Detailed information for compound 29512

Basic information

Technical information
  • TDR Targets ID: 29512
  • Name: 8-(tetrazol-1-yl)-1-azabicyclo[2.2.2]octane
  • MW: 179.222 | Formula: C8H13N5
  • H donors: 0 H acceptors: 3 LogP: 0.09 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: n1nnn(c1)C1CN2CCC1CC2
  • InChi: 1S/C8H13N5/c1-3-12-4-2-7(1)8(5-12)13-6-9-10-11-13/h6-8H,1-5H2
  • InChiKey: WHVQRGDBXLRBJP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(tetrazol-1-yl)quinuclidine
  • 3-(1-tetrazolyl)quinuclidine
  • 8-(1,2,3,4-tetrazol-1-yl)-1-azabicyclo[2.2.2]octane

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Muscarinic acetylcholine receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Muscarinic acetylcholine receptor   466 aa 461 aa 23.9 %
Loa Loa (eye worm) TYRA-2 protein Muscarinic acetylcholine receptor   466 aa 497 aa 24.7 %
Onchocerca volvulus Muscarinic acetylcholine receptor   466 aa 472 aa 24.6 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Muscarinic acetylcholine receptor   466 aa 510 aa 29.8 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Muscarinic acetylcholine receptor   466 aa 493 aa 34.7 %
Echinococcus granulosus alpha 1A adrenergic receptor Muscarinic acetylcholine receptor   466 aa 459 aa 20.0 %
Echinococcus multilocularis alpha 1A adrenergic receptor Muscarinic acetylcholine receptor   466 aa 459 aa 21.1 %
Schistosoma mansoni biogenic amine receptor Muscarinic acetylcholine receptor   466 aa 484 aa 24.4 %
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) Muscarinic acetylcholine receptor   466 aa 461 aa 26.0 %
Schistosoma japonicum Octopamine receptor, putative Muscarinic acetylcholine receptor   466 aa 462 aa 26.8 %
Schistosoma japonicum Octopamine receptor 1, putative Muscarinic acetylcholine receptor   466 aa 412 aa 22.6 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Muscarinic acetylcholine receptor   466 aa 505 aa 26.9 %
Schistosoma mansoni growth hormone secretagogue receptor Muscarinic acetylcholine receptor   466 aa 462 aa 19.9 %
Echinococcus granulosus g protein coupled receptor Muscarinic acetylcholine receptor   466 aa 480 aa 18.5 %
Schistosoma mansoni biogenic amine receptor Muscarinic acetylcholine receptor   466 aa 463 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.002 0.0019 0.0161
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0047 0.0071 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0001 0.0008
Brugia malayi DKFZp564C0469 protein 0.0021 0.0022 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0849
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0013 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0002 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.002 0.0019 0.0161
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0022 0.0075
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Brugia malayi nuclear hormone receptor 0.0011 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.032 0.0598 0.1409
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.002 0.0019 0.0161
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.002 0.0019 0.0161
Echinococcus granulosus cpg binding protein 0.0034 0.0046 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0067
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0024 0.019
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0024 0.0048
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0024 0.0024
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0024 0.093
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0001 0.0002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0194 0.0356 0.0839
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0022 0.0024 0.1777
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.002 0.0019 0.0149
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0127 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0001 0.0002
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0019 0.0018 0.0059
Loa Loa (eye worm) hypothetical protein 0.0057 0.009 0.0626
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.009 0.0814
Loa Loa (eye worm) CYP4Cod1 0.003 0.0038 0.0263
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.002 0.031
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.002 0.0046
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0024 0.0205
Echinococcus multilocularis dna polymerase kappa 0.002 0.002 0.0039
Onchocerca volvulus 0.0019 0.0018 0.0017
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.002 0.0019 0.0149
Mycobacterium ulcerans DNA polymerase IV 0.002 0.002 0.0155
Brugia malayi hypothetical protein 0.0019 0.0018 0.0025
Echinococcus multilocularis 0.0044 0.0065 0.013
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.002 0.0019 0.0161
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.005 0.0068
Schistosoma mansoni ran 0.0022 0.0024 0.0052
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0044 0.0065 0.0176
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0047 0.0071 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0849
Trypanosoma cruzi UDP-galactopyranose mutase 0.0044 0.0065 0.0234
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Echinococcus granulosus dna polymerase eta 0.002 0.002 0.0046
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0023
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0152
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0022 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0849
Echinococcus granulosus GPCR family 2 0.0016 0.0013 0.003
Schistosoma mansoni patched 1 0.0135 0.0242 0.0567
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.002 0.0019 0.0149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.009 0.0756
Brugia malayi cytochrome P450 0.002 0.0019 0.0026
Toxoplasma gondii patched family protein 0.0019 0.0018 0.006
Schistosoma mansoni topbp1 0.0021 0.0022 0.0049
Brugia malayi Muscleblind-like protein 0.0478 0.0902 0.1242
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0022 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0038 0.0263
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.002 0.0039
Trypanosoma brucei telomerase reverse transcriptase 0.1421 0.2718 1
Schistosoma mansoni hypothetical protein 0.0115 0.0203 0.0476
Onchocerca volvulus 0.0022 0.0024 0.0023
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0024 0.0055
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0065 0.0107 0.0969
Echinococcus granulosus expressed conserved protein 0.0296 0.0551 0.1301
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0011 0.0002 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0013 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0127 0.1071
Loa Loa (eye worm) hypothetical protein 0.0478 0.0902 0.6268
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.0356 0.3017
Brugia malayi RNA, U transporter 1 0.0085 0.0145 0.02
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0024 0.0082
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0127 0.0175
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0067
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0001 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.002 0.0167
Schistosoma mansoni microtubule-associated protein tau 0.221 0.4237 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.002 0.0019 0.0161
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.1094
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0001 0.0002
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0024 0.0082
Chlamydia trachomatis protoporphyrinogen oxidase 0.0044 0.0065 0.5059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0084 0.0759
Loa Loa (eye worm) aldehyde dehydrogenase 0.0011 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0067
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0022 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0001 0.0002
Brugia malayi aldehyde dehydrogenase 0.0011 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0008
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0001 0.0003
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0022 0.0017
Mycobacterium tuberculosis Possible oxidoreductase 0.0044 0.0065 0.0583
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0019 0.0018 0.0059
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0127 0.0462
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0024 0.0205
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.002 0.0067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0047 0.0071 0.0254
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0112 0.0262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0001 0.0008
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0024 0.0056
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0203 0.0479
Treponema pallidum DNA ligase (lig) 0.0021 0.0022 0.1931
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.0356 0.3017
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Schistosoma mansoni amine oxidase 0.0044 0.0065 0.015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.002 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0067
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0152
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0001 0.0008
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.002 0.0757
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0013 0.0018
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.0127 0.1071
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.002 0.0067
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0022 0.0044
Echinococcus granulosus twinkle protein mitochondrial 0.0014 0.0008 0.0018
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0024 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0022 0.0075
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0024 0.0082
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.002 0.0019 0.0149
Schistosoma mansoni hypothetical protein 0.0014 0.0008 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0023
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0021 0.0022 0.1622
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0001 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Schistosoma mansoni amine oxidase 0.0044 0.0065 0.015
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0028 0.0097
Toxoplasma gondii hypothetical protein 0.0019 0.0018 0.006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0152
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0022 0.0849
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0024 0.019
Schistosoma mansoni hypothetical protein 0.0014 0.0008 0.0016
Toxoplasma gondii patched family protein 0.0019 0.0018 0.006
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Toxoplasma gondii patched family protein 0.0019 0.0018 0.006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0001 0.0002
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0044 0.0065 0.5051
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0451
Echinococcus multilocularis twinkle protein, mitochondrial 0.0014 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.001
Brugia malayi SWIRM domain containing protein 0.0044 0.0065 0.009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0001 0.0003
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0011 0.0002 0.0003
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.0033
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.062 0.1174 1
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0022 0.0849
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0001 0.0003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.0163
Echinococcus multilocularis protoporphyrinogen oxidase 0.0044 0.0065 0.013
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0039 0.0137
Mycobacterium ulcerans dehydrogenase 0.0044 0.0065 0.0541
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0022 0.0849
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0451
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0008
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0001 0.0002
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1421 0.2718 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0019 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0001 0.0002
Brugia malayi amine oxidase, flavin-containing family protein 0.0044 0.0065 0.009
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0024 0.0082
Giardia lamblia Replication factor C, subunit 1 0.0021 0.0022 0.0075
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.009 0.0269
Giardia lamblia Telomerase catalytic subunit 0.1421 0.2718 1
Entamoeba histolytica hypothetical protein 0.0024 0.0028 0.0448
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0002 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0127 0.2141
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0024 0.0205
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0001 0.0008
Entamoeba histolytica hypothetical protein 0.0021 0.0022 0.0347
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0084 0.0759
Echinococcus granulosus sterol regulatory element binding protein 0.0135 0.0242 0.057
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0137
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0011 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0008
Toxoplasma gondii RNA-directed DNA polymerase 0.1421 0.2718 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0024 0.0081
Brugia malayi hypothetical protein 0.0021 0.0022 0.003
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0067
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.0235 0.1634
Brugia malayi hypothetical protein 0.0021 0.0022 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0081 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0001 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.0862 0.1729
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.002 0.0019 0.0161
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0027
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0022 0.0075
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.002 0.0019 0.0161
Leishmania major cytochrome p450-like protein 0.002 0.0019 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Mycobacterium ulcerans DNA polymerase IV 0.002 0.002 0.0155
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0019 0.0064
Schistosoma mansoni aldehyde dehydrogenase 0.0194 0.0356 0.0836
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0024 0.0205
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.002 0.0019 0.0149
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Echinococcus multilocularis protein patched 0.0135 0.0242 0.0485
Brugia malayi ecdysteroid receptor 0.0011 0.0001 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0127 0.1071
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0024 0.0081
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.002 0.0027
Echinococcus granulosus importin subunit beta 1 0.003 0.0039 0.0091
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.002 0.0019 0.0161
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0024 0.0205
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0023 0.0025 0.0086
Plasmodium falciparum protoporphyrinogen oxidase 0.0044 0.0065 0.0176
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.0127 0.1071
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.002 0.0019 0.0149
Mycobacterium ulcerans monoamine oxidase 0.0044 0.0065 0.0541
Brugia malayi Myosin head containing protein 0.0019 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0478 0.0902 0.6268
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0019 0.0045
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0024 0.0033
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0065 0.0583
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Onchocerca volvulus 0.0022 0.0024 0.0023
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0022 0.0075
Echinococcus multilocularis GPCR, family 2 0.0016 0.0013 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Schistosoma mansoni niemann-pick C1 (NPC1) 0.032 0.0598 0.1408
Brugia malayi Patched related family protein 10 0.0019 0.0018 0.0025
Loa Loa (eye worm) oxidoreductase 0.0022 0.0024 0.0165
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0047 0.0071 0.0634
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0019 0.0018 0.0059
Onchocerca volvulus Protein patched homolog 0.0019 0.0018 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0127 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0024 0.0081
Trichomonas vaginalis ran, putative 0.0022 0.0024 0.0914
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0001 0.0002
Onchocerca volvulus 0.0019 0.0018 0.0017
Leishmania major DNA polymerase eta, putative 0.002 0.002 0.0067
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0024 0.0165
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0081 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0849
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.009 0.0269
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0024 0.0381
Plasmodium falciparum importin beta, putative 0.003 0.0039 0.0079
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0001 0.0003
Brugia malayi Telomerase reverse transcriptase 0.3782 0.7263 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2597 0.4982 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0022 0.0347
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0001 0.0003
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0024 0.0205
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0024 0.0165
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0044 0.0065 0.015
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.002 0.0019 0.0161
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0001 0.0002
Echinococcus granulosus dnaJ subfamily B 0.0457 0.0862 0.2033
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0019 0.0018 0.0059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0152
Brugia malayi Cytochrome P450 family protein 0.003 0.0038 0.0052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0084 0.0759
Loa Loa (eye worm) twinkle helicase 0.0014 0.0008 0.0054
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.062 0.1174 1
Brugia malayi steroid hormone receptor 0.0011 0.0001 0.0002
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0011 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0001 0.0002
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0065 0.0107 1
Brugia malayi DNA polymerase I family protein 0.0019 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0451
Loa Loa (eye worm) hypothetical protein 0.0315 0.0588 0.4086
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0024 0.019
Loa Loa (eye worm) hypothetical protein 0.0135 0.0242 0.1678
Loa Loa (eye worm) hypothetical protein 0.0076 0.0127 0.0883
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0011 0.0002 0.0002
Brugia malayi RNA binding protein 0.0132 0.0235 0.0324
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.0127 0.1154
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.0356 0.3017
Onchocerca volvulus 0.0019 0.0018 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0067
Mycobacterium ulcerans DNA polymerase I 0.0065 0.0107 0.0899
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0022 0.0075
Plasmodium vivax importin-beta 2, putative 0.003 0.0039 0.0079
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0024 0.019
Brugia malayi hypothetical protein 0.0019 0.0018 0.0025
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0024 0.019
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0022 0.0174
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0022 0.0024 0.1777
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Echinococcus multilocularis sterol regulatory element binding protein 0.0135 0.0242 0.0485
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0019 0.0064
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0038 0.0263
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.002 0.0019 0.0161
Loa Loa (eye worm) hypothetical protein 0.0057 0.009 0.0626
Treponema pallidum DNA polymerase I (polA) 0.0065 0.0107 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Echinococcus granulosus survival motor neuron protein 1 0.0757 0.1439 0.3397
Echinococcus multilocularis snurportin 1 0.032 0.0598 0.12
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.002 0.0167
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0127 0.1071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0011 0.0002 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0203 0.0476
Brugia malayi hypothetical protein 0.0044 0.0065 0.009
Brugia malayi Importin beta-1 subunit 0.003 0.0039 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0002
Schistosoma mansoni importin beta-1 0.003 0.0039 0.0089
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0024 0.019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0087
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.002 0.0019 0.0149
Loa Loa (eye worm) hypothetical protein 0.0076 0.0127 0.0883
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.001
Echinococcus multilocularis microtubule associated protein 2 0.221 0.4237 0.8504
Echinococcus granulosus nibrin 0.0021 0.0022 0.0052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0022 0.0849
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0001 0.0008
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.002 0.0019 0.0149
Schistosoma mansoni topbp1 0.0021 0.0022 0.0049
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0019 0.0018 0.0059
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0024 0.093
Brugia malayi Patched related family protein 4 0.0019 0.0018 0.0025
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0451
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0001 0.0002
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0024 0.0082
Brugia malayi hypothetical protein 0.0019 0.0018 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0024 0.0033
Onchocerca volvulus 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.005 0.0343
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.002 0.0019 0.0161
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.002 0.0019 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0001 0.0002
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.0235 0.0324
Schistosoma mansoni hypothetical protein 0.0036 0.005 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0024 0.0033
Brugia malayi Cytochrome P450 family protein 0.002 0.0019 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0127 0.0175
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0022 0.003
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0011 0.0002 0.0003
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0057 0.009 0.8021
Echinococcus multilocularis expressed conserved protein 0.0296 0.0551 0.1106
Plasmodium falciparum telomerase reverse transcriptase 0.1421 0.2718 1
Onchocerca volvulus 0.0021 0.0022 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0235 0.0552
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0127 0.0175
Echinococcus granulosus dna polymerase kappa 0.002 0.002 0.0046
Onchocerca volvulus 0.0019 0.0018 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.002 0.0019 0.0161
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.002 0.0067
Schistosoma mansoni DNA polymerase I 0.0019 0.0018 0.0038
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0044 0.0065 0.0176
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0011 0.0002 0.0002
Plasmodium falciparum lipid/sterol:H+ symporter 0.0019 0.0018 0.0001
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0451
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0024 0.0082
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0127 0.2141
Schistosoma mansoni hypothetical protein 0.013 0.0232 0.0545
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0121
Schistosoma mansoni DNA polymerase eta 0.002 0.002 0.0044
Brugia malayi CXXC zinc finger family protein 0.0032 0.0043 0.0059
Brugia malayi nuclear receptor NHR-88 0.0011 0.0001 0.0002
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0019 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0001 0.0002
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0047 0.0071 0.0254
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0152
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.002 0.0019 0.0149
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.002 0.0137
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0024 0.0205
Mycobacterium ulcerans 5'-3' exonuclease 0.0047 0.0071 0.0588
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.0081
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0021 0.0022 0.1931
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.002 0.0019 0.0161
Leishmania major cytochrome p450-like protein 0.002 0.0019 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0067
Echinococcus multilocularis muscleblind protein 1 0.0478 0.0902 0.1811
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0023
Schistosoma mansoni aldehyde dehydrogenase 0.0194 0.0356 0.0836
Brugia malayi Niemann-Pick C1 protein precursor 0.0315 0.0588 0.081
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0011 0.0002 0.0003
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0024 0.019
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0127 0.0462
Echinococcus granulosus lysine specific histone demethylase 1A 0.0044 0.0065 0.0153
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0576 0.109 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0067
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0024 0.0082
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0019 0.1393
Entamoeba histolytica Ran family GTPase 0.0022 0.0024 0.0374
Loa Loa (eye worm) hypothetical protein 0.0057 0.009 0.0626
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0024 0.0081
Echinococcus granulosus microtubule associated protein 2 0.221 0.4237 1
Plasmodium vivax patched family protein, putative 0.0019 0.0018 0.0001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0013 0.0025
Echinococcus granulosus muscleblind protein 0.0478 0.0902 0.2129
Schistosoma mansoni cpg binding protein 0.0032 0.0043 0.0098
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.002 0.0757
Echinococcus multilocularis survival motor neuron protein 1 0.0757 0.1439 0.2889
Brugia malayi Cytochrome P450 family protein 0.003 0.0038 0.0052
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0065 0.0107 0.8399
Schistosoma mansoni hypothetical protein 0.002 0.0019 0.0042
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0046 0.0069 0.0247
Brugia malayi protein C24B5.3 0.0019 0.0018 0.0025
Echinococcus granulosus lysine specific histone demethylase 1A 0.0044 0.0065 0.0153
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0024 0.019
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0315 0.0588 1
Loa Loa (eye worm) patched family protein 0.0019 0.0018 0.0123
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0024 0.0082
Onchocerca volvulus 0.0019 0.0018 0.0017
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0011 0.0002 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.002 0.0019 0.0161
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0203 0.0407
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0024 0.019
Entamoeba histolytica hypothetical protein 0.0115 0.0203 0.3431
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0849
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0024 0.0053
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0044 0.0065 0.0541
Echinococcus granulosus Protein patched homolog 1 0.0135 0.0242 0.057
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0067
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.002 0.0019 0.0149
Schistosoma mansoni cpg binding protein 0.0034 0.0046 0.0106
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0101 0.0703
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0044 0.0065 0.0176
Echinococcus granulosus snurportin 1 0.032 0.0598 0.1411
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.002 0.0067
Leishmania major DNA polymerase kappa, putative 0.002 0.002 0.0067
Onchocerca volvulus 0.0022 0.0024 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0001 0.0002
Echinococcus multilocularis 0.002 0.0019 0.0038
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0043 0.0297
Schistosoma mansoni hypothetical protein 0.0457 0.0862 0.2031
Chlamydia trachomatis DNA polymerase I 0.0065 0.0107 1
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0024 0.1777
Onchocerca volvulus 0.0154 0.0279 0.0277
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.002 0.0019 0.0149
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.002 0.0019 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0115 0.0203 0.3431
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.002 0.0044
Echinococcus multilocularis Niemann Pick C1 protein 0.0451 0.0849 0.1703
Brugia malayi TAR-binding protein 0.0132 0.0235 0.0324
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0022 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0067
Loa Loa (eye worm) patched family protein 0.0019 0.0018 0.0123
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.002 0.0019 0.0149
Loa Loa (eye worm) patched family protein 0.0019 0.0018 0.0123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0001 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0067
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0002 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0001 0.0002
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0038 0.0134
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.0127 0.2141
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0451
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0194 0.0356 0.0713
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0018 0.015
Schistosoma mansoni hypothetical protein 0.0154 0.0279 0.0654
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1421 0.2718 1
Toxoplasma gondii helicase, putative 0.0019 0.0018 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.002 0.0019 0.0149
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0024 0.019
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0057 0.009 0.0626
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.0127 0.1071
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0024 0.0082
Schistosoma mansoni survival motor neuron protein 0.0154 0.0279 0.0654
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0047 0.0071 0.0197
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0001 0.0008
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0044 0.0065 0.015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Leishmania major importin beta-1 subunit, putative 0.0024 0.0028 0.0097
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0024 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0001 0.0008
Brugia malayi Patched protein homolog 1 0.0019 0.0018 0.0025
Echinococcus multilocularis muscleblind protein 0.0478 0.0902 0.1811
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0013 0.0087
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0022 0.0849
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0154 0.0279 0.0383
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.002 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0127 0.1154
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0067
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.002 0.0027
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0011 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0027
Toxoplasma gondii patched family protein 0.0019 0.0018 0.006
Echinococcus multilocularis importin subunit beta 1 0.003 0.0039 0.0078
Loa Loa (eye worm) hypothetical protein 0.0076 0.0127 0.0883
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0022 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0235 0.0552
Loa Loa (eye worm) TAR-binding protein 0.0132 0.0235 0.1634
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0065 0.0176
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0011 0.0002 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0084 0.0759
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0024 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0001 0.0003
Brugia malayi hypothetical protein 0.0757 0.1439 0.1982
Loa Loa (eye worm) hypothetical protein 0.003 0.0039 0.0269
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0028 0.1094
Mycobacterium ulcerans oxidoreductase 0.0044 0.0065 0.0541
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.002 0.0019 0.0161
Trypanosoma brucei unspecified product 0.002 0.002 0.0067
Loa Loa (eye worm) cytochrome P450 0.002 0.0019 0.0132
Loa Loa (eye worm) hypothetical protein 0.0057 0.009 0.0626
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0019 0.0018 0.0271
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0011 0.0002 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0235 0.0552
Loa Loa (eye worm) RNA binding protein 0.0132 0.0235 0.1634
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0038 0.031
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0011 0.0002 0.001
Echinococcus multilocularis nibrin 0.0021 0.0022 0.0044
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0024 0.0205
Onchocerca volvulus 0.0022 0.0024 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0001 0.0008
Leishmania major telomerase reverse transcriptase, putative 0.1421 0.2718 1
Entamoeba histolytica hypothetical protein 0.0115 0.0203 0.3431
Schistosoma mansoni hypothetical protein 0.013 0.0232 0.0545
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0039 0.0137
Loa Loa (eye worm) patched family protein 0.0019 0.0018 0.0123
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0194 0.0356 0.1303
Schistosoma mansoni hypothetical protein 0.013 0.0232 0.0545
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0165
Brugia malayi hypothetical protein 0.0115 0.0203 0.0279
Onchocerca volvulus 0.0044 0.0065 0.0064
Brugia malayi CHE-14 protein 0.0135 0.0242 0.0333
Toxoplasma gondii aldehyde dehydrogenase 0.0194 0.0356 0.1303
Schistosoma mansoni cytochrome P450 0.002 0.0019 0.0042
Trypanosoma brucei cytochrome P450, putative 0.003 0.0038 0.0134
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0019 0.0018 0.0059
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0127 0.1071
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.0598 0.4154
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0024 0.0033
Plasmodium vivax telomerase reverse transcriptase, putative 0.1421 0.2718 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0019 0.0064
Brugia malayi protein C24B5.3 0.0019 0.0018 0.0025
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.002 0.0019 0.0149
Brugia malayi hypothetical protein 0.0019 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0757 0.1439 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.002 0.0019 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.0242 1
Brugia malayi Cytochrome P450 family protein 0.0062 0.0101 0.014
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0039 0.0137
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0047 0.0071 0.0254
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0098 0.0355
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0081 0.0112
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0024 0.0205
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.002 0.0019 0.0161
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0013 0.003
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0024 0.0082
Onchocerca volvulus 0.0019 0.0018 0.0017
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.002 0.0019 0.0149
Leishmania major UDP-galactopyranose mutase 0.0044 0.0065 0.0234
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.002 0.0019 0.0149
Loa Loa (eye worm) patched family protein 0.0019 0.0018 0.0123
Schistosoma mansoni hypothetical protein 0.013 0.0232 0.0545
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0001 0.0002
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0023
Echinococcus multilocularis tar DNA binding protein 0.0132 0.0235 0.0472
Brugia malayi Aldehyde dehydrogenase protein 4 0.0011 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.002 0.0019 0.0149
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0008
Onchocerca volvulus Protein patched homolog 0.0019 0.0018 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0001 0.0002
Toxoplasma gondii histone lysine-specific demethylase 0.0044 0.0065 0.0234
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0024 0.0022
Onchocerca volvulus 0.0032 0.0043 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0235 0.0552
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.002 0.0019 0.0161
Echinococcus multilocularis protein dispatched 1 0.0154 0.0278 0.0559
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Brugia malayi Patched related family protein 12 0.0019 0.0018 0.0025
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0052 0.0081 0.0563
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0065 0.0176
Schistosoma mansoni hypothetical protein 0.0011 0.0002 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.002 0.0019 0.0161
Giardia lamblia DINP protein human, muc B family 0.002 0.002 0.0067
Echinococcus multilocularis Niemann Pick C1 protein 0.0315 0.0588 0.118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0011 0.0002 0.0003
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0194 0.0356 0.325
Echinococcus multilocularis cpg binding protein 0.0034 0.0046 0.0093
Entamoeba histolytica hypothetical protein 0.0115 0.0203 0.3431
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0038 0.0134
Leishmania major GTP-binding protein, putative 0.0022 0.0024 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0235 0.0552
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0152
Onchocerca volvulus 0.0076 0.0127 0.0126
Schistosoma mansoni ran 0.0022 0.0024 0.0052
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.1094
Echinococcus granulosus tar DNA binding protein 0.0132 0.0235 0.0555
Mycobacterium leprae putative cytochrome p450 0.002 0.0019 0.1393
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0013 0.003
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0024 0.0205
Mycobacterium ulcerans hypothetical protein 0.0076 0.0127 0.1071
Schistosoma mansoni DNA ligase IV 0.0021 0.0022 0.0049
Leishmania major cytochrome p450-like protein 0.003 0.0038 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0067
Echinococcus granulosus Niemann Pick C1 protein 0.0451 0.0849 0.2003
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0044 0.0065 0.013
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0165
Schistosoma mansoni cpg binding protein 0.0034 0.0046 0.0106
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.002 0.0019 0.0149
Echinococcus granulosus Niemann Pick C1 protein 0.0315 0.0588 0.1388
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0127 0.0462
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0044 0.0065 0.0176
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Brugia malayi Patched family protein 0.0019 0.0018 0.0025
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0024 0.0082
Trichomonas vaginalis DNA polymerase I, putative 0.0019 0.0018 0.0663
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0014 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0166 0.03 0.2085
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.002 0.0067
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0135 0.0242 0.1678
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0022 0.0075
Brugia malayi topoisomerase 0.0021 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0123
Trypanosoma cruzi UDP-galactopyranose mutase 0.0044 0.0065 0.0234
Echinococcus multilocularis dna polymerase eta 0.002 0.002 0.0039
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0001 0.0002

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2300 nM Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]-OXO-M as radioligand ChEMBL. 1560440
IC50 (binding) = 2300 nM Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]-OXO-M as radioligand ChEMBL. 1560440
IC50 (binding) = 115000 nM Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]-QNB as radioligand ChEMBL. 1560440
IC50 (binding) = 115000 nM Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]-QNB as radioligand ChEMBL. 1560440
Ratio (binding) = 49 Ratio of IC50(QNB) to IC50(OXO-M) was determined ChEMBL. 1560440

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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