Detailed information for compound 188550

Basic information

Technical information
  • TDR Targets ID: 188550
  • Name: 4-N-(2-methylphenyl)quinoline-3,4-diamine
  • MW: 249.31 | Formula: C16H15N3
  • H donors: 2 H acceptors: 1 LogP: 3.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1Nc1c(N)cnc2c1cccc2
  • InChi: 1S/C16H15N3/c1-11-6-2-4-8-14(11)19-16-12-7-3-5-9-15(12)18-10-13(16)17/h2-10H,17H2,1H3,(H,18,19)
  • InChiKey: ZXWXHEVMFPNCFA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N4-(o-tolyl)quinoline-3,4-diamine
  • N4-(2-methylphenyl)quinoline-3,4-diamine
  • (3-amino-4-quinolyl)-(o-tolyl)amine
  • N'-(2-methylphenyl)quinoline-3,4-diamine
  • (3-amino-4-quinolyl)-(2-methylphenyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cytohesin 1 0.0034 0.0174 0.0163
Echinococcus multilocularis expressed protein 0.0195 0.1219 0.1209
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.2655 0.2647
Trypanosoma brucei rac serine-threonine kinase, putative 0.0038 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Trichomonas vaginalis centaurin gamma, putative 0.0034 0.0174 0.1141
Brugia malayi Cadps2 protein 0.0034 0.0174 0.0437
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0162
Entamoeba histolytica ARF GTPase activating protein, putative 0.0034 0.0174 0.000000078896
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0038 0.0204 1
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Schistosoma mansoni serine/threonine protein kinase 0.0547 0.3496 0.3488
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0286 0.0759
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0034 0.0174 0.1141
Onchocerca volvulus Protein melted homolog 0.0034 0.0174 0.0199
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0038 0.0204 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Schistosoma mansoni rho gtpase activating protein 0.0034 0.0174 0.0163
Echinococcus multilocularis regulator of G protein signaling 3 0.0195 0.1219 0.1209
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0038 0.0204 0.134
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0038 0.0204 0.2792
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0547 0.3496 0.3481
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Brugia malayi probable spectrin beta chain 0.0034 0.0174 0.0437
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0034 0.0174 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Schistosoma mansoni myotubularin-related protein 0.0034 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Entamoeba histolytica p21-activated kinase 0.0038 0.0204 0.029
Loa Loa (eye worm) RGS-3 protein 0.0195 0.1219 0.1199
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Brugia malayi Pre-SET motif family protein 0.0213 0.1334 0.3777
Plasmodium vivax PH domain containing protein 0.0034 0.0174 0.3414
Loa Loa (eye worm) hypothetical protein 0.0195 0.1219 0.1199
Loa Loa (eye worm) uncoordinated protein 104 0.0034 0.0174 0.0151
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1357 0.8738 0.8736
Echinococcus granulosus dynamin 1 0.0034 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0195 0.1219 0.1199
Trichomonas vaginalis alpha chimerin, putative 0.0034 0.0174 0.1141
Schistosoma mansoni serine/threonine-protein kinase 0.0038 0.0204 0.0193
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0061 0.005
Toxoplasma gondii Oxysterol-binding protein 0.0034 0.0174 0.0953
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.005
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Brugia malayi Regulator of G protein signaling domain containing protein 0.0195 0.1219 0.3447
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0162
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0366 0.0355
Schistosoma mansoni goodpasture antigen-binding protein 0.0034 0.0174 0.0163
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0034 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0016 0.0061 0.0038
Echinococcus multilocularis Regulator of G protein signaling 20 0.0195 0.1219 0.1209
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Schistosoma mansoni z-protein (S1r protein) 0.0195 0.1219 0.1209
Leishmania major folate/biopterin transporter, putative 0.0038 0.0204 1
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0174 0.0437
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0195 0.1219 0.1209
Brugia malayi Syntrophin-1 0.0034 0.0174 0.0437
Brugia malayi Uncoordinated protein 104 0.0034 0.0174 0.0437
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0034 0.0174 0.0163
Entamoeba histolytica protein kinase, putative 0.0038 0.0204 0.029
Loa Loa (eye worm) hypothetical protein 0.0195 0.1219 0.1199
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0352 0.2233 0.2216
Onchocerca volvulus 0.0035 0.0185 0.028
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0158 0.0147
Trichomonas vaginalis esterase, putative 0.0035 0.0185 0.1214
Echinococcus granulosus serine/threonine protein kinase 0.0038 0.0204 0.0193
Trichomonas vaginalis centaurin alpha, putative 0.0034 0.0174 0.1141
Echinococcus multilocularis Oxysterol binding protein 11 0.0034 0.0174 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Trichomonas vaginalis kinesin light chain, putative 0.0034 0.0174 0.1141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0185 0.0174
Echinococcus granulosus GPCR family 2 0.0016 0.0061 0.005
Brugia malayi hypothetical protein 0.0195 0.1219 0.3447
Echinococcus multilocularis GRB2 associated binding protein 3 0.0034 0.0174 0.0163
Loa Loa (eye worm) syntrophin-1 0.0034 0.0174 0.0151
Echinococcus multilocularis regulator of G protein signaling 0.0195 0.1219 0.1209
Brugia malayi Dynamin 0.0034 0.0174 0.0437
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0038 0.0204 1
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0034 0.0174 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0204 0.029
Echinococcus multilocularis oxysterol binding protein 9 0.0034 0.0174 0.0163
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0034 0.0174 0.0437
Trypanosoma cruzi NIMA-related kinase, putative 0.0038 0.0204 1
Schistosoma mansoni hypothetical protein 0.0417 0.2655 0.2647
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0549 0.0539
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1334 0.1314
Loa Loa (eye worm) beta-lactamase 0.0035 0.0185 0.0162
Echinococcus multilocularis muscleblind protein 1 0.0158 0.0981 0.0971
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0034 0.0174 0.0151
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0038 0.0204 1
Schistosoma mansoni axis inhibition protein axin 0.0195 0.1219 0.1209
Echinococcus multilocularis Pleckstrin y 0.0034 0.0174 0.0163
Echinococcus granulosus muscleblind protein 0.0158 0.0981 0.0971
Echinococcus granulosus calcium dependent secretion activator 1 0.0034 0.0174 0.0163
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0038 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.1219 0.1199
Loa Loa (eye worm) rho-GTPase-activating 0.0034 0.0174 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0549 0.0539
Echinococcus multilocularis Pleckstrin y 0.0034 0.0174 0.0163
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0147 0.0136
Echinococcus granulosus regulator of G protein signaling 7 0.0195 0.1219 0.1209
Loa Loa (eye worm) hypothetical protein 0.0035 0.0182 0.0159
Trypanosoma brucei protein kinase, putative 0.0038 0.0204 1
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.1219 0.8002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Echinococcus granulosus regulator of G protein signaling 3 0.0195 0.1219 0.1209
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0061 0.005
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0547 0.3496 1
Brugia malayi Oxysterol-binding protein 0.0034 0.0174 0.0437
Onchocerca volvulus 0.0034 0.0174 0.0199
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0352 0.2233 0.2216
Echinococcus multilocularis rac serine:threonine kinase 0.0038 0.0204 0.0193
Brugia malayi Cytohesin 3 0.0034 0.0174 0.0437
Schistosoma mansoni regulator of G protein signaling 0.0195 0.1219 0.1209
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Schistosoma mansoni hypothetical protein 0.0035 0.0182 0.0171
Entamoeba histolytica hypothetical protein 0.0038 0.0204 0.029
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0034 0.0174 0.0151
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0038 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Trichomonas vaginalis protein transport protein sec7, putative 0.0034 0.0174 0.1141
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Loa Loa (eye worm) Plekhf2 protein 0.0034 0.0174 0.0151
Echinococcus multilocularis Pleckstrin y 0.0034 0.0174 0.0163
Brugia malayi PH domain containing protein 0.0034 0.0174 0.0437
Leishmania major serine/threonine-protein kinase a, putative 0.0038 0.0204 1
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Schistosoma mansoni syntrophin 0.0034 0.0174 0.0163
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0023 0.0012
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0204 0.029
Echinococcus multilocularis dynamin 1 0.0034 0.0174 0.0163
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0185 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.1552 1 1
Echinococcus multilocularis muscleblind protein 0.0158 0.0981 0.0971
Loa Loa (eye worm) hypothetical protein 0.0195 0.1219 0.1199
Brugia malayi Oxysterol binding protein 0.0034 0.0174 0.0437
Echinococcus multilocularis beta adrenergic receptor kinase 0.1552 1 1
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0034 0.0174 0.0163
Echinococcus multilocularis calcium dependent secretion activator 1 0.0034 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Trypanosoma cruzi NIMA-related kinase, putative 0.0038 0.0204 1
Schistosoma mansoni cpg binding protein 0.0031 0.0157 0.0146
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0038 0.0204 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0195 0.1219 0.3447
Echinococcus granulosus Pleckstrin y 0.0034 0.0174 0.0163
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0185 0.1214
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0034 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0158 0.0981 0.0961
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0158 0.0147
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0195 0.1219 0.1199
Brugia malayi TBC domain containing protein 0.0034 0.0174 0.0437
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0185 0.3681
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0162
Trichomonas vaginalis set domain proteins, putative 0.0242 0.1524 1
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0158 0.0147
Schistosoma mansoni regulator of G protein signaling 0.0195 0.1219 0.1209
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0185 0.1214
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0195 0.1219 0.1209
Echinococcus multilocularis DCC interacting protein 13 beta 0.0034 0.0174 0.0163
Schistosoma mansoni regulator of G protein signaling 0.0195 0.1219 0.1209
Mycobacterium ulcerans beta-lactamase 0.0035 0.0185 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0549 0.0539
Leishmania major hypothetical protein, conserved 0.0035 0.0185 0.3681
Echinococcus multilocularis regulator of G protein signaling 3 0.0195 0.1219 0.1209
Onchocerca volvulus 0.0034 0.0174 0.0199
Entamoeba histolytica protein kinase, putative 0.0038 0.0204 0.029
Brugia malayi regulator of G-protein signaling rgs-7 0.0195 0.1219 0.3447
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0286 0.0264
Brugia malayi hypothetical protein 0.0195 0.1219 0.3447
Schistosoma mansoni axis inhibition protein axin 0.0195 0.1219 0.1209
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0034 0.0174 0.0163
Brugia malayi PH domain containing protein 0.0034 0.0174 0.0437
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0286 0.0759
Brugia malayi PH domain containing protein 0.0034 0.0174 0.0437
Echinococcus multilocularis axis inhibition protein axin 0.0195 0.1219 0.1209
Echinococcus granulosus cpg binding protein 0.0031 0.0157 0.0146
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0034 0.0174 0.1141
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0163
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0182 0.046
Brugia malayi beta-lactamase 0.0035 0.0185 0.0469
Echinococcus multilocularis pdz domain containing protein 0.0034 0.0174 0.0163
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0034 0.0174 0.0163
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0038 0.0204 1
Brugia malayi regulator of G-protein signaling egl-10 0.0195 0.1219 0.3447
Trichomonas vaginalis centaurin beta, putative 0.0034 0.0174 0.1141
Onchocerca volvulus 0.0034 0.0174 0.0199
Echinococcus granulosus oxysterol binding protein 3 0.0034 0.0174 0.0163
Echinococcus multilocularis Ras associated and pleckstrin y 0.0034 0.0174 0.0163
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0195 0.1219 0.1209
Brugia malayi hypothetical protein 0.0034 0.0174 0.0437
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0185 0.5
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0034 0.0174 0.0163
Brugia malayi Pleckstrin Homology Domain 0.0034 0.0174 0.0437
Brugia malayi Dynamin 0.0034 0.0174 0.0437
Entamoeba histolytica hypothetical protein 0.0038 0.0204 0.029
Echinococcus granulosus expressed protein 0.0195 0.1219 0.1209
Loa Loa (eye worm) hypothetical protein 0.0031 0.0158 0.0136
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0038 0.0204 1
Brugia malayi beta-lactamase family protein 0.0035 0.0185 0.0469
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Loa Loa (eye worm) AGC/AKT protein kinase 0.0038 0.0204 0.0182
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0034 0.0174 0.0151
Echinococcus multilocularis regulator of G protein signaling 7 0.0195 0.1219 0.1209
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0352 0.2233 0.2225
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.1219 0.8002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0061 0.005
Entamoeba histolytica protein kinase, putative 0.0038 0.0204 0.029
Echinococcus multilocularis axis inhibition protein axin 0.0195 0.1219 0.1209
Schistosoma mansoni dynamin 0.0034 0.0174 0.0163
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0034 0.0174 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0549 0.0539
Leishmania major protein kinase, putative 0.0038 0.0204 1
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0038 0.0204 1
Onchocerca volvulus 0.0035 0.0185 0.028
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Onchocerca volvulus 0.0034 0.0174 0.0199
Toxoplasma gondii AtPH1 family protein 0.0034 0.0174 0.0953
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0158 0.0147
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0038 0.0204 1
Echinococcus granulosus oxysterol binding protein 9 0.0034 0.0174 0.0163
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0034 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0051 0.0286 0.0264
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.1552 1 1
Echinococcus granulosus Pleckstrin y 0.0034 0.0174 0.0163
Schistosoma mansoni centaurin alpha 0.0034 0.0174 0.0163
Onchocerca volvulus 0.0031 0.0158 0.0084
Echinococcus granulosus DCC interacting protein 13 beta 0.0034 0.0174 0.0163
Brugia malayi PH domain containing protein 0.0034 0.0174 0.0437
Echinococcus granulosus pdz domain containing protein 0.0034 0.0174 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.1219 0.8002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0061 0.0038
Toxoplasma gondii hypothetical protein 0.0034 0.0174 0.0953
Mycobacterium ulcerans hypothetical protein 0.0035 0.0185 0.5
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0034 0.0174 0.0437
Loa Loa (eye worm) cytohesin 3 0.0034 0.0174 0.0151
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0185 0.5
Echinococcus multilocularis beta 1 syntrophin 0.0034 0.0174 0.0163
Echinococcus multilocularis oxysterol binding protein 1 0.0034 0.0174 0.0163
Schistosoma mansoni oxysterol-binding protein 1 0.0034 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.1219 0.8002
Echinococcus multilocularis cytohesin 1 0.0034 0.0174 0.0163
Onchocerca volvulus 0.0034 0.0174 0.0199
Trichomonas vaginalis centaurin/arf, putative 0.0034 0.0174 0.1141
Echinococcus multilocularis myotubularin protein 13 0.0034 0.0174 0.0163
Onchocerca volvulus Putative zinc finger protein 0.0034 0.0174 0.0199
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0185 0.5838
Entamoeba histolytica protein kinase, putative 0.0038 0.0204 0.029
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0158 0.0147
Toxoplasma gondii phosphatidylinositol transfer protein 0.0034 0.0174 0.0953
Loa Loa (eye worm) hypothetical protein 0.0195 0.1219 0.1199
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0185 0.0469
Echinococcus multilocularis oxysterol binding protein 3 0.0034 0.0174 0.0163
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0034 0.0174 0.1141
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0204 0.029
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0174 0.3414
Entamoeba histolytica protein kinase, putative 0.0038 0.0204 0.029
Entamoeba histolytica hypothetical protein 0.0195 0.1219 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0204 0.029
Echinococcus granulosus myotubularin protein 13 0.0034 0.0174 0.0163
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0352 0.2233 0.2225
Schistosoma mansoni regulator of G protein signaling 0.0195 0.1219 0.1209
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Schistosoma mansoni cpg binding protein 0.0031 0.0157 0.0146
Brugia malayi CXXC zinc finger family protein 0.0029 0.0147 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Toxoplasma gondii protein kinase domain-containing protein 0.0038 0.0204 0.2792
Echinococcus granulosus GRB2 associated binding protein 3 0.0034 0.0174 0.0163
Brugia malayi PH domain containing protein 0.0034 0.0174 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0185 0.0162
Brugia malayi Pre-SET motif family protein 0.0031 0.0158 0.0391
Mycobacterium leprae Probable lipase LipE 0.0035 0.0185 0.5
Mycobacterium ulcerans lipase LipD 0.0035 0.0185 0.5
Echinococcus multilocularis pleckstrin y domain containing family A 0.0034 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0038 0.0204 1
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Schistosoma mansoni growth factor receptor-bound protein 0.0034 0.0174 0.0163
Brugia malayi Protein kinase domain containing protein 0.0038 0.0204 0.0524
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Loa Loa (eye worm) hypothetical protein 0.0158 0.0981 0.0961
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0034 0.0174 0.0163
Schistosoma mansoni zinc finger protein 0.0034 0.0174 0.0163
Schistosoma mansoni vav2 0.0034 0.0174 0.0163
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0034 0.0174 0.1141
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0185 0.1214
Brugia malayi PXA domain containing protein 0.0195 0.1219 0.3447
Brugia malayi PH domain containing protein 0.0034 0.0174 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Entamoeba histolytica protein kinase, putative 0.0038 0.0204 0.029
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0038 0.0204 0.134
Trichomonas vaginalis protein transport protein sec7, putative 0.0034 0.0174 0.1141
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0034 0.0174 0.0163
Trichomonas vaginalis centaurin/arf, putative 0.0034 0.0174 0.1141
Brugia malayi PXA domain containing protein 0.0195 0.1219 0.3447
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Echinococcus multilocularis Rho GTPase activating protein 24 0.0034 0.0174 0.0163
Brugia malayi Plekhf2 protein 0.0034 0.0174 0.0437
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Echinococcus granulosus pleckstrin y domain containing family A 0.0034 0.0174 0.0163
Echinococcus multilocularis actin binding protein anillin 0.0034 0.0174 0.0163
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0061 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0162
Echinococcus multilocularis GPCR, family 2 0.0016 0.0061 0.005
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0034 0.0174 0.1141
Echinococcus granulosus dnaJ subfamily B 0.0417 0.2655 0.2647
Brugia malayi MAX-1A 0.0034 0.0174 0.0437
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0549 0.0539
Echinococcus granulosus axis inhibition protein axin 0.0195 0.1219 0.1209
Brugia malayi PH domain containing protein 0.0034 0.0174 0.0437
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0034 0.0174 0.0199
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Schistosoma mansoni regulator of G protein signaling 0.0195 0.1219 0.1209
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0204 0.029
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0195 0.1219 0.1209
Entamoeba histolytica hypothetical protein 0.0195 0.1219 1
Echinococcus granulosus axis inhibition protein axin 0.0195 0.1219 0.1209
Echinococcus granulosus Regulator of G protein signaling 20 0.0195 0.1219 0.1209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0549 0.0539
Onchocerca volvulus 0.0034 0.0174 0.0199
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0034 0.0174 0.0163
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0185 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Schistosoma mansoni serine/threonine-protein kinase 0.0038 0.0204 0.0193
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0034 0.0174 0.1141
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1414 1
Schistosoma mansoni oxysterol-binding protein 1 0.0034 0.0174 0.0163
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.005
Echinococcus multilocularis cpg binding protein 0.0031 0.0157 0.0146
Onchocerca volvulus 0.0034 0.0174 0.0199
Schistosoma mansoni serine/threonine protein kinase 0.1552 1 1
Entamoeba histolytica protein kinase, putative 0.0038 0.0204 0.029
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0158 0.0147
Echinococcus granulosus Rho GTPase activating protein 24 0.0034 0.0174 0.0163
Echinococcus granulosus G protein coupled receptor kinase 1 0.1357 0.8738 0.8736
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0034 0.0174 0.0163
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0185 0.1214
Echinococcus granulosus regulator of G protein signaling 7 0.0195 0.1219 0.1209
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0162
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0061 0.005
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0352 0.2233 0.6366
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0061 0.0112
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0163
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0185 0.0174
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0038 0.0204 1
Schistosoma mansoni cpg binding protein 0.0029 0.0147 0.0135
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0038 0.0204 1
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0034 0.0174 0.0199
Entamoeba histolytica hypothetical protein 0.0195 0.1219 1
Echinococcus granulosus Oxysterol binding protein 11 0.0034 0.0174 0.0163
Echinococcus granulosus Pleckstrin y 0.0034 0.0174 0.0163
Leishmania major protein kinase, putative 0.0038 0.0204 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0204 0.029
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0034 0.0174 0.0163
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0023 0.0012
Brugia malayi Muscleblind-like protein 0.0158 0.0981 0.2762
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0549 0.0528
Trypanosoma cruzi Protein kinase B 0.0038 0.0204 1
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0034 0.0174 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0034 0.0174 0.0163
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0549 0.1518
Onchocerca volvulus outspread protein homolog 0.0034 0.0174 0.0199
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0034 0.0174 0.3414
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.1219 0.8002
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0185 0.1214
Loa Loa (eye worm) PXA domain-containing protein 0.0195 0.1219 0.1199
Toxoplasma gondii ABC1 family protein 0.0035 0.0185 0.163
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0158 0.0147
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.005
Schistosoma mansoni dynamin 0.0034 0.0174 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0163
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0185 0.3681
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Plasmodium falciparum calcium-dependent protein kinase 7 0.0038 0.0204 1
Brugia malayi PH domain containing protein 0.0034 0.0174 0.0437
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0323 1
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0034 0.0174 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.1219 0.8002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Trichomonas vaginalis hypothetical protein 0.0034 0.0174 0.1141
Echinococcus granulosus beta 1 syntrophin 0.0034 0.0174 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0034 0.0174 0.0151
Loa Loa (eye worm) PH domain-containing protein 0.0034 0.0174 0.0151
Toxoplasma gondii hypothetical protein 0.0034 0.0174 0.0953
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Schistosoma mansoni zinc finger protein 0.0034 0.0174 0.0163
Brugia malayi beta-lactamase family protein 0.0035 0.0185 0.0469
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0195 0.1219 0.1209
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0034 0.0174 0.0163
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0038 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0174 0.0151
Brugia malayi A-kinase anchor protein 10, precursor 0.0195 0.1219 0.3447
Brugia malayi PH domain containing protein 0.0034 0.0174 0.0437
Echinococcus granulosus oxysterol binding protein 1 0.0034 0.0174 0.0163
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0034 0.0174 0.3414
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0147 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0549 0.0539
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0034 0.0174 0.0163
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0195 0.1219 0.8002
Echinococcus multilocularis regulator of G protein signaling 7 0.0195 0.1219 0.1209
Loa Loa (eye worm) oxysterol binding protein 0.0034 0.0174 0.0151
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0174 0.0437
Schistosoma mansoni hypothetical protein 0.0034 0.0174 0.0163
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0038 0.0204 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0174 0.1141
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0185 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0185 0.0162
Schistosoma mansoni goodpasture antigen-binding protein 0.0034 0.0174 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0204 0.134
Onchocerca volvulus 0.0035 0.0185 0.028
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0185 0.3681
Onchocerca volvulus 0.0242 0.1524 1
Echinococcus granulosus regulator of G protein signaling 3 0.0195 0.1219 0.1209

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 30.6 uM Concentration required to inhibit the activity of K+ stimulated gastric ATPase ChEMBL. 1326634
Inhibition (functional) = 27 % Inhibition of pentagastrin stimulated gastric acid secretion in anesthetized rat at 10 umol/kg upon intravenous administration ChEMBL. 1326634

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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