Detailed information for compound 178178

Basic information

Technical information
  • TDR Targets ID: 178178
  • Name: (2S)-1-[(2-chlorophenyl)methylcarbamothioyl]- N-[(2S)-1-(N-methylanilino)-1-oxo-3-phenylpro pan-2-yl]pyrrolidine-2-carboxamide
  • MW: 535.1 | Formula: C29H31ClN4O2S
  • H donors: 1 H acceptors: 2 LogP: 5.65 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N(c1ccccc1)C)[C@@H](NC(=O)[C@@H]1CCCN1/C(=N/Cc1ccccc1Cl)/S)Cc1ccccc1
  • InChi: 1S/C29H31ClN4O2S/c1-33(23-14-6-3-7-15-23)28(36)25(19-21-11-4-2-5-12-21)32-27(35)26-17-10-18-34(26)29(37)31-20-22-13-8-9-16-24(22)30/h2-9,11-16,25-26H,10,17-20H2,1H3,(H,31,37)(H,32,35)/t25-,26-/m0/s1
  • InChiKey: KQUGKAAVNOADJT-UIOOFZCWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-N-[(1S)-1-benzyl-2-(N-methylanilino)-2-oxo-ethyl]-1-[(2-chlorophenyl)methylcarbamothioyl]pyrrolidine-2-carboxamide
  • (2S)-N-[(1S)-1-benzyl-2-(N-methylanilino)-2-oxoethyl]-1-[[(2-chlorophenyl)methylamino]-thioxomethyl]-2-pyrrolidinecarboxamide
  • (2S)-1-[(2-chlorophenyl)methylcarbamothioyl]-N-[(2S)-1-[methyl(phenyl)amino]-1-oxo-3-phenyl-propan-2-yl]pyrrolidine-2-carboxamide
  • (2S)-N-[(1S)-1-benzyl-2-keto-2-(N-methylanilino)ethyl]-1-[(2-chlorobenzyl)thiocarbamoyl]pyrrolidine-2-carboxamide
  • (2S)-1-[(2-chlorophenyl)methylcarbamothioyl]-N-[(2S)-1-(methyl-phenylamino)-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
  • (2S)-1-[(2-chlorophenyl)methylcarbamothioyl]-N-[(1S)-2-(methyl-phenyl-amino)-2-oxo-1-(phenylmethyl)ethyl]pyrrolidine-2-carboxamide
  • (2S)-1-[[(2-chlorophenyl)methylamino]-thioxomethyl]-N-[(1S)-2-(methyl-phenylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-pyrrolidinecarboxamide
  • (2S)-N-[(1S)-1-(benzyl)-2-keto-2-(methyl-phenyl-amino)ethyl]-1-[(2-chlorobenzyl)thiocarbamoyl]pyrrolidine-2-carboxamide
  • (2S)-1-[(2-chlorophenyl)methylcarbamothioyl]-N-[(2S)-1-(methyl-phenyl-amino)-1-oxo-3-phenyl-propan-2-yl]pyrrolidine-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0047 0.0047 0.0047
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.01 0.01
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0007 0.0007
Loa Loa (eye worm) beta-lactamase 0.0034 0.0027 0.0027
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0024 0.0024
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0802 0.1238 0.1238
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6365 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0007 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.2166 0.3386 0.3386
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0489 0.0744 0.0744
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0489 0.0744 0.0744
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0027 0.0027
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0024 0.0024
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0005 0.0005
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2656 0.4158 0.4158
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0165 0.0165
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0027 0.0027
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6365 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0422 0.0638 0.0638
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0111 0.0148 0.0148
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0037 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0008 0.0008
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0059 0.0059
Echinococcus granulosus L aminoadipate semialdehyde 0.0079 0.0097 0.0097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.0103 0.0103
Trypanosoma brucei Flagellar Member 6 0.0021 0.0007 0.0007
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0037 0.0577
Echinococcus granulosus ubiquitin specific protease 41 0.0029 0.0019 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0234 0.0343 0.0343
Trichomonas vaginalis CAMK family protein kinase 0.008 0.01 0.01
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0029 0.0019 0.0019
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0021 0.0007 0.0007
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0022 0.0009 0.0518
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0027 0.0027
Trypanosoma brucei trypanothione reductase 0.004 0.0037 0.0037
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0134 0.2095
Trichomonas vaginalis set domain proteins, putative 0.0224 0.0326 0.0326
Trypanosoma cruzi Flagellar Member 6 0.0021 0.0007 0.0007
Brugia malayi RNA binding protein 0.006 0.0068 0.0068
Leishmania major hypothetical protein, conserved 0.0021 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0422 0.0638 0.0638
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0422 0.0638 0.0638
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0009 0.0127
Schistosoma mansoni immunophilin 0.0121 0.0165 0.0165
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0121 0.0165 0.0165
Trypanosoma brucei protein kinase A regulatory subunit 0.0021 0.0007 0.0007
Toxoplasma gondii target of rapamycin (TOR), putative 0.4746 0.745 1
Brugia malayi beta-lactamase family protein 0.0034 0.0027 0.0027
Onchocerca volvulus 0.0028 0.0018 0.0284
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0007 0.0007
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0121 0.0165 0.0165
Mycobacterium ulcerans beta-lactamase 0.0034 0.0027 0.0887
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.0027 0.0428
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0033 0.0026 0.0026
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0029 0.0019 0.0019
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6365 1 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0234 0.0343 0.0343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0059 0.0059
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.0068 0.0068
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0082 0.0103 0.0103
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0047 0.0047
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.0027 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.014 0.0194 0.0194
Brugia malayi serine/threonine-protein kinase plk-2 0.008 0.01 0.01
Plasmodium falciparum glutathione reductase 0.004 0.0037 0.0547
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0029 0.0019 0.0019
Leishmania major cyclic nucleotide-binding protein-like protein 0.0021 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1224 0.1902 0.1902
Brugia malayi Pre-SET motif family protein 0.0028 0.0018 0.0018
Echinococcus multilocularis tar DNA binding protein 0.006 0.0068 0.0068
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0831 0.1282 0.1282
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0024 0.0024
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.0024 0.0024
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0489 0.0744 0.0744
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2223 0.3475 0.3475
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0022 0.0008 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.3804 0.5967 0.5967
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.3453 0.5414 0.5414
Trypanosoma brucei polo-like protein kinase 0.008 0.01 0.01
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0022 0.0009 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0422 0.0638 0.948
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0111 0.0148 0.0148
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.0047 0.0047
Loa Loa (eye worm) MH2 domain-containing protein 0.0101 0.0133 0.0133
Leishmania major cathepsin L-like protease 0.0054 0.0059 0.0059
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0021 0.0007 0.0007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6365 1 1
Loa Loa (eye worm) hypothetical protein 0.1224 0.1902 0.1902
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0021 0.0007 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2223 0.3475 0.3475
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1224 0.1902 0.1902
Leishmania major trypanothione reductase 0.004 0.0037 0.0037
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0194 0.028 0.028
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2166 0.3386 0.3386
Echinococcus granulosus lamin 0.0023 0.001 0.001
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0121 0.0165 0.0165
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0024 0.0024
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0161 0.0228 0.0228
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0121 0.0165 0.0165
Echinococcus granulosus neuropeptide s receptor 0.0438 0.0664 0.0664
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0422 0.0638 0.0638
Loa Loa (eye worm) hypothetical protein 0.0558 0.0853 0.0853
Trichomonas vaginalis CAMK family protein kinase 0.008 0.01 0.01
Echinococcus multilocularis voltage gated potassium channel 0.0047 0.0047 0.0047
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0018 0.0024
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0029 0.0019 0.0019
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0021 0.0007 0.0007
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1364 0.2122 0.2848
Trichomonas vaginalis PIKK family atypical protein kinase 0.3804 0.5967 0.5967
Loa Loa (eye worm) hypothetical protein 0.0047 0.0047 0.0047
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0831 0.1282 0.1282
Loa Loa (eye worm) hypothetical protein 0.0078 0.0096 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0059 0.0059
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0018 0.0018
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0489 0.0744 0.0744
Schistosoma mansoni glutaminase 0.0212 0.0308 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.3785 0.5936 0.5936
Plasmodium vivax hypothetical protein 0.0422 0.0638 0.948
Echinococcus multilocularis expressed conserved protein 0.0022 0.0008 0.0008
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0022 0.0009 0.0011
Brugia malayi Pre-SET motif family protein 0.0197 0.0283 0.0283
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0636 0.0976 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.1224 0.1902 0.1902
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0711 0.1093 0.1093
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0079 0.0097 0.0097
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6365 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0422 0.0638 0.0638
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0161 0.0228 0.0228
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0103 0.0103
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0422 0.0638 0.948
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.0027 0.0428
Loa Loa (eye worm) FKBP5 protein 0.0121 0.0165 0.0165
Mycobacterium ulcerans esterase/lipase LipP 0.0034 0.0027 0.0887
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0422 0.0638 0.0638
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0444 0.0673 0.0673
Trichomonas vaginalis PIKK family atypical protein kinase 0.5072 0.7964 0.7964
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0059 0.0059
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1224 0.1902 0.1902
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.4746 0.745 0.745
Trichomonas vaginalis PIKK family atypical protein kinase 0.3459 0.5422 0.5422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0802 0.1238 0.1238
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0018 0.0018
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0444 0.0673 0.0673
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0636 0.0976 0.0976
Entamoeba histolytica serine/threonine protein kinase, putative 0.008 0.01 0.01
Mycobacterium ulcerans hypothetical protein 0.0021 0.0007 0.0236
Entamoeba histolytica hypothetical protein 0.0422 0.0638 0.0638
Loa Loa (eye worm) glutathione reductase 0.004 0.0037 0.0037
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0444 0.0673 0.0673
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0024 0.0024
Schistosoma mansoni 60S ribosomal protein L21 0.0025 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.5423 0.8517 0.8517
Schistosoma mansoni hypothetical protein 0.0029 0.0019 0.0019
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0444 0.0673 1
Leishmania major hypothetical protein, unknown function 0.0021 0.0007 0.0007
Brugia malayi RNA recognition motif domain containing protein 0.006 0.0068 0.0068
Loa Loa (eye worm) glutaminase 2 0.0212 0.0308 0.0308
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0059 0.0059
Loa Loa (eye worm) transcription factor SMAD2 0.0101 0.0133 0.0133
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0005 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.008 0.01 0.01
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.004 0.004
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1224 0.1902 0.1902
Echinococcus multilocularis muscleblind protein 1 0.0116 0.0156 0.0156
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0105 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.1287 0.2002 0.2002
Loa Loa (eye worm) phosphatidylinositol 3 0.0786 0.1211 0.1211
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0029 0.0019 0.0019
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0165 0.0165
Onchocerca volvulus 0.0021 0.0007 0.0114
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0636 0.0976 0.0976
Brugia malayi Muscleblind-like protein 0.0116 0.0156 0.0156
Onchocerca volvulus 0.0224 0.0326 0.5109
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0024 0.0024
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0121 0.0165 0.0165
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0105 0.0138 0.0138
Loa Loa (eye worm) glutaminase 0.0212 0.0308 0.0308
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0021 0.0007 0.0108
Onchocerca volvulus 0.0079 0.0097 0.1526
Onchocerca volvulus 0.0034 0.0027 0.0428
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0007
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0165 0.0165
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0021 0.0007 0.0007
Echinococcus multilocularis neuropeptide s receptor 0.0438 0.0664 0.0664
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0024 0.0024
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0021 0.0007 0.0114
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0022 0.0008 0.0008
Mycobacterium ulcerans glutaminase 0.0212 0.0308 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0027
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1237 0.1922 0.1922
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0007 0.0007
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0021 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.3453 0.5414 0.5414
Mycobacterium tuberculosis Probable reductase 0.0091 0.0118 0.1844
Trichomonas vaginalis PIKK family atypical protein kinase 0.3459 0.5422 0.5422
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0422 0.0638 0.0857
Leishmania major mitochondrial DNA polymerase beta 0.0234 0.0343 0.0343
Schistosoma mansoni serine/threonine protein kinase 0.008 0.01 0.01
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0021 0.0007 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.2178 0.3405 0.3405
Toxoplasma gondii FATC domain-containing protein 0.1224 0.1902 0.2554
Trichomonas vaginalis PIKK family atypical protein kinase 0.4746 0.745 0.745
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0021 0.0007 0.0007
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0711 0.1093 0.1093
Mycobacterium ulcerans lipase LipD 0.0034 0.0027 0.0887
Echinococcus granulosus voltage gated potassium channel 0.0047 0.0047 0.0047
Onchocerca volvulus 0.0034 0.0027 0.0428
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0942 0.1457 0.1457
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0007
Trypanosoma cruzi major cysteine proteinase, putative 0.0042 0.0041 0.0041
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0021 0.0007 0.0007
Echinococcus granulosus tar DNA binding protein 0.006 0.0068 0.0068
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.0047 0.0047
Brugia malayi Egg laying defective protein 4 0.0022 0.0008 0.0008
Onchocerca volvulus 0.0034 0.0027 0.0428
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0422 0.0638 0.0638
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0019
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0029 0.0019 0.0019
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0022 0.0009 0.0277
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0067 0.008 0.008
Loa Loa (eye worm) intermediate filament protein 0.0023 0.001 0.001
Leishmania major cathepsin L-like protease 0.0054 0.0059 0.0059
Trichomonas vaginalis glutaminase, putative 0.0212 0.0308 0.0308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0059 0.0059
Trypanosoma brucei cAMP binding protein, putative 0.0021 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0034 0.0027 0.0428
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0422 0.0638 0.0638
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0422 0.0638 0.0638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0059 0.0059
Leishmania major hypothetical protein, conserved 0.002 0.0005 0.0005
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6365 1 1
Echinococcus granulosus microtubule associated protein 2 0.0652 0.1001 0.1001
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.0027 0.0428
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0636 0.0976 0.0976
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0021 0.0007 0.0108
Schistosoma mansoni voltage-gated potassium channel 0.0176 0.0251 0.0251
Onchocerca volvulus 0.0422 0.0638 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.0134 0.2095
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0079 0.0097 0.0097
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0024 0.0024
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0022 0.0008 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.4746 0.745 0.745
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0021 0.0007 0.0114
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0161 0.0228 0.0228
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0121 0.0165 0.535
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0037 0.0037
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0121 0.0165 0.2444
Schistosoma mansoni intermediate filament proteins 0.0023 0.001 0.001
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0021 0.0007 0.0007
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0444 0.0673 0.0673
Mycobacterium ulcerans hypothetical protein 0.0021 0.0007 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.3804 0.5967 0.5967
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0029 0.0019 0.0019
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0021 0.0007 0.0114
Brugia malayi intermediate filament protein 0.0023 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.6365 1 1
Brugia malayi beta-lactamase family protein 0.0034 0.0027 0.0027
Leishmania major cathepsin L-like protease 0.0054 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0591 0.0905 0.0905
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0007 0.0007
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.0118 0.1844
Mycobacterium ulcerans regulatory protein 0.0021 0.0007 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0059 0.0059
Mycobacterium ulcerans hypothetical protein 0.0034 0.0027 0.0887
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6365 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.0118 0.1844
Giardia lamblia Phosphatidylinositol 4-kinase 0.0422 0.0638 0.0638
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0161 0.0228 0.0228
Onchocerca volvulus 0.0023 0.001 0.0152
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0165 0.0165
Echinococcus granulosus serine:threonine protein kinase PLK1 0.008 0.01 0.01
Entamoeba histolytica hypothetical protein 0.0422 0.0638 0.0638
Trichomonas vaginalis esterase, putative 0.0034 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0018
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.0118 0.1844
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0007 0.0007
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.0009 0.0009
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0022 0.0009 0.0011
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0636 0.0976 0.0976
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0422 0.0638 0.948
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0422 0.0638 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.5072 0.7964 0.7964
Schistosoma mansoni lamin 0.0023 0.001 0.001
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2178 0.3405 0.3405
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0111 0.0148 0.0148
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0489 0.0744 0.0744
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0422 0.0638 0.0638
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.001 0.001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0034 0.0027 0.0887
Loa Loa (eye worm) phosphatidylinositol 3 0.6365 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0444 0.0673 0.0673
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0019 0.0019
Toxoplasma gondii hypothetical protein 0.0038 0.0033 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.5072 0.7964 0.7964
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0567 0.0867 0.0867
Leishmania major fk506-binding protein 1-like protein 0.0121 0.0165 0.0165
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0024 0.0024
Mycobacterium ulcerans hypothetical protein 0.0021 0.0007 0.0236
Trypanosoma cruzi cruzipain precursor, putative 0.0054 0.0059 0.0059
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.0027 0.0428
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0005 0.0067
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0021 0.0007 0.0007
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0021 0.0007 0.0007
Brugia malayi glutathione reductase 0.004 0.0037 0.0037
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0121 0.0165 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0027 0.0027
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0024 0.0024
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0522 0.0796 0.0796
Mycobacterium tuberculosis Conserved protein 0.0034 0.0027 0.0428
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6365 1 1
Mycobacterium tuberculosis Conserved protein 0.0021 0.0007 0.0114
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0091 0.0118 0.1844
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0422 0.0638 0.0638
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0444 0.0673 0.0673
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0151 0.0211 0.0211
Leishmania major protein kinase, putative 0.0022 0.0008 0.0008
Mycobacterium tuberculosis Conserved protein 0.0034 0.0027 0.0428
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0007 0.0114
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.0024 0.0024
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.008 0.01 0.01
Echinococcus multilocularis Zinc finger, PHD finger 0.0444 0.0673 0.0673
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0036 0.0036
Loa Loa (eye worm) phosphatidylinositol 3 0.0422 0.0638 0.0638
Trypanosoma cruzi cAMP binding protein, putative 0.0021 0.0007 0.0007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.0118 0.1844
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0024 0.0024
Brugia malayi MH2 domain containing protein 0.0101 0.0133 0.0133
Brugia malayi follicle stimulating hormone receptor 0.0182 0.026 0.026
Mycobacterium leprae conserved hypothetical protein 0.0034 0.0027 0.0428
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0422 0.0638 0.0638
Trichomonas vaginalis CAMK family protein kinase 0.008 0.01 0.01
Onchocerca volvulus Serine\/threonine kinase homolog 0.008 0.01 0.1564
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0027 0.0027
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0151 0.0211 0.0211
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.0134 0.2095
Leishmania major protein kinase, putative 0.0022 0.0008 0.0008
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0037 0.0037
Echinococcus multilocularis muscleblind protein 0.0116 0.0156 0.0156
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6365 1 1
Leishmania major regulatory subunit of protein kinase a-like protein 0.0021 0.0007 0.0007
Schistosoma mansoni immunophilin 0.0121 0.0165 0.0165
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0444 0.0673 0.0673
Onchocerca volvulus 0.0021 0.0007 0.0114
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0422 0.0638 0.948
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0444 0.0673 0.0673
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0029 0.0019 0.0019
Leishmania major phosphatidylinositol 3-kinase, putative 0.2166 0.3386 0.3386
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0022 0.0009 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0156 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0802 0.1238 0.1238
Trichomonas vaginalis PIKK family atypical protein kinase 0.2166 0.3386 0.3386
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0422 0.0638 0.0638
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.0027 0.0428
Leishmania major phosphatidylinositol kinase related protein, putative 0.0422 0.0638 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.1224 0.1902 0.1902
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0422 0.0638 0.0638
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0021 0.0007 0.0007
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0.0007 0.001
Echinococcus granulosus muscleblind protein 0.0116 0.0156 0.0156
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0444 0.0673 0.0673
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0026 0.0026
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.008 0.01 0.01
Entamoeba histolytica hypothetical protein 0.0022 0.0009 0.0009
Treponema pallidum cyclic nucleotide binding protein 0.0021 0.0007 0.0441
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.0027 0.0027
Schistosoma mansoni microtubule-associated protein tau 0.0652 0.1001 0.1001
Leishmania major phosphatidylinositol 4-kinase, putative 0.0422 0.0638 0.0638
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0033 0.0026 0.0026
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5077 0.7972 0.7972
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0214 0.0311 0.0311
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0021 0.0007 0.852
Entamoeba histolytica protein kinase rad3, putative 0.1224 0.1902 0.1902
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.0027 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0027 0.0027
Plasmodium falciparum cGMP-dependent protein kinase 0.0022 0.0008 0.0114
Echinococcus multilocularis L aminoadipate semialdehyde 0.0079 0.0097 0.0097
Plasmodium vivax glutathione reductase, putative 0.004 0.0037 0.0547
Schistosoma mansoni tar DNA-binding protein 0.006 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0422 0.0638 0.0638
Plasmodium vivax hypothetical protein, conserved 0.0422 0.0638 0.948
Schistosoma mansoni tar DNA-binding protein 0.006 0.0068 0.0068
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0567 0.0867 0.0867
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0444 0.0673 0.0673
Leishmania major hypothetical protein, conserved 0.0524 0.08 0.08
Schistosoma mansoni immunophilin 0.0105 0.0138 0.0138
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6365 1 1
Treponema pallidum catabolite gene activator (Crp) 0.0021 0.0007 0.0441
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0022 0.0009 0.0134
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.01 0.01
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0029 0.0019 0.0019
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0021 0.0007 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0008 0.0008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0217 0.0316 0.4949
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5077 0.7972 0.7972
Onchocerca volvulus 0.0422 0.0638 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0024 0.0024
Schistosoma mansoni tar DNA-binding protein 0.006 0.0068 0.0068
Mycobacterium leprae Probable lipase LipE 0.0034 0.0027 0.0428
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0005 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0103 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0103 0.0103
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0467 0.0709 0.0709
Trichomonas vaginalis PIKK family atypical protein kinase 0.6365 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0422 0.0638 0.0638
Plasmodium vivax SET domain protein, putative 0.0028 0.0018 0.0269
Echinococcus granulosus cGMP dependent protein kinase 1 0.0022 0.0008 0.0008
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1224 0.1902 0.1902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0422 0.0638 0.0638
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0029 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0059 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0005 0.0005
Onchocerca volvulus 0.0023 0.001 0.0152
Brugia malayi FAT domain containing protein 0.0942 0.1457 0.1457
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0021 0.0007 0.0007
Schistosoma mansoni kinase 0.0041 0.0038 0.0038
Trypanosoma cruzi protein kinase A regulatory subunit 0.0021 0.0007 0.0007
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0024 0.0024
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0021 0.0007 0.0007
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0182 0.026 0.026
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0005 0.0067
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0422 0.0638 0.0638
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0029 0.0019 0.0019
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0021 0.0007 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.008 0.01 0.01
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2223 0.3475 0.3475
Echinococcus granulosus cGMP dependent protein kinase 0.0022 0.0008 0.0008
Echinococcus multilocularis serine protein kinase ATM 0.1224 0.1902 0.1902
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0121 0.0165 0.0165
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0021 0.0007 0.0114
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0021 0.0007 0.0007
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0121 0.0165 0.0165
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0059 0.0059
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0942 0.1457 0.1457
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.004 0.004
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0444 0.0673 0.0673
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.0135 0.0135
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0636 0.0976 0.0976
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0021 0.0007 0.001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0018 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0422 0.0638 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.3453 0.5414 0.5414
Loa Loa (eye worm) hypothetical protein 0.0802 0.1238 0.1238
Trichomonas vaginalis PIKK family atypical protein kinase 0.3459 0.5422 0.5422
Trichomonas vaginalis PIKK family atypical protein kinase 0.4746 0.745 0.745
Mycobacterium ulcerans hypothetical protein 0.0021 0.0007 0.0236
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.0024 0.0024
Echinococcus multilocularis microtubule associated protein 2 0.0652 0.1001 0.1001
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0513 0.0782 0.0782
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0422 0.0638 0.0638
Schistosoma mansoni voltage-gated potassium channel 0.0176 0.0251 0.0251
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0121 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0027
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0021 0.0007 0.0108
Loa Loa (eye worm) phosphatidylinositol 3 0.0067 0.008 0.008
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.006 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0942 0.1457 0.1457
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0037 0.0037
Echinococcus granulosus patatin phospholipase domain containing protein 0.0021 0.0007 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.0103 0.0103
Mycobacterium ulcerans transmembrane transport protein 0.0021 0.0007 0.0236
Leishmania major hypothetical protein, conserved 0.0034 0.0027 0.0027
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0.0007 0.001
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0027 0.0405
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0022 0.0009 0.0277
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6365 1 1
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0021 0.0007 0.0007
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0444 0.0673 0.0904
Trichomonas vaginalis PIKK family atypical protein kinase 0.2178 0.3405 0.3405
Plasmodium falciparum thioredoxin reductase 0.004 0.0037 0.0547
Trypanosoma cruzi cAMP response protein 1, putative 0.0021 0.0007 0.0007
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0021 0.0007 0.0007
Leishmania major phosphatidylinositol 3-kinase, putative 0.0444 0.0673 0.0673
Echinococcus multilocularis 0.0422 0.0638 0.0638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0059 0.0059
Leishmania major protein kinase A regulatory subunit, putative 0.0021 0.0007 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0489 0.0744 0.0744
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0027
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0037 0.0547
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0027
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.0027 0.0428
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0029 0.0019 0.0019
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0831 0.1282 0.1282
Brugia malayi N-terminal motif family protein 0.0021 0.0007 0.0007
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0105 0.0138 0.0138
Loa Loa (eye worm) phosphatidylinositol kinase 0.0422 0.0638 0.0638
Echinococcus multilocularis lamin dm0 0.0023 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.1709 0.2667 0.2667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0059 0.0059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.0134 0.2095
Brugia malayi hypothetical protein 0.002 0.0005 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.3785 0.5936 0.5936
Trypanosoma brucei cAMP response protein 1, putative 0.0021 0.0007 0.0007
Giardia lamblia Kinase, PLK 0.008 0.01 0.01
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0021 0.0007 0.001
Toxoplasma gondii ABC1 family protein 0.0034 0.0027 0.0037
Schistosoma mansoni lamin 0.0023 0.001 0.001
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0009 0.0009
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0024 0.0024
Echinococcus granulosus intermediate filament protein 0.0023 0.001 0.001
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0422 0.0638 0.0857
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0021 0.0007 0.0007
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.0118 0.1844
Echinococcus granulosus lamin dm0 0.0023 0.001 0.001
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0021 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0007
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0121 0.0165 0.0165
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.004 0.004
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0591 0.0905 0.0905
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.0027 0.0428
Loa Loa (eye worm) hypothetical protein 0.0942 0.1457 0.1457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.0059 0.0059
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0037 0.0037
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0021 0.0007 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.008 0.01 0.01
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0021 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0027 0.0027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.0103 0.0103
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0422 0.0638 0.948
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0024 0.0024
Mycobacterium leprae conserved hypothetical protein 0.0422 0.0638 1
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0021 0.0007 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.5072 0.7964 0.7964
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.0103 0.0103
Echinococcus granulosus serine protein kinase ATM 0.1224 0.1902 0.1902
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0079 0.0097 0.0097
Trichomonas vaginalis CAMK family protein kinase 0.008 0.01 0.01
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0021 0.0007 0.0007
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0444 0.0673 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1224 0.1902 0.1902
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0234 0.0343 0.0343
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0558 0.0853 0.0853
Schistosoma mansoni hypothetical protein 0.0021 0.0007 0.0007
Mycobacterium tuberculosis Conserved hypothetical protein 0.0123 0.0168 0.2633
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0558 0.0853 0.0853
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0422 0.0638 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.427 0.67 0.67
Trichomonas vaginalis PIKK family atypical protein kinase 0.4746 0.745 0.745
Loa Loa (eye worm) phosphatidylinositol 3 0.0422 0.0638 0.0638
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0027 0.0027
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0021 0.0007 0.0007
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.0027 0.0027
Trypanosoma cruzi cAMP response protein 1 0.0021 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.6365 1 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0009 0.0127
Loa Loa (eye worm) hypothetical protein 0.0116 0.0156 0.0156
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0082 0.0103 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.1364 0.2122 0.2122
Trichomonas vaginalis conserved hypothetical protein 0.0942 0.1457 0.1457
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.001
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0422 0.0638 0.0857
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0636 0.0976 0.0976
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.1237 0.1922 0.1922
Brugia malayi Thioredoxin reductase 0.004 0.0037 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0197 0.0283 0.0283
Toxoplasma gondii thioredoxin reductase 0.004 0.0037 0.0049
Leishmania major hypothetical protein, conserved 0.0021 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.1364 0.2122 0.2122
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0019 0.0019
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0024 0.0024
Leishmania major peptidylprolyl isomerase-like protein 0.0121 0.0165 0.0165
Loa Loa (eye worm) phosphatidylinositol 3 0.0422 0.0638 0.0638
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.008 0.01 0.01
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0121 0.0165 0.0165
Leishmania major phosphatidylinositol kinase, putative 0.0422 0.0638 0.0638
Loa Loa (eye worm) hypothetical protein 0.0032 0.0024 0.0024
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0444 0.0673 0.0673
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0444 0.0673 0.0673
Echinococcus multilocularis ubiquitin specific protease 41 0.0029 0.0019 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0047 0.0047
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0026 0.0026
Treponema pallidum catabolite gene activator 0.0021 0.0007 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.4746 0.745 0.745
Echinococcus granulosus neuropeptide receptor A26 0.0438 0.0664 0.0664
Trichomonas vaginalis PIKK family atypical protein kinase 0.4746 0.745 0.745
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0121 0.0165 0.0165
Leishmania major hypothetical protein, unknown function 0.0422 0.0638 0.0638
Mycobacterium tuberculosis Conserved hypothetical protein 0.0422 0.0638 1
Echinococcus multilocularis lamin 0.0023 0.001 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0014 0.0014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0558 0.0853 0.0853
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2223 0.3475 0.3475
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0444 0.0673 0.0904
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2223 0.3475 0.3475
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.2166 0.3386 0.3386
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.5072 0.7964 0.7964
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0008 0.0008
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0021 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0009
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0029 0.0019 0.0019
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0422 0.0638 0.0638
Brugia malayi TAR-binding protein 0.006 0.0068 0.0068
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2223 0.3475 0.3475
Treponema pallidum cyclic nucleotide binding protein 0.0021 0.0007 0.0441
Echinococcus multilocularis musashi 0.0023 0.001 0.001
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0489 0.0744 0.0744
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0489 0.0744 0.0744
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0021 0.0007 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0027
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0121 0.0165 0.2444
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0444 0.0673 0.0673
Loa Loa (eye worm) TAR-binding protein 0.006 0.0068 0.0068
Trypanosoma cruzi target of rapamycin kinase 3 0.5077 0.7972 0.7972
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0018 0.0018
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0021 0.0007 0.0007
Echinococcus granulosus cGMP dependent protein kinase 1 0.0022 0.0008 0.0008
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0121 0.0165 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0422 0.0638 0.0638
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0121 0.0165 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0422 0.0638 0.0638
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0009 0.0134
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0444 0.0673 0.0673
Brugia malayi glutaminase DH11.1 0.0212 0.0308 0.0308
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1224 0.1902 0.1902
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1224 0.1902 0.1902
Trichomonas vaginalis immunophilin, putative 0.0121 0.0165 0.0165
Giardia lamblia Hypothetical protein 0.0422 0.0638 0.0638
Entamoeba histolytica hypothetical protein 0.1224 0.1902 0.1902
Trichomonas vaginalis PIKK family atypical protein kinase 0.3459 0.5422 0.5422
Schistosoma mansoni fkbp-rapamycin associated protein 0.1224 0.1902 0.1902
Echinococcus multilocularis neuropeptide receptor A26 0.0438 0.0664 0.0664
Loa Loa (eye worm) AGC/PKG protein kinase 0.0022 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.006 0.0068 0.0068
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0489 0.0744 0.0744
Entamoeba histolytica hypothetical protein 0.0422 0.0638 0.0638
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0444 0.0673 0.0673
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3002 0.4703 0.4703
Echinococcus multilocularis fk506 binding protein 0.0121 0.0165 0.0165
Mycobacterium ulcerans transcriptional regulatory protein 0.0021 0.0007 0.0236
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0021 0.0007 0.0007
Brugia malayi beta-lactamase 0.0034 0.0027 0.0027
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0121 0.0165 0.0165
Loa Loa (eye worm) RNA binding protein 0.006 0.0068 0.0068
Giardia lamblia GTOR 0.6365 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0007 0.0114
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0027
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0049 0.0052 0.0052
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0024 0.0024
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0021 0.0007 0.0007
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2178 0.3405 0.3405
Mycobacterium ulcerans hypothetical protein 0.0123 0.0168 0.5463
Trichomonas vaginalis fk506-binding protein, putative 0.0121 0.0165 0.0165
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0021 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.4131 0.6481 0.6481
Schistosoma mansoni hypothetical protein 0.0422 0.0638 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.2166 0.3386 0.3386
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0121 0.0165 0.0165
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0029 0.0019 0.0019
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.0024 0.0024
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0029 0.0019 0.0019

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 100000 nM In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]-SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R ChEMBL. 9703462
IC50 (binding) = 100000 nM In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]-SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R ChEMBL. 9703462

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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