Detailed information for compound 276698

Basic information

Technical information
  • TDR Targets ID: 276698
  • Name: 4-[2-[2-[(2R)-2-(hydroxymethyl)pyrrolidin-1-y l]ethyl]-1-benzofuran-5-yl]benzonitrile
  • MW: 346.422 | Formula: C22H22N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1CCCN1CCc1cc2c(o1)ccc(c2)c1ccc(cc1)C#N
  • InChi: 1S/C22H22N2O2/c23-14-16-3-5-17(6-4-16)18-7-8-22-19(12-18)13-21(26-22)9-11-24-10-1-2-20(24)15-25/h3-8,12-13,20,25H,1-2,9-11,15H2/t20-/m1/s1
  • InChiKey: JFCPJZQAWZEYPU-HXUWFJFHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-[2-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]ethyl]benzofuran-5-yl]benzonitrile
  • 4-[2-[2-[(2R)-2-(hydroxymethyl)-1-pyrrolidinyl]ethyl]-5-benzofuranyl]benzonitrile
  • 4-[2-[2-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]ethyl]-1-benzofuran-5-yl]benzenecarbonitrile
  • 4-[2-[2-[(2R)-2-methylolpyrrolidino]ethyl]benzofuran-5-yl]benzonitrile
  • 4-[2-[2-[(2R)-2-methylolpyrrolidin-1-yl]ethyl]benzofuran-5-yl]benzonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H3 Starlite/ChEMBL References
Rattus norvegicus Histamine H3 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Histamine H3 receptor   445 aa 384 aa 22.4 %
Echinococcus granulosus biogenic amine 5HT receptor Histamine H3 receptor   445 aa 405 aa 25.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.2243 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0854 0.0995
Plasmodium vivax SET domain protein, putative 0.0129 0.0941 0.2719
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Echinococcus multilocularis rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0129 0.027
Echinococcus granulosus single minded 2 0.0042 0.0209 0.0178
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0204 0.0879
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Schistosoma mansoni neuropeptide receptor 0.0941 0.7762 0.7755
Schistosoma mansoni neuropeptide F-like receptor 0.0941 0.7762 0.7755
Brugia malayi MH2 domain containing protein 0.0121 0.0873 0.0873
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0418 0.3369 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.2562 0.7577
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0124 0.0902 0.0872
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0149 0.1111 0.1082
Echinococcus granulosus neuropeptide s receptor 0.0941 0.7762 0.7755
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.033 0.0874
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0169 0.0183
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0941 0.7762 0.7762
Schistosoma mansoni amine GPCR 0.0941 0.7762 0.7755
Echinococcus granulosus g protein coupled receptor 0.0941 0.7762 0.7755
Brugia malayi hypothetical protein 0.0941 0.7762 0.7762
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0936 0.7723 0.7716
Schistosoma mansoni hypothetical protein 0.0149 0.1111 0.108
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0129 0.0941 0.091
Schistosoma mansoni inositol monophosphatase 0.0037 0.0169 0.0135
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0418 0.3369 0.3348
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0854 0.2447
Echinococcus granulosus neuroglian 0.0027 0.0089 0.0057
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0129 0.0283
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0089 0.0057
Echinococcus multilocularis serotonin receptor 0.0941 0.7762 0.7755
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Entamoeba histolytica hypothetical protein 0.0023 0.0057 0.0083
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0129 0.027
Echinococcus multilocularis neuropeptide s receptor 0.0941 0.7762 0.7755
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0384 0.0438
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0089 0.0055
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.033 1
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0204 0.0495
Echinococcus multilocularis lachesin 0.0027 0.0089 0.0057
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0137 0.0899
Brugia malayi jmjC domain containing protein 0.006 0.0365 0.0365
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.014 0.0108
Brugia malayi Cytochrome P450 family protein 0.0022 0.0049 0.0049
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0855 0.0823
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0204 0.0224
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0118 0.0854 0.2447
Schistosoma mansoni hypothetical protein 0.0072 0.0464 0.0431
Echinococcus multilocularis rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0072 0.0464 0.0433
Loa Loa (eye worm) hypoxia-induced factor 1 0.0174 0.132 0.1292
Brugia malayi Serotonin receptor 0.0941 0.7762 0.7762
Brugia malayi Dopamine receptor protein 2 0.0941 0.7762 0.7762
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0941 0.7762 0.7755
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0136 0.029
Echinococcus granulosus rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0041 0.0008
Schistosoma mansoni hypothetical protein 0.0033 0.014 0.0106
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0855 0.2449
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0166 0.0381
Brugia malayi phosphofructokinase 0.0118 0.0855 0.0855
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0041 0.0041
Brugia malayi G protein-coupled receptor F59B2.13 0.0941 0.7762 0.7762
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0136 0.0104
Schistosoma mansoni septate junction protein 0.0027 0.0089 0.0055
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0049 0.0017
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0418 0.3369 1
Onchocerca volvulus 0.0941 0.7762 0.9194
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.033 0.0874
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0103 0.0193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0941 0.7762 0.7755
Echinococcus multilocularis neuroglian 0.0027 0.0089 0.0057
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni biogenic amine (5HT) receptor 0.0941 0.7762 0.7755
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.033 0.0874
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0041 0.0041
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.028 0.2212 0.2187
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.026 0.0675
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0169 0.0183
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.014 0.0108
Echinococcus multilocularis rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Schistosoma mansoni ran 0.0021 0.0039 0.0004
Trichomonas vaginalis set domain proteins, putative 0.1021 0.8439 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0066 0.008
Plasmodium vivax hypothetical protein, conserved 0.0023 0.005 0.0048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0166 0.0662
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0041 0.0008
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0941 0.7762 0.7755
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0129 0.0135
Brugia malayi Peroxidasin 0.0027 0.0089 0.0089
Echinococcus granulosus dna polymerase kappa 0.0041 0.0204 0.0172
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0041 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2243 0.2645
Loa Loa (eye worm) melatonin receptor type 1A 0.0941 0.7762 0.7755
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.014 0.0108
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni lamin 0.006 0.0368 0.0335
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0096 0.0663 0.077
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Brugia malayi 6-phosphofructokinase 0.0118 0.0855 0.0855
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0941 0.7762 0.7755
Brugia malayi G protein-coupled receptor 0.0941 0.7762 0.7762
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0322 0.2562 0.7577
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0136 0.029
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0032 0.0032
Echinococcus granulosus snurportin 1 0.0309 0.2453 0.2429
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0941 0.7762 0.7755
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.033 0.0874
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0204 0.0204
Echinococcus granulosus neuropeptide Y receptor 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0028 0.0096 0.0064
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0041 0.0008
Onchocerca volvulus 0.1021 0.844 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0097 0.0175
Schistosoma mansoni amine GPCR 0.0941 0.7762 0.7755
Schistosoma mansoni amine GPCR 0.0941 0.7762 0.7755
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0109 0.0777 0.0747
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2243 0.2645
Echinococcus granulosus orexin receptor type 2 0.0941 0.7762 0.7755
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0089 0.0057
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0941 0.7762 0.9194
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0109 0.0777 0.2216
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0204 0.0495
Echinococcus multilocularis RUN 0.0021 0.0035 0.0002
Toxoplasma gondii ABC1 family protein 0.0036 0.0166 0.0381
Echinococcus multilocularis adenylate cyclase type IX 0.0128 0.0932 0.0902
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni septate junction protein 0.0027 0.0089 0.0055
Schistosoma mansoni biogenic amine receptor 0.0941 0.7762 0.7755
Brugia malayi hypothetical protein 0.0941 0.7762 0.7762
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0132 0.01
Entamoeba histolytica hypothetical protein 0.0149 0.1111 0.4863
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0736 0.6039 0.6027
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0166 0.0662
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0941 0.7762 0.7755
Brugia malayi hypothetical protein 0.0133 0.0974 0.0974
Loa Loa (eye worm) inositol-1 0.0037 0.0169 0.0137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0002
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0008
Echinococcus granulosus neuropeptide receptor 0.0941 0.7762 0.7755
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.033 0.0374
Onchocerca volvulus Neuropeptide F receptor homolog 0.0941 0.7762 0.9194
Loa Loa (eye worm) intermediate filament protein 0.006 0.0368 0.0337
Echinococcus granulosus neuropeptide receptor 0.0941 0.7762 0.7755
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.2212 0.2185
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0056 0.033 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0041 0.0041
Giardia lamblia DINP protein human, muc B family 0.0041 0.0204 0.0749
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0041 0.0006
Schistosoma mansoni coup transcription factor 0.0021 0.0041 0.0006
Echinococcus multilocularis g-protein coupled receptor 0.0941 0.7762 0.7755
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0041 0.0041
Brugia malayi beta-lactamase 0.0036 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Loa Loa (eye worm) RNA binding protein 0.0064 0.0397 0.0366
Echinococcus granulosus rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0136 0.0104
Trypanosoma brucei unspecified product 0.0028 0.0097 0.0175
Schistosoma mansoni intermediate filament proteins 0.006 0.0368 0.0335
Loa Loa (eye worm) beta-lactamase 0.0036 0.0166 0.0134
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0204 0.017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0057
Mycobacterium tuberculosis Conserved protein 0.0036 0.0166 0.0662
Onchocerca volvulus 0.0941 0.7762 0.9194
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0027 0.0089 0.0055
Brugia malayi follicle stimulating hormone receptor 0.1206 0.9993 0.9993
Onchocerca volvulus 0.0091 0.0623 0.07
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0378 0.0347
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0109 0.0777 0.2216
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0855 0.2449
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Echinococcus granulosus adenylate cyclase type IX 0.0128 0.0932 0.0902
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0384 0.0438
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0941 0.7762 0.7755
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0365 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Toxoplasma gondii hypothetical protein 0.0062 0.0384 0.1036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0041 0.0008
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0035 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0041 0.0008
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.033 0.033
Giardia lamblia Kinase, CMGC MAPK 0.0109 0.0777 0.3349
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.033 0.0296
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0855 0.0825
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0134
Mycobacterium ulcerans hypothetical protein 0.0169 0.1283 1
Echinococcus granulosus lachesin 0.0027 0.0089 0.0057
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0209 0.1299
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0112 0.0803 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0041 0.0041
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0079 0.052 0.0489
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0941 0.7762 0.7755
Schistosoma mansoni nephrin 0.0028 0.0094 0.006
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0041 0.0006
Echinococcus granulosus neuropeptides capa receptor 0.0941 0.7762 0.7755
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0041 0.0041
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0136 0.029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0089 0.0089
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.028 0.2212 0.2212
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0041 0.0007
Giardia lamblia Hypothetical protein 0.0056 0.033 0.132
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0008
Echinococcus multilocularis tyrosine protein kinase otk 0.0027 0.0089 0.0057
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0941 0.7762 0.7762
Echinococcus granulosus fmrfamide receptor 0.0941 0.7762 0.7755
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0777 0.0904
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0035 0.0002
Echinococcus multilocularis snurportin 1 0.0309 0.2453 0.2429
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0941 0.091
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0397 0.0364
Brugia malayi 6-phosphofructokinase 0.0118 0.0855 0.0855
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0397 0.0366
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.033 0.0374
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0056 0.033 0.0299
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0365 0.0334
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0418 0.3369 0.3348
Loa Loa (eye worm) hypothetical protein 0.0056 0.033 0.0299
Echinococcus granulosus geminin 0.0367 0.2941 0.2918
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0027 0.0089 0.0057
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0204 0.0172
Loa Loa (eye worm) hypothetical protein 0.006 0.0368 0.0337
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0397 0.0364
Brugia malayi Cytochrome P450 family protein 0.0062 0.0378 0.0378
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0166 0.0662
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0136 0.0303
Echinococcus multilocularis neuropeptide Y receptor 0.0941 0.7762 0.7755
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0854 0.2447
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Loa Loa (eye worm) nuclear hormone receptor 0.0101 0.0708 0.0677
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0136 0.0104
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0056 0.033 0.0299
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0941 0.7762 0.7755
Schistosoma mansoni netrin receptor unc5 0.0031 0.012 0.0086
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0464 0.0464
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.1219 0.1188
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0112 0.0803 0.0773
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0204 0.0172
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0134
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0855 0.457
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0166 0.0132
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0166 0.0134
Brugia malayi larval opioid receptor 0.0941 0.7762 0.7762
Onchocerca volvulus 0.0941 0.7762 0.9194
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0365 0.0334
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.033 0.0374
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0345 0.2763 0.2739
Brugia malayi Cytochrome P450 family protein 0.0022 0.0049 0.0049
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1024 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0118 0.0854 0.0995
Schistosoma mansoni opsin-like receptor 0.0941 0.7762 0.7755
Echinococcus multilocularis allatostatin A receptor 0.0941 0.7762 0.7755
Loa Loa (eye worm) G-protein coupled receptor 0.0941 0.7762 0.7755
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0089 0.0089
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0204 0.0204
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0035 0.0002
Leishmania major DNA polymerase eta, putative 0.0041 0.0204 0.0495
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.033 0.0374
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0041 0.0008
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0941 0.7762 0.7755
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Brugia malayi nuclear hormone receptor 0.0021 0.0041 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0365 0.0332
Brugia malayi Steroid receptor seven-up type 2 0.0112 0.0803 0.0803
Echinococcus granulosus rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.033 0.0374
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0089 0.0089
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0169 0.059
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0035 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0941 0.7762 0.7755
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0418 0.3369 1
Schistosoma mansoni tyrosine kinase 0.0036 0.0161 0.0127
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.033 0.0374
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0049 0.003
Brugia malayi GnHR receptor homolog 0.0941 0.7762 0.7762
Brugia malayi Immunoglobulin I-set domain containing protein 0.0736 0.6039 0.6039
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0941 0.7762 0.7755
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0941 0.7762 0.7755
Brugia malayi steroid hormone receptor 0.0021 0.0041 0.0041
Leishmania major hypothetical protein, conserved 0.0056 0.033 0.0874
Echinococcus granulosus tar DNA binding protein 0.0064 0.0397 0.0366
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.033 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0534 0.0503
Loa Loa (eye worm) acetyltransferase 0.0162 0.1219 0.119
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0744 0.0714
Schistosoma mansoni neuroglian 0.0027 0.0089 0.0055
Trypanosoma brucei unspecified product 0.0041 0.0204 0.0495
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0941 0.7762 0.7755
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0941 0.7762 0.7755
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.1219 0.1219
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0136 0.0104
Brugia malayi TAR-binding protein 0.0064 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0166 0.0179
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0397 0.2822
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0941 0.7762 0.7755
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.033 0.0296
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0169 0.0137
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0226 0.085
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0397 0.2822
Echinococcus granulosus 7TM GPCR rhodopsin 0.0941 0.7762 0.7755
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0035 0.0002
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.033 0.0296
Leishmania major hypothetical protein, conserved 0.0056 0.033 0.0874
Echinococcus multilocularis g protein coupled receptor 0.0941 0.7762 0.7755
Schistosoma mansoni cell adhesion molecule 0.0027 0.0089 0.0055
Loa Loa (eye worm) hypothetical protein 0.0056 0.033 0.0299
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0854 0.0995
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0365 0.0334
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0941 0.7762 0.7755
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0066 0.008
Echinococcus multilocularis roundabout 2 0.0027 0.0089 0.0057
Echinococcus granulosus RUN 0.0021 0.0035 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0057 0.005
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.2243 1
Echinococcus granulosus microtubule associated protein 2 0.077 0.6327 0.6315
Echinococcus multilocularis lamin 0.006 0.0368 0.0337
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0226 0.6492
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0129 0.0408
Schistosoma mansoni cell adhesion molecule 0.0027 0.0089 0.0055
Schistosoma mansoni titin 0.0027 0.0089 0.0055
Schistosoma mansoni hypothetical protein 0.0367 0.2941 0.2916
Schistosoma mansoni hypothetical protein 0.0033 0.014 0.0106
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0103 0.0193
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0039 0.0007
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0941 0.7762 0.7755
Onchocerca volvulus 0.0053 0.0301 0.0318
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0041 0.0008
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1024 0.5531
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0397 0.0366
Schistosoma mansoni aryl hydrocarbon receptor 0.0056 0.0332 0.0298
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0109 0.0777 0.2216
Brugia malayi putative neuropeptide receptor 0.0941 0.7762 0.7762
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0056 0.033 0.132
Leishmania major DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Echinococcus multilocularis neuropeptide receptor 0.0941 0.7762 0.7755
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0041 0.0008
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0079 0.052 0.0489
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0079 0.052 0.052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0057
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0166 0.0134
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0166 0.0662
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0035 0.0002
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.005 0.0536
Onchocerca volvulus 0.006 0.0368 0.0397
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0129 0.3191
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0854 0.0995
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0118 0.0854 0.2447
Brugia malayi neuropeptide F receptor 0.0941 0.7762 0.7762
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0097 0.0175
Loa Loa (eye worm) cytochrome P450 0.0022 0.0049 0.0017
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.033 0.0886
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0041 0.0007
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0226 0.085
Schistosoma mansoni DNA polymerase eta 0.0041 0.0204 0.017
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0855 0.3433
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0041 0.0008
Onchocerca volvulus 0.0036 0.0166 0.0156
Loa Loa (eye worm) hypothetical protein 0.0043 0.0223 0.0191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0941 0.7762 0.7755
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.033 0.0874
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0007
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0089 0.0089
Echinococcus multilocularis sex peptide receptor 0.0941 0.7762 0.7755
Schistosoma mansoni hypothetical protein 0.0309 0.2453 0.2427
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0129 0.5
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0079 0.052 0.052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2243 0.2645
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0169 0.039
Brugia malayi Dopamine receptor protein 1 0.0941 0.7762 0.7762
Echinococcus granulosus neuropeptide FF receptor 2 0.0941 0.7762 0.7755
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0941 0.7762 0.7755
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0855 0.0997
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.026 0.029
Onchocerca volvulus 0.0696 0.5706 0.6747
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0204 0.017
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0204 0.0495
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Onchocerca volvulus 0.0941 0.7762 0.9194
Brugia malayi MAP kinase sur-1 0.0109 0.0777 0.0777
Entamoeba histolytica hypothetical protein 0.0149 0.1111 0.4863
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0066 0.008
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0105 0.0744 0.0714
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0049 0.003
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0854 0.0995
Onchocerca volvulus 0.0021 0.0041 0.0007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.2243 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Trichomonas vaginalis esterase, putative 0.0036 0.0166 0.0179
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0397 0.0366
Toxoplasma gondii hypothetical protein 0.0023 0.005 0.0034
Echinococcus multilocularis neuropeptide FF receptor 2 0.0941 0.7762 0.7755
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0941 0.7762 0.7755
Toxoplasma gondii GAF domain-containing protein 0.0023 0.005 0.0034
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0057 0.0055
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Echinococcus granulosus tm gpcr rhodopsin 0.0941 0.7762 0.7755
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1139 0.3303
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0169 0.0183
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0166 0.0134
Loa Loa (eye worm) hypothetical protein 0.0087 0.059 0.056
Brugia malayi neuropeptide F receptor 0.0941 0.7762 0.7762
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0057
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0204 0.0749
Leishmania major hypothetical protein, conserved 0.0024 0.0066 0.008
Echinococcus granulosus GPCR family 2 0.0033 0.014 0.0108
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.0777 0.2216
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.033 0.0374
Brugia malayi beta-lactamase family protein 0.0036 0.0166 0.0166
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.1139 0.3303
Echinococcus granulosus somatostatin receptor 0.0941 0.7762 0.7755
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0041 0.0007
Echinococcus granulosus twitchin 0.0029 0.0102 0.007
Echinococcus granulosus hemicentin 1 0.0027 0.0089 0.0057
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0057
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0169 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0941 0.091
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0855 0.3701
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0855 0.3701
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0323 0.0854
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0854 0.0995
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0166 0.0662
Schistosoma mansoni hypothetical protein 0.0033 0.014 0.0106
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0418 0.3369 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0066 0.008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0089 0.0089
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0777 0.0904
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0397 0.0366
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0855 0.0825
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0204 0.0495
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2243 0.2645
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0136 0.0136
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0035 0.0002
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0169 0.039
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0041 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1139 0.3303
Echinococcus granulosus hypothetical protein 0.0941 0.7762 0.7755
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.0777 0.2216
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0204 0.0172
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.033 0.0299
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2243 0.2645
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.033 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.014 0.0108
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0041 0.0006
Brugia malayi hypothetical protein 0.0941 0.7762 0.7762
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.014 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.2212 0.2185
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0041 0.0008
Onchocerca volvulus 0.0941 0.7762 0.9194
Entamoeba histolytica hypothetical protein 0.0149 0.1111 0.4863
Schistosoma mansoni importin beta-1 0.0029 0.0103 0.0069
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.033 0.0299
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0941 0.7762 0.7755
Echinococcus granulosus rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0023 0.005 0.0008
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.033 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0073
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.033 0.0886
Schistosoma mansoni cytochrome P450 0.0022 0.0049 0.0014
Brugia malayi hypothetical protein 0.0941 0.7762 0.7762
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0041 0.0008
Onchocerca volvulus 0.0941 0.7762 0.9194
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0057
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0041 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0097 0.0175
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0134
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0049 0.003
Onchocerca volvulus Tyrosine kinase homolog 0.0716 0.5878 0.6952
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0041 0.0008
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0105 0.0073
Schistosoma mansoni amine GPCR 0.0941 0.7762 0.7755
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.026 0.0663
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0132 0.0132
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.033 0.0296
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0169 0.039
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0057 0.005
Onchocerca volvulus 0.0941 0.7762 0.9194
Echinococcus multilocularis microtubule associated protein 2 0.077 0.6327 0.6315
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0941 0.7762 0.7755
Echinococcus granulosus roundabout 2 0.0043 0.0223 0.0191
Echinococcus multilocularis neuroglian 0.0028 0.0094 0.0062
Leishmania major cytochrome p450-like protein 0.0022 0.0049 0.003
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Mycobacterium ulcerans putative regulatory protein 0.0023 0.005 0.0012
Brugia malayi Serotonin receptor 0.0941 0.7762 0.7762
Echinococcus multilocularis mitogen activated protein kinase 3 0.0109 0.0777 0.0747
Schistosoma mansoni jumonji domain containing protein 0.006 0.0365 0.0332
Brugia malayi G-protein coupled receptor 0.0941 0.7762 0.7762
Echinococcus multilocularis neuropeptides capa receptor 0.0941 0.7762 0.7755
Schistosoma mansoni ran 0.0021 0.0039 0.0004
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0136 0.3418
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0008
Brugia malayi ecdysteroid receptor 0.0021 0.0041 0.0041
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0149
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0079 0.052 0.06
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.033 0.0374
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.1207 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.024 0.0604
Onchocerca volvulus 0.0941 0.7762 0.9194
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0027 0.0089 0.0057
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0169 0.0137
Loa Loa (eye worm) adenylyl cyclase 3 0.0214 0.1662 0.1635
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.033 1
Echinococcus granulosus peroxidasin 0.0027 0.0089 0.0057
Echinococcus granulosus dro:myosuppressin receptor 0.0941 0.7762 0.7755
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0049 0.003
Echinococcus multilocularis 0.0022 0.0049 0.0017
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.012 0.0088
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0049 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0777 0.0904
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0384 0.0438
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0166 0.0179
Onchocerca volvulus 0.0941 0.7762 0.9194
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0066 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0136 0.0104
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0079 0.052 0.06
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0166 0.0946
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0855 0.8262
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0418 0.3369 1
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0855 0.0825
Loa Loa (eye worm) hypothetical protein 0.0028 0.0096 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0041 0.0041
Echinococcus multilocularis geminin 0.0367 0.2941 0.2918
Echinococcus granulosus neuroglian 0.0028 0.0094 0.0062
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0365 0.0334
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0368 0.0368
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.033 0.0874
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0041 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0166 0.0381
Leishmania major hypothetical protein, conserved 0.0036 0.0166 0.0381
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0348 0.0317
Echinococcus granulosus lamin 0.006 0.0368 0.0337
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0089 0.0057
Schistosoma mansoni single-minded 0.0056 0.0332 0.0298
Echinococcus multilocularis hemicentin 1 0.0027 0.0089 0.0057
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.033 0.0296
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0941 0.7762 0.7755
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.033 0.0299
Schistosoma mansoni nephrin 0.0027 0.0089 0.0055
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.033 0.0374
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0027 0.0089 0.0057
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.033 0.0874
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0854 0.0995
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0941 0.7762 0.7755
Schistosoma mansoni adenoreceptor 0.0941 0.7762 0.7755
Echinococcus granulosus contactin 0.0027 0.0089 0.0057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.2212 0.2187
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0066 0.1053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0041 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0041 0.0008
Echinococcus multilocularis serotonin receptor 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0079 0.052 0.0489
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Echinococcus granulosus tachykinin peptides receptor 99D 0.0941 0.7762 0.7755
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.033 0.0374
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0129 0.0941 0.0912
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Onchocerca volvulus 0.0042 0.0209 0.0208
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0136 0.029
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0079 0.052 0.0487
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0041 0.0008
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.1207 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0166 0.0179
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0854 0.0995
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0397 0.2822
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0041 0.0008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.014 0.0108
Schistosoma mansoni hypothetical protein 0.0053 0.0301 0.0268
Brugia malayi hypothetical protein 0.0941 0.7762 0.7762
Onchocerca volvulus 0.006 0.0368 0.0397
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0897 0.7398 0.7389
Onchocerca volvulus 0.0036 0.0166 0.0156
Brugia malayi Doublecortin family protein 0.0021 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0397 0.0397
Echinococcus multilocularis neuropeptide Y receptor 0.0941 0.7762 0.7755
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0418 0.3369 1
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.033 0.0874
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0204 0.0495
Echinococcus granulosus tm gpcr rhodopsin 0.0941 0.7762 0.7755
Echinococcus multilocularis mitogen activated protein kinase 0.0109 0.0777 0.0747
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0041 0.0006
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0136 0.029
Onchocerca volvulus 0.0941 0.7762 0.9194
Echinococcus multilocularis dro:myosuppressin receptor 0.0941 0.7762 0.7755
Schistosoma mansoni myosin xvIII 0.0941 0.7762 0.7755
Onchocerca volvulus 0.0036 0.0166 0.0156
Schistosoma mansoni neuropeptide receptor 0.0941 0.7762 0.7755
Brugia malayi Melatonin receptor type 1A 0.0941 0.7762 0.7762
Echinococcus multilocularis peroxidasin 0.0027 0.0089 0.0057
Echinococcus granulosus tm gpcr rhodopsin 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0057
Loa Loa (eye worm) hypothetical protein 0.0129 0.0941 0.0912
Echinococcus multilocularis rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0089 0.0089
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.1219 0.119
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0041 0.0006
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0941 0.7762 0.7755
Loa Loa (eye worm) TYRA-2 protein 0.0941 0.7762 0.7755
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0397 0.1076
Brugia malayi AKH receptor 0.0941 0.7762 0.7762
Echinococcus multilocularis neuropeptides capa receptor 0.0941 0.7762 0.7755
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0041 0.0006
Loa Loa (eye worm) G-protein coupled receptor 0.0941 0.7762 0.7755
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0941 0.7762 0.7755
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0941 0.7762 0.7762
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.024 0.0604
Schistosoma mansoni hypothetical protein 0.0022 0.0049 0.0014
Brugia malayi Prion-like- 0.0027 0.0089 0.0089
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0136 0.0491
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0941 0.7762 0.7755
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0166 0.1197
Brugia malayi putative neuropeptide receptor NPR1 0.0941 0.7762 0.7762
Schistosoma mansoni neuropeptide receptor 0.0941 0.7762 0.7755
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.2024 0.1998
Echinococcus granulosus biogenic amine 5HT receptor 0.0941 0.7762 0.7755
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2243 0.2645
Schistosoma mansoni hypothetical protein 0.0941 0.7762 0.7755
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0941 0.7762 0.7762
Plasmodium vivax importin-beta 2, putative 0.0029 0.0103 0.0206
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0166 0.0179
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0136 0.0101
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0204 0.0172
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0134
Echinococcus granulosus serotonin receptor 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0258 0.2024 0.1998
Brugia malayi hypothetical protein 0.0021 0.0035 0.0035
Brugia malayi hypothetical protein 0.0024 0.0066 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0041 0.0008
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.026 0.029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0008
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.2243 1
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.033 0.0874
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Echinococcus multilocularis hemicentin 1 0.0027 0.0089 0.0057
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0041 0.0006
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0136 0.0104
Brugia malayi ORL1-like opioid receptor 0.0941 0.7762 0.7762
Echinococcus granulosus roundabout 2 0.0027 0.0089 0.0057
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.024 0.0604
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0059 0.0359 0.0328
Trypanosoma brucei protein kinase, putative 0.0109 0.0777 0.2216
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0941 0.7762 0.7755
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0049 0.0017
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0204 0.0224
Brugia malayi Importin beta-1 subunit 0.0029 0.0103 0.0103
Mycobacterium leprae Probable lipase LipE 0.0036 0.0166 0.1197
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0941 0.7762 0.7755
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0854 0.0995
Loa Loa (eye worm) hypothetical protein 0.0043 0.0223 0.0191
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0135
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0855 0.0823
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0027 0.0089 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0122 0.009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.2212 0.2187
Schistosoma mansoni neuropeptide f receptor 76f 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0941 0.7762 0.7755
Echinococcus granulosus importin subunit beta 1 0.0029 0.0103 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0035 0.0002
Echinococcus granulosus roundabout 2 0.0027 0.0089 0.0057
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Echinococcus granulosus lamin dm0 0.006 0.0368 0.0337
Loa Loa (eye worm) hypothetical protein 0.0056 0.033 0.0299
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0941 0.7762 0.7755
Echinococcus granulosus histone lysine methyltransferase setb 0.0129 0.0941 0.0912
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0941 0.7762 0.7755
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0103 0.0071
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0169 0.0972
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0397 0.0364
Brugia malayi Tachykinin-like peptides receptor 99D 0.0941 0.7762 0.7762
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.1207 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0109 0.0777 0.0747
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.033 0.033
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1206 0.9993 0.9993
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0135
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0169 0.039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0066 0.0033
Schistosoma mansoni lamin 0.006 0.0368 0.0335
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0109 0.0777 0.2216
Entamoeba histolytica hypothetical protein 0.0149 0.1111 0.4863
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0941 0.091
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0018
Schistosoma mansoni hypothetical protein 0.0367 0.2941 0.2916
Brugia malayi RE15519p 0.0941 0.7762 0.7762
Schistosoma mansoni neuropeptide F-like receptor 0.0941 0.7762 0.7755
Echinococcus granulosus sex peptide receptor 0.0941 0.7762 0.7755
Schistosoma mansoni amine GPCR 0.0941 0.7762 0.7755
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0105 0.0073
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0855 0.0997
Trypanosoma brucei unspecified product 0.0028 0.0097 0.0175
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0941 0.7762 0.7762
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0941 0.7762 0.7755
Schistosoma mansoni cell adhesion molecule 0.0031 0.0122 0.0088
Brugia malayi Inositol-1 0.0037 0.0169 0.0169
Brugia malayi hypothetical protein 0.0941 0.7762 0.7762
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0027 0.0089 0.0057
Mycobacterium ulcerans beta-lactamase 0.0036 0.0166 0.0946
Echinococcus multilocularis somatostatin receptor 0.0941 0.7762 0.7755
Echinococcus multilocularis roundabout 2 0.0043 0.0223 0.0191
Brugia malayi Cytochrome P450 family protein 0.0022 0.0049 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0041 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0941 0.7762 0.7755
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni inositol monophosphatase 0.0037 0.0169 0.0135
Echinococcus multilocularis fmrfamide receptor 0.0941 0.7762 0.7755
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.033 0.0874
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0091 0.0623 0.07
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.033 0.0299
Schistosoma mansoni growth hormone secretagogue receptor 0.0941 0.7762 0.7755
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0166 0.0662
Mycobacterium leprae conserved hypothetical protein 0.0023 0.005 0.0015
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.033 0.033
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0041 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0204 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.033 0.0374
Schistosoma mansoni lipoxygenase 0.0058 0.0348 0.0315
Brugia malayi hypothetical protein 0.0188 0.1443 0.1443
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0041 0.0041
Echinococcus granulosus Solute carrier family 22 5 0.1185 0.9814 0.9813
Mycobacterium tuberculosis Conserved protein 0.0036 0.0166 0.0662
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0028 0.0098 0.0065
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0365 0.0334
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0348 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0049 0.0017
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0049 0.003
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.2562 0.7577
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0397 0.0364
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0129 0.027
Schistosoma mansoni alpha-1 adrenergic receptor 0.0941 0.7762 0.7755
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0129 0.5
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0204 0.0879
Brugia malayi hypothetical protein 0.0021 0.0035 0.0035
Brugia malayi RNA binding protein 0.0064 0.0397 0.0397
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0397 0.1076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.2212 0.2185
Echinococcus multilocularis GPCR, family 2 0.0033 0.014 0.0108
Echinococcus granulosus g protein coupled receptor 0.0941 0.7762 0.7755
Echinococcus multilocularis roundabout 2 0.0027 0.0089 0.0057
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.033 0.0374
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0204 0.1256
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni neuropeptide receptor 0.0941 0.7762 0.7755
Mycobacterium ulcerans hypothetical protein 0.0036 0.0166 0.0946
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0873 0.0843
Brugia malayi hypothetical protein 0.0941 0.7762 0.7762
Echinococcus multilocularis fmrfamide receptor 0.0941 0.7762 0.7755
Loa Loa (eye worm) PDE1B protein 0.1207 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.012 0.012
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0039 0.0013
Schistosoma mansoni hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni opsin-like receptor 0.0941 0.7762 0.7755
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0418 0.3369 1
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0041 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2243 0.2645
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0941 0.7762 0.7755
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0136 0.029
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.2024 0.1998
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0129 0.0941 0.271
Echinococcus multilocularis G protein coupled receptor 139 0.0941 0.7762 0.7755
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0118 0.0854 0.0995
Giardia lamblia hypothetical protein 0.0056 0.033 0.132
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0368 0.0337
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0855 0.0825
Mycobacterium ulcerans putative regulatory protein 0.0023 0.005 0.0012
Echinococcus granulosus adenylate cyclase 9 0.0091 0.0623 0.0592
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0136 0.0104
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0041 0.0006
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0096 0.0663 0.077
Brugia malayi Adenylyl cyclase protein 0.0091 0.0623 0.0623
Brugia malayi isocitrate dehydrogenase 0.0033 0.0136 0.0136
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0118 0.0854 0.0822
Loa Loa (eye worm) hypothetical protein 0.0091 0.0623 0.0592
Schistosoma mansoni biogenic amine receptor 0.0941 0.7762 0.7755
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0118 0.0854 0.0995
Brugia malayi G-protein coupled receptor 0.0941 0.7762 0.7762
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0166 0.0166
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0056 0.033 0.0299
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0397 0.1976
Echinococcus granulosus neuropeptide Y receptor 0.0941 0.7762 0.7755
Onchocerca volvulus 0.0941 0.7762 0.9194
Echinococcus multilocularis orexin receptor type 2 0.0941 0.7762 0.7755
Onchocerca volvulus 0.0941 0.7762 0.9194
Echinococcus granulosus g protein coupled receptor 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0134
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0855 0.0997
Brugia malayi beta-lactamase family protein 0.0036 0.0166 0.0166
Schistosoma mansoni cell adhesion molecule 0.0027 0.0089 0.0055
Echinococcus granulosus biogenic amine 5HT receptor 0.0941 0.7762 0.7755
Echinococcus multilocularis g protein coupled receptor 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0941 0.7762 0.7755
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0397 0.0364
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0057
Echinococcus granulosus neuropeptide receptor A26 0.0941 0.7762 0.7755
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0031 0.0122 0.009
Echinococcus granulosus mitogen activated protein kinase 0.0109 0.0777 0.0747
Brugia malayi hypothetical protein 0.0149 0.1111 0.1111
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0941 0.7762 0.7755
Brugia malayi hypothetical protein 0.0941 0.7762 0.7762
Mycobacterium tuberculosis Conserved protein 0.0036 0.0166 0.0662
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0041 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Brugia malayi hypothetical protein 0.0258 0.2024 0.2024
Schistosoma mansoni survival motor neuron protein 0.0053 0.0301 0.0268
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.052 0.06
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0039 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0135
Onchocerca volvulus 0.0087 0.059 0.0661
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0041 0.0008
Onchocerca volvulus 0.0129 0.0941 0.1079
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni histamine h1 receptor 0.0941 0.7762 0.7755
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0166 0.0393
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.118 0.1152
Echinococcus multilocularis neuropeptide receptor 0.0941 0.7762 0.7755
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0941 0.7762 0.7755
Onchocerca volvulus 0.0941 0.7762 0.9194
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni hypothetical protein 0.0941 0.7762 0.7755
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0091 0.0623 0.07
Echinococcus multilocularis rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Echinococcus multilocularis adenylate cyclase 9 0.0091 0.0623 0.0592
Echinococcus granulosus tyrosine protein kinase otk 0.0027 0.0089 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0166 0.0179
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.033 0.0296
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0041 0.0008
Schistosoma mansoni roundabout 0.0027 0.0089 0.0055
Loa Loa (eye worm) neuropeptide F receptor 0.0941 0.7762 0.7755
Brugia malayi intermediate filament protein 0.006 0.0368 0.0368
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0855 0.2449
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0397 0.0366
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0135
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0744 0.0744
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0204 0.0495
Loa Loa (eye worm) hypothetical protein 0.0188 0.1443 0.1415
Brugia malayi cytochrome P450 0.0022 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0008
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0118 0.0854 0.0995
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0049 0.003
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0136 0.029
Echinococcus multilocularis musashi 0.006 0.0368 0.0337
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0109 0.0777 0.2216
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0397 0.0364
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0941 0.7762 0.7755
Echinococcus granulosus g-protein coupled receptor 0.0941 0.7762 0.7755
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0096 0.0663 0.1875
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.1812 1
Onchocerca volvulus 0.0941 0.7762 0.9194
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.2453 0.2429
Schistosoma mansoni opsin-like receptor 0.0941 0.7762 0.7755
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0049 0.003
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0855 0.3701
Brugia malayi nuclear receptor NHR-88 0.0021 0.0041 0.0041
Echinococcus granulosus peptide allatostatin:somatostatin 0.0941 0.7762 0.7755
Echinococcus multilocularis g protein coupled receptor 0.0941 0.7762 0.7755
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Echinococcus granulosus 7tm_1 domain containing protein 0.0941 0.7762 0.7755
Schistosoma mansoni hypothetical protein 0.0033 0.014 0.0106
Brugia malayi Dopamine receptor 0.0941 0.7762 0.7762
Echinococcus granulosus allatostatin A receptor 0.0941 0.7762 0.7755
Mycobacterium ulcerans lipase LipD 0.0036 0.0166 0.0946
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0534 0.0503
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0041 0.0041
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0941 0.7762 0.7755
Brugia malayi RNA, U transporter 1 0.0082 0.0551 0.0551
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0855 0.6527
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.033 0.0886
Brugia malayi hypoxia-induced factor 1 0.0174 0.132 0.132
Echinococcus multilocularis neuropeptide receptor A26 0.0941 0.7762 0.7755
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0118 0.0854 0.0824
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0134
Echinococcus multilocularis rhodopsin orphan GPCR 0.0941 0.7762 0.7755
Onchocerca volvulus 0.0941 0.7762 0.9194
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0103 0.0193
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.005 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0873 0.0843
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0023 0.005 0.0008
Leishmania major importin beta-1 subunit, putative 0.0023 0.0057 0.0055
Loa Loa (eye worm) hypothetical protein 0.0029 0.0103 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0135
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.024 0.0604
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2243 0.2645
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.1283 0.7002
Brugia malayi Pre-SET motif family protein 0.0897 0.7398 0.7398
Schistosoma mansoni transcription factor LCR-F1 0.0149 0.1111 0.108
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.033 0.0874
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0041 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0204 0.1256
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0855 0.0997
Brugia malayi hypothetical protein 0.0941 0.7762 0.7762
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0129 0.3191
Leishmania major mitochondrial DNA polymerase beta 0.0322 0.2562 0.7577
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.033 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.033 0.0296
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0041 0.0006
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0855 0.0825
Echinococcus granulosus dna polymerase eta 0.0041 0.0204 0.0172
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0137 0.0497
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0209 0.0178
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0041 0.0041
Loa Loa (eye worm) neuropeptide F receptor 0.0941 0.7762 0.7755
Echinococcus granulosus neuropeptides capa receptor 0.0941 0.7762 0.7755
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.033 0.0299
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0089 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Toxoplasma gondii hypothetical protein 0.0052 0.0296 0.0772
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0166 0.0381
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.2212 0.2187
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.014 0.014
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0129 0.0283
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.026 0.0663
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Toxoplasma gondii hypothetical protein 0.0023 0.005 0.0034
Leishmania major cytochrome p450-like protein 0.0022 0.0049 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.033 0.0874
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0118 0.0854 0.2447
Echinococcus multilocularis G-protein coupled receptor, putative 0.0941 0.7762 0.7755
Brugia malayi Pre-SET motif family protein 0.0129 0.0941 0.0941
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.005 0.0042
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.033 0.0874
Brugia malayi hypothetical protein 0.0941 0.7762 0.7762
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.033 0.0296
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1024 0.79
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0129 0.0408
Echinococcus multilocularis lamin dm0 0.006 0.0368 0.0337
Onchocerca volvulus Netrin receptor homolog 0.0028 0.0092 0.0069
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0149 0.1111 0.1082
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0118 0.0854 0.0824
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.026 0.0228
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0166 0.0132
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Echinococcus granulosus G protein coupled receptor 139 0.0941 0.7762 0.7755
Plasmodium falciparum importin beta, putative 0.0029 0.0103 0.232
Loa Loa (eye worm) hypothetical protein 0.0102 0.0718 0.0688
Brugia malayi jmjC domain containing protein 0.006 0.0365 0.0365
Brugia malayi PAS domain containing protein 0.0056 0.0332 0.0332
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0049 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0204 0.0495
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0777 0.0745
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.033 0.0874
Echinococcus granulosus alpha 1A adrenergic receptor 0.0941 0.7762 0.7755
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0041 0.0008
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0027 0.0089 0.0057
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0777 0.0904
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0941 0.7762 0.7755
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0166 0.0946
Brugia malayi sulfakinin receptor protein 0.0941 0.7762 0.7762
Onchocerca volvulus 0.0941 0.7762 0.9194
Echinococcus granulosus netrin receptor unc 5 0.0031 0.012 0.0088
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0169 0.039
Loa Loa (eye worm) hypothetical protein 0.0941 0.7762 0.7755
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0397 0.0364
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0166 0.0662
Onchocerca volvulus 0.0941 0.7762 0.9194
Trichomonas vaginalis ran, putative 0.0021 0.0039 0.0028
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0057 0.005
Echinococcus multilocularis dna polymerase eta 0.0041 0.0204 0.0172
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0109 0.0777 0.2216
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0129 0.0135
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0941 0.7762 0.7755
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0049 0.003
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0027 0.0089 0.0057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0057
Schistosoma mansoni biogenic amine receptor 0.0941 0.7762 0.7755
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0129 0.0941 0.0912
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0118 0.0854 0.0995
Leishmania major cytochrome p450-like protein 0.0022 0.0049 0.003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0744 0.0744
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0209 0.0209
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0941 0.7762 0.7755
Schistosoma mansoni microtubule-associated protein tau 0.077 0.6327 0.6315
Brugia malayi Latrophilin receptor protein 2 0.0033 0.014 0.014
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0941 0.7762 0.7755
Echinococcus granulosus intermediate filament protein 0.006 0.0368 0.0337
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0066 0.1053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.2212 0.2187

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -7.75 Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells ChEMBL. 14741270
Ki (binding) = -6.78 Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes ChEMBL. 14741270
Ki (binding) = 18 nM Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells ChEMBL. 14741270
Ki (binding) = 18 nM Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells ChEMBL. 14741270
Ki (binding) = 160 nM Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes ChEMBL. 14741270
Ki (binding) = 160 nM Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes ChEMBL. 14741270
Log Ki (binding) = 6.78 Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranes ChEMBL. 14741270
Log Ki (binding) = 7.75 Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cells ChEMBL. 14741270

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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