Detailed information for compound 252585

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 410.466 | Formula: C22H26N4O4
  • H donors: 3 H acceptors: 2 LogP: -0.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(c1ccc(cc1)O[C@@H]1CNCC1)Oc1ccc2c(c1)CN(CC2)C(=N)N
  • InChi: 1S/C22H26N4O4/c23-22(24)26-10-8-14-1-6-18(11-16(14)13-26)30-20(21(27)28)15-2-4-17(5-3-15)29-19-7-9-25-12-19/h1-6,11,19-20,25H,7-10,12-13H2,(H3,23,24)(H,27,28)/t19-,20?/m0/s1
  • InChiKey: GXQXCSXSNUMKJD-XJDOXCRVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References
Homo sapiens protease, serine, 2 (trypsin 2) References
Homo sapiens protease, serine, 1 (trypsin 1) References
Homo sapiens plasminogen Starlite/ChEMBL References
Homo sapiens protease, serine, 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Trypsin family protein protease, serine, 1 (trypsin 1) 247 aa 287 aa 21.6 %
Schistosoma mansoni cercarial elastase (S01 family) protease, serine, 3 261 aa 234 aa 25.2 %
Schistosoma mansoni cercarial elastase (S01 family) protease, serine, 2 (trypsin 2) 247 aa 240 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0085 0.0188 0.3174
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0049 0.0087 0.1308
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0029 0.0083
Schistosoma mansoni inositol transporter 0.0032 0.0042 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0113 0.0329
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0087 0.1333
Schistosoma mansoni hypothetical protein 0.011 0.0257 0.075
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0257 0.214
Onchocerca volvulus 0.0348 0.0918 0.7676
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0029 0.0083
Mycobacterium ulcerans acetyl-CoA synthetase 0.0025 0.0021 0.0335
Brugia malayi nuclear hormone receptor 0.0028 0.0029 0.0275
Loa Loa (eye worm) MH2 domain-containing protein 0.0206 0.0525 0.502
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0158
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0142 0.0347 0.0345
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.0147 0.0145
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0113 0.1736
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0025 0.0021 0.0057
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0049 0.0087 0.0713
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0029 0.0275
Echinococcus multilocularis solute carrier family 5 0.0032 0.0042 0.004
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0049 0.0087 0.1308
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0049 0.0087 0.0713
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0012 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.0392 0.3268
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0025 0.0021 0.0736
Loa Loa (eye worm) hypothetical protein 0.0085 0.0188 0.1798
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3621 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0049 0.0087 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0002 0.0001
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0029 0.0083
Loa Loa (eye worm) hypothetical protein 0.007 0.0147 0.1405
Echinococcus granulosus sodium:glucose cotransporter 2 0.0032 0.0042 0.004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.0002 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0012 0.0011
Echinococcus granulosus neuropeptide s receptor 0.0431 0.1148 0.1146
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0029 0.0027
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0032 0.0042 0.004
Onchocerca volvulus 0.0049 0.0087 0.0727
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0029 0.0033 0.0031
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0025 0.0021 0.0736
Brugia malayi Trypsin family protein 0.0029 0.0033 0.0311
Onchocerca volvulus Glucosylceramidase homolog 0.0157 0.0388 0.3241
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0002 0.0001
Echinococcus granulosus microtubule associated protein 2 0.1252 0.3426 0.3425
Trypanosoma brucei glucosidase, putative 0.0032 0.0041 0.0608
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.006 0.0119 0.4383
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0041 0.0331
Schistosoma mansoni acetyl-CoA synthetase 0.0025 0.0021 0.0062
Echinococcus granulosus Mastin 0.0029 0.0033 0.0031
Leishmania major 4-coumarate:coa ligase-like protein 0.0085 0.0188 0.0517
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0025 0.0021 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0347 0.2891
Brugia malayi hypothetical protein 0.0035 0.0048 0.0459
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0025 0.0021 0.0441
Brugia malayi Trypsin family protein 0.0029 0.0033 0.0311
Schistosoma mansoni hypothetical protein 0.0049 0.0087 0.0253
Loa Loa (eye worm) oxidoreductase 0.0025 0.0021 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0029 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0347 0.2891
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0085 0.0188 0.3174
Plasmodium falciparum acyl-CoA synthetase 0.0063 0.0128 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0087 0.1333
Echinococcus multilocularis enteropeptidase 0.0029 0.0033 0.0031
Toxoplasma gondii aldehyde dehydrogenase 0.0114 0.0269 0.4119
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0029 0.0083
Schistosoma mansoni microtubule-associated protein tau 0.1252 0.3426 1
Brugia malayi Sodium:solute symporter family protein 0.0032 0.0042 0.0399
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0049 0.0087 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0029 0.0275
Toxoplasma gondii histone lysine methyltransferase SET1 0.0154 0.0379 0.581
Echinococcus multilocularis 0.0049 0.0087 0.0085
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0033 0.0094
Brugia malayi hypothetical protein 0.0029 0.0033 0.0311
Onchocerca volvulus 0.0025 0.0021 0.018
Schistosoma mansoni zinc finger protein 0.0021 0.001 0.0029
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0021 0.0736
Echinococcus granulosus neutral alpha glucosidase AB 0.0032 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0275
Brugia malayi Trypsin family protein 0.0348 0.0918 0.878
Schistosoma mansoni fkbp-rapamycin associated protein 0.0142 0.0347 0.1012
Loa Loa (eye worm) hypothetical protein 0.0159 0.0392 0.375
Loa Loa (eye worm) hypothetical protein 0.0059 0.0117 0.1121
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0087 0.0832
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0026 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0252 0.0652 0.0651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0212 0.1763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0049 0.0087 0.1308
Brugia malayi CXXC zinc finger family protein 0.0079 0.0172 0.164
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0041 0.0331
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0063 0.0061
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0033 0.0094
Loa Loa (eye worm) hypothetical protein 0.0292 0.0763 0.7295
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0025 0.0021 0.002
Brugia malayi glutaminase DH11.1 0.0229 0.0588 0.5627
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0063 0.0128 0.5
Leishmania major acetyl-CoA synthetase, putative 0.0025 0.0021 0.0055
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.0147 0.0145
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0021 0.0206
Entamoeba histolytica hypothetical protein 0.0049 0.0087 0.1308
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0049 0.0087 0.6293
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0033 0.0094
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0021 0.0335
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0311
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0087 0.1333
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.0147 0.1405
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0087 0.1308
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0025 0.0021 0.033
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0041 0.0331
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0025 0.0021 0.0335
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0252 0.0652 0.0651
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0033 0.0094
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.0206
Echinococcus multilocularis serine protein kinase ATM 0.0142 0.0347 0.0345
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0026 0.007
Brugia malayi Trypsin-like protease protein 5 0.0029 0.0033 0.0311
Brugia malayi Calcitonin receptor-like protein seb-1 0.0222 0.0568 0.5427
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.0147 0.0145
Loa Loa (eye worm) transcription factor SMAD2 0.0206 0.0525 0.502
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0021 0.0206
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0049 0.0087 0.0253
Trichomonas vaginalis set domain proteins, putative 0.0448 0.1196 1
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0002 0.0018
Brugia malayi GH02984p 0.0292 0.0763 0.7295
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0029 0.0083
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0033 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0029 0.0275
Mycobacterium ulcerans hypothetical protein 0.0085 0.0188 0.3174
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0049 0.0087 0.1308
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0049 0.0087 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0029 0.0275
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0029 0.0275
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0063 0.0061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0029 0.0027
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0029 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0311
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0085 0.0188 0.6977
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0063 0.0183
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0021 0.0206
Trypanosoma cruzi target of rapamycin kinase 3 0.0252 0.0652 0.1877
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0087 0.3189
Echinococcus multilocularis zinc finger protein 0.0021 0.001 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0085 0.0188 0.3174
Onchocerca volvulus 0.0029 0.0033 0.0272
Brugia malayi hypothetical protein 0.0023 0.0017 0.0158
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0269 0.4549
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0002 0.0001
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0049 0.0087 0.0253
Echinococcus granulosus histone lysine methyltransferase setb 0.0072 0.0153 0.0151
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0029 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0029 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0087 0.0713
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0049 0.0087 0.0253
Brugia malayi Latrophilin receptor protein 2 0.007 0.0147 0.1405
Schistosoma mansoni aldehyde dehydrogenase 0.0114 0.0269 0.0783
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0252 0.0652 0.6238
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0029 0.0275
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0029 0.0275
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0029 0.0083
Brugia malayi latrophilin 2 splice variant baaae 0.0152 0.0373 0.3565
Schistosoma mansoni hypothetical protein 0.007 0.0147 0.0428
Schistosoma mansoni mixed-lineage leukemia protein mll 0.017 0.0423 0.1234
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0239 0.0616 0.5889
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0049 0.0087 0.1308
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0049 0.0087 0.1308
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0049 0.0087 0.0713
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0029 0.0033 0.0311
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.011 0.0257 0.0256
Loa Loa (eye worm) hypothetical protein 0.0063 0.0128 0.1228
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0041 0.0331
Loa Loa (eye worm) glutaminase 2 0.0229 0.0588 0.5627
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0252 0.0652 0.1807
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0002 0.0001
Echinococcus multilocularis neuropeptide s receptor 0.0431 0.1148 0.1146
Brugia malayi AMP-binding enzyme family protein 0.0085 0.0188 0.1798
Brugia malayi Bromodomain containing protein 0.0068 0.014 0.1336
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0087 0.0832
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0049 0.0087 0.0246
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0252 0.0652 0.1807
Schistosoma mansoni hypothetical protein 0.0027 0.0026 0.0075
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0049 0.0087 0.1308
Trypanosoma cruzi hypothetical protein, conserved 0.1267 0.3467 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0249
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0252 0.0652 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0252 0.0652 0.6238
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0114 0.0269 0.0267
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0049 0.0087 0.1308
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0049 0.0087 0.0832
Loa Loa (eye worm) hypothetical protein 0.004 0.0064 0.0614
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0142 0.0347 0.0996
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0002 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0085 0.0188 0.3174
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.0388 0.323
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0049 0.0087 0.6293
Schistosoma mansoni hypothetical protein 0.007 0.0147 0.0428
Loa Loa (eye worm) hypothetical protein 0.0063 0.0128 0.1228
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0033 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0002 0.0001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0029 0.024
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0252 0.0652 0.1903
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0017 0.0254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0063 0.0183
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0049 0.0087 0.0832
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0029 0.0083
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0032 0.0042 0.004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.0147 0.0145
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.0063 0.0604
Loa Loa (eye worm) hypothetical protein 0.0049 0.0087 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0002 0.0001
Entamoeba histolytica hypothetical protein 0.0049 0.0087 0.1308
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0252 0.0652 0.1807
Leishmania major hypothetical protein, unknown function 0.0049 0.0087 0.0236
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0049 0.0087 0.0713
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0087 0.1333
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0072 0.0153 0.0151
Echinococcus granulosus glycoprotein Antigen 5 0.0029 0.0033 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0087 0.6293
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0025 0.0021 0.002
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0252 0.0652 1
Schistosoma mansoni glutaminase 0.0229 0.0588 0.1716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0029 0.0275
Loa Loa (eye worm) hypothetical protein 0.0063 0.0128 0.1228
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0411 0.3426
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0002 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0252 0.0652 0.1903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Schistosoma mansoni hypothetical protein 0.0319 0.0839 0.2447
Mycobacterium ulcerans glutaminase 0.0229 0.0588 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0188 0.1798
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0142 0.0347 0.1012
Loa Loa (eye worm) hypothetical protein 0.0348 0.0918 0.878
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0049 0.0087 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0029 0.0275
Trichomonas vaginalis maltase-glucoamylase, putative 0.0032 0.0041 0.0331
Echinococcus granulosus lysosomal alpha glucosidase 0.0145 0.0354 0.0352
Onchocerca volvulus 0.0029 0.0033 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0347 0.2891
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0025 0.0021 0.0057
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0087 0.0085
Schistosoma mansoni hypothetical protein 0.007 0.0147 0.0428
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0394 0.1046 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0029 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0347 0.2891
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0049 0.0087 0.0832
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0269 0.4549
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0012 0.0011
Brugia malayi MH2 domain containing protein 0.0206 0.0525 0.502
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0087 0.0832
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0029 0.0027
Brugia malayi Glycosyl hydrolases family 31 protein 0.0032 0.0041 0.0396
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0017 0.0226
Schistosoma mansoni alpha-glucosidase 0.0125 0.0298 0.0869
Leishmania major phosphatidylinositol kinase, putative 0.0049 0.0087 0.0236
Schistosoma mansoni hypothetical protein 0.0736 0.1995 0.5821
Brugia malayi Trypsin family protein 0.0029 0.0033 0.0311
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0049 0.0087 0.0085
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0049 0.0087 0.0246
Onchocerca volvulus 0.0032 0.0042 0.0348
Brugia malayi nuclear receptor NHR-88 0.0028 0.0029 0.0275
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0049 0.0087 0.1308
Entamoeba histolytica hypothetical protein 0.0035 0.0048 0.071
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0049 0.0087 0.0085
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0021 0.0335
Entamoeba histolytica acyl-coA synthetase, putative 0.0085 0.0188 0.2862
Loa Loa (eye worm) CXXC zinc finger family protein 0.0079 0.0172 0.164
Onchocerca volvulus 0.0025 0.0021 0.018
Mycobacterium ulcerans hypothetical protein 0.0029 0.0033 0.0523
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0021 0.0335
Onchocerca volvulus 0.0084 0.0185 0.1543
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0087 0.0832
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0029 0.0275
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0036 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.0616 0.5141
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0145 0.0354 0.3384
Onchocerca volvulus 0.0448 0.1196 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0025 0.0021 0.0736
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0049 0.0087 0.1308
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0049 0.0087 0.0713
Loa Loa (eye worm) hypothetical protein 0.0032 0.0042 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0002 0.0001
Onchocerca volvulus 0.0029 0.0033 0.0272
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0113 0.0111
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0041 0.0608
Loa Loa (eye worm) hypothetical protein 0.0152 0.0373 0.3565
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.0002 0.0004
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0033 0.0094
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0033 0.0094
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0252 0.0652 0.0651
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0275
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0021 0.0335
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.0616 0.5141
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0049 0.0087 0.0246
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0063 0.0128 0.2158
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0087 0.0832
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0033 0.0094
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0032 0.0041 0.0635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0275
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0018
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0029 0.0083
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0049 0.0087 0.0713
Loa Loa (eye worm) PHD-finger family protein 0.0017 0 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Schistosoma mansoni DNA polymerase eta 0.0018 0.0002 0.0004
Onchocerca volvulus 0.0145 0.0354 0.2964
Echinococcus granulosus enteropeptidase 0.0029 0.0033 0.0031
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0017 0.0015
Schistosoma mansoni hypothetical protein 0.0319 0.0839 0.2447
Echinococcus granulosus solute carrier family 5 0.0032 0.0042 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0029 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0021 0.0335
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0001
Onchocerca volvulus 0.0085 0.0188 0.1572
Plasmodium vivax SET domain protein, putative 0.0058 0.0113 0.8641
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0113 0.0329
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0029 0.0027
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0087 0.1333
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0049 0.0087 0.0253
Onchocerca volvulus 0.0079 0.0172 0.1434
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0063 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0029 0.0275
Schistosoma mansoni hypothetical protein 0.0029 0.0033 0.0094
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0049 0.0087 0.0246
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0311
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0029 0.0033 0.0094
Onchocerca volvulus 0.0058 0.0113 0.0947
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0029 0.0027
Echinococcus granulosus neuropeptide receptor A26 0.0431 0.1148 0.1146
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0085 0.0188 0.1798
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0275
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0049 0.0087 0.0713
Echinococcus granulosus serine protein kinase ATM 0.0142 0.0347 0.0345
Schistosoma mansoni coup transcription factor 0.0028 0.0029 0.0083
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0348 0.0918 0.2679
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0025 0.0021 0.0736
Onchocerca volvulus 0.0049 0.0087 0.0727
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0252 0.0652 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0252 0.0652 0.1877
Trichomonas vaginalis helicase, putative 0.0018 0.0002 0.0001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0029 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0188 0.6977
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0055 0.0104 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0153 0.0445
Echinococcus multilocularis lysosomal alpha glucosidase 0.0145 0.0354 0.0352
Echinococcus multilocularis geminin 0.0319 0.0839 0.0837
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0026 0.0024
Onchocerca volvulus 0.0025 0.0021 0.018
Echinococcus granulosus tissue type plasminogen activator 0.0027 0.0026 0.0024
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0029 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0029 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0159 0.0392 0.6001
Toxoplasma gondii FATC domain-containing protein 0.0142 0.0347 0.5321
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0029 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0025 0.0021 0.0302
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0041 0.0331
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0049 0.0087 0.6293
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0021 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0049 0.0087 0.6293
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0029 0.0282
Mycobacterium ulcerans acyl-CoA synthetase 0.0085 0.0188 0.3174
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.0388 0.323
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.0002 0.0004
Loa Loa (eye worm) trypsin family protein 0.0029 0.0033 0.0311
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0025 0.0021 0.0335
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0048 0.0139
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.0388 0.323
Plasmodium vivax acyl-CoA synthetase, putative 0.0063 0.0128 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0017 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0033 0.0094
Brugia malayi Protein kinase domain containing protein 0.0027 0.0026 0.0249
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0049 0.0087 0.0713
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0021 0.0335
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0049 0.0087 0.1308
Leishmania major hypothetical protein, conserved 0.1315 0.3601 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0049 0.0087 0.1308
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0032 0.0042 0.004
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0033 0.0094
Onchocerca volvulus 0.0028 0.0029 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Schistosoma mansoni alpha-glucosidase 0.0125 0.0298 0.0869
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0049 0.0087 0.0085
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0029 0.0027
Toxoplasma gondii target of rapamycin (TOR), putative 0.0252 0.0652 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0252 0.0652 0.1807
Loa Loa (eye worm) hypothetical protein 0.0142 0.0347 0.3319
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0029 0.0083
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0142 0.0347 0.3319
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.0388 0.323
Loa Loa (eye worm) hypothetical protein 0.0145 0.0354 0.339
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0049 0.0087 0.0246
Schistosoma mansoni cpg binding protein 0.0085 0.0189 0.0549
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0252 0.0652 1
Plasmodium vivax hypothetical protein 0.0049 0.0087 0.6293
Giardia lamblia GTOR 0.0252 0.0652 1
Brugia malayi PHD-finger family protein 0.0025 0.0023 0.0219
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0041 0.0331
Leishmania major phosphatidylinositol 3-kinase, putative 0.0049 0.0087 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Loa Loa (eye worm) hypothetical protein 0.0063 0.0128 0.1228
Echinococcus granulosus zinc finger protein 0.0021 0.001 0.0009
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0049 0.0087 0.0246
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0033 0.0094
Brugia malayi FAT domain containing protein 0.011 0.0257 0.2462
Schistosoma mansoni inositol transporter 0.0032 0.0042 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0087 0.0713
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0348 0.0918 0.2679
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0094 0.0212 0.0608
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0002 0.0018
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0025 0.0021 0.0206
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0252 0.0652 0.1807
Loa Loa (eye worm) hypothetical protein 0.0063 0.0128 0.1228
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0021 0.0736
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.0388 0.323
Schistosoma mansoni cpg binding protein 0.0079 0.0172 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0392 0.3268
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0252 0.0652 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0145 0.0354 0.0352
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0049 0.0087 0.0246
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0087 0.0832
Toxoplasma gondii propionate-CoA ligase 0.0025 0.0021 0.033
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0029 0.0027
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0142 0.0347 0.0996
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0017 0.0042
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0033 0.0094
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0041 0.0331
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0275
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0029 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0411 0.3426
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0063 0.0183
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0021 0.0206
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0021 0.0206
Entamoeba histolytica hypothetical protein 0.0049 0.0087 0.1308
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.0616 0.5141
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0049 0.0087 0.0253
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0452
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0087 0.0832
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0029 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0021 0.0335
Echinococcus multilocularis tissue type plasminogen activator 0.0027 0.0026 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0021 0.0335
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.006 0.0119 0.4383
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.006 0.0119 0.4383
Schistosoma mansoni bromodomain containing protein 0.0058 0.0112 0.0327
Schistosoma mansoni cpg binding protein 0.0085 0.0189 0.0549
Onchocerca volvulus 0.0029 0.0033 0.0272
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0087 0.0832
Brugia malayi AMP-binding enzyme family protein 0.0085 0.0188 0.1798
Echinococcus multilocularis GPCR, family 2 0.007 0.0147 0.0145
Echinococcus granulosus sodium:glucose cotransporter 0.0032 0.0042 0.004
Entamoeba histolytica hypothetical protein 0.0035 0.0048 0.071
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.0252 0.0652 0.6238
Brugia malayi ecdysteroid receptor 0.0028 0.0029 0.0275
Leishmania major acetyl-CoA synthetase, putative 0.0025 0.0021 0.0055
Echinococcus multilocularis cpg binding protein 0.0085 0.0189 0.0187
Brugia malayi Pre-SET motif family protein 0.0058 0.0113 0.1083
Echinococcus multilocularis high affinity choline transporter 1 0.0292 0.0763 0.0761
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0029 0.0275
Loa Loa (eye worm) hypothetical protein 0.011 0.0257 0.2462
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.0063 0.0604
Echinococcus multilocularis Mastin 0.0029 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0347 0.2891
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0142 0.0347 0.5307
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0142 0.0347 0.5307
Onchocerca volvulus 0.0319 0.0838 0.7004
Schistosoma mansoni hypothetical protein 0.0029 0.0033 0.0094
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0021 0.0206
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0036 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0085 0.0188 0.1798
Schistosoma mansoni high-affinity choline transporter 0.0292 0.0763 0.2226
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0085 0.0188 0.3174
Echinococcus granulosus high affinity choline transporter 1 0.0292 0.0763 0.0761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0029 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0029 0.0275
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0049 0.0087 0.6293
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0049 0.0087 0.0713
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0252 0.0652 0.1877
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0252 0.0652 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.011 0.0257 0.0256
Loa Loa (eye worm) hypothetical protein 0.0222 0.0568 0.5427
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0029 0.0027
Trichomonas vaginalis antibiotic synthetase, putative 0.0025 0.0021 0.0164
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0311
Brugia malayi Kringle domain containing protein 0.0027 0.0026 0.0249
Echinococcus granulosus dnaJ subfamily B 0.0736 0.1995 0.1993
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0029 0.0083
Trichomonas vaginalis glutaminase, putative 0.0229 0.0588 0.4911
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0085 0.0188 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0063 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0347 0.2891
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0239 0.0616 0.5889
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0017 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0222 0.0568 0.5427
Echinococcus multilocularis Zinc finger, PHD finger 0.0049 0.0087 0.0085
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0012 0.0011
Echinococcus granulosus transmembrane protease serine 3 0.0029 0.0033 0.0031
Echinococcus granulosus cpg binding protein 0.0085 0.0189 0.0187
Schistosoma mansoni hypothetical protein 0.007 0.0147 0.0428
Schistosoma mansoni alpha glucosidase 0.0032 0.0041 0.012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0055 0.0104 0.0102
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0222 0.0568 0.5427
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.0388 0.323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Echinococcus granulosus geminin 0.0319 0.0839 0.0837
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0017 0.0015
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.0147 0.1405
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0029 0.0033 0.0031
Onchocerca volvulus 0.0027 0.0026 0.0218
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0087 0.0832
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0012 0.0375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0212 0.1763
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0029 0.0027
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0029 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0021 0.0335
Entamoeba histolytica hypothetical protein 0.0035 0.0048 0.071
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.0616 0.5141
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0025 0.0021 0.0057
Plasmodium falciparum cysteine repeat modular protein 1 0.0027 0.0026 0.0851
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0054 0.0103 0.0101
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0025 0.0021 0.0335
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0087 0.3931
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0029 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0252 0.0652 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.006 0.0119 0.4383
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0021 0.0736
Echinococcus granulosus sodium:myo inositol cotransporter 0.0032 0.0042 0.004
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0029 0.024
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0033 0.0094
Schistosoma mansoni hypothetical protein 0.0152 0.0373 0.1087
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0025 0.0021 0.0335
Trichomonas vaginalis sucrase-isomaltase, putative 0.0032 0.0041 0.0331
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0087 0.0085
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0048 0.0046
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0032 0.0042 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0001
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0026 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Brugia malayi steroid hormone receptor 0.0028 0.0029 0.0275
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0049 0.0087 0.0085
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0252 0.0652 0.6238
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0049 0.0087 0.0236
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0049 0.0087 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.0616 0.5141
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0021 0.0206
Entamoeba histolytica hypothetical protein 0.0049 0.0087 0.1308
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0085 0.0188 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0049 0.0087 0.0832
Plasmodium vivax acetyl-CoA synthetase, putative 0.0025 0.0021 0.0441
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0041 0.0608
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0012 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0041 0.0114
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0025 0.0021 0.0302
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0049 0.0087 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0002 0.0001
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0029 0.0027
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0025 0.0021 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0049 0.0087 0.1308
Brugia malayi Glycosyl hydrolases family 31 protein 0.0145 0.0354 0.3384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Echinococcus multilocularis microtubule associated protein 2 0.1252 0.3426 0.3425
Leishmania major hypothetical protein, conserved 0.0023 0.0017 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0347 0.2891
Entamoeba histolytica acyl-CoA synthetase, putative 0.0085 0.0188 0.2862
Loa Loa (eye worm) hypothetical protein 0.0032 0.0042 0.0399
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0025 0.0021 0.0736
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0021 0.0736
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0029 0.0275
Leishmania major alpha glucosidase II subunit, putative 0.0032 0.0041 0.011
Onchocerca volvulus 0.0029 0.0033 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Loa Loa (eye worm) hypothetical protein 0.0094 0.0212 0.2031
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0025 0.0021 0.0302
Leishmania major 4-coumarate:coa ligase-like protein 0.0085 0.0188 0.0517
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0252 0.0652 0.0651
Leishmania major 4-coumarate:coa ligase-like protein 0.0085 0.0188 0.0517
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0027 0.0026 0.0851
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0087 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.0616 0.5141
Entamoeba histolytica hypothetical protein 0.0035 0.0048 0.071
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0085 0.0188 0.3174
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0033 0.0094
Loa Loa (eye worm) glutaminase 0.0229 0.0588 0.5627
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0002 0.0001
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0032 0.0042 0.0639
Echinococcus multilocularis glycoprotein Antigen 5 0.0029 0.0033 0.0031
Entamoeba histolytica hypothetical protein 0.0142 0.0347 0.5307
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0025 0.0021 0.033
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0049 0.0087 0.0713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0029 0.0275
Onchocerca volvulus 0.0025 0.0021 0.018
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0049 0.0087 0.0246
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0041 0.0114
Leishmania major phosphatidylinositol kinase related protein, putative 0.0049 0.0087 0.0236
Giardia lamblia Hypothetical protein 0.0049 0.0087 0.1308
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0063 0.0128 0.4744
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0033 0.0094
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0049 0.0087 0.0713
Leishmania major phosphatidylinositol 4-kinase, putative 0.0049 0.0087 0.0236
Schistosoma mansoni sodium/solute symporter 0.0032 0.0042 0.0121
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0114 0.0269 0.0741
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0087 0.0832
Echinococcus granulosus GPCR family 2 0.007 0.0147 0.0145
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0114 0.0269 0.0267
Trichomonas vaginalis antibiotic synthetase, putative 0.0025 0.0021 0.0164
Entamoeba histolytica protein kinase rad3, putative 0.0142 0.0347 0.5307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0652 0.5446
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0029 0.0275
Schistosoma mansoni hypothetical protein 0.0035 0.0048 0.0139
Leishmania major hypothetical protein, conserved 0.0027 0.0026 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0087 0.0713
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0025 0.0021 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0347 0.2891
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0049 0.0087 0.6293
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.221 0.6085 0.6084
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0049 0.0087 0.6293
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0269 0.4549
Echinococcus multilocularis transmembrane protease serine 3 0.0029 0.0033 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0002 0.0001
Brugia malayi Bromodomain containing protein 0.0032 0.0042 0.0398
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.0153 0.0445
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0025 0.0021 0.0335
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0029 0.0275
Loa Loa (eye worm) hypothetical protein 0.0348 0.0918 0.878
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0049 0.0087 0.0085
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0142 0.0347 0.3319
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0275
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0049 0.0087 0.1308
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0029 0.0083
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0252 0.0652 0.1877
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0049 0.0087 0.0713
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0114 0.0269 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0029 0.0275
Echinococcus multilocularis neuropeptide receptor A26 0.0431 0.1148 0.1146
Brugia malayi hypothetical protein 0.0145 0.0354 0.339
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0048 0.0046
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0087 0.0085
Entamoeba histolytica acyl-CoA synthetase, putative 0.0085 0.0188 0.2862
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0025 0.0021 0.0335
Brugia malayi Pre-SET motif family protein 0.0394 0.1046 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0153 0.1463
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0252 0.0652 0.1877
Echinococcus multilocularis neutral alpha glucosidase AB 0.0032 0.0041 0.004
Toxoplasma gondii kringle domain-containing protein 0.0027 0.0026 0.04
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0032 0.0041 0.0396
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0049 0.0087 0.0713
Loa Loa (eye worm) TK/ROR protein kinase 0.0027 0.0026 0.0249
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0087 0.0832
Echinococcus multilocularis dnaJ subfamily B 0.0736 0.1995 0.1993
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0025 0.0021 0.0736
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0029 0.0027
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0159 0.0392 0.6012
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0049 0.0087 0.0246
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.0388 0.323
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0142 0.0347 0.0345
Schistosoma mansoni aldehyde dehydrogenase 0.0114 0.0269 0.0783
Giardia lamblia Phosphatidylinositol 4-kinase 0.0049 0.0087 0.1308

Activities

Activity type Activity value Assay description Source Reference
ED200 (functional) = 50 uM The Anti-coagulant activity was tested by measuring activated partial thromboplastin time (aPTT) ChEMBL. 9836616
ED200 (functional) = 50 uM The Anti-coagulant activity was tested by measuring activated partial thromboplastin time (aPTT) ChEMBL. 9836616
ED200 (functional) > 500 uM The Anti-coagulant activity was tested by measuring thrombin clotting time (TT) ChEMBL. 9836616
ED200 (functional) > 500 uM The Anti-coagulant activity was tested by measuring thrombin clotting time (TT) ChEMBL. 9836616
Ki (binding) = 1 uM The inhibition constant against human Coagulation factor X ChEMBL. 9836616
Ki (binding) = 1 uM The inhibition constant against human Coagulation factor X ChEMBL. 9836616
Ki (binding) = 10 uM The inhibition constant of the compound against human trypsin ChEMBL. 9836616
Ki (binding) = 10 uM The inhibition constant against human plasmin ChEMBL. 9836616
Ki (binding) = 10 uM The inhibition constant of the compound against human trypsin ChEMBL. 9836616
Ki (binding) = 10 uM The inhibition constant against human plasmin ChEMBL. 9836616
Ki (binding) > 100 uM The inhibition constant against human thrombin ChEMBL. 9836616
Ki (binding) > 100 uM The inhibition constant against human thrombin ChEMBL. 9836616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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