Detailed information for compound 1670279

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 290.316 | Formula: C18H14N2O2
  • H donors: 2 H acceptors: 2 LogP: 3.73 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)cccc2)N/N=C/c1ccccc1O
  • InChi: 1S/C18H14N2O2/c21-17-8-4-3-7-16(17)12-19-20-18(22)15-10-9-13-5-1-2-6-14(13)11-15/h1-12,21H,(H,20,22)/b19-12+
  • InChiKey: UDBPHZUMZVIFCA-XDHOZWIPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0014 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013 0.0023 0.0038
Onchocerca volvulus 0.0029 0.0094 0.0986
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0071 0.4131
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Onchocerca volvulus 0.0008 0.0003 0.0036
Schistosoma mansoni hypothetical protein 0.0019 0.0051 0.0051
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0094 0.018
Echinococcus multilocularis cpg binding protein 0.0023 0.007 0.051
Schistosoma mansoni smad1 5 8 and 0.001 0.001 0.001
Trichomonas vaginalis DNA polymerase eta, putative 0.0015 0.0032 0.0329
Brugia malayi CHE-14 protein 0.0051 0.0195 0.0195
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0195 0.1424
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0109 0.0455 0.0895
Mycobacterium ulcerans hypothetical protein 0.0029 0.0094 0.018
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0155 0.9315
Loa Loa (eye worm) jmjC domain-containing protein 0.0092 0.038 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0011 0.0519
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0003 0.0219
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0014 0.0101
Brugia malayi N-terminal motif family protein 0.0218 0.0944 0.0944
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Echinococcus multilocularis expressed conserved protein 0.0011 0.0014 0.0106
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0223 0.0434
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0013 0.0023 0.0038
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.002 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0041 0.015 0.015
Trypanosoma brucei unspecified product 0.001 0.0011 0.0519
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0062 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0062
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0015 0.0031 0.1836
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.002 0.015
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013 0.0023 0.1464
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.002 0.0214
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1133 0.5048 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013 0.0023 0.0038
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0003 0.0003
Schistosoma mansoni DNA polymerase eta 0.0015 0.0032 0.0032
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0051 0.0375
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.002 0.002
Echinococcus granulosus jumonji domain containing protein 0.0062 0.0245 0.1791
Leishmania major protein kinase, putative 0.0011 0.0014 0.0504
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0032 0.1871
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0236 0.0236
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0092 0.0674
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0146 0.0623 0.4556
Brugia malayi hypothetical protein 0.0011 0.0014 0.0014
Brugia malayi steroid hormone receptor 0.0012 0.002 0.002
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0499 0.3652
Loa Loa (eye worm) hypothetical protein 0.0051 0.0195 0.0195
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0071 0.4435
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0094 0.018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0092 0.0674
Schistosoma mansoni hypothetical protein 0.0041 0.015 0.015
Echinococcus multilocularis 0.0013 0.0023 0.0166
Onchocerca volvulus 0.0008 0.0003 0.0036
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0094 0.018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0055 0.0214 0.0214
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0051 0.294
Echinococcus granulosus expressed conserved protein 0.0112 0.0467 0.3415
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Brugia malayi nuclear receptor NHR-88 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0218 0.0944 0.0944
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0085 0.0625
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0011 0.0014 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.002 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0032 0.1871
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0092 0.0176
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.003
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0094 0.0094
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.003 0.003
Schistosoma mansoni phosphatidylserine receptor 0.0014 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0049 0.0186 0.0186
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0155 0.1604
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0051 0.0095
Entamoeba histolytica hypothetical protein 0.0042 0.0155 0.1604
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0105
Echinococcus multilocularis lysine specific demethylase 5A 0.0054 0.0208 0.1525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.002 0.002
Echinococcus granulosus Smad4 0.001 0.001 0.0071
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0092 0.0092
Brugia malayi MH2 domain containing protein 0.001 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0019 0.0051 0.0051
Echinococcus multilocularis dna polymerase kappa 0.0015 0.0032 0.0233
Schistosoma mansoni smad1 5 8 and 0.001 0.001 0.001
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0003 0.0219
Plasmodium falciparum JmjC domain-containing protein, putative 0.0014 0.003 0.166
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0013 0.0023 0.0038
Loa Loa (eye worm) cytochrome P450 0.0013 0.0023 0.0023
Echinococcus granulosus peregrin 0.0045 0.0166 0.1217
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0155 0.1604
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.002 0.002
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0013 0.0023 0.0038
Leishmania major protein kinase, putative 0.0011 0.0014 0.0504
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0223 0.0223
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0013 0.0023 0.0038
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0051 0.3306
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0062
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.0014 0.003 0.1234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0037
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0011 0.0014 0.0022
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0071 0.0133
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.0944 0.9888
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.002 0.002
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0013 0.0023 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0094 0.018
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0014 0.0101
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0094 0.018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.002 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.001 0.001
Brugia malayi Pre-SET motif family protein 0.0028 0.0092 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0066 0.0066
Brugia malayi Pre-SET motif family protein 0.0194 0.0835 0.0835
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0062 0.3577
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0728 0.5326
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0728 0.5326
Onchocerca volvulus 0.0022 0.0064 0.0671
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.002 0.015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0003 0.0219
Brugia malayi nuclear hormone receptor 0.0012 0.002 0.002
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.0223 0.0434
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0043 0.0157 0.0304
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.009 0.5788
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0011 0.0519
Schistosoma mansoni hypothetical protein 0.0049 0.0186 0.0186
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.0223 0.0434
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0032 0.205
Echinococcus granulosus dna polymerase kappa 0.0015 0.0032 0.0233
Echinococcus granulosus smad 0.001 0.001 0.0071
Schistosoma mansoni transcription factor btf3 0.0042 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0094 0.4141
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013 0.0023 0.0038
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0166 0.0166
Giardia lamblia PHD finger protein 15 0.0045 0.0166 0.1438
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0499 0.0499
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.006 0.006
Echinococcus granulosus cGMP dependent protein kinase 1 0.0011 0.0014 0.0106
Echinococcus multilocularis geminin 0.0205 0.0884 0.6466
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0499 0.3652
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0015 0.0031 0.1836
Schistosoma mansoni coup transcription factor 0.0012 0.002 0.002
Brugia malayi CXXC zinc finger family protein 0.0022 0.0064 0.0064
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0051 0.0375
Echinococcus multilocularis transcription factor btf3 0.0042 0.0155 0.1135
Brugia malayi PHD-finger family protein 0.0045 0.0166 0.0166
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013 0.0023 0.0038
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0045 0.0166 0.0166
Brugia malayi MH2 domain containing protein 0.001 0.001 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.003 0.003
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0003 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0014 0.0014
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.009 0.5788
Echinococcus granulosus GPCR family 2 0.0019 0.0051 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.002 0.002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0051 0.0375
Echinococcus multilocularis protein patched 0.0051 0.0195 0.1424
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0109 0.0455 0.0895
Schistosoma mansoni hypothetical protein 0.0013 0.0023 0.0023
Trypanosoma brucei unspecified product 0.0015 0.0032 0.1871
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0003
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0124 0.0124
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013 0.0023 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0014 0.0014
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.002 0.002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.002 0.015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0062
Brugia malayi hypothetical protein 0.0015 0.0033 0.0033
Brugia malayi Bromodomain containing protein 0.0045 0.0166 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.003 0.003
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0003 0.0003
Brugia malayi MH2 domain containing protein 0.0144 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013 0.0023 0.1273
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0223 0.0434
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0032 0.0329
Brugia malayi MH1 domain containing protein 0.001 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0049 0.0186 0.0186
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013 0.0023 0.0038
Schistosoma mansoni Smad4 0.001 0.001 0.001
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0013 0.0023 0.0038
Brugia malayi ecdysteroid receptor 0.0012 0.002 0.002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0015 0.0032 0.0056
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.002 0.0214
Brugia malayi MH1 domain containing protein 0.001 0.001 0.001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.002 0.015
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0071 0.4131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.002 0.002
Echinococcus multilocularis jumonji domain containing protein 0.0062 0.0245 0.1791
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.0124 0.0905
Toxoplasma gondii pantoate-beta-alanine ligase 0.1133 0.5048 1
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0166 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0032 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Echinococcus granulosus cpg binding protein 0.0023 0.007 0.051
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0195 0.0195
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0071 0.4556
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.002 0.002
Brugia malayi Cytochrome P450 family protein 0.0028 0.009 0.009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0223 0.0434
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0013 0.0093
Brugia malayi jmjC domain containing protein 0.0014 0.003 0.003
Echinococcus granulosus FTZ F1 alpha 0.0012 0.002 0.015
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0032 0.0056
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0094 0.0974
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0045 0.0166 0.0166
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.002 0.002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.002 0.015
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0092 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0032 0.205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.002 0.002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0015 0.0032 0.1296
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0032 0.0032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0051 0.0051
Plasmodium vivax JmjC domain containing protein 0.0014 0.003 0.166
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.002 0.015
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0094 0.0094
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0032 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.2236 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013 0.0023 0.0038
Echinococcus multilocularis protein dispatched 1 0.0058 0.0227 0.166
Echinococcus granulosus cGMP dependent protein kinase 0.0011 0.0014 0.0106
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0094 0.018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0092 0.0674
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0051 0.0375
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0003 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0012 0.002 0.002
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0013 0.0023 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0049 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.0124 0.0905
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.009 0.009
Echinococcus granulosus cGMP dependent protein kinase 1 0.0011 0.0014 0.0106
Treponema pallidum fructose-bisphosphate aldolase 0.0223 0.0967 0.5
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0014 0.003 0.0054
Brugia malayi jmjC domain containing protein 0.0014 0.003 0.003
Brugia malayi Cytochrome P450 family protein 0.0013 0.0023 0.0023
Plasmodium falciparum cGMP-dependent protein kinase 0.0011 0.0014 0.0678
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0094 0.0974
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.002 0.002
Schistosoma mansoni protein phosphatase 2C 0.0014 0.003 0.003
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.0035
Schistosoma mansoni patched 1 0.0051 0.0195 0.0195
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.002 0.002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0051 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0064 0.0064
Leishmania major cytochrome p450-like protein 0.0013 0.0023 0.0881
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0013 0.0023 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0155 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0094 0.4141
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013 0.0023 0.0038
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0155 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.009 0.0171
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0014 0.0014
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0014 0.003 0.003
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0312 0.1367 0.1367
Echinococcus granulosus lysine specific demethylase 6a 0.0014 0.003 0.0223
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0032 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0014 0.0101
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.002 0.002
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0062 0.5
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0155 0.9315
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.001 0.001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0005
Onchocerca volvulus 0.022 0.0955 1
Leishmania major cytochrome p450-like protein 0.0028 0.009 0.3942
Trypanosoma brucei cytochrome P450, putative 0.0028 0.009 0.5694
Schistosoma mansoni hypothetical protein 0.001 0.0013 0.0013
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0032 0.0233
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.002 0.015
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0036 0.0264
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0051 0.2185
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0094 0.0094
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.002 0.015
Mycobacterium leprae Conserved hypothetical protein 0.0013 0.0023 0.0038
Loa Loa (eye worm) Smad1 0.001 0.001 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0223 0.0967 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0014 0.0014
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0146 0.0623 0.4556
Trypanosoma brucei unspecified product 0.001 0.0011 0.0519
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0051 0.0374
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.2236 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0032 0.0032
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0062 0.0116
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.002 0.002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0032 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013 0.0023 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0155 0.1604
Brugia malayi Egg laying defective protein 4 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0036 0.0264
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.002 0.015
Echinococcus multilocularis dnaJ subfamily B 0.0312 0.1367 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.002 0.002
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0155 0.0155
Echinococcus multilocularis lysine specific demethylase 6a 0.0014 0.003 0.0223
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0014 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.002 0.002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0051 0.3156
Echinococcus multilocularis Smad4 0.001 0.001 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Brugia malayi AF-10 protein 0.0015 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0071 0.0071
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0023 0.1464
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0094 0.018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.0124 0.0905
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0032 0.1871
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0236 0.0236
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.001 0.001
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.1133 0.5048 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.002 0.002
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.001 0.0071
Plasmodium vivax SET domain protein, putative 0.0028 0.0092 0.5451
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0037 0.2078
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0155 1
Trichomonas vaginalis set domain proteins, putative 0.022 0.0955 0.9872
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0014 0.0014
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.002 0.015
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0094 0.018
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.0023 0.0038
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0105
Echinococcus multilocularis dna polymerase eta 0.0015 0.0032 0.0233
Brugia malayi hypothetical protein 0.0023 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0119 0.0499 0.0499
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0499 0.5162
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0195 0.1424
Loa Loa (eye worm) hypothetical protein 0.006 0.0236 0.0236
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0003 0.0035
Echinococcus multilocularis JmjC domain containing protein 4 0.0014 0.003 0.0223
Toxoplasma gondii PHD-finger domain-containing protein 0.0045 0.0166 0.0323
Echinococcus granulosus geminin 0.0205 0.0884 0.6466
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.002 0.015
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0013 0.0023 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.002 0.015
Schistosoma mansoni nuclear hormone receptor 0.0012 0.002 0.002
Schistosoma mansoni jumonji domain containing protein 0.0014 0.003 0.003
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0051 0.0095
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0032 0.0032
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0014 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0051 0.294
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.0035
Schistosoma mansoni dep domain containing protein 0.0011 0.0014 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0094 0.4141
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.0223 0.1628
Onchocerca volvulus 0.0012 0.002 0.0214
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013 0.0023 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0051 0.0374
Giardia lamblia Fructose-bisphosphate aldolase 0.0223 0.0967 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013 0.0023 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0051 0.0374
Echinococcus granulosus transcription factor btf3 0.0042 0.0155 0.1135
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.002 0.002
Plasmodium falciparum phd finger protein, putative 0.0045 0.0166 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0014 0.0014
Echinococcus granulosus JmjC domain containing protein 4 0.0014 0.003 0.0223
Leishmania major DNA polymerase eta, putative 0.0015 0.0032 0.1296
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0011 0.0519
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0071 0.4556
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0194 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013 0.0023 0.0038
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0023 0.0166
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.0179 0.0179
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0014 0.0101
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0014 0.0101
Leishmania major hypothetical protein, conserved 0.0023 0.0071 0.3071
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.002 0.002
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.001 0.0071
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0013 0.0023 0.0038
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013 0.0023 0.0038
Brugia malayi isocitrate dehydrogenase 0.0019 0.0051 0.0051
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0023 0.1464
Schistosoma mansoni smad1 5 8 and 0.001 0.001 0.001
Echinococcus granulosus jumonji domain containing 1A 0.0014 0.003 0.0223
Onchocerca volvulus 0.0008 0.0003 0.0036
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.002 0.002
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0071 0.4131
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0013 0.0023 0.0038
Schistosoma mansoni phd/f-box containing protein 0.0014 0.003 0.003
Echinococcus granulosus PHD finger protein rhinoceros 0.0045 0.0166 0.1217
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0013 0.0023 0.0038
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0613 0.0613
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0155 0.0301
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0051 0.3156
Schistosoma mansoni smad 0.001 0.001 0.001
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0013 0.0093
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0051 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0092 0.0092
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0613 0.0613
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0035 0.0124 0.0124
Loa Loa (eye worm) AGC/PKG protein kinase 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0062 0.0116
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0051 0.0051
Echinococcus granulosus dna polymerase eta 0.0015 0.0032 0.0233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Brugia malayi jmjC domain containing protein 0.0014 0.003 0.003
Echinococcus multilocularis PHD finger protein rhinoceros 0.0045 0.0166 0.1217
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0195 0.2013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0019 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.002 0.002
Brugia malayi Cytochrome P450 family protein 0.0028 0.009 0.009
Toxoplasma gondii PHD-finger domain-containing protein 0.0015 0.0031 0.0055
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0013 0.0023 0.0038
Leishmania major DNA polymerase kappa, putative 0.0015 0.0032 0.1296
Loa Loa (eye worm) hypothetical protein 0.0028 0.0092 0.0092
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0195 0.1424
Loa Loa (eye worm) hypothetical protein 0.0077 0.031 0.031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0055 0.0214 0.0214
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0003
Mycobacterium leprae putative cytochrome p450 0.0013 0.0023 0.0038
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0003 0.0219
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1133 0.5048 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0236 0.0236
Brugia malayi Smad1 0.001 0.001 0.001
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0051 0.3306
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.002 0.015
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0223 0.0223
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0011 0.0014 0.0106
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0014
Brugia malayi cytochrome P450 0.0013 0.0023 0.0023
Echinococcus multilocularis jumonji domain containing 1A 0.0014 0.003 0.0223
Leishmania major basic transcription factor 3a, putative 0.0042 0.0155 0.6924
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0062 0.3577
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0094 0.018
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0051 0.0375
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0051 0.0375
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.002 0.015
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0032 0.0233
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0015 0.0031 0.0055
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0023 0.0023
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0032 0.205
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0015 0.0032 0.0329
Brugia malayi jmjC domain containing protein 0.0055 0.0214 0.0214
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013 0.0023 0.0038
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0014 0.003 0.0054
Brugia malayi beta-NAC-like protein 0.0042 0.0155 0.0155
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0051 0.0095
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0014 0.0101
Toxoplasma gondii PHD-finger domain-containing protein 0.0045 0.0166 0.0323
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.0223 0.1628
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0051 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.002 0.002
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0094 0.018
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013 0.0023 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Schistosoma mansoni cpg binding protein 0.0022 0.0064 0.0064
Echinococcus multilocularis peregrin 0.0045 0.0166 0.1217
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0205 0.0884 0.0884
Loa Loa (eye worm) jmjC domain-containing protein 0.0055 0.0214 0.0214
Loa Loa (eye worm) CYP4Cod1 0.0028 0.009 0.009
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0014 0.003 0.1962
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0155 0.1604
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0094 0.0974
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0014 0.0145
Echinococcus multilocularis GPCR, family 2 0.0019 0.0051 0.0374
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0013 0.0023 0.0881
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0094 0.018
Brugia malayi DIX domain containing protein 0.0011 0.0014 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.001 0.0071
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0014 0.0101
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.002 0.015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.0124 0.0905
Echinococcus granulosus phd:f box containing protein 0.0014 0.003 0.0223
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013 0.0023 0.0038
Echinococcus multilocularis smad 0.001 0.001 0.0071
Brugia malayi Cytochrome P450 family protein 0.0013 0.0023 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0032 0.205
Onchocerca volvulus 0.0028 0.0092 0.0966
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.002 0.002
Echinococcus granulosus dnaJ subfamily B 0.0312 0.1367 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013 0.0023 0.0038
Onchocerca volvulus 0.0011 0.0014 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.002 0.015
Onchocerca volvulus 0.0008 0.0003 0.0036
Toxoplasma gondii hypothetical protein 0.0011 0.0014 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0105
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0014 0.003 0.1782
Schistosoma mansoni cpg binding protein 0.0023 0.007 0.007
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013 0.0023 0.0038
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0051 0.0051
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0013 0.0023 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0032 0.205
Schistosoma mansoni dishevelled 0.0011 0.0014 0.0014
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.002 0.015
Echinococcus multilocularis phd:f box containing protein 0.0014 0.003 0.0223
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0013 0.0023 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0124 0.0124
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.0223 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0223 0.0967 1
Schistosoma mansoni hypothetical protein 0.0045 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Schistosoma mansoni thyroid hormone receptor 0.0012 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0124 0.0124
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0016 0.0037 0.2078
Echinococcus multilocularis expressed conserved protein 0.0112 0.0467 0.3415
Schistosoma mansoni dishevelled 0.0011 0.0014 0.0014
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0013 0.0023 0.0038
Brugia malayi jmjC domain containing protein 0.0014 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0019 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Schistosoma mansoni cytochrome P450 0.0013 0.0023 0.0023
Onchocerca volvulus Alhambra homolog 0.0045 0.0166 0.1742
Echinococcus granulosus lysine specific demethylase 5A 0.0055 0.0214 0.1566
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0014 0.0101
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0109 0.0455 0.0895
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0035 0.0124 0.0124
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.002 0.002
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0014 0.003 0.1962
Schistosoma mansoni jumonji domain containing protein 0.0116 0.0488 0.0488
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.001 0.0071
Brugia malayi jmjC domain containing protein 0.0146 0.0623 0.0623
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0032 0.1871
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0005
Schistosoma mansoni cpg binding protein 0.0023 0.007 0.007
Brugia malayi hypothetical protein 0.0011 0.0014 0.0014
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.002 0.0214
Schistosoma mansoni hypothetical protein 0.0205 0.0884 0.0884
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0014 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.002 0.002
Brugia malayi PHD-finger family protein 0.0016 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0014 0.0101
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0032 0.0032
Leishmania major cytochrome p450-like protein 0.0013 0.0023 0.0881
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013 0.0023 0.0038

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 93 uM Antitrypanosomal activity against bloodstream form of Trypanosoma cruzi Y trypomastigotes infected in Swiss mouse ChEMBL. 22727447

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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