TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 373.509 | Formula: C21H27NO3S
H donors: 1 H acceptors: 2 LogP: 4.55 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: CC(CC(=O)OC/C=C\CCNC(=O)/C=C/C=C/C=C/c1cccs1)C
InChi: 1S/C21H27NO3S/c1-18(2)17-21(24)25-15-9-5-8-14-22-20(23)13-7-4-3-6-11-19-12-10-16-26-19/h3-7,9-13,16,18H,8,14-15,17H2,1-2H3,(H,22,23)/b4-3+,9-5-,11-6+,13-7+
InChiKey: UXKHBPOYZOPFIH-MKAYIHSVSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Mus musculus	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References
Mus musculus	opioid receptor, delta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_139759	All targets in OG5_139759
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_139759	All targets in OG5_139759

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0292	0.11
Schistosoma mansoni	myotubularin-related protein	0.0035	0.0175	0.0165
Leishmania major	folate/biopterin transporter, putative	0.004	0.0203	1
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.004	0.0203	1
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0035	0.0175	0.0165
Echinococcus multilocularis	Pleckstrin y	0.0035	0.0175	0.0165
Onchocerca volvulus		0.0036	0.0183	0.1118
Onchocerca volvulus		0.0036	0.0183	0.1118
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0035	0.0175	0.1125
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.004	0.0203	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0183	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0183	0.5061
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0035	0.0175	0.0165
Schistosoma mansoni	regulator of G protein signaling	0.0189	0.1136	0.1127
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0189	0.1136	0.1127
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0062	0.0205
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Echinococcus granulosus	regulator of G protein signaling 3	0.0189	0.1136	0.1127
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.1136	0.7297
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.042	0.2575	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.004	0.0203	0.1307
Brugia malayi	Plekhf2 protein	0.0035	0.0175	0.0644
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Echinococcus multilocularis	cpg binding protein	0.0033	0.0161	0.0151
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0035	0.0175	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0183	0.0173
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0244	0.0913
Schistosoma mansoni	zinc finger protein	0.0035	0.0175	0.0165
Loa Loa (eye worm)	Plekhf2 protein	0.0035	0.0175	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0189	0.1136	0.1127
Schistosoma mansoni	hypothetical protein	0.0035	0.0175	0.0165
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1136	0.1127
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0035	0.0175	0.0165
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0035	0.0175	0.0165
Echinococcus granulosus	beta 1 syntrophin	0.0035	0.0175	0.0165
Brugia malayi	beta-lactamase	0.0036	0.0183	0.0674
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0035	0.0175	0.1068
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0035	0.0175	0.0165
Toxoplasma gondii	protein kinase domain-containing protein	0.004	0.0203	0.2488
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0189	0.1136	0.4389
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0292	0.0282
Mycobacterium ulcerans	lipase LipD	0.0036	0.0183	0.5
Entamoeba histolytica	hypothetical protein	0.0189	0.1136	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0189	0.1136	0.1127
Schistosoma mansoni	regulator of G protein signaling	0.0189	0.1136	0.1127
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0183	0.0173
Echinococcus multilocularis	beta 1 syntrophin	0.0035	0.0175	0.0165
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0244	0.0234
Echinococcus granulosus	Regulator of G protein signaling 20	0.0189	0.1136	0.1127
Brugia malayi	hypothetical protein	0.0189	0.1136	0.4389
Onchocerca volvulus		0.0035	0.0175	0.1068
Echinococcus multilocularis	regulator of G protein signaling 7	0.0189	0.1136	0.1127
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0183	0.0173
Brugia malayi	hypothetical protein	0.0189	0.1136	0.4389
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0244	0.0234
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0231	0.1395	0.1387
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0183	0.2696
Toxoplasma gondii	hypothetical protein	0.0035	0.0175	0.0805
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0183	0.5
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0035	0.0175	0.0165
Schistosoma mansoni	hypothetical protein	0.0035	0.0175	0.0165
Entamoeba histolytica	hypothetical protein	0.0189	0.1136	1
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0183	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1136	0.1127
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0162	0.0152
Echinococcus granulosus	axis inhibition protein axin	0.0189	0.1136	0.1127
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0035	0.0175	0.0165
Trichomonas vaginalis	hypothetical protein	0.0035	0.0175	0.1125
Schistosoma mansoni	oxysterol-binding protein 1	0.0035	0.0175	0.0165
Schistosoma mansoni	serine/threonine protein kinase	0.161	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0183	0.0173
Brugia malayi	PXA domain containing protein	0.0189	0.1136	0.4389
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0928	0.0919
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.161	1	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0161	0.0151
Leishmania major	protein kinase, putative	0.004	0.0203	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.004	0.0203	1
Loa Loa (eye worm)	rho-GTPase-activating	0.0035	0.0175	0.0165
Onchocerca volvulus		0.0035	0.0175	0.1068
Loa Loa (eye worm)	PH domain-containing protein	0.0035	0.0175	0.0165
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.004	0.0203	1
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Echinococcus multilocularis	Oxysterol binding protein 11	0.0035	0.0175	0.0165
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Schistosoma mansoni	hypothetical protein	0.0017	0.0062	0.0053
Entamoeba histolytica	hypothetical protein	0.004	0.0203	0.0295
Onchocerca volvulus		0.0035	0.0175	0.1068
Echinococcus granulosus	DCC interacting protein 13 beta	0.0035	0.0175	0.0165
Onchocerca volvulus		0.0036	0.0183	0.1118
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.004	0.0203	0.1307
Trichomonas vaginalis	set domain proteins, putative	0.0256	0.1556	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Loa Loa (eye worm)	RGS-3 protein	0.0189	0.1136	0.1127
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0644
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0035	0.0175	0.0165
Loa Loa (eye worm)	cytohesin 3	0.0035	0.0175	0.0165
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.004	0.0203	1
Schistosoma mansoni	serine/threonine-protein kinase	0.004	0.0203	0.0194
Leishmania major	hypothetical protein, conserved	0.0036	0.0183	0.2696
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0244	0.0234
Echinococcus multilocularis	muscleblind protein 1	0.0156	0.0928	0.0919
Echinococcus granulosus	regulator of G protein signaling 3	0.0189	0.1136	0.1127
Onchocerca volvulus		0.0031	0.015	0.0904
Echinococcus multilocularis	regulator of G protein signaling	0.0189	0.1136	0.1127
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.004	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0292	0.0282
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0035	0.0175	0.0165
Schistosoma mansoni	syntrophin	0.0035	0.0175	0.0165
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.015	0.014
Echinococcus multilocularis	dnaJ subfamily B	0.0442	0.2712	0.2705
Echinococcus multilocularis	pdz domain containing protein	0.0035	0.0175	0.0165
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0644
Brugia malayi	regulator of G-protein signaling egl-10	0.0189	0.1136	0.4389
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0189	0.1136	0.4389
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0035	0.0175	0.0165
Echinococcus multilocularis	regulator of G protein signaling 3	0.0189	0.1136	0.1127
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0183	0.2696
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0231	0.1395	0.1387
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0012	0.0002
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.004	0.0203	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.042	0.2575	0.2567
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.033	1
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.004	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Echinococcus granulosus	expressed protein	0.0189	0.1136	0.1127
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0183	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1136	0.1127
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.015	0.014
Brugia malayi	Oxysterol binding protein	0.0035	0.0175	0.0644
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0023	0.0014
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Onchocerca volvulus		0.0035	0.0175	0.1068
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0035	0.0175	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Trichomonas vaginalis	esterase, putative	0.0036	0.0183	0.1174
Echinococcus multilocularis	axis inhibition protein axin	0.0189	0.1136	0.1127
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Brugia malayi	Syntrophin-1	0.0035	0.0175	0.0644
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0035	0.0175	0.0165
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.004	0.0203	1
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0189	0.1136	0.1127
Trichomonas vaginalis	centaurin gamma, putative	0.0035	0.0175	0.1125
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0023	0.0014
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.004	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1136	0.1127
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0035	0.0175	0.1125
Brugia malayi	A-kinase anchor protein 10, precursor	0.0189	0.1136	0.4389
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0644
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0183	0.0173
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0232	0.1404	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0186	0.0686
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0162	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Brugia malayi	probable spectrin beta chain	0.0035	0.0175	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Entamoeba histolytica	p21-activated kinase	0.004	0.0203	0.0295
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0189	0.1136	0.1127
Echinococcus multilocularis	oxysterol binding protein 9	0.0035	0.0175	0.0165
Echinococcus granulosus	Oxysterol binding protein 11	0.0035	0.0175	0.0165
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1421	0.8821	0.8819
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0035	0.0175	0.0165
Schistosoma mansoni	hypothetical protein	0.0017	0.0062	0.0053
Schistosoma mansoni	hypothetical protein	0.0017	0.0062	0.0053
Schistosoma mansoni	oxysterol-binding protein 1	0.0035	0.0175	0.0165
Loa Loa (eye worm)	AGC/AKT protein kinase	0.004	0.0203	0.0194
Brugia malayi	TBC domain containing protein	0.0035	0.0175	0.0644
Echinococcus multilocularis	axis inhibition protein axin	0.0189	0.1136	0.1127
Echinococcus granulosus	axis inhibition protein axin	0.0189	0.1136	0.1127
Toxoplasma gondii	Oxysterol-binding protein	0.0035	0.0175	0.0805
Brugia malayi	beta-lactamase family protein	0.0036	0.0183	0.0674
Schistosoma mansoni	vav2	0.0035	0.0175	0.0165
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0062	0.0053
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0244	0.0234
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0175	0.3238
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.1136	0.7297
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0634	0.391	0.3904
Leishmania major	protein kinase, putative	0.004	0.0203	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Schistosoma mansoni	regulator of G protein signaling	0.0189	0.1136	0.1127
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Echinococcus multilocularis	expressed protein	0.0189	0.1136	0.1127
Brugia malayi	Variant SH3 domain containing protein	0.0035	0.0175	0.0644
Brugia malayi	Variant SH3 domain containing protein	0.0035	0.0175	0.0644
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0231	0.1395	0.1387
Loa Loa (eye worm)	syntrophin-1	0.0035	0.0175	0.0165
Schistosoma mansoni	goodpasture antigen-binding protein	0.0035	0.0175	0.0165
Echinococcus multilocularis	myotubularin protein 13	0.0035	0.0175	0.0165
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.004	0.0203	1
Echinococcus granulosus	dnaJ subfamily B	0.0442	0.2712	0.2705
Trypanosoma cruzi	Protein kinase B	0.004	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0183	0.0173
Plasmodium vivax	PH domain containing protein	0.0035	0.0175	0.3238
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0035	0.0175	0.0644
Brugia malayi	Dynamin	0.0035	0.0175	0.0644
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0035	0.0175	0.0165
Brugia malayi	Dynamin	0.0035	0.0175	0.0644
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0189	0.1136	0.1127
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.004	0.0203	1
Onchocerca volvulus	Putative zinc finger protein	0.0035	0.0175	0.1068
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0035	0.0175	0.3238
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0035	0.0175	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0244	0.0234
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Echinococcus granulosus	tm gpcr rhodopsin	0.0634	0.391	0.3904
Schistosoma mansoni	centaurin alpha	0.0035	0.0175	0.0165
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0183	0.1174
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0183	0.5
Echinococcus granulosus	cytohesin 1	0.0035	0.0175	0.0165
Brugia malayi	MAX-1A	0.0035	0.0175	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Trypanosoma brucei	rac serine-threonine kinase, putative	0.004	0.0203	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0183	0.0173
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Echinococcus granulosus	oxysterol binding protein 9	0.0035	0.0175	0.0165
Schistosoma mansoni	axis inhibition protein axin	0.0189	0.1136	0.1127
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0231	0.1395	0.1387
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0183	0.5
Trichomonas vaginalis	centaurin/arf, putative	0.0035	0.0175	0.1125
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0023	0.005
Schistosoma mansoni	hypothetical protein	0.0035	0.0175	0.0165
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0644
Echinococcus multilocularis	oxysterol binding protein 3	0.0035	0.0175	0.0165
Trypanosoma cruzi	NIMA-related kinase, putative	0.004	0.0203	1
Schistosoma mansoni	regulator of G protein signaling	0.0189	0.1136	0.1127
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0189	0.1136	0.7297
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1136	0.1127
Trichomonas vaginalis	centaurin/arf, putative	0.0035	0.0175	0.1125
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.0374	0.0364
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0162	0.0152
Echinococcus multilocularis	actin binding protein anillin	0.0035	0.0175	0.0165
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0035	0.0175	0.1125
Onchocerca volvulus	Protein melted homolog	0.0035	0.0175	0.1068
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0035	0.0175	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0644
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.1136	0.7297
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0035	0.0175	0.000000087705
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0644
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.1136	0.7297
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0183	0.5
Toxoplasma gondii	hypothetical protein	0.0035	0.0175	0.0805
Echinococcus granulosus	Pleckstrin y	0.0035	0.0175	0.0165
Trichomonas vaginalis	centaurin alpha, putative	0.0035	0.0175	0.1125
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0035	0.0175	0.0165
Brugia malayi	Pre-SET motif family protein	0.0033	0.0162	0.0591
Echinococcus multilocularis	cytohesin 1	0.0035	0.0175	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0062	0.0053
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.004	0.0203	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0244	0.0234
Schistosoma mansoni	dynamin	0.0035	0.0175	0.0165
Toxoplasma gondii	ABC1 family protein	0.0036	0.0183	0.1259
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0012	0.0002
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Schistosoma mansoni	zinc finger protein	0.0035	0.0175	0.0165
Echinococcus granulosus	Pleckstrin y	0.0035	0.0175	0.0165
Echinococcus granulosus	muscleblind protein	0.0156	0.0928	0.0919
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0186	0.0176
Loa Loa (eye worm)	PXA domain-containing protein	0.0189	0.1136	0.1127
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0012	0.0002
Schistosoma mansoni	hypothetical protein	0.0037	0.0186	0.0176
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0292	0.11
Onchocerca volvulus		0.0035	0.0175	0.1068
Echinococcus granulosus	regulator of G protein signaling 7	0.0189	0.1136	0.1127
Brugia malayi	regulator of G-protein signaling rgs-7	0.0189	0.1136	0.4389
Echinococcus granulosus	oxysterol binding protein 3	0.0035	0.0175	0.0165
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0035	0.0175	0.0165
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.004	0.0203	1
Schistosoma mansoni	dynamin	0.0035	0.0175	0.0165
Brugia malayi	CXXC zinc finger family protein	0.0031	0.015	0.0545
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.004	0.0203	1
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.004	0.0203	1
Schistosoma mansoni	cpg binding protein	0.0031	0.015	0.014
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0035	0.0175	0.0165
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Echinococcus multilocularis	muscleblind protein	0.0156	0.0928	0.0919
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0062	0.0053
Schistosoma mansoni	serine/threonine-protein kinase	0.004	0.0203	0.0194
Brugia malayi	Pre-SET motif family protein	0.0225	0.1363	0.5274
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0062	0.0053
Brugia malayi	beta-lactamase family protein	0.0036	0.0183	0.0674
Loa Loa (eye worm)	oxysterol binding protein	0.0035	0.0175	0.0165
Onchocerca volvulus		0.0035	0.0175	0.1068
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0183	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0062	0.0053
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Echinococcus granulosus	myotubularin protein 13	0.0035	0.0175	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0183	0.0173
Onchocerca volvulus		0.0256	0.1556	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0231	0.1395	0.5402
Trichomonas vaginalis	alpha chimerin, putative	0.0035	0.0175	0.1125
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Echinococcus granulosus	GRB2 associated binding protein 3	0.0035	0.0175	0.0165
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0062	0.0053
Entamoeba histolytica	hypothetical protein	0.0189	0.1136	1
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0189	0.1136	0.1127
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0244	0.0234
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0035	0.0175	0.1068
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.1136	0.7297
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.004	0.0203	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0035	0.0175	0.0165
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0162	0.0152
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1421	0.8821	0.8819
Schistosoma mansoni	hypothetical protein	0.0017	0.0062	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Schistosoma mansoni	serine/threonine protein kinase	0.161	1	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0162	0.0152
Echinococcus granulosus	oxysterol binding protein 1	0.0035	0.0175	0.0165
Echinococcus multilocularis	dynamin 1	0.0035	0.0175	0.0165
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0062	0.0053
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0183	0.0173
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0225	0.1363	0.1354
Echinococcus granulosus	pdz domain containing protein	0.0035	0.0175	0.0165
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0035	0.0175	0.0165
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0035	0.0175	0.0165
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0035	0.0175	0.0165
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0035	0.0175	0.1125
Brugia malayi	Oxysterol-binding protein	0.0035	0.0175	0.0644
Schistosoma mansoni	regulator of G protein signaling	0.0189	0.1136	0.1127
Echinococcus granulosus	serine/threonine protein kinase	0.004	0.0203	0.0194
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0189	0.1136	0.1127
Schistosoma mansoni	hypothetical protein	0.0442	0.2712	0.2705
Brugia malayi	Muscleblind-like protein	0.0156	0.0928	0.3581
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0035	0.0175	0.0644
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0062	0.0205
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0035	0.0175	0.1125
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Echinococcus multilocularis	oxysterol binding protein 1	0.0035	0.0175	0.0165
Schistosoma mansoni	axis inhibition protein axin	0.0189	0.1136	0.1127
Brugia malayi	Cadps2 protein	0.0035	0.0175	0.0644
Echinococcus multilocularis	regulator of G protein signaling 3	0.0189	0.1136	0.1127
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0183	0.0173
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Echinococcus granulosus	pleckstrin y domain containing family A	0.0035	0.0175	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0928	0.0919
Trichomonas vaginalis	protein transport protein sec7, putative	0.0035	0.0175	0.1125
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0035	0.0175	0.0165
Echinococcus granulosus	dynamin 1	0.0035	0.0175	0.0165
Trichomonas vaginalis	protein transport protein sec7, putative	0.0035	0.0175	0.1125
Entamoeba histolytica	hypothetical protein	0.004	0.0203	0.0295
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0035	0.0175	0.0644
Brugia malayi	PH domain containing protein	0.0035	0.0175	0.0644
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0162	0.0152
Echinococcus multilocularis	Pleckstrin y	0.0035	0.0175	0.0165
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0183	0.0173
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0183	0.1174
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Trichomonas vaginalis	kinesin light chain, putative	0.0035	0.0175	0.1125
Trypanosoma cruzi	NIMA-related kinase, putative	0.004	0.0203	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Brugia malayi	Protein kinase domain containing protein	0.004	0.0203	0.0755
Leishmania major	serine/threonine-protein kinase a, putative	0.004	0.0203	1
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0035	0.0175	0.0165
Schistosoma mansoni	goodpasture antigen-binding protein	0.0035	0.0175	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1136	0.1127
Trypanosoma brucei	protein kinase, putative	0.004	0.0203	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0012	0.0002
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Entamoeba histolytica	PH domain containing protein kinase, putative	0.004	0.0203	0.0295
Echinococcus granulosus	calcium dependent secretion activator 1	0.0035	0.0175	0.0165
Schistosoma mansoni	serine/threonine protein kinase	0.042	0.2575	0.2567
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.004	0.0203	0.2488
Echinococcus granulosus	Pleckstrin y	0.0035	0.0175	0.0165
Echinococcus granulosus	cpg binding protein	0.0033	0.0161	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0162	0.0152
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0012	0.0002
Brugia malayi	Cytohesin 3	0.0035	0.0175	0.0644
Onchocerca volvulus		0.0035	0.0175	0.1068
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0183	0.2696
Brugia malayi	Uncoordinated protein 104	0.0035	0.0175	0.0644
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0035	0.0175	0.0805
Loa Loa (eye worm)	uncoordinated protein 104	0.0035	0.0175	0.0165
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.1136	0.7297
Onchocerca volvulus	outspread protein homolog	0.0035	0.0175	0.1068
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0035	0.0175	0.0165
Schistosoma mansoni	growth factor receptor-bound protein	0.0035	0.0175	0.0165
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Schistosoma mansoni	z-protein (S1r protein)	0.0189	0.1136	0.1127
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0183	0.0674
Entamoeba histolytica	protein kinase, putative	0.004	0.0203	0.0295
Onchocerca volvulus		0.0033	0.0162	0.098
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Echinococcus multilocularis	regulator of G protein signaling 7	0.0189	0.1136	0.1127
Echinococcus multilocularis	rac serine:threonine kinase	0.004	0.0203	0.0194
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0035	0.0175	0.1125
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0035	0.0175	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0165
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0023	0.0014
Trichomonas vaginalis	centaurin beta, putative	0.0035	0.0175	0.1125
Toxoplasma gondii	AtPH1 family protein	0.0035	0.0175	0.0805
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0183	0.5
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0035	0.0175	0.0165
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Echinococcus multilocularis	Pleckstrin y	0.0035	0.0175	0.0165
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0183	0.1174
Brugia malayi	Pleckstrin Homology Domain	0.0035	0.0175	0.0644
Brugia malayi	hypothetical protein	0.0035	0.0175	0.0644
Brugia malayi	PXA domain containing protein	0.0189	0.1136	0.4389
Echinococcus granulosus	GPCR family 2	0.0017	0.0062	0.0053
Echinococcus granulosus	Rho GTPase activating protein 24	0.0035	0.0175	0.0165
Schistosoma mansoni	hypothetical protein	0.0035	0.0175	0.0165
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0244	0.0234
Trichomonas vaginalis	AGC family protein kinase	0.004	0.0203	0.1307
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0175	0.1125
Schistosoma mansoni	cpg binding protein	0.0033	0.0161	0.0151
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0035	0.0175	0.3238
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0035	0.0175	0.0165
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0162	0.0152
Schistosoma mansoni	rho gtpase activating protein	0.0035	0.0175	0.0165
Echinococcus multilocularis	beta adrenergic receptor kinase	0.161	1	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0175	0.0165

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 5.6 uM	Displacement of [3H]-CP-55940 from cannabinoid CB1 receptor in CD1 mouse brain membranes after 1 hr by liquid scintillation counting	ChEMBL.	24095014
Ki (binding)	= 10.2 uM	Displacement of [3H]-CP-55940 from cannabinoid CB2 receptor in CD1 mouse spleen membranes after 1 hr by liquid scintillation counting	ChEMBL.	24095014
Ki (binding)	= 11 uM	Displacement of [3H]DPDPE from delta opioid receptor in CD1 mouse brain membranes after 1 hr by liquid scintillation counting	ChEMBL.	24095014
Ki (binding)	= 41.5 uM	Displacement of [3H]DAMGO from mu opioid receptor in CD1 mouse brain membranes after 1 hr by liquid scintillation counting	ChEMBL.	24095014

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2442639

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1792063