Detailed information for compound 1772137

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 333.43 | Formula: C20H23N5
  • H donors: 2 H acceptors: 2 LogP: 3.14 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)NCc1ccnc2c1nccc2c1ccc(cc1)C(C)(C)C
  • InChi: 1S/C20H23N5/c1-20(2,3)15-6-4-13(5-7-15)16-9-11-23-17-14(12-25-19(21)22)8-10-24-18(16)17/h4-11H,12H2,1-3H3,(H4,21,22,25)
  • InChiKey: BQAPBOBYFZVYEJ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0062 0.0101
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Schistosoma mansoni chromobox protein 0.0072 0.0129 0.0209
Echinococcus multilocularis Squalene phytoene synthase 0.0331 0.0717 0.1164
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Brugia malayi Cation transporter family protein 0.0194 0.0406 0.0406
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0224 0.0473 0.0768
Loa Loa (eye worm) hypothetical protein 0.0065 0.0114 0.0114
Onchocerca volvulus 0.0042 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus multilocularis glycine receptor subunit beta 0.0121 0.0241 0.0391
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0043 0.0063 0.0062
Schistosoma mansoni opsin-like receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) zinc finger protein 0.0303 0.0653 0.0653
Mycobacterium tuberculosis Probable reductase 0.0085 0.0158 0.219
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Schistosoma mansoni neuropeptide receptor 0.0042 0.0062 0.0101
Echinococcus granulosus probable protein arginine n-methyltransferase 0.0286 0.0615 0.0998
Schistosoma mansoni neuropeptide receptor 0.0042 0.0062 0.0101
Echinococcus granulosus sodium and chloride dependent glycine 0.0224 0.0473 0.0768
Brugia malayi Bromodomain containing protein 0.003 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0235 0.0498 0.0498
Echinococcus multilocularis Smad4 0.0016 0.0002 0.0004
Onchocerca volvulus Putative nachr subunit 0.0191 0.04 0.1325
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0062 0.0101
Schistosoma mansoni acetylcholine receptor-related 0.0056 0.0093 0.0151
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0158 0.219
Loa Loa (eye worm) hypothetical protein 0.0065 0.0114 0.0114
Brugia malayi Muscleblind-like protein 0.0148 0.0302 0.0302
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.0496 0.0496
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0224 0.0473 0.0768
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0592 0.1308 1
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Echinococcus multilocularis RUN 0.0019 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0108 0.0689
Schistosoma mansoni cpg binding protein 0.0059 0.0101 0.0163
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0224 0.0473 0.0768
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) RNA binding protein 0.0062 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0046
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0062 0.0062
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0062 0.0101
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0062 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0106 0.0172
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Brugia malayi Heterochromatin protein 1 0.0072 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Schistosoma mansoni cpg binding protein 0.0059 0.0101 0.0163
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0062 0.0062
Plasmodium falciparum amino acid transporter, putative 0.0224 0.0473 1
Toxoplasma gondii hypothetical protein 0.0224 0.0473 0.3046
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0063 0.0436
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0074 0.0134 0.0218
Brugia malayi MH2 domain containing protein 0.0016 0.0002 0.0002
Onchocerca volvulus 0.0042 0.0062 0.0178
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0219 0.0462 0.0462
Echinococcus granulosus sex peptide receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0065 0.0114 0.0114
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Schistosoma mansoni neuropeptide receptor 0.0042 0.0062 0.0101
Trypanosoma brucei squalene synthase, putative 0.1063 0.2377 0.2376
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0011 0.0017
Echinococcus multilocularis glycine receptor subunit beta 0.0121 0.0241 0.0391
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0046 0.0046
Schistosoma mansoni neurotransmitter gated ion channel 0.0056 0.0093 0.0151
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0123 0.0245 0.1097
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0121 0.0241 0.0391
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus chromobox protein 1 0.0072 0.0129 0.0209
Echinococcus multilocularis vesicular acetylcholine transporter 0.0219 0.0462 0.0749
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0063 0.0436
Schistosoma mansoni hypothetical protein 0.0331 0.0717 0.1164
Toxoplasma gondii thioredoxin reductase 0.0037 0.005 0.0318
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0106 0.0172
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0699 0.1551 1
Echinococcus multilocularis muscleblind protein 0.0148 0.0302 0.049
Loa Loa (eye worm) hypothetical protein 0.0224 0.0473 0.0473
Brugia malayi ORL1-like opioid receptor 0.0042 0.0062 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0073 0.0118
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0062 0.0101
Brugia malayi Pre-SET motif family protein 0.0062 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0108 0.0175
Schistosoma mansoni protein arginine n-methyltransferase 0.0043 0.0063 0.0102
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0498 0.0808
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0062 0.0101
Loa Loa (eye worm) norepinephrine transporter 0.1317 0.2952 0.2952
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0474 0.6603
Loa Loa (eye worm) hypothetical protein 0.0123 0.0245 0.0245
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0062 0.0101
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0046
Echinococcus granulosus g protein coupled receptor 0.0042 0.0062 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0062 0.0101
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0062 0.0101
Echinococcus multilocularis chromobox protein 1 0.0072 0.0129 0.0209
Echinococcus multilocularis smad 0.0016 0.0002 0.0004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0224 0.0473 0.0768
Schistosoma mansoni amine GPCR 0.0042 0.0062 0.0101
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0289 0.0621 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0022 0.0119
Schistosoma mansoni nAChR subunit 0.0056 0.0093 0.0151
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0123 0.0245 0.0244
Onchocerca volvulus 0.0194 0.0406 0.1346
Mycobacterium tuberculosis Conserved protein 0.0035 0.0046 0.0624
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0061 0.0099
Brugia malayi Cytochrome P450 family protein 0.0029 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Leishmania major arginine N-methyltransferase, type I 0.0093 0.0178 0.0177
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0121 0.0241 0.0391
Echinococcus granulosus glycine receptor subunit alpha 1 0.0121 0.0241 0.0391
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0062 0.0062
Brugia malayi Doublecortin family protein 0.0019 0.001 0.001
Mycobacterium tuberculosis Putative methyltransferase 0.0043 0.0063 0.0864
Schistosoma mansoni biogenic amine receptor 0.0042 0.0062 0.0101
Onchocerca volvulus 0.0042 0.0062 0.0178
Onchocerca volvulus 0.0042 0.0062 0.0178
Mycobacterium ulcerans beta-lactamase 0.0035 0.0046 0.0475
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0129 0.0129
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0016
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0121 0.0241 0.0241
Plasmodium falciparum glutathione reductase 0.0037 0.005 0.1044
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0093 0.0178 0.1319
Schistosoma mansoni nAChR subunit 0.0056 0.0093 0.0151
Echinococcus granulosus tar DNA binding protein 0.0062 0.0106 0.0172
Loa Loa (eye worm) hypothetical protein 0.0224 0.0473 0.0473
Plasmodium falciparum phd finger protein, putative 0.003 0.0034 0.0704
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0212 0.1364
Echinococcus multilocularis allatostatin A receptor 0.0042 0.0062 0.0101
Trichomonas vaginalis esterase, putative 0.0035 0.0046 0.0304
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0555 0.1224 0.1986
Brugia malayi larval opioid receptor 0.0042 0.0062 0.0062
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0046 0.0624
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0224 0.0473 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0179 0.2488
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0331 0.0717 0.2405
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0121 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Mycobacterium leprae Hypothetical protein 0.0043 0.0063 0.0298
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0062 0.0101
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0025 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0224 0.0473 1
Schistosoma mansoni hypothetical protein 0.003 0.0034 0.0055
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0121 0.0241 0.0391
Echinococcus granulosus glycine receptor subunit alpha 1 0.0121 0.0241 0.0391
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0022 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0022 0.0119
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0062 0.0101
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.005 0.1044
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.006 0.0097
Schistosoma mansoni hypothetical protein 0.0078 0.0143 0.0233
Onchocerca volvulus 0.0056 0.0093 0.0283
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Loa Loa (eye worm) serotonin transporter b 0.1317 0.2952 0.2952
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Schistosoma mansoni smad1 5 8 and 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Brugia malayi MH1 domain containing protein 0.0016 0.0002 0.0002
Echinococcus granulosus nAChR subunit 0.0065 0.0114 0.0186
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0002 0.0002
Onchocerca volvulus 0.0056 0.0093 0.0284
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0062 0.0101
Onchocerca volvulus 0.0121 0.0241 0.0787
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0241 0.0391
Brugia malayi Smad1 0.0016 0.0002 0.0002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0062 0.0101
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0093 0.0178 0.0289
Schistosoma mansoni histamine h1 receptor 0.0042 0.0062 0.0101
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0003 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.1308 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0121 0.0241 0.0241
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0121 0.0241 0.0241
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Schistosoma mansoni rab6-interacting 0.0019 0.001 0.0016
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0062 0.0101
Onchocerca volvulus 0.0042 0.0062 0.0178
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0106 0.0172
Brugia malayi beta-lactamase 0.0035 0.0046 0.0046
Mycobacterium ulcerans methyltransferase 0.0043 0.0063 0.0718
Leishmania major arginine N-methyltransferase-like protein 0.003 0.0034 0.0033
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Brugia malayi hypothetical protein 0.0056 0.0093 0.0093
Trypanosoma cruzi C-8 sterol isomerase, putative 0.4425 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0062 0.0101
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0072 0.013 0.0954
Schistosoma mansoni nAChR subunit 0.0121 0.0241 0.0391
Mycobacterium leprae PROBABLE PROTOPORHYRINOGEN OXIDASE HEMK HOMOLOG 0.0043 0.0063 0.0298
Mycobacterium ulcerans methyltransferase 0.0043 0.0063 0.0718
Loa Loa (eye worm) acetylcholine receptor protein 0.0056 0.0093 0.0093
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0179 0.232
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0062 0.0062
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0046 0.0624
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0031 0.0189
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0062 0.0101
Onchocerca volvulus 0.0042 0.0062 0.0178
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0224 0.0473 0.3046
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0289 0.0621 0.8639
Loa Loa (eye worm) hypothetical protein 0.2262 0.5095 0.5095
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0121 0.0241 0.0391
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0108 0.0175
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0067 0.0117 0.0191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0108 0.0175
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Schistosoma mansoni smad1 5 8 and 0.0016 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.1036 0.2315 0.3757
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0247 0.0526 0.0526
Loa Loa (eye worm) GABA receptor subunit 0.0065 0.0114 0.0114
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.0496 0.0496
Echinococcus granulosus dnaJ subfamily B 0.0799 0.1778 0.2886
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0062 0.0101
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0073 0.0118
Mycobacterium tuberculosis Conserved protein 0.0043 0.0063 0.0864
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0194 0.0406 0.0658
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0072 0.013 0.0834
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0224 0.0473 0.0768
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0121 0.0241 0.0241
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0224 0.0473 0.0768
Echinococcus granulosus RUN 0.0019 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0062 0.0101
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.0062 0.0101
Schistosoma mansoni hypothetical protein 0.0042 0.0062 0.0101
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0224 0.0473 0.0768
Echinococcus granulosus nmda type glutamate receptor 0.0028 0.003 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.1308 1
Brugia malayi SET domain containing protein 0.0015 0.0001 0.0001
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0002 0.0004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0046 0.0074
Brugia malayi Dopamine receptor protein 1 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Brugia malayi Cation transporter family protein 0.0121 0.0241 0.0241
Loa Loa (eye worm) Smad1 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0169 0.0349 0.0349
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.0062 0.0178
Brugia malayi Carm1-pending protein 0.0699 0.1551 0.1551
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0062 0.0101
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0072 0.013 0.0211
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Brugia malayi Melatonin receptor type 1A 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0046
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0121 0.0241 0.0241
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.1308 1
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0062 0.0101
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0056 0.0093 0.0151
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0001
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0224 0.0473 0.0768
Schistosoma mansoni vesicular acetylcholine transporter 0.0219 0.0462 0.0749
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0057 0.0393
Brugia malayi Zinc finger, C2H2 type family protein 0.0303 0.0653 0.0653
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.4425 1 1
Echinococcus granulosus muscleblind protein 0.0148 0.0302 0.049
Loa Loa (eye worm) hypothetical protein 0.0051 0.0083 0.0083
Echinococcus granulosus synaptic vesicular amine transporter 0.2733 0.6162 1
Onchocerca volvulus 0.0035 0.0046 0.0122
Echinococcus multilocularis protein arginine methyltransferase 0.0072 0.013 0.0211
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0056 0.0093 0.0093
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0123 0.0245 0.0244
Mycobacterium tuberculosis Possible transferase 0.0043 0.0063 0.0864
Echinococcus granulosus glutamate NMDA receptor subunit 0.0067 0.0117 0.0191
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0046 0.0046
Onchocerca volvulus 0.0056 0.0093 0.0283
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0158 0.219
Brugia malayi isocitrate dehydrogenase 0.0015 0.0001 0.0001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0592 0.1308 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0056 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0194 0.0406 0.0406
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0121 0.0241 0.0241
Schistosoma mansoni myosin xvIII 0.0042 0.0062 0.0101
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0062 0.0101
Echinococcus granulosus Smad4 0.0016 0.0002 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0062 0.0101
Echinococcus multilocularis synaptic vesicular amine transporter 0.2733 0.6162 1
Schistosoma mansoni hypothetical protein 0.0042 0.0062 0.0101
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0267 0.0571 0.0571
Echinococcus multilocularis serotonin receptor 0.0042 0.0062 0.0101
Brugia malayi Abnormal catecholamine distribution protein 1 0.2733 0.6162 0.6162
Schistosoma mansoni neuropeptide receptor 0.0042 0.0062 0.0101
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0224 0.0473 0.0768
Schistosoma mansoni hypothetical protein 0.0078 0.0143 0.0233
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0056 0.0093 0.0151
Brugia malayi PHD-finger family protein 0.003 0.0034 0.0034
Plasmodium vivax glutathione reductase, putative 0.0037 0.005 0.1044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.1308 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0075 0.0121
Loa Loa (eye worm) hypothetical protein 0.0191 0.04 0.04
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0046 0.0624
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0065 0.0114 0.0114
Schistosoma mansoni opsin-like receptor 0.0042 0.0062 0.0101
Brugia malayi hypothetical protein 0.0056 0.0093 0.0093
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.1809 0.2936
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0062 0.0101
Plasmodium vivax SET domain protein, putative 0.0062 0.0108 0.2262
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0062 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0108 0.0175
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0093 0.0093
Brugia malayi neuropeptide F receptor 0.0042 0.0062 0.0062
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0699 0.1551 0.2517
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.2733 0.6162 0.6162
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0224 0.0473 0.0473
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0129 0.0942
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0022 0.0119
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.0062 0.0178
Schistosoma mansoni smad1 5 8 and 0.0016 0.0002 0.0004
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0224 0.0473 0.0473
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0107 0.0107
Echinococcus granulosus protein arginine methyltransferase 0.0072 0.013 0.0211
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0093 0.0178 0.0177
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0121 0.0241 0.0241
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0191 0.04 0.04
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1317 0.2952 0.2952
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0062 0.0062
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0224 0.0473 0.3046
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0046 0.0307
Loa Loa (eye worm) hypothetical protein 0.0065 0.0114 0.0114
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0056 0.0093 0.0093
Mycobacterium ulcerans methylase 0.0043 0.0063 0.0718
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0062 0.0101
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0121 0.0241 0.0391
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0046 0.0475
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0052 0.0084
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0129 0.0942
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.0062 0.0101
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Onchocerca volvulus 0.0065 0.0114 0.0355
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0062 0.0101
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0106 0.0106
Brugia malayi Serotonin receptor 0.0042 0.0062 0.0062
Brugia malayi MH2 domain containing protein 0.0016 0.0002 0.0002
Schistosoma mansoni amine GPCR 0.0042 0.0062 0.0101
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0034 0.0211
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0051 0.0083
Brugia malayi RE15519p 0.0042 0.0062 0.0062
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0062 0.0101
Echinococcus multilocularis serotonin receptor 0.0042 0.0062 0.0101
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0062 0.0101
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0158 0.219
Mycobacterium ulcerans methyltransferase/methylase 0.0043 0.0063 0.0718
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0062 0.0062
Brugia malayi AKH receptor 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0046
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0121 0.0241 0.0391
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0062 0.0101
Brugia malayi Serotonin receptor 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Trypanosoma cruzi phytoene synthase, putative 0.0331 0.0717 0.0717
Leishmania major hypothetical protein, conserved 0.0043 0.0063 0.0062
Leishmania major hypothetical protein, conserved 0.0035 0.0046 0.0045
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0056 0.009
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0034 0.0034
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0034 0.0055
Brugia malayi glutathione reductase 0.0037 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Schistosoma mansoni cpg binding protein 0.0056 0.0093 0.0152
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0106 0.0172
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0073 0.0118
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0121 0.0241 0.0391
Leishmania major hypothetical protein, conserved 0.0331 0.0717 0.0717
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0046 0.0045
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0046 0.0624
Trichomonas vaginalis set domain proteins, putative 0.0487 0.107 0.8176
Mycobacterium ulcerans trans-aconitate 2-methyltransferase 0.0043 0.0063 0.0718
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0062 0.0108 0.0108
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0302 0.049
Schistosoma mansoni loxhd1 0.0019 0.001 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0224 0.0473 0.0473
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.001 0.0016
Echinococcus multilocularis nmda type glutamate receptor 0.0028 0.003 0.0049
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0194 0.0406 0.0658
Onchocerca volvulus 0.0042 0.0062 0.0178
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0224 0.0473 0.3046
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Onchocerca volvulus 0.1317 0.2952 1
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0093 0.0178 0.0532
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0057
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0022 0.0119
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0121 0.0241 0.0391
Schistosoma mansoni hypothetical protein 0.0078 0.0143 0.0233
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0057 0.0161
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0224 0.0473 0.0473
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0046 0.0624
Echinococcus granulosus nAChR subunit 0.0121 0.0241 0.0391
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0224 0.0473 0.0768
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0093 0.0178 0.1319
Echinococcus granulosus g protein coupled receptor 0.0042 0.0062 0.0101
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0065 0.0114 0.0114
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0143 0.0233
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0121 0.0241 0.0391
Giardia lamblia Fructose-bisphosphate aldolase 0.0592 0.1308 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0056 0.009
Loa Loa (eye worm) hypothetical protein 0.0033 0.004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0031 0.0189
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Brugia malayi hypothetical protein 0.0056 0.0093 0.0093
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0062 0.0062
Brugia malayi MH2 domain containing protein 0.0234 0.0496 0.0496
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0093 0.0178 0.1141
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0064 0.0446
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0062 0.0101
Mycobacterium ulcerans methyltransferase 0.0043 0.0063 0.0718
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Toxoplasma gondii bicoid-interacting protein BIN3 0.0093 0.0178 0.1141
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Entamoeba histolytica hypothetical protein 0.0123 0.0245 0.1097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0073 0.0118
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0114 0.0186
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0031 0.0038 0.0038
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.0062 0.0101
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0046 0.0307
Onchocerca volvulus 0.0042 0.0062 0.0178
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0073 0.0073
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0121 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Loa Loa (eye worm) LGC-31 protein 0.0121 0.0241 0.0241
Schistosoma mansoni hypothetical protein 0.0048 0.0075 0.0121
Schistosoma mansoni protein arginine n-methyltransferase 0.0699 0.1551 0.2517
Onchocerca volvulus 0.0042 0.0062 0.0178
Brugia malayi TAR-binding protein 0.0062 0.0106 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0046 0.0045
Echinococcus multilocularis peregrin 0.003 0.0034 0.0055
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0093 0.0178 0.0177
Brugia malayi hypothetical protein 0.0019 0.001 0.001
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0062 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0056 0.009
Toxoplasma gondii ABC1 family protein 0.0035 0.0046 0.0289
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0046 0.0475
Brugia malayi Cation transporter family protein 0.0121 0.0241 0.0241
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0224 0.0473 0.0473
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Trypanosoma brucei methyltransferase domain containing protein, putative 0.0043 0.0063 0.0062
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0121 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0158 0.219
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.1308 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0121 0.0241 0.0391
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0046 0.0304
Schistosoma mansoni hypothetical protein 0.0169 0.0349 0.0566
Loa Loa (eye worm) solute carrier family 6 member 4 0.1317 0.2952 0.2952
Echinococcus granulosus sodium and chloride dependent glycine 0.0224 0.0473 0.0768
Mycobacterium ulcerans hypothetical protein 0.0043 0.0063 0.0718
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0064 0.0446
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0062 0.0101
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0247 0.0526 0.0526
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.1308 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0034 0.0055
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0062 0.0101
Echinococcus granulosus neuropeptide s receptor 0.0042 0.0062 0.0101
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0046 0.0304
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0034 0.0055
Schistosoma mansoni acetylcholine receptor subunit beta 0.0056 0.0093 0.0151
Schistosoma mansoni smad 0.0016 0.0002 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0046 0.0045
Echinococcus granulosus methyltransferase protein 5 0.0093 0.0178 0.0289
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0093 0.0178 0.0177
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Onchocerca volvulus 0.0074 0.0134 0.0423
Plasmodium vivax hypothetical protein, conserved 0.003 0.0034 0.0704
Schistosoma mansoni hypothetical protein 0.0093 0.0178 0.0289
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0062 0.0101
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0072 0.013 0.274
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0046 0.0304
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0046
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0046 0.0304
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0046
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.001 0.0016
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0052 0.0084
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0062 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0062 0.0101
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0062 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0046 0.0074
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0121 0.0241 0.0241
Echinococcus granulosus allatostatin A receptor 0.0042 0.0062 0.0101
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0062 0.0101
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) doublecortin family protein 0.0019 0.001 0.001
Onchocerca volvulus 0.0042 0.0062 0.0178
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.001 0.0187
Echinococcus multilocularis zinc finger transcription factor gli2 0.0303 0.0653 0.106
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0062 0.0101
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0224 0.0473 0.0768
Mycobacterium tuberculosis Conserved protein 0.0035 0.0046 0.0624
Brugia malayi beta-lactamase family protein 0.0035 0.0046 0.0046
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0003 0.0005
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0043 0.0063 0.0062
Schistosoma mansoni rab6-interacting 0.0019 0.001 0.0016
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0062 0.0101
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0072 0.013 0.0211
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0121 0.0241 0.0241
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0062 0.0101
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0002 0.0004
Onchocerca volvulus 0.0194 0.0406 0.1346
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0062 0.0101
Onchocerca volvulus 0.0035 0.0046 0.0122
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.1317 0.2952 0.2952
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0062 0.0101
Echinococcus granulosus geminin 0.1036 0.2315 0.3757
Echinococcus granulosus g protein coupled receptor 0.0042 0.0062 0.0101
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0191 0.04 0.0649
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0121 0.0241 0.0391
Echinococcus granulosus orexin receptor type 2 0.0042 0.0062 0.0101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Brugia malayi hypothetical protein 0.0224 0.0473 0.0473
Onchocerca volvulus 0.0042 0.0062 0.0178
Trypanosoma cruzi squalene synthase, putative 0.1063 0.2377 0.2376
Loa Loa (eye worm) hypothetical protein 0.0065 0.0114 0.0114
Brugia malayi G-protein coupled receptor 0.0042 0.0062 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0003 0.0005
Onchocerca volvulus 0.0042 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0194 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0065 0.0114 0.0114
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0093 0.0178 0.0178
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0062 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0191 0.04 0.0649
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0062 0.0101
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0001 0.0001
Mycobacterium ulcerans methyltransferase 0.0043 0.0063 0.0718
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus multilocularis chromobox protein 1 0.0072 0.0129 0.0209
Echinococcus granulosus somatostatin receptor 0.0042 0.0062 0.0101
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0056 0.0093 0.0093
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0062 0.0101
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.0062 0.0101
Schistosoma mansoni hypothetical protein 0.1036 0.2315 0.3757
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0062 0.0062
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0062 0.0101
Echinococcus multilocularis sodium and chloride dependent glycine 0.0224 0.0473 0.0768
Brugia malayi Dopamine receptor protein 2 0.0042 0.0062 0.0062
Loa Loa (eye worm) glutathione reductase 0.0037 0.005 0.005
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0034 0.0214
Loa Loa (eye worm) regulatory protein 0.0043 0.0063 0.0063
Echinococcus granulosus Squalene phytoene synthase 0.0331 0.0717 0.1164
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0143 0.0232
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0064 0.0185
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus fmrfamide receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.1317 0.2952 0.2952
Schistosoma mansoni biogenic amine receptor 0.0042 0.0062 0.0101
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0002 0.0004
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0062 0.0062
Plasmodium falciparum transporter, putative 0.0224 0.0473 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Onchocerca volvulus 0.0042 0.0062 0.0178
Brugia malayi putative neuropeptide receptor 0.0042 0.0062 0.0062
Echinococcus granulosus neuropeptide receptor 0.0042 0.0062 0.0101
Leishmania major C-8 sterol isomerase-like protein 0.4425 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0062 0.0101
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0056 0.0093 0.0151
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0121 0.0241 0.0391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0073 0.0118
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Schistosoma mansoni amine GPCR 0.0042 0.0062 0.0101
Schistosoma mansoni opsin-like receptor 0.0042 0.0062 0.0101
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0062 0.0101
Onchocerca volvulus 0.0224 0.0473 0.1575
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Echinococcus multilocularis nAChR subunit 0.0121 0.0241 0.0391
Loa Loa (eye worm) ACC-1 protein 0.0121 0.0241 0.0241
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0062 0.0101
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0062 0.0101
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0179 0.2488
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0001
Schistosoma mansoni nAChR subunit 0.0121 0.0241 0.0391
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0022 0.0119
Plasmodium falciparum thioredoxin reductase 0.0037 0.005 0.1044
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus multilocularis serotonin transporter 0.1317 0.2952 0.4791
Onchocerca volvulus 0.0056 0.0093 0.0283
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0062 0.0101
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.005 0.0688
Schistosoma mansoni sodium/chloride dependent transporter 0.1317 0.2952 0.4791
Echinococcus granulosus glycine receptor subunit beta 0.0121 0.0241 0.0391
Echinococcus multilocularis somatostatin receptor 0.0042 0.0062 0.0101
Schistosoma mansoni neurotransmitter gated ion channel 0.0065 0.0114 0.0186
Plasmodium vivax amine transporter, putative 0.0224 0.0473 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0224 0.0473 0.0473
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0093 0.0093
Schistosoma mansoni glutamate receptor NMDA 0.0067 0.0117 0.0191
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0062 0.0062
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0121 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0073 0.0118
Brugia malayi excitatory GABA receptor EXP-1A 0.0121 0.0241 0.0241
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.001 0.0187
Onchocerca volvulus 0.0065 0.0114 0.0355
Loa Loa (eye worm) hypothetical protein 0.0224 0.0473 0.0473
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Schistosoma mansoni nAChR subunit 0.0121 0.0241 0.0391
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0143 0.0143
Brugia malayi Pre-SET motif family protein 0.0428 0.0937 0.0937
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0062 0.0101
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0498 0.0808
Onchocerca volvulus 0.0121 0.0241 0.0787
Trypanosoma cruzi squalene synthase, putative 0.1063 0.2377 0.2376
Loa Loa (eye worm) hypothetical protein 0.0078 0.0143 0.0143
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0227 0.0368
Brugia malayi G protein-coupled receptor 0.0042 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0057 0.0393
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0093 0.0093
Echinococcus multilocularis dnaJ subfamily B 0.0799 0.1778 0.2886
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.002 0.0012 0.0157
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0022 0.0119
Echinococcus granulosus cpg binding protein 0.0059 0.0101 0.0163
Brugia malayi CXXC zinc finger family protein 0.0056 0.0093 0.0093
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0143 0.0233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0108 0.0175
Echinococcus granulosus vesicular acetylcholine transporter 0.0219 0.0462 0.0749
Brugia malayi follicle stimulating hormone receptor 0.0267 0.0571 0.0571
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0143 0.0143
Brugia malayi Thioredoxin reductase 0.0037 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Onchocerca volvulus 0.0048 0.0075 0.022
Trypanosoma brucei trypanothione reductase 0.0037 0.005 0.0049
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0093 0.0093
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0158 0.219
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.1308 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0046 0.0074
Schistosoma mansoni sodium/chloride dependent transporter 0.0224 0.0473 0.0768
Onchocerca volvulus 0.0606 0.1339 0.4519
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus multilocularis cpg binding protein 0.0059 0.0101 0.0163
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0224 0.0473 0.0768
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0121 0.0241 0.0241
Mycobacterium tuberculosis Hypothetical protein 0.0043 0.0063 0.0864
Schistosoma mansoni sodium/chloride dependent transporter 0.0224 0.0473 0.0768
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0062 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0046 0.0074
Mycobacterium ulcerans lipase LipD 0.0035 0.0046 0.0475
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0048 0.0079
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0063 0.0864
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0194 0.0406 0.1346
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.001 0.0016
Echinococcus granulosus GPCR family 2 0.0078 0.0143 0.0233
Schistosoma mansoni Smad4 0.0016 0.0002 0.0004
Echinococcus granulosus protein arginine N methyltransferase 8 0.0072 0.013 0.0211
Echinococcus granulosus peregrin 0.003 0.0034 0.0055
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0062 0.0062
Treponema pallidum fructose-bisphosphate aldolase 0.0592 0.1308 0.4406
Brugia malayi MH1 domain containing protein 0.0016 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0019 0.001 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.0937 0.0937
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0062 0.0101
Echinococcus granulosus smad 0.0016 0.0002 0.0004
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Onchocerca volvulus 0.0224 0.0473 0.1575
Onchocerca volvulus 0.0224 0.0473 0.1575
Onchocerca volvulus 0.0042 0.0062 0.0178
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0224 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0106 0.0172
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0224 0.0473 0.0473
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0052 0.0052
Brugia malayi hypothetical protein 0.0235 0.0498 0.0498
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0179 0.2488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0042 0.0062 0.0101
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0056 0.0093 0.0151
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0224 0.0473 0.0768
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0001 0.0001
Brugia malayi GnHR receptor homolog 0.0042 0.0062 0.0062
Leishmania major trypanothione reductase 0.0037 0.005 0.0049
Echinococcus granulosus serotonin transporter 0.1317 0.2952 0.4791
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0028 0.003 0.0049
Schistosoma mansoni adenoreceptor 0.0042 0.0062 0.0101
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.01 0.0162
Loa Loa (eye worm) hypothetical protein 0.0138 0.0279 0.0279
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0078 0.0143 0.0233
Echinococcus granulosus alkylated dna repair protein alkb 8 0.0043 0.0063 0.0102
Schistosoma mansoni nAChR subunit 0.0121 0.0241 0.0391
Onchocerca volvulus 0.0042 0.0062 0.0178
Echinococcus granulosus tm gpcr rhodopsin 0.0555 0.1224 0.1986
Echinococcus granulosus glycine receptor subunit alpha 1 0.0121 0.0241 0.0391
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0093 0.0178 0.0177
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0062 0.0101
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0072 0.013 0.0954
Brugia malayi sulfakinin receptor protein 0.0042 0.0062 0.0062
Echinococcus multilocularis sodium and chloride dependent glycine 0.0224 0.0473 0.0768
Mycobacterium ulcerans methyltransferase 0.0043 0.0063 0.0718
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0056 0.0093 0.0151
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0072 0.013 0.0211
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0062 0.0101
Schistosoma mansoni vesicular amine transporter 0.2733 0.6162 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0143 0.0233
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.001 0.0016
Schistosoma mansoni chromobox protein 0.0072 0.0129 0.0209
Echinococcus multilocularis sex peptide receptor 0.0042 0.0062 0.0101
Mycobacterium tuberculosis Probable HemK protein homolog HemK 0.0043 0.0063 0.0864
Echinococcus granulosus chromobox protein 1 0.0072 0.0129 0.0209
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0093 0.0178 0.0177
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0065 0.0114 0.0114
Schistosoma mansoni nAChR subunit 0.0121 0.0241 0.0391
Onchocerca volvulus 0.0031 0.0038 0.0094
Leishmania major squalene synthase, putative 0.1063 0.2377 0.2376
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus multilocularis GPCR, family 2 0.0078 0.0143 0.0233
Mycobacterium tuberculosis Conserved protein 0.0043 0.0063 0.0864
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.006 0.0097
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0062 0.0101
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0093 0.0178 0.1319
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0002 0.0004
Echinococcus granulosus neuropeptide receptor 0.0042 0.0062 0.0101
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0191 0.04 0.0649
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Echinococcus granulosus glycine receptor subunit beta 0.0121 0.0241 0.0391
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0247 0.0526 0.0526
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0093 0.0178 0.0177
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0001
Echinococcus multilocularis nAChR subunit 0.0065 0.0114 0.0186
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0224 0.0473 0.0768
Onchocerca volvulus 0.0042 0.0062 0.0178
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0121 0.0241 0.0241
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0699 0.1551 0.2517
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0062 0.0101
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0065 0.0114 0.0114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0062 0.0101
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0062 0.0101
Schistosoma mansoni polycystin 1-related 0.0019 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.1317 0.2952 0.2952
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0158 0.1948
Toxoplasma gondii hypothetical protein 0.0043 0.0063 0.0399
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0056 0.0093 0.0093
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0034 0.0214
Loa Loa (eye worm) Carm1-pending protein 0.0699 0.1551 0.1551
Mycobacterium ulcerans hypothetical protein 0.0035 0.0046 0.0475
Schistosoma mansoni lipoxygenase 0.0115 0.0227 0.0368
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Brugia malayi beta-lactamase family protein 0.0035 0.0046 0.0046
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0191 0.04 0.0649
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0121 0.0241 0.0241
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0143 0.0233
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0065 0.0114 0.0114
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0011 0.0017
Schistosoma mansoni sodium-dependent amino acid transporter 0.0224 0.0473 0.0768
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0002 0.0004
Schistosoma mansoni nAChR subunit 0.0121 0.0241 0.0391
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0191 0.04 0.0649
Treponema pallidum sodium- and chloride- dependent transporter 0.1317 0.2952 1
Schistosoma mansoni amine GPCR 0.0042 0.0062 0.0101
Mycobacterium ulcerans methyltransferase 0.0043 0.0063 0.0718
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0121 0.0241 0.0241
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0065 0.0114 0.0114
Brugia malayi G-protein coupled receptor 0.0042 0.0062 0.0062
Schistosoma mansoni neurotransmitter gated ion channel 0.0056 0.0093 0.0151
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0046 0.0304
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0121 0.0241 0.0391
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0022 0.0119
Brugia malayi vesicular acetylcholine transporter unc-17 0.0219 0.0462 0.0462
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0065 0.0114 0.0186
Brugia malayi hypothetical protein 0.0123 0.0245 0.0245
Mycobacterium ulcerans methyltransferase (methylase) 0.0043 0.0063 0.0718
Loa Loa (eye worm) hypothetical protein 0.0224 0.0473 0.0473
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0032 0.0032
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Echinococcus granulosus protein arginine N methyltransferase 7 0.0093 0.0178 0.0289
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0003 0.0005
Plasmodium falciparum phosphoethanolamine N-methyltransferase 0.0043 0.0063 0.1311
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0123 0.0245 0.0244
Mycobacterium tuberculosis Possible conserved permease 0.0043 0.0063 0.0864
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0121 0.0241 0.0391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0073 0.0118
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0224 0.0473 0.0768
Toxoplasma gondii hypothetical protein 0.0224 0.0473 0.3046
Echinococcus multilocularis geminin 0.1036 0.2315 0.3757
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0191 0.04 0.04
Onchocerca volvulus 0.0042 0.0062 0.0178
Loa Loa (eye worm) hypothetical protein 0.0148 0.0302 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0063 0.0436
Brugia malayi chromobox protein homolog 3 0.004 0.0057 0.0057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0073 0.0073
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0121 0.0241 0.0241
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0289 0.0621 0.866
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0046 0.0624
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0189 0.0306
Brugia malayi hypothetical protein 0.0056 0.0093 0.0093
Brugia malayi RNA binding protein 0.0062 0.0106 0.0106
Schistosoma mansoni lipoxygenase 0.008 0.0148 0.0241
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0062 0.0101
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0062 0.0101
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0061 0.0099
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0224 0.0473 0.0473
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0046 0.0624
Brugia malayi neuropeptide F receptor 0.0042 0.0062 0.0062
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0062 0.0062
Schistosoma mansoni amine GPCR 0.0042 0.0062 0.0101
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0062 0.0101
Mycobacterium ulcerans phytoene synthase, CrtB 0.0331 0.0717 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0148 0.0302 0.0302
Plasmodium vivax phosphoethanolamine N-methyltransferase 0.0043 0.0063 0.1311
Brugia malayi hypothetical protein 0.0056 0.0093 0.0093
Brugia malayi jmjC domain containing protein 0.0039 0.0056 0.0056
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0072 0.013 0.274
Brugia malayi Protein arginine N-methyltransferase 0.0093 0.0178 0.0178
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0121 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus hypothetical protein 0.0042 0.0062 0.0101
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0121 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1317 0.2952 0.4791
Schistosoma mansoni hypothetical protein 0.0799 0.1778 0.2886
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0121 0.0241 0.0391
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0062 0.0101
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0331 0.0717 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0227 0.0368
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0592 0.1308 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0046 0.0624
Echinococcus granulosus zinc finger transcription factor gli2 0.0303 0.0653 0.106
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0121 0.0241 0.0391
Onchocerca volvulus 0.0035 0.0046 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0169 0.0349 0.0349
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0062 0.0101
Schistosoma mansoni hypothetical protein 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0331 0.0717 0.0717
Schistosoma mansoni nAChR subunit 0.0121 0.0241 0.0391
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0034
Brugia malayi regulatory protein 0.0043 0.0063 0.0063
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0108 0.0175
Loa Loa (eye worm) hypothetical protein 0.0121 0.0241 0.0241
Onchocerca volvulus 0.0487 0.107 0.3604
Onchocerca volvulus 0.0121 0.0241 0.0787
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0062 0.0101
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0002 0.0002
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Onchocerca volvulus Alhambra homolog 0.003 0.0034 0.0083
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0219 0.0462 0.1536
Brugia malayi Dopamine receptor 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0062 0.0101
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0191 0.04 0.0649
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0051 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0046 0.0948
Trypanosoma brucei C-8 sterol isomerase, putative 0.4425 1 1
Loa Loa (eye worm) ACC-1 protein 0.0121 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0056 0.0093 0.0093
Loa Loa (eye worm) beta-lactamase 0.0035 0.0046 0.0046
Echinococcus granulosus serotonin receptor 0.0042 0.0062 0.0101
Loa Loa (eye worm) histone methyltransferase 0.002 0.0011 0.0011
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0034 0.0055
Brugia malayi jmjC domain containing protein 0.0098 0.0189 0.0189
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0189 0.0306
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0106 0.0172
Schistosoma mansoni biogenic amine receptor 0.0042 0.0062 0.0101
Brugia malayi Calcitonin receptor-like protein seb-1 0.0247 0.0526 0.0526
Mycobacterium tuberculosis Putative transferase 0.0043 0.0063 0.0864
Mycobacterium tuberculosis Possible methyltransferase 0.0043 0.0063 0.0864

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Stimulation of purified Staphylococcus aureus FtsZ polymerization at 80 ug/ml by microtiter plate based light-scattering assay ChEMBL. 23891185
Activity (binding) Stimulation of purified Staphylococcus aureus FtsZ polymerization at 40 ug/ml by microtiter plate based light-scattering assay in presence of 10 mM depolymerizing agent GDP ChEMBL. 23891185

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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