Detailed information for compound 1910186

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1232.77 | Formula: C57H78ClN15O14
  • H donors: 15 H acceptors: 13 LogP: 0.3 Rotable bonds: 44
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)CCCNC(=N)N)CC(C)C)Cc1ccc(cc1)O)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)OCc1ccccc1)CCC(=O)N.Cl
  • InChi: 1S/C57H77N15O14.ClH/c1-32(2)24-41(51(80)67-40(14-8-22-62-56(60)61)55(84)72-23-9-15-45(72)54(83)64-28-47(59)76)66-48(77)29-65-49(78)42(25-33-16-18-36(74)19-17-33)68-53(82)44(30-73)70-52(81)43(26-35-27-63-38-13-7-6-12-37(35)38)69-50(79)39(20-21-46(58)75)71-57(85)86-31-34-10-4-3-5-11-34;/h3-7,10-13,16-19,27,32,39-45,63,73-74H,8-9,14-15,20-26,28-31H2,1-2H3,(H2,58,75)(H2,59,76)(H,64,83)(H,65,78)(H,66,77)(H,67,80)(H,68,82)(H,69,79)(H,70,81)(H,71,85)(H4,60,61,62);1H/t39-,40-,41-,42-,43-,44-,45-;/m0./s1
  • InChiKey: FETFKLMVXDWTPD-RKTASIGASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.001 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.001 0.0016
Trypanosoma brucei polo-like protein kinase 0.0073 0.0263 0.3182
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0051 0.0176 0.0493
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0057 0.0057
Brugia malayi Dopamine receptor protein 2 0.002 0.0057 0.0085
Brugia malayi hypothetical protein 0.0017 0.0047 0.007
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0054 0.0188 0.0283
Echinococcus granulosus Niemann Pick C1 protein 0.0413 0.1574 0.1574
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.0067 0.0866
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.0035 0.0094
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Schistosoma mansoni hypothetical protein 0.0035 0.0116 0.0298
Echinococcus multilocularis serotonin receptor 0.002 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0715 0.2736 0.4118
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0054 0.0188 0.1282
Brugia malayi DKFZp564C0469 protein 0.0033 0.0106 0.016
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0057 0.0057
Brugia malayi cytochrome P450 0.0014 0.0035 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0057 0.0057
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0199 0.0747 0.1125
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0056
Trypanosoma cruzi protein farnesyltransferase, putative 0.0199 0.0747 0.909
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0035 0.0403
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0057 0.0057
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0199 0.0747 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0074 0.0265 0.3531
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0038 0.0127 0.0127
Schistosoma mansoni nuclear hormone receptor 0.0008 0.001 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0106 0.1398
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Trypanosoma cruzi lanosterol synthase, putative 0.0218 0.0822 1
Echinococcus granulosus allatostatin A receptor 0.002 0.0057 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0057 0.0146
Brugia malayi hypothetical protein 0.002 0.0057 0.0085
Echinococcus granulosus replication factor c subunit 1 0.0033 0.0106 0.0106
Echinococcus granulosus muscleblind protein 0.0131 0.0484 0.0484
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Schistosoma mansoni cytochrome P450 0.0014 0.0035 0.0091
Brugia malayi hypothetical protein 0.0025 0.0077 0.0115
Chlamydia trachomatis DNA ligase 0.0033 0.0106 1
Loa Loa (eye worm) BEN-1 protein 0.0022 0.0067 0.01
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.001 0.001
Brugia malayi hypothetical protein 0.002 0.0057 0.0085
Brugia malayi hypothetical protein 0.002 0.0057 0.0085
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0019 0.0052 0.06
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0056 0.0162
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0015 0.0037 0.0104
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0035 0.0099
Brugia malayi steroid hormone receptor 0.0008 0.001 0.0016
Echinococcus multilocularis allatostatin A receptor 0.002 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus granulosus tubulin beta 1 chain 0.0022 0.0067 0.0067
Entamoeba histolytica acyl-CoA synthetase, putative 0.002 0.0056 0.0343
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0382 0.1451 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0015 0.0037 0.0239
Loa Loa (eye worm) hypothetical protein 0.0131 0.0484 0.0729
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.012 0.1586
Brugia malayi serine/threonine-protein kinase plk-2 0.0073 0.0263 0.0396
Schistosoma mansoni hypothetical protein 0.0171 0.0639 0.1645
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0054 0.0188 0.2498
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0057 0.0057
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0054 0.0188 0.0484
Entamoeba histolytica acyl-CoA synthetase, putative 0.002 0.0056 0.0343
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0054 0.0188 0.1182
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0077 0.0914
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0057 0.0057
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0073 0.0263 0.0396
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0057 0.0085
Trypanosoma cruzi FHA domain containing protein, putative 0.0033 0.0106 0.1266
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0057 0.0146
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0033 0.0106 0.1398
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0054 0.0188 0.2498
Schistosoma mansoni lipoxygenase 0.0072 0.0258 0.0664
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0199 0.0747 1
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0035 0.0403
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0057 0.0057
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0057 0.0146
Brugia malayi hypothetical protein 0.002 0.0057 0.0085
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0057 0.0057
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0057 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.001 0.0016
Brugia malayi Niemann-Pick C1 protein precursor 0.0413 0.1574 0.2369
Echinococcus multilocularis dnaJ subfamily B 0.0358 0.136 0.136
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Entamoeba histolytica hypothetical protein 0.0035 0.0116 0.0721
Echinococcus granulosus hypothetical protein 0.002 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0035 0.0116 0.0721
Brugia malayi nuclear hormone receptor 0.0008 0.001 0.0016
Echinococcus granulosus snurportin 1 0.0269 0.1019 0.1019
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.002 0.0057 0.0089
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0033 0.005
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0074 0.0265 0.3206
Brugia malayi G protein-coupled receptor 0.002 0.0057 0.0085
Trichomonas vaginalis importin beta-1, putative 0.002 0.0059 0.0764
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0038 0.0127 0.0127
Brugia malayi AKH receptor 0.002 0.0057 0.0085
Leishmania major beta tubulin 0.0022 0.0067 0.086
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0085
Onchocerca volvulus 0.002 0.0057 0.0089
Loa Loa (eye worm) patched family protein 0.0025 0.0077 0.0115
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0044 0.0148 0.0223
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.001 0.0027
Echinococcus granulosus beta tubulin 0.0022 0.0067 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0002 0.0004
Giardia lamblia Rab geranylgeranyltransferase 0.0074 0.0265 0.307
Brugia malayi Doublecortin family protein 0.0017 0.0047 0.007
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0035 0.0099
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0074 0.0265 0.3206
Echinococcus multilocularis serotonin receptor 0.002 0.0057 0.0057
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0014 0.0035 0.0099
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.001 0.0015
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0006 0.0002 0.0004
Echinococcus multilocularis conserved hypothetical protein 0.0326 0.1237 0.1237
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0263 0.0677
Toxoplasma gondii patched family protein 0.0025 0.0077 0.0512
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0016
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0057 0.0085
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0035 0.0099
Loa Loa (eye worm) oxidoreductase 0.0006 0.0002 0.0004
Brugia malayi GnHR receptor homolog 0.0352 0.1335 0.201
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0033 0.005
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0006 0.0004 0.0004
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0199 0.0747 0.5142
Echinococcus multilocularis protein dispatched 1 0.0203 0.0761 0.0761
Schistosoma mansoni hypothetical protein 0.0171 0.0639 0.1645
Schistosoma mansoni hypothetical protein 0.0171 0.0639 0.1645
Echinococcus granulosus lipoxygenase domain containing protein 0.0017 0.0047 0.0047
Echinococcus granulosus importin subunit beta 1 0.0025 0.0077 0.0077
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0054 0.0188 0.0283
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0199 0.0747 0.0747
Echinococcus multilocularis importin subunit beta 1 0.0025 0.0077 0.0077
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0074 0.0265 0.1814
Loa Loa (eye worm) doublecortin family protein 0.0017 0.0047 0.007
Echinococcus granulosus survival motor neuron protein 1 0.0598 0.2285 0.2285
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0057 0.0146
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0057 0.0057
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Leishmania major geranylgeranyltransferase, putative 0.0054 0.0188 0.2493
Schistosoma mansoni cpg binding protein 0.0027 0.0082 0.0212
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0116 0.0116
Toxoplasma gondii hypothetical protein 0.0382 0.1451 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0022 0.0067 0.0866
Echinococcus granulosus sterol regulatory element binding protein 0.0177 0.0664 0.0664
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0122 0.045 0.0678
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0074 0.0265 0.0265
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0019 0.0052 0.0078
Loa Loa (eye worm) hypothetical protein 0.0715 0.2736 0.4118
Echinococcus granulosus neuropeptide receptor 0.002 0.0057 0.0057
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Onchocerca volvulus 0.0025 0.0077 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0265 0.3206
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0006 0.0002 0.0002
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0074 0.0265 0.0399
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0056
Leishmania major importin beta-1 subunit, putative 0.002 0.0059 0.0758
Brugia malayi Matrixin family protein 0.1729 0.6643 1
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0067 0.0067
Onchocerca volvulus 0.0025 0.0077 0.0122
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0051 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Brugia malayi follicle stimulating hormone receptor 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.001 0.0016
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.001 0.0027
Echinococcus multilocularis lipoxygenase domain containing protein 0.0017 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0358 0.136 0.3499
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.0035 0.0094
Echinococcus multilocularis cpg binding protein 0.0027 0.0082 0.0082
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0199 0.0747 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0035 0.0099
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0057 0.0085
Plasmodium vivax replication factor C subunit 1, putative 0.0033 0.0106 0.0716
Schistosoma mansoni opsin-like receptor 0.002 0.0057 0.0146
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0051 0.0176 0.0176
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0057 0.0146
Toxoplasma gondii hypothetical protein 0.0025 0.0077 0.0512
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.001 0.001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0074 0.0265 0.0682
Leishmania major cytochrome p450-like protein 0.0014 0.0035 0.0443
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Schistosoma mansoni hypothetical protein 0.002 0.0057 0.0146
Onchocerca volvulus 0.0025 0.0077 0.0122
Brugia malayi Cytochrome P450 family protein 0.0076 0.0273 0.0411
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0035 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0057 0.0057
Toxoplasma gondii beta-tubulin, putative 0.0022 0.0067 0.0442
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0057 0.0057
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0057 0.0057
Brugia malayi hypothetical protein 0.0025 0.0077 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.012 0.1586
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0019 0.0052 0.0052
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0074 0.0265 0.0265
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0074 0.0265 0.0265
Trypanosoma brucei beta tubulin 0.0022 0.0067 0.0782
Brugia malayi Matrixin family protein 0.0715 0.2736 0.4118
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.2599 1 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0073 0.0263 0.0428
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0057 0.0057
Brugia malayi topoisomerase 0.0033 0.0106 0.016
Loa Loa (eye worm) patched family protein 0.0025 0.0077 0.0115
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.001 0.001
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0006 0.0002 0.0002
Giardia lamblia Replication factor C, subunit 1 0.0033 0.0106 0.0784
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0057 0.0057
Schistosoma mansoni myosin xvIII 0.002 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0086
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0176 0.0519
Schistosoma mansoni hypothetical protein 0.0017 0.0047 0.012
Echinococcus granulosus serotonin receptor 0.002 0.0057 0.0057
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0056 0.0162
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0176 0.0452
Echinococcus multilocularis survival motor neuron protein 1 0.0598 0.2285 0.2285
Giardia lamblia Kinase, PLK 0.0073 0.0263 0.3041
Leishmania major beta tubulin 0.0022 0.0067 0.086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.009
Echinococcus multilocularis 0.0014 0.0035 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.0035 0.0094
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.007
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.0035 0.0094
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0057 0.0085
Leishmania major cytochrome p450-like protein 0.0014 0.0035 0.0443
Plasmodium vivax hypothetical protein, conserved 0.0382 0.1451 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0033 0.0106 0.1398
Echinococcus multilocularis neuropeptide s receptor 0.0404 0.1539 0.1539
Leishmania major beta tubulin 0.0022 0.0067 0.086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0127 0.0328
Brugia malayi hypothetical protein 0.002 0.0057 0.0085
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0057 0.0057
Trypanosoma cruzi polo-like protein kinase, putative 0.0073 0.0263 0.3182
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.009
Brugia malayi Patched related family protein 4 0.0025 0.0077 0.0115
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0057 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0188 0.2267
Giardia lamblia Rab geranylgeranyltransferase 0.0074 0.0265 0.307
Brugia malayi Myosin head containing protein 0.0025 0.0077 0.0115
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Onchocerca volvulus Matrix metalloproteinase homolog 0.1586 0.6092 1
Onchocerca volvulus 0.002 0.0057 0.0089
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0535 0.2042 0.5252
Onchocerca volvulus 0.002 0.0057 0.0089
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0035 0.0403
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0106 0.1266
Schistosoma mansoni hypothetical protein 0.0269 0.1019 0.2621
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0057 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.0035 0.0094
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0057 0.0057
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.001 0.0016
Giardia lamblia Beta tubulin 0.0022 0.0067 0.0214
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0056 0.0162
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.009
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0002 0.0004
Brugia malayi G-protein coupled receptor 0.002 0.0057 0.0085
Echinococcus multilocularis g protein coupled receptor 0.002 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0217 0.0818 0.1231
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0057 0.0085
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0051 0.0176 0.2325
Plasmodium falciparum importin beta, putative 0.0025 0.0077 0.1005
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.001 0.001
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0054 0.0188 0.2493
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0074 0.0265 0.1672
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0073 0.0263 0.0263
Toxoplasma gondii patched family protein 0.0025 0.0077 0.0512
Onchocerca volvulus 0.002 0.0057 0.0089
Schistosoma mansoni cpg binding protein 0.0027 0.0082 0.0212
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0871 0.3337 0.9494
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0116
Echinococcus multilocularis replication factor c subunit 1 0.0033 0.0106 0.0106
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0116 0.0298
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0057 0.0146
Echinococcus granulosus GTP binding nuclear protein Ran 0.0019 0.0052 0.0052
Schistosoma mansoni patched 1 0.0177 0.0664 0.1708
Loa Loa (eye worm) hypothetical protein 0.0598 0.2285 0.3439
Brugia malayi hypothetical protein 0.0598 0.2285 0.3439
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Leishmania major beta tubulin 0.0022 0.0067 0.086
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.002 0.0056 0.0154
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0057 0.0057
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0074 0.0265 0.3206
Toxoplasma gondii beta tubulin 0.0022 0.0067 0.0442
Onchocerca volvulus Bile acid receptor homolog 0.0008 0.001 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0106 0.1398
Loa Loa (eye worm) tubulin beta-1 chain 0.0022 0.0067 0.01
Brugia malayi Melatonin receptor type 1A 0.002 0.0057 0.0085
Toxoplasma gondii hypothetical protein 0.0074 0.0265 0.1814
Onchocerca volvulus 0.0025 0.0077 0.0122
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0054 0.0188 0.0484
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0057 0.0146
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.001 0.0027
Toxoplasma gondii ATPase, AAA family protein 0.0033 0.0106 0.0716
Schistosoma mansoni amine GPCR 0.002 0.0057 0.0146
Echinococcus granulosus beta tubulin 0.0022 0.0067 0.0067
Toxoplasma gondii HEAT repeat-containing protein 0.0025 0.0077 0.0517
Trypanosoma cruzi importin beta-1 subunit, putative 0.002 0.0059 0.0689
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0035 0.0228
Loa Loa (eye worm) hypothetical protein 0.0043 0.0147 0.0221
Schistosoma mansoni loxhd1 0.0017 0.0047 0.012
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0074 0.0265 0.0682
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0283
Echinococcus granulosus nibrin 0.0033 0.0106 0.0106
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0054 0.0188 0.2267
Schistosoma mansoni cpg binding protein 0.0025 0.0077 0.0198
Echinococcus granulosus g protein coupled receptor 0.002 0.0057 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.0035 0.0094
Echinococcus multilocularis tubulin subunit beta 0.0022 0.0067 0.0067
Echinococcus multilocularis neuropeptide receptor A26 0.0404 0.1539 0.1539
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0057 0.0057
Echinococcus granulosus neuropeptide s receptor 0.0404 0.1539 0.1539
Echinococcus granulosus orexin receptor type 2 0.002 0.0057 0.0057
Leishmania major cytochrome p450-like protein 0.0014 0.0035 0.0443
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0074 0.0265 0.3531
Brugia malayi Tubulin beta-1 chain 0.0022 0.0067 0.01
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0035 0.0099
Brugia malayi hypothetical protein 0.0033 0.0106 0.016
Echinococcus multilocularis fmrfamide receptor 0.002 0.0057 0.0057
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.001 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0002 0.0004
Brugia malayi Patched related family protein 10 0.0025 0.0077 0.0115
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0073 0.0263 0.0263
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.001 0.0027
Trypanosoma cruzi lanosterol synthase, putative 0.0218 0.0822 1
Leishmania major beta tubulin 0.0022 0.0067 0.086
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0038 0.0127 0.0127
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0057 0.0085
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0056 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0263 0.3505
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0067 0.0067
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0067 0.0067
Schistosoma mansoni coup transcription factor 0.0008 0.001 0.0027
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0074 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.1014 0.3888 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0017 0.0047 0.0047
Brugia malayi RNA, U transporter 1 0.0072 0.0257 0.0386
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.016
Brugia malayi hypothetical protein 0.0025 0.0077 0.0115
Brugia malayi AMP-binding enzyme family protein 0.002 0.0056 0.0085
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0073 0.0263 0.3501
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0056 0.0162
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0074 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0014 0.0035 0.0091
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0056 0.0724
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0038 0.0127 0.0192
Brugia malayi ORL1-like opioid receptor 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Trichomonas vaginalis antibiotic synthetase, putative 0.0006 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0086
Echinococcus multilocularis neuropeptide receptor 0.002 0.0057 0.0057
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0035 0.0099
Trypanosoma cruzi protein farnesyltransferase, putative 0.0199 0.0747 0.909
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.0035 0.0094
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0057 0.0057
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0057 0.0085
Echinococcus granulosus Protein patched homolog 1 0.0177 0.0664 0.0664
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0057 0.0057
Schistosoma mansoni lipoxygenase 0.0103 0.0378 0.0972
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.0035 0.0094
Schistosoma mansoni tubulin subunit beta 0.0022 0.0067 0.0171
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.002 0.0056 0.0162
Echinococcus multilocularis protein patched 0.0177 0.0664 0.0664
Echinococcus granulosus sex peptide receptor 0.002 0.0057 0.0057
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0057 0.0085
Onchocerca volvulus 0.0025 0.0077 0.0122
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.001 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Loa Loa (eye worm) BEN-1 protein 0.0022 0.0067 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0176 0.0519
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0067 0.0067
Brugia malayi hypothetical protein 0.002 0.0057 0.0085
Echinococcus multilocularis somatostatin receptor 0.002 0.0057 0.0057
Schistosoma mansoni neuropeptide receptor 0.002 0.0057 0.0146
Schistosoma mansoni histamine h1 receptor 0.002 0.0057 0.0146
Onchocerca volvulus 0.002 0.0057 0.0089
Brugia malayi Patched protein homolog 1 0.0025 0.0077 0.0115
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1986 0.7635 0.7635
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus multilocularis lipoxygenase domain containing protein 0.0017 0.0047 0.0047
Schistosoma mansoni DNA ligase IV 0.0033 0.0106 0.0273
Onchocerca volvulus 0.002 0.0056 0.0089
Brugia malayi ecdysteroid receptor 0.0008 0.001 0.0016
Schistosoma mansoni tubulin subunit beta 0.0022 0.0067 0.0171
Loa Loa (eye worm) cytochrome P450 0.0014 0.0035 0.0053
Onchocerca volvulus 0.0008 0.001 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.0035 0.0094
Echinococcus granulosus tyrosine protein kinase Lyn 0.0005 0.0001 0.0001
Echinococcus multilocularis fmrfamide receptor 0.002 0.0057 0.0057
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0035 0.0099
Echinococcus granulosus g protein coupled receptor 0.002 0.0057 0.0057
Toxoplasma gondii beta-1 tubulin, putative 0.0022 0.0067 0.0442
Echinococcus granulosus RUN 0.0017 0.0047 0.0047
Echinococcus granulosus Niemann Pick C1 protein 0.0591 0.2258 0.2258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0057 0.0146
Plasmodium falciparum geranylgeranyltransferase, putative 0.0054 0.0188 0.2493
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0199 0.0747 0.0747
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0095 0.0143
Trichomonas vaginalis ran, putative 0.0019 0.0052 0.0666
Echinococcus multilocularis Niemann Pick C1 protein 0.0591 0.2258 0.2258
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0199 0.0747 0.909
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0054 0.0188 0.1182
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.002 0.0056 0.0162
Echinococcus multilocularis sex peptide receptor 0.002 0.0057 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0057 0.0146
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0057 0.0146
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0057 0.0085
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0199 0.0747 0.1922
Loa Loa (eye worm) beta-tubulin 0.0022 0.0067 0.01
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0038 0.0128 0.0192
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Schistosoma mansoni hypothetical protein 0.002 0.0057 0.0146
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0054 0.0188 0.0283
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0074 0.0265 0.1814
Entamoeba histolytica tubulin family protein 0.0022 0.0067 0.0408
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0057 0.0057
Echinococcus granulosus tumor protein p63 0.0296 0.112 0.112
Schistosoma mansoni survival motor neuron protein 0.0122 0.045 0.1158
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0035 0.0053
Brugia malayi putative neuropeptide receptor 0.002 0.0057 0.0085
Brugia malayi nuclear receptor NHR-88 0.0008 0.001 0.0016
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0035 0.0053
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0054 0.0188 0.2267
Loa Loa (eye worm) hypothetical protein 0.0715 0.2736 0.4118
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.001 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0057 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0263 0.3505
Mycobacterium ulcerans hydrolase 0.0871 0.3337 1
Schistosoma mansoni amine GPCR 0.002 0.0057 0.0146
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0057 0.0057
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Entamoeba histolytica Ran family GTPase 0.0019 0.0052 0.0313
Onchocerca volvulus 0.0025 0.0077 0.0122
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0871 0.3337 0.5022
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0033 0.0106 0.1266
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.0164 0.1113
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0057 0.0057
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0035 0.0099
Schistosoma mansoni tubulin subunit beta 0.0022 0.0067 0.0171
Loa Loa (eye worm) tubulin beta chain 0.0022 0.0067 0.01
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Brugia malayi Importin beta-1 subunit 0.0025 0.0077 0.0116
Schistosoma mansoni rab6-interacting 0.0017 0.0047 0.012
Echinococcus granulosus FTZ F1 alpha 0.0008 0.001 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0004 0.0004
Loa Loa (eye worm) matrixin family protein 0.1729 0.6643 1
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0074 0.0265 0.0265
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0002 0.0004
Trypanosoma brucei beta tubulin 0.0022 0.0067 0.0782
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0035 0.0443
Schistosoma mansoni amine GPCR 0.002 0.0057 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.001 0.0016
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0067 0.0866
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0057 0.0057
Schistosoma mansoni niemann-pick C1 (NPC1) 0.042 0.1599 0.4112
Echinococcus multilocularis muscleblind protein 1 0.0131 0.0484 0.0484
Onchocerca volvulus 0.0017 0.0047 0.0072
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0199 0.0747 0.5142
Brugia malayi Serotonin receptor 0.002 0.0057 0.0085
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0054 0.0188 0.0188
Echinococcus multilocularis Polycystic kidney disease protein 0.0017 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Brugia malayi neuropeptide F receptor 0.002 0.0057 0.0085
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0033 0.005
Leishmania major beta tubulin 0.0022 0.0067 0.086
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0035 0.0403
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0035 0.0403
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0057 0.0057
Brugia malayi neuropeptide F receptor 0.002 0.0057 0.0085
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0067 0.0067
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.0035 0.0099
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.0035 0.0094
Plasmodium falciparum replication factor C subunit 1, putative 0.0033 0.0106 0.1393
Schistosoma mansoni importin beta-1 0.0025 0.0077 0.0199
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.0035 0.0094
Trypanosoma brucei beta tubulin 0.0022 0.0067 0.0782
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0019 0.0052 0.034
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0004 0.0004
Onchocerca volvulus 0.002 0.0057 0.0089
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0033 0.0106 0.0716
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0086
Brugia malayi Cytochrome P450 family protein 0.0014 0.0035 0.0053
Brugia malayi hypothetical protein 0.002 0.0057 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0106 0.1398
Brugia malayi G-protein coupled receptor 0.002 0.0057 0.0085
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0218 0.0822 0.2333
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0057 0.0057
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0057 0.0057
Echinococcus granulosus neuropeptide receptor A26 0.0404 0.1539 0.1539
Plasmodium falciparum LCCL domain-containing protein 0.0017 0.0047 0.0592
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.001 0.0016
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Loa Loa (eye worm) tubulin beta-4 chain 0.0022 0.0067 0.01
Brugia malayi RE15519p 0.002 0.0057 0.0085
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0074 0.0265 0.0399
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0067 0.0067
Plasmodium vivax geranylgeranyltransferase, putative 0.0054 0.0188 0.1282
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0283
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0016
Schistosoma mansoni rab6-interacting 0.0017 0.0047 0.012
Brugia malayi hypothetical protein 0.0017 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0016
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.002 0.0056 0.0162
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.0035 0.0094
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0022 0.0067 0.0067
Plasmodium vivax multidomain scavenger receptor, putative 0.0017 0.0047 0.0304
Brugia malayi hypothetical protein 0.002 0.0057 0.0085
Echinococcus granulosus Polycystic kidney disease protein 0.0017 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.001 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.001 0.0016
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.001 0.0016
Toxoplasma gondii patched family protein 0.0025 0.0077 0.0512
Echinococcus granulosus GPCR family 2 0.0014 0.0033 0.0033
Echinococcus granulosus dnaJ subfamily B 0.0358 0.136 0.136
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Schistosoma mansoni tubulin subunit beta 0.0022 0.0067 0.0171
Brugia malayi Patched related family protein 12 0.0025 0.0077 0.0115
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0033 0.0106 0.016
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0056 0.0724
Brugia malayi hypothetical protein 0.002 0.0057 0.0085
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0074 0.0265 0.3206
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0057 0.0085
Brugia malayi Dopamine receptor 0.002 0.0057 0.0085
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0033 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0057 0.0146
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0033 0.0106 0.1266
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0106 0.1266
Echinococcus multilocularis muscleblind protein 0.0131 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0035 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0054 0.0188 0.2498
Echinococcus multilocularis snurportin 1 0.0269 0.1019 0.1019
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0057 0.0085
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0057 0.0146
Plasmodium vivax importin-beta 2, putative 0.0025 0.0077 0.0517
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0054 0.0188 0.1282
Schistosoma mansoni thyroid hormone receptor 0.0008 0.001 0.0027
Brugia malayi CHE-14 protein 0.0177 0.0664 0.1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0006 0.0002 0.0004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.001 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0263 0.3505
Giardia lamblia Rab geranylgeranyltransferase 0.0054 0.0188 0.1963
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0176 0.0519
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.016
Treponema pallidum DNA ligase (lig) 0.0033 0.0106 0.5
Mycobacterium leprae putative cytochrome p450 0.0014 0.0035 0.0099
Brugia malayi Muscleblind-like protein 0.0131 0.0484 0.0729
Onchocerca volvulus 0.002 0.0057 0.0089
Brugia malayi sulfakinin receptor protein 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0145 0.0539 0.3705
Onchocerca volvulus 0.002 0.0057 0.0089
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0057 0.0085
Brugia malayi Calcitonin receptor-like protein seb-1 0.0044 0.0148 0.0223
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0035 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.001 0.0016
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0033 0.0106 0.066
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0035 0.0099
Entamoeba histolytica serine/threonine protein kinase, putative 0.0073 0.0263 0.1659
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0103 0.0378 0.0378
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0057 0.0057
Brugia malayi hypothetical protein 0.0025 0.0077 0.0115
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.0035 0.0094
Trypanosoma cruzi polo-like protein kinase, putative 0.0073 0.0263 0.3182
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0057 0.0057
Plasmodium vivax patched family protein, putative 0.0025 0.0077 0.0512
Onchocerca volvulus 0.0122 0.045 0.0735
Leishmania major beta tubulin 0.0022 0.0067 0.086
Schistosoma mansoni hypothetical protein 0.0171 0.0639 0.1645
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Loa Loa (eye worm) patched family protein 0.0025 0.0077 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0263 0.3505
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0106 0.1398
Leishmania major farnesyltransferase beta subunit 0.0199 0.0747 1
Trypanosoma brucei beta tubulin 0.0022 0.0067 0.0782
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus multilocularis expressed conserved protein 0.0388 0.1477 0.1477
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0057 0.0057
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0177 0.0664 0.1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0035 0.0099
Onchocerca volvulus 0.0017 0.0047 0.0072
Toxoplasma gondii patched family protein 0.0025 0.0077 0.0512
Loa Loa (eye worm) hypothetical protein 0.0413 0.1574 0.2369
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0199 0.0747 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0103 0.0378 0.0378
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0008 0.001 0.0013
Schistosoma mansoni hypothetical protein 0.002 0.0057 0.0146
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0074 0.0265 0.3206
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.0035 0.0094
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0057 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.0035 0.0094
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0015 0.0037 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.016
Onchocerca volvulus 0.0715 0.2736 0.4488
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0035 0.0099
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0269 0.1019 0.1534
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0057 0.0146
Giardia lamblia Beta tubulin 0.0022 0.0067 0.0214
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0035 0.0403
Onchocerca volvulus 0.002 0.0057 0.0089
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0057 0.0146
Toxoplasma gondii aldehyde dehydrogenase 0.0051 0.0176 0.1195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.001 0.001
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0057 0.0146
Brugia malayi hypothetical protein 0.002 0.0057 0.0085
Loa Loa (eye worm) follicle stimulating hormone receptor 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.016
Brugia malayi protein C24B5.3 0.0025 0.0077 0.0115
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Schistosoma mansoni adenoreceptor 0.002 0.0057 0.0146
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0199 0.0747 0.1125
Schistosoma mansoni opsin-like receptor 0.002 0.0057 0.0146
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.005
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0054 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0057 0.0057
Onchocerca volvulus 0.002 0.0057 0.0089
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0057 0.0057
Schistosoma mansoni neuropeptide receptor 0.002 0.0057 0.0146
Echinococcus granulosus mixed lineage leukemia protein mll 0.0006 0.0004 0.0004
Echinococcus multilocularis g protein coupled receptor 0.002 0.0057 0.0057
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0057 0.0057
Plasmodium falciparum acyl-CoA synthetase 0.0015 0.0037 0.0465
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0044 0.0148 0.0223
Schistosoma mansoni growth factor receptor-bound protein 0.0038 0.0128 0.0329
Schistosoma mansoni biogenic amine receptor 0.002 0.0057 0.0146
Echinococcus granulosus somatostatin receptor 0.002 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.0035 0.0094
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Onchocerca volvulus Neuropeptide F receptor homolog 0.002 0.0057 0.0089
Brugia malayi larval opioid receptor 0.002 0.0057 0.0085
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0067 0.0067
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0033 0.0106 0.1398
Leishmania major beta tubulin 0.0022 0.0067 0.086
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0035 0.0035
Onchocerca volvulus Protein patched homolog 0.0025 0.0077 0.0122
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0057 0.0057
Loa Loa (eye worm) matrixin family protein 0.1586 0.6092 0.9171
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0057 0.0057
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0033 0.0106 0.0311
Onchocerca volvulus 0.002 0.0057 0.0089
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0077 0.0116
Onchocerca volvulus Matrilysin homolog 0.1586 0.6092 1
Schistosoma mansoni thyroid hormone receptor 0.0008 0.001 0.0027
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0074 0.0265 0.3206
Echinococcus multilocularis g protein coupled receptor 0.002 0.0057 0.0057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0116 0.0116
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0057 0.0057
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.0067 0.0866
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0006 0.0002 0.0004
Echinococcus multilocularis Niemann Pick C1 protein 0.0413 0.1574 0.1574
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0057 0.0146
Echinococcus multilocularis RUN 0.0017 0.0047 0.0047
Leishmania major lanosterol synthase, putative 0.0164 0.0614 0.8206
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0035 0.0403
Schistosoma mansoni cellular tumor antigen P53 0.0043 0.0147 0.0378
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0057 0.0085
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0074 0.0265 0.3527
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0057 0.0057
Echinococcus multilocularis tumor protein p63 0.0296 0.112 0.112
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0715 0.2736 0.7038
Loa Loa (eye worm) hypothetical protein 0.0074 0.0265 0.0399
Schistosoma mansoni acetyl-CoA synthetase 0.0006 0.0002 0.0006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0057 0.0146
Leishmania major beta tubulin 0.0022 0.0067 0.086
Entamoeba histolytica hypothetical protein 0.0033 0.0106 0.066
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0057 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0057 0.0057
Schistosoma mansoni ran 0.0019 0.0052 0.0133
Giardia lamblia Beta tubulin 0.0022 0.0067 0.0214
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.0035 0.0094
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Schistosoma mansoni ran 0.0019 0.0052 0.0133
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0056
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0035 0.0099
Trichomonas vaginalis tubulin, putative 0.0022 0.0067 0.0866
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0056
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0059 0.0764
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0035 0.0099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0004 0.0011
Onchocerca volvulus 0.0033 0.0106 0.017
Onchocerca volvulus 0.0025 0.0077 0.0122
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.001 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0033 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0127 0.0328
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0016
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.001 0.0016
Brugia malayi Matrixin family protein 0.0715 0.2736 0.4118
Plasmodium vivax tubulin beta chain, putative 0.0022 0.0067 0.0442
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.001 0.0016
Echinococcus multilocularis GPCR, family 2 0.0014 0.0033 0.0033
Entamoeba histolytica hypothetical protein 0.002 0.0059 0.0359
Leishmania major GTP-binding protein, putative 0.0019 0.0052 0.066
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Onchocerca volvulus 0.002 0.0057 0.0089
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0057 0.0085
Brugia malayi Serotonin receptor 0.002 0.0057 0.0085
Loa Loa (eye worm) matrix metalloproteinase 0.0715 0.2736 0.4118
Trichomonas vaginalis antibiotic synthetase, putative 0.0006 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Onchocerca volvulus 0.002 0.0057 0.0089
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0016
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.001 0.001
Brugia malayi hypothetical protein 0.0035 0.0116 0.0174
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0199 0.0747 0.474
Echinococcus granulosus tubulin subunit beta 0.0022 0.0067 0.0067
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0035 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0057 0.0057
Echinococcus granulosus expressed conserved protein 0.0388 0.1477 0.1477
Schistosoma mansoni biogenic amine receptor 0.002 0.0057 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0664 0.8883
Schistosoma mansoni amine GPCR 0.002 0.0057 0.0146
Onchocerca volvulus 0.0043 0.0147 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0057 0.0085
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0057 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0263 0.3505
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.001 0.0027
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0016
Echinococcus granulosus g protein coupled receptor 0.002 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.003 0.0095 0.0244
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0057 0.0057
Onchocerca volvulus 0.002 0.0057 0.0089
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.001 0.0027
Echinococcus granulosus neuropeptide receptor 0.002 0.0057 0.0057
Echinococcus multilocularis orexin receptor type 2 0.002 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0131 0.0484 0.0729
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Entamoeba histolytica tubulin family protein 0.0022 0.0067 0.0408
Mycobacterium leprae PROBABLE HYDROLASE 0.0871 0.3337 1
Schistosoma mansoni topbp1 0.0033 0.0106 0.0273
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0035 0.0099
Leishmania major beta tubulin 0.0022 0.0067 0.086
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0053 0.0186 0.0477
Onchocerca volvulus Matrilysin homolog 0.0715 0.2736 0.4488
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0176 0.0452
Loa Loa (eye worm) histone methyltransferase 0.0008 0.001 0.0015
Brugia malayi Matrixin family protein 0.0715 0.2736 0.4118
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0054 0.0188 0.0188
Schistosoma mansoni neuropeptide receptor 0.002 0.0057 0.0146
Entamoeba histolytica hypothetical protein 0.0035 0.0116 0.0721
Brugia malayi Hemopexin family protein 0.1014 0.3888 0.5852
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0057 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.002 0.0056 0.0162
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0057 0.0057
Schistosoma mansoni polycystin 1-related 0.0017 0.0047 0.012
Echinococcus multilocularis beta tubulin 0.0022 0.0067 0.0067
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Schistosoma mansoni tubulin subunit beta 0.0022 0.0067 0.0171
Echinococcus multilocularis beta tubulin 0.0022 0.0067 0.0067
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0871 0.3337 0.5022
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.001 0.0016
Onchocerca volvulus 0.002 0.0057 0.0089
Leishmania major beta tubulin 0.0022 0.0067 0.086
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0085
Brugia malayi Dopamine receptor protein 1 0.002 0.0057 0.0085
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0413 0.1574 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0057 0.0085
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0074 0.0265 0.0399
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Entamoeba histolytica acyl-coA synthetase, putative 0.002 0.0056 0.0343
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0052 0.06
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0057 0.0057
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0074 0.0265 0.3531
Trichomonas vaginalis tubulin gamma chain, putative 0.0022 0.0067 0.0866
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.001 0.001
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0074 0.0265 0.0399
Onchocerca volvulus Protein ultraspiracle homolog 0.0008 0.001 0.0013
Schistosoma mansoni chromosome transmission fidelity factor 0.0033 0.0106 0.0273
Leishmania major beta tubulin 0.0022 0.0067 0.086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0057 0.0146
Loa Loa (eye worm) patched family protein 0.0025 0.0077 0.0115
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0004
Schistosoma mansoni opsin-like receptor 0.002 0.0057 0.0146
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.001 0.0027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0038 0.0127 0.0192
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0059 0.0764
Brugia malayi hypothetical protein 0.0033 0.0106 0.016
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0056 0.0724
Leishmania major beta tubulin 0.0022 0.0067 0.086
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.001 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0265 0.3206
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0016
Brugia malayi Cytochrome P450 family protein 0.0014 0.0035 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0038 0.0127 0.0127
Brugia malayi Matrixin family protein 0.0715 0.2736 0.4118
Brugia malayi protein C24B5.3 0.0025 0.0077 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0057 0.0057
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0052 0.06
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0035 0.0099
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.001 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.001 0.0016
Onchocerca volvulus 0.1014 0.3888 0.638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0127 0.0328
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0074 0.0265 0.3527
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.001 0.0016
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0057 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.001 0.0016
Trichomonas vaginalis replication factor C large subunit, putative 0.0033 0.0106 0.1398
Echinococcus granulosus cpg binding protein 0.0027 0.0082 0.0082
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Leishmania major beta tubulin 0.0022 0.0067 0.086
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0177 0.0664 0.1
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0056
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.0067 0.0067
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0074 0.0265 0.1672
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0019 0.0052 0.0078
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0033 0.0106 0.1398
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0199 0.0747 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.0035 0.0094
Brugia malayi CXXC zinc finger family protein 0.0025 0.0077 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus multilocularis sterol regulatory element binding protein 0.0177 0.0664 0.0664
Plasmodium falciparum tubulin beta chain 0.0022 0.0067 0.086
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0057 0.0146
Loa Loa (eye worm) patched family protein 0.0025 0.0077 0.0115
Trypanosoma brucei lanosterol synthase 0.0218 0.0822 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0263 0.3505
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.001 0.001
Schistosoma mansoni tubulin subunit beta 0.0022 0.0067 0.0171
Onchocerca volvulus 0.0025 0.0077 0.0122
Leishmania major beta tubulin 0.0022 0.0067 0.086
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0033 0.0106 0.5
Trypanosoma cruzi beta tubulin, putative 0.0022 0.0067 0.0782
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0019 0.0052 0.066
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0199 0.0747 1
Schistosoma mansoni topbp1 0.0033 0.0106 0.0273
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0019 0.0052 0.034
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0057 0.0057
Plasmodium vivax transporter, putative 0.0382 0.1451 1
Schistosoma mansoni biogenic amine receptor 0.002 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.0067 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.0076 0.0273 0.0411
Mycobacterium tuberculosis Possible exported protein 0.0917 0.3514 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.009
Onchocerca volvulus 0.002 0.0057 0.0089
Schistosoma mansoni hypothetical protein 0.0122 0.045 0.1158
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0057 0.0146
Onchocerca volvulus 0.0074 0.0265 0.0431
Echinococcus granulosus tubulin beta 4A class IVa 0.0022 0.0067 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0057 0.0146
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0044 0.0148 0.0223
Schistosoma mansoni neuropeptide receptor 0.002 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0057 0.0057
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0006 0.0002 0.0004
Schistosoma mansoni growth factor receptor-bound protein 0.0038 0.0128 0.0329
Leishmania major beta tubulin 0.0022 0.0067 0.086
Echinococcus multilocularis tubulin beta 1 chain 0.0022 0.0067 0.0067
Echinococcus granulosus fmrfamide receptor 0.002 0.0057 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0265 0.3206
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Brugia malayi Pax transcription activation domain interacting protein 0.0033 0.0106 0.016
Giardia lamblia Prenyltransferase 0.0199 0.0747 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0035 0.0099
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0016
Echinococcus granulosus growth factor receptor bound protein 2 0.0038 0.0128 0.0128
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0199 0.0747 1
Schistosoma mansoni kinase 0.0037 0.0124 0.0319
Plasmodium falciparum lipid/sterol:H+ symporter 0.0025 0.0077 0.0997
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0057 0.0146
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0056 0.0162
Brugia malayi AMP-binding enzyme family protein 0.002 0.0056 0.0085
Brugia malayi AMP-binding enzyme family protein 0.002 0.0056 0.0085
Schistosoma mansoni amine GPCR 0.002 0.0057 0.0146
Brugia malayi Cytochrome P450 family protein 0.0014 0.0035 0.0053
Brugia malayi Patched family protein 0.0025 0.0077 0.0115
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0057 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0057 0.0057
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0033 0.0106 0.0311
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0263 0.3505
Loa Loa (eye worm) hypothetical protein 0.003 0.0095 0.0143
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0054 0.0188 0.0484
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0035 0.0053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.001 0.0027
Onchocerca volvulus 0.002 0.0057 0.0089
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Echinococcus multilocularis growth factor receptor bound protein 2 0.0038 0.0128 0.0128
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0074 0.0265 0.3531
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0077 0.0914
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0057 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.0035 0.0094
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Echinococcus granulosus g-protein coupled receptor 0.002 0.0057 0.0057
Echinococcus multilocularis nibrin 0.0033 0.0106 0.0106
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.0035 0.0094
Brugia malayi beta-tubulin, identical 0.0022 0.0067 0.01
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0057 0.0057
Loa Loa (eye worm) tubulin beta-2A chain 0.0022 0.0067 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0106 0.1398
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0115
Brugia malayi Sex muscle abnormal protein 5 0.0038 0.0128 0.0192
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0057 0.0057
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0057 0.0057
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0057 0.0057
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0033 0.0033
Entamoeba histolytica hypothetical protein 0.0035 0.0116 0.0721
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0188 0.2267
Leishmania major beta tubulin 0.0022 0.0067 0.086
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0074 0.0265 0.3527
Echinococcus multilocularis neuropeptide receptor 0.002 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.002 0.0057 0.0146
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0057 0.0146
Onchocerca volvulus Protein patched homolog 0.0025 0.0077 0.0122
Leishmania major beta tubulin 0.0022 0.0067 0.086
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0054 0.0188 0.1282

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 33 % In vitro antagonist activity at GNRHR in CD rat anterior pituitary gland assessed as inhibition of LH-RH-stimulated LH release at compound to LH-RH molar ratio of 4000 after 4 hrs by radioimmunoassay ChEMBL. 385877

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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