Detailed information for compound 1735698

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 530.615 | Formula: C30H34N4O5
  • H donors: 2 H acceptors: 2 LogP: 3.81 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCNC(=O)OCc1c(COC(=O)NCC)c2n(c1c1ccc(cc1)OC)Cc1c(C2)c2ccccc2n1C
  • InChi: 1S/C30H34N4O5/c1-5-31-29(35)38-17-23-24(18-39-30(36)32-6-2)28(19-11-13-20(37-4)14-12-19)34-16-27-22(15-26(23)34)21-9-7-8-10-25(21)33(27)3/h7-14H,5-6,15-18H2,1-4H3,(H,31,35)(H,32,36)
  • InChiKey: OSYCVMIULRGAIQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0272 0.0628
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0051 0.062 1
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Loa Loa (eye worm) sugar transporter 0.0019 0.0136 0.0122
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0078 0.0527
Trichomonas vaginalis myo-inositol transporter, putative 0.0019 0.0136 0.0054
Brugia malayi Pre-SET motif family protein 0.0028 0.0272 0.0423
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0046 0.054 0.084
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0025 0.0232 0.0576
Schistosoma mansoni hypothetical protein 0.0013 0.0058 0.0017
Plasmodium vivax pyruvate kinase 2, putative 0.0016 0.0097 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.004 0.046 0.1167
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Brugia malayi Major Facilitator Superfamily protein 0.0019 0.0136 0.0212
Echinococcus multilocularis neuropeptide s receptor 0.039 0.5643 0.5617
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.004 0.0447 0.9644
Leishmania major protein kinase, putative 0.004 0.046 0.7167
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0046 0.0545 1
Brugia malayi hypothetical protein 0.0443 0.6427 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0298 0.0376
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Loa Loa (eye worm) Smad1 0.0014 0.0075 0.0026
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0287 0.0447
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0394 0.0528
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0078 0.0122
Mycobacterium ulcerans sugar transporter 0.0019 0.0136 0.1226
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0019 0.0136 0.1226
Echinococcus multilocularis solute carrier family 22 0.0019 0.0136 0.0078
Loa Loa (eye worm) hypothetical protein 0.0034 0.0371 0.049
Chlamydia trachomatis lysine--tRNA ligase 0.0029 0.0297 0.9107
Leishmania major glucose transporter, lmgt1 0.0041 0.0467 0.7302
Loa Loa (eye worm) sugar transporter 0.0132 0.1815 0.2758
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0311 0.0639
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0022 0.0183 0.0392
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.004 0.046 0.063
Toxoplasma gondii sugar transporter ST2 0.0019 0.0136 0.0108
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.046 0.0403
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0132 0.1815 0.2758
Onchocerca volvulus 0.009 0.1201 0.3568
Plasmodium falciparum pyruvate kinase 2 0.0016 0.0097 0.0023
Trypanosoma brucei glucose transporter 1E 0.0041 0.0467 0.8428
Giardia lamblia Sugar-proton symporter 0.0019 0.0136 0.1122
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.062 1
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0311 0.0639
Schistosoma mansoni sugar transporter 0.0019 0.0136 0.0239
Plasmodium vivax sugar transporter, putative 0.0019 0.0136 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0311 0.5262
Loa Loa (eye worm) hypothetical protein 0.0022 0.0181 0.0193
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0014 0.0075 0.0064
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0022 0.0183 0.0197
Echinococcus granulosus pyruvate kinase 0.0031 0.032 0.041
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.0075 0.0026
Toxoplasma gondii facilitative glucose transporter GT1 0.0132 0.1815 0.3275
Echinococcus granulosus survival motor neuron protein 1 0.0443 0.6427 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0102 0.0068
Plasmodium falciparum calcium-dependent protein kinase 2 0.004 0.046 0.0472
Toxoplasma gondii aldehyde dehydrogenase 0.0051 0.062 0.1022
Echinococcus multilocularis synaptic vesicle 2 protein 0.0019 0.0136 0.0078
Echinococcus granulosus Smad4 0.0014 0.0075 0.0026
Mycobacterium ulcerans beta-lactamase 0.003 0.0311 0.4403
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.046 0.0403
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0029 0.0298 0.0703
Onchocerca volvulus 0.022 0.3119 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.004 0.046 0.0472
Loa Loa (eye worm) pyruvate kinase 0.0031 0.032 0.041
Echinococcus granulosus pyruvate kinase 0.0016 0.0097 0.006
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0078 0.0527
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0051 0.062 0.2038
Entamoeba histolytica pyruvate kinase, putative 0.0022 0.0181 0.1804
Loa Loa (eye worm) hypothetical protein 0.003 0.0311 0.0397
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.004 0.046 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0136 0.0054
Entamoeba histolytica hypothetical protein 0.0022 0.0183 0.1852
Leishmania major pyruvate kinase 0.0031 0.032 0.4707
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0031 0.032 0.0908
Toxoplasma gondii sugar transporter ST1 0.0019 0.0136 0.0108
Schistosoma mansoni sex comb on midleg homolog 0.004 0.0458 0.1162
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0029 0.0296 0.0373
Trypanosoma cruzi hexose transporter, putative 0.0041 0.0467 0.8428
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Echinococcus multilocularis pyruvate kinase 0.0024 0.0223 0.0166
Trichomonas vaginalis esterase, putative 0.003 0.0311 0.0639
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.031 0.0254
Brugia malayi hypothetical protein 0.0019 0.0136 0.0212
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0311 0.0639
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0022 0.0183 0.2072
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0193 0.2722 0.4183
Echinococcus granulosus calcium dependent protein kinase 0.0038 0.0423 0.0572
Toxoplasma gondii protein kinase, putative 0.0372 0.5382 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0031 0.032 0.5433
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Echinococcus granulosus beta LACTamase domain containing family member 0.003 0.0311 0.0397
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.012 0.0186
Plasmodium falciparum protein kinase 6 0.0559 0.8154 1
Schistosoma mansoni sex comb on midleg homolog 0.004 0.0458 0.1162
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Brugia malayi Bromodomain containing protein 0.0063 0.0799 0.1243
Giardia lamblia Prolyl-tRNA synthetase 0.004 0.0447 1
Toxoplasma gondii pyruvate kinase PyK1 0.0031 0.032 0.0455
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Trichomonas vaginalis pyruvate kinase, putative 0.0031 0.032 0.0667
Echinococcus granulosus Ankyrin 0.0029 0.0298 0.0376
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Trichomonas vaginalis glucose transporter, putative 0.0019 0.0136 0.0054
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.004 0.046 0.063
Trichomonas vaginalis CAMK family protein kinase 0.004 0.046 0.1133
Schistosoma mansoni hypothetical protein 0.0132 0.1815 0.5056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0039 0.0433 0.0588
Loa Loa (eye worm) hypothetical protein 0.004 0.046 0.063
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.004 0.046 0.0719
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0019 0.0136 0.1696
Brugia malayi Sugar transporter family protein 0.0019 0.0136 0.0212
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Schistosoma mansoni sugar transporter 0.0019 0.0136 0.0239
Brugia malayi beta-lactamase family protein 0.003 0.0311 0.0484
Schistosoma mansoni protein kinase 0.004 0.046 0.1167
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.004 0.0447 0.0696
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0183 0.0129
Trypanosoma cruzi pyruvate kinase 2, putative 0.0031 0.032 0.5433
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0046 0.0545 0.8664
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0029 0.0297 0.4149
Schistosoma mansoni hypothetical protein 0.0013 0.0058 0.0017
Plasmodium falciparum calcium-dependent protein kinase 3 0.004 0.046 0.0472
Plasmodium falciparum pyruvate kinase 0.0031 0.032 0.0299
Plasmodium vivax proline--tRNA ligase, putative 0.0046 0.0545 0.0577
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.004 0.0458 0.1078
Schistosoma mansoni hypothetical protein 0.0248 0.3539 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0136 0.0054
Leishmania major myo-inositol/proton symporter (MIT) 0.0019 0.0136 0.1469
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0311 0.0743
Schistosoma mansoni smad1 5 8 and 0.0014 0.0075 0.0064
Echinococcus granulosus histone lysine methyltransferase setb 0.0042 0.0485 0.0669
Onchocerca volvulus 0.0077 0.1004 0.291
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0074 0.0063
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0019 0.0136 0.0071
Brugia malayi Uncoordinated protein 44 0.0029 0.0296 0.0461
Echinococcus granulosus mothers against decapentaplegic 5 0.0014 0.0075 0.0026
Echinococcus granulosus nuclear factor of activated T cells 5 0.0287 0.4113 0.6366
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0077 0.1004 0.273
Trypanosoma brucei glucose transporter, putative 0.0041 0.0467 0.8428
Loa Loa (eye worm) hypothetical protein 0.0031 0.032 0.041
Brugia malayi Major Facilitator Superfamily protein 0.0019 0.0136 0.0212
Schistosoma mansoni hypothetical protein 0.0013 0.0058 0.0017
Schistosoma mansoni protein kinase 0.004 0.046 0.1167
Loa Loa (eye worm) hypothetical protein 0.003 0.0311 0.0397
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Schistosoma mansoni lysyl-tRNA synthetase 0.0029 0.0297 0.0702
Echinococcus granulosus neuropeptide receptor A26 0.039 0.5643 0.8769
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0213 0.3018 0.3641
Echinococcus multilocularis L aminoadipate semialdehyde 0.0077 0.1004 0.0951
Schistosoma mansoni hypothetical protein 0.0029 0.0296 0.0698
Schistosoma mansoni glucose transport protein 0.0132 0.1815 0.5056
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0257 0.0311
Plasmodium falciparum lysine--tRNA ligase 0.0029 0.0297 0.0271
Echinococcus granulosus solute carrier family 22 0.0019 0.0136 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0039 0.0433 0.0674
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0287 0.4113 0.4079
Echinococcus granulosus methyl CpG binding domain protein 2 0.0014 0.0074 0.0025
Trypanosoma cruzi hexose transporter, putative 0.0022 0.0192 0.2844
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0311 0.5262
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Echinococcus multilocularis beta LACTamase domain containing family member 0.003 0.0311 0.0254
Echinococcus granulosus pyruvate kinase 0.0031 0.032 0.041
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0132 0.1815 0.2758
Brugia malayi PHD-finger family protein 0.0021 0.0173 0.0269
Trypanosoma brucei sugar transporter, putative 0.0019 0.0136 0.1696
Echinococcus granulosus solute carrier family 22 0.0019 0.0136 0.0122
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.004 0.0447 0.0696
Mycobacterium ulcerans esterase/lipase LipP 0.003 0.0311 0.4403
Toxoplasma gondii exonuclease III APE 0.0017 0.012 0.0078
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.004 0.046 0.8272
Schistosoma mansoni ap endonuclease 0.0017 0.012 0.0193
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0025 0.0232 0.0576
Loa Loa (eye worm) pyruvate kinase 0.0031 0.032 0.041
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.003 0.0311 0.0484
Schistosoma mansoni myelin transcription factor 1 myt1 0.0046 0.054 0.1399
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0019 0.0136 0.0216
Schistosoma mansoni smad1 5 8 and 0.0014 0.0075 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Echinococcus multilocularis solute carrier family 22 0.0019 0.0136 0.0078
Brugia malayi isocitrate dehydrogenase 0.0015 0.0078 0.0122
Trypanosoma brucei glucose transporter 2A 0.0041 0.0467 0.8428
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0078 0.0456
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.062 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0485 0.0754
Mycobacterium tuberculosis Probable lipase LipD 0.003 0.0311 0.0876
Plasmodium vivax calcium-dependent protein kinase, putative 0.004 0.046 0.0472
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.003 0.0311 0.4403
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0042 0.0485 0.0429
Brugia malayi MH2 domain containing protein 0.0014 0.0075 0.0116
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0311 0.0639
Loa Loa (eye worm) transcription factor SMAD2 0.0211 0.2995 0.4611
Plasmodium falciparum mitogen-activated protein kinase 2 0.0213 0.3018 0.3641
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0272 0.0364
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Trypanosoma cruzi sugar transporter, putative 0.0019 0.0136 0.1696
Leishmania major glucose transporter, lmgt3 0.0041 0.0467 0.7302
Trypanosoma brucei THT1 - hexose transporter, putative 0.0041 0.0467 0.8428
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0014 0.0074 0.0016
Schistosoma mansoni protein kinase 0.004 0.046 0.1167
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0467 0.1159
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Loa Loa (eye worm) hypothetical protein 0.0032 0.0337 0.0438
Onchocerca volvulus Huntingtin homolog 0.0114 0.1545 0.4724
Trypanosoma brucei glucose transporter, putative 0.0041 0.0467 0.8428
Schistosoma mansoni hypothetical protein 0.0029 0.0287 0.0673
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.004 0.046 0.0472
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0014 0.0075 0.0016
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0132 0.1815 0.1767
Toxoplasma gondii ABC1 family protein 0.003 0.0311 0.0439
Brugia malayi Protein kinase domain containing protein 0.0032 0.0333 0.0519
Loa Loa (eye worm) hypothetical protein 0.0029 0.0287 0.0359
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0078 0.002
Loa Loa (eye worm) beta-lactamase 0.003 0.0311 0.0397
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.012 0.0096
Trichomonas vaginalis glucose transporter, putative 0.0041 0.0467 0.1159
Onchocerca volvulus 0.003 0.0311 0.0588
Entamoeba histolytica hypothetical protein 0.0029 0.0297 0.5227
Brugia malayi beta-lactamase family protein 0.003 0.0311 0.0484
Loa Loa (eye worm) major facilitator superfamily transporter 0.0019 0.0136 0.0122
Schistosoma mansoni pyruvate kinase 0.0031 0.032 0.0767
Onchocerca volvulus 0.003 0.0311 0.0588
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.012 0.1367
Echinococcus granulosus Sugar transporter ERD6 protein 0.0019 0.0136 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Loa Loa (eye worm) hypothetical protein 0.003 0.0311 0.0397
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.012 0.0156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0433 0.0588
Trypanosoma brucei glucose transporter, putative 0.0041 0.0467 0.8428
Echinococcus multilocularis mothers against decapentaplegic 5 0.0014 0.0075 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0433 0.0377
Schistosoma mansoni survival motor neuron protein 0.009 0.1201 0.3293
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.046 0.0403
Mycobacterium ulcerans pyruvate kinase 0.0031 0.032 0.4556
Loa Loa (eye worm) hypothetical protein 0.004 0.0447 0.0611
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.004 0.046 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0136 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Loa Loa (eye worm) hypothetical protein 0.0029 0.0297 0.0375
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0042 0.0485 0.124
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0058 0.0091
Brugia malayi MH1 domain containing protein 0.0014 0.0075 0.0116
Echinococcus multilocularis Smad4 0.0014 0.0075 0.0016
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0046 0.054 0.0756
Echinococcus granulosus pyruvate kinase 0.0016 0.0097 0.006
Onchocerca volvulus Pyruvate kinase homolog 0.0031 0.032 0.0616
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0132 0.1815 0.1767
Onchocerca volvulus Netrin receptor homolog 0.0029 0.0296 0.0537
Brugia malayi Sugar transporter family protein 0.0019 0.0136 0.0212
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.0031
Brugia malayi Major Facilitator Superfamily protein 0.0019 0.0136 0.0212
Brugia malayi hypothetical protein 0.0019 0.0136 0.0212
Schistosoma mansoni hypothetical protein 0.0017 0.0119 0.0191
Echinococcus multilocularis pyruvate kinase 0.0016 0.0097 0.0038
Echinococcus multilocularis solute carrier family 22 0.0019 0.0136 0.0078
Echinococcus granulosus synaptic vesicle 2 protein 0.0019 0.0136 0.0122
Leishmania major glucose transporter, lmgt2 0.0041 0.0467 0.7302
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0467 0.1159
Toxoplasma gondii lysine-tRNA ligase 0.0029 0.0297 0.0413
Echinococcus granulosus fetal alzheimer antigen falz 0.0019 0.0143 0.0133
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0485 0.0669
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.004 0.0458 0.1162
Echinococcus granulosus zinc finger protein 0.0016 0.0106 0.0075
Trypanosoma brucei glucose transporter, putative 0.0041 0.0467 0.8428
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.004 0.0447 0.1133
Echinococcus multilocularis solute carrier family 22 0.0019 0.0136 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Loa Loa (eye worm) hypothetical protein 0.0046 0.054 0.0756
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.012 0.1367
Echinococcus granulosus TGF beta signal transducer SmadC 0.0014 0.0075 0.0026
Mycobacterium leprae Probable lipase LipE 0.003 0.0311 0.4862
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.004 0.0447 0.0611
Loa Loa (eye worm) pyruvate kinase-PB 0.0022 0.0181 0.0193
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.012 0.0932
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0074 0.0063
Leishmania major lysyl-tRNA synthetase, putative 0.0029 0.0297 0.4311
Loa Loa (eye worm) hypothetical protein 0.0443 0.6427 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.004 0.046 0.0472
Schistosoma mansoni glucose transporter 0.0019 0.0136 0.0239
Mycobacterium tuberculosis Probable hydrolase 0.003 0.0311 0.0876
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0078 0.0527
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0058 0.0091
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0132 0.1815 0.2758
Mycobacterium ulcerans integral membrane transport protein 0.0019 0.0136 0.1226
Echinococcus multilocularis smad 0.0014 0.0075 0.0016
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.004 0.046 0.0472
Brugia malayi Pre-SET motif family protein 0.0193 0.2722 0.4236
Echinococcus granulosus SAM and MBT domain containing protein 0.004 0.0458 0.0627
Echinococcus granulosus pyruvate kinase 0.0016 0.0097 0.006
Echinococcus granulosus death domain containing protein 0.0029 0.0296 0.0373
Mycobacterium tuberculosis Probable lipase LipE 0.003 0.0311 0.0876
Schistosoma mansoni hypothetical protein 0.0143 0.198 0.5528
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.062 0.1629
Trypanosoma brucei pyruvate kinase 1 0.0031 0.032 0.5433
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0136 0.1696
Brugia malayi MH2 domain containing protein 0.0211 0.2995 0.466
Echinococcus multilocularis polycomb protein SCMH1 0.004 0.0458 0.0402
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0019 0.0136 0.0239
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0467 0.1159
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.004 0.0447 0.1093
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.003 0.0311 0.0876
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.0075 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Loa Loa (eye worm) MBCTL1 0.0046 0.054 0.0756
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0078 0.0031
Echinococcus multilocularis pyruvate kinase 0.0031 0.032 0.0263
Trypanosoma cruzi hexose transporter 0.0041 0.0467 0.8428
Echinococcus multilocularis pyruvate kinase 0.0016 0.0097 0.0038
Mycobacterium tuberculosis Conserved protein 0.003 0.0311 0.0876
Schistosoma mansoni ap endonuclease 0.0017 0.012 0.0193
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0132 0.1815 0.2758
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0296 0.0461
Trypanosoma cruzi hexose transporter, putative 0.0041 0.0467 0.8428
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0019 0.0136 0.1226
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Trichomonas vaginalis sugar transport protein, putative 0.0019 0.0136 0.0054
Giardia lamblia Pyruvate kinase 0.0031 0.032 0.6363
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0272 0.0628
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.004 0.046 0.0403
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0213 0.3018 0.5544
Loa Loa (eye worm) hypothetical protein 0.003 0.0311 0.0397
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0046 0.0545 0.0879
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0132 0.1815 0.1767
Plasmodium vivax SET domain protein, putative 0.0028 0.0272 0.0239
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0029 0.0297 0.4331
Loa Loa (eye worm) bromodomain containing protein 0.0015 0.0082 0.0037
Brugia malayi lysyl-tRNA synthetase 0.0029 0.0297 0.0463
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0029 0.0297 0.4976
Loa Loa (eye worm) hypothetical protein 0.004 0.0458 0.0627
Leishmania major hypothetical protein, conserved 0.0019 0.0136 0.1469
Schistosoma mansoni hypothetical protein 0.009 0.1201 0.3293
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Mycobacterium tuberculosis Probable esterase LipL 0.003 0.0311 0.0876
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.005 0.0608 0.0552
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0046 0.0545 1
Echinococcus multilocularis survival motor neuron protein 1 0.0443 0.6427 0.6406
Echinococcus multilocularis pyruvate kinase 0.0031 0.032 0.0263
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.002
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0022 0.0183 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0019 0.0143 0.026
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0272 0.0214
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.0183 0.2292
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0433 0.1092
Loa Loa (eye worm) mbt repeat family protein 0.004 0.0458 0.0627
Brugia malayi major facilitator superfamily protein 0.0019 0.0136 0.0212
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Brugia malayi MH2 domain containing protein 0.0014 0.0075 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Loa Loa (eye worm) hypothetical protein 0.0042 0.0485 0.0669
Plasmodium falciparum protein kinase 7 0.0372 0.5382 0.6567
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Brugia malayi Bromodomain containing protein 0.0032 0.034 0.0529
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0311 0.0639
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Echinococcus granulosus General substrate transporter 0.0113 0.154 0.2327
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Onchocerca volvulus Pyruvate kinase homolog 0.0031 0.032 0.0616
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.012 0.066
Trichomonas vaginalis pyruvate kinase, putative 0.0031 0.032 0.0667
Loa Loa (eye worm) hypothetical protein 0.0032 0.0341 0.0444
Schistosoma mansoni hypothetical protein 0.0143 0.198 0.5528
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0078 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0467 0.1159
Giardia lamblia Hexose transporter 0.0019 0.0136 0.1122
Toxoplasma gondii sugar transporter ST3 0.0019 0.0136 0.0108
Schistosoma mansoni Smad4 0.0014 0.0075 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0433 0.0588
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0029 0.0297 0.0592
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0019 0.0143 0.0085
Trypanosoma brucei THT1 - hexose transporter, putative 0.0041 0.0467 0.8428
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0046 0.0545 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0025 0.0232 0.1848
Trypanosoma brucei glucose transporter, putative 0.0041 0.0467 0.8428
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0433 0.0377
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0019 0.0136 0.0216
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0183 0.2646
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Onchocerca volvulus Huntingtin homolog 0.0114 0.1545 0.4724
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0296 0.0373
Brugia malayi Smad1 0.0014 0.0075 0.0116
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.003 0.0311 0.0876
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.009 0.1201 0.1868
Echinococcus multilocularis SAM and MBT domain containing protein 0.004 0.0458 0.0402
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0162 0.2264 0.2218
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.003 0.0311 0.0397
Echinococcus multilocularis histone acetyltransferase MYST2 0.0046 0.054 0.0485
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.004 0.046 0.0715
Plasmodium falciparum proline--tRNA ligase 0.0046 0.0545 0.0577
Mycobacterium tuberculosis Conserved protein 0.003 0.0311 0.0876
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0162 0.2264 0.3462
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0046 0.054 0.0485
Leishmania major glucose transporter/membrane transporter D2, putative 0.0041 0.0467 0.7302
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0136 0.0054
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.012 0.0051
Plasmodium vivax pyruvate kinase, putative 0.0031 0.032 0.0299
Loa Loa (eye worm) hypothetical protein 0.006 0.0745 0.1079
Plasmodium falciparum calcium-dependent protein kinase 5 0.004 0.046 0.0472
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0467 0.1159
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.012 0.1184
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0019 0.0136 0.2573
Echinococcus multilocularis pyruvate kinase 0.0016 0.0097 0.0038
Toxoplasma gondii transporter, major facilitator family protein 0.0019 0.0136 0.0108
Echinococcus granulosus smad 0.0014 0.0075 0.0026
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.046 0.063
Echinococcus granulosus solute carrier family 22 0.0019 0.0136 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Schistosoma mansoni hypothetical protein 0.0013 0.0058 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.062 0.1629
Schistosoma mansoni pyruvate kinase 0.0031 0.032 0.0767
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.046 0.063
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0078 0.0074
Leishmania major pyruvate kinase 0.0031 0.032 0.4707
Schistosoma mansoni pyruvate kinase 0.0016 0.0097 0.0126
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0051 0.062 0.0565
Brugia malayi mbt repeat family protein 0.004 0.0458 0.0712
Mycobacterium ulcerans lipase LipD 0.003 0.0311 0.4403
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1815 0.5655
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0022 0.0183 0.0197
Brugia malayi beta-lactamase 0.003 0.0311 0.0484
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0132 0.1815 0.1767
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Brugia malayi hypothetical protein 0.0114 0.1545 0.2404
Schistosoma mansoni glucose transport protein 0.0132 0.1815 0.5056
Echinococcus granulosus neuropeptide s receptor 0.039 0.5643 0.8769
Plasmodium vivax CDK-related protein kinase 6, putative 0.0559 0.8154 1
Echinococcus multilocularis calcium dependent protein kinase 0.0038 0.0423 0.0366
Echinococcus multilocularis netrin receptor unc 5 0.0029 0.0296 0.0239
Trypanosoma brucei THT1 - hexose transporter, putative 0.0041 0.0467 0.8428
Brugia malayi major facilitator superfamily protein 0.0019 0.0136 0.0212
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0077 0.1004 0.1562
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.004 0.0447 0.0391
Plasmodium vivax lysine--tRNA ligase, putative 0.0029 0.0297 0.0271
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.012 0.0096
Schistosoma mansoni smad1 5 8 and 0.0014 0.0075 0.0064
Trypanosoma cruzi pyruvate kinase 2, putative 0.0031 0.032 0.5433
Onchocerca volvulus 0.004 0.0458 0.1078
Echinococcus granulosus solute carrier family 22 0.0019 0.0136 0.0122
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0022 0.0183 0.4548
Echinococcus multilocularis geminin 0.0143 0.198 0.1933
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0244 0.0413
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0046 0.0545 0.8664
Loa Loa (eye worm) MH2 domain-containing protein 0.0211 0.2995 0.4611
Schistosoma mansoni bromodomain containing protein 0.0053 0.0652 0.1721
Brugia malayi Death domain containing protein 0.0029 0.0296 0.0461
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0485 0.0754
Echinococcus granulosus histone acetyltransferase MYST2 0.0046 0.054 0.0756
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0029 0.0297 0.4976
Brugia malayi hypothetical protein 0.0019 0.0136 0.0212
Echinococcus granulosus geminin 0.0143 0.198 0.3017
Loa Loa (eye worm) hypothetical protein 0.0077 0.1004 0.1485
Schistosoma mansoni sugar transporter 0.0019 0.0136 0.0239
Trypanosoma brucei glucose transporter, putative 0.0041 0.0467 0.8428
Mycobacterium tuberculosis Conserved protein 0.003 0.0311 0.0876
Echinococcus multilocularis zinc finger protein 0.0016 0.0106 0.0048
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0022 0.0183 0.2072
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0183 0.0129
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.012 0.1367
Plasmodium falciparum hexose transporter 0.0132 0.1815 0.2151
Echinococcus multilocularis neuropeptide receptor A26 0.039 0.5643 0.5617
Trypanosoma brucei glucose transporter, putative 0.0041 0.0467 0.8428
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.004 0.046 0.063
Plasmodium vivax hexose transporter 0.0132 0.1815 0.2151
Echinococcus multilocularis Ankyrin 0.0029 0.0298 0.0241
Giardia lamblia Lysyl-tRNA synthetase 0.0029 0.0297 0.5722
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0029 0.0296 0.0239
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0029 0.0297 0.4149
Mycobacterium leprae Probable pyruvate kinase PykA 0.0031 0.032 0.518
Schistosoma mansoni sugar transporter 0.0019 0.0136 0.0239
Brugia malayi Cam kinase protein 1 0.004 0.046 0.0715
Mycobacterium leprae conserved hypothetical protein 0.003 0.0311 0.4862
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.005 0.0608 0.0862
Brugia malayi Pyruvate kinase, M2 isozyme 0.0031 0.032 0.0498
Plasmodium vivax hypothetical protein, conserved 0.003 0.0311 0.0288
Loa Loa (eye worm) hypothetical protein 0.004 0.0447 0.0611
Onchocerca volvulus 0.0028 0.0272 0.0455
Entamoeba histolytica protein kinase, putative 0.004 0.046 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0019 0.0136 0.0122
Loa Loa (eye worm) hypothetical protein 0.0114 0.1545 0.2335
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0194 0.2737 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0022 0.0183 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.012 0.45
Loa Loa (eye worm) hypothetical protein 0.003 0.0311 0.0397
Echinococcus multilocularis General substrate transporter 0.0113 0.154 0.1491
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Chlamydia trachomatis pyruvate kinase 0.0031 0.032 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.004 0.046 0.0719
Onchocerca volvulus 0.003 0.0311 0.0588
Loa Loa (eye worm) hypothetical protein 0.0114 0.1545 0.2335
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0311 0.5262
Plasmodium falciparum calcium-dependent protein kinase 1 0.004 0.046 0.0472
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.002
Schistosoma mansoni smad 0.0014 0.0075 0.0064
Schistosoma mansoni lysyl-tRNA synthetase 0.0029 0.0297 0.0702
Trypanosoma cruzi hexose transporter, putative 0.0041 0.0467 0.8428
Trichomonas vaginalis glucose transporter, putative 0.0041 0.0467 0.1159
Toxoplasma gondii pyruvate kinase PyKII 0.0016 0.0097 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0136 0.0122
Schistosoma mansoni netrin receptor unc5 0.0029 0.0296 0.0698
Brugia malayi Sugar transporter family protein 0.0132 0.1815 0.2824
Onchocerca volvulus Pyruvate kinase homolog 0.0031 0.032 0.0616
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.004 0.0447 1
Schistosoma mansoni glucose transport protein 0.0132 0.1815 0.5056
Loa Loa (eye worm) hypothetical protein 0.003 0.0311 0.0397
Echinococcus multilocularis lysyl tRNA synthetase 0.0029 0.0297 0.024
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0051 0.062 0.0882
Trypanosoma brucei glucose transporter, putative 0.0041 0.0467 0.8428
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0433 0.1092
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.012 0.0062
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.012 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0296 0.0373
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Trichomonas vaginalis set domain proteins, putative 0.0219 0.3118 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.062 1
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Entamoeba histolytica protein kinase, putative 0.004 0.046 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.004 0.0447 0.1133
Mycobacterium ulcerans hypothetical protein 0.003 0.0311 0.4403
Echinococcus granulosus polycomb protein SCMH1 0.004 0.0458 0.0627
Echinococcus granulosus lysyl tRNA synthetase 0.0029 0.0297 0.0375
Echinococcus granulosus L aminoadipate semialdehyde 0.0077 0.1004 0.1485
Leishmania major hypothetical protein, conserved 0.003 0.0311 0.4559
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0311 0.0743
Loa Loa (eye worm) hypothetical protein 0.0042 0.0485 0.0669
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0433 0.1092
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.002
Loa Loa (eye worm) pyruvate kinase 0.0031 0.032 0.041
Schistosoma mansoni zinc finger protein 0.0016 0.0106 0.0153
Brugia malayi MH1 domain containing protein 0.0014 0.0075 0.0116
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0019 0.0136 0.0078
Brugia malayi Pyruvate kinase, muscle isozyme 0.0031 0.032 0.0498
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.031 0.0396
Trypanosoma cruzi glucose transporter, putative 0.0019 0.0136 0.1696
Echinococcus granulosus netrin receptor unc 5 0.0029 0.0296 0.0373
Schistosoma mansoni ankyrin 23/unc44 0.0029 0.0296 0.0698
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0119 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0136 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0019 0.0136 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0042 0.0485 0.124
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.003 0.0311 0.0876
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0078 0.002
Brugia malayi mbt repeat family protein 0.004 0.0458 0.0712

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 8.3 uM Cytotoxicity against human PC3 cells after 72 hrs by Alamar blue assay ChEMBL. 23360284

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23360284

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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