Detailed information for compound 200365

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.432 | Formula: C21H25F3N2
  • H donors: 0 H acceptors: 0 LogP: 5.41 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1cccc(c1)N1CCN(CC1)CCCCc1ccccc1)(F)F
  • InChi: 1S/C21H25F3N2/c22-21(23,24)19-10-6-11-20(17-19)26-15-13-25(14-16-26)12-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-11,17H,4-5,9,12-16H2
  • InChiKey: DCDOFEWPXKNFQY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sigma non-opioid intracellular receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0024 0.0197 0.0324
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0221 0.0393
Loa Loa (eye worm) hypothetical protein 0.0071 0.0796 0.1413
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0102 0.0084
Toxoplasma gondii exonuclease III APE 0.0018 0.0117 0.0222
Brugia malayi intermediate filament protein 0.0026 0.0221 0.0393
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0117 0.0182
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.1831 0.3255
Schistosoma mansoni microtubule-associated protein tau 0.0718 0.9161 1
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0045 0.0457 0.0788
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0359 0.0613
Echinococcus granulosus phd:f box containing protein 0.0017 0.0099 0.0107
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0123 0.0216
Schistosoma mansoni lamin 0.0026 0.0221 0.0226
Mycobacterium ulcerans beta-lactamase 0.0071 0.0796 0.1704
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0099 0.0151
Schistosoma mansoni intermediate filament proteins 0.0026 0.0221 0.0226
Loa Loa (eye worm) acetyltransferase 0.0151 0.1831 0.3253
Toxoplasma gondii type I fatty acid synthase 0.0016 0.0091 0.0167
Echinococcus granulosus single minded 2 0.0039 0.0381 0.0415
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0197 0.1394
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0719 0.0784
Schistosoma mansoni ap endonuclease 0.0018 0.0117 0.0111
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0381 0.0799
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0045 0.0457 0.0788
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0123 0.0235
Brugia malayi Cytochrome P450 family protein 0.001 0.0015 0.0026
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0044
Loa Loa (eye worm) carboxylesterase 0.0011 0.0025 0.0042
Echinococcus granulosus acetylcholinesterase 0.0065 0.0728 0.0793
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0057 0.0076
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0068
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0796 0.1369
Schistosoma mansoni DNA polymerase eta 0.0019 0.0123 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0174
Trypanosoma cruzi quinone oxidoreductase, putative 0.0016 0.0091 0.0136
Trypanosoma brucei unspecified product 0.0013 0.0048 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0068
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0045 0.0457 0.0965
Echinococcus granulosus carboxylesterase 5A 0.0065 0.0728 0.0793
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0099 0.0098
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0025 0.0026
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0102 0.0181
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0102 0.019
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.1969 0.3499
Mycobacterium ulcerans oxidoreductase 0.0016 0.0091 0.0167
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0365 0.46 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0123 0.1269
Leishmania major protein kinase, putative 0.0014 0.0064 0.0087
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0796 0.1392
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0123 0.0118
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0407 0.8536
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0796 0.1369
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0042
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0025 0.0011
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0015 0.0015
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0588 0.1022
Echinococcus granulosus acetylcholinesterase 0.0065 0.0728 0.0793
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0042
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0045 0.0457 0.0965
Loa Loa (eye worm) acetylcholinesterase 1 0.0065 0.0728 0.1292
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0697 0.0696
Loa Loa (eye worm) hypothetical protein 0.0024 0.0197 0.0347
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0045 0.0457 0.0775
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0045 0.0457 0.0788
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0117 0.0115
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0381 0.038
Schistosoma mansoni alcohol dehydrogenase 0.0365 0.46 0.5013
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0359 0.039
Leishmania major hypothetical protein, conserved 0.0016 0.0091 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Trypanosoma brucei Trans-2-enoyl-ACP reductase 1, putative 0.0016 0.0091 0.0136
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0719 0.077
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0359 0.0613
Schistosoma mansoni quinone oxidoreductase 0.0016 0.0091 0.0084
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0117 0.0178
Loa Loa (eye worm) hypothetical protein 0.0445 0.5625 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0102 0.0155
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0796 0.1704
Echinococcus granulosus microtubule associated protein 2 0.0718 0.9161 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0796 0.1369
Brugia malayi hypothetical protein 0.0016 0.0085 0.0151
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0045 0.0457 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0042
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0045 0.0457 0.0965
Mycobacterium tuberculosis Conserved protein 0.0071 0.0796 0.1369
Loa Loa (eye worm) hypothetical protein 0.0026 0.0215 0.038
Loa Loa (eye worm) acyl carrier protein 0.0028 0.0248 0.0438
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0197 0.0324
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0025 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0117 0.0182
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0025 0.0011
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0099 0.0098
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0045 0.0457 0.0775
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0123 0.0218
Mycobacterium leprae Probable lipase LipE 0.0071 0.0796 0.1704
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0064 0.0087
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.0728 0.078
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0588 0.1022
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0588 0.1044
Loa Loa (eye worm) hypothetical protein 0.0065 0.0728 0.1292
Mycobacterium ulcerans lipase LipD 0.0071 0.0796 0.1704
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0028 0.0248 0.0508
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0365 0.46 1
Schistosoma mansoni acetylcholinesterase 0.0011 0.0025 0.0011
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0057 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0123 0.0216
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0045 0.0457 0.0775
Loa Loa (eye worm) hypothetical protein 0.0026 0.0221 0.0391
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0099 0.0093
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0045 0.0457 0.0813
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0796 0.1704
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0025 0.0023
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0796 0.1415
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0588 0.1022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0701 0.075
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0365 0.46 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0123 0.013
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0455 0.096
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0359 0.0613
Schistosoma mansoni cpg binding protein 0.0032 0.029 0.0301
Brugia malayi Carboxylesterase family protein 0.0065 0.0728 0.1294
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0123 0.0218
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0045 0.0457 0.5606
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0365 0.46 0.8035
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0025 0.0026
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0099 0.0174
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0045 0.0457 0.0775
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0796 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0057 0.042
Mycobacterium ulcerans short-chain dehydrogenase 0.0045 0.0457 0.0965
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0268 0.0474
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0455 0.096
Mycobacterium tuberculosis Conserved protein 0.0071 0.0796 0.1369
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0796 0.1704
Trypanosoma brucei oxidoreductase, putative 0.0045 0.0457 0.0788
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0023 0.0024
Schistosoma mansoni cpg binding protein 0.0032 0.029 0.0301
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0796 0.1369
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0588 0.1251
Mycobacterium ulcerans quinone oxidoreductase 0.0045 0.0457 0.0965
Echinococcus granulosus synaptic vesicle membrane protein VAT 1 0.0016 0.0091 0.0098
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0044
Loa Loa (eye worm) inositol-1 0.0037 0.0359 0.0635
Mycobacterium tuberculosis Carboxylesterase LipT 0.0011 0.0025 0.0018
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0025 0.0023
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0045 0.0457 0.0775
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0359 0.075
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0099 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0048 0.0059
Mycobacterium tuberculosis Possible dehydrogenase 0.0045 0.0457 0.0775
Brugia malayi Cytochrome P450 family protein 0.001 0.0015 0.0026
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0697 0.0746
Brugia malayi Alcohol dehydrogenase class III 0.0365 0.46 0.8177
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0796 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0046 0.0044
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0556 0.0592
Leishmania major hypothetical protein, conserved 0.0017 0.0099 0.0151
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0099 0.0093
Brugia malayi jmjC domain containing protein 0.0017 0.0099 0.0177
Trypanosoma cruzi oxidoreductase, putative 0.0016 0.0091 0.0136
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0123 0.0132
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0045 0.0457 0.0788
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0588 0.7308
Mycobacterium ulcerans polyketide synthase 0.0045 0.0457 0.0965
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0455 0.5579
Brugia malayi Inositol-1 0.0037 0.0359 0.0638
Loa Loa (eye worm) beta-lactamase 0.0071 0.0796 0.1413
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0025 0.0026
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0197 0.0324
Mycobacterium ulcerans oxidoreductase 0.0045 0.0457 0.0965
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Toxoplasma gondii ABC1 family protein 0.0071 0.0796 0.1704
Brugia malayi jmjC domain containing protein 0.0017 0.0099 0.0177
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0102 0.0155
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0045 0.0457 0.5606
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0064 0.0113
Schistosoma mansoni gliotactin 0.0011 0.0025 0.0011
Loa Loa (eye worm) hypothetical protein 0.0045 0.0457 0.081
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0057 0.042
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0045 0.0457 0.0775
Echinococcus multilocularis carboxylesterase 5A 0.0065 0.0728 0.0726
Brugia malayi jmjC domain containing protein 0.0065 0.0719 0.1279
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0365 0.46 0.8177
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.5625 1
Brugia malayi Cytochrome P450 family protein 0.0066 0.0731 0.13
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0359 0.0357
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0102 0.0101
Toxoplasma gondii type I fatty acid synthase, putative 0.0045 0.0457 0.0965
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0045 0.0457 0.0775
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0102 0.0179
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0025 0.0011
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0359 0.075
Onchocerca volvulus Fatty acid synthase homolog 0.0028 0.0248 0.0487
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0045 0.0457 0.0965
Leishmania major DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0221 0.0391
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0661 0.141
Onchocerca volvulus 0.0028 0.0248 0.0487
Brugia malayi Carboxylesterase family protein 0.0065 0.0728 0.1294
Echinococcus multilocularis 0.001 0.0015 0.0013
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0023 0.0022
Echinococcus multilocularis geminin 0.0346 0.4346 0.4345
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0588 0.1022
Leishmania major zinc-binding dehydrogenase-like protein 0.0028 0.0248 0.0415
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0102 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0796 0.1392
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0102 0.0155
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0455 0.0495
Brugia malayi beta-lactamase family protein 0.0071 0.0796 0.1415
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0099 0.0185
Schistosoma mansoni zinc binding dehydrogenase 0.0045 0.0457 0.0484
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0407 1
Echinococcus multilocularis microtubule associated protein 2 0.0718 0.9161 0.916
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0796 0.0795
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0042
Mycobacterium ulcerans oxidoreductase FadB5 0.0045 0.0457 0.0965
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0045 0.0457 0.0788
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0102 0.0155
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0588 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0588 0.1022
Leishmania major hypothetical protein, conserved 0.0016 0.0091 0.0136
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0123 0.0192
Loa Loa (eye worm) hypothetical protein 0.0227 0.2817 0.5007
Schistosoma mansoni single-minded 0.0052 0.0556 0.0592
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0123 0.0192
Loa Loa (eye worm) CYP4Cod1 0.001 0.0015 0.0024
Echinococcus multilocularis neuroligin 0.0011 0.0025 0.0023
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.5625 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0796 0.1413
Onchocerca volvulus 0.0039 0.0381 0.0779
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0117 0.0205
Loa Loa (eye worm) cytochrome P450 family protein 0.0066 0.0731 0.1297
Echinococcus multilocularis musashi 0.0026 0.0221 0.022
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0057 0.042
Echinococcus granulosus lamin dm0 0.0026 0.0221 0.024
Onchocerca volvulus 0.0026 0.0221 0.0429
Mycobacterium ulcerans quinone oxidoreductase 0.0045 0.0457 0.0965
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0359 0.433
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0123 0.0235
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.0009
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0045 0.0457 0.0965
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0197 0.0324
Brugia malayi jmjC domain containing protein 0.0063 0.0697 0.124
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0057 0.042
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0588 0.1022
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0015 0.0024
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0117 0.0126
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0025 0.0011
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0407 0.6162
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0045 0.0457 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0365 0.46 1
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0015 0.0024
Echinococcus granulosus dna polymerase kappa 0.0019 0.0123 0.0132
Trypanosoma cruzi quinone oxidoreductase, putative 0.0016 0.0091 0.0136
Leishmania major d-xylulose reductase, putative 0.0045 0.0457 0.0788
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0309 0.0515
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0042
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0045 0.0457 0.0965
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0796 0.0854
Echinococcus granulosus dna polymerase eta 0.0019 0.0123 0.0132
Mycobacterium leprae Possible regulatory protein 0.0014 0.0057 0.0093
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.5625 1
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0028 0.0248 0.0415
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0099 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0588 0.7308
Schistosoma mansoni lamin 0.0026 0.0221 0.0226
Loa Loa (eye worm) hypothetical protein 0.0045 0.0457 0.081
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0117 0.0222
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0099 0.0151
Brugia malayi hypoxia-induced factor 1 0.0162 0.1969 0.3501
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0091 0.0136
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0057 0.0061
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0025 0.0018
Brugia malayi jmjC domain containing protein 0.0017 0.0099 0.0177
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0359 0.433
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0045 0.0457 0.0775
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0045 0.0457 0.0775
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0099 0.0151
Leishmania major oxidoreductase, putative 0.0045 0.0457 0.0788
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0197 0.3153
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0057 0.042
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0045 0.0457 0.0775
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0045 0.0457 0.0775
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0099 0.0098
Brugia malayi hypothetical protein 0.0175 0.2145 0.3813
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0016 0.0091 0.0134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Loa Loa (eye worm) carboxylesterase 0.0065 0.0728 0.1292
Leishmania major zinc binding dehydrogenase-like protein 0.0045 0.0457 0.0788
Trypanosoma brucei protein kinase, putative 0.0055 0.0588 0.1022
Mycobacterium ulcerans alcohol dehydrogenase AdhA 0.0016 0.0091 0.0167
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0122 0.0131
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0045 0.0457 0.0775
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0057 0.0056
Onchocerca volvulus 0.0045 0.0457 0.0945
Brugia malayi beta-lactamase family protein 0.0071 0.0796 0.1415
Leishmania major quinone oxidoreductase-like protein,alcohol dehydrogenase, zinc-containing-like protein 0.0016 0.0091 0.0136
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0796 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0719 0.1277
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0102 0.0101
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0057 0.042
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0045 0.0457 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0123 0.0192
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0099 0.0174
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0099 0.0107
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0174
Echinococcus granulosus cpg binding protein 0.0032 0.029 0.0315
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0045 0.0457 0.0498
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0796 1
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0057 0.042
Mycobacterium tuberculosis Possible dehydrogenase 0.0045 0.0457 0.0775
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0588 0.7308
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0046 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Mycobacterium ulcerans oxidoreductase 0.0028 0.0248 0.0508
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0123 0.0189
Loa Loa (eye worm) hypothetical protein 0.0071 0.0796 0.1413
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0588 0.0627
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0102 0.0095
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0045 0.0457 0.0965
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0102 0.019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0174
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0122 0.012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0042
Onchocerca volvulus 0.0071 0.0796 0.1685
Trypanosoma brucei unspecified product 0.0019 0.0123 0.0192
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0796 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0796 0.1413
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0359 0.0613
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0796 0.0867
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0588 0.1022
Schistosoma mansoni hypothetical protein 0.0346 0.4346 0.4735
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.1776 0.1938
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0728 0.0726
Mycobacterium tuberculosis Conserved protein 0.0071 0.0796 0.1369
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0123 0.0189
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0588 0.0641
Schistosoma mansoni inositol monophosphatase 0.0037 0.0359 0.0376
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0117 0.0559
Leishmania major hypothetical protein, conserved 0.0071 0.0796 0.1392
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0796 0.1369
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0042
Onchocerca volvulus 0.0026 0.0221 0.0429
Mycobacterium ulcerans hypothetical protein 0.0071 0.0796 0.1704
Onchocerca volvulus Putative alcohol dehydrogenase 0.0365 0.46 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0117 0.5
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.1831 0.183
Brugia malayi isocitrate dehydrogenase 0.0017 0.0102 0.0181
Brugia malayi MAP kinase sur-1 0.0055 0.0588 0.1046
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0221 0.0391
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0719 0.077
Trypanosoma cruzi oxidoreductase, putative 0.0028 0.0248 0.0415
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0123 0.0192
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0045 0.0457 0.0775
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0309 0.0641
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0057 0.0061
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0045 0.0457 0.0965
Mycobacterium ulcerans dehydrogenase 0.0045 0.0457 0.0965
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0048 0.0059
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0117 0.119
Onchocerca volvulus 0.003 0.0268 0.0532
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0057 0.042
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0045 0.0457 0.0775
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0796 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0057 0.0056
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0102 0.0153
Echinococcus granulosus neuroligin 0.0011 0.0025 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0588 0.7308
Leishmania major nuclear receptor binding factor-like protein 0.0028 0.0248 0.0415
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0588 0.0587
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0123 0.0121
Echinococcus multilocularis synaptic vesicle membrane protein VAT 1 0.0016 0.0091 0.009
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0359 0.7109
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0102 0.0155
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0359 0.433
Echinococcus multilocularis dna polymerase eta 0.0019 0.0123 0.0121
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0045 0.0457 0.0813
Loa Loa (eye worm) cytochrome P450 0.001 0.0015 0.0024
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0045 0.0457 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0045 0.0457 0.0788
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0057 0.042
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0796 0.1369
Mycobacterium leprae Probable oxidireductase 0.0045 0.0457 0.0965
Leishmania major quinone oxidoreductase, putative 0.0045 0.0457 0.0788
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0099
Brugia malayi jmjC domain containing protein 0.0017 0.0099 0.0177
Brugia malayi cytochrome P450 0.001 0.0015 0.0026
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0796 0.0854
Echinococcus multilocularis lamin dm0 0.0026 0.0221 0.022
Echinococcus multilocularis cpg binding protein 0.0032 0.029 0.0289
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 0.0321 0.4025 0.7027
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0321 0.4025 0.7027
Brugia malayi hypothetical protein 0.0024 0.0197 0.0349
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0197 0.0396
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0044
Schistosoma mansoni cpg binding protein 0.003 0.0268 0.0277
Trypanosoma cruzi oxidoreductase, putative 0.0045 0.0457 0.0788
Trypanosoma brucei oxidoreductase, putative 0.0045 0.0457 0.0788
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0365 0.46 1
Brugia malayi Carboxylesterase family protein 0.0011 0.0025 0.0044
Onchocerca volvulus 0.0071 0.0796 0.1685
Loa Loa (eye worm) hypothetical protein 0.0045 0.0457 0.081
Trypanosoma brucei unspecified product 0.0013 0.0048 0.0059
Loa Loa (eye worm) oxidoreductase 0.0016 0.0091 0.016
Loa Loa (eye worm) hypothetical protein 0.0065 0.0728 0.1292
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0455 0.5579
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0102 0.0101
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0045 0.0457 0.0775
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0057 0.5
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0455 0.5106
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0025 0.0022
Mycobacterium ulcerans quinone reductase Qor 0.0045 0.0457 0.0965
Onchocerca volvulus 0.0071 0.0796 0.1685
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0123 0.0118
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0099 0.0093
Echinococcus granulosus intermediate filament protein 0.0026 0.0221 0.024
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0028 0.0248 0.0441
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0045 0.0457 0.0965
Schistosoma mansoni inositol monophosphatase 0.0037 0.0359 0.0376
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0079
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0102 0.0037
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0025 0.0018
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0064 0.0087
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0064 0.0087
Trichomonas vaginalis esterase, putative 0.0071 0.0796 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0028 0.0248 0.0441
Leishmania major DNA polymerase eta, putative 0.0019 0.0123 0.0192
Loa Loa (eye worm) hypothetical protein 0.0175 0.2145 0.3811
Mycobacterium tuberculosis Probable oxidoreductase 0.0045 0.0457 0.0775
Echinococcus multilocularis lamin 0.0026 0.0221 0.022
Mycobacterium leprae Probable polyketide synthase Pks1 0.0045 0.0457 0.0965
Brugia malayi beta-lactamase 0.0071 0.0796 0.1415
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0099 0.0093
Loa Loa (eye worm) hypothetical protein 0.0071 0.0796 0.1413
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0057 0.042
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0796 0.1392
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0588 0.0641
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0123 0.018
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0102 0.011
Echinococcus granulosus lamin 0.0026 0.0221 0.024
Leishmania major oxidoreductase-like protein 0.0045 0.0457 0.0788
Onchocerca volvulus 0.0014 0.0057 0.0071
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0064 0.0087
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.1831 0.1986
Brugia malayi hypothetical protein 0.0011 0.0025 0.0044
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0016 0.0091 0.0162
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.5625 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0359 0.7109
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0099 0.0174
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0117 0.0182
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0123 0.0192
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.5721 1
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0381 0.0678
Leishmania major protein kinase, putative 0.0014 0.0064 0.0087
Brugia malayi Cytochrome P450 family protein 0.001 0.0015 0.0026
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0057 0.0076
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0025 0.0023
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0102 0.0101
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0057 0.0099
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0588 0.0587
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0365 0.46 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0117 0.119
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0123 0.1269
Brugia malayi PAS domain containing protein 0.0052 0.0556 0.0989
Loa Loa (eye worm) hypothetical protein 0.0071 0.0796 0.1413
Schistosoma mansoni ap endonuclease 0.0018 0.0117 0.0111
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0064 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0123 0.0192
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0045 0.0457 0.5606
Trypanosoma cruzi oxidoreductase, putative 0.0045 0.0457 0.0788
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0117 0.0182
Loa Loa (eye worm) hypothetical protein 0.0028 0.0248 0.0438
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0117 0.0247
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0117 0.0207
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0123 0.0121
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0099 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0057 0.042
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0796 0.1369
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0697 0.076
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0697 0.0696
Schistosoma mansoni hypothetical protein 0.0346 0.4346 0.4735
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0197 0.3153
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0045 0.0457 0.0788
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0048 0.0059
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0045 0.0457 0.0965
Toxoplasma gondii quinone oxidoreductase, putative 0.0045 0.0457 0.0965
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0045 0.0457 1
Echinococcus granulosus geminin 0.0346 0.4346 0.4743
Brugia malayi CXXC zinc finger family protein 0.003 0.0268 0.0477
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0099 0.0185
Loa Loa (eye worm) hypothetical protein 0.0071 0.0796 0.1413
Loa Loa (eye worm) carboxylesterase 0.0011 0.0025 0.0042
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0099 0.0098
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0728 0.0726
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0123 0.0192
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0365 0.46 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.4 nM Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand ChEMBL. 1662725
Ki (binding) = 5.4 nM Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand ChEMBL. 1662725

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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