Detailed information for compound 227421

Basic information

Technical information
  • TDR Targets ID: 227421
  • Name: N-ethyl-3,5-dimethyladamantan-1-amine
  • MW: 207.355 | Formula: C14H25N
  • H donors: 1 H acceptors: 0 LogP: 3.63 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC12CC3CC(C2)(CC(C1)(C3)C)C
  • InChi: 1S/C14H25N/c1-4-15-14-7-11-5-12(2,9-14)8-13(3,6-11)10-14/h11,15H,4-10H2,1-3H3
  • InChiKey: FTXVGNKOUJOOHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-ethyl-3,5-dimethyl-adamantan-1-amine
  • N-ethyl-3,5-dimethyl-1-adamantanamine
  • (3,5-dimethyl-1-adamantyl)-ethyl-amine
  • AIDS-231691
  • AIDS231691
  • Tricyclo[3.3.1.1~3,7~]decan-1-amine, N-ethyl-3,5-dimethyl-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, ionotropic, N-methyl-D-aspartate 3A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0145 0.0253 0.0292
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.036 0.0416
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0009 0.0001
Onchocerca volvulus AMP deaminase 2 homolog 0.2505 0.4811 0.5559
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0008 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0056 0.0064
Schistosoma mansoni hypothetical protein 0.0364 0.0676 0.0781
Entamoeba histolytica hypothetical protein 0.0036 0.0043 0.005
Schistosoma mansoni dep domain containing protein 0.002 0.0011 0.0013
Echinococcus multilocularis transient receptor potential ion channel A 0.0111 0.0187 0.0187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0246 0.0284
Echinococcus granulosus Smad4 0.0033 0.0038 0.0044
Onchocerca volvulus 0.0284 0.0522 0.0603
Toxoplasma gondii hypothetical protein 0.002 0.0011 0.0003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0056 0.0064
Loa Loa (eye worm) hypothetical protein 0.0177 0.0314 0.0363
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0142 0.0165
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0056 0.0064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0104 0.0104
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0003 0.0004
Schistosoma mansoni Smad4 0.0033 0.0038 0.0044
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0016 0.0018
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0002 0.0002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.004 0.0051 0.0051
Leishmania major AMP deaminase, putative 0.2505 0.4811 0.5558
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0362 0.0672 0.0777
Entamoeba histolytica AMP deaminase, putative 0.2505 0.4811 0.5559
Onchocerca volvulus 0.0032 0.0036 0.0041
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0305 0.0563 0.0651
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.4495 0.8655 1
Trichomonas vaginalis ran, putative 0.0025 0.0022 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0024 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0246 0.0284
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0002 0.0002
Brugia malayi RNA, U transporter 1 0.0097 0.016 0.0185
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0142 0.0165
Mycobacterium ulcerans adenosine deaminase 0.4495 0.8655 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0004 0.0004
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0051 0.0059
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.0206 0.0228
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.01 0.01
Brugia malayi Importin beta-1 subunit 0.0034 0.0039 0.0045
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0002 0.0002
Plasmodium falciparum sentrin-specific protease 1 0.0046 0.0062 0.0062
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0004 0.0004
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0075 0.0087
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0042 0.0039
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0002 0.0002
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0024 0.0018
Schistosoma mansoni Smad4 0.0015 0.0002 0.0002
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0039 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0056 0.0116
Brugia malayi MH1 domain containing protein 0.0033 0.0038 0.0044
Schistosoma mansoni glutamate receptor kainate 0.004 0.0051 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0009 0.0001
Schistosoma mansoni dishevelled 0.002 0.0011 0.0013
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0022 0.0015
Schistosoma mansoni glutamate receptor NMDA 0.004 0.0051 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0022 0.0045
Plasmodium falciparum importin beta, putative 0.0034 0.0039 0.0035
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0011 0.0003
Echinococcus multilocularis tumor protein p63 0.0342 0.0633 0.0633
Brugia malayi MH2 domain containing protein 0.0033 0.0038 0.0044
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0015 0.0002 0.0002
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.0056 0.0064
Entamoeba histolytica AMP deaminase, putative 0.2505 0.4811 0.5559
Brugia malayi Transient-receptor-potential like protein 0.0043 0.0056 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.005 0.007 0.0081
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0011 0.0013
Trichomonas vaginalis set domain proteins, putative 0.0284 0.0522 0.0603
Echinococcus granulosus nmda type glutamate receptor 0.0015 0.0002 0.0002
Schistosoma mansoni transient receptor potential channel 0.0076 0.012 0.0138
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0024 0.0018
Loa Loa (eye worm) Smad1 0.0033 0.0038 0.0044
Brugia malayi DIX domain containing protein 0.002 0.0011 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0074 0.0086
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0046 0.0062 0.0071
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.004 0.0051 0.0059
Echinococcus multilocularis sentrin specific protease 1 0.0046 0.0062 0.0062
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0008 0.0018
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0008 0.0007
Trypanosoma cruzi AMP deaminase, putative 0.2505 0.4811 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0022 0.0025
Plasmodium vivax SET domain protein, putative 0.0036 0.0042 0.0039
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0022 0.0025
Onchocerca volvulus Huntingtin homolog 0.0145 0.0253 0.0292
Schistosoma mansoni smad 0.0015 0.0002 0.0002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0041 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0004 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0024 0.0028
Plasmodium vivax importin-beta 2, putative 0.0034 0.0039 0.0035
Echinococcus granulosus importin subunit beta 1 0.0034 0.0039 0.0045
Loa Loa (eye worm) hypothetical protein 0.0038 0.0046 0.0053
Loa Loa (eye worm) hypothetical protein 0.2748 0.5281 0.6101
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0068 0.0104 0.012
Loa Loa (eye worm) glutathione reductase 0.0053 0.0075 0.0087
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0056 0.0064
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0193 0.0345 0.0399
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0022 0.1134
Schistosoma mansoni hypothetical protein 0.039 0.0727 0.084
Trichomonas vaginalis adenosine deaminase, putative 0.4495 0.8655 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0282 0.0518 0.0598
Schistosoma mansoni zinc finger protein 0.0015 0.0002 0.0002
Trypanosoma brucei AMP deaminase, putative 0.2505 0.4811 1
Brugia malayi hypothetical protein 0.0036 0.0043 0.005
Brugia malayi Smad1 0.0033 0.0038 0.0044
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0028
Schistosoma mansoni smad 0.0033 0.0038 0.0044
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0004 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0584 0.11 0.1271
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0002
Schistosoma mansoni intermediate filament proteins 0.0032 0.0036 0.0041
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0003 0.0003
Schistosoma mansoni lamin 0.0032 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.0181 0.0322 0.0372
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0005 0.0006
Echinococcus granulosus transient receptor potential gamma protein 0.0115 0.0195 0.0225
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.002 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0028
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0038 0.0038
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0142 0.0165
Loa Loa (eye worm) hypothetical protein 0.0046 0.0062 0.0071
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0022 0.0015
Schistosoma mansoni glutamate receptor kainate 0.004 0.0051 0.0059
Schistosoma mansoni alpha-glucosidase 0.0166 0.0293 0.0339
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.0206 0.0228
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0004 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0246 0.0246
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0181 0.0322 0.0372
Echinococcus multilocularis GPCR, family 2 0.0181 0.0322 0.0322
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0068 0.0104 0.011
Brugia malayi hypothetical protein 0.002 0.0011 0.0013
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0011 0.0011
Echinococcus granulosus segment polarity protein dishevelled 0.002 0.0011 0.0013
Schistosoma mansoni glutamate receptor NMDA 0.004 0.0051 0.0059
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0002
Echinococcus multilocularis muscleblind protein 1 0.0177 0.0314 0.0314
Schistosoma mansoni adenosine deaminase 0.4495 0.8655 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0193 0.0345 0.0399
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0008 0.0007
Plasmodium falciparum AMP deaminase, putative 0.2505 0.4811 0.5554
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0068 0.0104 0.011
Echinococcus granulosus adenosine deaminase 0.4495 0.8655 1
Brugia malayi Isocitrate dehydrogenase 0.0068 0.0104 0.012
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.4495 0.8655 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0042 0.0049
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0056 0.0064
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0008 0.0018
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0075 0.0156
Echinococcus granulosus glutamate receptor subunit protein glur 0.0015 0.0002 0.0002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.0206 0.0228
Echinococcus granulosus zinc finger protein 0.0026 0.0024 0.0028
Entamoeba histolytica hypothetical protein 0.0028 0.0027 0.0031
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0011 1
Echinococcus multilocularis muscleblind protein 0.0177 0.0314 0.0314
Plasmodium vivax glutathione reductase, putative 0.0053 0.0075 0.0077
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0043 0.005
Plasmodium vivax sentrin-specific protease 1, putative 0.0046 0.0062 0.0062
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0181 0.0322 0.0322
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0246 0.0246
Echinococcus granulosus snurportin 1 0.0364 0.0676 0.0781
Echinococcus multilocularis isocitrate dehydrogenase 0.0068 0.0104 0.0104
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0068 0.0104 0.0104
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0046 0.0062 0.0062
Schistosoma mansoni Smad4 0.0015 0.0002 0.0002
Echinococcus multilocularis smad 0.0033 0.0038 0.0038
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0046 0.0062 0.0071
Echinococcus multilocularis lysosomal alpha glucosidase 0.0193 0.0345 0.0345
Echinococcus granulosus GPCR family 2 0.0181 0.0322 0.0372
Mycobacterium ulcerans hypothetical protein 0.0026 0.0024 0.0018
Toxoplasma gondii isocitrate dehydrogenase 0.0068 0.0104 0.011
Plasmodium falciparum adenosine deaminase 0.4495 0.8655 1
Plasmodium vivax adenosine/AMP deaminase, putative 0.2505 0.4811 0.5554
Echinococcus multilocularis segment polarity protein dishevelled 0.002 0.0011 0.0011
Leishmania major GTP-binding protein, putative 0.0025 0.0022 0.0023
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0292 0.0538 0.0622
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0008 0.0018
Schistosoma mansoni dishevelled 0.002 0.0011 0.0013
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0015 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.036 0.0416
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0027 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0056 0.0116
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0015 0.0002 0.0002
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0004 0.0008
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0104 0.0118
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0038 0.0044
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.0062 0.0071
Brugia malayi Glutamate receptor 1 precursor 0.004 0.0051 0.0059
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0008 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0584 0.11 0.1271
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0039 0.0077
Trypanosoma cruzi AMP deaminase, putative 0.2505 0.4811 1
Echinococcus granulosus sentrin specific protease 1 0.0046 0.0062 0.0071
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.0177 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0305 0.0563 0.0651
Brugia malayi RNA recognition motif domain containing protein 0.0584 0.11 0.1271
Trypanosoma brucei AMP deaminase, putative 0.2505 0.4811 1
Trichomonas vaginalis glucosylceramidase, putative 0.0305 0.0563 0.0651
Schistosoma mansoni tar DNA-binding protein 0.0584 0.11 0.1271
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0075 0.0077
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0027 0.0031
Schistosoma mansoni lamin 0.0032 0.0036 0.0041
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.002 0.0011 0.0013
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.2505 0.4811 0.5558
Echinococcus multilocularis tar DNA binding protein 0.0584 0.11 0.11
Echinococcus granulosus smad 0.0033 0.0038 0.0044
Loa Loa (eye worm) hypothetical protein 0.0049 0.0067 0.0078
Toxoplasma gondii thioredoxin reductase 0.0053 0.0075 0.0077
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0008 0.0013
Brugia malayi hypothetical protein 0.0517 0.0972 0.1123
Echinococcus granulosus lamin 0.0032 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.0039 0.0048 0.0056
Schistosoma mansoni adenosine deaminase-related 0.4495 0.8655 1
Trypanosoma brucei glucosidase, putative 0.0043 0.0056 0.0112
Schistosoma mansoni smad1 5 8 and 0.0033 0.0038 0.0044
Echinococcus multilocularis NMDA receptor 0.0015 0.0002 0.0002
Schistosoma mansoni zinc finger protein 0.0026 0.0024 0.0028
Brugia malayi hypothetical protein 0.0169 0.0299 0.0346
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.2505 0.4811 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0036 0.0043 0.005
Schistosoma mansoni ran 0.0025 0.0022 0.0025
Schistosoma mansoni hypothetical protein 0.0181 0.0322 0.0372
Leishmania major adenine aminohydrolase 0.4495 0.8655 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0068 0.0104 0.012
Brugia malayi Glutamate receptor 2 precursor 0.004 0.0051 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.036 0.0416
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0043 0.005
Loa Loa (eye worm) hypothetical protein 0.0177 0.0314 0.0363
Loa Loa (eye worm) hypothetical protein 0.0032 0.0036 0.0041
Echinococcus granulosus tar DNA binding protein 0.0584 0.11 0.1271
Plasmodium falciparum thioredoxin reductase 0.0053 0.0075 0.0077
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0045
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.0232 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0042 0.0049
Onchocerca volvulus 0.0106 0.0177 0.0204
Loa Loa (eye worm) hypothetical protein 0.0115 0.0195 0.0225
Brugia malayi isocitrate dehydrogenase 0.0068 0.0104 0.012
Onchocerca volvulus Adenosine deaminase homolog 0.4495 0.8655 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0004 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0024 0.0018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.004 0.0051 0.0059
Entamoeba histolytica hypothetical protein 0.0036 0.0043 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0246 0.0284
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0145 0.0253 0.0292
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0011 0.0003
Brugia malayi Pre-SET motif family protein 0.025 0.0455 0.0526
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0012 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0074 0.0086
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0056 0.0064
Brugia malayi Thioredoxin reductase 0.0053 0.0075 0.0087
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0039 0.0035
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Trypanosoma cruzi AMP deaminase, putative 0.2505 0.4811 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.0056 0.0064
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0008 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0246 0.0284
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.002 0.0011 0.0013
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.0056 0.0064
Loa Loa (eye worm) hypothetical protein 0.2748 0.5281 0.6101
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0047 0.0064 0.0074
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.0206 0.021
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.0056 0.0055
Brugia malayi acetyltransferase, GNAT family protein 0.0292 0.0538 0.0622
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0022 0.0045
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0068 0.0104 0.0216
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.0056 0.0056
Loa Loa (eye worm) nuclear factor I 0.0018 0.0009 0.001
Brugia malayi MH2 domain containing protein 0.0033 0.0038 0.0044
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.0206 0.0228
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0292 0.0538 0.0538
Brugia malayi intermediate filament protein 0.0032 0.0036 0.0041
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0075 0.0075
Brugia malayi latrophilin 2 splice variant baaae 0.039 0.0727 0.084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0008 0.0018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.004 0.0051 0.0059
Loa Loa (eye worm) glutamate receptor 2 0.004 0.0051 0.0059
Onchocerca volvulus 0.0111 0.0188 0.0218
Loa Loa (eye worm) DIX domain-containing protein 0.002 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0752 0.1426 0.1648
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0005 0.0005
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.0232 0.0258
Brugia malayi hypothetical protein 0.0145 0.0253 0.0292
Echinococcus granulosus glutamate receptor 2 0.0025 0.0022 0.0026
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.004 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.002 0.0012 0.0014
Brugia malayi Bromodomain containing protein 0.0045 0.0059 0.0068
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.2505 0.4811 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0397 0.0739 0.0854
Schistosoma mansoni cellular tumor antigen P53 0.005 0.007 0.0081
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0022 0.0025
Echinococcus granulosus short transient receptor potential channel 6 0.0076 0.012 0.0138
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.2748 0.5281 0.6101
Treponema pallidum adenosine deaminase 0.4495 0.8655 1
Toxoplasma gondii isocitrate dehydrogenase 0.0068 0.0104 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.036 0.0416
Echinococcus granulosus transient receptor potential ion channel A 0.0111 0.0187 0.0217
Trichomonas vaginalis glucosylceramidase, putative 0.0211 0.0381 0.044
Trypanosoma cruzi AMP deaminase, putative 0.2505 0.4811 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0064
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0011 0.0003
Schistosoma mansoni ATP-binding cassette transporter 0.004 0.0051 0.0059
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.4495 0.8655 1
Echinococcus multilocularis zinc finger protein 0.0026 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0181 0.0322 0.0372
Onchocerca volvulus 0.005 0.007 0.0081
Brugia malayi MH2 domain containing protein 0.0015 0.0002 0.0002
Plasmodium vivax adenosine deaminase, putative 0.4495 0.8655 1
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0004 0.0002
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.004 0.0051 0.0051
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0008 0.0013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0074 0.0074
Schistosoma mansoni importin beta-1 0.0034 0.0039 0.0045
Echinococcus multilocularis lamin dm0 0.0032 0.0036 0.0036
Schistosoma mansoni regulator of G protein signaling 0.002 0.0011 0.0013
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.002 0.0011 0.0013
Echinococcus multilocularis Smad4 0.0033 0.0038 0.0038
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0142 0.0155
Trypanosoma cruzi AMP deaminase 2, putative 0.1747 0.3348 0.6959
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0068 0.0104 0.0212
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.036 0.0416
Schistosoma mansoni hypothetical protein 0.107 0.204 0.2357
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.004 0.0051 0.0051
Brugia malayi hypothetical protein 0.002 0.0011 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0024 0.0028
Schistosoma mansoni ran 0.0025 0.0022 0.0025
Loa Loa (eye worm) hypothetical protein 0.039 0.0727 0.084
Loa Loa (eye worm) RNA binding protein 0.0584 0.11 0.1271
Echinococcus multilocularis AMP deaminase 2 0.2505 0.4811 0.4811
Echinococcus granulosus lamin dm0 0.0032 0.0036 0.0041
Toxoplasma gondii AMP deaminase 0.2505 0.4811 0.5554
Trypanosoma brucei trypanothione reductase 0.0053 0.0075 0.0152
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0024 0.0018
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0011 0.0013
Echinococcus multilocularis short transient receptor potential channel 6 0.0076 0.012 0.012
Schistosoma mansoni AMP deaminase 0.2505 0.4811 0.5559
Onchocerca volvulus Glucosylceramidase homolog 0.02 0.036 0.0416
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0027 0.0031
Echinococcus granulosus lysosomal alpha glucosidase 0.0193 0.0345 0.0399
Schistosoma mansoni transient receptor potential channel 0.0076 0.012 0.0138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0246 0.0284
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.004 0.0051 0.0059
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0004 0.0004
Brugia malayi Bromodomain containing protein 0.008 0.0129 0.0149
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0043 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.004 0.0051 0.0051
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0036 0.0041
Loa Loa (eye worm) acetyltransferase 0.0292 0.0538 0.0622
Schistosoma mansoni tar DNA-binding protein 0.0584 0.11 0.1271
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0024 0.0028
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0024 0.0028
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.0124 0.0143
Echinococcus granulosus AMP deaminase 2 0.2505 0.4811 0.5559
Schistosoma mansoni hypothetical protein 0.0181 0.0322 0.0372
Onchocerca volvulus 0.0036 0.0042 0.0049
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0008 0.0013
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0142 0.0155
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0007 0.0008
Echinococcus multilocularis lamin 0.0032 0.0036 0.0036
Schistosoma mansoni glutamate receptor kainate 0.004 0.0051 0.0059
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0008 0.5
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0052 0.0074 0.0086
Onchocerca volvulus 0.0026 0.0024 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0305 0.0563 0.0651
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0038 0.0044
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.4495 0.8655 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0042 0.0049
Brugia malayi MH1 domain containing protein 0.0018 0.0009 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0024 0.0018
Leishmania major importin beta-1 subunit, putative 0.0028 0.0027 0.0028
Echinococcus multilocularis glutamate receptor 2 0.004 0.0051 0.0051
Brugia malayi MH1 domain containing protein 0.0033 0.0038 0.0044
Echinococcus multilocularis glutamate receptor 2 0.0025 0.0022 0.0022
Schistosoma mansoni alpha-glucosidase 0.0166 0.0293 0.0339
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0038 0.0044
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0046 0.0062 0.0071
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.2505 0.4811 0.5558
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0024 0.0028
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0038 0.0044
Loa Loa (eye worm) hypothetical protein 0.1747 0.3348 0.3868
Trypanosoma cruzi ISWI complex protein 0.0015 0.0002 0.0004
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0397 0.0739 0.0854
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0024 0.0018
Echinococcus multilocularis short transient receptor potential channel 6 0.0076 0.012 0.012
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0015 0.0002 0.0002
Onchocerca volvulus 0.0169 0.0299 0.0346
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0036 0.0041
Schistosoma mansoni survival motor neuron protein 0.0106 0.0177 0.0204
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0011 0.0013
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.0056 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.036 0.0416
Brugia malayi Adenosine/AMP deaminase family protein 0.4495 0.8655 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.004 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0211 0.0381 0.044
Echinococcus granulosus survival motor neuron protein 1 0.0517 0.0972 0.1123
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0002 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0036 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0024 0.0026
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Mycobacterium tuberculosis Probable reductase 0.012 0.0206 0.0228
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0142 0.0155
Brugia malayi Muscleblind-like protein 0.0177 0.0314 0.0363
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Echinococcus granulosus glutamate receptor 2 0.004 0.0051 0.0059
Echinococcus granulosus short transient receptor potential channel 6 0.0076 0.012 0.0138
Echinococcus multilocularis geminin 0.107 0.204 0.204
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0022 0.0041
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0004 0.0004
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0005 0.0006
Brugia malayi MH2 domain containing protein 0.0491 0.0921 0.1064
Onchocerca volvulus 0.0032 0.0036 0.0041
Brugia malayi N-terminal motif family protein 0.0397 0.0739 0.0854
Brugia malayi Calcitonin receptor-like protein seb-1 0.0571 0.1076 0.1243
Echinococcus granulosus intermediate filament protein 0.0032 0.0036 0.0041
Echinococcus multilocularis transient receptor potential gamma protein 0.0115 0.0195 0.0195
Echinococcus granulosus segment polarity protein dishevelled 0.002 0.0011 0.0013
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0056 0.0064
Echinococcus multilocularis nmda type glutamate receptor 0.0015 0.0002 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0024 0.0018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0181 0.0322 0.0372
Echinococcus granulosus muscleblind protein 0.0177 0.0314 0.0363
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0011 0.0013
Echinococcus multilocularis musashi 0.0032 0.0036 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0246 0.0284
Echinococcus granulosus TRP transient receptor potential channel 0.0043 0.0056 0.0064
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0008 0.0007
Echinococcus multilocularis segment polarity protein dishevelled 0.002 0.0011 0.0011
Schistosoma mansoni smad1 5 8 and 0.0033 0.0038 0.0044
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.0232 0.0258
Schistosoma mansoni hypothetical protein 0.0036 0.0043 0.005
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0011 0.0013
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.002 0.0011 0.0011
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.2505 0.4811 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.025 0.0455 0.0526
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.0124 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0027 0.0055
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0008 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0056 0.0064
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0008 0.0013
Schistosoma mansoni transient receptor potential channel 4 0.0115 0.0195 0.0225
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0008 0.0018
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.1747 0.3348 0.3867
Echinococcus granulosus Pleckstrin G protein interacting region 0.002 0.0011 0.0013
Brugia malayi TAR-binding protein 0.0584 0.11 0.1271
Brugia malayi glutathione reductase 0.0053 0.0075 0.0087
Loa Loa (eye worm) hypothetical protein 0.0517 0.0972 0.1123
Trichomonas vaginalis glucosylceramidase, putative 0.0305 0.0563 0.0651
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0038 0.0044
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0075 0.0087
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0104 0.0212
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0038 0.0038
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0024 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.036 0.0416
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.0056 0.0064
Trypanosoma cruzi ISWI complex protein 0.0015 0.0002 0.0004
Schistosoma mansoni transient receptor potential channel 0.0115 0.0195 0.0225
Brugia malayi adenosine monophosphate deaminase 0.2505 0.4811 0.5559
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0051 0.0059
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0011 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0074 0.0086
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0007 0.0008
Onchocerca volvulus 0.1747 0.3348 0.3868
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0004 0.0008
Trypanosoma brucei AMP deaminase, putative 0.2505 0.4811 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.0124 0.0134
Echinococcus multilocularis snurportin 1 0.0364 0.0676 0.0676
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0571 0.1076 0.1243
Schistosoma mansoni bromodomain containing protein 0.0069 0.0106 0.0123
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.0056 0.0064
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0584 0.11 0.1271
Echinococcus multilocularis survival motor neuron protein 1 0.0517 0.0972 0.0972
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0246 0.0284
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0004 0.0004
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0015 0.0002 0.0002
Echinococcus multilocularis glutamate receptor 2 0.004 0.0051 0.0051
Brugia malayi Latrophilin receptor protein 2 0.0181 0.0322 0.0372
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0068 0.0104 0.011
Schistosoma mansoni hypothetical protein 0.0106 0.0177 0.0204
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0024 0.0026
Echinococcus multilocularis adenosine deaminase 0.4495 0.8655 0.8655
Loa Loa (eye worm) hypothetical protein 0.0072 0.0112 0.013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0043 0.0043
Echinococcus granulosus geminin 0.107 0.204 0.2357
Trichomonas vaginalis glucosylceramidase, putative 0.0305 0.0563 0.0651
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0016 0.0016
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0016 0.0018
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0011 0.0003
Echinococcus granulosus tumor protein p63 0.0342 0.0633 0.0732
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0039 0.0039
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0002 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0068 0.0104 0.012
Loa Loa (eye worm) hypothetical protein 0.0169 0.0299 0.0346
Loa Loa (eye worm) hypothetical protein 0.0758 0.1436 0.1659
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0005 0.0006
Brugia malayi MH1 domain containing protein 0.0018 0.0009 0.001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.0206 0.0228
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.01 0.0115
Loa Loa (eye worm) hypothetical protein 0.2748 0.5281 0.6101
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0008 0.001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0075 0.0077
Schistosoma mansoni hypothetical protein 0.107 0.204 0.2357
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0015 0.0002 0.0002
Schistosoma mansoni smad1 5 8 and 0.0033 0.0038 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0004
Leishmania major trypanothione reductase 0.0053 0.0075 0.0085
Trichomonas vaginalis adenosine deaminase, putative 0.4495 0.8655 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0004 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0008 0.0018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0181 0.0322 0.0372
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0305 0.0563 0.0651
Loa Loa (eye worm) glutamate receptor 1 0.004 0.0051 0.0059
Schistosoma mansoni alpha glucosidase 0.0043 0.0056 0.0064
Loa Loa (eye worm) hypothetical protein 0.0032 0.0034 0.004
Echinococcus multilocularis lysosomal alpha glucosidase 0.0193 0.0345 0.0345
Brugia malayi RNA binding protein 0.0584 0.11 0.1271
Entamoeba histolytica adenosine deaminase, putative 0.4495 0.8655 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0008 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0104 0.0104
Onchocerca volvulus Huntingtin homolog 0.0145 0.0253 0.0292
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0008 0.0008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0362 0.0672 0.0672
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0046 0.0062 0.0071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0752 0.1426 0.1648
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.0232 0.024
Loa Loa (eye worm) AMP deaminase 0.2505 0.4811 0.5559
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0022 0.0015
Loa Loa (eye worm) transcription factor SMAD2 0.0491 0.0921 0.1064
Trichomonas vaginalis glucosylceramidase, putative 0.0305 0.0563 0.0651
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0069 0.0107 0.0123
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0056 0.0064
Trypanosoma cruzi AMP deaminase, putative 0.2505 0.4811 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0024 0.0018
Entamoeba histolytica Ran family GTPase 0.0025 0.0022 0.0025
Loa Loa (eye worm) hypothetical protein 0.4495 0.8655 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.001
Entamoeba histolytica adenosine deaminase, putative 0.4495 0.8655 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0364 0.0676 0.0781
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0104 0.0216
Loa Loa (eye worm) MH2 domain-containing protein 0.0491 0.0921 0.1064
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.2505 0.4811 0.5558
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0008 0.001
Schistosoma mansoni hypothetical protein 0.0181 0.0322 0.0372
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0008 0.0018
Onchocerca volvulus 0.002 0.0011 0.0013
Brugia malayi PHD-finger family protein 0.0031 0.0034 0.0039
Loa Loa (eye worm) TAR-binding protein 0.0584 0.11 0.1271
Entamoeba histolytica hypothetical protein 0.0036 0.0043 0.005
Schistosoma mansoni tar DNA-binding protein 0.0584 0.11 0.1271
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0104 0.0104
Plasmodium falciparum glutathione reductase 0.0053 0.0075 0.0077
Echinococcus granulosus glutamate NMDA receptor subunit 0.004 0.0051 0.0059

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.72 uM The compound was tested for its ability to block PCP N-methyl-D-aspartate glutamate receptor at the PCP (phencyclidine) binding site in postmortem human frontal cortex. ChEMBL. 9464369
Ki (binding) = 1.72 uM The compound was tested for its ability to block PCP N-methyl-D-aspartate glutamate receptor at the PCP (phencyclidine) binding site in postmortem human frontal cortex. ChEMBL. 9464369

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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