Detailed information for compound 185038

Basic information

Technical information
  • TDR Targets ID: 185038
  • Name: (4-chlorophenyl) 2-[3-(trifluoromethyl)anilin o]benzoate
  • MW: 391.771 | Formula: C20H13ClF3NO2
  • H donors: 1 H acceptors: 1 LogP: 6.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F
  • InChi: 1S/C20H13ClF3NO2/c21-14-8-10-16(11-9-14)27-19(26)17-6-1-2-7-18(17)25-15-5-3-4-13(12-15)20(22,23)24/h1-12,25H
  • InChiKey: LAMMSASBDRKIMI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-(trifluoromethyl)anilino]benzoic acid (4-chlorophenyl) ester
  • (4-chlorophenyl) 2-[[3-(trifluoromethyl)phenyl]amino]benzoate
  • 2-[[3-(trifluoromethyl)phenyl]amino]benzoic acid (4-chlorophenyl) ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0663 0.2974 0.4553
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0434 0.2453
Schistosoma mansoni lamin 0.0109 0.0411 0.0628
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.001 0.001
Echinococcus multilocularis GA binding protein alpha chain 0.0146 0.0579 0.072
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0104 0.0388 0.305
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0104 0.0388 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0077 0.0094
Loa Loa (eye worm) hypothetical protein 0.0254 0.1079 0.165
Trichomonas vaginalis D-aminoacylase, putative 0.0342 0.1485 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0184 0.0279
Entamoeba histolytica hypothetical protein 0.0037 0.0077 0.0563
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0186 0.0764 0.1168
Echinococcus granulosus Endonuclease G 0.0399 0.1749 0.2181
Echinococcus granulosus zinc finger protein 0.0025 0.0022 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0342 0.1485 1
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0104 0.0388 0.0591
Plasmodium vivax hypothetical protein, conserved 0.0342 0.1485 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0114 0.0434 0.3421
Mycobacterium tuberculosis Conserved protein 0.0342 0.1485 0.115
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.015 0.0824
Brugia malayi MH1 domain containing protein 0.0051 0.0139 0.0213
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0002
Brugia malayi hypothetical protein 0.0236 0.0998 0.1528
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0663 0.2974 0.3711
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0018 0.0065
Echinococcus multilocularis smad 0.0051 0.0139 0.0172
Onchocerca volvulus 0.1432 0.653 1
Schistosoma mansoni hypothetical protein 0.008 0.0276 0.0421
Schistosoma mansoni ets 0.0021 0.0003 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0342 0.1485 0.8487
Mycobacterium leprae conserved hypothetical protein 0.0342 0.1485 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0038 0.0055
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0021 0.0003 0.0002
Echinococcus granulosus ETS transcription factor Elf 2 0.0021 0.0003 0.0001
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.015 0.0824
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.015 0.097
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0399 0.1749 1
Schistosoma mansoni hypothetical protein 0.0104 0.0388 0.0591
Onchocerca volvulus Huntingtin homolog 0.0246 0.1041 0.1592
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0043 0.021
Loa Loa (eye worm) hypothetical protein 0.0342 0.1485 0.2273
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0663 0.2974 0.3711
Echinococcus multilocularis musashi 0.0109 0.0411 0.0512
Schistosoma mansoni bromodomain containing protein 0.0074 0.0248 0.0378
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.1256 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.015 0.0228
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0688 0.4608
Schistosoma mansoni lamin 0.0109 0.0411 0.0628
Schistosoma mansoni microtubule-associated protein tau 0.1347 0.6135 0.9395
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0399 0.1749 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0258 0.1098 0.1682
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0998 0.1244
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0276 0.0423
Echinococcus multilocularis tar DNA binding protein 0.0196 0.0813 0.1014
Brugia malayi CXXC zinc finger family protein 0.006 0.0184 0.0281
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.015 0.097
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.0176 0.0268
Loa Loa (eye worm) hypothetical protein 0.0256 0.1091 0.1669
Echinococcus granulosus microtubule associated protein 2 0.1347 0.6135 0.7658
Brugia malayi beta-lactamase family protein 0.0342 0.1485 0.2274
Leishmania major importin beta-1 subunit, putative 0.0024 0.0017 0.0059
Schistosoma mansoni hypothetical protein 0.0858 0.3872 0.593
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0688 0.4608
Echinococcus multilocularis lamin 0.0109 0.0411 0.0512
Schistosoma mansoni hypothetical protein 0.0037 0.0077 0.0116
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0104 0.0388 0.0594
Brugia malayi Ets-domain containing protein 0.0146 0.0579 0.0886
Trypanosoma brucei protein kinase, putative 0.0053 0.015 0.0824
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.073 0.4893
Brugia malayi MH2 domain containing protein 0.0051 0.0139 0.0213
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0104 0.0388 0.305
Trypanosoma cruzi endonuclease G, putative 0.0399 0.1749 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0276 0.0343
Echinococcus granulosus tar DNA binding protein 0.0196 0.0813 0.1014
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0104 0.0388 0.0591
Echinococcus multilocularis ets variant gene 4 0.0021 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0319 0.1382 0.2115
Trichomonas vaginalis inositol monophosphatase, putative 0.0114 0.0434 0.289
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0663 0.2974 0.3711
Loa Loa (eye worm) RNA binding protein 0.0196 0.0813 0.1243
Schistosoma mansoni importin beta-1 0.003 0.0043 0.0064
Trypanosoma brucei endonuclease G, putative 0.0399 0.1749 1
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1098 0.7384
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0007 0.0011
Echinococcus multilocularis microtubule associated protein 2 0.1347 0.6135 0.7658
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0018 0.0298
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.035 0.0435
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0663 0.2974 0.4553
Schistosoma mansoni hypothetical protein 0.008 0.0276 0.0421
Onchocerca volvulus 0.0663 0.2974 0.4553
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0114 0.0434 0.0423
Onchocerca volvulus 0.0342 0.1485 0.2273
Echinococcus granulosus ETS domain containing protein Elk 1 0.0021 0.0003 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0342 0.1485 1
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.0707 0.1083
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0399 0.1749 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0342 0.1485 0.115
Schistosoma mansoni smad1 5 8 and 0.0051 0.0139 0.0211
Loa Loa (eye worm) hypothetical protein 0.0104 0.0388 0.0591
Brugia malayi hypothetical protein 0.0104 0.0388 0.0594
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0007 0.0007
Loa Loa (eye worm) fli-1 protein 0.0442 0.195 0.2984
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0688 0.4608
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0104 0.0388 0.0591
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0399 0.1749 1
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0663 0.2974 0.4554
Trichomonas vaginalis D-aminoacylase, putative 0.0342 0.1485 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0434 0.2453
Brugia malayi nuclear receptor NHR-88 0.0021 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.008 0.0276 0.0421
Schistosoma mansoni hypothetical protein 0.0186 0.0764 0.1168
Brugia malayi beta-lactamase 0.0342 0.1485 0.2274
Echinococcus granulosus dnaJ subfamily B 0.0858 0.3872 0.4833
Schistosoma mansoni cpg binding protein 0.0066 0.0209 0.0318
Loa Loa (eye worm) hypothetical protein 0.0104 0.0388 0.0591
Loa Loa (eye worm) hypothetical protein 0.0104 0.0388 0.0591
Leishmania major hypothetical protein, conserved 0.0342 0.1485 0.8487
Brugia malayi Intermediate filament tail domain containing protein 0.0109 0.0411 0.063
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0688 0.4608
Entamoeba histolytica hypothetical protein 0.0037 0.0077 0.0563
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.015 0.097
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0342 0.1485 0.2273
Entamoeba histolytica hypothetical protein 0.0037 0.0077 0.0563
Trichomonas vaginalis penicillin-binding protein, putative 0.0342 0.1485 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0434 0.2453
Schistosoma mansoni ran 0.0022 0.0007 0.0008
Schistosoma mansoni hypothetical protein 0.008 0.0276 0.0421
Loa Loa (eye worm) hypothetical protein 0.0342 0.1485 0.2273
Echinococcus multilocularis ETS transcription factor Elf 2 0.0021 0.0003 0.0001
Brugia malayi MH1 domain containing protein 0.0028 0.0035 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1098 0.7384
Brugia malayi RNA, U transporter 1 0.0085 0.0299 0.0457
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.001 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1098 0.7384
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0002 0.0002
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0663 0.2974 0.3711
Loa Loa (eye worm) hypothetical protein 0.0246 0.1041 0.1592
Onchocerca volvulus Huntingtin homolog 0.0246 0.1041 0.1592
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.0496 0.0757
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0043 0.021
Loa Loa (eye worm) hypothetical protein 0.0109 0.0411 0.0628
Trichomonas vaginalis esterase, putative 0.0342 0.1485 1
Schistosoma mansoni Smad4 0.0023 0.001 0.0012
Trypanosoma cruzi endonuclease G, putative 0.0399 0.1749 1
Schistosoma mansoni inositol monophosphatase 0.0114 0.0434 0.0663
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0002 0.0002
Brugia malayi Smad1 0.0051 0.0139 0.0213
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.015 0.0186
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0663 0.2974 0.3711
Loa Loa (eye worm) hypothetical protein 0.0173 0.0707 0.1081
Brugia malayi Ets-domain containing protein 0.0021 0.0003 0.0004
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.001 0.0012
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0688 0.1052
Echinococcus granulosus transferase 0.0104 0.0388 0.0482
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0038 0.0045
Schistosoma mansoni smad 0.0051 0.0139 0.0211
Echinococcus granulosus tumor protein p63 0.1752 0.801 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0276 0.0421
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0109 0.0411 0.0628
Mycobacterium tuberculosis Conserved protein 0.0342 0.1485 0.115
Echinococcus multilocularis tumor protein p63 0.1752 0.801 1
Mycobacterium leprae Probable lipase LipE 0.0342 0.1485 1
Echinococcus multilocularis ETS transcription factor Elf 2 0.0021 0.0003 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0254 0.1079 0.1652
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0104 0.0388 0.0482
Echinococcus granulosus smad 0.0051 0.0139 0.0172
Mycobacterium leprae hypothetical protein 0.0104 0.0388 0.0082
Brugia malayi Bromodomain containing protein 0.0087 0.0309 0.0473
Plasmodium falciparum importin beta, putative 0.003 0.0043 0.0959
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0002
Echinococcus granulosus geminin 0.0186 0.0764 0.0952
Loa Loa (eye worm) hypothetical protein 0.0236 0.0998 0.1526
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1098 0.7384
Loa Loa (eye worm) hypothetical protein 0.0246 0.1041 0.1592
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0002 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0017 0.007
Echinococcus granulosus GPCR family 2 0.008 0.0276 0.0343
Brugia malayi MH2 domain containing protein 0.0023 0.001 0.0015
Brugia malayi nuclear hormone receptor 0.0021 0.0002 0.0002
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0104 0.0388 0.0482
Schistosoma mansoni intermediate filament proteins 0.0109 0.0411 0.0628
Echinococcus granulosus lamin dm0 0.0109 0.0411 0.0512
Loa Loa (eye worm) MH2 domain-containing protein 0.0051 0.0139 0.0211
Mycobacterium ulcerans beta-lactamase 0.0342 0.1485 1
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0813 0.1243
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.073 0.4893
Schistosoma mansoni survival motor neuron protein 0.0048 0.0128 0.0194
Onchocerca volvulus 0.0342 0.1485 0.2273
Schistosoma mansoni ets-related 0.0021 0.0003 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0002 0.0002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0342 0.1485 0.1852
Brugia malayi ecdysteroid receptor 0.0021 0.0002 0.0002
Leishmania major endonuclease G, putative 0.0399 0.1749 1
Loa Loa (eye worm) transcription factor SMAD2 0.0743 0.3342 0.5117
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0663 0.2974 0.4553
Echinococcus multilocularis lamin dm0 0.0109 0.0411 0.0512
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0591 0.0902
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1256 0.8448
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1098 0.7384
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0276 0.0343
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0434 0.2453
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0104 0.0388 0.0482
Schistosoma mansoni zinc finger protein 0.0025 0.0022 0.0032
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0077 0.0094
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.1382 0.2115
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0559 0.2491 0.3109
Loa Loa (eye worm) MH1 domain-containing protein 0.0051 0.0139 0.0211
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.023 0.0285
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0104 0.0388 0.0591
Loa Loa (eye worm) hypothetical protein 0.0342 0.1485 0.2273
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0021 0.0003 0.0002
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0104 0.0388 0.0482
Brugia malayi intermediate filament protein 0.0109 0.0411 0.063
Echinococcus multilocularis mothers against decapentaplegic 5 0.0051 0.0139 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0688 0.4608
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0663 0.2974 0.4553
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.035 0.0533
Schistosoma mansoni cpg binding protein 0.006 0.0184 0.0279
Schistosoma mansoni smad 0.0023 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.008 0.0276 0.0421
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1256 0.8448
Echinococcus multilocularis zinc finger protein 0.0025 0.0022 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1256 0.8448
Onchocerca volvulus 0.0048 0.0128 0.0194
Loa Loa (eye worm) intermediate filament protein 0.0109 0.0411 0.0628
Echinococcus granulosus beta LACTamase domain containing family member 0.0342 0.1485 0.1852
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0104 0.0388 0.0482
Schistosoma mansoni smad1 5 8 and 0.0051 0.0139 0.0211
Echinococcus multilocularis ETS transcription factor Elf 1 0.0021 0.0003 0.0001
Brugia malayi beta-lactamase family protein 0.0342 0.1485 0.2274
Loa Loa (eye worm) hypothetical protein 0.0107 0.0402 0.0613
Echinococcus granulosus neuropeptide receptor A26 0.0481 0.2131 0.2659
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0342 0.1485 0.115
Toxoplasma gondii ABC1 family protein 0.0342 0.1485 0.8487
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0114 0.0434 0.289
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.035 0.0435
Loa Loa (eye worm) hypothetical protein 0.0342 0.1485 0.2273
Mycobacterium tuberculosis Probable esterase LipL 0.0342 0.1485 0.115
Trypanosoma brucei hypothetical protein, conserved 0.0342 0.1485 0.8487
Echinococcus granulosus inositol monophosphatase 1 0.0114 0.0434 0.054
Mycobacterium tuberculosis Conserved protein 0.0342 0.1485 0.115
Echinococcus granulosus ectonucleotide 0.0559 0.2491 0.3109
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0146 0.0579 0.0884
Echinococcus multilocularis ectonucleotide 0.0559 0.2491 0.3109
Loa Loa (eye worm) hypothetical protein 0.0104 0.0388 0.0591
Trypanosoma brucei endonuclease G, putative 0.0399 0.1749 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.015 0.0824
Echinococcus granulosus neuropeptide s receptor 0.0481 0.2131 0.2659
Onchocerca volvulus 0.0256 0.1091 0.1669
Loa Loa (eye worm) beta-lactamase 0.0342 0.1485 0.2273
Schistosoma mansoni hypothetical protein 0.0023 0.0012 0.0016
Echinococcus multilocularis snurportin 1 0.0319 0.1382 0.1724
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0017 0.007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0445 0.2516
Onchocerca volvulus 0.006 0.0184 0.0279
Echinococcus multilocularis importin subunit beta 1 0.003 0.0043 0.0052
Mycobacterium tuberculosis Probable hydrolase 0.0342 0.1485 0.115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.035 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0002 0.0002
Echinococcus granulosus ewsr:fli fusion protein type 0.0021 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0124 0.0481 0.0734
Schistosoma mansoni hypothetical protein 0.0104 0.0388 0.0591
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.035 0.0533
Brugia malayi Fli-1 protein 0.0442 0.195 0.2986
Echinococcus multilocularis cpg binding protein 0.0066 0.0209 0.0259
Brugia malayi Latrophilin receptor protein 2 0.008 0.0276 0.0423
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0017 0.0059
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0104 0.0388 0.0482
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.015 0.0186
Echinococcus multilocularis transferase 0.0104 0.0388 0.0482
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.0494 0.0615
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0077 0.0116
Schistosoma mansoni hypothetical protein 0.0104 0.0388 0.0591
Loa Loa (eye worm) ets-domain-containing protein 0.0021 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0025
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0114 0.0434 0.2453
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0104 0.0388 0.0591
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0663 0.2974 0.4553
Echinococcus granulosus ETS transcription factor Elf 5 0.0021 0.0003 0.0001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.015 0.0824
Plasmodium vivax importin-beta 2, putative 0.003 0.0043 0.0247
Brugia malayi MH2 domain containing protein 0.0051 0.0139 0.0213
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0051 0.014 0.0212
Schistosoma mansoni hypothetical protein 0.1432 0.653 1
Schistosoma mansoni hypothetical protein 0.0048 0.0128 0.0194
Loa Loa (eye worm) hypothetical protein 0.0051 0.014 0.0212
Mycobacterium ulcerans esterase/lipase LipP 0.0342 0.1485 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0023 0.001 0.0012
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0018 0.0077
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.0813 0.1246
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.015 0.0824
Echinococcus multilocularis neuropeptide s receptor 0.0481 0.2131 0.2659
Echinococcus granulosus snurportin 1 0.0319 0.1382 0.1724
Brugia malayi endonuclease G, mitochondrial precursor 0.0399 0.1749 0.2678
Echinococcus granulosus protein C ets 2 0.0021 0.0003 0.0001
Brugia malayi hypothetical protein 0.0024 0.0018 0.0028
Brugia malayi hypothetical protein 0.0037 0.0077 0.0118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0342 0.1485 0.2273
Echinococcus multilocularis dnaJ subfamily B 0.0858 0.3872 0.4833
Loa Loa (eye worm) hypothetical protein 0.0663 0.2974 0.4553
Leishmania major ethanolamine phosphotransferase, putative 0.0104 0.0388 0.2186
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.1256 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.035 0.0435
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0813 0.1243
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0104 0.0388 0.0482
Schistosoma mansoni Smad4 0.0051 0.0139 0.0211
Brugia malayi Inositol-1 0.0114 0.0434 0.0665
Schistosoma mansoni elf1 0.0021 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0103 0.0156
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0051 0.0139 0.0172
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0663 0.2974 0.3711
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.015 0.1149
Leishmania major hypothetical protein, conserved 0.0024 0.0018 0.0065
Echinococcus granulosus cpg binding protein 0.0066 0.0209 0.0259
Loa Loa (eye worm) hypothetical protein 0.0028 0.0035 0.005
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0064
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0254 0.1079 0.165
Brugia malayi Importin beta-1 subunit 0.003 0.0043 0.0066
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0998 0.1244
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0043 0.021
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0017 0.007
Loa Loa (eye worm) inositol-1 0.0114 0.0434 0.0663
Loa Loa (eye worm) hypothetical protein 0.0342 0.1485 0.2273
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0018 0.0065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0342 0.1485 0.2273
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0128 0.0196
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0051 0.0139 0.0211
Loa Loa (eye worm) hypothetical protein 0.0046 0.0116 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0813 0.1243
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1256 0.8448
Echinococcus multilocularis GPCR, family 2 0.008 0.0276 0.0343
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0813 0.1243
Schistosoma mansoni hypothetical protein 0.0173 0.0707 0.1081
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.015 0.0824
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.001 0.001
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.0494 0.0615
Schistosoma mansoni gabp alpha 0.0146 0.0579 0.0884
Brugia malayi transcription factor E74 isoform 0.0021 0.0003 0.0004
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0104 0.0388 0.0591
Entamoeba histolytica hypothetical protein 0.0037 0.0077 0.0563
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0018 0.0298
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0591 0.0902
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0688 0.4608
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0149 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0002 0.0002
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0012 0.0016
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0007 0.0007
Echinococcus granulosus importin subunit beta 1 0.003 0.0043 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0002 0.0002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0342 0.1485 0.2274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1256 0.8448
Echinococcus granulosus lamin 0.0109 0.0411 0.0512
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0258 0.1098 0.168
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0002 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0254 0.1079 0.1652
Echinococcus granulosus TGF beta signal transducer SmadC 0.0051 0.0139 0.0172
Loa Loa (eye worm) MH2 domain-containing protein 0.0743 0.3342 0.5117
Echinococcus granulosus GA binding protein alpha chain 0.0146 0.0579 0.072
Brugia malayi Ets-domain containing protein 0.0146 0.0579 0.0886
Schistosoma mansoni endonuclease related 0.0399 0.1749 0.2676
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0002 0.0002
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0021 0.0003 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0342 0.1485 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.035 0.0533
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.015 0.0824
Schistosoma mansoni ets-related 0.0442 0.195 0.2984
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.1256 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.015 0.0824
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.015 0.0186
Mycobacterium tuberculosis Probable lipase LipE 0.0342 0.1485 0.115
Brugia malayi RNA binding protein 0.0196 0.0813 0.1246
Loa Loa (eye worm) hypothetical protein 0.0079 0.0271 0.0412
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0002
Echinococcus granulosus ETS transcription factor Elf 1 0.0021 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0342 0.1485 0.2273
Schistosoma mansoni hypothetical protein 0.0104 0.0388 0.0591
Echinococcus multilocularis protein C ets 2 0.0021 0.0003 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0342 0.1485 0.8487
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.035 0.0533
Echinococcus granulosus mothers against decapentaplegic 5 0.0051 0.0139 0.0172
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0559 0.2491 0.3109
Loa Loa (eye worm) hypothetical protein 0.0053 0.0149 0.0226
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.0813 0.1243
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0002 0.0002
Brugia malayi TAR-binding protein 0.0196 0.0813 0.1246
Schistosoma mansoni ran 0.0022 0.0007 0.0008
Echinococcus multilocularis geminin 0.0186 0.0764 0.0952
Loa Loa (eye worm) hypothetical protein 0.0051 0.0141 0.0214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.1256 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0002 0.0002
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0114 0.0434 0.5
Brugia malayi MH2 domain containing protein 0.0743 0.3342 0.5118
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0663 0.2974 0.3711
Echinococcus multilocularis inositol monophosphatase 1 0.0114 0.0434 0.054
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0002
Onchocerca volvulus 0.0109 0.0411 0.0628
Brugia malayi hypothetical protein 0.0246 0.1041 0.1594
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0276 0.0343
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0565 0.1683
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.001 0.0012
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.015 0.0186
Brugia malayi Thrombospondin type 1 domain containing protein 0.1432 0.653 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0002 0.0002
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.001 0.001
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0104 0.0388 0.2186
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.1432 0.653 1
Schistosoma mansoni cellular tumor antigen P53 0.0256 0.1091 0.1669
Loa Loa (eye worm) nuclear factor I 0.0028 0.0035 0.005
Onchocerca volvulus 0.0342 0.1485 0.2273
Loa Loa (eye worm) hypothetical protein 0.0663 0.2974 0.4553
Loa Loa (eye worm) D-ets-2 protein 0.0021 0.0003 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.015 0.097
Loa Loa (eye worm) hypothetical protein 0.0559 0.2491 0.3814
Echinococcus multilocularis neuropeptide receptor A26 0.0481 0.2131 0.2659
Mycobacterium ulcerans hypothetical protein 0.0342 0.1485 1
Onchocerca volvulus 0.0663 0.2974 0.4553
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.035 0.0535
Schistosoma mansoni cpg binding protein 0.0066 0.0209 0.0318
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1256 0.8448
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.0591 0.0736
Brugia malayi MAP kinase sur-1 0.0053 0.015 0.023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1256 0.8448
Echinococcus granulosus intermediate filament protein 0.0109 0.0411 0.0512
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0565 0.1614
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0663 0.2974 0.3711
Trypanosoma brucei endonuclease G, putative 0.0399 0.1749 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0091 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0002 0.0002
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0565 0.0193
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0127 0.0494 0.0754
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0104 0.0388 0.0591
Brugia malayi MH1 domain containing protein 0.0051 0.0139 0.0213
Brugia malayi PHD-finger family protein 0.0031 0.005 0.0076
Loa Loa (eye worm) TAR-binding protein 0.0196 0.0813 0.1243
Brugia malayi DNA-binding protein D-ETS-3 0.0021 0.0003 0.0004
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0663 0.2974 0.3711
Mycobacterium tuberculosis Probable lipase LipD 0.0342 0.1485 0.115
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0149 0.0185
Mycobacterium ulcerans lipase LipD 0.0342 0.1485 1
Brugia malayi hypothetical protein 0.0104 0.0388 0.0594
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0007 0.0008
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0021 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.0024 0.0017 0.0083
Schistosoma mansoni smad1 5 8 and 0.0051 0.0139 0.0211
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.023 0.0285
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0688 0.4608
Onchocerca volvulus 0.0109 0.0411 0.0628
Echinococcus multilocularis Endonuclease G 0.0399 0.1749 0.2181
Echinococcus granulosus ETS transcription factor Elf 2 0.0021 0.0003 0.0001
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0663 0.2974 0.3711
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1256 0.8448
Echinococcus multilocularis ewsr:fli fusion protein type 0.0021 0.0003 0.0001
Brugia malayi Bromodomain containing protein 0.0043 0.0103 0.0158
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0114 0.0434 0.289
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.015 0.0228
Echinococcus multilocularis Smad4 0.0051 0.0139 0.0172
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0018 0.0065
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0276 0.0343
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0018 0.0065
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0104 0.0388 0.305
Loa Loa (eye worm) Smad1 0.0051 0.0139 0.0211
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0663 0.2974 0.3711
Brugia malayi AEL166Cp 0.0104 0.0388 0.0594
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0038 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0813 0.1243
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0342 0.1485 0.115
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0091 0.0111
Schistosoma mansoni inositol monophosphatase 0.0114 0.0434 0.0663
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1098 0.7384
Brugia malayi MH1 domain containing protein 0.0028 0.0035 0.0053
Echinococcus granulosus Smad4 0.0051 0.0139 0.0172
Schistosoma mansoni Smad4 0.0023 0.001 0.0012
Brugia malayi steroid hormone receptor 0.0021 0.0002 0.0002
Echinococcus multilocularis ETS transcription factor Elf 5 0.0021 0.0003 0.0001
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.0176 0.027

Activities

Activity type Activity value Assay description Source Reference
pGI50 (functional) NA 0 Antiproliferative activity against human leukemia K562 cell line ChEMBL. 16366606
pGI50 (functional) NA 0 Antiproliferative activity against human lung NCI-H23 cell line ChEMBL. 16366606
pGI50 (functional) NA 0 Antiproliferative activity against human colon SW620 cell line ChEMBL. 16366606
pGI50 (functional) NA 0 Antiproliferative activity against human CNS SF268 cell line ChEMBL. 16366606
pGI50 (functional) NA 0 Antiproliferative activity against human melanoma UACC62 cell line ChEMBL. 16366606
pGI50 (functional) NA 0 Antiproliferative activity against human renal SN12C cell line ChEMBL. 16366606
pGI50 (functional) NA 0 Antiproliferative activity against human breast cancer MCF7 cell line ChEMBL. 16366606

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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