Detailed information for compound 1773125

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 5363.77 | Formula: C237H358N66O77
  • H donors: 79 H acceptors: 78 LogP: -22.73 Rotable bonds: 230
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)O)CCC(=O)O)CCCNC(=N)N)CCC(=O)O)CCCNC(=N)N)CCC(=O)O)CCCNC(=N)N)Cc1ccccc1)Cc1c[nH]c2c1cccc2)CC(=O)N)Cc1c[nH]c2c1cccc2)CC(C)C)CO)C)Cc1c[nH]c2c1cccc2)CCCCN)CC(=O)O)CC(C)C)CCC(=O)O)CC(C)C)CC(C)C)CCC(=O)O)CCC(=O)N)CCC(=O)O)CC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1ccc(cc1)O)N)CO)CC(C)C)Cc1nc[nH]c1)CO)CC(C)C)CCC(=O)O)CCC(=O)O)CO)CCC(=O)N)CC(=O)N)CCC(=O)N)CCC(=O)N)CCC(=O)O
  • InChi: 1S/C237H358N66O77/c1-19-117(15)190(301-226(372)157(89-115(11)12)286-230(376)170(108-306)299-221(367)163(96-126-104-254-110-262-126)296-233(379)191(118(16)20-2)302-227(373)158(90-116(13)14)287-231(377)171(109-307)300-234(380)192(120(18)308)303-194(340)131(240)91-122-50-52-127(309)53-51-122)232(378)281-152(66-79-187(333)334)208(354)276-151(65-78-186(331)332)212(358)298-169(107-305)228(374)280-144(57-70-175(244)313)209(355)293-165(98-177(246)315)222(368)277-143(56-69-174(243)312)203(349)270-141(54-67-172(241)310)201(347)274-147(61-74-182(323)324)204(350)264-135(45-30-32-80-238)200(346)292-164(97-176(245)314)223(369)279-148(62-75-183(325)326)207(353)271-142(55-68-173(242)311)202(348)275-149(63-76-184(327)328)210(356)282-154(86-112(5)6)215(361)284-153(85-111(3)4)214(360)278-150(64-77-185(329)330)211(357)283-155(87-113(7)8)217(363)295-167(100-188(335)336)225(371)267-136(46-31-33-81-239)199(345)289-160(93-123-101-258-132-42-27-24-39-128(123)132)213(359)263-119(17)193(339)297-168(106-304)229(375)285-156(88-114(9)10)216(362)290-162(95-125-103-260-134-44-29-26-41-130(125)134)220(366)294-166(99-178(247)316)224(370)291-161(94-124-102-259-133-43-28-25-40-129(124)133)219(365)288-159(92-121-37-22-21-23-38-121)218(364)268-139(49-36-84-257-237(252)253)198(344)273-146(60-73-181(321)322)206(352)266-138(48-35-83-256-236(250)251)197(343)272-145(59-72-180(319)320)205(351)265-137(47-34-82-255-235(248)249)196(342)269-140(58-71-179(317)318)195(341)261-105-189(337)338/h21-29,37-44,50-53,101-104,110-120,131,135-171,190-192,258-260,304-309H,19-20,30-36,45-49,54-100,105-109,238-240H2,1-18H3,(H2,241,310)(H2,242,311)(H2,243,312)(H2,244,313)(H2,245,314)(H2,246,315)(H2,247,316)(H,254,262)(H,261,341)(H,263,359)(H,264,350)(H,265,351)(H,266,352)(H,267,371)(H,268,364)(H,269,342)(H,270,349)(H,271,353)(H,272,343)(H,273,344)(H,274,347)(H,275,348)(H,276,354)(H,277,368)(H,278,360)(H,279,369)(H,280,374)(H,281,378)(H,282,356)(H,283,357)(H,284,361)(H,285,375)(H,286,376)(H,287,377)(H,288,365)(H,289,345)(H,290,362)(H,291,370)(H,292,346)(H,293,355)(H,294,366)(H,295,363)(H,296,379)(H,297,339)(H,298,358)(H,299,367)(H,300,380)(H,301,372)(H,302,373)(H,303,340)(H,317,318)(H,319,320)(H,321,322)(H,323,324)(H,325,326)(H,327,328)(H,329,330)(H,331,332)(H,333,334)(H,335,336)(H,337,338)(H4,248,249,255)(H4,250,251,256)(H4,252,253,257)/t117-,118-,119-,120+,131-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,190-,191-,192-/m0/s1
  • InChiKey: PBCYLCPQVYHRRV-QKJKBVPKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0628 0.7374
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0066 0.0078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0143
Brugia malayi hypothetical protein 0.0011 0.0007 0.001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0043 0.0207 0.8517
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0106 0.4284
Schistosoma mansoni microtubule-associated protein tau 0.138 0.8501 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0045 0.178
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0045 0.0797
Plasmodium vivax heat shock protein 90, putative 0.0014 0.0026 0.0927
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0031 0.0135 0.0187
Schistosoma mansoni hypothetical protein 0.0229 0.1363 0.1603
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0042
Echinococcus multilocularis muscleblind protein 0.0622 0.3797 0.3797
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0066 0.0078
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0148 0.0802
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0295 0.0347
Loa Loa (eye worm) inositol-1 0.0032 0.0142 0.0196
Trypanosoma brucei trypanothione reductase 0.0049 0.0242 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0028 0.0117 0.0138
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Loa Loa (eye worm) bromodomain containing protein 0.0029 0.0124 0.0171
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.017 0.02
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0045 0.1747
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0066 0.0066
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0004 0.0000019156
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0053 0.0271 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0066 0.0092
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0188 0.026
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Trypanosoma brucei heat shock protein, putative 0.0033 0.0148 0.6052
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0148 0.6052
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0045 0.0492
Schistosoma mansoni fatty acid binding protein 0.1176 0.7238 0.8514
Schistosoma mansoni hypothetical protein 0.0037 0.017 0.02
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0066 0.0092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0022 0.01
Schistosoma mansoni hypothetical protein 0.0339 0.2043 0.2403
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.01
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0032 0.0142 0.2171
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0031 0.0135 0.1554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0066 0.0092
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0207 0.1129
Trypanosoma brucei heat shock protein, putative 0.0033 0.0148 0.6052
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0295 0.0347
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0043 0.0207 0.0286
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0019 0.006 0.007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.064 1
Echinococcus multilocularis tumor protein p63 0.0267 0.1598 0.1598
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0705 0.5798
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0004 0.0000054165
Entamoeba histolytica hypothetical protein 0.0037 0.017 0.093
Trypanosoma brucei heat shock protein, putative 0.0033 0.0148 0.6052
Leishmania major trypanothione reductase 0.0049 0.0242 0.882
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0137 0.2093
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0013 0.0015
Echinococcus multilocularis Kelch repeat type 1 0.0075 0.0405 0.0405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0077 0.0421 0.0495
Echinococcus granulosus fatty acid binding protein FABP2 0.1176 0.7238 0.8514
Echinococcus multilocularis neuropeptide receptor A26 0.0783 0.4798 0.4798
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0092
Echinococcus multilocularis mitogen activated protein kinase 3 0.0043 0.0207 0.0207
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0628 0.5124
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0039 0.1482
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0142 0.5791
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1804 1
Entamoeba histolytica hypothetical protein 0.0037 0.017 0.093
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0066 0.0092
Schistosoma mansoni inositol monophosphatase 0.0032 0.0142 0.0167
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0043 0.0207 0.8517
Echinococcus multilocularis tar DNA binding protein 0.0057 0.0295 0.0295
Echinococcus granulosus nibrin 0.001 0.0004 0.0004
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0045 0.178
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0135 0.0732
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1804 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0313 0.0368
Echinococcus granulosus methyl CpG binding domain protein 2 0.0028 0.0117 0.0138
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0053 0.0271 1
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Plasmodium vivax endoplasmin, putative 0.0033 0.0148 0.6052
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0628 0.5124
Trypanosoma cruzi heat shock protein, putative 0.0014 0.0026 0.0928
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0103 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0066 0.0092
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0018 0.0024
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0149 0.0863 0.1015
Echinococcus granulosus beta LACTamase domain containing family member 0.0031 0.0135 0.0159
Echinococcus granulosus microtubule associated protein 2 0.138 0.8501 1
Schistosoma mansoni zinc finger protein 0.0026 0.0099 0.0117
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0102 0.4103
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0004 0.0004
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0019 0.006 0.006
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0137 0.4526
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0043 0.0207 0.0286
Schistosoma mansoni zinc finger protein 0.0036 0.0164 0.0193
Mycobacterium tuberculosis Conserved protein 0.0031 0.0135 0.0791
Brugia malayi Endoplasmin precursor 0.0033 0.0148 0.0205
Echinococcus granulosus dnaJ subfamily B 0.0818 0.5015 0.5899
Echinococcus granulosus neuropeptide s receptor 0.0783 0.4798 0.5644
Brugia malayi RNA recognition motif domain containing protein 0.0057 0.0295 0.0408
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0148 0.0205
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0066 0.0078
Echinococcus granulosus neuropeptide receptor A26 0.0783 0.4798 0.5644
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0066 0.0066
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0019 0.006 0.007
Loa Loa (eye worm) hypothetical protein 0.0243 0.1448 0.2001
Echinococcus granulosus heat shock protein 0.0033 0.0148 0.0174
Loa Loa (eye worm) RNA binding protein 0.0057 0.0295 0.0408
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0045 0.0063
Echinococcus granulosus cpg binding protein 0.0064 0.0337 0.0397
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0029 0.0029
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0032 0.0142 0.0768
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0135 0.0732
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.0187
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0031 0.0135 0.0791
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0019 0.006 0.2345
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0045 0.0053
Brugia malayi hypothetical protein 0.0011 0.0007 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0051 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0045 0.1747
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0045 0.1747
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0036 0.0036
Brugia malayi mbt repeat family protein 0.0038 0.0175 0.0242
Echinococcus multilocularis zinc finger protein 0.0036 0.0164 0.0164
Giardia lamblia TCP-1 chaperonin subunit beta 0.0019 0.006 0.0311
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0051 0.0051
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0137 0.0137
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0028 0.0117 0.0117
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0039 0.0054
Treponema pallidum heat shock protein 90 0.0027 0.0106 0.0568
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Mycobacterium ulcerans hypothetical protein 0.0031 0.0135 0.1554
Brugia malayi beta-lactamase family protein 0.0031 0.0135 0.0187
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0106 0.0125
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0077 0.0421 0.0421
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0077 0.0421 0.0421
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0295 0.0347
Loa Loa (eye worm) TAR-binding protein 0.0057 0.0295 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0066 0.0092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.01
Entamoeba histolytica hypothetical protein 0.0037 0.017 0.093
Brugia malayi ecdysteroid receptor 0.002 0.0066 0.0092
Echinococcus granulosus lamin 0.0026 0.0103 0.0122
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.1804 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0045 0.1747
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.1448 0.1448
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0135 0.5519
Echinococcus multilocularis endoplasmin 0.0027 0.0106 0.0106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.01
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0005
Echinococcus multilocularis GPCR, family 2 0.0015 0.0036 0.0036
Brugia malayi T-complex protein 1, beta subunit 0.0019 0.006 0.0082
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0029 0.0029
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0702 0.097
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0106 0.0532
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0053 0.0271 0.1985
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0066 0.0066
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0154 0.0213
Echinococcus multilocularis fatty acid binding protein FABP2 0.1176 0.7238 0.7238
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0066 0.0078
Schistosoma mansoni fatty acid binding protein 0.1176 0.7238 0.8514
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0045 0.0655
Trypanosoma brucei ISWI complex protein 0.0026 0.0099 0.4002
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0005
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.1804 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0102 0.4127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0066 0.0092
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0026 0.0026
Echinococcus multilocularis lamin dm0 0.0026 0.0103 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.01
Brugia malayi MH2 domain containing protein 0.0123 0.0702 0.097
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0135 0.0159
Mycobacterium tuberculosis Probable lipase LipD 0.0031 0.0135 0.0791
Schistosoma mansoni cpg binding protein 0.0057 0.0297 0.035
Loa Loa (eye worm) hypothetical protein 0.0068 0.0362 0.0501
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0137 0.5583
Schistosoma mansoni methyl-cpg binding protein mbd 0.0028 0.0117 0.0138
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0031 0.0135 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0066 0.0092
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0705 0.5798
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0039 0.1482
Brugia malayi topoisomerase 0.001 0.0004 0.0005
Echinococcus multilocularis geminin 0.0339 0.2043 0.2043
Giardia lamblia Kinase, CMGC MAPK 0.0043 0.0207 0.1129
Loa Loa (eye worm) hypothetical protein 0.0119 0.068 0.0939
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0066 0.0066
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0137 0.0189
Brugia malayi Muscleblind-like protein 0.0622 0.3797 0.5246
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0295 0.0347
Mycobacterium tuberculosis Conserved protein 0.0031 0.0135 0.0791
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0135 0.5519
Schistosoma mansoni heat shock protein 0.0014 0.0026 0.003
Brugia malayi Cytochrome P450 family protein 0.0016 0.0039 0.0054
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0066 0.0777
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0019 0.006 0.007
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0137 0.5582
Brugia malayi nuclear receptor RXR 0.0011 0.0007 0.001
Echinococcus multilocularis neuropeptide s receptor 0.0783 0.4798 0.4798
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0004 0.004
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0019 0.006 0.2345
Echinococcus granulosus polycomb protein SCMH1 0.0038 0.0175 0.0206
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0066 0.0078
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0045 0.1747
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0137 0.5583
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.01
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Loa Loa (eye worm) hypothetical protein 0.0118 0.0673 0.0929
Schistosoma mansoni hypothetical protein 0.0339 0.2043 0.2403
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0051 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.01
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0242 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0029 0.0035
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0066 0.0078
Brugia malayi hypothetical protein 0.0026 0.0102 0.014
Brugia malayi hypothetical protein 0.0147 0.0852 0.1177
Loa Loa (eye worm) hypothetical protein 0.003 0.0125 0.0173
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0148 0.0802
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0045 0.1747
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1804 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0066 0.0078
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0069 0.0096
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0045 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.01
Brugia malayi heat shock protein 90 0.0033 0.0148 0.0205
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0014 0.0026 0.0302
Loa Loa (eye worm) glutathione reductase 0.0049 0.0242 0.0335
Mycobacterium ulcerans lipase LipD 0.0031 0.0135 0.1554
Loa Loa (eye worm) hypothetical protein 0.0038 0.0175 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0066 0.0092
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0043 0.0207 0.0244
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0029 0.0121 0.1382
Schistosoma mansoni sex comb on midleg homolog 0.0038 0.0175 0.0206
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0026 0.0102 0.014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0077 0.0421 0.0495
Loa Loa (eye worm) hypothetical protein 0.0033 0.0146 0.0202
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0135 0.1554
Echinococcus multilocularis dnaJ subfamily B 0.0818 0.5015 0.5015
Echinococcus multilocularis beta LACTamase domain containing family member 0.0031 0.0135 0.0135
Mycobacterium tuberculosis Probable reductase 0.0111 0.0628 0.5124
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0628 0.5124
Brugia malayi Inositol-1 0.0032 0.0142 0.0196
Loa Loa (eye worm) hypothetical protein 0.0622 0.3797 0.5246
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0103 0.0579 0.0681
Brugia malayi hypothetical protein 0.0243 0.1448 0.2001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0077 0.0421 0.0495
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0297 0.0411
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.0187
Schistosoma mansoni cellular tumor antigen P53 0.0039 0.0183 0.0216
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0135 0.0732
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0148 0.2268
Brugia malayi CXXC zinc finger family protein 0.0057 0.0297 0.0411
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0137 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0077 0.0421 0.0495
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0242 0.1731
Schistosoma mansoni bromodomain containing protein 0.001 0.0005 0.0006
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0066 0.0092
Echinococcus granulosus histone acetyltransferase MYST2 0.0043 0.0207 0.0244
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0241 0.0334
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0043 0.0207 0.7378
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0045 0.0232
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0043 0.0207 0.8517
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0137 0.5583
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0023
Schistosoma mansoni endoplasmin 0.0033 0.0148 0.0174
Echinococcus multilocularis heat shock protein 90 0.0033 0.0148 0.0148
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0045 0.1747
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0005
Brugia malayi RNA binding protein 0.0057 0.0295 0.0408
Echinococcus multilocularis inositol monophosphatase 1 0.0032 0.0142 0.0142
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0137 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0271 0.3158
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0103 0.0579 0.0579
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0207 0.0243
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.01
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0148 0.6052
Schistosoma mansoni cpg binding protein 0.0064 0.0337 0.0397
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0036 0.0036
Giardia lamblia Grp94/Hsp90 0.0027 0.0106 0.0568
Schistosoma mansoni heat shock protein 0.0033 0.0148 0.0174
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0036 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0125 0.0147
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0066 0.0777
Echinococcus multilocularis fatty acid binding protein FABP2 0.1176 0.7238 0.7238
Onchocerca volvulus 0.002 0.0066 0.0777
Schistosoma mansoni bromodomain containing protein 0.0109 0.0616 0.0724
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0148 0.0807
Leishmania major T-complex protein 1, beta subunit, putative 0.0019 0.006 0.1378
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0066 0.0092
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0004 0.0000019156
Entamoeba histolytica hypothetical protein 0.001 0.0004 0.0005
Brugia malayi T-complex protein 1, beta subunit 0.0019 0.006 0.0082
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0045 0.1747
Schistosoma mansoni thyroid hormone receptor 0.002 0.0066 0.0078
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0242 0.0285
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0818 0.5015 0.5899
Echinococcus multilocularis mitogen activated protein kinase 0.0043 0.0207 0.0207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0045 0.1747
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0066 0.0066
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0045 0.0232
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0702 0.097
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.0851 1
Toxoplasma gondii thioredoxin reductase 0.0049 0.0242 0.3748
Loa Loa (eye worm) hypothetical protein 0.0048 0.0241 0.0334
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0137 0.0189
Loa Loa (eye worm) T-complex protein 1 0.0019 0.006 0.0082
Brugia malayi beta-lactamase family protein 0.0031 0.0135 0.0187
Schistosoma mansoni DNA ligase IV 0.001 0.0004 0.0004
Onchocerca volvulus 0.0026 0.0103 0.1214
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0019 0.006 0.0316
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0207 0.1129
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0106 0.0568
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0019 0.006 0.0311
Toxoplasma gondii aldehyde dehydrogenase 0.0053 0.0271 0.4203
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0045 0.0492
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0057 0.0295 0.0408
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0041 0.0194 0.0229
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0106 0.4284
Mycobacterium tuberculosis Possible penicillin-binding protein 0.02 0.1183 1
Echinococcus granulosus GPCR family 2 0.0015 0.0036 0.0042
Entamoeba histolytica hypothetical protein 0.0037 0.017 0.093
Brugia malayi PHD-finger family protein 0.0045 0.0219 0.0302
Brugia malayi hypothetical protein 0.0037 0.017 0.0235
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0036 0.005
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0045 0.0655
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0019 0.0023
Trypanosoma cruzi ISWI complex protein 0.0026 0.0099 0.4002
Loa Loa (eye worm) hypothetical protein 0.0064 0.0338 0.0467
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0053 0.0271 0.0271
Loa Loa (eye worm) endoplasmin 0.0033 0.0148 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0066 0.0092
Brugia malayi Hsp90 protein 0.0014 0.0026 0.0036
Echinococcus granulosus SAM and MBT domain containing protein 0.0038 0.0175 0.0206
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0148 0.2268
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Onchocerca volvulus 0.005 0.0248 0.2914
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0066 0.0078
Brugia malayi nuclear receptor NHR-88 0.002 0.0066 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0135 0.5519
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0026 0.0964
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0019 0.006 0.007
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0032 0.0142 0.0768
Brugia malayi Bromodomain containing protein 0.0064 0.0337 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.01
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0022 0.01
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0137 0.56
Onchocerca volvulus 0.0039 0.0183 0.2153
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0092
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0148 0.6052
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0004 0.0004
Echinococcus granulosus tumor protein p63 0.0267 0.1598 0.188
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0045 0.3017
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0077 0.0421 0.0495
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0135 0.5519
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0066 0.0078
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0248 0.0343
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0032 0.0142 0.1631
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0045 0.0492
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0043 0.0207 0.3192
Toxoplasma gondii t-complex protein beta subunit 0.0019 0.006 0.0879
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0036 0.005
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0102 0.4103
Trichomonas vaginalis heat shock protein, putative 0.002 0.0068 0.0357
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0066 0.0078
Schistosoma mansoni endoplasmin 0.0033 0.0148 0.0174
Brugia malayi nuclear hormone receptor 0.002 0.0066 0.0092
Trypanosoma brucei heat shock protein, putative 0.0033 0.0148 0.6052
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0242 0.0242
Brugia malayi hypothetical protein 0.0119 0.068 0.0939
Schistosoma mansoni nuclear hormone receptor 0.002 0.0066 0.0078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0066 0.0078
Leishmania major hypothetical protein, conserved 0.0031 0.0135 0.4464
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0043 0.0207 0.0207
Echinococcus multilocularis muscleblind protein 1 0.0622 0.3797 0.3797
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0066 0.0777
Brugia malayi MAP kinase sur-1 0.0043 0.0207 0.0286
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0148 0.6052
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0026 0.0348
Brugia malayi DKFZp564C0469 protein 0.001 0.0004 0.0005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0031 0.0135 0.0791
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.017 0.017
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0146 0.0202
Echinococcus granulosus kelch ECH associated protein 1 like 0.0075 0.0404 0.0475
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0008
Echinococcus multilocularis histone acetyltransferase MYST2 0.0043 0.0207 0.0207
Echinococcus multilocularis kelch ECH associated protein 1 0.0075 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0092
Brugia malayi mbt repeat family protein 0.0038 0.0175 0.0242
Brugia malayi steroid hormone receptor 0.002 0.0066 0.0092
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0045 0.1747
Echinococcus granulosus heat shock protein 90 0.0027 0.0106 0.0125
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0007 0.0008
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0027 0.0106 0.1207
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0036 0.005
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.0187
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0043 0.0207 0.8517
Trypanosoma brucei protein kinase, putative 0.0043 0.0207 0.8517
Echinococcus granulosus lamin dm0 0.0026 0.0103 0.0122
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0092
Schistosoma mansoni coup transcription factor 0.002 0.0066 0.0078
Loa Loa (eye worm) hypothetical protein 0.0622 0.3797 0.5246
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0125 0.0147
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0125 0.0147
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0063 0.2495
Trichomonas vaginalis inositol monophosphatase, putative 0.0032 0.0142 0.0768
Loa Loa (eye worm) hypothetical protein 0.0119 0.068 0.0939
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0041 0.0194 0.0194
Echinococcus multilocularis SAM and MBT domain containing protein 0.0038 0.0175 0.0175
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0026 0.0964
Schistosoma mansoni topbp1 0.001 0.0004 0.0004
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0004 0.0005
Onchocerca volvulus 0.0031 0.0135 0.1588
Echinococcus multilocularis nibrin 0.001 0.0004 0.0004
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.1176 0.7238 1
Onchocerca volvulus 0.0031 0.0135 0.1588
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0045 0.0053
Echinococcus granulosus kelch ECH associated protein 1 like 0.0075 0.0404 0.0475
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0148 0.6052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0045 0.1747
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0045 0.0797
Echinococcus granulosus intermediate filament protein 0.0026 0.0103 0.0122
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0045 0.3017
Schistosoma mansoni myelin transcription factor 1 myt1 0.0043 0.0207 0.0244
Echinococcus granulosus inositol monophosphatase 1 0.0032 0.0142 0.0167
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0026 0.0036
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0026 0.0348
Schistosoma mansoni tar DNA-binding protein 0.0057 0.0295 0.0347
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0026 0.0928
Mycobacterium tuberculosis Conserved protein 0.0031 0.0135 0.0791
Brugia malayi Bromodomain containing protein 0.0128 0.0737 0.1018
Schistosoma mansoni topbp1 0.001 0.0004 0.0004
Onchocerca volvulus 0.0147 0.0852 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0041 0.0194 0.0229
Brugia malayi isocitrate dehydrogenase 0.0032 0.0137 0.0189
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0066 0.0092
Schistosoma mansoni hypothetical protein 0.005 0.0248 0.0292
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0019 0.0019
Echinococcus multilocularis cpg binding protein 0.0064 0.0337 0.0337
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0271 0.3158
Echinococcus granulosus replication factor c subunit 1 0.001 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0026 0.0102 0.3087
Trichomonas vaginalis chaperonin, putative 0.0019 0.006 0.0311
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0207 0.1129
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0705 0.5798
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0066 0.0092
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0004 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0039 0.0054
Brugia malayi hypothetical protein 0.001 0.0004 0.0005
Echinococcus multilocularis musashi 0.0026 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0075 0.0405 0.0477
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0045 0.1747
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0066 0.0078
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0066 0.0092
Schistosoma mansoni thyroid hormone receptor 0.002 0.0066 0.0078
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0045 0.0797
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0045 0.0797
Echinococcus granulosus zinc finger protein 0.0036 0.0164 0.0193
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.0187
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0137 0.5583
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0014 0.0026 0.0128
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0103 0.0143
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0077 0.0421 0.0582
Echinococcus granulosus heat shock protein 90 0.0033 0.0148 0.0174
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1804 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0149 0.0863 0.0863
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0142 0.5791
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0029 0.0035
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Echinococcus multilocularis microtubule associated protein 2 0.138 0.8501 0.8501
Echinococcus multilocularis polycomb protein SCMH1 0.0038 0.0175 0.0175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1804 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0705 0.8279
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0066 0.0078
Plasmodium falciparum thioredoxin reductase 0.0049 0.0242 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0029 0.0035
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0066 0.0078
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0697 0.0819
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.1176 0.7238 1
Onchocerca volvulus 0.0031 0.0135 0.1588
Brugia malayi intermediate filament protein 0.0026 0.0103 0.0143
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0066 0.0078
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0106 0.3263
Echinococcus granulosus kelch ECH associated protein 1 0.0075 0.0404 0.0475
Onchocerca volvulus 0.0038 0.0175 0.2051
Schistosoma mansoni myst-related protein 0.001 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0066 0.0092
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0092
Onchocerca volvulus 0.0026 0.0103 0.1214
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0092
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0031 0.0135 0.0791
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0092
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.0271 0.0319
Mycobacterium tuberculosis Probable esterase LipL 0.0031 0.0135 0.0791
Trichomonas vaginalis esterase, putative 0.0031 0.0135 0.0732
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0028 0.0039
Echinococcus granulosus fatty acid binding protein FABP2 0.1176 0.7238 0.8514
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0045 0.0045
Schistosoma mansoni lamin 0.0026 0.0103 0.0122
Loa Loa (eye worm) hypothetical protein 0.0026 0.0101 0.0139
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0019 0.006 0.2345
Brugia malayi Cytochrome P450 family protein 0.0016 0.0039 0.0054
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0137 0.0161
Schistosoma mansoni hypothetical protein 0.0034 0.0154 0.0182
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0029 0.0121 0.0663
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.0187
Plasmodium falciparum glutathione reductase 0.0017 0.0045 0.178
Brugia malayi Thioredoxin reductase 0.0049 0.0242 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.01
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0092
Echinococcus granulosus muscleblind protein 0.0622 0.3797 0.4466
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.005
Schistosoma mansoni heat shock protein 0.0033 0.0148 0.0174
Schistosoma mansoni myst-related protein 0.001 0.0003 0.0003
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0038 0.0175 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0066 0.0092
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0026 0.003
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0242 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0045 0.1747
Plasmodium falciparum T-complex protein 1 subunit beta 0.0019 0.006 0.2376
Loa Loa (eye worm) mbt repeat family protein 0.0038 0.0175 0.0242
Plasmodium vivax heat shock protein, putative 0.0014 0.0026 0.0927
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0313 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.01
Echinococcus granulosus endoplasmin 0.0027 0.0106 0.0125
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0137 0.0804
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0043 0.0207 0.7378
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0241 0.0334
Mycobacterium leprae Probable lipase LipE 0.0031 0.0135 0.1554
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0148 0.0807
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0137 0.2093
Plasmodium falciparum thioredoxin reductase 0.0017 0.0045 0.178
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0028 0.0039
Loa Loa (eye worm) beta-lactamase 0.0031 0.0135 0.0187
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.1804 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0628 0.5124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.01
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0066 0.0092
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0241 0.0334
Trypanosoma brucei heat shock protein, putative 0.0033 0.0148 0.6052
Echinococcus granulosus geminin 0.0339 0.2043 0.2403
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0148 0.6052
Schistosoma mansoni survival motor neuron protein 0.005 0.0248 0.0292
Treponema pallidum NADH oxidase 0.0017 0.0045 0.0232
Plasmodium falciparum endoplasmin, putative 0.002 0.0068 0.2725
Onchocerca volvulus Huntingtin homolog 0.0119 0.068 0.7976
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0066 0.0066
Plasmodium falciparum glutathione reductase 0.0049 0.0242 1
Plasmodium falciparum heat shock protein 90 0.0033 0.0148 0.6068
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.0851 0.708
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0137 0.0137
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0066 0.0066
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.1448 0.1704
Brugia malayi glutathione reductase 0.0049 0.0242 0.0335
Brugia malayi hypothetical protein 0.0017 0.0045 0.0062
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0066 0.0092
Echinococcus multilocularis heat shock protein 90 0.0027 0.0106 0.0106
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0007 0.001
Onchocerca volvulus Huntingtin homolog 0.0119 0.068 0.7976
Brugia malayi beta-lactamase 0.0031 0.0135 0.0187
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.017 0.02
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0148 0.6052
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0027
Trichomonas vaginalis endoplasmin, putative 0.002 0.0068 0.0357
Plasmodium vivax glutathione reductase, putative 0.0049 0.0242 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0036 0.0042
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0066 0.0078
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0023
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0106 0.0568
Onchocerca volvulus 0.0057 0.0297 0.3487
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.0851 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1804 1
Brugia malayi hypothetical protein 0.001 0.0004 0.0005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0628 0.5124
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0005
Schistosoma mansoni cpg binding protein 0.0064 0.0337 0.0397
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1804 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0039 0.0417
Brugia malayi TAR-binding protein 0.0057 0.0295 0.0408
Trypanosoma brucei heat shock protein, putative 0.0033 0.0148 0.6052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0271 0.3158
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0066 0.0078
Schistosoma mansoni inositol monophosphatase 0.0032 0.0142 0.0167
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0077 0.0421 0.0582
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0137 0.0161
Schistosoma mansoni hypothetical protein 0.0033 0.0146 0.0172
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0032 0.0142 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0106 0.0568
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0102 0.1538
Toxoplasma gondii ABC1 family protein 0.0031 0.0135 0.2069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0066 0.0092
Loa Loa (eye worm) hypothetical protein 0.0147 0.0852 0.1177
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0148 0.6052
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0045 0.1747
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0066 0.0092
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0032 0.0142 0.0773
Mycobacterium ulcerans esterase/lipase LipP 0.0031 0.0135 0.1554
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0004 0.0000019156
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0039 0.1482
Leishmania major heat shock protein 83-1 0.0033 0.0148 0.4982
Schistosoma mansoni lamin 0.0026 0.0103 0.0122
Echinococcus multilocularis lamin 0.0026 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0042
Mycobacterium tuberculosis Probable hydrolase 0.0031 0.0135 0.0791
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0066 0.0092
Echinococcus multilocularis heat shock protein 0.0033 0.0148 0.0148
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0102 0.4127
Echinococcus granulosus FTZ F1 alpha 0.002 0.0066 0.0078
Schistosoma mansoni sex comb on midleg homolog 0.0038 0.0175 0.0206
Loa Loa (eye worm) hypothetical protein 0.0043 0.0207 0.0286
Schistosoma mansoni hypothetical protein 0.0026 0.0099 0.0117
Trypanosoma brucei heat shock protein, putative 0.0033 0.0148 0.6052
Mycobacterium tuberculosis Probable lipase LipE 0.0031 0.0135 0.0791
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0066 0.0092
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0043 0.0207 0.8517
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0066 0.0092
Echinococcus granulosus mitogen activated protein kinase 3 0.0043 0.0207 0.0243
Loa Loa (eye worm) MBCTL1 0.0043 0.0207 0.0286
Trypanosoma cruzi ISWI complex protein 0.0026 0.0099 0.4002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1804 1
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0039 0.0054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.0187
Leishmania major cytochrome p450-like protein 0.0016 0.0039 0.0539
Echinococcus granulosus mitogen activated protein kinase 0.0043 0.0207 0.0243
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0031 0.0135 0.0187
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0045 1
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0148 0.6052
Echinococcus granulosus tar DNA binding protein 0.0057 0.0295 0.0347
Leishmania major hypothetical protein, conserved 0.0026 0.0099 0.2989
Brugia malayi Cytochrome P450 family protein 0.004 0.0188 0.026
Trypanosoma brucei heat shock protein, putative 0.0033 0.0148 0.6052
Trichomonas vaginalis penicillin-binding protein, putative 0.0031 0.0135 0.0732
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0038 0.0175 0.2051
Schistosoma mansoni intermediate filament proteins 0.0026 0.0103 0.0122
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0018 0.0024
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0042
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0142 0.5791
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0137 0.0137
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.0106 0.7397
Mycobacterium ulcerans heat shock protein 90 0.0027 0.0106 0.1207
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.01
Onchocerca volvulus 0.001 0.0004 0.0042
Mycobacterium ulcerans beta-lactamase 0.0031 0.0135 0.1554
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0106 0.0568
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.01
Loa Loa (eye worm) hypothetical protein 0.0074 0.0402 0.0556
Trichomonas vaginalis helicase, putative 0.0013 0.0022 0.01
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0103 0.0143
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0102 0.4103
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.0271 0.0319
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0007 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0102 0.4103
Trichomonas vaginalis D-aminoacylase, putative 0.0031 0.0135 0.0732
Loa Loa (eye worm) hypothetical protein 0.0039 0.0183 0.0253
Echinococcus multilocularis kelch ECH associated protein 1 0.0075 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0007
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.1804 1
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0026 0.0123
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0207 0.1129
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0042
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0242 0.0335
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0066 0.0066
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0142 0.4728
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0045 0.1747

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.