TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.936 | Formula: C21H22ClN3O2S
H donors: 2 H acceptors: 1 LogP: 5 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: S=C(Nc1ccc(cc1)Cl)NCc1cn(c2c1cccc2)C(=O)OC(C)(C)C
InChi: 1S/C21H22ClN3O2S/c1-21(2,3)27-20(26)25-13-14(17-6-4-5-7-18(17)25)12-23-19(28)24-16-10-8-15(22)9-11-16/h4-11,13H,12H2,1-3H3,(H2,23,24,28)
InChiKey: OAEWGNPHLVECCD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	PH domain containing protein	0.0046	0.0184	0.0478
Onchocerca volvulus		0.0046	0.0184	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0135	0.1678
Schistosoma mansoni	dynamin	0.0046	0.0184	0.0176
Brugia malayi	Uncoordinated protein 104	0.0046	0.0184	0.0478
Brugia malayi	MAX-1A	0.0046	0.0184	0.0478
Schistosoma mansoni	z-protein (S1r protein)	0.0267	0.123	0.1223
Brugia malayi	Cytohesin 3	0.0046	0.0184	0.0478
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Loa Loa (eye worm)	RGS-3 protein	0.0267	0.123	0.1215
Onchocerca volvulus		0.0046	0.0184	0.0706
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0135	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0267	0.123	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0135	0.0118
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Schistosoma mansoni	centaurin alpha	0.0046	0.0184	0.0176
Brugia malayi	PH domain containing protein	0.0046	0.0184	0.0478
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0046	0.0184	0.1497
Echinococcus granulosus	calcium dependent secretion activator 1	0.0046	0.0184	0.0176
Schistosoma mansoni	hypothetical protein	0.0017	0.0046	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0118
Onchocerca volvulus		0.0046	0.0184	0.0706
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Brugia malayi	PH domain containing protein	0.0046	0.0184	0.0478
Echinococcus multilocularis	myotubularin protein 13	0.0046	0.0184	0.0176
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0046	0.0184	0.1497
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0181	0.0172
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0046	0.0184	0.0176
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0119	0.0111
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0267	0.123	0.1223
Schistosoma mansoni	rho gtpase activating protein	0.0046	0.0184	0.0176
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0046	0.0184	0.0176
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Toxoplasma gondii	protein kinase domain-containing protein	0.0052	0.0214	0.7624
Toxoplasma gondii	ABC1 family protein	0.0036	0.0135	0.1279
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0135	0.1101
Echinococcus granulosus	Pleckstrin y	0.0046	0.0184	0.0176
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0046	0.0184	0.1497
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0135	0.1101
Trypanosoma brucei	PH domain containing protein, putative	0.0046	0.0184	0.6162
Schistosoma mansoni	serine/threonine protein kinase	0.2124	1	1
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0046	0.0184	0.0176
Trichomonas vaginalis	centaurin/arf, putative	0.0046	0.0184	0.1497
Echinococcus multilocularis	oxysterol binding protein 3	0.0046	0.0184	0.0176
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0052	0.0214	1
Schistosoma mansoni	cpg binding protein	0.0032	0.0119	0.011
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0046	0.0184	0.0167
Plasmodium vivax	PH domain containing protein	0.0046	0.0184	0.6806
Echinococcus multilocularis	regulator of G protein signaling 7	0.0267	0.123	0.1223
Echinococcus granulosus	myotubularin protein 13	0.0046	0.0184	0.0176
Leishmania major	hypothetical protein, conserved	0.0046	0.0184	0.6162
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0135	0.1101
Brugia malayi	Dynamin	0.0046	0.0184	0.0478
Trichomonas vaginalis	esterase, putative	0.0036	0.0135	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0267	0.123	0.1215
Echinococcus granulosus	Regulator of G protein signaling 20	0.0267	0.123	0.1223
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0244	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0485	0.2257	0.2243
Trypanosoma cruzi	hypothetical protein	0.0046	0.0184	0.6162
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0119	0.0111
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0135	0.0127
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Schistosoma mansoni	zinc finger protein	0.0046	0.0184	0.0176
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0046	0.0184	0.0176
Brugia malayi	regulator of G-protein signaling egl-10	0.0267	0.123	0.3464
Schistosoma mansoni	axis inhibition protein axin	0.0267	0.123	0.1223
Onchocerca volvulus		0.0046	0.0184	0.0706
Schistosoma mansoni	hypothetical protein	0.0036	0.0137	0.0129
Trypanosoma cruzi	hypothetical protein	0.0046	0.0184	0.6162
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0118
Echinococcus multilocularis	muscleblind protein 1	0.0168	0.076	0.0752
Echinococcus granulosus	oxysterol binding protein 3	0.0046	0.0184	0.0176
Echinococcus granulosus	pdz domain containing protein	0.0046	0.0184	0.0176
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0181	0.0468
Entamoeba histolytica	protein kinase, putative	0.0052	0.0214	0.029
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0052	0.0214	1
Echinococcus granulosus	pleckstrin y domain containing family A	0.0046	0.0184	0.0176
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0181	0.0172
Echinococcus multilocularis	cpg binding protein	0.0032	0.0119	0.011
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0184	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0046	0.0184	0.0176
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0135	0.0127
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0046	0.0184	0.6162
Echinococcus multilocularis	dynamin 1	0.0046	0.0184	0.0176
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0052	0.0214	1
Leishmania major	folate/biopterin transporter, putative	0.0052	0.0214	1
Trypanosoma cruzi	NIMA-related kinase, putative	0.0052	0.0214	1
Trypanosoma cruzi	hypothetical protein	0.0046	0.0184	0.6162
Brugia malayi	Plekhf2 protein	0.0046	0.0184	0.0478
Brugia malayi	Pre-SET motif family protein	0.022	0.1008	0.2829
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Schistosoma mansoni	hypothetical protein	0.0017	0.0046	0.0038
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0214	0.029
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Schistosoma mansoni	serine/threonine-protein kinase	0.0052	0.0214	0.0206
Trichomonas vaginalis	centaurin/arf, putative	0.0046	0.0184	0.1497
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0485	0.2257	0.6395
Echinococcus multilocularis	pdz domain containing protein	0.0046	0.0184	0.0176
Brugia malayi	TBC domain containing protein	0.0046	0.0184	0.0478
Onchocerca volvulus		0.0032	0.0119	0.0084
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0135	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0046	0.0084
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0181	0.0172
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Schistosoma mansoni	goodpasture antigen-binding protein	0.0046	0.0184	0.0176
Schistosoma mansoni	myotubularin-related protein	0.0046	0.0184	0.0176
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0277	0.0268
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0052	0.0214	1
Echinococcus granulosus	regulator of G protein signaling 3	0.0267	0.123	0.1223
Echinococcus multilocularis	actin binding protein anillin	0.0046	0.0184	0.0176
Schistosoma mansoni	hypothetical protein	0.0017	0.0046	0.0038
Echinococcus multilocularis	beta 1 syntrophin	0.0046	0.0184	0.0176
Schistosoma mansoni	hypothetical protein	0.0046	0.0184	0.0176
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0216	0.0569
Brugia malayi	Cadps2 protein	0.0046	0.0184	0.0478
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0267	0.123	0.1223
Schistosoma mansoni	regulator of G protein signaling	0.0267	0.123	0.1223
Trichomonas vaginalis	protein transport protein sec7, putative	0.0046	0.0184	0.1497
Schistosoma mansoni	goodpasture antigen-binding protein	0.0046	0.0184	0.0176
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0052	0.0214	1
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0046	0.0184	0.0478
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0119	0.0111
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0052	0.0214	1
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0052	0.0214	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0119	0.0111
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0184	0.6162
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Loa Loa (eye worm)	hypothetical protein	0.0168	0.076	0.0744
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0046	0.0038
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Echinococcus multilocularis	expressed protein	0.0267	0.123	0.1223
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0111	0.0102
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0046	0.0184	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Schistosoma mansoni	oxysterol-binding protein 1	0.0046	0.0184	0.0176
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0052	0.0214	1
Schistosoma mansoni	cpg binding protein	0.003	0.0111	0.0102
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Entamoeba histolytica	protein kinase, putative	0.0052	0.0214	0.029
Echinococcus granulosus	dnaJ subfamily B	0.0431	0.2005	0.1998
Brugia malayi	regulator of G-protein signaling rgs-7	0.0267	0.123	0.3464
Onchocerca volvulus		0.0036	0.0135	0.0238
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Brugia malayi	Oxysterol binding protein	0.0046	0.0184	0.0478
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0046	0.0038
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Schistosoma mansoni	dynamin	0.0046	0.0184	0.0176
Brugia malayi	hypothetical protein	0.0267	0.123	0.3464
Loa Loa (eye worm)	hypothetical protein	0.0267	0.123	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0267	0.123	0.1215
Entamoeba histolytica	protein kinase, putative	0.0052	0.0214	0.029
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0184	0.0176
Brugia malayi	Syntrophin-1	0.0046	0.0184	0.0478
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0135	0.5
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0046	0.0184	0.0478
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1857	0.8738	0.8736
Brugia malayi	Pre-SET motif family protein	0.0032	0.0119	0.0293
Schistosoma mansoni	serine/threonine-protein kinase	0.0052	0.0214	0.0206
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Schistosoma mansoni	serine/threonine protein kinase	0.2124	1	1
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0135	0.5
Schistosoma mansoni	zinc finger protein	0.0046	0.0184	0.0176
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0017	0.0009
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0046	0.0184	0.1497
Onchocerca volvulus	Putative zinc finger protein	0.0046	0.0184	0.0706
Leishmania major	hypothetical protein, conserved	0.0046	0.0184	0.6162
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0046	0.0184	0.0176
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0052	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Entamoeba histolytica	hypothetical protein	0.0052	0.0214	0.029
Brugia malayi	PH domain containing protein	0.0046	0.0184	0.0478
Echinococcus granulosus	axis inhibition protein axin	0.0267	0.123	0.1223
Trichomonas vaginalis	protein transport protein sec7, putative	0.0046	0.0184	0.1497
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0267	0.123	0.1223
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0137	0.012
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0046	0.0029
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0046	0.0184	0.1497
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Brugia malayi	PH domain containing protein	0.0046	0.0184	0.0478
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0267	0.123	0.1223
Trichomonas vaginalis	conserved hypothetical protein	0.0267	0.123	1
Trichomonas vaginalis	conserved hypothetical protein	0.0267	0.123	1
Brugia malayi	Oxysterol-binding protein	0.0046	0.0184	0.0478
Schistosoma mansoni	cpg binding protein	0.0032	0.0119	0.011
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0046	0.0184	0.0176
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0216	0.0199
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0046	0.0184	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Trichomonas vaginalis	centaurin alpha, putative	0.0046	0.0184	0.1497
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0135	0.5
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0267	0.123	1
Trypanosoma cruzi	hypothetical protein	0.0046	0.0184	0.6162
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0046	0.0184	0.1497
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0181	0.0172
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0214	0.029
Echinococcus multilocularis	axis inhibition protein axin	0.0267	0.123	0.1223
Onchocerca volvulus	outspread protein homolog	0.0046	0.0184	0.0706
Brugia malayi	Pleckstrin Homology Domain	0.0046	0.0184	0.0478
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0046	0.0184	0.6162
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0046	0.0184	0.000000059556
Onchocerca volvulus		0.0036	0.0135	0.0238
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0135	0.1101
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.0184	0.0478
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0111	0.0094
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0214	0.0565
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Trypanosoma cruzi	hypothetical protein	0.0046	0.0184	0.6162
Onchocerca volvulus		0.0046	0.0184	0.0706
Entamoeba histolytica	protein kinase, putative	0.0052	0.0214	0.029
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0046	0.0029
Echinococcus granulosus	regulator of G protein signaling 7	0.0267	0.123	0.1223
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0046	0.0038
Echinococcus granulosus	Oxysterol binding protein 11	0.0046	0.0184	0.0176
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0052	0.0214	1
Brugia malayi	beta-lactamase	0.0036	0.0135	0.0339
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.022	0.1008	0.0992
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0267	0.123	0.1223
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0046	0.0184	0.0176
Loa Loa (eye worm)	Plekhf2 protein	0.0046	0.0184	0.0167
Schistosoma mansoni	hypothetical protein	0.0431	0.2005	0.1998
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0135	0.5
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0046	0.0184	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0046	0.0184	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.0184	0.0478
Echinococcus granulosus	axis inhibition protein axin	0.0267	0.123	0.1223
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1857	0.8738	0.8736
Schistosoma mansoni	vav2	0.0046	0.0184	0.0176
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0046	0.0184	0.6806
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0046	0.0184	0.6806
Brugia malayi	CXXC zinc finger family protein	0.003	0.0111	0.0268
Echinococcus granulosus	GPCR family 2	0.0017	0.0046	0.0038
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0181	0.0172
Onchocerca volvulus		0.0251	0.1151	1
Schistosoma mansoni	regulator of G protein signaling	0.0267	0.123	0.1223
Toxoplasma gondii	Oxysterol-binding protein	0.0046	0.0184	0.5189
Loa Loa (eye worm)	syntrophin-1	0.0046	0.0184	0.0167
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0119	0.0111
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0184	0.6162
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0046	0.0184	0.0176
Brugia malayi	hypothetical protein	0.0267	0.123	0.3464
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0052	0.0214	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0135	0.0127
Loa Loa (eye worm)	oxysterol binding protein	0.0046	0.0184	0.0167
Schistosoma mansoni	serine/threonine protein kinase	0.0752	0.3519	0.3513
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0046	0.0184	0.0176
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0214	0.029
Loa Loa (eye worm)	PXA domain-containing protein	0.0267	0.123	0.1215
Trypanosoma cruzi	NIMA-related kinase, putative	0.0052	0.0214	1
Entamoeba histolytica	hypothetical protein	0.0267	0.123	1
Echinococcus granulosus	dynamin 1	0.0046	0.0184	0.0176
Entamoeba histolytica	p21-activated kinase	0.0052	0.0214	0.029
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0046	0.0184	0.0176
Echinococcus multilocularis	regulator of G protein signaling	0.0267	0.123	0.1223
Loa Loa (eye worm)	cytohesin 3	0.0046	0.0184	0.0167
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0046	0.0184	0.0176
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Schistosoma mansoni	growth factor receptor-bound protein	0.0046	0.0184	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0485	0.2257	0.225
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0184	0.0176
Echinococcus granulosus	Pleckstrin y	0.0046	0.0184	0.0176
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0046	0.0184	0.0176
Leishmania major	serine/threonine-protein kinase a, putative	0.0052	0.0214	1
Trichomonas vaginalis	kinesin light chain, putative	0.0046	0.0184	0.1497
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0046	0.0184	0.0176
Echinococcus granulosus	beta 1 syntrophin	0.0046	0.0184	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0267	0.123	0.1215
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Echinococcus multilocularis	rac serine:threonine kinase	0.0052	0.0214	0.0206
Brugia malayi	PH domain containing protein	0.0046	0.0184	0.0478
Echinococcus granulosus	oxysterol binding protein 9	0.0046	0.0184	0.0176
Toxoplasma gondii	AtPH1 family protein	0.0046	0.0184	0.5189
Brugia malayi	PH domain containing protein	0.0046	0.0184	0.0478
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0135	0.0118
Trypanosoma brucei	protein kinase, putative	0.0052	0.0214	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0752	0.3519	0.3508
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0052	0.0214	1
Echinococcus multilocularis	dnaJ subfamily B	0.0431	0.2005	0.1998
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Trichomonas vaginalis	conserved hypothetical protein	0.0267	0.123	1
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0046	0.0184	0.0176
Schistosoma mansoni	syntrophin	0.0046	0.0184	0.0176
Trichomonas vaginalis	alpha chimerin, putative	0.0046	0.0184	0.1497
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0052	0.0214	0.7624
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0214	0.029
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Echinococcus multilocularis	muscleblind protein	0.0168	0.076	0.0752
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0119	0.0111
Schistosoma mansoni	regulator of G protein signaling	0.0267	0.123	0.1223
Brugia malayi	probable spectrin beta chain	0.0046	0.0184	0.0478
Echinococcus multilocularis	oxysterol binding protein 9	0.0046	0.0184	0.0176
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0052	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Echinococcus granulosus	serine/threonine protein kinase	0.0052	0.0214	0.0206
Echinococcus granulosus	regulator of G protein signaling 7	0.0267	0.123	0.1223
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0752	0.3519	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0119	0.0111
Schistosoma mansoni	oxysterol-binding protein 1	0.0046	0.0184	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0118
Echinococcus granulosus	expressed protein	0.0267	0.123	0.1223
Echinococcus multilocularis	regulator of G protein signaling 3	0.0267	0.123	0.1223
Schistosoma mansoni	hypothetical protein	0.0046	0.0184	0.0176
Brugia malayi	Muscleblind-like protein	0.0168	0.076	0.2122
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0046	0.0184	0.0167
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0267	0.123	0.3464
Trypanosoma cruzi	hypothetical protein	0.0046	0.0184	0.6162
Schistosoma mansoni	hypothetical protein	0.0017	0.0046	0.0038
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0052	0.0214	1
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0485	0.2257	0.225
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0216	0.0199
Echinococcus multilocularis	oxysterol binding protein 1	0.0046	0.0184	0.0176
Echinococcus granulosus	regulator of G protein signaling 3	0.0267	0.123	0.1223
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0046	0.0184	0.0176
Echinococcus granulosus	cytohesin 1	0.0046	0.0184	0.0176
Trypanosoma cruzi	hypothetical protein	0.0046	0.0184	0.6162
Loa Loa (eye worm)	uncoordinated protein 104	0.0046	0.0184	0.0167
Entamoeba histolytica	hypothetical protein	0.0267	0.123	1
Echinococcus granulosus	cpg binding protein	0.0032	0.0119	0.011
Onchocerca volvulus		0.0036	0.0135	0.0238
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0046	0.0084
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0214	0.029
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0046	0.0184	0.0176
Toxoplasma gondii	hypothetical protein	0.0046	0.0184	0.5189
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0046	0.0184	0.0176
Loa Loa (eye worm)	PH domain-containing protein	0.0046	0.0184	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Echinococcus multilocularis	axis inhibition protein axin	0.0267	0.123	0.1223
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Plasmodium vivax	hypothetical protein, conserved	0.0046	0.0184	0.6806
Schistosoma mansoni	hypothetical protein	0.0046	0.0184	0.0176
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0046	0.0184	0.0176
Echinococcus multilocularis	regulator of G protein signaling 7	0.0267	0.123	0.1223
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0052	0.0214	1
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0052	0.0214	1
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0046	0.0184	0.0706
Brugia malayi	beta-lactamase family protein	0.0036	0.0135	0.0339
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Onchocerca volvulus		0.0046	0.0184	0.0706
Echinococcus granulosus	DCC interacting protein 13 beta	0.0046	0.0184	0.0176
Toxoplasma gondii	hypothetical protein	0.0046	0.0184	0.5189
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0267	0.123	0.3464
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0181	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0168	0.076	0.0744
Schistosoma mansoni	regulator of G protein signaling	0.0267	0.123	0.1223
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0135	0.1101
Schistosoma mansoni	hypothetical protein	0.0046	0.0184	0.0176
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0181	0.0164
Echinococcus granulosus	GRB2 associated binding protein 3	0.0046	0.0184	0.0176
Echinococcus multilocularis	beta adrenergic receptor kinase	0.2124	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Trichomonas vaginalis	set domain proteins, putative	0.0251	0.1151	0.9356
Echinococcus granulosus	muscleblind protein	0.0168	0.076	0.0752
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.2124	1	1
Mycobacterium ulcerans	lipase LipD	0.0036	0.0135	0.5
Leishmania major	protein kinase, putative	0.0052	0.0214	1
Trichomonas vaginalis	centaurin gamma, putative	0.0046	0.0184	0.1497
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0046	0.0184	0.0176
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Brugia malayi	Dynamin	0.0046	0.0184	0.0478
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0052	0.0214	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0052	0.0214	0.0198
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0181	0.0172
Trypanosoma cruzi	Protein kinase B	0.0052	0.0214	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0214	0.029
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0118
Schistosoma mansoni	hypothetical protein	0.0046	0.0184	0.0176
Brugia malayi	beta-lactamase family protein	0.0036	0.0135	0.0339
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0046	0.0038
Entamoeba histolytica	protein kinase, putative	0.0052	0.0214	0.029
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0046	0.0184	0.0176
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0052	0.0214	0.1744
Echinococcus granulosus	Rho GTPase activating protein 24	0.0046	0.0184	0.0176
Leishmania major	protein kinase, putative	0.0052	0.0214	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0052	0.0214	1
Echinococcus granulosus	oxysterol binding protein 1	0.0046	0.0184	0.0176
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0017	0.0009
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0046	0.0184	0.0478
Loa Loa (eye worm)	rho-GTPase-activating	0.0046	0.0184	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0135	0.0339
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0046	0.0184	0.0176
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0046	0.0184	0.0167
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0184	0.6162
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0137	0.0344
Trichomonas vaginalis	hypothetical protein	0.0046	0.0184	0.1497
Onchocerca volvulus		0.0046	0.0184	0.0706
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0046	0.0184	0.6162
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0052	0.0214	0.1744
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0267	0.123	0.1223
Brugia malayi	A-kinase anchor protein 10, precursor	0.0267	0.123	0.3464
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0119	0.0102
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Schistosoma mansoni	regulator of G protein signaling	0.0267	0.123	0.1223
Brugia malayi	PXA domain containing protein	0.0267	0.123	0.3464
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0485	0.2257	0.2243
Entamoeba histolytica	protein kinase, putative	0.0052	0.0214	0.029
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0046	0.0184	0.0176
Entamoeba histolytica	hypothetical protein	0.0052	0.0214	0.029
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0135	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0135	0.0118
Echinococcus granulosus	Pleckstrin y	0.0046	0.0184	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.104	1
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Echinococcus multilocularis	Oxysterol binding protein 11	0.0046	0.0184	0.0176
Trichomonas vaginalis	conserved hypothetical protein	0.0267	0.123	1
Brugia malayi	PH domain containing protein	0.0046	0.0184	0.0478
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0046	0.0184	0.0167
Trichomonas vaginalis	centaurin beta, putative	0.0046	0.0184	0.1497
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0184	0.6162
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0046	0.0038
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0046	0.0184	0.5189
Brugia malayi	PH domain containing protein	0.0046	0.0184	0.0478
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Echinococcus multilocularis	regulator of G protein signaling 3	0.0267	0.123	0.1223
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0216	0.0569
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0184	0.1497
Loa Loa (eye worm)	hypothetical protein	0.0267	0.123	0.1215
Schistosoma mansoni	axis inhibition protein axin	0.0267	0.123	0.1223
Echinococcus multilocularis	cytohesin 1	0.0046	0.0184	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0267	0.123	0.1215
Onchocerca volvulus	Protein melted homolog	0.0046	0.0184	0.0706
Trichomonas vaginalis	conserved hypothetical protein	0.0267	0.123	1
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0267	0.123	0.1215
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0214	0.1744
Brugia malayi	hypothetical protein	0.0046	0.0184	0.0478
Entamoeba histolytica	hypothetical protein	0.0267	0.123	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0184	0.0167
Entamoeba histolytica	protein kinase, putative	0.0052	0.0214	0.029
Brugia malayi	PXA domain containing protein	0.0267	0.123	0.3464

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 7.6 umol/L	Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay	ChEMBL.	24012378

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24012378

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2442580

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1791640