Detailed information for compound 34819

Basic information

Technical information
  • TDR Targets ID: 34819
  • Name: 3-(dimethylamino)propane-1,2-diol
  • MW: 119.162 | Formula: C5H13NO2
  • H donors: 2 H acceptors: 2 LogP: -1.04 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(CN(C)C)O
  • InChi: 1S/C5H13NO2/c1-6(2)3-5(8)4-7/h5,7-8H,3-4H2,1-2H3
  • InChiKey: QCMHUGYTOGXZIW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-Dimethylaminopropane-1,2-diol
  • 98923-15-0
  • 623-57-4
  • 1,2-Propanediol, 3-(dimethylamino)-
  • 3-(Dimethylamino)-1,2-propanediol
  • Dimethylamino-2,3-propanediol
  • NSC8655
  • AI3-15482
  • 3-Dimethylamino-1,2-propanediol
  • AIDS-018600
  • AIDS018600
  • 210218_ALDRICH
  • EINECS 210-802-4
  • NSC 8655

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0048 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0028 0.0632
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0001 0.0000098982
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0021 0.0314
Giardia lamblia Inositol 5-phosphatase 4 0.0008 0.0002 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0021 0.0028
Entamoeba histolytica hypothetical protein 0.0042 0.0049 0.0846
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0008 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0021 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0008 0.0117
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0021 0.0308
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0028 0.0632
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0005 0.0093
Schistosoma mansoni neutral sphingomyelinase 0.0008 0.0002 0.0029
Echinococcus multilocularis lamin 0.0028 0.0029 0.0442
Brugia malayi nuclear receptor NHR-88 0.0022 0.0021 0.0028
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0008 0.0117
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0354 0.048 0.1763
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Echinococcus multilocularis muscleblind protein 1 0.0175 0.0233 0.3554
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0021 0.0028
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0009 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0008 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0021 0.0419
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0011 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Trypanosoma cruzi mitochondrial protein 99, putative 0.0008 0.0002 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0001 0.0000098982
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0048 0.0176
Echinococcus multilocularis smad 0.001 0.0003 0.0048
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0005 0.0064
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0021 0.0314
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0419
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0029 0.0597
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0122
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0005 0.0064
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0008 0.0117
Plasmodium falciparum telomerase reverse transcriptase 0.1975 0.2724 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Echinococcus granulosus neuropeptide receptor 0.0013 0.0008 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0044
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0016 0.0058
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0029 0.0597
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0419
Echinococcus granulosus Ankyrin 0.0015 0.0011 0.0166
Brugia malayi Melatonin receptor type 1A 0.0013 0.0008 0.0011
Echinococcus multilocularis dna polymerase eta 0.0023 0.0022 0.0325
Echinococcus granulosus lamin dm0 0.0028 0.0029 0.0442
Schistosoma mansoni netrin receptor unc5 0.0015 0.0011 0.0169
Brugia malayi conserved hypotetical protein 0.001 0.0005 0.0006
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0022 0.0079
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0022 0.0325
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.0008 0.0122
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0011 0.0015
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0008 0.0002 0.0025
Brugia malayi steroid hormone receptor 0.0022 0.0021 0.0028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0049 0.0739
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.0008 0.0117
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0006 0.009
Echinococcus multilocularis synaptojanin 1 0.0008 0.0002 0.0024
Brugia malayi hypothetical protein 0.0013 0.0008 0.0011
Brugia malayi BRM protein 0.0079 0.0099 0.0137
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0033 0.0732
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0008 0.0002 0.0007
Echinococcus granulosus importin subunit beta 1 0.0034 0.0037 0.0561
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0022 0.0079
Leishmania major telomerase reverse transcriptase, putative 0.1975 0.2724 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Schistosoma mansoni amine GPCR 0.0013 0.0008 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Echinococcus granulosus geminin 0.0199 0.0265 0.4052
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0008 0.0117
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0033 0.0664
Onchocerca volvulus 0.0013 0.0008 0.0006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0008 0.0122
Trypanosoma brucei unspecified product 0.0016 0.0012 0.0044
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0008 0.0117
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0008 0.0117
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0016 0.0058
Brugia malayi G protein-coupled receptor 0.0013 0.0008 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0008 0.0122
Echinococcus multilocularis neuropeptide receptor A26 0.0013 0.0008 0.0117
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0081 0.0299
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0419
Giardia lamblia Telomerase catalytic subunit 0.1975 0.2724 1
Schistosoma mansoni hypothetical protein 0.0014 0.0009 0.014
Echinococcus multilocularis global transcription activator snf2l2 0.0079 0.0099 0.1513
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0021 0.0308
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0134
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0021 0.0314
Brugia malayi hypothetical protein 0.0013 0.0008 0.0011
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0023
Brugia malayi Smad1 0.001 0.0003 0.0005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0021 0.0314
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus multilocularis serotonin receptor 0.016 0.0212 0.3231
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0005 0.0003
Echinococcus multilocularis orexin receptor type 2 0.0013 0.0008 0.0117
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0009 0.0031
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0053
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0002 0.0007
Brugia malayi hypothetical protein 0.0042 0.0049 0.0067
Schistosoma mansoni helicase 0.0079 0.0099 0.1518
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0008 0.0117
Loa Loa (eye worm) CXXC zinc finger family protein 0.0073 0.0091 0.1863
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0048 0.1088
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0005 0.007
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0168 0.0222 0.0816
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0005 0.0006
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0023 0.0022 0.0082
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0021 0.0308
Brugia malayi Muscleblind-like protein 0.0175 0.0233 0.032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0001 0.0000098982
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0005 0.0064
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0002 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0021 0.0308
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0023 0.0022 0.0082
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0185
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0021 0.0019
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0122
Schistosoma mansoni cpg binding protein 0.0075 0.0094 0.1436
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0021 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0229
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.0008 0.0117
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0.0008 0.0011
Giardia lamblia hypothetical protein 0.0008 0.0002 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0048 0.0176
Leishmania major hypothetical protein, conserved 0.0008 0.0002 0.0007
Mycobacterium tuberculosis Conserved hypothetical protein 0.0186 0.0248 1
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0407 0.0554 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0009 0.0031
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.0008 0.0117
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0002 0.0023
Brugia malayi Dopamine receptor protein 2 0.0013 0.0008 0.0011
Leishmania major protein kinase, putative 0.0013 0.0009 0.0031
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0048 0.1106
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0053
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0134
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0021 0.0314
Onchocerca volvulus 0.0038 0.0042 0.004
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0037 0.0136
Schistosoma mansoni smad 0.001 0.0003 0.0053
Brugia malayi larval opioid receptor 0.0013 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0128
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0022 0.003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0022 0.0798
Schistosoma mansoni biogenic amine receptor 0.0013 0.0008 0.0122
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0021 0.0308
Echinococcus multilocularis musashi 0.0028 0.0029 0.0442
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0045 0.0053 0.0807
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0008 0.0002 0.0024
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0169
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0021 0.0019
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0037 0.0136
Brugia malayi MH2 domain containing protein 0.001 0.0003 0.0005
Loa Loa (eye worm) melatonin receptor type 1A 0.0013 0.0008 0.0163
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0128
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0033 0.0119
Brugia malayi polybromodomain protein 0.0007 0 0.0001
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0021 0.0308
Echinococcus multilocularis somatostatin receptor 0.0013 0.0008 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0021 0.0028
Schistosoma mansoni opsin-like receptor 0.0013 0.0008 0.0122
Trichomonas vaginalis Phospholipase C precursor, putative 0.0008 0.0002 0.0025
Schistosoma mansoni nuclear receptor 0.001 0.0005 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0178
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0006 0.0096
Entamoeba histolytica hypothetical protein 0.0027 0.0028 0.0476
Brugia malayi Telomerase reverse transcriptase 0.5256 0.7266 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0008 0.0117
Mycobacterium leprae Possible regulatory protein 0.0013 0.0009 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0021 0.0419
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1975 0.2724 1
Echinococcus multilocularis Ankyrin 0.0015 0.0011 0.0166
Onchocerca volvulus 0.0013 0.0008 0.0006
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0008 0.0002 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0008 0.0002 0.0007
Giardia lamblia DINP protein human, muc B family 0.0023 0.0022 0.0079
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0008 0.0002 0.0007
Brugia malayi glutaminase DH11.1 0.032 0.0434 0.0597
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0011 0.0169
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Schistosoma mansoni hypothetical protein 0.0008 0.0002 0.0029
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0005 0.0064
Echinococcus granulosus g protein coupled receptor 0.0013 0.0008 0.0117
Onchocerca volvulus 0.0013 0.0008 0.0006
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0042 0.0975
Brugia malayi hypothetical protein 0.0012 0.0006 0.0009
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0008 0.0117
Plasmodium falciparum flap endonuclease 1 0.0031 0.0033 0.0119
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.0066
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0008 0.0117
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0354 0.048 0.1763
Onchocerca volvulus 0.0013 0.0009 0.0007
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0005 0.0003
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0016 0.0325
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus granulosus neutral sphingomyelinase 0.0008 0.0002 0.0024
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0037 0.0561
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0005 0.0006
Loa Loa (eye worm) DR-78 0.001 0.0005 0.0093
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0175
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0037 0.0136
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Brugia malayi isocitrate dehydrogenase 0.0019 0.0016 0.0022
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0033 0.0119
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0028 0.0632
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0122
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0002 0.0003
Echinococcus multilocularis lamin dm0 0.0028 0.0029 0.0442
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0023 0.0022 0.0336
Schistosoma mansoni biogenic amine receptor 0.0013 0.0008 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0178
Brugia malayi neuropeptide F receptor 0.0013 0.0008 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0003 0.0071
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0021 0.0314
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0022 0.0798
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0009 0.0178
Brugia malayi hypothetical protein 0.001 0.0005 0.0006
Brugia malayi hypothetical protein 0.0013 0.0008 0.0011
Schistosoma mansoni amine GPCR 0.0013 0.0008 0.0122
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0.0008 0.0011
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0033 0.0119
Loa Loa (eye worm) hypothetical protein 0.0008 0.0002 0.0039
Brugia malayi Uncoordinated protein 44 0.0015 0.0011 0.0015
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0009 0.0133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0008 0.0122
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0009 0.0133
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0008 0.0117
Brugia malayi hypothetical protein 0.0013 0.0008 0.0011
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0097 0.1473
Schistosoma mansoni neuropeptide receptor 0.0013 0.0008 0.0122
Onchocerca volvulus 0.001 0.0005 0.0003
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0008 0.0002 0.0025
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0042 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0419
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0021 0.0308
Brugia malayi Disco-interacting protein 2 homolog 0.0045 0.0053 0.0073
Echinococcus granulosus dnaJ subfamily B 0.0479 0.0654 1
Onchocerca volvulus 0.0013 0.0008 0.0006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0048 0.0979
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0002 0.0028
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0008 0.0117
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.0008 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Brugia malayi hypothetical protein 0.017 0.0226 0.0311
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0016 0.0238
Schistosoma mansoni glutaminase 0.032 0.0434 0.6634
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0011 0.0163
Trypanosoma brucei RNA editing exonuclease 2 0.0008 0.0002 0.0007
Schistosoma mansoni nocturnin 0.0008 0.0002 0.0029
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0022 0.0079
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.0008 0.0122
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0011 0.0015
Echinococcus multilocularis sex peptide receptor 0.0013 0.0008 0.0117
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0.0008 0.0011
Brugia malayi Death domain containing protein 0.0015 0.0011 0.0015
Trypanosoma cruzi mitochondrial protein 99, putative 0.0008 0.0002 0.0007
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0008 0.0117
Schistosoma mansoni lamin 0.0028 0.0029 0.0447
Brugia malayi hypothetical protein 0.0013 0.0008 0.0011
Schistosoma mansoni amine GPCR 0.0013 0.0008 0.0122
Loa Loa (eye worm) hypothetical protein 0.0007 0 0.0008
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0011 0.0228
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0008 0.0117
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0002 0.0039
Mycobacterium ulcerans hypothetical protein 0.0186 0.0248 0.5726
Onchocerca volvulus 0.0013 0.0008 0.0006
Brugia malayi hypothetical protein 0.0013 0.0008 0.0011
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0005 0.0006
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0003 0.0048
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0003 0.0071
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0419
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0003 0.0048
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0016 0.0568
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0021 0.0308
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0006 0.0096
Brugia malayi hypothetical protein 0.001 0.0005 0.0006
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0002 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0.0008 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0008 0.0163
Echinococcus multilocularis Chromo domain 0.0014 0.0009 0.0134
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0021 0.0314
Schistosoma mansoni nuclear receptor 0.001 0.0005 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0001 0.0000098982
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0002 0.0007
Schistosoma mansoni ap endonuclease 0.0042 0.0048 0.0733
Plasmodium falciparum DNase I-like protein, putative 0.0008 0.0002 0.0007
Brugia malayi nuclear receptor RXR 0.001 0.0005 0.0006
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0008 0.0002 0.0007
Schistosoma mansoni adenoreceptor 0.0013 0.0008 0.0122
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0021 0.0308
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0008 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0021 0.0028
Brugia malayi SET domain containing protein 0.0008 0.0001 0.0002
Echinococcus granulosus serotonin receptor 0.0013 0.0008 0.0117
Echinococcus granulosus biogenic amine 5HT receptor 0.016 0.0212 0.3231
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0021 0.0314
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Onchocerca volvulus 0.0013 0.0008 0.0006
Echinococcus granulosus smad 0.001 0.0003 0.0048
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.0008 0.0122
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0014 0.0009 0.0134
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0048 0.0176
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0008 0.0122
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0016 0.0238
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0009 0.0031
Brugia malayi RE15519p 0.0013 0.0008 0.0011
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0008 0.0002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0226
Echinococcus granulosus hypothetical protein 0.0013 0.0008 0.0117
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0016 0.0022
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0134
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0008 0.0117
Schistosoma mansoni nuclear hormone receptor 0.001 0.0005 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0001 0.0000098982
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0021 0.0419
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0008 0.0117
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0008 0.0002 0.0007
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0011 0.0172
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.0008 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0021 0.0028
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0008 0.0117
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0011 0.0226
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0008 0.0117
Onchocerca volvulus 0.0022 0.0021 0.0019
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0002 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0044
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0008 0.0117
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0005 0.0093
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0005 0.0064
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0021 0.0308
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0005 0.007
Leishmania major importin beta-1 subunit, putative 0.0027 0.0028 0.0104
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0 0.0003
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0053
Echinococcus granulosus Chromo domain 0.0014 0.0009 0.0134
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0002 0.0007
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.0008 0.0117
Brugia malayi hypothetical protein 0.0013 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0128
Schistosoma mansoni myosin xvIII 0.0013 0.0008 0.0122
Echinococcus granulosus snurportin 1 0.0361 0.049 0.7488
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0016 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Onchocerca volvulus 0.0028 0.0029 0.0027
Schistosoma mansoni neuropeptide receptor 0.0013 0.0008 0.0122
Brugia malayi Serotonin receptor 0.0013 0.0008 0.0011
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0008 0.0002 0.0007
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.0008 0.0117
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0022 0.0356
Echinococcus granulosus dna polymerase eta 0.0023 0.0022 0.0325
Plasmodium vivax telomerase reverse transcriptase, putative 0.1975 0.2724 1
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0002 0.0024
Schistosoma mansoni carbon catabolite repressor protein 0.0008 0.0002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0002 0.0039
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0008 0.0002 0.0007
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0008 0.0002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Brugia malayi nuclear hormone receptor 0.001 0.0005 0.0006
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0008 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0021 0.0028
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0048 0.0066
Loa Loa (eye worm) glutaminase 0.032 0.0434 0.8858
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0168 0.0222 0.0816
Loa Loa (eye worm) hypothetical protein 0.0008 0.0002 0.0039
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0002 0.0007
Echinococcus granulosus somatostatin receptor 0.0013 0.0008 0.0117
Entamoeba histolytica hypothetical protein 0.0042 0.0049 0.0846
Brugia malayi ORL1-like opioid receptor 0.0013 0.0008 0.0011
Leishmania major endonuclease/exonuclease protein-like protein 0.0008 0.0002 0.0007
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0006 0.0128
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0002 0.0007
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0013 0.0008 0.0006
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0008 0.0117
Trichomonas vaginalis lymphoid specific helicase, putative 0.0014 0.001 0.0214
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0021 0.0028
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0033 0.0554
Schistosoma mansoni DNA polymerase eta 0.0023 0.0022 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0008 0.0117
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.0008 0.0117
Brugia malayi hypothetical protein 0.0012 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.0042 0.0049 0.0744
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0005 0.007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Leishmania major protein kinase, putative 0.0013 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0419
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Brugia malayi MH2 domain containing protein 0.001 0.0003 0.0005
Echinococcus granulosus neuropeptide receptor A26 0.0013 0.0008 0.0117
Echinococcus granulosus intermediate filament protein 0.0028 0.0029 0.0442
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Echinococcus granulosus BRK domain containing protein 0.0014 0.0009 0.0134
Loa Loa (eye worm) TYRA-2 protein 0.0013 0.0008 0.0163
Loa Loa (eye worm) hypothetical protein 0.016 0.0212 0.432
Brugia malayi hypothetical protein 0.0013 0.0008 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.018
Echinococcus granulosus disco interacting protein 2 0.0045 0.0053 0.0802
Brugia malayi nuclear hormone receptor 0.0022 0.0021 0.0028
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0022 0.033
Loa Loa (eye worm) hypothetical protein 0.0008 0.0002 0.0039
Brugia malayi intermediate filament protein 0.0028 0.0029 0.004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0128
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0048 0.0176
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0008 0.0117
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0016 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Schistosoma mansoni cpg binding protein 0.0075 0.0094 0.1436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0021 0.0419
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0012 0.0007 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0021 0.0308
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0002 0.0023
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0002 0.0003
Plasmodium falciparum importin beta, putative 0.0034 0.0037 0.0136
Schistosoma mansoni Smad4 0.001 0.0003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Brugia malayi ecdysone receptor 0.001 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus granulosus synaptojanin 1 0.0008 0.0002 0.0024
Brugia malayi CXXC zinc finger family protein 0.0073 0.0091 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Brugia malayi Dopamine receptor protein 1 0.0013 0.0008 0.0011
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0005 0.0064
Echinococcus multilocularis serotonin receptor 0.016 0.0212 0.3231
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0008 0.0117
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0002 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0008 0.0122
Schistosoma mansoni hypothetical protein 0.0479 0.0654 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0053 0.1078
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Brugia malayi PAS domain containing protein 0.0051 0.0061 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0021 0.0028
Loa Loa (eye worm) hypothetical protein 0.0175 0.0233 0.4751
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0171
Echinococcus granulosus neuropeptide s receptor 0.0013 0.0008 0.0117
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0.0008 0.0011
Trypanosoma brucei telomerase reverse transcriptase 0.1975 0.2724 1
Loa Loa (eye worm) hypothetical protein 0.016 0.0212 0.432
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.0008 0.0117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0021 0.0308
Onchocerca volvulus 0.0028 0.0029 0.0027
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0048 0.0176
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0128 0.0468
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0059 0.0217
Entamoeba histolytica hypothetical protein 0.0042 0.0049 0.0846
Onchocerca volvulus 0.0013 0.0008 0.0006
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0022 0.0441
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0002 0.0007
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0002 0.0025
Echinococcus granulosus lamin 0.0028 0.0029 0.0442
Echinococcus granulosus neuropeptide receptor 0.0013 0.0008 0.0117
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0002 0.0007
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0042 0.0641
Echinococcus granulosus global transcription activator snf2l2 0.0079 0.0099 0.1513
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0009 0.0178
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0008 0.0002 0.0039
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0361 0.049 1
Brugia malayi G-protein coupled receptor 0.0013 0.0008 0.0011
Trypanosoma brucei unspecified product 0.0023 0.0022 0.0079
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0048 0.0833
Loa Loa (eye worm) hypothetical protein 0.0034 0.0037 0.0757
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0016 0.0238
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0008 0.0002 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0021 0.0028
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0002 0.0007
Entamoeba histolytica hypothetical protein 0.0116 0.0151 0.2694
Brugia malayi CCR4 0.0008 0.0002 0.0003
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.0008 0.0122
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0021 0.0314
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0009 0.0125
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0013 0.0008 0.0163
Onchocerca volvulus 0.0013 0.0008 0.0006
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.0008 0.0117
Echinococcus multilocularis dnaJ subfamily B 0.0479 0.0654 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0005 0.0096
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0022 0.0079
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.0008 0.0117
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0354 0.048 0.1763
Brugia malayi GnHR receptor homolog 0.0013 0.0008 0.0011
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0021 0.0314
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0033 0.0119
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0002 0.0003
Toxoplasma gondii hypothetical protein 0.0099 0.0128 0.0468
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0.0008 0.0011
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0028 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0008 0.0122
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0008 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0011 0.0163
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0048 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0008 0.0122
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0008 0.0117
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.0184 0.3757
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0008 0.0122
Trypanosoma brucei unspecified product 0.0016 0.0012 0.0044
Onchocerca volvulus 0.0013 0.0008 0.0006
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0013 0.0008 0.0163
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0048 0.1088
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0016 0.0238
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0033 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0009 0.0178
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0022 0.0498
Loa Loa (eye worm) hypothetical protein 0.0008 0.0002 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Leishmania major DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Schistosoma mansoni hypothetical protein 0.0361 0.049 0.7489
Onchocerca volvulus 0.0073 0.0091 0.0089
Leishmania major hypothetical protein, conserved 0.0008 0.0002 0.0007
Schistosoma mansoni single-minded 0.0051 0.0061 0.0926
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.0008 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0008 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0008 0.0122
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0597
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0005
Echinococcus granulosus Smad4 0.001 0.0003 0.0048
Schistosoma mansoni cpg binding protein 0.0073 0.0091 0.1395
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0021 0.0308
Leishmania major modification methylase-like protein 0.0023 0.0022 0.0082
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0005 0.0006
Schistosoma mansoni nuclear hormone receptor 0.001 0.0005 0.007
Brugia malayi hypoxia-induced factor 1 0.0157 0.0208 0.0286
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Echinococcus granulosus g protein coupled receptor 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.0175 0.0233 0.4751
Loa Loa (eye worm) Smad1 0.001 0.0003 0.0071
Onchocerca volvulus 0.0045 0.0053 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0016 0.0238
Schistosoma mansoni hypothetical protein 0.0199 0.0265 0.4056
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0022 0.0325
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0002 0.0007
Onchocerca volvulus Neuropeptide F receptor homolog 0.0013 0.0008 0.0006
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0021 0.0308
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0006 0.0009
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0008 0.0117
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.0074 0.0273
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0021 0.0019
Loa Loa (eye worm) helicase DNA-binding protein 0.0014 0.0009 0.0187
Toxoplasma gondii exonuclease III APE 0.0042 0.0048 0.0176
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0021 0.0308
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0002 0.0003
Echinococcus multilocularis BRK domain 0.0014 0.0009 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.0008 0.0122
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0008 0.0002 0.0025
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0048 0.0176
Brugia malayi ecdysteroid receptor 0.0022 0.0021 0.0028
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0008 0.0002 0.0007
Brugia malayi MH2 domain containing protein 0.014 0.0184 0.0253
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0003 0.0048
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0122
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0009 0.0031
Onchocerca volvulus 0.0013 0.0008 0.0006
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0097 0.1473
Brugia malayi tailless protein 0.001 0.0005 0.0006
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0048 0.0176
Loa Loa (eye worm) hypothetical protein 0.017 0.0226 0.4616
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0013 0.0008 0.0163
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0023 0.0022 0.0082
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0021 0.0028
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0008 0.0122
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0022 0.033
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0008 0.0117
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0009 0.0175
Leishmania major pantothenate kinase subunit, putative 0.0008 0.0002 0.0007
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0014 0.001 0.0037
Brugia malayi nuclear receptor NHR-88 0.001 0.0005 0.0006
Schistosoma mansoni flap endonuclease-1 0.0028 0.0028 0.0435
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0009 0.0031
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0011 0.0009
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0002 0.0007
Onchocerca volvulus 0.0013 0.0008 0.0006
Onchocerca volvulus 0.0013 0.0008 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0001 0.0000098982
Brugia malayi hypothetical protein 0.0013 0.0008 0.0011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.0008 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0021 0.0419
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0033 0.0492
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0005 0.0093
Schistosoma mansoni importin beta-1 0.0034 0.0037 0.0567
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0029 0.004
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0419
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0002 0.0025
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0022 0.0498
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0007 0.0027
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0002 0.0007
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0008 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Schistosoma mansoni synaptojanin 0.0008 0.0002 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0089 0.1363
Brugia malayi Serotonin receptor 0.0013 0.0008 0.0011
Loa Loa (eye worm) BRM protein 0.005 0.006 0.1223
Echinococcus multilocularis neuropeptide s receptor 0.0013 0.0008 0.0117
Schistosoma mansoni polybromo-1 0.0007 0 0.0006
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0002 0.0007
Schistosoma mansoni neuropeptide receptor 0.0013 0.0008 0.0122
Brugia malayi AKH receptor 0.0013 0.0008 0.0011
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0002 0.0003
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0009 0.0125
Echinococcus granulosus fmrfamide receptor 0.0013 0.0008 0.0117
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0008 0.0117
Brugia malayi follicle stimulating hormone receptor 0.0013 0.0008 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.0184 0.3757
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0061 0.0926
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0016 0.0243
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0441
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.0008 0.0117
Toxoplasma gondii DNA methyltransferase 2, putative 0.0023 0.0022 0.0082
Brugia malayi Flap endonuclease-1 0.0031 0.0033 0.0045
Brugia malayi Dopamine receptor 0.0013 0.0008 0.0011
Schistosoma mansoni opsin-like receptor 0.0013 0.0008 0.0122
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0009 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0009 0.0178
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0023 0.0022 0.0341
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Brugia malayi Protein kinase domain containing protein 0.0015 0.0011 0.0015
Giardia lamblia DNA repair protein RAD52 0.0407 0.0554 0.2035
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0005 0.0064
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0048 0.0728
Toxoplasma gondii hypothetical protein 0.0057 0.0069 0.0254
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0005 0.0064
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0002 0.0039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0066
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0021 0.0028
Schistosoma mansoni ap endonuclease 0.0042 0.0048 0.0733
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0008 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0022 0.0325
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0008 0.0002 0.0007
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0033 0.0119
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0003 0.0048
Brugia malayi nuclear receptor RXR 0.0012 0.0006 0.0009
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0008 0.0002 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0059 0.0217
Leishmania major DNA polymerase eta, putative 0.0023 0.0022 0.0079
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0009 0.0178
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0008 0.0122
Onchocerca volvulus 0.001 0.0005 0.0003
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0005 0.0064
Mycobacterium ulcerans glutaminase 0.032 0.0434 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0.0008 0.0011
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0009 0.0178
Schistosoma mansoni biogenic amine (5HT) receptor 0.016 0.0212 0.3235
Schistosoma mansoni histamine h1 receptor 0.0013 0.0008 0.0122
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0021 0.0419
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0008 0.0163
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0009 0.0125
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0009 0.0013
Onchocerca volvulus 0.0013 0.0008 0.0006
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0002 0.0007
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0134
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0021 0.0314
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0006 0.0009
Echinococcus granulosus flap endonuclease 1 0.0031 0.0033 0.0492
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0134
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0064
Toxoplasma gondii RNA-directed DNA polymerase 0.1975 0.2724 1
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0008 0.0122
Echinococcus multilocularis allatostatin A receptor 0.0013 0.0008 0.0117
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0011 0.0163
Echinococcus granulosus g protein coupled receptor 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Brugia malayi putative neuropeptide receptor 0.0013 0.0008 0.0011
Entamoeba histolytica hypothetical protein 0.0042 0.0049 0.0846
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0016 0.0058
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0008 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Schistosoma mansoni biogenic amine receptor 0.0013 0.0008 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0021 0.0419
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0001 0.0000098982
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0009 0.0178
Echinococcus granulosus dna polymerase kappa 0.0023 0.0022 0.0325
Echinococcus granulosus sex peptide receptor 0.0013 0.0008 0.0117
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0008 0.0117
Echinococcus multilocularis traf and tnf receptor associated protein 0.0008 0.0002 0.0024
Onchocerca volvulus 0.0013 0.0008 0.0006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0048 0.0728
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0008 0.0002 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0021 0.0028
Brugia malayi hypothetical protein 0.0013 0.0008 0.0011
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0022 0.0079
Brugia malayi neuropeptide F receptor 0.0013 0.0008 0.0011
Echinococcus granulosus cpg binding protein 0.0075 0.0094 0.1431
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0008 0.0163
Plasmodium vivax DEAD/DEAH helicase, putative 0.0012 0.0007 0.0027
Brugia malayi Importin beta-1 subunit 0.0034 0.0037 0.0051
Echinococcus granulosus allatostatin A receptor 0.0013 0.0008 0.0117
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0168 0.0222 0.0816
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0012 0.0044
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0008 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0021 0.0028
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0002 0.0007
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0022 0.0479
Onchocerca volvulus 0.0013 0.0008 0.0006
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0021 0.0308
Echinococcus granulosus single minded 2 0.0038 0.0042 0.0641
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0008 0.0002 0.0007
Echinococcus granulosus traf and tnf receptor associated protein 0.0008 0.0002 0.0024
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0002 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0002 0.0024
Schistosoma mansoni lamin 0.0028 0.0029 0.0447
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0001 0.0000098982
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0005 0.0064
Brugia malayi G-protein coupled receptor 0.0013 0.0008 0.0011
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0022 0.0479
Onchocerca volvulus 0.0013 0.0008 0.0006
Loa Loa (eye worm) BRM protein 0.0041 0.0047 0.0952
Loa Loa (eye worm) glutaminase 2 0.032 0.0434 0.8858
Brugia malayi Nuclear hormone receptor E75 0.001 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus multilocularis geminin 0.0199 0.0265 0.4052
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0021 0.0419
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0008 0.0122
Brugia malayi sulfakinin receptor protein 0.0013 0.0008 0.0011
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0.0008 0.0011
Echinococcus multilocularis disco interacting protein 2 0.0045 0.0053 0.0802
Echinococcus multilocularis cpg binding protein 0.0075 0.0094 0.1431
Brugia malayi Nuclear hormone receptor E75 0.001 0.0005 0.0006
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0008 0.0002 0.0029
Schistosoma mansoni hypothetical protein 0.0199 0.0265 0.4056
Leishmania major hypothetical protein, conserved 0.0008 0.0002 0.0007
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0003 0.0053
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0008 0.0002 0.0007
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0116 0.0151 0.2694
Schistosoma mansoni cript-related 0.0008 0.0002 0.0029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0021 0.0308
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0009 0.0178
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0002 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0008 0.0122
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0093
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0008 0.0117
Schistosoma mansoni zinc finger protein 0.001 0.0005 0.007
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.0208 0.4243
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0023 0.0022 0.0369
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0048 0.1868
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0022 0.003
Echinococcus granulosus orexin receptor type 2 0.0013 0.0008 0.0117
Echinococcus multilocularis neutral sphingomyelinase 0.0008 0.0002 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus granulosus death domain containing protein 0.0015 0.0011 0.0163
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0013 0.0008 0.0163
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0419
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0008 0.0163
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0009 0.0031
Schistosoma mansoni amine GPCR 0.0013 0.0008 0.0122
Echinococcus multilocularis BRK domain containing protein 0.0014 0.0009 0.0134
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0021 0.0314
Plasmodium vivax importin-beta 2, putative 0.0034 0.0037 0.0136
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0009 0.0178
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1975 0.2724 1
Schistosoma mansoni amine GPCR 0.0013 0.0008 0.0122
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.0008 0.0122
Schistosoma mansoni synaptojanin 0.0008 0.0002 0.0029
Brugia malayi nuclear receptor NHR-67 0.001 0.0005 0.0006
Echinococcus multilocularis Smad4 0.001 0.0003 0.0048
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0016 0.0058
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0023
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0023 0.0022 0.0082
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0049 0.0744
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0021 0.0028
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.0008 0.0122
Echinococcus multilocularis muscleblind protein 0.0175 0.0233 0.3554
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0016 0.0058
Leishmania major mitochondrial DNA polymerase beta 0.0354 0.048 0.1763
Echinococcus multilocularis snurportin 1 0.0361 0.049 0.7488
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0008 0.0002 0.0007
Plasmodium vivax exodeoxyribonuclease III, putative 0.0008 0.0002 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0049 0.0739
Onchocerca volvulus 0.0013 0.0008 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0022 0.0079
Trichomonas vaginalis glutaminase, putative 0.032 0.0434 1
Schistosoma mansoni neuropeptide receptor 0.0013 0.0008 0.0122
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0002 0.0007
Schistosoma mansoni coup transcription factor 0.0022 0.0021 0.0314
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0059 0.0217
Leishmania major RNA-editing complex protein MP100, putative 0.0008 0.0002 0.0007
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0583
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0008 0.0117
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0013 0.0008 0.0163
Schistosoma mansoni intermediate filament proteins 0.0028 0.0029 0.0447
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0008 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Echinococcus multilocularis deoxyribonuclease 1 2 0.0008 0.0002 0.0024
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0016 0.0058
Echinococcus granulosus muscleblind protein 0.0175 0.0233 0.3554
Schistosoma mansoni opsin-like receptor 0.0013 0.0008 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0021 0.0308
Brugia malayi RNA, U transporter 1 0.0096 0.0123 0.017
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0171
Echinococcus granulosus DNA methyltransferase 2, putative 0.0023 0.0022 0.0336
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0006 0.009
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0059 0.0217
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0008 0.0117
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0163
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0016 0.0058
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0016 0.0058
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0008 0.0002 0.0024

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -5.31 Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement ChEMBL. 8568799
Ki (binding) = -5.3 Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement ChEMBL. 8568799
Log Ki (binding) = 5.3 Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement ChEMBL. 8568799
Log Ki (binding) = 5.31 Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement ChEMBL. 8568799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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