm) hypothetical protein 0.0473 0.0994 0.0991
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0076 0.0043 0.0121
Onchocerca volvulus 0.0327 0.0645 0.0632
Schistosoma mansoni cathepsin D (A01 family) 0.0174 0.0279 0.0279
Brugia malayi Cathepsin L-like cysteine proteinase 0.0604 0.1307 0.1293
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0323 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0186 0.0307 0.0303
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.008 0.0053 0.004
Toxoplasma gondii kringle domain-containing protein 0.053 0.113 0.5474
Schistosoma mansoni hypothetical protein 0.031 0.0605 0.0605
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0132 0.0178 0.0496
Echinococcus granulosus nmda type glutamate receptor 0.0058 0.0001 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0132 0.0178 0.0496
Toxoplasma gondii cathepsin B 0.0618 0.1341 0.6499
Brugia malayi Papain family cysteine protease containing protein 0.0474 0.0997 0.0983
Brugia malayi Cathepsin L-like precursor 0.0881 0.197 0.1958
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0474 0.0997 0.1151
Echinococcus granulosus ring and YY1 binding protein 0.0327 0.0645 0.1796
Echinococcus multilocularis neuropeptide receptor A26 0.031 0.0605 0.1685
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Schistosoma mansoni neuropeptide f receptor 76f 0.031 0.0605 0.0605
Onchocerca volvulus 0.031 0.0605 0.0593
Brugia malayi Dopamine receptor 0.031 0.0605 0.059
Loa Loa (eye worm) hypothetical protein 0.031 0.0605 0.0602
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0307 0.0596 0.288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.2129 0.2531
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0197 0.0334 0.0334
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0059 0.0004 0.001
Echinococcus multilocularis SWI:SNF matrix associated 0.092 0.2062 0.5741
Echinococcus granulosus allatostatin A receptor 0.031 0.0605 0.1685
Onchocerca volvulus 0.0547 0.117 0.1158
Echinococcus granulosus tissue type plasminogen activator 0.053 0.113 0.3147
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0327 0.0645 0.0722
Brugia malayi Zinc knuckle family protein 0.008 0.0053 0.0037
Echinococcus multilocularis neuropeptide Y receptor 0.031 0.0605 0.1685
Echinococcus multilocularis enteropeptidase 0.0648 0.1413 0.3936
Trypanosoma brucei RNA helicase, putative 0.351 0.8256 1
Brugia malayi hypothetical protein 0.031 0.0605 0.059
Loa Loa (eye worm) hypothetical protein 0.0277 0.0526 0.0523
Schistosoma mansoni notch 0.0186 0.0307 0.0307
Trypanosoma cruzi squalene synthase, putative 0.0264 0.0494 0.1248
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0327 0.0645 0.1674
Loa Loa (eye worm) hypothetical protein 0.0179 0.0291 0.0287

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 46 nM Inhibitory activity against human plasma renin ChEMBL. 3302256

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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