Detailed information for compound 279678

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.379 | Formula: C21H19NO5
  • H donors: 0 H acceptors: 1 LogP: 2.95 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N1C2Cc3c(C1Cc1c2cc2OCOc2c1)cc1c(c3)OCO1
  • InChi: 1S/C21H19NO5/c1-2-21(23)22-15-3-11-5-17-19(26-9-24-17)7-13(11)16(22)4-12-6-18-20(8-14(12)15)27-10-25-18/h5-8,15-16H,2-4,9-10H2,1H3
  • InChiKey: HRFFCOVDJJFFDN-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0009 0.0018
Schistosoma mansoni calpain C (C02 family) 0.0022 0.0035 0.0107
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0055 0.0119 0.0654
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0146 0.0456
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0009 0.0098
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0098
Brugia malayi hypothetical protein 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0703 0.1808 0.1808
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.004 0.2311
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0093 0.0711
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0007 0.0335
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0016 0.0016
Trichomonas vaginalis methionyl-tRNA synthetase, putative 0.0014 0.0013 0.0158
Loa Loa (eye worm) hypothetical protein 0.0415 0.1057 0.1057
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0035 0.2001
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0146 0.0456
Loa Loa (eye worm) hypothetical protein 0.0083 0.0192 0.0192
Leishmania major histone deacetylase, putative 0.0012 0.0007 0.0359
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0041 0.051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Echinococcus granulosus Chromobox protein 3 0.0012 0.0009 0.0024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0164 0.0513
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0039 0.2257
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0004 0.0009
Brugia malayi calpain family protein 1 0.0059 0.0131 0.013
Echinococcus granulosus expressed protein 0.001 0.0002 0.0002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0114 0.6645
Trypanosoma brucei histone deacetylase 2 0.0012 0.0007 0.0359
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0039 0.0091
Loa Loa (eye worm) hypothetical protein 0.0415 0.1057 0.1057
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0034 0.1924
Loa Loa (eye worm) helicase 0.0012 0.0009 0.0009
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0256 0.0255
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0114 0.0268
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0009 0.0098
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0004 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0126 0.0125
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0095 0.1213
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0002 0.0002
Plasmodium vivax histone deacetylase, putative 0.0012 0.0007 0.0359
Schistosoma mansoni elf1 0.001 0.0004 0.0009
Entamoeba histolytica hypothetical protein 0.0035 0.0068 0.0864
Onchocerca volvulus 0.0064 0.0143 0.0789
Leishmania major histone deacetylase, putative 0.0012 0.0007 0.0359
Schistosoma mansoni integrin alpha-ps 0.0035 0.0068 0.021
Brugia malayi beta-lactamase family protein 0.0074 0.017 0.017
Loa Loa (eye worm) zinc carboxypeptidase 0.0009 0.0001 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.017 0.2194
Plasmodium vivax SET domain protein, putative 0.0029 0.0052 0.3035
Leishmania major hypothetical protein 0.0014 0.0013 0.072
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0009 0.0098
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.004 0.281
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0506 0.0506
Echinococcus multilocularis hypothetical protein 0.0022 0.0035 0.0081
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.3846 1 1
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0004 0.0009
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0007 0.0335
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0054 0.0412
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0019 0.0019
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0034 0.0253
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0012 0.0007 0.0063
Echinococcus granulosus histone deacetylase 1 0.0041 0.0084 0.026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0774 1
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.001 0.0002 0.0002
Mycobacterium ulcerans beta-lactamase 0.0074 0.017 0.1231
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0039 0.2257
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0114 0.1458
Schistosoma mansoni nocturnin 0.0012 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Echinococcus granulosus ephrin type A receptor 4 A 0.0065 0.0145 0.0454
Schistosoma mansoni hypothetical protein 0.0318 0.0805 0.2529
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0114 0.0873
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0035 0.2001
Brugia malayi Histone deacetylase family protein 0.0012 0.0007 0.0006
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.009 0.021 0.0659
Entamoeba histolytica histone deacetylase, putative 0.0041 0.0084 0.1061
Loa Loa (eye worm) zinc carboxypeptidase 0.0009 0.0001 0.0001
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0172 0.222
Onchocerca volvulus 0.0033 0.0063 0.0341
Echinococcus multilocularis integrin alpha 3 0.0115 0.0276 0.0655
Echinococcus multilocularis snurportin 1 0.0318 0.0805 0.1912
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0063
Onchocerca volvulus Phospholipase A2 homolog 0.0703 0.1808 1
Loa Loa (eye worm) hypothetical protein 0.0504 0.1291 0.1291
Loa Loa (eye worm) POT family protein 0.0165 0.0408 0.0408
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.0372 0.1167
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0004 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0013 0.072
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0074 0.017 0.017
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0035 0.2001
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0009 0.0008
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0186 0.0461 0.1447
Loa Loa (eye worm) fli-1 protein 0.0218 0.0546 0.0546
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0009 0.0448
Echinococcus granulosus snurportin 1 0.0318 0.0805 0.2529
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0009 0.0098
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0126 0.1554
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0146 0.0146
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0009 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0226 0.0565 0.1342
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0007 0.0073
Schistosoma mansoni trimeric G-protein alpha o subunit 0.001 0.0002 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0106 0.0105
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.017 0.2194
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0039 0.0495
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0009 0.0098
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0084 0.107
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0044
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0131 0.041
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.017 0.1276
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.017 0.0533
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0024 0.0039 0.2734
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0096 0.0227 0.0711
Loa Loa (eye worm) zinc metallopeptidase 4 0.009 0.021 0.021
Echinococcus multilocularis protein C ets 2 0.001 0.0004 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0009 0.0098
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.001 0.0002 0.0002
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0009 0.0024
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0294 0.0294
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0009
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0035 0.2001
Loa Loa (eye worm) histone deacetylase 7A 0.0012 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0086 0.1105
Trypanosoma brucei protein kinase, putative 0.0053 0.0114 0.6645
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.0121
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0081 0.019
Brugia malayi histone deacetylase 1 (HD1) 0.0041 0.0084 0.0083
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0002 0.0002
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.0272 0.0271
Echinococcus granulosus endothelin converting enzyme 1 0.0504 0.1291 0.4058
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0098
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0039 0.0091
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0055 0.0119 0.0281
Echinococcus multilocularis histone deacetylase 8 0.0012 0.0007 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0041 0.237
Loa Loa (eye worm) hypothetical protein 0.0504 0.1291 0.1291
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.0039 0.012
Trypanosoma brucei histone deacetylase 3 0.0012 0.0007 0.0359
Giardia lamblia Fructose-bisphosphate aldolase 0.0306 0.0774 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0126 0.0928
Loa Loa (eye worm) zinc carboxypeptidase 0.0009 0.0001 0.0001
Schistosoma mansoni histone deacetylase 4 5 0.0012 0.0007 0.0019
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0007 0.0018
Leishmania major tyrosyl or methionyl-tRNA synthetase-like protein 0.0014 0.0013 0.072
Giardia lamblia Methionyl-tRNA synthetase 0.0014 0.0013 0.0158
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0002 0.0002
Echinococcus granulosus lamin 0.0028 0.005 0.0154
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.001 0.0002 0.0001
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0039 0.2257
Echinococcus multilocularis GPCR, family 2 0.005 0.0106 0.025
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0009 0.0008
Loa Loa (eye worm) intermediate filament protein 0.0028 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0504 0.1291 0.1291
Echinococcus granulosus calpain A 0.0062 0.0138 0.0432
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0146 0.0146
Mycobacterium ulcerans hypothetical protein 0.0074 0.017 0.1231
Echinococcus granulosus histone deacetylase 3 0.0041 0.0084 0.026
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0126 0.7368
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0053 0.0114 0.0114
Echinococcus multilocularis aminopeptidase N 0.0024 0.0039 0.0091
Schistosoma mansoni intermediate filament proteins 0.0028 0.005 0.0154
Brugia malayi Fli-1 protein 0.0218 0.0546 0.0545
Leishmania major kinesin, putative 0.0016 0.0017 0.0965
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1622 0.4205 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, beta chain PheT 0.0014 0.0013 0.0051
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.0774 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0019 0.1039
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.001 0.0002 0.001
Schistosoma mansoni tyrosyl-tRNA synthetase 0.0032 0.006 0.0187
Brugia malayi Histone deacetylase family protein 0.0012 0.0007 0.0006
Brugia malayi hypothetical protein 0.0035 0.0068 0.0068
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0025 0.1406
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.001 0.0002 0.0001
Onchocerca volvulus 0.001 0.0002 0.0004
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0039 0.012
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0007 0.0018
Plasmodium vivax histone deacetylase 2, putative 0.0012 0.0007 0.0359
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0025 0.0141
Plasmodium vivax importin-beta 2, putative 0.003 0.0054 0.3133
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.0565 0.1774
Loa Loa (eye worm) hypothetical protein 0.0157 0.0385 0.0385
Schistosoma mansoni hypothetical protein 0.0107 0.0256 0.0802
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0009 0.0098
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.0385 0.0385
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.009 0.021 0.0659
Toxoplasma gondii histone deacetylase HDAC4 0.0012 0.0007 0.0047
Onchocerca volvulus 0.0024 0.0039 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0146 0.0456
Entamoeba histolytica protein kinase, putative 0.0016 0.0019 0.0218
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0039 0.0204
Onchocerca volvulus 0.0041 0.0084 0.0462
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0034 0.1924
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0774 1
Loa Loa (eye worm) hypothetical protein 0.0408 0.104 0.104
Echinococcus granulosus intermediate filament protein 0.0028 0.005 0.0154
Schistosoma mansoni hypothetical protein 0.0035 0.0068 0.0212
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0009 0.0098
Echinococcus granulosus tyrosyl tRNA synthetase 0.0032 0.006 0.0187
Schistosoma mansoni histone deacetylase 1 2 3 0.0012 0.0007 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0098
Schistosoma mansoni ran 0.0022 0.0034 0.0103
Schistosoma mansoni histone deacetylase 0.0041 0.0084 0.026
Onchocerca volvulus 0.0012 0.0007 0.0031
Toxoplasma gondii histone deacetylase HDAC2 0.0041 0.0084 0.0641
Trypanosoma brucei tyrosyl/methionyl-tRNA synthetase, putative 0.0014 0.0013 0.072
Loa Loa (eye worm) hypothetical protein 0.0033 0.0063 0.0063
Trypanosoma cruzi histone deacetylase, putative 0.0012 0.0007 0.0359
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0114 0.1458
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0114 0.1458
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0034 0.0034
Trypanosoma cruzi histone deacetylase, putative 0.0012 0.0007 0.0359
Leishmania major importin beta-1 subunit, putative 0.0024 0.0039 0.2267
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0007 0.0335
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0009 0.0008
Loa Loa (eye worm) calpain 0.0022 0.0035 0.0035
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0022 0.0035 0.2001
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0039 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.0158
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0156 0.2005
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0035 0.2001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0007 0.0006
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.001 0.0002 0.0002
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0009 0.0024
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0114 0.0354
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0002 0.0002
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0063
Loa Loa (eye worm) RNA binding protein 0.0065 0.0146 0.0146
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0039 0.2257
Brugia malayi hypothetical protein 0.0024 0.004 0.0039
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0084 0.107
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0084 0.107
Entamoeba histolytica tyrosyl-tRNA synthetase, putative 0.0018 0.0024 0.0286
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.001 0.0002 0.0002
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0007 0.0073
Onchocerca volvulus 0.001 0.0002 0.0004
Toxoplasma gondii histone deacetylase HDAC1 0.0012 0.0007 0.0047
Echinococcus granulosus calpain 7 C02 family 0.0022 0.0035 0.0107
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0095 0.1213
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0039 0.012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0041 0.051
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0366 0.2798
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0106 0.0106
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0084 0.107
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0232 0.0582 0.1829
Toxoplasma gondii aminopeptidase n, putative 0.0024 0.0039 0.0297
Loa Loa (eye worm) hypothetical protein 0.0033 0.0061 0.0061
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.017 0.0403
Loa Loa (eye worm) hypothetical protein 0.0415 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Echinococcus multilocularis calpain 7 (C02 family) 0.0022 0.0035 0.0081
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0114 0.6645
Mycobacterium ulcerans zinc metalloprotease 0.0504 0.1291 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0107 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.0565 0.1774
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0014 0.0013 0.0148
Schistosoma mansoni lamin 0.0028 0.005 0.0154
Schistosoma mansoni synaptojanin 0.0012 0.0007 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0098
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0012 0.0007 0.0335
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0039 0.2257
Trypanosoma cruzi tyrosyl or methionyl-tRNA synthetase, putative 0.0014 0.0013 0.072
Echinococcus granulosus lamin dm0 0.0028 0.005 0.0154
Loa Loa (eye worm) peptidase family M13 containing protein 0.0408 0.104 0.104
Brugia malayi calpain 5 0.0016 0.0017 0.0016
Trypanosoma cruzi tyrosyl-tRNA synthetase, putative 0.0018 0.0024 0.135
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0012 0.0007 0.0335
Echinococcus multilocularis lamin 0.0028 0.005 0.0117
Trypanosoma brucei histone deacetylase 1 0.0041 0.0084 0.4878
Schistosoma mansoni hypothetical protein 0.0096 0.0227 0.0711
Toxoplasma gondii histone deacetylase HDAC3 0.0041 0.0084 0.0641
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0232 0.0582 0.1383
Brugia malayi RNA, U transporter 1 0.0085 0.0197 0.0196
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0007 0.0006
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0002 0.0002
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0002 0.0002
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0039 0.0497
Schistosoma mansoni histone deacetylase hda2 0.0012 0.0007 0.0019
Echinococcus granulosus geminin 0.1229 0.318 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0146 0.0456
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0041 0.0219
Brugia malayi calpain 7 0.0022 0.0035 0.0034
Schistosoma mansoni hypothetical protein 0.1229 0.318 1
Echinococcus granulosus histone deacetylase 6 0.0012 0.0007 0.0019
Schistosoma mansoni synaptojanin 0.0012 0.0007 0.0018
Brugia malayi beta-lactamase 0.0074 0.017 0.017
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0007 0.0335
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0146 0.0345
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0018 0.0024 0.0296
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0009 0.0024
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0156 0.9177
Onchocerca volvulus 0.0024 0.0039 0.0212
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0083 0.1053
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0002 0.001
Echinococcus multilocularis integrin alpha ps 0.0067 0.0152 0.0359
Loa Loa (eye worm) hypothetical protein 0.0074 0.017 0.017
Entamoeba histolytica hypothetical protein 0.0035 0.0068 0.0864
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.0385 0.0385
Brugia malayi intermediate filament protein 0.0028 0.005 0.0049
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0039 0.0497
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0068 0.0212
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0007 0.0335
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0009 0.0448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0774 1
Schistosoma mansoni hypothetical protein 0.0012 0.0007 0.0018
Brugia malayi transcription factor E74 isoform 0.001 0.0004 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0035 0.2001
Loa Loa (eye worm) peptidase family M13 containing protein 0.0408 0.104 0.104
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0126 0.0297
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0035 0.2001
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0041 0.0269
Brugia malayi hypothetical protein 0.0012 0.0009 0.0008
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0024 0.0039 0.2734
Onchocerca volvulus 0.0012 0.0009 0.0042
Trypanosoma brucei kinesin, putative 0.0016 0.0017 0.0965
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0114 0.6645
Brugia malayi Cytochrome P450 family protein 0.0016 0.0019 0.0018
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0114 0.6645
Loa Loa (eye worm) hypothetical protein 0.0415 0.1057 0.1057
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0002 0.0001
Echinococcus granulosus histone deacetylase 0.0012 0.0007 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0226 0.0565 0.1774
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0007 0.0006
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0009 0.0088
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0054 0.3133
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.0039 0.012
Brugia malayi Cytochrome P450 family protein 0.0016 0.0019 0.0018
Mycobacterium tuberculosis Conserved protein 0.0074 0.017 0.1276
Trypanosoma cruzi kinesin, putative 0.0016 0.0017 0.0965
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0039 0.0038
Giardia lamblia hypothetical protein 0.0012 0.0007 0.0073
Echinococcus multilocularis Chromo domain 0.0012 0.0009 0.0018
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0009 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.0158
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0007 0.0335
Mycobacterium leprae probable zinc metalloprotease 0.0504 0.1291 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0098
Schistosoma mansoni Mername-AA248 (C02 family) 0.0022 0.0035 0.0107
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0007 0.0335
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0024 0.0039 0.012
Echinococcus granulosus integrin alpha ps 0.0067 0.0152 0.0474
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0039 0.2257
Schistosoma mansoni calpain (C02 family) 0.0022 0.0035 0.0107
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0007 0.0335
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Brugia malayi peptidase family M13 containing protein 0.009 0.021 0.0209
Onchocerca volvulus 0.0012 0.0007 0.0031
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0019 0.0042
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0007 0.0006
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0093 0.5414
Schistosoma mansoni neprilysin 0.0096 0.0227 0.0711
Loa Loa (eye worm) calpain family protein 1 0.0044 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0007 0.0006
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0007 0.0335
Schistosoma mansoni neprilysin-2 (M13 family) 0.0186 0.0461 0.1447
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0009 0.0161
Onchocerca volvulus 0.0074 0.017 0.0938
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0035 0.2001
Loa Loa (eye worm) hypothetical protein 0.0118 0.0283 0.0283
Schistosoma mansoni hypothetical protein 0.0056 0.0122 0.0381
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.005 0.0106 0.033
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.017 0.2194
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0034 0.0033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.017 0.1231
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0012 0.0007 0.0335
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.017 0.0533
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0002 0.001
Brugia malayi G-protein alpha subunit 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0062 0.0137 0.0137
Echinococcus multilocularis calpain A 0.0062 0.0138 0.0327
Toxoplasma gondii tRNA binding domain-containing protein 0.0014 0.0013 0.0095
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0012 0.0007 0.0335
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0007 0.0013
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.0444 0.2452
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0774 1
Brugia malayi Ets-domain containing protein 0.0072 0.0164 0.0163
Echinococcus granulosus transcription factor Dp 1 0.004 0.0081 0.0251
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.009 0.0213
Schistosoma mansoni hypothetical protein 0.0096 0.0227 0.0711
Brugia malayi Latrophilin receptor protein 2 0.005 0.0106 0.0105
Schistosoma mansoni hypothetical protein 0.0096 0.0227 0.0711
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0004 0.0004
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0007 0.0073
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0126 0.7368
Leishmania major hypothetical protein, conserved 0.0074 0.017 1
Onchocerca volvulus 0.0025 0.0041 0.0222
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0007 0.0031
Loa Loa (eye worm) hypothetical protein 0.0179 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0074 0.017 0.017
Toxoplasma gondii peptidase family M13 protein 0.0504 0.1291 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0083 0.6409
Onchocerca volvulus 0.0055 0.0119 0.0654
Brugia malayi hypothetical protein 0.0208 0.052 0.0519
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0007 0.0018
Schistosoma mansoni histone deacetylase hda2 0.0012 0.0007 0.0019
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0084 0.4878
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0106 0.025
Schistosoma mansoni ets-related 0.0218 0.0546 0.1714
Brugia malayi Protein cec-1. 0.0012 0.0009 0.0008
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0186 0.0461 0.1447
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.1216 0.9416
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0007 0.0018
Schistosoma mansoni ets 0.001 0.0004 0.0009
Schistosoma mansoni chromobox protein 0.0012 0.0009 0.0024
Loa Loa (eye worm) beta-lactamase 0.0074 0.017 0.017
Toxoplasma gondii aminopeptidase N, putative 0.0024 0.0039 0.0297
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0093 0.0711
Brugia malayi Pre-SET motif family protein 0.0029 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0011
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0084 0.107
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0007 0.0018
Brugia malayi hypothetical protein 0.0024 0.0039 0.0038
Echinococcus multilocularis integrin alpha ps 0.0032 0.006 0.0142
Onchocerca volvulus 0.0074 0.017 0.0938
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.001 0.0002 0.0001
Brugia malayi hypothetical protein 0.0024 0.0039 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0009 0.0098
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0034 0.1924
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0041 0.0219
Mycobacterium leprae Probable lipase LipE 0.0074 0.017 0.1035
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0039 0.2267
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0579 0.7481
Onchocerca volvulus 0.0074 0.017 0.0938
Echinococcus granulosus leukotriene A 4 hydrolase 0.0232 0.0582 0.1829
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0007 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0039 0.2257
Trypanosoma brucei RNA editing exonuclease 2 0.0012 0.0007 0.0335
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0012 0.0007 0.0335
Loa Loa (eye worm) zinc carboxypeptidase 0.0009 0.0001 0.0001
Trypanosoma brucei histone deacetylase, putative 0.0012 0.0007 0.0359
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0034 0.0422
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Plasmodium vivax histone deacetylase, putative 0.0012 0.0007 0.0359
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0039 0.2257
Brugia malayi Peptidase family M13 containing protein 0.0504 0.1291 0.129
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0172 0.0172
Trypanosoma brucei tyrosyl-tRNA synthetase, putative 0.0014 0.0013 0.072
Entamoeba histolytica hypothetical protein 0.0012 0.0009 0.0088
Echinococcus multilocularis importin subunit beta 1 0.003 0.0054 0.0126
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0062 0.0138 0.0327
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0012 0.0007 0.0335
Echinococcus granulosus aminoacyl tRNA synthase complex interacting 0.0014 0.0013 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0026 0.1475
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0126 0.7368
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0186 0.0461 0.1447
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0041 0.0269
Schistosoma mansoni hypothetical protein 0.1229 0.318 1
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0004 0.0006
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0007 0.0007
Onchocerca volvulus 0.0024 0.0039 0.0212
Brugia malayi TATA binding protein associated factor 0.0024 0.0039 0.0038
Leishmania major hypothetical protein, conserved 0.0014 0.0013 0.072
Entamoeba histolytica hypothetical protein 0.0012 0.0009 0.0088
Onchocerca volvulus 0.0055 0.0119 0.0654
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0041 0.0219
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0083 0.1062
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0012 0.0035
Leishmania major GTP-binding protein, putative 0.0022 0.0034 0.1924
Brugia malayi POT family protein 0.0165 0.0408 0.0407
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0774 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0009 0.0088
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0007 0.0335
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.004 0.2311
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0004 0.0003
Toxoplasma gondii histone deacetylase HDAC5 0.0012 0.0007 0.0047
Schistosoma mansoni hypothetical protein 0.005 0.0106 0.033
Echinococcus multilocularis chromobox protein 1 0.0075 0.0172 0.0408
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0004 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0084 0.0263
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0024 0.0039 0.0091
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0039 0.2257
Plasmodium vivax tyrosine--tRNA ligase, putative 0.0018 0.0024 0.135
Echinococcus granulosus integrin alpha 3 0.0115 0.0276 0.0866
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0114 0.1458
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0007 0.0006
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0007 0.0073
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0063
Schistosoma mansoni gabp alpha 0.0072 0.0164 0.0513
Brugia malayi methionyl-tRNA synthetase 0.0014 0.0013 0.0012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0095 0.0519
Treponema pallidum methionyl-tRNA synthetase 0.0014 0.0013 0.0085
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.0039 0.2257
Echinococcus multilocularis chromobox protein 1 0.0075 0.0172 0.0408
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0126 0.0882
Brugia malayi MH2 domain containing protein 0.0122 0.0294 0.0293
Echinococcus multilocularis chromobox protein 2 0.0012 0.0009 0.0018
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0039 0.0091
Echinococcus granulosus chromobox protein 1 0.0075 0.0172 0.054
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0014 0.0013 0.0013
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0126 1
Loa Loa (eye worm) calpain family protein 1 0.0059 0.0131 0.0131
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.009 0.021 0.0659
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0009 0.0059
Brugia malayi Importin beta-1 subunit 0.003 0.0054 0.0053
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0164 0.0164
Schistosoma mansoni ran 0.0022 0.0034 0.0103
Loa Loa (eye worm) TK/EPH protein kinase 0.0082 0.0191 0.0191
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0004 0.0009
Mycobacterium tuberculosis Conserved protein 0.0074 0.017 0.1276
Schistosoma mansoni ephrin receptor 0.0065 0.0145 0.0454
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0025 0.1523
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0774 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0035 0.2001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Brugia malayi TAR-binding protein 0.0065 0.0146 0.0145
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0052 0.0399
Loa Loa (eye worm) histone deacetylase 11 0.0012 0.0007 0.0007
Trypanosoma cruzi histone deacetylase, putative 0.0012 0.0007 0.0359
Entamoeba histolytica calpain large subunit domain III containing protein 0.0016 0.0017 0.0202
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0012 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0086 0.1105
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.001 0.0002 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.017 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.017 0.2194
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0052 0.0162
Entamoeba histolytica hypothetical protein 0.0035 0.0068 0.0864
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0068 0.0212
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0039 0.2257
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0504 0.1291 1
Echinococcus granulosus histone deacetylase 6 0.0012 0.0007 0.0019
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.0039 0.0039
Schistosoma mansoni histone deacetylase 4 5 0.0012 0.0007 0.0019
Entamoeba histolytica hypothetical protein 0.0014 0.0013 0.0148
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0009 0.0098
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0034 0.0078
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0156 0.0489
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.004 0.2311
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0041 0.0219
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0366 0.2761
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.017 0.1231
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.0158
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0054 0.3133
Echinococcus multilocularis ets variant gene 4 0.001 0.0004 0.0006
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0009 0.0161
Echinococcus granulosus integrin alpha ps 0.0032 0.006 0.0187
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0126 0.1608
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0226 0.0565 0.0564
Loa Loa (eye worm) hypothetical protein 0.0074 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.0041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.017 0.0533
Entamoeba histolytica aminopeptidase, putative 0.0024 0.0039 0.0486
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0504 0.1291 0.129
Brugia malayi histone deacetylase 3 (HD3) 0.0041 0.0084 0.0083
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0074 0.017 0.017
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.0372 0.0882
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0007 0.0335
Loa Loa (eye worm) hypothetical protein 0.0041 0.0084 0.0084
Toxoplasma gondii exonuclease III APE 0.0057 0.0126 0.0968
Leishmania major hypothetical protein, conserved 0.0012 0.0007 0.0335
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.0121
Brugia malayi calpain family protein 1 0.0059 0.0131 0.013
Echinococcus multilocularis ephrin type A receptor 4 A 0.0065 0.0145 0.0343
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0063
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.017 0.017
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0035 0.2001
Plasmodium falciparum histone deacetylase, putative 0.0012 0.0007 0.0035
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0039 0.0038
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0062 0.0138 0.0432
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0039 0.0495
Echinococcus granulosus aminopeptidase N 0.0024 0.0039 0.012
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0009 0.0059
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0005 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0009 0.0098
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0039 0.0495
Onchocerca volvulus 0.0012 0.0009 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0052 0.0162
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0025 1
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0007 0.0335
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0004 0.0004
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0007 0.0006
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0002 0.0002
Schistosoma mansoni chromobox protein 0.0075 0.0172 0.054
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0039 0.0038
Schistosoma mansoni calpain-7 (C02 family) 0.0028 0.005 0.0155
Onchocerca volvulus 0.0231 0.0579 0.3199
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0009 0.0024
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.017 0.1276
Echinococcus multilocularis histone deacetylase 0.0012 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0007 0.0007
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0012 0.0007 0.0335
Echinococcus granulosus calpain A 0.0022 0.0035 0.0107
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0039 0.2257
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0004 0.0006
Brugia malayi histone deacetylase 11 0.0012 0.0007 0.0006
Leishmania major tyrosyl-tRNA synthetase, putative 0.0018 0.0024 0.135
Schistosoma mansoni hypothetical protein 0.0096 0.0227 0.0711
Brugia malayi Ets-domain containing protein 0.0072 0.0164 0.0163
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0232 0.0582 0.0582
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0007 0.0007
Onchocerca volvulus Phospholipase A2 homolog 0.0281 0.071 0.3923
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0068 0.0161
Schistosoma mansoni chromobox protein 0.0075 0.0172 0.054
Brugia malayi hypothetical protein 0.0016 0.0018 0.0017
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.004 0.2311
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0007 0.0007
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0007 0.0073
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0093 0.1188
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0294 0.0294
Trypanosoma brucei histone deacetylase 4 0.0012 0.0007 0.0359
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0035 0.2001
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0009
Brugia malayi chromobox protein homolog 3 0.0042 0.0086 0.0085
Loa Loa (eye worm) histone deacetylase 1 0.0041 0.0084 0.0084
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0013 0.0009 0.049
Echinococcus granulosus Solute carrier family 22 5 0.1083 0.28 0.8805
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0002 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0009 0.0098
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.005 0.0153
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0035 0.2001
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0009 0.0009
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.0372 0.0371
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0138 0.0432
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0035 0.2001
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0039 0.2257
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0009 0.0018
Plasmodium falciparum tyrosine--tRNA ligase 0.0018 0.0024 0.1444
Trypanosoma cruzi kinesin, putative 0.0016 0.0017 0.0965
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0114 0.6645
Trichomonas vaginalis esterase, putative 0.0074 0.017 0.2194
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0114 0.0354
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.0039 0.2257
Echinococcus granulosus histone deacetylase 6 0.0012 0.0007 0.0019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0226 0.0565 0.0565
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0156 0.9177
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.017 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0002 0.0002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0007 0.0006
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0002 0.0002
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0007 0.0013
Echinococcus multilocularis histone deacetylase 7 0.0012 0.0007 0.0014
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0019 0.1039
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0098
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Leishmania major hypothetical protein, conserved 0.0012 0.0007 0.0335
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0156 0.037
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.0367 0.0367
Echinococcus multilocularis histone deacetylase 3 0.0041 0.0084 0.0197
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0039 0.012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0039
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0052 0.0122
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0039 0.0497
Trichomonas vaginalis hypothetical protein 0.0012 0.0009 0.0098
Echinococcus multilocularis histone deacetylase 6 0.0012 0.0007 0.0014
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0039 0.2257
Loa Loa (eye worm) hypothetical protein 0.0074 0.017 0.017
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0007 0.0335
Toxoplasma gondii tRNA synthetases class I family protein 0.0018 0.0024 0.0177
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0039 0.2257
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0226 0.0565 0.1342
Onchocerca volvulus 0.0028 0.005 0.0272
Leishmania major histone deacetylase, putative 0.0041 0.0084 0.4878
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0009 0.0024
Echinococcus multilocularis endothelin converting enzyme 1 0.0504 0.1291 0.3069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0774 1
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.001 0.0002 0.001
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0114 0.0268
Onchocerca volvulus 0.0318 0.0807 0.4458
Onchocerca volvulus 0.0055 0.0119 0.0654
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0106 0.025
Loa Loa (eye worm) hypothetical protein 0.0064 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0408 0.104 0.104
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0156 0.9177
Echinococcus multilocularis geminin 0.1229 0.318 0.7563
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0114 0.6645
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0012 0.0007 0.0335
Leishmania major cytochrome p450-like protein 0.0016 0.0019 0.1039
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.0579 0.0579
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.004 0.0304
Loa Loa (eye worm) acetyltransferase 0.0152 0.0372 0.0372
Loa Loa (eye worm) G protein alpha subunit 3 0.001 0.0002 0.0002
Echinococcus multilocularis musashi 0.0028 0.005 0.0117
Plasmodium vivax calpain, putative 0.0022 0.0035 0.2001
Brugia malayi Ets-domain containing protein 0.001 0.0004 0.0003
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0035 0.2001
Schistosoma mansoni cript-related 0.0012 0.0007 0.0018
Trypanosoma cruzi Aminopeptidase M1, putative 0.0024 0.0039 0.2257
Loa Loa (eye worm) aminopeptidase N 0.0024 0.0039 0.0039
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0039 0.012
Loa Loa (eye worm) hypothetical protein 0.0044 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0012 0.0009 0.0024
Plasmodium vivax histone deacetylase 1, putative 0.0041 0.0084 0.4878
Brugia malayi RNA binding protein 0.0065 0.0146 0.0145
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0052
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.0121
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0093 0.1188
Echinococcus multilocularis tyrosyl tRNA synthetase 0.0032 0.006 0.0142
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0126 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0084 0.4878
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.017 0.1276
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0012 0.0007 0.0335
Mycobacterium ulcerans lipase LipD 0.0074 0.017 0.1231
Giardia lamblia Tyrosyl-tRNA synthetase 0.0018 0.0024 0.0296
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0009 0.0161
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0106 0.033
Trypanosoma brucei antigen, putative 0.0022 0.0035 0.2001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0009 0.0098
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0084 0.107
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0007 0.0073
Loa Loa (eye worm) hypothetical protein 0.0318 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.001 0.0002 0.0002
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0004 0.0006
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0504 0.1291 0.4058
Echinococcus multilocularis aminoacyl tRNA synthase complex interacting 0.0014 0.0013 0.0029
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0126 0.0393
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0009 0.0059
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0172 0.222
Entamoeba histolytica hypothetical protein 0.0012 0.0009 0.0088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0022 0.0121
Giardia lamblia Inositol 5-phosphatase 4 0.0012 0.0007 0.0073
Loa Loa (eye worm) peptidase family M1 containing protein 0.0024 0.0039 0.0039
Echinococcus multilocularis integrin alpha ps 0.0067 0.0152 0.0359
Loa Loa (eye worm) hypothetical protein 0.0113 0.0272 0.0272
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0002 0.0002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0156 0.9177
Trypanosoma brucei tyrosyl-tRNA synthetase, putative 0.0018 0.0024 0.135
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.004 0.281
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0063
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0034 0.0103
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0002 0.0002
Trichomonas vaginalis ran, putative 0.0022 0.0034 0.0422
Echinococcus multilocularis histone deacetylase 6 0.0012 0.0007 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0114 0.1458
Mycobacterium leprae conserved hypothetical protein 0.0074 0.017 0.1035
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0009 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0013 0.0158
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0004 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0041 0.237
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Brugia malayi Phospholipase A2 family protein 0.0703 0.1808 0.1807
Echinococcus multilocularis histone deacetylase 1 0.0041 0.0084 0.0197
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0084 0.107
Echinococcus granulosus chromobox protein 1 0.0075 0.0172 0.054
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.0041
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0044
Echinococcus multilocularis calpain 0.0022 0.0035 0.0081
Brugia malayi CHD4 protein 0.0012 0.0009 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0052 0.0122
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.005 0.0049
Leishmania major hypothetical protein, conserved 0.0024 0.004 0.2311
Schistosoma mansoni hypothetical protein 0.005 0.0106 0.033
Plasmodium falciparum histone deacetylase 1 0.0041 0.0084 0.6461
Entamoeba histolytica hypothetical protein 0.0035 0.0068 0.0864
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0146 0.0456
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0002 0.0002
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0007 0.0073
Echinococcus granulosus calpain 5 0.0022 0.0035 0.0107
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0007 0.0013
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0002 0.0001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0126 0.7368
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.001 0.0002 0.001
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0004 0.0004
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0013
Onchocerca volvulus 0.0055 0.0119 0.0654
Echinococcus granulosus tar DNA binding protein 0.0065 0.0146 0.0456
Brugia malayi Histone deacetylase 1 0.0041 0.0084 0.0083
Entamoeba histolytica hypothetical protein 0.0014 0.0013 0.0148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0226 0.0565 0.1774
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0041 0.0219
Echinococcus granulosus histone deacetylase 7 0.0012 0.0007 0.0019
Echinococcus granulosus Chromo domain 0.0012 0.0009 0.0024
Leishmania major hypothetical protein, conserved 0.0019 0.0026 0.1475
Toxoplasma gondii ABC1 family protein 0.0074 0.017 0.1314
Loa Loa (eye worm) hypothetical protein 0.0281 0.071 0.071
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0002 0.001
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0055 0.0119 0.0372
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.017 0.1276
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0009 0.0098
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0002 0.0002
Toxoplasma gondii aminopeptidase N protein 0.0024 0.0039 0.0297
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0004 0.0009
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.017 0.1276
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.0774 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0095 0.0095
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0041 0.237
Schistosoma mansoni importin beta-1 0.003 0.0054 0.0167
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.001 0.0002 0.0002
Schistosoma mansoni methionyl-tRNA synthetase 0.0014 0.0013 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0041 0.004
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0044
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0007 0.0013
Leishmania major endonuclease/exonuclease protein-like protein 0.0012 0.0007 0.0335
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0415 0.1057 0.1057
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0126 0.1616
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0114 0.0354
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0012 0.0007 0.0063
Loa Loa (eye worm) histone deacetylase 0.0012 0.0007 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0041 0.0219
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0034 0.1924
Brugia malayi Heterochromatin protein 1 0.0075 0.0172 0.0172
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0007 0.0335
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0009 0.0098
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0041 0.051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0226 0.0565 0.1774
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0186 0.0461 0.1447
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0007 0.0063
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0009 0.0008
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.001 0.0002 0.0001
Trypanosoma cruzi tyrosyl or methionyl-tRNA synthetase, putative 0.0014 0.0013 0.072
Brugia malayi beta-lactamase family protein 0.0074 0.017 0.017
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0039 0.2257
Schistosoma mansoni chromobox protein 0.0012 0.0009 0.0024
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0126 0.1616
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni lamin 0.0028 0.005 0.0154
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0126 0.0126
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0039 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0054 0.069
Mycobacterium ulcerans hypothetical protein 0.0025 0.0041 0.0219
Schistosoma mansoni ap endonuclease 0.0057 0.0126 0.0393
Loa Loa (eye worm) histone deacetylase 3 0.0041 0.0084 0.0084
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0025 0.0091
Onchocerca volvulus 0.0028 0.005 0.0272
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.001 0.0002 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0074 0.017 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0039 0.012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0086 0.0473
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0156 0.0489
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0126 0.1616
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0012 0.0007 0.0335
Echinococcus multilocularis lamin dm0 0.0028 0.005 0.0117
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.017 0.1276
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0063
Echinococcus granulosus synaptojanin 1 0.0012 0.0007 0.0018
Trypanosoma cruzi histone deacetylase, putative 0.0012 0.0007 0.0359
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0024 0.0039 0.012
Schistosoma mansoni hypothetical protein 0.005 0.0106 0.033
Entamoeba histolytica Ran family GTPase 0.0022 0.0034 0.0412
Schistosoma mansoni ets-related 0.001 0.0004 0.0009
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0007 0.0013
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0009 0.0088
Onchocerca volvulus 0.0037 0.0073 0.0398
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0004 0.0009
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0004 0.0009
Echinococcus granulosus histone deacetylase 8 0.0012 0.0007 0.0019
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0138 0.0432
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0114 0.0114
Echinococcus granulosus GPCR family 2 0.005 0.0106 0.033
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0039 0.0204
Brugia malayi N-terminal motif family protein 0.0179 0.0444 0.0443
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0106
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0002 0.0002
Brugia malayi ephrin receptor 1 precursor 0.0031 0.0057 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0054 0.069
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0007 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0774 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0086 0.0086
Echinococcus multilocularis calpain 5 0.0022 0.0035 0.0081
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0007 0.0044
Schistosoma mansoni ap endonuclease 0.0057 0.0126 0.0393
Treponema pallidum fructose-bisphosphate aldolase 0.0306 0.0774 1
Loa Loa (eye worm) hypothetical protein 0.0408 0.104 0.104
Schistosoma mansoni endothelin-converting enzyme-related 0.009 0.021 0.0659
Loa Loa (eye worm) hypothetical protein 0.003 0.0054 0.0054
Plasmodium falciparum tRNA import protein tRIP 0.0014 0.0013 0.0548
Echinococcus multilocularis histone deacetylase 6 0.0012 0.0007 0.0014
Echinococcus multilocularis expressed protein 0.001 0.0002 0.0002
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0039 0.0091
Brugia malayi MAP kinase sur-1 0.0053 0.0114 0.0113
Leishmania major hypothetical protein, conserved 0.0012 0.0007 0.0335
Leishmania major pantothenate kinase subunit, putative 0.0013 0.0009 0.049
Brugia malayi Pre-SET motif family protein 0.0203 0.0506 0.0505
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0004 0.0004
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0146 0.0145
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0096 0.0227 0.0711
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0034 0.2261
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.0805 0.0805
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.0361 0.1132
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0007 0.0073
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.009 0.021 0.0659
Onchocerca volvulus Histone deacetylase 10 homolog 0.0012 0.0007 0.0034
Leishmania major histone deacetylase, putative 0.0041 0.0084 0.4878
Schistosoma mansoni calpain-7 (C02 family) 0.0028 0.005 0.0155
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.009 0.021 0.0659
Plasmodium vivax exodeoxyribonuclease III, putative 0.0012 0.0007 0.0335
Plasmodium falciparum histone deacetylase 2 0.0012 0.0007 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0013 0.072
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0002 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0052 0.0162
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0012 0.0007 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0009 0.0448
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0156 0.0156
Schistosoma mansoni integrin alpha 0.015 0.0367 0.1153
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0415 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0007 0.0073
Echinococcus granulosus chromobox protein 2 0.0012 0.0009 0.0024
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.017 0.1276
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0035 0.2001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0041 0.0219
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0114 0.6645
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0026 0.1475
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) calpain 5 0.0016 0.0017 0.0017
Brugia malayi SET domain containing protein 0.0013 0.0011 0.001
Plasmodium vivax methionine-tRNA ligase, putative 0.0014 0.0013 0.072
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0084 0.107
Echinococcus multilocularis synaptojanin 1 0.0012 0.0007 0.0013
Plasmodium falciparum importin beta, putative 0.003 0.0054 0.3979
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0093 0.0289
Schistosoma mansoni hypothetical protein 0.0032 0.006 0.0187
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0019 0.0019
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0009 0.0024
Echinococcus granulosus importin subunit beta 1 0.003 0.0054 0.0167
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0007 0.0018
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.0366 0.2599
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0098
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0019 0.1039
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0007 0.0007
Brugia malayi CCR4 0.0012 0.0007 0.0006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0126 0.7368
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.005
Schistosoma mansoni integrin alpha-ps 0.0067 0.0152 0.0474
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.001 0.0002 0.0001
Schistosoma mansoni histone deacetylase 0.0041 0.0084 0.026
Echinococcus granulosus protein C ets 2 0.001 0.0004 0.0009
Toxoplasma gondii methionyl-tRNA synthetase 0.0014 0.0013 0.0095
Onchocerca volvulus 0.001 0.0002 0.0004
Echinococcus granulosus calpain 0.0022 0.0035 0.0107
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0106 0.033
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0007 0.0335
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.017 1
Trypanosoma cruzi histone deacetylase, putative 0.0012 0.0007 0.0359
Mycobacterium tuberculosis Conserved protein 0.0074 0.017 0.1276
Entamoeba histolytica hypothetical protein 0.0024 0.0039 0.0488
Leishmania major RNA-editing complex protein MP100, putative 0.0012 0.0007 0.0335
Loa Loa (eye worm) hypothetical protein 0.0408 0.104 0.104
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0028 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0096 0.0227 0.0711
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0052 0.0162
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0055 0.0119 0.0372
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0035 0.2001
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.017 0.2194
Giardia lamblia Histone deacetylase 0.0041 0.0084 0.107
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0084 0.107
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0022 0.0035 0.2001
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0035 0.2001
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0164 0.0388

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 11 uM In vitro inhibitory activity against TNF-alpha production in mouse macrophages stimulated with LPS ChEMBL. No reference
IC50 (functional) = 11 uM In vitro inhibitory activity against TNF-alpha production in mouse macrophages stimulated with LPS ChEMBL. No reference
Survival rate (functional) = 0 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 0 mg/kg on day 7 ChEMBL. No reference
Survival rate (functional) = 0 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 0 mg/kg on day 7 ChEMBL. No reference
Survival rate (functional) = 8 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 50 mg/kg on day 7 ChEMBL. No reference
Survival rate (functional) = 8 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 100 mg/kg on day 7 ChEMBL. No reference
Survival rate (functional) = 8 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 50 mg/kg on day 7 ChEMBL. No reference
Survival rate (functional) = 8 number of mice Protection against LPS-induced death of D-galactosamine-sensitized mice (10 in number) at specified dose of 100 mg/kg on day 7 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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