TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 244.228 | Formula: C11H9FN6
H donors: 1 H acceptors: 4 LogP: 1.68 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccccc1n1nc(c(c1)c1nnn[nH]1)C
InChi: 1S/C11H9FN6/c1-7-8(11-13-16-17-14-11)6-18(15-7)10-5-3-2-4-9(10)12/h2-6H,1H3,(H,13,14,16,17)
InChiKey: REKCKNFNVKNRBE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.023	0.1387	0.138
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0184	0.0176
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0163	0.0155
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.004	0.0203	1
Brugia malayi	Oxysterol-binding protein	0.0035	0.0175	0.0654
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0184	0.0689
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.019	0.1134	0.1128
Brugia malayi	Cytohesin 3	0.0035	0.0175	0.0654
Schistosoma mansoni	hypothetical protein	0.0037	0.0187	0.018
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0035	0.0175	0.0654
Echinococcus multilocularis	Regulator of G protein signaling 20	0.019	0.1134	0.1128
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0163	0.0155
Echinococcus multilocularis	muscleblind protein 1	0.0158	0.0935	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Trichomonas vaginalis	kinesin light chain, putative	0.0035	0.0175	0.1115
Toxoplasma gondii	hypothetical protein	0.0035	0.0175	0.0713
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.1617	1	1
Brugia malayi	A-kinase anchor protein 10, precursor	0.019	0.1134	0.4406
Schistosoma mansoni	serine/threonine protein kinase	0.1617	1	1
Brugia malayi	Muscleblind-like protein	0.0158	0.0935	0.3624
Leishmania major	hypothetical protein, conserved	0.0037	0.0184	0.3206
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.004	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0163	0.0155
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.004	0.0203	0.2382
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.004	0.0203	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Onchocerca volvulus		0.0035	0.0175	0.1072
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0035	0.0175	0.0167
Echinococcus granulosus	oxysterol binding protein 9	0.0035	0.0175	0.0167
Echinococcus granulosus	Rho GTPase activating protein 24	0.0035	0.0175	0.0167
Echinococcus multilocularis	dynamin 1	0.0035	0.0175	0.0167
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0024	0.0016
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0654
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.004	0.0203	1
Leishmania major	folate/biopterin transporter, putative	0.004	0.0203	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0246	0.0238
Toxoplasma gondii	AtPH1 family protein	0.0035	0.0175	0.0713
Brugia malayi	Dynamin	0.0035	0.0175	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0184	0.0176
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0035	0.0175	0.1072
Loa Loa (eye worm)	oxysterol binding protein	0.0035	0.0175	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Onchocerca volvulus		0.0033	0.0163	0.0994
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0184	0.0176
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.004	0.0203	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Echinococcus granulosus	Regulator of G protein signaling 20	0.019	0.1134	0.1128
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0035	0.0175	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0184	0.0176
Trichomonas vaginalis	conserved hypothetical protein	0.019	0.1134	0.7237
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0063	0.0055
Entamoeba histolytica	p21-activated kinase	0.004	0.0203	0.0295
Schistosoma mansoni	axis inhibition protein axin	0.019	0.1134	0.1128
Onchocerca volvulus		0.0259	0.1568	1
Echinococcus multilocularis	regulator of G protein signaling	0.019	0.1134	0.1128
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0184	0.1173
Brugia malayi	Syntrophin-1	0.0035	0.0175	0.0654
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Brugia malayi	hypothetical protein	0.0035	0.0175	0.0654
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0163	0.0155
Echinococcus multilocularis	pdz domain containing protein	0.0035	0.0175	0.0167
Brugia malayi	hypothetical protein	0.019	0.1134	0.4406
Schistosoma mansoni	growth factor receptor-bound protein	0.0035	0.0175	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0246	0.0238
Onchocerca volvulus		0.0035	0.0175	0.1072
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.019	0.1134	0.7237
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0035	0.0175	0.0167
Schistosoma mansoni	zinc finger protein	0.0035	0.0175	0.0167
Schistosoma mansoni	hypothetical protein	0.0035	0.0175	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Loa Loa (eye worm)	hypothetical protein	0.019	0.1134	0.1128
Schistosoma mansoni	serine/threonine-protein kinase	0.004	0.0203	0.0196
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0184	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0035	0.0175	0.0654
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0294	0.112
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0184	0.0176
Echinococcus multilocularis	regulator of G protein signaling 3	0.019	0.1134	0.1128
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0184	0.0176
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.019	0.1134	0.1128
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0035	0.0175	0.0167
Echinococcus granulosus	axis inhibition protein axin	0.019	0.1134	0.1128
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0246	0.0238
Echinococcus granulosus	axis inhibition protein axin	0.019	0.1134	0.1128
Echinococcus multilocularis	regulator of G protein signaling 7	0.019	0.1134	0.1128
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Brugia malayi	hypothetical protein	0.019	0.1134	0.4406
Trichomonas vaginalis	conserved hypothetical protein	0.019	0.1134	0.7237
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0035	0.0175	0.0167
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0184	0.0176
Echinococcus multilocularis	regulator of G protein signaling 3	0.019	0.1134	0.1128
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0012	0.0004
Leishmania major	protein kinase, putative	0.004	0.0203	1
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Brugia malayi	Regulator of G protein signaling domain containing protein	0.019	0.1134	0.4406
Onchocerca volvulus	Putative zinc finger protein	0.0035	0.0175	0.1072
Brugia malayi	PXA domain containing protein	0.019	0.1134	0.4406
Brugia malayi	Uncoordinated protein 104	0.0035	0.0175	0.0654
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0184	0.0176
Schistosoma mansoni	cpg binding protein	0.0033	0.0162	0.0154
Onchocerca volvulus	Protein melted homolog	0.0035	0.0175	0.1072
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0187	0.0702
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.023	0.1387	0.138
Schistosoma mansoni	zinc finger protein	0.0035	0.0175	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.019	0.1134	0.7237
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0035	0.0175	0.1115
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0035	0.0175	0.1115
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0035	0.0175	0.0167
Schistosoma mansoni	hypothetical protein	0.0017	0.0063	0.0055
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0063	0.0055
Loa Loa (eye worm)	AGC/AKT protein kinase	0.004	0.0203	0.0196
Brugia malayi	PXA domain containing protein	0.019	0.1134	0.4406
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1427	0.8821	0.882
Schistosoma mansoni	myotubularin-related protein	0.0035	0.0175	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Echinococcus multilocularis	regulator of G protein signaling 7	0.019	0.1134	0.1128
Echinococcus granulosus	myotubularin protein 13	0.0035	0.0175	0.0167
Echinococcus granulosus	GPCR family 2	0.0017	0.0063	0.0055
Brugia malayi	Variant SH3 domain containing protein	0.0035	0.0175	0.0654
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0246	0.0238
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0035	0.0175	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0187	0.018
Echinococcus granulosus	Pleckstrin y	0.0035	0.0175	0.0167
Echinococcus granulosus	regulator of G protein signaling 7	0.019	0.1134	0.1128
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.004	0.0203	1
Echinococcus granulosus	dnaJ subfamily B	0.0447	0.2732	0.2726
Loa Loa (eye worm)	cytohesin 3	0.0035	0.0175	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Entamoeba histolytica	hypothetical protein	0.019	0.1134	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0228	0.1372	0.1366
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0035	0.0175	0.0654
Trichomonas vaginalis	conserved hypothetical protein	0.019	0.1134	0.7237
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.004	0.0203	1
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Schistosoma mansoni	oxysterol-binding protein 1	0.0035	0.0175	0.0167
Onchocerca volvulus		0.0035	0.0175	0.1072
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.004	0.0203	1
Onchocerca volvulus		0.0035	0.0175	0.1072
Leishmania major	protein kinase, putative	0.004	0.0203	1
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Echinococcus granulosus	cytohesin 1	0.0035	0.0175	0.0167
Brugia malayi	beta-lactamase family protein	0.0037	0.0184	0.0689
Trichomonas vaginalis	centaurin beta, putative	0.0035	0.0175	0.1115
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.042	0.2565	0.256
Trypanosoma brucei	protein kinase, putative	0.004	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.019	0.1134	0.1128
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0654
Schistosoma mansoni	goodpasture antigen-binding protein	0.0035	0.0175	0.0167
Schistosoma mansoni	centaurin alpha	0.0035	0.0175	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Echinococcus multilocularis	beta 1 syntrophin	0.0035	0.0175	0.0167
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0246	0.0238
Brugia malayi	probable spectrin beta chain	0.0035	0.0175	0.0654
Echinococcus multilocularis	dnaJ subfamily B	0.0447	0.2732	0.2726
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Schistosoma mansoni	hypothetical protein	0.0035	0.0175	0.0167
Mycobacterium ulcerans	lipase LipD	0.0037	0.0184	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.019	0.1134	0.7237
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.004	0.0203	0.1296
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.023	0.1387	0.138
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0035	0.0175	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0035	0.0175	0.0167
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.004	0.0203	1
Entamoeba histolytica	hypothetical protein	0.004	0.0203	0.0295
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0184	0.5
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0151	0.056
Loa Loa (eye worm)	hypothetical protein	0.019	0.1134	0.1128
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0246	0.093
Echinococcus multilocularis	myotubularin protein 13	0.0035	0.0175	0.0167
Entamoeba histolytica	hypothetical protein	0.019	0.1134	1
Brugia malayi	Protein kinase domain containing protein	0.004	0.0203	0.0764
Onchocerca volvulus	outspread protein homolog	0.0035	0.0175	0.1072
Brugia malayi	Variant SH3 domain containing protein	0.0035	0.0175	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0935	0.0928
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0035	0.0175	0.0167
Echinococcus granulosus	DCC interacting protein 13 beta	0.0035	0.0175	0.0167
Schistosoma mansoni	cpg binding protein	0.0031	0.0151	0.0143
Schistosoma mansoni	hypothetical protein	0.0447	0.2732	0.2726
Schistosoma mansoni	z-protein (S1r protein)	0.019	0.1134	0.1128
Loa Loa (eye worm)	PH domain-containing protein	0.0035	0.0175	0.0167
Schistosoma mansoni	regulator of G protein signaling	0.019	0.1134	0.1128
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0035	0.0175	0.0167
Onchocerca volvulus		0.0037	0.0184	0.113
Echinococcus multilocularis	muscleblind protein	0.0158	0.0935	0.0928
Brugia malayi	Pre-SET motif family protein	0.0228	0.1372	0.5336
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0294	0.0287
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.042	0.2565	1
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.004	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Echinococcus multilocularis	expressed protein	0.019	0.1134	0.1128
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.004	0.0203	1
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0035	0.0175	0.0167
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0063	0.0055
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0184	0.5
Brugia malayi	regulator of G-protein signaling egl-10	0.019	0.1134	0.4406
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Echinococcus multilocularis	actin binding protein anillin	0.0035	0.0175	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0654
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0024	0.0016
Onchocerca volvulus		0.0035	0.0175	0.1072
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0035	0.0175	0.0167
Trichomonas vaginalis	centaurin/arf, putative	0.0035	0.0175	0.1115
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0654
Echinococcus multilocularis	rac serine:threonine kinase	0.004	0.0203	0.0196
Loa Loa (eye worm)	syntrophin-1	0.0035	0.0175	0.0167
Loa Loa (eye worm)	hypothetical protein	0.019	0.1134	0.1128
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0654
Schistosoma mansoni	hypothetical protein	0.0035	0.0175	0.0167
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0035	0.0175	0.0167
Schistosoma mansoni	serine/threonine-protein kinase	0.004	0.0203	0.0196
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.004	0.0203	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0377	0.0369
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0184	0.1173
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0012	0.0004
Entamoeba histolytica	hypothetical protein	0.019	0.1134	1
Brugia malayi	beta-lactamase	0.0037	0.0184	0.0689
Loa Loa (eye worm)	PXA domain-containing protein	0.019	0.1134	0.1128
Brugia malayi	TBC domain containing protein	0.0035	0.0175	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0294	0.0287
Echinococcus multilocularis	oxysterol binding protein 9	0.0035	0.0175	0.0167
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.004	0.0203	1
Schistosoma mansoni	vav2	0.0035	0.0175	0.0167
Schistosoma mansoni	dynamin	0.0035	0.0175	0.0167
Schistosoma mansoni	regulator of G protein signaling	0.019	0.1134	0.1128
Echinococcus multilocularis	cytohesin 1	0.0035	0.0175	0.0167
Plasmodium falciparum	calcium-dependent protein kinase 7	0.004	0.0203	1
Onchocerca volvulus		0.0031	0.0151	0.0917
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0063	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0935	0.0928
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0063	0.0216
Echinococcus multilocularis	Oxysterol binding protein 11	0.0035	0.0175	0.0167
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Schistosoma mansoni	hypothetical protein	0.0017	0.0063	0.0055
Onchocerca volvulus		0.0037	0.0184	0.113
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.019	0.1134	0.1128
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0184	0.3206
Loa Loa (eye worm)	Plekhf2 protein	0.0035	0.0175	0.0167
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Trypanosoma cruzi	Protein kinase B	0.004	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0184	0.0176
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0063	0.0055
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0654
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.1413	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0023	0.0059
Brugia malayi	Oxysterol binding protein	0.0035	0.0175	0.0654
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.023	0.1387	0.138
Trichomonas vaginalis	centaurin gamma, putative	0.0035	0.0175	0.1115
Entamoeba histolytica	hypothetical protein	0.004	0.0203	0.0295
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0184	0.1173
Trypanosoma cruzi	NIMA-related kinase, putative	0.004	0.0203	1
Echinococcus multilocularis	oxysterol binding protein 1	0.0035	0.0175	0.0167
Schistosoma mansoni	axis inhibition protein axin	0.019	0.1134	0.1128
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0035	0.0175	0.0167
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0246	0.0238
Loa Loa (eye worm)	hypothetical protein	0.019	0.1134	0.1128
Schistosoma mansoni	regulator of G protein signaling	0.019	0.1134	0.1128
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1427	0.8821	0.882
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0163	0.0155
Echinococcus granulosus	calcium dependent secretion activator 1	0.0035	0.0175	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Schistosoma mansoni	serine/threonine protein kinase	0.1617	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0163	0.0155
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0063	0.0055
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0184	0.1173
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0184	0.5241
Trichomonas vaginalis	centaurin/arf, putative	0.0035	0.0175	0.1115
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0035	0.0175	0.2995
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0175	0.2995
Echinococcus multilocularis	oxysterol binding protein 3	0.0035	0.0175	0.0167
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.019	0.1134	0.1128
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0184	0.3206
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.023	0.1387	0.5392
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0184	0.5
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0035	0.0175	0.0167
Schistosoma mansoni	hypothetical protein	0.0035	0.0175	0.0167
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0654
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0024	0.0016
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.019	0.1134	0.1128
Onchocerca volvulus		0.0035	0.0175	0.1072
Echinococcus multilocularis	Pleckstrin y	0.0035	0.0175	0.0167
Leishmania major	serine/threonine-protein kinase a, putative	0.004	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.019	0.1134	0.1128
Echinococcus granulosus	regulator of G protein signaling 7	0.019	0.1134	0.1128
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0151	0.0143
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0294	0.112
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0035	0.0175	0.0167
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0654
Onchocerca volvulus		0.0035	0.0175	0.1072
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0035	0.0175	0.0167
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0035	0.0175	0.0167
Echinococcus multilocularis	Pleckstrin y	0.0035	0.0175	0.0167
Schistosoma mansoni	oxysterol-binding protein 1	0.0035	0.0175	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Brugia malayi	regulator of G-protein signaling rgs-7	0.019	0.1134	0.4406
Toxoplasma gondii	Oxysterol-binding protein	0.0035	0.0175	0.0713
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.004	0.0203	0.1296
Echinococcus granulosus	expressed protein	0.019	0.1134	0.1128
Schistosoma mansoni	syntrophin	0.0035	0.0175	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0184	0.0176
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0654
Trichomonas vaginalis	protein transport protein sec7, putative	0.0035	0.0175	0.1115
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0035	0.0175	0.0167
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0063	0.0216
Schistosoma mansoni	cpg binding protein	0.0033	0.0162	0.0154
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0246	0.0238
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0035	0.0175	0.1115
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0012	0.0004
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0184	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0184	0.1173
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0035	0.0175	0.0167
Echinococcus granulosus	oxysterol binding protein 1	0.0035	0.0175	0.0167
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0035	0.0175	0.0167
Loa Loa (eye worm)	rho-GTPase-activating	0.0035	0.0175	0.0167
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0035	0.0175	0.0167
Loa Loa (eye worm)	RGS-3 protein	0.019	0.1134	0.1128
Loa Loa (eye worm)	uncoordinated protein 104	0.0035	0.0175	0.0167
Echinococcus granulosus	regulator of G protein signaling 3	0.019	0.1134	0.1128
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Echinococcus granulosus	oxysterol binding protein 3	0.0035	0.0175	0.0167
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Brugia malayi	Plekhf2 protein	0.0035	0.0175	0.0654
Trichomonas vaginalis	hypothetical protein	0.0035	0.0175	0.1115
Toxoplasma gondii	ABC1 family protein	0.0037	0.0184	0.1248
Echinococcus multilocularis	axis inhibition protein axin	0.019	0.1134	0.1128
Brugia malayi	Pre-SET motif family protein	0.0033	0.0163	0.0606
Echinococcus granulosus	Oxysterol binding protein 11	0.0035	0.0175	0.0167
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.004	0.0203	1
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0012	0.0004
Brugia malayi	beta-lactamase family protein	0.0037	0.0184	0.0689
Echinococcus granulosus	beta 1 syntrophin	0.0035	0.0175	0.0167
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0035	0.0175	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0184	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Trichomonas vaginalis	centaurin alpha, putative	0.0035	0.0175	0.1115
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.019	0.1134	0.1128
Schistosoma mansoni	hypothetical protein	0.0017	0.0063	0.0055
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0035	0.0175	0.0167
Echinococcus granulosus	pleckstrin y domain containing family A	0.0035	0.0175	0.0167
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0246	0.0238
Brugia malayi	Pleckstrin Homology Domain	0.0035	0.0175	0.0654
Schistosoma mansoni	hypothetical protein	0.0035	0.0175	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Echinococcus granulosus	cpg binding protein	0.0033	0.0162	0.0154
Echinococcus granulosus	GRB2 associated binding protein 3	0.0035	0.0175	0.0167
Toxoplasma gondii	hypothetical protein	0.0035	0.0175	0.0713
Echinococcus multilocularis	cpg binding protein	0.0033	0.0162	0.0154
Plasmodium vivax	PH domain containing protein	0.0035	0.0175	0.2995
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0035	0.0175	0.2995
Echinococcus multilocularis	beta adrenergic receptor kinase	0.1617	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0063	0.0055
Trichomonas vaginalis	esterase, putative	0.0037	0.0184	0.1173
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0035	0.0175	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Trypanosoma cruzi	NIMA-related kinase, putative	0.004	0.0203	1
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0035	0.0175	0.1115
Echinococcus multilocularis	Pleckstrin y	0.0035	0.0175	0.0167
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0035	0.0175	0.0167
Schistosoma mansoni	regulator of G protein signaling	0.019	0.1134	0.1128
Echinococcus granulosus	Pleckstrin y	0.0035	0.0175	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Brugia malayi	MAX-1A	0.0035	0.0175	0.0654
Echinococcus multilocularis	axis inhibition protein axin	0.019	0.1134	0.1128
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Schistosoma mansoni	regulator of G protein signaling	0.019	0.1134	0.1128
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0035	0.0175	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Echinococcus granulosus	regulator of G protein signaling 3	0.019	0.1134	0.1128
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.0333	1
Trichomonas vaginalis	protein transport protein sec7, putative	0.0035	0.0175	0.1115
Schistosoma mansoni	serine/threonine protein kinase	0.042	0.2565	0.256
Echinococcus granulosus	pdz domain containing protein	0.0035	0.0175	0.0167
Schistosoma mansoni	hypothetical protein	0.0017	0.0063	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.019	0.1134	0.7237
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0184	0.5
Brugia malayi	Dynamin	0.0035	0.0175	0.0654
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0035	0.0175	0.0713
Trichomonas vaginalis	alpha chimerin, putative	0.0035	0.0175	0.1115
Schistosoma mansoni	rho gtpase activating protein	0.0035	0.0175	0.0167
Echinococcus granulosus	muscleblind protein	0.0158	0.0935	0.0928
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0035	0.0175	0.0167
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0035	0.0175	0.000000088419
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0035	0.0175	0.1115
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1115
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0035	0.0175	0.0167
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0184	0.3206
Onchocerca volvulus		0.0037	0.0184	0.113
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0163	0.0155
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0184	0.0176
Brugia malayi	Cadps2 protein	0.0035	0.0175	0.0654
Echinococcus granulosus	Pleckstrin y	0.0035	0.0175	0.0167
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.004	0.0203	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.004	0.0203	1
Echinococcus granulosus	dynamin 1	0.0035	0.0175	0.0167
Toxoplasma gondii	protein kinase domain-containing protein	0.004	0.0203	0.2382
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.004	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0167
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0035	0.0175	0.1072
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Brugia malayi	Regulator of G protein signaling domain containing protein	0.019	0.1134	0.4406
Echinococcus granulosus	serine/threonine protein kinase	0.004	0.0203	0.0196
Trichomonas vaginalis	set domain proteins, putative	0.0259	0.1568	1
Schistosoma mansoni	goodpasture antigen-binding protein	0.0035	0.0175	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Schistosoma mansoni	dynamin	0.0035	0.0175	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1296
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0035	0.0175	0.1115
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0012	0.0004
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0151	0.0143
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0163	0.0155

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 225.41 uM	Antipromastigote activity against Leishmania braziliensis MCAN/BR/98/R619 after 24 hrs by MTT assay	ChEMBL.	24125880

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2441495

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1791595