Detailed information for compound 281581

Basic information

Technical information
  • TDR Targets ID: 281581
  • Name: (2R,4S)-N-[4-(diethoxyphosphorylmethyl)phenyl ]-7,8-dimethoxy-4-methyl-5-oxo-1,2-dihydro-3- benzothiepine-2-carboxamide
  • MW: 521.563 | Formula: C25H32NO7PS
  • H donors: 1 H acceptors: 3 LogP: 3.47 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOP(=O)(Cc1ccc(cc1)NC(=O)[C@@H]1S[C@@H](C)C(=O)c2c(C1)cc(OC)c(c2)OC)OCC
  • InChi: 1S/C25H32NO7PS/c1-6-32-34(29,33-7-2)15-17-8-10-19(11-9-17)26-25(28)23-13-18-12-21(30-4)22(31-5)14-20(18)24(27)16(3)35-23/h8-12,14,16,23H,6-7,13,15H2,1-5H3,(H,26,28)/t16-,23+/m0/s1
  • InChiKey: ZTNLBHLNRRUNOU-QMHKHESXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,4S)-N-[4-(diethoxyphosphorylmethyl)phenyl]-5-keto-7,8-dimethoxy-4-methyl-1,2-dihydro-3-benzothiepine-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0071 0.0123 0.0498
Echinococcus multilocularis peregrin 0.0071 0.0123 0.0172
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0004 0.0007
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0004 0.0017
Brugia malayi BRM protein 0.0071 0.0123 0.0169
Trypanosoma brucei Bromodomain, putative 0.0071 0.0123 0.045
Schistosoma mansoni hypothetical protein 0.0105 0.0197 0.0802
Trichomonas vaginalis glucosylceramidase, putative 0.0231 0.0469 0.1906
Trichomonas vaginalis bromodomain-containing protein, putative 0.0224 0.0454 0.1845
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Schistosoma mansoni synaptojanin 0.0015 0.0002 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0066 0.0264
Brugia malayi RE15519p 0.0016 0.0004 0.0006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Loa Loa (eye worm) bromodomain containing protein 0.0175 0.0349 0.1424
Echinococcus multilocularis bromodomain containing protein 8 0.0071 0.0123 0.0172
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0071 0.0123 0.0494
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0015 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0084 0.0151 0.0617
Echinococcus granulosus nmda type glutamate receptor 0.0142 0.0276 0.0535
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Plasmodium vivax bromodomain protein, putative 0.0071 0.0123 0.045
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0004 0.0005
Trypanosoma cruzi lanosterol synthase, putative 0.0156 0.0309 0.1136
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0048 0.0075 0.0144
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Trichomonas vaginalis bromodomain containing protein, putative 0.0224 0.0454 0.1845
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0048 0.0075 0.0105
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0004 0.0005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Schistosoma mansoni glutamate receptor kainate 0.004 0.0056 0.0226
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Trichomonas vaginalis bromodomain-containing protein, putative 0.0328 0.068 0.2769
Echinococcus multilocularis cpg binding protein 0.0029 0.0034 0.0046
Schistosoma mansoni sex comb on midleg homolog 0.0043 0.0062 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0071 0.0123 0.0494
Echinococcus multilocularis deoxyribonuclease 1 2 0.0015 0.0002 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0007
Onchocerca volvulus Brd8 homolog 0.0071 0.0123 0.0121
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Schistosoma mansoni hypothetical protein 0.0655 0.1386 0.5652
Echinococcus multilocularis NMDA receptor 0.004 0.0056 0.0078
Schistosoma mansoni histamine h1 receptor 0.0016 0.0004 0.0014
Echinococcus multilocularis neuropeptide s receptor 0.0016 0.0004 0.0005
Brugia malayi Guanylyl cyclase protein 23 0.002 0.0014 0.002
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0235 0.0479 0.1952
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0314 0.0648 0.1256
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1267 0.271 1
Toxoplasma gondii bromodomain-containing protein 0.0071 0.0123 0.045
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Giardia lamblia Prenyltransferase 0.0235 0.0479 0.1764
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0072 0.0126 0.0462
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.0196 0.0721
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0108 0.0205 0.0753
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.1148 0.2452 1
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0004 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Echinococcus granulosus traf and tnf receptor associated protein 0.0015 0.0002 0.0002
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0004 0.0014
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Echinococcus granulosus lamin dm0 0.0026 0.0026 0.0048
Loa Loa (eye worm) MBCTL1 0.0048 0.0075 0.0306
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0004 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Loa Loa (eye worm) glutamate receptor 2 0.004 0.0056 0.0229
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Echinococcus granulosus metabotropic glutamate receptor 5 0.002 0.0014 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Brugia malayi hypothetical protein 0.0016 0.0004 0.0006
Trichomonas vaginalis hypothetical protein 0.0071 0.0123 0.0494
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0014 0.0059
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0004 0.0014
Echinococcus granulosus survival motor neuron protein 1 0.0759 0.1612 0.3124
Schistosoma mansoni phd finger protein 0.0071 0.0123 0.0498
Echinococcus multilocularis musashi 0.0026 0.0026 0.0035
Echinococcus granulosus CREB binding protein 0.0064 0.011 0.0211
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.006 0.01 0.0193
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0007
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0004 0.0005
Brugia malayi hypothetical protein 0.0084 0.0151 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0004 0.0005
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0102 0.0191 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.0196 0.0793
Trypanosoma brucei Bromodomain, putative 0.0071 0.0123 0.045
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0004 0.0005
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0219 0.0893
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0014
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.004 0.0056 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0014
Schistosoma mansoni carbon catabolite repressor protein 0.0015 0.0002 0.0004
Brugia malayi neuropeptide F receptor 0.0016 0.0004 0.0006
Trypanosoma cruzi protein farnesyltransferase, putative 0.0235 0.0479 0.1767
Brugia malayi G-protein coupled receptor 0.0016 0.0004 0.0006
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0002 0.0003
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0004 0.0017
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0014 0.0055
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0123 0.045
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0002 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0196 0.0793
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0003
Brugia malayi Bromodomain containing protein 0.0072 0.0126 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0014
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.045 0.0943 0.3841
Echinococcus multilocularis metabotropic glutamate receptor 2 0.002 0.0014 0.0019
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0072 0.0126 0.4066
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0056 0.0226
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0314 0.0648 0.239
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Entamoeba histolytica hypothetical protein 0.002 0.0014 0.0052
Brugia malayi Bromodomain containing protein 0.0071 0.0123 0.0169
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0071 0.0123 0.0172
Loa Loa (eye worm) hypothetical protein 0.0071 0.0123 0.0501
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Trypanosoma cruzi bromodomain factor 2 protein 0.0071 0.0123 0.045
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0004 0.0014
Plasmodium falciparum bromodomain protein 2, putative 0.0071 0.0123 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Schistosoma mansoni polybromo-1 0.0071 0.0123 0.0498
Trypanosoma cruzi Bromodomain factor 1 0.0071 0.0123 0.045
Leishmania major DNA-binding protein, putative,predicted bromodomain protein 0.0071 0.0123 0.045
Onchocerca volvulus 0.0016 0.0004 0.0003
Brugia malayi ORL1-like opioid receptor 0.0016 0.0004 0.0006
Onchocerca volvulus 0.0026 0.0026 0.0024
Entamoeba histolytica bromodomain-containing protein 0.0071 0.0123 0.0494
Echinococcus granulosus cpg binding protein 0.0029 0.0034 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0072 0.0126 0.0459
Echinococcus granulosus glutamate receptor ionotropic kainate 0.004 0.0056 0.0107
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0071 0.0123 0.0494
Loa Loa (eye worm) hypothetical protein 0.0034 0.0044 0.0178
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0003
Schistosoma mansoni cpg binding protein 0.0029 0.0034 0.0133
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0004 0.0014
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.0196 0.0194
Trypanosoma cruzi Bromodomain, putative 0.0071 0.0123 0.045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0066 0.0264
Schistosoma mansoni neuropeptide receptor 0.0016 0.0004 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0003
Schistosoma mansoni cpg binding protein 0.0029 0.0034 0.0133
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0102 0.0191 1
Echinococcus granulosus neuropeptide receptor 0.0016 0.0004 0.0007
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0043 0.0062 0.0251
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0004 0.0005
Onchocerca volvulus 0.0016 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0105 0.0197 0.0381
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Onchocerca volvulus 0.0016 0.0004 0.0003
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0004 0.0017
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0004 0.0017
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Onchocerca volvulus 0.0043 0.0062 0.0061
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.1148 0.2452 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0026 0.0035
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0002 0.0003
Schistosoma mansoni cpg binding protein 0.0028 0.003 0.012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0151 0.0297 0.1206
Echinococcus multilocularis nmda type glutamate receptor 0.002 0.0014 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0151 0.0297 0.1206
Loa Loa (eye worm) hypothetical protein 0.0043 0.0062 0.0254
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Echinococcus multilocularis lamin 0.0026 0.0026 0.0035
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0003
Echinococcus granulosus g protein coupled receptor 0.0016 0.0004 0.0007
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0004 0.0005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0014
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0014
Brugia malayi Bromodomain containing protein 0.0071 0.0123 0.0169
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0004 0.0007
Brugia malayi GnHR receptor homolog 0.2834 0.6099 0.84
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0007
Onchocerca volvulus 0.0305 0.0631 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0004 0.0007
Echinococcus granulosus serotonin receptor 0.0016 0.0004 0.0007
Onchocerca volvulus 0.002 0.0014 0.0013
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.0001 0.0003
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0002
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.1148 0.2452 0.4754
Schistosoma mansoni CREB-binding protein 2 0.0456 0.0957 0.3902
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0314 0.0648 0.239
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0056 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0004 0.0014
Trichomonas vaginalis bromodomain containing protein, putative 0.0071 0.0123 0.0494
Toxoplasma gondii hypothetical protein 0.0071 0.0123 0.045
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0059
Onchocerca volvulus 0.0016 0.0004 0.0003
Schistosoma mansoni opsin-like receptor 0.0016 0.0004 0.0014
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0004 0.0017
Loa Loa (eye worm) glutamate receptor 0.002 0.0014 0.0059
Brugia malayi mbt repeat family protein 0.0043 0.0062 0.0086
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0014 0.002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0105 0.0197 0.0277
Trichomonas vaginalis glucosylceramidase, putative 0.0151 0.0297 0.1206
Loa Loa (eye worm) hypothetical protein 0.0184 0.0369 0.1505
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0126 0.0177
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0072 0.0126 0.0462
Brugia malayi polybromodomain protein 0.0071 0.0123 0.0169
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0071 0.0123 0.045
Brugia malayi AKH receptor 0.0016 0.0004 0.0006
Onchocerca volvulus 0.0016 0.0004 0.0003
Plasmodium vivax bromodomain protein, putative 0.0071 0.0123 0.045
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0235 0.0479 0.1767
Echinococcus multilocularis serotonin receptor 0.0016 0.0004 0.0005
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Brugia malayi intermediate filament protein 0.0026 0.0026 0.0035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0004 0.0005
Onchocerca volvulus 0.0028 0.003 0.0028
Schistosoma mansoni hypothetical protein 0.0155 0.0305 0.1241
Schistosoma mansoni amine GPCR 0.0016 0.0004 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0014
Plasmodium falciparum bromodomain protein, putative 0.0071 0.0123 0.045
Echinococcus multilocularis global transcription activator snf2l2 0.0071 0.0123 0.0172
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0072 0.0126 0.0514
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0314 0.0648 0.239
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0456 0.0957 0.3902
Schistosoma mansoni hypothetical protein 0.0068 0.0116 0.0472
Plasmodium vivax SET domain containing protein 0.0071 0.0124 0.0455
Echinococcus granulosus histone acetyltransferase MYST2 0.0048 0.0075 0.0144
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0235 0.0479 0.1949
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Entamoeba histolytica bromodomain-containing protein 0.0175 0.0349 0.1418
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0014
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0004 0.0007
Echinococcus granulosus GPCR family 2 0.0105 0.0197 0.0381
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0015 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0235 0.0479 0.1949
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Echinococcus multilocularis glutamate receptor 2 0.006 0.01 0.014
Loa Loa (eye worm) hypothetical protein 0.0072 0.0126 0.0515
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0205 0.0753
Schistosoma mansoni hypothetical protein 0.0071 0.0123 0.0498
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0235 0.0479 0.1949
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0002 0.0003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0004 0.0006
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0072 0.0126 0.0243
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0016 0.0004 0.0017
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Giardia lamblia Kinase, PLK 0.0104 0.0196 0.0718
Mycobacterium tuberculosis Probable exported protein 0.0015 0.0002 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0066 0.0126
Plasmodium vivax prenyltransferase alpha subunit, putative 0.1148 0.2452 0.9049
Schistosoma mansoni bromodomain containing protein 0.0072 0.0126 0.0512
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0015 0.0002 0.0003
Schistosoma mansoni helicase 0.0071 0.0123 0.0498
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0004 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Echinococcus multilocularis neutral sphingomyelinase 0.0015 0.0002 0.0001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.006 0.01 0.014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0072 0.0126 0.0462
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0004 0.0005
Echinococcus multilocularis bromodomain containing protein 7 0.0749 0.159 0.2237
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0004 0.0007
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0004 0.0006
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0071 0.0123 0.045
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0004 0.0014
Schistosoma mansoni glutamate receptor NMDA 0.004 0.0056 0.0226
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0071 0.0123 0.0172
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0002 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0105 0.0197 0.0272
Loa Loa (eye worm) hypothetical protein 0.0072 0.0126 0.0515
Trypanosoma brucei polo-like protein kinase 0.0104 0.0196 0.0721
Plasmodium vivax bromodomain protein, putative 0.0071 0.0123 0.045
Plasmodium falciparum DNase I-like protein, putative 0.0015 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0004 0.0006
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0235 0.0479 0.1949
Toxoplasma gondii bromodomain-containing protein 0.0071 0.0123 0.045
Onchocerca volvulus 0.0175 0.0349 0.0347
Echinococcus granulosus SAM and MBT domain containing protein 0.0043 0.0062 0.0119
Brugia malayi hypothetical protein 0.0016 0.0004 0.0006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0105
Echinococcus multilocularis synaptojanin 1 0.0015 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Brugia malayi CXXC zinc finger family protein 0.0028 0.003 0.0041
Echinococcus granulosus glutamate receptor 2 0.002 0.0014 0.0026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0004 0.0017
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0066 0.0091
Leishmania major telomerase reverse transcriptase, putative 0.1267 0.271 1
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0004 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0105 0.0197 0.0805
Trichomonas vaginalis glucosylceramidase, putative 0.0159 0.0315 0.1278
Trichomonas vaginalis glucosylceramidase, putative 0.0151 0.0297 0.1206
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0071 0.0123 0.0237
Brugia malayi Metabotropic glutamate receptor precursor. 0.002 0.0014 0.002
Brugia malayi hypothetical protein 0.0105 0.0197 0.0271
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0332 0.0688 0.2805
Trichomonas vaginalis bromodomain containing protein, putative 0.0071 0.0123 0.0494
Trichomonas vaginalis bromodomain-containing protein, putative 0.0224 0.0454 0.1845
Echinococcus multilocularis tyrosine kinase 0.002 0.0014 0.0019
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0059
Brugia malayi hypothetical protein 0.0016 0.0004 0.0006
Echinococcus multilocularis metabotropic glutamate receptor 5 0.002 0.0014 0.0019
Onchocerca volvulus 0.0071 0.0123 0.0121
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0004 0.0007
Leishmania major farnesyltransferase beta subunit 0.0235 0.0479 0.1767
Trichomonas vaginalis ap endonuclease, putative 0.0072 0.0126 0.0507
Schistosoma mansoni hypothetical protein 0.0105 0.0197 0.0802
Plasmodium vivax telomerase reverse transcriptase, putative 0.1267 0.271 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0231 0.0469 0.0646
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0004 0.0007
Echinococcus multilocularis atrial natriuretic peptide receptor 0.002 0.0014 0.0019
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0071 0.0123 0.045
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Schistosoma mansoni hypothetical protein 0.004 0.0056 0.0226
Schistosoma mansoni bromodomain containing 0.0819 0.1742 0.7104
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.002 0.0014 0.0013
Toxoplasma gondii bromodomain-containing protein 0.0175 0.0349 0.1286
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Echinococcus granulosus polycomb protein SCMH1 0.0043 0.0062 0.0119
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0004 0.0005
Trypanosoma brucei telomerase reverse transcriptase 0.1267 0.271 1
Trichomonas vaginalis lymphoid specific helicase, putative 0.0071 0.0123 0.0494
Schistosoma mansoni bromodomain containing protein 0.0072 0.0126 0.0512
Echinococcus multilocularis protein kinase C binding protein 1 0.0071 0.0123 0.0172
Schistosoma mansoni tyrosine kinase 0.002 0.0014 0.0055
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.002 0.0014 0.0059
Brugia malayi Muscleblind-like protein 0.0316 0.0654 0.0901
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0101
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0004 0.0014
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0003
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0014 0.0059
Entamoeba histolytica hypothetical protein 0.0068 0.0116 0.0468
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.0196 0.0721
Loa Loa (eye worm) hypothetical protein 0.0105 0.0197 0.0805
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Trichomonas vaginalis bromodomain-containing protein, putative 0.0328 0.068 0.2769
Onchocerca volvulus Neuropeptide F receptor homolog 0.0016 0.0004 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0002 0.0003
Brugia malayi G protein-coupled receptor 0.0016 0.0004 0.0006
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.045 0.0943 0.1326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Leishmania major hypothetical protein, conserved 0.0071 0.0123 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0196 0.0797
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Brugia malayi G-protein coupled receptor 0.0016 0.0004 0.0006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0314 0.0648 0.2642
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0059
Echinococcus granulosus CREB binding protein 0.0456 0.0957 0.1855
Echinococcus multilocularis muscleblind protein 1 0.0316 0.0654 0.092
Loa Loa (eye worm) hypothetical protein 0.0328 0.068 0.2774
Echinococcus granulosus CREB binding protein 0.0306 0.0632 0.1224
Schistosoma mansoni myosin xvIII 0.0016 0.0004 0.0014
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0004 0.0005
Echinococcus granulosus g protein coupled receptor 0.0016 0.0004 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0151 0.0297 0.1206
Echinococcus multilocularis geminin 0.0655 0.1386 0.1951
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0102 0.0191 1
Entamoeba histolytica bromodomain-containing protein 0.0071 0.0123 0.0494
Echinococcus multilocularis CREB binding protein 0.0064 0.011 0.0153
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0328 0.068 0.2771
Schistosoma mansoni zinc finger protein 0.0072 0.0126 0.0512
Schistosoma mansoni eyes absent homolog 0.0084 0.0151 0.0614
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0108 0.0205 0.0753
Echinococcus multilocularis polycomb protein SCMH1 0.0043 0.0062 0.0087
Echinococcus multilocularis PH interacting protein 0.0071 0.0123 0.0172
Loa Loa (eye worm) mbt repeat family protein 0.0043 0.0062 0.0254
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0014
Schistosoma mansoni cript-related 0.0015 0.0002 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0072 0.0126 0.0507
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0002
Echinococcus granulosus somatostatin receptor 0.0016 0.0004 0.0007
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0235 0.0479 0.1955
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0004 0.0014
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.004 0.0056 0.0078
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0004 0.0006
Brugia malayi Bromodomain containing protein 0.0071 0.0123 0.0169
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.006 0.01 0.0193
Schistosoma mansoni hypothetical protein 0.0273 0.0561 0.2287
Toxoplasma gondii bromodomain-containing protein 0.0071 0.0123 0.045
Echinococcus granulosus lamin 0.0026 0.0026 0.0048
Brugia malayi Melatonin receptor type 1A 0.0016 0.0004 0.0006
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0002
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0004 0.0007
Plasmodium falciparum bromodomain protein 1 0.0071 0.0123 0.045
Echinococcus multilocularis survival motor neuron protein 1 0.0759 0.1612 0.2268
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.1148 0.2452 0.3378
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Onchocerca volvulus 0.0016 0.0004 0.0003
Plasmodium vivax geranylgeranyltransferase, putative 0.0108 0.0205 0.0753
Trichomonas vaginalis glucosylceramidase, putative 0.0231 0.0469 0.1906
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0235 0.0479 0.1767
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0007
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0003
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0015 0.0002 0.0004
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0102 0.0191 0.6166
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0016 0.0004 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Brugia malayi Glutamate receptor 2 precursor 0.004 0.0056 0.0077
Loa Loa (eye worm) hypothetical protein 0.0084 0.0151 0.0617
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0003
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0108 0.0205 0.0829
Onchocerca volvulus 0.0016 0.0004 0.0003
Plasmodium falciparum geranylgeranyltransferase, putative 0.0108 0.0205 0.0753
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0314 0.0648 0.239
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0004 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0224 0.0454 0.1845
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0004 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0196 0.0793
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0071 0.0123 0.0494
Brugia malayi larval opioid receptor 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.0196 0.08
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0175 0.0349 0.1418
Onchocerca volvulus 0.0016 0.0004 0.0003
Echinococcus granulosus Bromodomain containing protein 0.0071 0.0123 0.0237
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0004 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.0349 0.1418
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Brugia malayi Dopamine receptor protein 1 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0043 0.0062 0.0061
Echinococcus granulosus nmda type glutamate receptor 0.002 0.0014 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0196 0.0793
Echinococcus granulosus CREB binding protein 0.0064 0.011 0.0211
Schistosoma mansoni ap endonuclease 0.0072 0.0126 0.051
Schistosoma mansoni lamin 0.0026 0.0026 0.0102
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3299 0.7104 1
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Echinococcus multilocularis lamin dm0 0.0026 0.0026 0.0035
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0108 0.0205 0.0753
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Echinococcus granulosus neutral sphingomyelinase 0.0015 0.0002 0.0002
Brugia malayi Telomerase reverse transcriptase 0.3371 0.726 1
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0015 0.0002 0.0003
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0108 0.0205 0.0282
Echinococcus granulosus fmrfamide receptor 0.0016 0.0004 0.0007
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0015 0.0002 0.0003
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0004 0.0014
Brugia malayi Bromodomain containing protein 0.0071 0.0123 0.0169
Echinococcus granulosus bromodomain containing protein 8 0.0071 0.0123 0.0237
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0834 0.1774 0.7233
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0004 0.0007
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0015 0.0002 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0005
Echinococcus multilocularis CREB binding protein 0.0064 0.011 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0231 0.0469 0.1906
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0026 0.0105
Leishmania major RNA-editing complex protein MP100, putative 0.0015 0.0002 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0007
Onchocerca volvulus 0.0016 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.1148 0.2452 1
Onchocerca volvulus 0.0016 0.0004 0.0003
Echinococcus granulosus receptor type guanylyl cyclase 0.002 0.0014 0.0026
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.0365 0.0705
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.004 0.0056 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0159 0.0315 0.1278
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Trypanosoma brucei Bromodomain factor 1 0.0071 0.0123 0.045
Trypanosoma cruzi Bromodomain, putative 0.0071 0.0123 0.045
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0015 0.0002 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Schistosoma mansoni sex comb on midleg homolog 0.0043 0.0062 0.0251
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0235 0.0479 0.1949
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0314 0.0648 0.2644
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0004 0.0005
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0004 0.0007
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0004 0.0005
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0015 0.0002 0.0003
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0002 0.0001
Plasmodium falciparum telomerase reverse transcriptase 0.1267 0.271 1
Entamoeba histolytica bromodomain-containing protein 0.0071 0.0123 0.0494
Trypanosoma cruzi protein farnesyltransferase, putative 0.0235 0.0479 0.1767
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0004 0.0014
Echinococcus granulosus zinc finger protein 0.0072 0.0126 0.0243
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0005
Echinococcus granulosus peregrin 0.0071 0.0123 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.0301 0.1223
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0015 0.0002 0.0003
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0003
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0004 0.0005
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Trichomonas vaginalis bromodomain containing protein, putative 0.0071 0.0123 0.0494
Schistosoma mansoni lamin 0.0026 0.0026 0.0102
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Schistosoma mansoni opsin-like receptor 0.0016 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0007
Brugia malayi mbt repeat family protein 0.0043 0.0062 0.0086
Echinococcus multilocularis serotonin receptor 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0108 0.0205 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Onchocerca volvulus 0.0314 0.0648 0.0647
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0007
Schistosoma mansoni glutamate receptor kainate 0.004 0.0056 0.0226
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.045 0.0943 0.3845
Loa Loa (eye worm) hypothetical protein 0.0071 0.0123 0.0501
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Brugia malayi isocitrate dehydrogenase 0.0014 0.0001 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0004 0.0005
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.1148 0.2452 1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0102 0.0191 0.5
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0175 0.0349 0.1418
Brugia malayi hypothetical protein 0.0016 0.0004 0.0006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0071 0.0123 0.0237
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0004 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Brugia malayi PHD-finger family protein 0.0072 0.0126 0.0174
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.006 0.01 0.0193
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Schistosoma mansoni synaptojanin 0.0015 0.0002 0.0004
Echinococcus granulosus Bromodomain containing protein 0.2399 0.5158 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.002 0.0014 0.0026
Echinococcus granulosus PH interacting protein 0.0071 0.0123 0.0237
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0004 0.0005
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0314 0.0648 0.239
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0071 0.0123 0.0494
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0196 0.0793
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0004 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0097 0.0393
Schistosoma mansoni kinase 0.0053 0.0085 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Echinococcus multilocularis traf and tnf receptor associated protein 0.0015 0.0002 0.0001
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.0071 0.0123 0.0121
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0007
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0015 0.0002 0.0002
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0014 0.0059
Brugia malayi putative neuropeptide receptor 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Echinococcus multilocularis histone acetyltransferase MYST2 0.0048 0.0075 0.0105
Trichomonas vaginalis glucosylceramidase, putative 0.0151 0.0297 0.1206
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0004 0.0007
Entamoeba histolytica hypothetical protein 0.0068 0.0116 0.0468
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Schistosoma mansoni hypothetical protein 0.0227 0.0461 0.1877
Echinococcus granulosus atrial natriuretic peptide receptor 0.002 0.0014 0.0026
Brugia malayi TAZ zinc finger family protein 0.0456 0.0957 0.1319
Echinococcus multilocularis nmda type glutamate receptor 0.0142 0.0276 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Brugia malayi Bromodomain containing protein 0.0328 0.068 0.0937
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0004 0.0005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0235 0.0479 0.1949
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0004 0.0014
Echinococcus multilocularis polybromo 1 0.0071 0.0123 0.0172
Loa Loa (eye worm) bromodomain containing protein 0.0071 0.0123 0.0501
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0071 0.0123 0.045
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0072 0.0126 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0142 0.0276 0.0388
Echinococcus multilocularis SAM and MBT domain containing protein 0.0043 0.0062 0.0087
Entamoeba histolytica ankyrin repeat protein, putative 0.0071 0.0123 0.0494
Echinococcus granulosus hypothetical protein 0.0016 0.0004 0.0007
Echinococcus granulosus orexin receptor type 2 0.0016 0.0004 0.0007
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0002 0.0002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Schistosoma mansoni neutral sphingomyelinase 0.0015 0.0002 0.0004
Echinococcus granulosus allatostatin A receptor 0.0016 0.0004 0.0007
Leishmania major endonuclease/exonuclease protein-like protein 0.0015 0.0002 0.0003
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0004 0.0006
Brugia malayi MH2 domain containing protein 0.0115 0.0219 0.0301
Schistosoma mansoni neuropeptide receptor 0.0016 0.0004 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0231 0.0469 0.1906
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0004 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Onchocerca volvulus 0.0016 0.0004 0.0003
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0004 0.0005
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0004 0.0006
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0235 0.0479 0.0928
Toxoplasma gondii hypothetical protein 0.0834 0.1774 0.6546
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0219 0.0893
Trypanosoma brucei Bromodomain, putative 0.0071 0.0123 0.045
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0071 0.0123 0.0494
Brugia malayi Isocitrate dehydrogenase 0.0014 0.0001 0.0001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.0007
Schistosoma mansoni tyrosine kinase 0.002 0.0014 0.0055
Echinococcus multilocularis GPCR, family 2 0.0105 0.0197 0.0277
Brugia malayi hypothetical protein 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Brugia malayi hypothetical protein 0.0759 0.1612 0.222
Brugia malayi hypothetical protein 0.0016 0.0004 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Loa Loa (eye worm) hypothetical protein 0.0819 0.1742 0.7105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Echinococcus granulosus bromodomain containing 2 0.0328 0.068 0.1317
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0004 0.0005
Brugia malayi hypothetical protein 0.0016 0.0004 0.0006
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0003
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0314 0.0648 0.239
Leishmania major hypothetical protein, conserved 0.0071 0.0123 0.045
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0059
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Trypanosoma cruzi bromodomain-containing protein 3 0.0071 0.0123 0.045
Brugia malayi hypothetical protein 0.0016 0.0004 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.0072 0.0126 0.0173
Schistosoma mansoni neuropeptide receptor 0.0016 0.0004 0.0014
Schistosoma mansoni hypothetical protein 0.0394 0.0822 0.335
Brugia malayi Dopamine receptor protein 2 0.0016 0.0004 0.0006
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.002 0.0014 0.0059
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0235 0.0479 0.1767
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0108 0.0205 0.0829
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0004 0.0007
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.045 0.0943 0.1827
Onchocerca volvulus Glucosylceramidase homolog 0.0151 0.0297 0.0296
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0059
Onchocerca volvulus 0.0016 0.0004 0.0003
Schistosoma mansoni nocturnin 0.0015 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0071 0.0123 0.0501
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0007
Echinococcus granulosus global transcription activator snf2l2 0.0071 0.0123 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0059
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0071 0.0123 0.0498
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Echinococcus multilocularis 0.0071 0.0123 0.0172
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.0196 0.0275
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0068 0.0116 0.0224
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Giardia lamblia Transcription regulatory protein SNF2 0.0071 0.0123 0.0447
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0004 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0004 0.0017
Schistosoma mansoni ATP-binding cassette transporter 0.004 0.0056 0.0226
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0066 0.0126
Echinococcus multilocularis Bromodomain containing protein 0.2399 0.5158 0.726
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0196 0.0793
Brugia malayi latrophilin 2 splice variant baaae 0.0227 0.0461 0.0635
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.1148 0.2452 1
Trichomonas vaginalis hypothetical protein 0.0071 0.0123 0.0494
Schistosoma mansoni transcription initiation factor tfiid 0.0071 0.0123 0.0498
Echinococcus multilocularis zinc finger protein 0.0072 0.0126 0.0177
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0014 0.0055
Echinococcus granulosus bromodomain containing protein 7 0.0749 0.159 0.3081
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0155 0.0305 0.042
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0235 0.0479 0.1767
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0108 0.0205 0.0832
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0235 0.0479 0.1949
Schistosoma mansoni adenoreceptor 0.0016 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.1148 0.2452 0.3451
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.1148 0.2452 1
Toxoplasma gondii histone acetyltransferase TAF1/250 0.0071 0.0123 0.045
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0108 0.0205 0.0753
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0002 0.0003
Brugia malayi bromodomain containing protein 0.0071 0.0123 0.0169
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0004 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0196 0.0793
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0004 0.0014
Brugia malayi Serotonin receptor 0.0016 0.0004 0.0006
Toxoplasma gondii hypothetical protein 0.0314 0.0648 0.239
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.002 0.0014 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Schistosoma mansoni hypothetical protein 0.0749 0.159 0.6482
Schistosoma mansoni glutamate receptor kainate 0.004 0.0056 0.0226
Treponema pallidum exodeoxyribonuclease (exoA) 0.0072 0.0126 0.6578
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0004 0.0014
Schistosoma mansoni bromodomain containing protein 0.0071 0.0123 0.0498
Entamoeba histolytica hypothetical protein 0.0071 0.0123 0.0494
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Trypanosoma cruzi Bromodomain, putative 0.0071 0.0123 0.045
Schistosoma mansoni biogenic amine receptor 0.0016 0.0004 0.0014
Echinococcus multilocularis Bromodomain containing protein 0.0175 0.0349 0.049
Schistosoma mansoni myelin transcription factor 1 myt1 0.0048 0.0075 0.0303
Loa Loa (eye worm) hypothetical protein 0.0332 0.0688 0.2805
Trypanosoma cruzi Bromodomain, putative 0.0071 0.0123 0.045
Schistosoma mansoni survival motor neuron protein 0.0155 0.0305 0.1241
Giardia lamblia Hypothetical protein 0.0071 0.0123 0.0447
Echinococcus granulosus sex peptide receptor 0.0016 0.0004 0.0007
Entamoeba histolytica hypothetical protein 0.0068 0.0116 0.0468
Onchocerca volvulus 0.002 0.0014 0.0013
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0071 0.0123 0.045
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0314 0.0648 0.0893
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Schistosoma mansoni biogenic amine receptor 0.0016 0.0004 0.0014
Toxoplasma gondii exonuclease III APE 0.0072 0.0126 0.0462
Onchocerca volvulus 0.0016 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0105 0.0197 0.0802
Schistosoma mansoni hypothetical protein 0.0105 0.0197 0.0802
Brugia malayi Bromodomain containing protein 0.0328 0.068 0.0937
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Leishmania major extracellular receptor, putative 0.002 0.0014 0.005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0004 0.0005
Brugia malayi metabotropic GABA-B receptor subtype 2 0.002 0.0014 0.002
Echinococcus granulosus g protein coupled receptor 0.0016 0.0004 0.0007
Echinococcus granulosus muscleblind protein 0.0316 0.0654 0.1267
Onchocerca volvulus 0.0016 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0071 0.0123 0.0501
Brugia malayi Bromodomain containing protein 0.0071 0.0123 0.0169
Onchocerca volvulus 0.0016 0.0004 0.0003
Schistosoma mansoni amine GPCR 0.0016 0.0004 0.0014
Echinococcus multilocularis CREB binding protein 0.0064 0.011 0.0153
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0004 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0231 0.0469 0.1906
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0004 0.0014
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.006 0.01 0.014
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0004 0.0005
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.045 0.0943 0.3843
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0205 0.0753
Trypanosoma cruzi hypothetical protein, conserved 0.0314 0.0648 0.239
Giardia lamblia Telomerase catalytic subunit 0.1267 0.271 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.002 0.0014 0.0019
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0314 0.0648 0.239
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.006 0.01 0.0193
Brugia malayi acetyltransferase, GNAT family protein 0.0071 0.0123 0.0169
Toxoplasma gondii RNA-directed DNA polymerase 0.1267 0.271 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0123 0.0501
Loa Loa (eye worm) hypothetical protein 0.0759 0.1612 0.6572
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0015 0.0002 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0072 0.0126 0.0462
Toxoplasma gondii bromodomain-containing protein 0.0071 0.0123 0.045
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0108 0.0205 0.0753
Loa Loa (eye worm) hypothetical protein 0.0305 0.0631 0.2573
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0314 0.0648 0.239
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0123 0.045
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.045 0.0943 0.1299
Chlamydia trachomatis glutamine binding protein 0.0102 0.0191 0.5
Entamoeba histolytica bromodomain-containing protein 0.0175 0.0349 0.1418
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0332 0.0688 0.0947
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0314 0.0648 0.239
Echinococcus granulosus glutamate receptor 2 0.006 0.01 0.0193
Schistosoma mansoni opsin-like receptor 0.0016 0.0004 0.0014
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0004 0.0007
Entamoeba histolytica bromodomain-containing protein 0.0175 0.0349 0.1418
Brugia malayi Dopamine receptor 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0108 0.0205 0.0829
Brugia malayi sulfakinin receptor protein 0.0016 0.0004 0.0006
Schistosoma mansoni glutamate receptor NMDA 0.006 0.01 0.0406
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.1148 0.2452 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0332 0.0688 0.0947
Trichomonas vaginalis glucosylceramidase, putative 0.0231 0.0469 0.1906
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0072 0.0126 0.0462
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0004 0.0017
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Giardia lamblia Rab geranylgeranyltransferase 0.0314 0.0648 0.2388
Loa Loa (eye worm) hypothetical protein 0.0227 0.0461 0.1879
Schistosoma mansoni transcription factor LCR-F1 0.0068 0.0116 0.0472
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1267 0.271 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0066 0.009
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.0196 0.027
Loa Loa (eye worm) BRM protein 0.0071 0.0123 0.0501
Loa Loa (eye worm) hypothetical protein 0.0048 0.0075 0.0306
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0004 0.0007
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.004 0.0056 0.0107
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0004 0.0007
Loa Loa (eye worm) CBP-B 0.0336 0.0698 0.2846
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.0196 0.0721
Brugia malayi hypothetical protein 0.002 0.0014 0.002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.006 0.01 0.014
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.1148 0.2452 0.9049
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0105 0.0197 0.0381
Echinococcus multilocularis sex peptide receptor 0.0016 0.0004 0.0005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.006 0.01 0.014
Trypanosoma cruzi extracellular receptor, putative 0.002 0.0014 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0082 0.0328
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0004 0.0005
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0003
Echinococcus granulosus intermediate filament protein 0.0026 0.0026 0.0048
Schistosoma mansoni neuropeptide receptor 0.0016 0.0004 0.0014
Echinococcus multilocularis CREB binding protein 0.0333 0.069 0.0971
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.0007
Giardia lamblia Kinase, putative 0.0175 0.0349 0.1283
Giardia lamblia Rab geranylgeranyltransferase 0.0108 0.0205 0.075
Brugia malayi Glutamate receptor 1 precursor 0.004 0.0056 0.0077
Echinococcus granulosus glutamate receptor subunit protein glur 0.004 0.0056 0.0107
Onchocerca volvulus 0.0071 0.0123 0.0121
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0314 0.0648 0.2639
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.0007
Echinococcus multilocularis glutamate receptor 2 0.002 0.0014 0.0019
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0002
Echinococcus granulosus polybromo 1 0.0071 0.0123 0.0237
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Leishmania major hypothetical protein, conserved,predicted bromodomain protein 0.0071 0.0123 0.045
Trypanosoma brucei AAA ATPase, putative 0.0071 0.0123 0.045
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0003
Brugia malayi hypothetical protein 0.0305 0.0631 0.0869
Echinococcus multilocularis dnaJ subfamily B 0.0394 0.0822 0.1156
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Loa Loa (eye worm) glutamate receptor 1 0.004 0.0056 0.0229
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0015 0.0002 0.0003
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0108 0.0205 0.0753
Trypanosoma brucei RNA editing exonuclease 2 0.0015 0.0002 0.0003
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0015 0.0002 0.0003
Giardia lamblia Rab geranylgeranyltransferase 0.1148 0.2452 0.9049
Trichomonas vaginalis bromodomain containing protein, putative 0.0071 0.0123 0.0494
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0004 0.0014
Onchocerca volvulus 0.0155 0.0305 0.0303
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0105 0.0197 0.0277
Trichomonas vaginalis bromodomain-containing protein, putative 0.0224 0.0454 0.1845
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0004 0.0005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Echinococcus granulosus tyrosine kinase 0.002 0.0014 0.0026
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0004 0.0005
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.004 0.0056 0.0107
Schistosoma mansoni protein kinase 0.002 0.0014 0.0055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0066 0.0264
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0015 0.0002 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0314 0.0648 0.1256
Schistosoma mansoni amine GPCR 0.0016 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0316 0.0654 0.2668
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0003
Echinococcus multilocularis somatostatin receptor 0.0016 0.0004 0.0005
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0126 0.0243
Loa Loa (eye worm) hypothetical protein 0.0108 0.0205 0.0835
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0015 0.0002 0.0003
Onchocerca volvulus 0.0016 0.0004 0.0003
Echinococcus granulosus synaptojanin 1 0.0015 0.0002 0.0002
Echinococcus multilocularis muscleblind protein 0.0316 0.0654 0.092
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0314 0.0648 0.0912
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.0236 0.0869
Echinococcus granulosus geminin 0.0655 0.1386 0.2687
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0066 0.0091
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0015 0.0002 0.0008
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.045 0.0943 0.3843
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0026 0.0105
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0004 0.0006
Leishmania major lanosterol synthase, putative 0.0048 0.0074 0.027
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.0007
Brugia malayi CCR4 0.0015 0.0002 0.0003
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.0196 0.0379
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0003
Brugia malayi polybromodomain protein 0.0071 0.0123 0.0169
Giardia lamblia Hypothetical protein 0.0071 0.0123 0.0447
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0156 0.0309 1
Brugia malayi Bromodomain containing protein 0.0819 0.1742 0.24
Leishmania major pantothenate kinase subunit, putative 0.0015 0.0002 0.0003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0072 0.0126 0.0507
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0004 0.0007
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0235 0.0479 0.0674
Echinococcus granulosus glutamate NMDA receptor subunit 0.004 0.0056 0.0107
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0004 0.0014
Loa Loa (eye worm) acetyltransferase 0.0071 0.0123 0.0501
Leishmania major geranylgeranyltransferase, putative 0.0108 0.0205 0.0753
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0002 0.0003
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0314 0.0648 0.239
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0196 0.0793
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0105 0.0197 0.0272
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0314 0.0648 0.2639
Trypanosoma brucei bromodomain factor 2 protein, putative 0.0071 0.0123 0.045
Echinococcus multilocularis bromodomain containing 2 0.0328 0.068 0.0956
Brugia malayi Serotonin receptor 0.0016 0.0004 0.0006
Echinococcus multilocularis glutamate receptor 2 0.004 0.0056 0.0078
Onchocerca volvulus 0.0016 0.0004 0.0003
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.045 0.0943 0.3841
Entamoeba histolytica hypothetical protein 0.0068 0.0116 0.0468
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0003
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Brugia malayi follicle stimulating hormone receptor 0.0016 0.0004 0.0006
Trypanosoma cruzi lanosterol synthase, putative 0.0156 0.0309 0.1136
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0068 0.0116 0.0163
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0072 0.0126 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0082 0.0328
Loa Loa (eye worm) hypothetical protein 0.0071 0.0123 0.0501
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0127 0.0245 0.0901
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0655 0.1386 0.5652
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0235 0.0479 0.066
Brugia malayi Bromodomain containing protein 0.0071 0.0123 0.0169
Schistosoma mansoni intermediate filament proteins 0.0026 0.0026 0.0102
Brugia malayi ATPase, AAA family protein 0.0071 0.0123 0.0169
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0002 0.0003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0004 0.0005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Plasmodium vivax exodeoxyribonuclease III, putative 0.0015 0.0002 0.0003
Schistosoma mansoni amine GPCR 0.0016 0.0004 0.0014
Echinococcus granulosus protein kinase C binding protein 1 0.0071 0.0123 0.0237
Trypanosoma cruzi Bromodomain, putative 0.0071 0.0123 0.045
Echinococcus granulosus neuropeptide receptor 0.0016 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Brugia malayi hypothetical protein 0.0068 0.0116 0.016
Schistosoma mansoni biogenic amine receptor 0.0016 0.0004 0.0014
Schistosoma mansoni ap endonuclease 0.0072 0.0126 0.051
Trichomonas vaginalis bromodomain containing protein, putative 0.0175 0.0349 0.1418
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0071 0.0123 0.0237
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0004 0.0014
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.0365 0.0512
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0004 0.0005
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0231 0.0469 0.1912
Trichomonas vaginalis bromodomain-containing protein, putative 0.0071 0.0123 0.0494
Echinococcus multilocularis glutamate receptor subunit protein glur 0.004 0.0056 0.0078
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0072 0.0126 0.0462
Brugia malayi hypothetical protein 0.0016 0.0004 0.0006
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0004 0.0014
Schistosoma mansoni hypothetical protein 0.0071 0.0123 0.0498
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0004 0.0007
Trypanosoma brucei lanosterol synthase 0.0156 0.0309 0.1136
Echinococcus multilocularis neuropeptide receptor A26 0.0016 0.0004 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0059
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0004 0.0007
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0071 0.0123 0.0501
Schistosoma mansoni amine GPCR 0.0016 0.0004 0.0014
Brugia malayi hypothetical protein 0.0016 0.0004 0.0006
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.003 0.0123
Loa Loa (eye worm) hypothetical protein 0.0316 0.0654 0.2668
Trypanosoma brucei hypothetical protein, conserved 0.0314 0.0648 0.239
Onchocerca volvulus 0.0026 0.0026 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0004 0.0017
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0314 0.0648 0.0912
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0048 0.0075 0.0103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0066 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0123 0.0494
Echinococcus granulosus dnaJ subfamily B 0.0394 0.0822 0.1592
Loa Loa (eye worm) hypothetical protein 0.0108 0.0205 0.0835
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0017
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0071 0.0123 0.0494
Brugia malayi neuropeptide F receptor 0.0016 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0071 0.0123 0.0498
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0071 0.0123 0.0494
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.0014 0.002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0175 0.0349 0.1418
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0151 0.0297 0.1206

Activities

Activity type Activity value Assay description Source Reference
ALP activity (binding) = 2.3 Effect on alkaline phosphatase activity compared to control in culture of rat bone marrow stromal cells, 10E-5 M concentration ChEMBL. 10052981

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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