Detailed information for compound 252276

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.387 | Formula: C23H18O3
  • H donors: 0 H acceptors: 2 LogP: 5.08 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Oc1ccc(cc1)/C(=C\c1ccccc1)/C(=O)c1ccccc1
  • InChi: 1S/C23H18O3/c1-17(24)26-21-14-12-19(13-15-21)22(16-18-8-4-2-5-9-18)23(25)20-10-6-3-7-11-20/h2-16H,1H3/b22-16+
  • InChiKey: HJNXUMRHUMFZEB-CJLVFECKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0009 0.0039
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0017 0.0181
Entamoeba histolytica hypothetical protein 0.0071 0.0119 0.1624
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0369 0.0682 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0071 0.0119 0.0596
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0113
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0369 0.0682 0.1874
Mycobacterium ulcerans hypothetical protein 0.007 0.0117 0.2495
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0119 0.0725
Loa Loa (eye worm) hypothetical protein 0.0232 0.0423 0.2608
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0063 0.0062
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0071 0.0119 0.0117
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0208 0.0378 0.0376
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0063 0.0062
Echinococcus granulosus cpg binding protein 0.0027 0.0036 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Brugia malayi hypothetical protein 0.0042 0.0063 0.0382
Onchocerca volvulus 0.0042 0.0063 0.0335
Onchocerca volvulus 0.0042 0.0063 0.0335
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0863 0.1617 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0028 0.0225
Brugia malayi AKH receptor 0.0042 0.0063 0.0382
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0071 0.0119 0.1624
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0119 0.0725
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0013 0.0009 0.0074
Brugia malayi beta-lactamase family protein 0.007 0.0117 0.0712
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0071 0.0119 0.0328
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0119 0.1624
Brugia malayi glutathione reductase 0.0049 0.0078 0.0471
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0211
Echinococcus granulosus expressed protein 0.0035 0.005 0.0049
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.002 0.0044
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0041 0.0246
Loa Loa (eye worm) phosphatidylinositol 3 0.0071 0.0119 0.0725
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0017 0.0683
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0078 0.0076
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0063 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Leishmania major DNA polymerase kappa, putative 0.0019 0.002 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0063 0.0062
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0369 0.0682 0.1946
Echinococcus multilocularis dna polymerase eta 0.0019 0.002 0.0018
Mycobacterium ulcerans hypothetical protein 0.0023 0.0028 0.043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0119 0.0725
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0071 0.0119 0.0596
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0071 0.0119 0.1685
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0009 0.0065
Brugia malayi hypothetical protein 0.0042 0.0063 0.0382
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0197 0.2289
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0219 0.0903
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0086 0.0421
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0063 0.026
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Giardia lamblia Kinase, PLK 0.0109 0.0191 0.2695
Leishmania major phosphatidylinositol 3-kinase, putative 0.0369 0.0682 0.1874
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0163
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0028 0.0274
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0191 0.1171
Schistosoma mansoni neuropeptide receptor 0.0042 0.0063 0.026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0063 0.0382
Plasmodium falciparum glutathione reductase 0.0049 0.0078 0.5975
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.0378 0.2011
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0208 0.0378 0.233
Echinococcus granulosus lamin 0.0056 0.0091 0.0089
Leishmania major trypanothione reductase 0.0049 0.0078 0.0202
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0017 0.0169
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0009 0.0039
Onchocerca volvulus 0.0042 0.0063 0.0335
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0063 0.0062
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0117 0.0712
Onchocerca volvulus 0.0042 0.0063 0.0335
Brugia malayi putative neuropeptide receptor 0.0042 0.0063 0.0382
Mycobacterium tuberculosis Conserved protein 0.007 0.0117 0.1308
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0063 0.026
Echinococcus granulosus neuropeptide s receptor 0.0042 0.0063 0.0062
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0071 0.0119 0.0328
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.002 0.0127
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0117 0.0585
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0071 0.0119 0.0117
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0117 0.1308
Onchocerca volvulus 0.0023 0.0028 0.0143
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0063 0.0382
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0071 0.0119 0.1685
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0063 0.026
Schistosoma mansoni coup transcription factor 0.0009 0.0002 0.0006
Echinococcus multilocularis transcription factor Dp 1 0.004 0.006 0.0058
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0369 0.0682 0.1874
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0095
Schistosoma mansoni biogenic amine (5HT) receptor 0.0295 0.0542 0.223
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0071 0.0119 0.0488
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.0301 0.1853
Echinococcus granulosus orexin receptor type 2 0.0042 0.0063 0.0062
Echinococcus multilocularis 0.0071 0.0119 0.0117
Echinococcus granulosus histone acetyltransferase KAT2B 0.0163 0.0292 0.0291
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.024 0.0439 0.0438
Loa Loa (eye worm) beta-lactamase 0.007 0.0117 0.0712
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0114 0.0113
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0063 0.0062
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0028 0.043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0219 0.3173
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.002 0.0042
Echinococcus multilocularis serotonin receptor 0.0295 0.0542 0.0541
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0009 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0191 0.0989
Brugia malayi G-protein coupled receptor 0.0042 0.0063 0.0382
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0114 0.0304
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0191 0.0515
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0161 0.0289 0.0287
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0219 0.0218
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0071 0.0119 0.0596
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0071 0.0119 0.0488
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.002 0.0227
Mycobacterium ulcerans aldehyde dehydrogenase 0.024 0.0439 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0369 0.0682 0.1874
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Echinococcus granulosus g protein coupled receptor 0.0042 0.0063 0.0062
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0071 0.0119 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0017 0.0035
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0071 0.0119 0.0328
Echinococcus granulosus g protein coupled receptor 0.0042 0.0063 0.0062
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0063 0.0062
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0063 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.002 0.0113
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0071 0.0119 0.0328
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0071 0.0119 0.0596
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0002 0.0006
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0063 0.0062
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0017 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0101 0.0413
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.002 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.1852 0.3487 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0017 0.0068
Onchocerca volvulus 0.0042 0.0063 0.0335
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.002 0.0081
Brugia malayi aldehyde dehydrogenase 0.0013 0.0009 0.0049
Brugia malayi sulfakinin receptor protein 0.0042 0.0063 0.0382
Treponema pallidum NADH oxidase 0.0017 0.0017 1
Schistosoma mansoni lamin 0.0056 0.0091 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0227
Brugia malayi Dopamine receptor protein 2 0.0042 0.0063 0.0382
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0017 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0369 0.0682 0.2806
Echinococcus granulosus GPCR family 2 0.0015 0.0013 0.0012
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0191 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Onchocerca volvulus 0.0071 0.0119 0.0636
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0063 0.0382
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0369 0.0682 0.2806
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Schistosoma mansoni hypothetical protein 0.0042 0.0063 0.026
Schistosoma mansoni amine GPCR 0.0042 0.0063 0.026
Echinococcus granulosus allatostatin A receptor 0.0042 0.0063 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.0301 0.1238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0219 0.0903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0063 0.026
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0028 0.0065
Schistosoma mansoni cpg binding protein 0.0027 0.0036 0.0149
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0063 0.0382
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0071 0.0119 1
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0119 0.5367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0101 0.0613
Schistosoma mansoni opsin-like receptor 0.0042 0.0063 0.026
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0063 0.0382
Brugia malayi FAT domain containing protein 0.0161 0.0289 0.1777
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0017 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0244 0.1278
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.005 0.0223
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0077 0.3476
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0063 0.0062
Schistosoma mansoni myosin xvIII 0.0042 0.0063 0.026
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0063 0.0382
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0071 0.0119 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0119 0.1624
Echinococcus granulosus histone lysine methyltransferase setb 0.0124 0.0219 0.0218
Brugia malayi RNA binding protein 0.0061 0.0101 0.0613
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0015 0.0069
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0063 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0063 0.026
Schistosoma mansoni aldehyde dehydrogenase 0.024 0.0439 0.1806
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.024 0.0439 0.5242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0119 0.0596
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0002 0.0006
Echinococcus multilocularis expressed protein 0.0035 0.005 0.0049
Brugia malayi Aldehyde dehydrogenase protein 4 0.0013 0.0009 0.0049
Entamoeba histolytica hypothetical protein 0.0071 0.0119 0.1624
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Onchocerca volvulus 0.0124 0.0219 0.1184
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0015 0.0069
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0049 0.0653
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0071 0.0119 0.0596
Trypanosoma brucei trypanothione reductase 0.0049 0.0078 0.108
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0009 0.0014
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0101 0.0613
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0071 0.0119 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0227
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Schistosoma mansoni hypothetical protein 0.0071 0.0119 0.0488
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Toxoplasma gondii aldehyde dehydrogenase 0.024 0.0439 0.6413
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0063 0.0382
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0114 0.1562
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0063 0.026
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0017 0.0169
Brugia malayi Pre-SET motif family protein 0.0863 0.1617 1
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0017 0.004
Onchocerca volvulus 0.0042 0.0063 0.0335
Brugia malayi beta-lactamase family protein 0.007 0.0117 0.0712
Schistosoma mansoni amine GPCR 0.0042 0.0063 0.026
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0017 0.0091
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0028 0.0163
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0009 0.0039
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0191 0.0989
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0101 0.0099
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.0301 0.0299
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0197 0.8877
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0028 0.0274
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0161 0.0289 0.0287
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0009 0.0014
Onchocerca volvulus 0.007 0.0117 0.0625
Brugia malayi Serotonin receptor 0.0042 0.0063 0.0382
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0191 0.0189
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0005 0.0004
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0008 0.004
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0101 0.0413
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0063 0.0382
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0062 0.0061
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0071 0.0119 0.0488
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0055
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0369 0.0682 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.002 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0191 0.0989
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0063 0.0382
Echinococcus multilocularis lamin 0.0056 0.0091 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0028 0.043
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0117 0.0585
Mycobacterium leprae Probable lipase LipE 0.007 0.0117 0.5072
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0221 0.2578
Echinococcus granulosus dnaJ subfamily B 0.037 0.0684 0.0683
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0063 0.0062
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0191 0.0989
Echinococcus granulosus serotonin receptor 0.0042 0.0063 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0232 0.0423 0.2256
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0117 0.0712
Schistosoma mansoni cpg binding protein 0.0027 0.0036 0.0149
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0063 0.0382
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0725
Mycobacterium ulcerans lipase LipD 0.007 0.0117 0.2495
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0017 0.0035
Onchocerca volvulus 0.007 0.0117 0.0625
Schistosoma mansoni neuropeptide receptor 0.0042 0.0063 0.026
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0117 0.1308
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0071 0.0119 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.007 0.0117 0.0712
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0191 0.0784
Onchocerca volvulus 0.0042 0.0063 0.0335
Trypanosoma brucei polo-like protein kinase 0.0109 0.0191 0.2749
Loa Loa (eye worm) hypothetical protein 0.0124 0.0219 0.1349
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0017 0.0035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0063 0.026
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0077 0.1078
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0071 0.0119 0.1685
Leishmania major hypothetical protein, conserved 0.1923 0.3622 1
Schistosoma mansoni neuropeptide receptor 0.0042 0.0063 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0119 0.0596
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0119 0.021 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0071 0.0119 0.0117
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0063 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0119 0.0596
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0071 0.0119 0.1624
Mycobacterium ulcerans aldehyde dehydrogenase 0.024 0.0439 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0028 0.0225
Schistosoma mansoni amine GPCR 0.0042 0.0063 0.026
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0013 0.0009 0.0074
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0009 0.0074
Onchocerca volvulus 0.0042 0.0063 0.0335
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0119 0.5168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.0378 0.2011
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0008 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0227
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0078 0.021
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0017 0.0108
Echinococcus granulosus dna polymerase kappa 0.0019 0.002 0.0018
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0017 0.0034
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0049 0.0653
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0063 0.0062
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0071 0.0119 0.0117
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0208 0.0378 0.5511
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0063 0.026
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0013 0.0009 0.0039
Echinococcus granulosus sex peptide receptor 0.0042 0.0063 0.0062
Schistosoma mansoni hypothetical protein 0.012 0.0211 0.0868
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0071 0.0119 0.1685
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0013 0.0012
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0063 0.0062
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0117 0.0585
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0073
Brugia malayi hypothetical protein 0.0042 0.0063 0.0382
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0063 0.0062
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0076 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0227
Echinococcus granulosus somatostatin receptor 0.0042 0.0063 0.0062
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0017 0.0181
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0117 0.1308
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0013 0.0009 0.0074
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0063 0.0062
Brugia malayi hypothetical protein 0.0042 0.0063 0.0382
Onchocerca volvulus 0.0042 0.0063 0.0335
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0013 0.0009 0.0074
Schistosoma mansoni hypothetical protein 0.0042 0.0063 0.026
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0114 0.0316
Loa Loa (eye worm) hypothetical protein 0.0033 0.0047 0.0281
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0002 0.0006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0101 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0232 0.0423 0.2256
Schistosoma mansoni histamine h1 receptor 0.0042 0.0063 0.026
Echinococcus multilocularis microtubule associated protein 2 0.1293 0.2431 0.243
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0124 0.0219 0.0218
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0369 0.0682 0.4214
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0076 0.046
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0063 0.026
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0063 0.026
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0197 0.2289
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0028 0.043
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0071 0.0119 0.0117
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0041 0.0246
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0044
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0063 0.0062
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0063 0.026
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0017 0.0035
Brugia malayi larval opioid receptor 0.0042 0.0063 0.0382
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0101 0.0413
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0028 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0095
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0221 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Plasmodium vivax glutathione reductase, putative 0.0049 0.0078 0.3482
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0013 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Loa Loa (eye worm) phosphatidylinositol 3 0.0369 0.0682 0.4214
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0117 0.0115
Loa Loa (eye worm) hypothetical protein 0.0056 0.0091 0.0552
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0062 0.0255
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Schistosoma mansoni opsin-like receptor 0.0042 0.0063 0.026
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0369 0.0682 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0117 0.0712
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0017 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0017 0.0035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.0378 0.2011
Onchocerca volvulus 0.0042 0.0063 0.0335
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0117 0.2495
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0071 0.0119 0.0488
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0002 0.0006
Brugia malayi GnHR receptor homolog 0.0042 0.0063 0.0382
Echinococcus granulosus fmrfamide receptor 0.0042 0.0063 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0044
Leishmania major phosphatidylinositol kinase related protein, putative 0.0071 0.0119 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0062 0.0255
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0071 0.0119 0.1685
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0063 0.0062
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0034 0.0198
Schistosoma mansoni biogenic amine receptor 0.0042 0.0063 0.026
Mycobacterium tuberculosis Conserved protein 0.007 0.0117 0.1308
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0013 0.0009 0.0074
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0063 0.0382
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0062 0.0255
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0095
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0208 0.0378 0.1072
Echinococcus granulosus neuropeptide receptor 0.0042 0.0063 0.0062
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0063 0.026
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0078 0.0832
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0009 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0071 0.0119 0.1685
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0094 0.132
Echinococcus granulosus dna polymerase eta 0.0019 0.002 0.0018
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.002 0.0018
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0369 0.0682 0.0681
Brugia malayi CXXC zinc finger family protein 0.0026 0.0034 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0227
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0063 0.026
Mycobacterium ulcerans aldehyde dehydrogenase 0.024 0.0439 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0725
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0013 0.0009 0.0049
Echinococcus multilocularis somatostatin receptor 0.0042 0.0063 0.0062
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0071 0.0119 0.1624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0013 0.0009 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.0378 0.2011
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0232 0.0423 0.6174
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0077 0.0371
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0028 0.043
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0197 0.2289
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0013 0.0009 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0117 0.0322
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0013 0.0009 0.0049
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0002 0.0006
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.002 0.0227
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0063 0.026
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0208 0.0378 0.0376
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.0063 0.0062
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0208 0.0378 0.5478
Schistosoma mansoni hypothetical protein 0.0161 0.0289 0.1187
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0071 0.0119 0.0596
Leishmania major phosphatidylinositol 3-kinase, putative 0.0071 0.0119 0.0316
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0063 0.0062
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0071 0.0119 0.1685
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0017 0.0181
Schistosoma mansoni cpg binding protein 0.0026 0.0034 0.0138
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0369 0.0682 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Loa Loa (eye worm) hypothetical protein 0.0055 0.0089 0.054
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0013 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0063 0.0062
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0013 0.0009 0.0043
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0119 0.1624
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Echinococcus multilocularis allatostatin A receptor 0.0042 0.0063 0.0062
Schistosoma mansoni adenoreceptor 0.0042 0.0063 0.026
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0232 0.0423 0.6174
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0078 0.0471
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0017 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0063 0.026
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0009 0.0039
Echinococcus granulosus tar DNA binding protein 0.0061 0.0101 0.0099
Onchocerca volvulus 0.0042 0.0063 0.0335
Schistosoma mansoni amine GPCR 0.0042 0.0063 0.026
Entamoeba histolytica hypothetical protein 0.0071 0.0119 0.1624
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0191 0.0989
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.002 0.0018
Trichomonas vaginalis rotamase, putative 0.0035 0.005 0.0223
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.0063 0.0335
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0114 0.0699
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0013 0.0009 0.0008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0028 0.0274
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0071 0.0119 0.0488
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0101 0.0413
Schistosoma mansoni hypothetical protein 0.0013 0.0009 0.0039
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0009 0.0014
Echinococcus granulosus intermediate filament protein 0.0056 0.0091 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.0378 0.2011
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0063 0.0062
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0063 0.0062
Echinococcus granulosus serine protein kinase ATM 0.0208 0.0378 0.0376
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0199
Leishmania major hypothetical protein, unknown function 0.0071 0.0119 0.0316
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0017 0.0035
Onchocerca volvulus 0.0026 0.0034 0.0174
Brugia malayi intermediate filament protein 0.0056 0.0091 0.0552
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0062 0.0061
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0447 0.0829 1
Trypanosoma brucei unspecified product 0.0013 0.0009 0.0065
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Trypanosoma brucei unspecified product 0.0019 0.002 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0071 0.0119 0.0488
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0117 0.0322
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0114 0.1625
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Brugia malayi ORL1-like opioid receptor 0.0042 0.0063 0.0382
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0071 0.0119 0.0328
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.0063 0.0062
Mycobacterium tuberculosis Conserved hypothetical protein 0.0071 0.0119 0.1333
Brugia malayi Dopamine receptor protein 1 0.0042 0.0063 0.0382
Mycobacterium ulcerans beta-lactamase 0.007 0.0117 0.2495
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0063 0.026
Loa Loa (eye worm) phosphatidylinositol kinase 0.0071 0.0119 0.0725
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0009 0.0039
Toxoplasma gondii ABC1 family protein 0.007 0.0117 0.1655
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.0063 0.0062
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0002 0.0006
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0063 0.0062
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0009 0.0014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0013 0.0012
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0071 0.0119 0.0725
Onchocerca volvulus 0.0056 0.0091 0.0484
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0017 0.0691
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Schistosoma mansoni hypothetical protein 0.0042 0.0063 0.026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0095
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0369 0.0682 1
Schistosoma mansoni hypothetical protein 0.0042 0.0063 0.026
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0005 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0191 0.0989
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0028 0.0065
Brugia malayi hypothetical protein 0.0042 0.0063 0.0382
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0017 0.0181
Onchocerca volvulus 0.0042 0.0063 0.0335
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0028 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0063 0.026
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0227
Loa Loa (eye worm) hypothetical protein 0.007 0.0117 0.0712
Schistosoma mansoni neuropeptide receptor 0.0042 0.0063 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.024 0.0439 0.0438
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0369 0.0682 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.002 0.0154
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0369 0.0682 0.1946
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0071 0.0119 0.0596
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0117 0.1308
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0028 0.043
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0071 0.0119 0.0117
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0013 0.0009 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Plasmodium falciparum thioredoxin reductase 0.0049 0.0078 0.5975
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0044
Trypanosoma cruzi target of rapamycin kinase 3 0.0369 0.0682 0.1946
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0227
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0063 0.0062
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0208 0.0378 0.233
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0191 0.0989
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Schistosoma mansoni microtubule-associated protein tau 0.1293 0.2431 1
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0013 0.0009 0.0014
Brugia malayi hypothetical protein 0.0042 0.0063 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0119 0.0725
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0009 0.0014
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0017 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0244 0.1499
Brugia malayi Serotonin receptor 0.0042 0.0063 0.0382
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0063 0.0062
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0005 0.0004
Echinococcus multilocularis musashi 0.0056 0.0091 0.0089
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0063 0.026
Leishmania major DNA polymerase eta, putative 0.0019 0.002 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0062 0.0061
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0013 0.0009 0.0074
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0063 0.0062
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0049
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0015 0.0069
Brugia malayi Pre-SET motif family protein 0.0124 0.0219 0.1349
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0063 0.0062
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.007 0.0897
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0369 0.0682 0.0681
Loa Loa (eye worm) acetyltransferase 0.0167 0.0301 0.1853
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0017 0.0035
Loa Loa (eye worm) phosphatidylinositol 3 0.0071 0.0119 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.0289 0.1523
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Onchocerca volvulus 0.0982 0.1842 1
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0009 0.0014
Schistosoma mansoni hypothetical protein 0.0033 0.0047 0.0193
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0063 0.026
Loa Loa (eye worm) hypothetical protein 0.0048 0.0076 0.046
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0063 0.0382
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0071 0.0119 0.1685
Brugia malayi Melatonin receptor type 1A 0.0042 0.0063 0.0382
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0013 0.0009 0.0008
Plasmodium vivax SET domain protein, putative 0.0124 0.0219 1
Toxoplasma gondii thioredoxin reductase 0.0049 0.0078 0.108
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.0071 0.0119 0.1624
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0063 0.0062
Onchocerca volvulus 0.0042 0.0063 0.0335
Mycobacterium tuberculosis Conserved protein 0.007 0.0117 0.1308
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0071 0.0119 0.5367
Brugia malayi G-protein coupled receptor 0.0042 0.0063 0.0382
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0197 0.2289
Leishmania major phosphatidylinositol 4-kinase, putative 0.0071 0.0119 0.0316
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.0063 0.0335
Brugia malayi hypothetical protein 0.0042 0.0063 0.0382
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0227
Brugia malayi G protein-coupled receptor 0.0042 0.0063 0.0382
Plasmodium vivax hypothetical protein, conserved 0.007 0.0117 0.5274
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0227
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0063 0.026
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0197 0.2289
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.002 0.0227
Schistosoma mansoni amine GPCR 0.0042 0.0063 0.026
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0055
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0071 0.0119 0.0316
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0071 0.0119 0.0117
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.007 0.0897
Onchocerca volvulus 0.0071 0.0119 0.0636
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0013 0.0009 0.0049
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0208 0.0378 0.1554
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0063 0.0062
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0002 0.0006
Echinococcus multilocularis lamin dm0 0.0056 0.0091 0.0089
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0063 0.026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.002 0.0044
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0117 0.1308
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0063 0.0062
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.5295 1 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0071 0.0119 0.1624
Onchocerca volvulus 0.007 0.0117 0.0625
Echinococcus multilocularis Zinc finger, PHD finger 0.0071 0.0119 0.0117
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.005 0.0301
Brugia malayi hypothetical protein 0.0042 0.0063 0.0382
Schistosoma mansoni biogenic amine receptor 0.0042 0.0063 0.026
Schistosoma mansoni rotamase 0.0035 0.005 0.0206
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0369 0.0682 0.1946
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0015 0.0069
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.0063 0.0062
Brugia malayi neuropeptide F receptor 0.0042 0.0063 0.0382
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0369 0.0682 1
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0063 0.0062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0097 0.04
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0013 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0013 0.0073
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0071 0.0119 0.5367
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0013 0.0073
Brugia malayi RE15519p 0.0042 0.0063 0.0382
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0063 0.0062
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0117 0.1655
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0071 0.0119 0.0328
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.007 0.0117 0.0712
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0055
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0071 0.0119 0.1685
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0071 0.0119 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0063 0.026
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0063 0.0062
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0063 0.0382
Schistosoma mansoni fkbp-rapamycin associated protein 0.0208 0.0378 0.1554
Onchocerca volvulus 0.0042 0.0063 0.0335
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Giardia lamblia GTOR 0.0369 0.0682 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0063 0.0062
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0013 0.0009 0.0049
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0063 0.0062
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0013 0.0009 0.0074
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0013 0.0009 0.0039
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0071 0.0119 0.0596
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0049 0.0127
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0063 0.0062
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0071 0.0119 0.0328
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0119 0.0725
Loa Loa (eye worm) RNA binding protein 0.0061 0.0101 0.0613
Schistosoma mansoni lamin 0.0056 0.0091 0.0373
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0071 0.0119 0.5367
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0028 0.043
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.002 0.0113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0117 0.0479
Loa Loa (eye worm) glutathione reductase 0.0049 0.0078 0.0471
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0063 0.0062
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0013 0.0009 0.0008
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0063 0.0062
Loa Loa (eye worm) phosphatidylinositol 3 0.0071 0.0119 0.0725
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0063 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0017 0.0015
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0063 0.026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Echinococcus multilocularis dnaJ subfamily B 0.037 0.0684 0.0683
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0013 0.0012
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0063 0.0382
Onchocerca volvulus 0.0042 0.0063 0.0335
Loa Loa (eye worm) hypothetical protein 0.0295 0.0542 0.3346
Toxoplasma gondii FATC domain-containing protein 0.0208 0.0378 0.5511
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0114 0.0316
Echinococcus multilocularis sex peptide receptor 0.0042 0.0063 0.0062
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.002 0.0057
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0017 0.0181
Loa Loa (eye worm) aldehyde dehydrogenase 0.0013 0.0009 0.0049
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0009 0.0014
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0071 0.0119 0.0117
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.007 0.0117 0.0712
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0077 0.0371
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.0063 0.0382
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0063 0.0382
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0369 0.0682 0.0681
Echinococcus granulosus transcription factor Dp 1 0.004 0.006 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Mycobacterium leprae conserved hypothetical protein 0.007 0.0117 0.5072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0017 0.0035
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0063 0.0062
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0055
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0047 0.0281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0063 0.026
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.002 0.0127
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0221 0.2578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0049 0.0127
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0009 0.0014
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0008 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.0378 0.2011
Schistosoma mansoni hypothetical protein 0.037 0.0684 0.2816
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0009 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Onchocerca volvulus 0.0042 0.0063 0.0335
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0221 0.2578
Schistosoma mansoni intermediate filament proteins 0.0056 0.0091 0.0373
Loa Loa (eye worm) hypothetical protein 0.007 0.0117 0.0712
Echinococcus granulosus neuropeptide receptor 0.0042 0.0063 0.0062
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0049 0.0122
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0063 0.026
Toxoplasma gondii target of rapamycin (TOR), putative 0.0369 0.0682 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0017 0.0034
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0071 0.0119 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.0244 0.1278
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0036 0.0034
Brugia malayi follicle stimulating hormone receptor 0.0042 0.0063 0.0382
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0009 0.0014
Brugia malayi neuropeptide F receptor 0.0042 0.0063 0.0382
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0062 0.0061
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.002 0.0154
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0117 0.1308
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.002 0.0241
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0063 0.0062
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0063 0.0382
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0077 0.1078
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0095
Trichomonas vaginalis set domain proteins, putative 0.0982 0.1842 1
Schistosoma mansoni opsin-like receptor 0.0042 0.0063 0.026
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0191 0.0535
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0071 0.0119 0.0725
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0078 0.0076
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0091 0.0552
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0114 0.0113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0117 0.0479
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0002 0.0006
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0078 0.3482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0063 0.026
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0119 0.1624
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.002 0.0081
Schistosoma mansoni biogenic amine receptor 0.0042 0.0063 0.026
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0101 0.0413
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0071 0.0119 0.1624
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0071 0.0119 0.0117
Trichomonas vaginalis esterase, putative 0.007 0.0117 0.0585
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Echinococcus granulosus g protein coupled receptor 0.0042 0.0063 0.0062
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0028 0.0065
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.002 0.0113
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0002 0.0006
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0013 0.0009 0.0008
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0028 0.043
Loa Loa (eye worm) hypothetical protein 0.0295 0.0542 0.3346
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0062 0.0375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.0378 0.2011
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0017 0.0089
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0008 0.0041
Trypanosoma brucei unspecified product 0.0013 0.0009 0.0065
Giardia lamblia Phosphatidylinositol 4-kinase 0.0071 0.0119 0.1624
Loa Loa (eye worm) phosphatidylinositol 3 0.0369 0.0682 0.4214
Trypanosoma brucei RNA helicase, putative 0.012 0.0211 0.3049
Onchocerca volvulus 0.0056 0.0091 0.0484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0219 0.0903
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0076 0.046
Brugia malayi hypothetical protein 0.0042 0.0063 0.0382
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0063 0.0062
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0369 0.0682 0.4214
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0124 0.0219 0.0903
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0063 0.0062
Giardia lamblia Hypothetical protein 0.0071 0.0119 0.1624
Brugia malayi TAR-binding protein 0.0061 0.0101 0.0613
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0199
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0063 0.0062
Echinococcus multilocularis GPCR, family 2 0.0015 0.0013 0.0012
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.002 0.0241
Mycobacterium tuberculosis Probable reductase 0.0112 0.0197 0.2289
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0028 0.0873
Entamoeba histolytica hypothetical protein 0.0208 0.0378 0.5478
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0117 0.0585
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0191 0.1027
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0062 0.0375
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0117 0.0585
Brugia malayi Thioredoxin reductase 0.0049 0.0078 0.0471
Echinococcus granulosus biogenic amine 5HT receptor 0.0295 0.0542 0.0541
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0028 0.0873
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0071 0.0119 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0117 0.2495
Echinococcus granulosus lamin dm0 0.0056 0.0091 0.0089
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0117 0.1308
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0017 0.0034
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0063 0.0062
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0119 0.0725
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0071 0.0119 0.0596
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0208 0.0378 0.233
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0369 0.0682 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0071 0.0119 0.0725
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Echinococcus granulosus hypothetical protein 0.0042 0.0063 0.0062
Echinococcus multilocularis serine protein kinase ATM 0.0208 0.0378 0.0376
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0063 0.0062
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0017 0.0035
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0091 0.0552
Echinococcus granulosus microtubule associated protein 2 0.1293 0.2431 0.243
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0063 0.0062
Echinococcus multilocularis serotonin receptor 0.0295 0.0542 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0013 0.0009 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.024 0.0439 0.1806
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0017 0.0683
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0017 0.0094
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0191 0.2695
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0013 0.0009 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0071 0.0119 0.1685
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0017 0.0181
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0086 0.0421
Leishmania major hypothetical protein, conserved 0.007 0.0117 0.031
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0071 0.0119 0.0596
Loa Loa (eye worm) phosphatidylinositol 3 0.0071 0.0119 0.0725
Brugia malayi Dopamine receptor 0.0042 0.0063 0.0382
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0071 0.0119 0.0117
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.005 0.0301
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0013 0.0012
Trichomonas vaginalis rotamase, putative 0.0034 0.0049 0.0214
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0013 0.0009 0.0014
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0191 0.0535
Loa Loa (eye worm) hypothetical protein 0.0161 0.0289 0.1777
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0071 0.0119 0.5367
Brugia malayi beta-lactamase 0.007 0.0117 0.0712
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0077 0.0076
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0063 0.0062
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0063 0.0062
Onchocerca volvulus 0.0042 0.0063 0.0335
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0369 0.0682 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0071 0.0119 0.0117
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.007 0.5202
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0382
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.002 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0002 0.0006
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0063 0.0062
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0137 0.0244 0.0687
Echinococcus multilocularis dna polymerase kappa 0.0019 0.002 0.0018
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0071 0.0119 0.0596
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0191 0.1171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Brugia malayi hypothetical protein 0.0042 0.0063 0.0382
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0063 0.0382
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0071 0.0119 0.0328
Entamoeba histolytica protein kinase rad3, putative 0.0208 0.0378 0.5478
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0369 0.0682 0.1946
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0017 0.0034
Schistosoma mansoni kinase 0.0055 0.0089 0.0367
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.002 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.0378 0.2011
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0114 0.0471
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0091 0.0552
Plasmodium vivax hypothetical protein 0.0071 0.0119 0.5367
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0063 0.026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0049
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0071 0.0119 0.0328
Echinococcus multilocularis cpg binding protein 0.0027 0.0036 0.0035
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0063 0.0062
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0049 0.0584
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.024 0.0439 0.1202
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0009 0.0014
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0208 0.0378 0.1072
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0013 0.0009 0.4071
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0114 0.0699
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0017 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0682 0.3671
Leishmania major phosphatidylinositol kinase, putative 0.0071 0.0119 0.0316
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0117 0.0115
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0071 0.0119 0.1624

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 20 % Percentage inhibition of uterotrophic effects of estradiol in vivo following 100 ug i.p. ChEMBL. 3981542
Inhibition (functional) = 20 % Percentage inhibition of uterotrophic effects of estradiol in vivo following 100 ug i.p. ChEMBL. 3981542
RBA (binding) = 0.28 Relative binding affinity calculated as the ratio of molar concentration of Estrogen receptor beta ChEMBL. 3981542
Uterine weight (functional) = 4.2 mg In vivo uterotrophic activity (uterine weight) in immature mice. ChEMBL. 3981542
Uterine weight (functional) = 4.2 mg In vivo uterotrophic activity (uterine weight) in immature mice. ChEMBL. 3981542
Uterine weight (functional) = 21.5 mg In vivo anti-uterotrophic activity in mice following 1 ug estradiol i.p. ChEMBL. 3981542
Uterine weight (functional) = 21.5 mg In vivo anti-uterotrophic activity in mice following 1 ug estradiol i.p. ChEMBL. 3981542

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.