TDR Targets

Basic information

Technical information

TDR Targets ID: 1714326
Name: (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydro xy-5-methyl-6,7-dihydro-5H-cyclopenta[e]pyrim idin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino )propan-1-one
MW: 457.996 | Formula: C24H32ClN5O2
H donors: 2 H acceptors: 4 LogP: 2.46 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2c1[C@H](C)C[C@H]2O)c1ccc(cc1)Cl)C
InChi: 1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
InChiKey: GRZXWCHAXNAUHY-NSISKUIASA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]piperazin-1-yl]-3-(isopropylamino)propan-1-one
(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]-1-piperazinyl]-3-(isopropylamino)propan-1-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, cGMP-dependent, type I	Starlite/ChEMBL	References
Homo sapiens	v-akt murine thymoma viral oncogene homolog 2	Starlite/ChEMBL	References
Homo sapiens	v-akt murine thymoma viral oncogene homolog 3	Starlite/ChEMBL	References
Homo sapiens	v-akt murine thymoma viral oncogene homolog 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	cGMP-dependent protein kinase 2, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Neospora caninum	AGC kinase TgPKG1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	cGMP-dependent protein kinase-related	Get druggable targets OG5_127599	All targets in OG5_127599
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/PKG protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Theileria parva	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	expressed conserved protein	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium berghei	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Cryptosporidium parvum	cyclic nucleotide (cGMP)-dependent protein kinase with 3 cNMP binding domains and a Ser/Thr kinase domain	Get druggable targets OG5_127599	All targets in OG5_127599
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Babesia bovis	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Brugia malayi	Egg laying defective protein 4	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Cryptosporidium hominis	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127599	All targets in OG5_127599
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium knowlesi	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Entamoeba histolytica	protein kinase 2, putative	0.0084	0.0533	0.1304
Leishmania major	beta tubulin	0.0238	0.1929	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0195	0.0189
Trypanosoma brucei	zeta tubulin	0.0103	0.071	0.3678
Plasmodium falciparum	tubulin gamma chain	0.0238	0.1929	1
Echinococcus multilocularis	protein kinase c iota type	0.0043	0.0166	0.016
Echinococcus granulosus	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Giardia lamblia	Beta tubulin	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Echinococcus multilocularis	tubulin alpha	0.0238	0.1929	0.1924
Echinococcus multilocularis	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0238	0.1929	1
Leishmania major	alpha tubulin	0.0238	0.1929	1
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Trypanosoma brucei	DNA polymerase eta, putative	0.0058	0.0301	0.1558
Echinococcus multilocularis	tubulin beta 1 chain	0.0238	0.1929	0.1924
Toxoplasma gondii	beta tubulin	0.0238	0.1929	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Giardia lamblia	Beta tubulin	0.0238	0.1929	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0089	0.0578	0.0572
Echinococcus multilocularis	tubulin subunit beta	0.0238	0.1929	0.1924
Onchocerca volvulus		0.0077	0.0474	0.2897
Echinococcus multilocularis	expressed conserved protein	0.0046	0.0189	0.0183
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0043	0.0166	0.016
Echinococcus granulosus	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Schistosoma mansoni	alpha-glucosidase	0.0115	0.0816	0.081
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0238	0.1929	1
Leishmania major	beta tubulin	0.0238	0.1929	1
Entamoeba histolytica	protein kinase, putative	0.0131	0.096	0.2401
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0166	0.0658
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0195	0.0189
Plasmodium vivax	delta tubulin, putative	0.0103	0.071	0.3657
Leishmania major	alpha tubulin	0.0238	0.1929	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0238	0.1929	1
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.1929	0.1924
Plasmodium falciparum	tubulin delta chain, putative	0.0103	0.071	0.299
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0166	0.0658
Brugia malayi	p70 ribosomal S6 kinase beta	0.0126	0.0915	0.4727
Echinococcus multilocularis	nervana 2	0.0083	0.0522	0.0516
Echinococcus granulosus	tubulin alpha chain	0.0238	0.1929	0.1924
Plasmodium vivax	tubulin epsilon chain, putative	0.0238	0.1929	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0993	0.5132
Entamoeba histolytica	protein kinase, putative	0.0131	0.096	0.2401
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0036	0.0102	0.0096
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Entamoeba histolytica	tubulin family protein	0.0238	0.1929	0.4892
Leishmania major	DNA polymerase kappa, putative	0.0036	0.0102	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0103	0.071	0.3657
Echinococcus granulosus	alpha tubulin	0.0238	0.1929	0.1924
Echinococcus granulosus	serine:threonine protein kinase N2	0.0043	0.0166	0.016
Loa Loa (eye worm)	tubulin alpha chain	0.0238	0.1929	1
Onchocerca volvulus		0.0033	0.0076	0.0432
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0036	0.0102	0.0096
Echinococcus granulosus	lysosomal alpha glucosidase	0.0133	0.0985	0.0979
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0195	0.0189
Echinococcus granulosus	peroxisome assembly protein 26	0.0238	0.1929	0.1924
Echinococcus granulosus	polycomb protein SCMH1	0.0034	0.0079	0.0072
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0043	0.0166	0.0833
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0046	0.0189	0.0183
Echinococcus granulosus	tubulin alpha 3 chain	0.0238	0.1929	0.1924
Trichomonas vaginalis	tubulin alpha chain, putative	0.0238	0.1929	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0084	0.0533	0.2602
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0043	0.0166	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Schistosoma mansoni	tubulin subunit alpha	0.0238	0.1929	0.1924
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0038	0.0121	0.0115
Leishmania major	beta tubulin	0.0238	0.1929	1
Onchocerca volvulus		0.0033	0.0076	0.0432
Echinococcus granulosus	cGMP dependent protein kinase	0.0046	0.0189	0.0183
Trichomonas vaginalis	esterase, putative	0.0033	0.0076	0.0179
Leishmania major	alpha tubulin	0.0238	0.1929	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0238	0.1929	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0103	0.071	0.3657
Loa Loa (eye worm)	tubulin beta chain	0.0238	0.1929	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Giardia lamblia	Gamma tubulin	0.0238	0.1929	1
Entamoeba histolytica	tubulin family protein	0.0238	0.1929	0.4892
Brugia malayi	Tubulin beta chain	0.0134	0.0993	0.5132
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0089	0.0578	0.1419
Entamoeba histolytica	protein kinase, putative	0.0126	0.0915	0.2286
Echinococcus granulosus	tubulin subunit beta	0.0238	0.1929	0.1924
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Leishmania major	alpha tubulin	0.0238	0.1929	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0238	0.1929	0.1924
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0046	0.0189	0.0183
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0166	0.0833
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0083	0.0522	0.0516
Brugia malayi	MH2 domain containing protein	0.011	0.0776	0.4001
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0038	0.0121	0.0115
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0103	0.071	0.3885
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0238	0.1929	0.1924
Brugia malayi	protein kinase C II.	0.0043	0.0166	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0079	0.0377
Loa Loa (eye worm)	tubulin alpha 2	0.0134	0.0993	0.5132
Echinococcus granulosus	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0084	0.0533	0.0527
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.003	0.0042	0.0042
Leishmania major	beta tubulin	0.0238	0.1929	1
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0084	0.0533	0.0527
Trypanosoma cruzi	tubulin delta chain	0.0103	0.071	0.3536
Trypanosoma cruzi	epsilon tubulin, putative	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit alpha	0.0238	0.1929	0.1924
Leishmania major	beta tubulin	0.0238	0.1929	1
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Trypanosoma brucei	epsilon tubulin	0.0238	0.1929	1
Echinococcus granulosus	beta tubulin	0.0238	0.1929	0.1924
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0028	0.0026	0.002
Trichomonas vaginalis	tubulin alpha chain, putative	0.0134	0.0993	0.504
Loa Loa (eye worm)	tubulin alpha chain	0.0238	0.1929	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0089	0.0578	0.0572
Loa Loa (eye worm)	tubulin gamma chain	0.0238	0.1929	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0238	0.1929	1
Loa Loa (eye worm)	mbt repeat family protein	0.0034	0.0079	0.0377
Mycobacterium ulcerans	DNA polymerase IV	0.0036	0.0102	0.0407
Leishmania major	zeta tubulin, putative	0.0103	0.071	0.3536
Entamoeba histolytica	tubulin gamma chain	0.0238	0.1929	0.4892
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0166	0.0833
Loa Loa (eye worm)	alpha-tubulin	0.0238	0.1929	1
Toxoplasma gondii	AGC kinase	0.0126	0.0915	0.4727
Trypanosoma cruzi	zeta tubulin, putative	0.0103	0.071	0.3536
Echinococcus granulosus	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Echinococcus granulosus	tubulin beta 1 chain	0.0238	0.1929	0.1924
Schistosoma mansoni	sex comb on midleg homolog	0.0034	0.0079	0.0072
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Trichomonas vaginalis	tubulin, putative	0.0134	0.0993	0.504
Leishmania major	beta tubulin	0.0238	0.1929	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0076	0.0179
Loa Loa (eye worm)	MH2 domain-containing protein	0.011	0.0776	0.4001
Trypanosoma cruzi	tubulin gamma chain	0.0238	0.1929	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0033	0.0076	0.0363
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0036	0.0102	0.0096
Leishmania major	beta tubulin	0.0238	0.1929	1
Brugia malayi	Protein kinase domain containing protein	0.0131	0.096	0.4961
Echinococcus multilocularis	microtubule associated protein 2	0.1127	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0238	0.1929	0.4892
Echinococcus granulosus	tubulin alpha 1C chain	0.0238	0.1929	0.1924
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0195	0.0982
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0038	0.0121	0.0115
Schistosoma mansoni	microtubule-associated protein tau	0.1127	1	1
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0084	0.0533	0.2741
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0192	0.0966
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.0076	0.007
Trypanosoma brucei	alpha tubulin	0.0238	0.1929	1
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.071	0.3536
Trypanosoma brucei	alpha tubulin	0.0238	0.1929	1
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.1929	0.1924
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0089	0.0578	0.2841
Schistosoma mansoni	alpha glucosidase	0.003	0.0042	0.0036
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Loa Loa (eye worm)	tubulin beta chain	0.0103	0.071	0.3657
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.071	0.3536
Trypanosoma brucei	glucosidase, putative	0.003	0.0042	0.0219
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0042	0.0156	0.06
Echinococcus multilocularis	tubulin gamma 1 chain	0.0238	0.1929	0.1924
Trypanosoma cruzi	beta tubulin, putative	0.0238	0.1929	1
Echinococcus multilocularis	beta tubulin	0.0238	0.1929	0.1924
Brugia malayi	ImpB/MucB/SamB family protein	0.0036	0.0102	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Trypanosoma brucei	beta tubulin	0.0238	0.1929	1
Onchocerca volvulus		0.0204	0.1621	1
Plasmodium vivax	tubulin beta chain, putative	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit epsilon	0.0238	0.1929	0.1924
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0036	0.0102	0.0316
Echinococcus granulosus	tubulin alpha 1C chain	0.0238	0.1929	0.1924
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0038	0.0121	0.0115
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0131	0.096	0.4961
Echinococcus granulosus	dna polymerase eta	0.0058	0.0301	0.0294
Brugia malayi	tubulin alpha chain - mouse	0.0238	0.1929	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.003	0.0042	0.0036
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0134	0.0993	0.5132
Mycobacterium ulcerans	hypothetical protein	0.0045	0.0178	0.1615
Leishmania major	hypothetical protein, conserved	0.0033	0.0076	0.0179
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0133	0.0976	0.0971
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0103	0.071	0.3536
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Trichomonas vaginalis	tubulin gamma chain, putative	0.0238	0.1929	1
Leishmania major	beta tubulin	0.0238	0.1929	1
Leishmania major	DNA polymerase eta, putative	0.0058	0.0301	0.1369
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0103	0.071	0.3536
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Echinococcus granulosus	Glutaredoxin protein 5	0.0083	0.0522	0.0516
Trypanosoma cruzi	zeta tubulin, putative	0.0103	0.071	0.3536
Echinococcus granulosus	tubulin beta 4A class IVa	0.0238	0.1929	0.1924
Loa Loa (eye worm)	transcription factor SMAD2	0.011	0.0776	0.4001
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0043	0.0166	0.0833
Leishmania major	alpha tubulin	0.0238	0.1929	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0076	0.0179
Entamoeba histolytica	tubulin alpha-1 chain	0.0238	0.1929	0.4892
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0126	0.0915	0.4727
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0036	0.0102	0.0195
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Leishmania major	beta tubulin	0.0238	0.1929	1
Leishmania major	gamma-tubulin	0.0238	0.1929	1
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0084	0.0533	0.1977
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0133	0.0985	0.5088
Echinococcus granulosus	protein kinase c iota type	0.0043	0.0166	0.016
Trypanosoma brucei	alpha tubulin, putative	0.0134	0.0993	0.5148
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Echinococcus granulosus	tubulin delta chain	0.0103	0.071	0.0704
Leishmania major	alpha tubulin	0.0238	0.1929	1
Schistosoma mansoni	alpha tubulin	0.0238	0.1929	0.1924
Echinococcus granulosus	tubulin gamma 1 chain	0.0238	0.1929	0.1924
Schistosoma mansoni	tubulin subunit alpha	0.0238	0.1929	0.1924
Brugia malayi	Tubulin alpha-2 chain	0.0238	0.1929	1
Brugia malayi	Tubulin beta-1 chain	0.0238	0.1929	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0238	0.1929	0.1924
Leishmania major	delta tubulin, putative	0.0103	0.071	0.3536
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0238	0.1929	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0238	0.1929	0.1924
Onchocerca volvulus		0.0134	0.0993	0.6113
Echinococcus granulosus	tubulin alpha chain	0.0238	0.1929	0.1924
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Leishmania major	DNA polymerase eta, putative	0.0033	0.0074	0.0169
Schistosoma mansoni	tubulin subunit alpha	0.0103	0.071	0.0704
Echinococcus granulosus	protein kinase c epsilon type	0.0043	0.0166	0.016
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0046	0.0189	0.0952
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.003	0.0042	0.0187
Trypanosoma cruzi	alpha tubulin, putative	0.0238	0.1929	1
Echinococcus multilocularis	beta tubulin	0.0238	0.1929	0.1924
Echinococcus granulosus	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0032	0.006	0.0277
Toxoplasma gondii	alpha tubulin TUBA1	0.0238	0.1929	1
Brugia malayi	tubulin alpha-2 chain	0.0238	0.1929	1
Schistosoma mansoni	sex comb on midleg homolog	0.0034	0.0079	0.0072
Echinococcus multilocularis	hypothetical protein	0.0238	0.1929	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Trypanosoma brucei	epsilon tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	tubulin alpha 2	0.0134	0.0993	0.5132
Trichomonas vaginalis	tubulin gamma chain, putative	0.0103	0.071	0.3536
Echinococcus multilocularis	dna polymerase kappa	0.0036	0.0102	0.0096
Echinococcus multilocularis	tubulin alpha 3 chain	0.0238	0.1929	0.1924
Brugia malayi	Tubulin alpha-2 chain	0.0238	0.1929	1
Echinococcus granulosus	NDR protein kinase	0.0043	0.0166	0.016
Leishmania major	alpha tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0036	0.0102	0.0497
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0133	0.0985	0.5088
Trypanosoma brucei	beta tubulin	0.0238	0.1929	1
Trypanosoma brucei	alpha tubulin	0.0238	0.1929	1
Trypanosoma cruzi	Protein kinase B	0.0089	0.0578	0.2841
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0046	0.0189	0.0183
Trypanosoma cruzi	tubulin delta chain	0.0103	0.071	0.3536
Trypanosoma brucei	beta tubulin	0.0238	0.1929	1
Onchocerca volvulus		0.0034	0.0079	0.0449
Brugia malayi	Hr1 repeat family protein	0.0043	0.0166	0.0833
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Schistosoma mansoni	serine/threonine kinase	0.0043	0.0166	0.016
Echinococcus granulosus	Protein kinase C brain isozyme	0.0043	0.0166	0.016
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0102	0.0528
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0195	0.0982
Echinococcus granulosus	dna polymerase kappa	0.0036	0.0102	0.0096
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Loa Loa (eye worm)	beta-tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0046	0.0192	0.0966
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0043	0.0166	0.016
Leishmania major	beta tubulin	0.0238	0.1929	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0036	0.0102	0.0316
Schistosoma mansoni	alpha tubulin	0.0238	0.1929	0.1924
Trypanosoma brucei	beta tubulin	0.0238	0.1929	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0036	0.0102	0.0096
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0134	0.0993	0.504
Echinococcus multilocularis	nervana 2	0.0083	0.0522	0.0516
Schistosoma mansoni	atypical protein kinase C	0.0043	0.0166	0.016
Echinococcus multilocularis	tubulin alpha 3 chain	0.0238	0.1929	0.1924
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0195	0.0189
Plasmodium falciparum	alpha tubulin 2	0.0238	0.1929	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0103	0.071	1
Echinococcus granulosus	nervana 2	0.0083	0.0522	0.0516
Brugia malayi	Tubulin beta chain	0.0103	0.071	0.3657
Brugia malayi	beta-tubulin, identical	0.0238	0.1929	1
Giardia lamblia	Kinase, AGC PKA	0.0084	0.0533	0.2361
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Trypanosoma brucei	tubulin delta chain	0.0103	0.071	0.3678
Trichomonas vaginalis	penicillin-binding protein, putative	0.0033	0.0076	0.0179
Trichomonas vaginalis	penicillin-binding protein, putative	0.0033	0.0076	0.0179
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0179	0.1397	0.723
Schistosoma mansoni	hypothetical protein	0.0204	0.1629	0.1624
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0103	0.071	0.3657
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0103	0.071	0.5
Echinococcus multilocularis	dna polymerase eta	0.0058	0.0301	0.0294
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Trichomonas vaginalis	tubulin alpha chain, putative	0.0134	0.0993	0.504
Echinococcus granulosus	beta LACTamase domain containing family member	0.0033	0.0076	0.007
Mycobacterium leprae	cell division protein FtsZ	0.0103	0.071	1
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Echinococcus granulosus	serine/threonine protein kinase	0.0089	0.0578	0.0572
Loa Loa (eye worm)	tubulin beta-4 chain	0.0238	0.1929	1
Plasmodium falciparum	tubulin beta chain	0.0238	0.1929	1
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0189	0.0183
Leishmania major	alpha tubulin	0.0238	0.1929	1
Leishmania major	beta tubulin	0.0238	0.1929	1
Echinococcus granulosus	neutral alpha glucosidase AB	0.003	0.0042	0.0036
Mycobacterium ulcerans	DNA polymerase IV	0.0036	0.0102	0.0407
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0043	0.0166	0.016
Leishmania major	alpha tubulin	0.0238	0.1929	1
Brugia malayi	mbt repeat family protein	0.0034	0.0079	0.0377
Leishmania major	beta tubulin	0.0238	0.1929	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.003	0.0042	0.0187
Brugia malayi	Pre-SET motif family protein	0.0179	0.1397	0.723
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0103	0.071	0.3657
Trichomonas vaginalis	DNA polymerase eta, putative	0.0036	0.0102	0.0316
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0034	0.0079	0.0449
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0028	0.0026	0.002
Echinococcus granulosus	histone acetyltransferase MYST2	0.0038	0.0121	0.0115
Brugia malayi	beta-lactamase family protein	0.0033	0.0076	0.0363
Leishmania major	epsilon tubulin, putative	0.0238	0.1929	1
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0046	0.0189	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0076	0.0363
Plasmodium falciparum	tubulin epsilon chain, putative	0.0238	0.1929	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0238	0.1929	1
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0043	0.0166	0.0833
Echinococcus multilocularis	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Trypanosoma brucei	epsilon tubulin	0.0238	0.1929	1
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Brugia malayi	beta-lactamase	0.0033	0.0076	0.0363
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0102	0.0528
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0076	0.0363
Echinococcus granulosus	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Trichomonas vaginalis	AGC family protein kinase	0.0043	0.0166	0.0658
Toxoplasma gondii	alpha-tubulin I, putative	0.0238	0.1929	1
Toxoplasma gondii	beta-tubulin, putative	0.0238	0.1929	1
Echinococcus multilocularis	tubulin delta chain	0.0103	0.071	0.0704
Trypanosoma brucei	zeta tubulin, putative	0.0103	0.071	0.3678
Echinococcus multilocularis	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Brugia malayi	Tubulin gamma chain	0.0238	0.1929	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0238	0.1929	1
Leishmania major	alpha tubulin	0.0238	0.1929	1
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0043	0.0166	0.016
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0043	0.0166	0.0833
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0195	0.0189
Plasmodium vivax	tubulin alpha chain, putative	0.0238	0.1929	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0083	0.0522	0.0516
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0036	0.0102	0.0316
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.1929	0.1924
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0103	0.071	0.3536
Echinococcus granulosus	protein kinase C gamma type	0.0043	0.0166	0.016
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0133	0.0976	0.0971
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0034	0.0079	0.0072
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0038	0.0121	0.0596
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0043	0.0166	0.016
Trypanosoma brucei	alpha tubulin	0.0238	0.1929	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0043	0.0166	0.016
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0036	0.0102	0.0316
Giardia lamblia	Alpha-tubulin	0.0238	0.1929	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0043	0.0166	0.016
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0046	0.0192	0.0966
Entamoeba histolytica	protein kinase, putative	0.0043	0.0166	0.0361
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0134	0.0993	0.504
Echinococcus granulosus	tubulin subunit TubB	0.0238	0.1929	0.1924
Giardia lamblia	Alpha-tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0166	0.0833
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0133	0.0985	0.0979
Leishmania major	beta tubulin	0.0238	0.1929	1
Toxoplasma gondii	ABC1 family protein	0.0033	0.0076	0.0363
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.096	0.4865
Leishmania major	beta tubulin	0.0238	0.1929	1
Trypanosoma brucei	beta tubulin	0.0238	0.1929	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0089	0.0578	0.0572
Plasmodium vivax	tubulin gamma chain, putative	0.0238	0.1929	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0134	0.0993	0.504
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0076	0.0179
Echinococcus multilocularis	polycomb protein SCMH1	0.0034	0.0079	0.0072
Trypanosoma brucei	unspecified product	0.0036	0.0102	0.0528
Entamoeba histolytica	hypothetical protein	0.0456	0.3916	1
Plasmodium falciparum	alpha tubulin 1	0.0238	0.1929	1
Giardia lamblia	Epsilon tubulin	0.0103	0.071	0.3325
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0102	0.0528
Brugia malayi	Egg laying defective protein 4	0.0046	0.0189	0.0952
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0238	0.1929	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0238	0.1929	1
Treponema pallidum	cell division protein FtsZ	0.0103	0.071	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0238	0.1929	1
Echinococcus granulosus	tubulin alpha chain	0.0238	0.1929	0.1924
Echinococcus granulosus	nervana 2	0.0083	0.0522	0.0516
Echinococcus multilocularis	tubulin subunit TubB	0.0238	0.1929	0.1924
Leishmania major	beta tubulin	0.0238	0.1929	1
Echinococcus multilocularis	tubulin alpha chain	0.0238	0.1929	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0121	0.0596
Plasmodium vivax	tubulin alpha chain, putative	0.0238	0.1929	1
Trypanosoma brucei	hypothetical protein, conserved	0.0033	0.0076	0.0395
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0189	0.0183
Echinococcus granulosus	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Brugia malayi	Tubulin alpha chain	0.0103	0.071	0.3657
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0046	0.0189	0.0952
Brugia malayi	hypothetical protein	0.0028	0.0026	0.0103
Brugia malayi	alpha-tubulin	0.0238	0.1929	1
Leishmania major	alpha tubulin	0.0238	0.1929	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0238	0.1929	0.1924
Leishmania major	beta tubulin	0.0238	0.1929	1
Brugia malayi	beta-lactamase family protein	0.0033	0.0076	0.0363
Schistosoma mansoni	hypothetical protein	0.0032	0.006	0.0053
Echinococcus granulosus	tubulin alpha chain	0.0238	0.1929	0.1924
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0238	0.1929	1
Leishmania major	beta tubulin	0.0238	0.1929	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0195	0.0189
Trichomonas vaginalis	AGC family protein kinase	0.0048	0.0211	0.0896
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.003	0.0042	0.0042
Trypanosoma brucei	tubulin gamma chain	0.0238	0.1929	1
Echinococcus granulosus	serine threonine protein kinase nrc	0.0084	0.0533	0.0527
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0034	0.0079	0.0072
Schistosoma mansoni	alpha tubulin	0.0238	0.1929	0.1924
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.0076	0.007
Giardia lamblia	Delta tubulin	0.0103	0.071	0.3325
Brugia malayi	mbt repeat family protein	0.0034	0.0079	0.0377
Loa Loa (eye worm)	BEN-1 protein	0.0238	0.1929	1
Loa Loa (eye worm)	BEN-1 protein	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit beta	0.0103	0.071	0.0704
Echinococcus multilocularis	protein kinase c epsilon type	0.0043	0.0166	0.016
Loa Loa (eye worm)	alpha-tubulin	0.0238	0.1929	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0301	0.153
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0033	0.0076	0.0363
Loa Loa (eye worm)	tubulin beta-1 chain	0.0238	0.1929	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.0074	0.0169
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Trichomonas vaginalis	tubulin, putative	0.0134	0.0993	0.504
Trypanosoma cruzi	DNA polymerase eta, putative	0.0058	0.0301	0.1369
Schistosoma mansoni	hypothetical protein	0.0028	0.0026	0.002
Brugia malayi	latrophilin 2 splice variant baaae	0.0032	0.006	0.0277
Trichomonas vaginalis	tubulin, putative	0.0238	0.1929	1
Leishmania major	beta tubulin	0.0238	0.1929	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0195	0.0189
Echinococcus granulosus	tubulin alpha	0.0238	0.1929	0.1924
Brugia malayi	Cell division protein ftsZ	0.0103	0.071	0.3657
Loa Loa (eye worm)	MBCTL1	0.0038	0.0121	0.0596
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0043	0.0166	0.016
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0036	0.0102	0.0158
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0089	0.0578	0.1419
Schistosoma mansoni	alpha-glucosidase	0.0115	0.0816	0.081
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0036	0.0102	0.0316
Trichomonas vaginalis	tubulin beta chain, putative	0.0134	0.0993	0.504
Onchocerca volvulus		0.0033	0.0076	0.0432
Echinococcus multilocularis	tubulin alpha 1C chain	0.0238	0.1929	0.1924
Brugia malayi	Tubulin alpha chain	0.0238	0.1929	1
Schistosoma mansoni	tubulin subunit beta	0.0238	0.1929	0.1924
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0043	0.0166	0.016
Schistosoma mansoni	transcription factor LCR-F1	0.0028	0.0026	0.002
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0076	0.0179
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0036	0.0102	0.0316
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0033	0.0074	0.0353
Schistosoma mansoni	DNA polymerase eta	0.0058	0.0301	0.0294
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0043	0.0166	0.016
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0036	0.0102	0.0158
Echinococcus multilocularis	Tubulin beta 2C chain	0.0238	0.1929	0.1924
Brugia malayi	ImpB/MucB/SamB family protein	0.0058	0.0301	0.153
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0133	0.0985	0.0979
Giardia lamblia	Beta tubulin	0.0238	0.1929	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0213	0.1707	1
Echinococcus granulosus	beta tubulin	0.0238	0.1929	0.1924
Schistosoma mansoni	tubulin subunit delta	0.0103	0.071	0.0704
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0043	0.0166	0.0833
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016
Echinococcus multilocularis	tubulin epsilon chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	serine threonine protein kinase	0.0043	0.0166	0.016
Leishmania major	alpha tubulin	0.0238	0.1929	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.003	0.0042	0.0187
Loa Loa (eye worm)	beta-lactamase	0.0033	0.0076	0.0363
Trichomonas vaginalis	set domain proteins, putative	0.0204	0.1621	0.8365
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0046	0.0192	0.0966
Trichomonas vaginalis	tubulin, putative	0.0103	0.071	0.3536
Echinococcus granulosus	SAM and MBT domain containing protein	0.0034	0.0079	0.0072
Echinococcus granulosus	tubulin epsilon chain	0.0238	0.1929	0.1924
Trichomonas vaginalis	tubulin beta chain, putative	0.0238	0.1929	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0076	0.0179
Echinococcus granulosus	tubulin alpha chain	0.0238	0.1929	0.1924
Echinococcus multilocularis	Glutaredoxin protein 5	0.0083	0.0522	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1929	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0131	0.096	0.4978
Schistosoma mansoni	tubulin subunit gamma	0.0238	0.1929	0.1924
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0033	0.0076	0.007
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0102	0.0528
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.0166	0.016

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (ADMET)	>= 20 %	Toxicity in nu/nu mouse xenografted with human PC3 cells assessed as loss in body weight at 150 mg/kg, po qd after 8 days relative to vehicle-treated control	ChEMBL.	22934575
IC50 (binding)	= 5 nM	Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluorescence labeled substrate after 60 mins by fluorescence polarization assay in presence of ATP	ChEMBL.	22934575
IC50 (binding)	= 8 nM	Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluorescence labeled Crosstide as substrate after 60 mins by fluorescence polarization assay in presence of ATP	ChEMBL.	22934575
IC50 (binding)	= 18 nM	Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluorescence labeled substrate after 60 mins by fluorescence polarization assay in presence of ATP	ChEMBL.	22934575
IC50 (binding)	= 69 nM	Inhibition of PRKG1beta	ChEMBL.	22934575
IC50 (binding)	= 98 nM	Inhibition of PRKG1alpha	ChEMBL.	22934575
IC50 (binding)	= 157 nM	Inhibition of Akt1 in human LNCAP cells assessed as phosphorylation of PRAS40 at Thr246 after 1.5 hrs	ChEMBL.	22934575
IC50 (functional)	= 1 uM	Cytotoxicity against human BT474M1 cells assessed as decrease in cell viability after 96 hrs by CellTitre-Glo assay	ChEMBL.	22934575
Inhibition (binding)		Inhibition of Akt1-mediated PRAS40 phosphorylation in human PC3 cells	ChEMBL.	22934575
Inhibition (binding)		Inhibition of Akt1-mediated PRAS40 phosphorylation in human LNCAP cells	ChEMBL.	22934575
Inhibition (binding)		Inhibition of Akt1-mediated PRAS40 phosphorylation in human MCF7 cells overexpressing Her2	ChEMBL.	22934575
Inhibition (binding)		Inhibition of Akt1-mediated PRAS40 phosphorylation in human BT474M1 cells	ChEMBL.	22934575
Inhibition (binding)	> 70 %	Inhibition of PRKG1beta at 1 uM	ChEMBL.	22934575
Inhibition (binding)	> 70 %	Inhibition of PRKG1alpha at 1 uM	ChEMBL.	22934575
MED (functional)	= 25 mg kg-1	Antitumor activity against human PC3 xenografted in po dosed nu/nu mouse assessed as inhibition of tumor growth administered once daily measured after 11 days	ChEMBL.	22934575

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	22934575

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2177390

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1714326