Detailed information for compound 402354

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1380.51 | Formula: C67H85N19O14
  • H donors: 18 H acceptors: 16 LogP: -2.31 Rotable bonds: 45
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)NCC(=O)N)CCCN=C(N)N)CC(C)C)Cc1[nH]c2c(n1)c1ccccc1cc2)Cc1ccc(cc1)O)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)N)Cc1nc[nH]c1
  • InChi: 1S/C67H85N19O14/c1-35(2)25-47(59(93)78-46(13-7-23-73-67(70)71)66(100)86-24-8-14-53(86)65(99)75-32-54(69)89)80-63(97)51(29-55-77-45-21-17-37-9-3-4-11-42(37)57(45)85-55)83-60(94)48(26-36-15-18-40(88)19-16-36)81-64(98)52(33-87)84-61(95)49(27-38-30-74-44-12-6-5-10-41(38)44)82-62(96)50(28-39-31-72-34-76-39)79-58(92)43(68)20-22-56(90)91/h3-6,9-12,15-19,21,30-31,34-35,43,46-53,74,87-88H,7-8,13-14,20,22-29,32-33,68H2,1-2H3,(H2,69,89)(H,72,76)(H,75,99)(H,77,85)(H,78,93)(H,79,92)(H,80,97)(H,81,98)(H,82,96)(H,83,94)(H,84,95)(H,90,91)(H4,70,71,73)/t43-,46-,47-,48-,49-,50-,51-,52-,53+/m0/s1
  • InChiKey: DPDIEEFYNMXANJ-YNIDJBIZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0029 0.0057 0.0092
Loa Loa (eye worm) hypothetical protein 0.0049 0.0131 0.021
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0175 0.046
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0077 0.0235 0.1627
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0811 0.301 1
Echinococcus multilocularis casein kinase ii subunit beta 0.0036 0.0083 0.0083
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0041 0.0169
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0565 0.2081 0.3339
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0041 0.0061
Echinococcus granulosus protein kinase shaggy 0.0059 0.0168 0.0168
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.049 0.1606
Leishmania major oxidoreductase-like protein 0.0025 0.0041 0.0061
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Echinococcus granulosus endothelin converting enzyme 1 0.0091 0.0291 0.0291
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2661 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0165 0.0569 0.1245
Echinococcus granulosus lamin 0.0026 0.0046 0.0046
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0304 0.1095 0.3663
Schistosoma mansoni hypothetical protein 0.0095 0.0306 0.067
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0041 0.0169
Echinococcus granulosus tyrosine protein kinase Lyn 0.0021 0.0027 0.0027
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0235 0.0235
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0353 0.2515
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0083 0.0484
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0379 0.1228
Entamoeba histolytica protein kinase domain containing protein 0.0144 0.049 0.1606
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0018 0.0039
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0198 0.0695 0.1839
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0018 0.0018
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0304 0.1095 0.1757
Entamoeba histolytica hypothetical protein 0.0036 0.0081 0.0214
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0066 0.0066
Echinococcus multilocularis beta adrenergic receptor kinase 0.0031 0.0062 0.0062
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0797 0.2958 0.8674
Entamoeba histolytica protein kinase rad3, putative 0.0174 0.0604 0.1993
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0177 0.0615 0.0987
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0235 0.0235
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0353 0.0909
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0168 0.0155
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0036 0.0083 0.0065
Loa Loa (eye worm) hypothetical protein 0.0091 0.0291 0.0466
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0165 0.0569 0.0557
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0115 0.0379 0.0379
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0304 0.1095 0.7968
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0018 0.0018
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0218 0.0771 0.5565
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0797 0.2958 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0041 0.0102 0.0245
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0057 0.0125
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0025 0.0041 0.0167
Schistosoma mansoni lamin 0.0026 0.0046 0.0101
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0056 0.0158 0.0254
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0018 0.0018
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0056 0.0158 0.0158
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0077 0.0235 0.0639
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.0937 0.3125
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0083 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0377 0.137 0.4597
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0353 0.114
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0168 0.0369
Brugia malayi Protein kinase domain containing protein 0.1664 0.6233 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0189 0.0659 0.1443
Brugia malayi peptidase family M13 containing protein 0.0022 0.003 0.0048
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0056 0.0158 0.0141
Loa Loa (eye worm) phosphatidylinositol kinase 0.0077 0.0235 0.0377
Schistosoma mansoni protein kinase 0.0144 0.049 0.1074
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0083 0.0222
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0165 0.0569 0.056
Trypanosoma brucei polo-like protein kinase 0.0198 0.0695 0.5006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0057 0.0125
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0306 0.0491
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0168 0.0715
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0056 0.013
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Giardia lamblia Kinase, PLK 0.0198 0.0695 0.4074
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0046 0.0074
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0165 0.0569 0.1622
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0056 0.0158 0.0158
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.0175 0.0382
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0056 0.0038
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Schistosoma mansoni hypothetical protein 0.0115 0.0379 0.083
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1222 0.4565 0.4565
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0041 0.0169
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0289 0.1037 0.7538
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0168 0.0407
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0018 0.0039
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0041 0.0169
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0066 0.0066
Schistosoma mansoni neprilysin 0.0024 0.0036 0.0079
Trypanosoma cruzi polo-like protein kinase, putative 0.0198 0.0695 0.1996
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0056 0.013
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0018 0.0029
Schistosoma mansoni protein kinase 0.0056 0.0158 0.0347
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0028
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0371 0.1348 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0046 0.0074
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0175 0.1154
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0071
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0235 0.0377
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.049 0.1606
Leishmania major phosphatidylinositol kinase, putative 0.0077 0.0235 0.0589
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0056 0.0158 0.0158
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0057 0.0057
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0056 0.0158 0.0141
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0353 0.114
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0056 0.0041
Loa Loa (eye worm) hypothetical protein 0.01 0.0323 0.0517
Trypanosoma brucei Casein kinase II 0.0144 0.049 0.3489
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0056 0.028
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0141 0.0478 0.0767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.1165 0.3902
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0062 0.0136
Loa Loa (eye worm) RecQ helicase 0.0021 0.0025 0.004
Loa Loa (eye worm) zinc metallopeptidase 4 0.0022 0.003 0.0048
Brugia malayi SH2 domain containing protein 0.0665 0.246 0.3946
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0168 0.0715
Loa Loa (eye worm) hypothetical protein 0.0069 0.0207 0.0331
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0041 0.0169
Brugia malayi hypothetical protein 0.0162 0.0557 0.0894
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0174 0.0604 0.0969
Echinococcus granulosus survival motor neuron protein 1 0.0467 0.1709 0.1709
Leishmania major phosphatidylinositol kinase related protein, putative 0.0091 0.029 0.0738
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0444 0.1625 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0018 0.0039
Trypanosoma cruzi target of rapamycin kinase 3 0.035 0.1268 0.3685
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0377 0.137 0.137
Schistosoma mansoni voltage-gated cation channel 0.0032 0.0066 0.0145
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0086 0.0271 0.0593
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0077 0.0235 0.1627
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0077 0.0235 0.0222
Toxoplasma gondii ck2 beta subunit 0.0036 0.0083 0.0065
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Brugia malayi Casein kinase II, alpha chain 0.0144 0.049 0.0786
Onchocerca volvulus 0.0077 0.0235 0.0721
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0037 0.0055
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0025 0.0041
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0025 0.0041 0.0041
Echinococcus multilocularis serine protein kinase ATM 0.0189 0.0659 0.0659
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0041 0.0167
Echinococcus granulosus geminin 0.0166 0.0575 0.0575
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0056 0.0158 0.0253
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0018 0.0018
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0041 0.0169
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0077 0.0235 0.1603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.1241 0.4161
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0053 0.0053
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0201 0.0322
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0165 0.0569 0.1495
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0056 0.0158 0.0158
Echinococcus granulosus calcium dependent protein kinase 0.0045 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0147 0.0437
Loa Loa (eye worm) hypothetical protein 0.0069 0.0207 0.0331
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0083 0.0222
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0083 0.0068
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0235 0.0219
Brugia malayi M-phase phosphoprotein, mpp8 0.0099 0.0322 0.0517
Schistosoma mansoni casein kinase II beta subunit 0.0036 0.0083 0.0183
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0169 0.0586 0.0586
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0147 0.0437
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0081 0.013
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0658 0.2432 0.8209
Trypanosoma cruzi hypothetical protein, conserved 0.0916 0.3408 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0235 0.0219
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0025 0.0041 0.0079
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0025 0.0041 0.0023
Echinococcus granulosus intermediate filament protein 0.0026 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.1139 0.3814
Plasmodium vivax unspecified product 0.0144 0.049 0.3544
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0018 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.1139 0.3814
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0168 0.0168
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0175 0.0533
Echinococcus multilocularis casein kinase ii subunit alpha 0.0144 0.049 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0019 0.0003
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0083 0.0068
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0377 0.137 0.3673
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0067 0.0201 0.0322
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0088 0.028 0.028
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0041 0.0169
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0371 0.1348 0.1348
Onchocerca volvulus 0.0049 0.0131 0.0374
Trypanosoma brucei pteridine reductase 1 0.0025 0.0041 0.0166
Entamoeba histolytica casein kinase, putative 0.0144 0.049 0.1606
Leishmania major protein kinase, putative 0.0056 0.0158 0.038
Echinococcus granulosus cyclin dependent kinase 19 0.0141 0.0478 0.0478
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0353 0.0987
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0165 0.0569 0.407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.1037 0.3466
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0041 0.0167
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0198 0.0695 0.0695
Loa Loa (eye worm) hypothetical protein 0.0069 0.0207 0.0331
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0019 0.0029
Schistosoma mansoni survival motor neuron protein 0.0095 0.0306 0.067
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0338 0.1088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0185 0.0644 0.213
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0377 0.137 0.2198
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0 0.0001
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0009 0.0019
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.035 0.1268 0.3396
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0032 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0077 0.0235 0.0377
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.1664 0.6233 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0018 0.0039
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0351 0.1274 0.279
Echinococcus multilocularis voltage dependent calcium channel 0.0032 0.0066 0.0066
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0077 0.0235 0.0515
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.049 0.1606
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0165 0.0569 0.1872
Echinococcus multilocularis endothelin converting enzyme 1 0.0091 0.0291 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.0811 0.301 0.6593
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.035 0.1267 0.4249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.1139 0.3814
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0131 0.044 0.3116
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0025 0.0041 0.0065
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0177 0.0615 0.0987
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0056 0.0158 0.0158
Onchocerca volvulus 0.0077 0.0235 0.0721
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0077 0.0235 0.1627
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0018 0.0018
Brugia malayi Cytochrome P450 family protein 0.0019 0.0019 0.003
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0563 0.2073 0.2073
Loa Loa (eye worm) hypothetical protein 0.0069 0.0207 0.0331
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0339 0.1225 0.1225
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0304 0.1095 0.3663
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.049 0.1606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0252 0.0898 0.2994
Schistosoma mansoni endothelin-converting enzyme-related 0.0022 0.003 0.0066
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0083 0.0213
Giardia lamblia Casein kinase II beta chain 0.0036 0.0083 0.0173
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0563 0.2073 0.2073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0189 0.0659 0.1057
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.049 0.1606
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0304 0.1095 0.3176
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0025 0.0041 0.0167
Echinococcus granulosus serine protein kinase ATM 0.0189 0.0659 0.0659
Echinococcus granulosus high voltage activated calcium channel beta 0.0086 0.0271 0.0271
Onchocerca volvulus 0.0041 0.0099 0.0267
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.0695 0.2303
Entamoeba histolytica protein kinase, putative 0.0021 0.0027 0.0032
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0811 0.301 0.301
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.012 0.0263
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0077 0.0235 0.0739
Schistosoma mansoni dihydropteridine reductase 0.0025 0.0041 0.009
Plasmodium falciparum casein kinase 2, alpha subunit 0.0144 0.049 0.0481
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.0695 0.2303
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0056 0.0114
Plasmodium falciparum calcium-dependent protein kinase 2 0.0056 0.0158 0.0145
Loa Loa (eye worm) phosphatidylinositol 3 0.0228 0.0806 0.1293
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Loa Loa (eye worm) Csnk2b protein 0.0036 0.0083 0.0133
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0235 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.0695 0.1523
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0797 0.2958 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0165 0.0569 0.1622
Brugia malayi Cytochrome P450 family protein 0.0019 0.0019 0.003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0797 0.2958 0.4747
Echinococcus multilocularis tumor protein p63 0.0335 0.1211 0.1211
Echinococcus multilocularis survival motor neuron protein 1 0.0467 0.1709 0.1709
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0371 0.1348 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0041 0.0169
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0025 0.0041 0.0169
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0304 0.1095 0.3663
Onchocerca volvulus 0.0045 0.0117 0.0326
Echinococcus multilocularis cyclin dependent kinase 19 0.0141 0.0478 0.0478
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0371 0.1348 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.1165 0.3902
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0056 0.028
Plasmodium falciparum calcium-dependent protein kinase 5 0.0056 0.0158 0.0145
Brugia malayi hypoxia-induced factor 1 0.0149 0.051 0.0818
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0353 0.114
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0019 0.0029
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0235 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0315 0.1011
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0353 0.114
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0025 0.0041 0.009
Plasmodium falciparum enoyl-acyl carrier reductase 0.0371 0.1348 0.1351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.0337 0.1086
Trypanosoma brucei oxidoreductase-like protein 0.0025 0.0041 0.0166
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0077 0.0235 0.0739
Loa Loa (eye worm) hypothetical protein 0.0067 0.0201 0.0322
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0056 0.0158 0.1049
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0018 0.0018
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0025 0.0041 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0235 0.0834 0.2776
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0025 0.0041 0.0167
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0168 0.0168
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0019 0.0002
Loa Loa (eye worm) hypothetical protein 0.0112 0.037 0.0593
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0377 0.137 0.4597
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0056 0.013
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0158 0.0477
Mycobacterium ulcerans oxidoreductase 0.0025 0.0041 0.0169
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.0175 0.0175
Leishmania major hypothetical protein, unknown function 0.0077 0.0235 0.0589
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0222 0.0222
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0057 0.0091
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0377 0.137 0.137
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0811 0.301 0.4829
Onchocerca volvulus 0.0233 0.0826 0.2697
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0339 0.1225 0.1966
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0079
Brugia malayi intracellular kinase 0.0059 0.0168 0.027
Echinococcus granulosus casein kinase ii subunit beta 0.0036 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0162 0.0557 0.0893
Echinococcus multilocularis high voltage activated calcium channel beta 0.0086 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.0075
Toxoplasma gondii hypothetical protein 0.0053 0.0147 0.0129
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0018 0.0039
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0047 0.0099
Echinococcus granulosus expressed conserved protein 0.016 0.0549 0.0549
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0165 0.0569 0.4134
Entamoeba histolytica hypothetical protein 0.0077 0.0235 0.0739
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0047 0.0099
Onchocerca volvulus 0.0099 0.0322 0.1012
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Entamoeba histolytica hypothetical protein 0.0036 0.0081 0.0214
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0077 0.0235 0.0739
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0077 0.0235 0.0639
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1222 0.4565 0.4565
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0056 0.0158 0.0253
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0018 0.0029
Schistosoma mansoni kinase 0.0106 0.0347 0.0761
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0191 0.0668 0.0658
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0041 0.0169
Leishmania major protein kinase, putative 0.0024 0.0037 0.0051
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.012 0.0263
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.0175 0.0533
Toxoplasma gondii peptidase family M13 protein 0.0091 0.0291 0.0276
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0025 0.0025
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0056 0.0158 0.0158
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0018 0.0018
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.012 0.0263
Brugia malayi Protein kinase domain containing protein 0.0811 0.301 0.4829
Brugia malayi FAT domain containing protein 0.0115 0.0379 0.0608
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0056 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0056 0.0158 0.0253
Loa Loa (eye worm) hypothetical protein 0.0091 0.0291 0.0466
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0041 0.0102 0.0285
Entamoeba histolytica protein kinase, putative 0.0057 0.0162 0.0489
Loa Loa (eye worm) hypothetical protein 0.0069 0.0207 0.0331
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0077 0.0235 0.0639
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0235 0.1627
Schistosoma mansoni hypothetical protein 0.016 0.0549 0.1203
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0018 0.0039
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0041 0.0169
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0066 0.0066
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0353 0.0773
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0353 0.114
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0169 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0077
Brugia malayi Csnk2b protein 0.0036 0.0083 0.0134
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0041 0.0169
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0721 0.2669 0.9017
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0018 0.0028
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0056 0.0158 0.0158
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0831 0.1333
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0377 0.137 0.3986
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0025 0.0041 0.0169
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0235 0.0739
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0028
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0025 0.0041 0.0061
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0584 0.2151 0.7254
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0425 0.1553 0.2491
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0175 0.0533
Schistosoma mansoni hypothetical protein 0.0051 0.0138 0.0303
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0088 0.028 0.028
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0144 0.049 0.0786
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0019 0.0002
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0018 0.0039
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0339 0.1225 0.356
Mycobacterium tuberculosis Conserved hypothetical protein 0.0077 0.0235 0.1627
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0081 0.0468
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0047 0.0103
Echinococcus multilocularis expressed protein 0.037 0.1344 0.1344
Plasmodium falciparum calcium-dependent protein kinase 3 0.0056 0.0158 0.0145
Leishmania major phosphatidylinositol 3-kinase, putative 0.0289 0.1037 0.2768
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0047 0.0075
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0168 0.1123
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0175 0.0533
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0041 0.0066
Loa Loa (eye worm) hypothetical protein 0.0279 0.1002 0.1607
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0165 0.0569 0.1872
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0377 0.137 0.4597
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0056 0.013
Echinococcus multilocularis 0.0077 0.0235 0.0235
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0353 0.0353
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0079
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0041 0.0066
Brugia malayi Pre-SET motif family protein 0.0029 0.0057 0.0091
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0377 0.137 0.3986
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0719 0.1152
Loa Loa (eye worm) phosphatidylinositol 3 0.0299 0.1077 0.1728
Trichomonas vaginalis PIKK family atypical protein kinase 0.0377 0.137 0.4597
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0079
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0131 0.0288
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0377 0.137 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.012 0.0263
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0032 0.0066 0.0066
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0797 0.2958 0.8674
Onchocerca volvulus 0.0026 0.0046 0.0089
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0032 0.0066 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.0809 0.2689
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.049 0.1606
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0353 0.114
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0083 0.0213
Leishmania major phosphatidylinositol 3-kinase, putative 0.0165 0.0569 0.1495
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0041 0.0066
Toxoplasma gondii target of rapamycin (TOR), putative 0.0343 0.1241 0.1239
Trichomonas vaginalis PIKK family atypical protein kinase 0.035 0.1267 0.4249
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0077 0.0235 0.0235
Echinococcus multilocularis lamin dm0 0.0026 0.0046 0.0046
Brugia malayi hypothetical protein 0.0036 0.0081 0.013
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0803 0.2982 0.2982
Brugia malayi Pre-SET motif family protein 0.0204 0.0719 0.1153
Brugia malayi 6-phosphofructokinase 0.0108 0.0353 0.0567
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Schistosoma mansoni hypothetical protein 0.0166 0.0575 0.126
Brugia malayi Protein kinase domain containing protein 0.0141 0.0478 0.0767
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0018 0.0039
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0378 0.1376 0.4618
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0353 0.0566
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0168 0.0269
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0057 0.0125
Loa Loa (eye worm) hypothetical protein 0.0467 0.1709 0.2742
Brugia malayi 6-phosphofructokinase 0.0108 0.0353 0.0567
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0018 0.0018
Trypanosoma brucei target of rapamycin kinase 3, putative 0.035 0.1268 0.9245
Echinococcus multilocularis geminin 0.0166 0.0575 0.0575
Giardia lamblia Hypothetical protein 0.0077 0.0235 0.1142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.0809 0.2689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.1037 0.3466
Brugia malayi serine/threonine-protein kinase plk-2 0.0198 0.0695 0.1115
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0018 0.0039
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0198 0.0695 0.1114
Echinococcus granulosus expressed protein 0.037 0.1344 0.1344
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0377 0.137 0.3673
Echinococcus multilocularis calcium dependent protein kinase 0.0045 0.0114 0.0114
Brugia malayi phosphofructokinase 0.0108 0.0353 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0191 0.0668 0.2211
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0584 0.2151 0.7254
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0041 0.0102 0.0285
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0019 0.002 0.002
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0018 0.0018
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0056 0.0158 0.1033
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0175 0.046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.003
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0222 0.0222
Toxoplasma gondii protein kinase, putative 0.263 0.9884 1
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0022 0.003 0.0066
Plasmodium vivax hypothetical protein 0.0077 0.0235 0.1627
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0056 0.013
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0025 0.0025
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0353 0.0566
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0062 0.0136
Schistosoma mansoni MAGUK homolog 0.0019 0.002 0.0043
Onchocerca volvulus 0.0025 0.0041 0.0072
Loa Loa (eye worm) phosphatidylinositol 3 0.0377 0.137 0.2197
Plasmodium falciparum calcium-dependent protein kinase 1 0.0056 0.0158 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0478 0.1048
Loa Loa (eye worm) hypothetical protein 0.0115 0.0379 0.0607
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0047 0.0047
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0032 0.0066 0.0106
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0047 0.0047
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0091 0.029 0.0801
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0175 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.1241 0.4161
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0077 0.0235 0.0515
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0056 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0235 0.1627
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0031 0.0062 0.0099
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0201 0.0322
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0168 0.0151
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.0065
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0304 0.1095 0.3663
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0083 0.0222
Echinococcus granulosus single minded 2 0.0036 0.0081 0.0081
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0168 0.0511
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0056 0.0158 0.1049
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Loa Loa (eye worm) hypothetical protein 0.0191 0.0668 0.1071
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0079
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0025 0.0041 0.0023
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Echinococcus multilocularis lamin 0.0026 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0077 0.0235 0.0739
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0077 0.0235 0.1603
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0228 0.0806 0.2323
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0024 0.0037 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.1241 0.4161
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0299 0.1077 0.2878
Echinococcus multilocularis expressed conserved protein 0.016 0.0549 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0299 0.1077 0.3602
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0031 0.0062 0.0099
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0144 0.049 0.3544
Trichomonas vaginalis PIKK family atypical protein kinase 0.035 0.1267 0.4249
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0041 0.0061
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0056 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0174 0.0604 0.1993
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0018 0.0018
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0797 0.2958 1
Onchocerca volvulus 0.0059 0.0168 0.0497
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0079
Brugia malayi Peptidase family M13 containing protein 0.0091 0.0291 0.0467
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0185 0.0644 0.213
Brugia malayi Cam kinase protein 1 0.0056 0.0158 0.0254
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0291 0.0637
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0018 0.0029
Leishmania major hypothetical protein, conserved 0.0993 0.3697 1
Schistosoma mansoni hypothetical protein 0.0024 0.0036 0.0079
Echinococcus granulosus voltage dependent calcium channel 0.0032 0.0066 0.0066
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0168 0.0511
Onchocerca volvulus 0.0026 0.0046 0.0089
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0041 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.1139 0.3812
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0174 0.0604 0.0604
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0371 0.1348 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0353 1
Trichomonas vaginalis hypothetical protein 0.0371 0.1348 0.4525
Mycobacterium ulcerans zinc metalloprotease 0.0091 0.0291 0.2047
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0018 0.0018
Brugia malayi hypothetical protein 0.0019 0.0018 0.0029
Onchocerca volvulus 0.0036 0.0081 0.0205
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0083 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.1241 0.4161
Brugia malayi Angiotensin-converting enzyme family protein 0.0599 0.2209 0.3544
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0599 0.2209 0.3544
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0165 0.0569 0.0912
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0165 0.0569 0.0557
Entamoeba histolytica protein kinase, putative 0.0059 0.0168 0.0511
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0056 0.013
Schistosoma mansoni protein kinase 0.0056 0.0158 0.0347
Trypanosoma cruzi polo-like protein kinase, putative 0.0198 0.0695 0.1996
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0797 0.2958 1
Schistosoma mansoni single-minded 0.0048 0.0128 0.0281
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0216 0.0762 0.4499
Onchocerca volvulus Serine\/threonine kinase homolog 0.0198 0.0695 0.2259
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0158 0.0347
Loa Loa (eye worm) hypothetical protein 0.0069 0.0207 0.0331
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0174 0.0604 0.1727
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0081 0.0081
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.003 0.0066
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0658 0.2432 0.8209
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0165 0.0569 0.0569
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0353 0.0773
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0037 0.0055
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0031 0.0062 0.0099
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0099 0.0218
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0371 0.1348 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0018 0.0018
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0025 0.0041 0.0167
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0025 0.0041 0.0066
Brugia malayi PXA domain containing protein 0.002 0.0023 0.0037
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0175 0.046
Brugia malayi hypothetical protein 0.0019 0.0018 0.0029
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0175 0.0533
Echinococcus granulosus casein kinase ii subunit alpha 0.0144 0.049 0.049
Mycobacterium tuberculosis Probable oxidoreductase 0.0025 0.0041 0.0167
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0165 0.0569 0.1872
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.028 0.0613
Echinococcus multilocularis Zinc finger, PHD finger 0.0165 0.0569 0.0569
Schistosoma mansoni protein kinase 0.0056 0.0158 0.0347
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0112 0.037 0.1036
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0115 0.0379 0.0379
Loa Loa (eye worm) gastrulation defective protein 1 0.0129 0.0434 0.0696
Trichomonas vaginalis PIKK family atypical protein kinase 0.035 0.1267 0.4249
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0025 0.0041 0.0167
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0377 0.137 0.4597
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0025 0.0025
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0077 0.0235 0.0639
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0353 0.0566
Loa Loa (eye worm) hypothetical protein 0.0029 0.0057 0.0091
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0018 0.0018
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0018 0.0039
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0032 0.0066 0.0145
Schistosoma mansoni lamin 0.0026 0.0046 0.0101
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0339 0.1225 0.1225
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0018 0.0018
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0175 0.0533
Brugia malayi Protein kinase domain containing protein 0.0026 0.0044 0.007
Leishmania major pteridine reductase 1 0.0025 0.0041 0.0061
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0083 0.0484
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0047 0.0125 0.02
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0025 0.0041 0.0167
Loa Loa (eye worm) hypothetical protein 0.0174 0.0604 0.0969
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0235 0.0377
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0025 0.0041 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0062 0.0136
Plasmodium falciparum calcium-dependent protein kinase 4 0.0056 0.0158 0.0145
Trypanosoma cruzi casein kinase II, putative 0.0144 0.049 0.1391
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0041 0.0169
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0019 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0665 0.246 0.3946
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0018 0.0029
Brugia malayi hypothetical protein 0.0467 0.1709 0.2742
Loa Loa (eye worm) retinol dehydrogenase 12 0.0025 0.0041 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.1037 0.3466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.1139 0.3812
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0168 0.0269
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0353 0.0353
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0165 0.0569 0.0569
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.049 0.1606
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0147 0.0437
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.0315 0.1011
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0023 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.1139 0.3814
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0041 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.1241 0.4161
Entamoeba histolytica serine/threonine protein kinase, putative 0.0198 0.0695 0.2303
Loa Loa (eye worm) hypothetical protein 0.0067 0.0201 0.0322
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0024 0.0037 0.0055
Brugia malayi Serotonin receptor 0.0462 0.1692 0.2715
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0165 0.0569 0.1872
Echinococcus granulosus tumor protein p63 0.0335 0.1211 0.1211
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0036 0.0083 0.0176
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0175 0.0533
Brugia malayi PXA domain containing protein 0.002 0.0023 0.0037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0041 0.0169
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0083 0.0222
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0046 0.0074
Brugia malayi intermediate filament protein 0.0026 0.0046 0.0074
Leishmania major protein kinase, putative 0.0024 0.0037 0.0051
Schistosoma mansoni fkbp-rapamycin associated protein 0.0174 0.0604 0.1323
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0198 0.0695 0.0695
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1222 0.4565 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0377 0.137 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.0809 0.2689
Giardia lamblia Phosphatidylinositol 4-kinase 0.0077 0.0235 0.1142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.1241 0.4161
Echinococcus granulosus lamin dm0 0.0026 0.0046 0.0046
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0081 0.0177
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0235 0.0377
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0041 0.0167
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0056 0.0041
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0168 0.0511
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0041 0.0169
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0014
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0175 0.0533
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0022 0.003 0.0066
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0056 0.0038
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0091 0.0291 0.2045
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0165 0.0569 0.0569
Brugia malayi hypothetical protein 0.01 0.0323 0.0518
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0339 0.1225 0.2684
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0047 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0028
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0077 0.0235 0.0235
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0371 0.1348 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0322 0.0516
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0235 0.0377
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0036 0.0083 0.0478
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0032 0.0066 0.0145
Loa Loa (eye worm) hypothetical protein 0.0563 0.2073 0.3325
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0025 0.0041 0.0026
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0175 0.0533
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0019 0.0029
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.003 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0235 0.0739
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0175 0.0533
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0831 0.1333
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0056 0.0114
Trypanosoma brucei protein kinase, putative 0.0059 0.0168 0.1107
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0128 0.0281
Schistosoma mansoni intermediate filament proteins 0.0026 0.0046 0.0101
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0175 0.1154
Plasmodium falciparum protein kinase 7 0.263 0.9884 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0353 0.2475
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.0695 0.2303
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0047 0.0099
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0353 0.2513
Loa Loa (eye worm) calcium channel 0.0032 0.0066 0.0105
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Loa Loa (eye worm) hypothetical protein 0.0045 0.0117 0.0187
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0018 0.0018
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0377 0.137 0.3
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.0695 0.2303
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0057 0.0057
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0189 0.0659 0.4739
Leishmania major casein kinase II, putative 0.0144 0.049 0.1282
Toxoplasma gondii FATC domain-containing protein 0.0189 0.0659 0.0649
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0235 0.0377
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Mycobacterium leprae probable zinc metalloprotease 0.0091 0.0291 0.2045
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0019 0.0002
Onchocerca volvulus 0.0095 0.0306 0.0957
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0056 0.0158 0.1049
Toxoplasma gondii CMGC kinase, CK2 family 0.0144 0.049 0.0478
Onchocerca volvulus 0.0099 0.0322 0.1012
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Loa Loa (eye worm) oxidoreductase 0.0025 0.0041 0.0065
Schistosoma mansoni hypothetical protein 0.0077 0.0235 0.0515
Leishmania major phosphatidylinositol 4-kinase, putative 0.0077 0.0235 0.0589
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0056 0.013
Entamoeba histolytica hypothetical protein 0.0036 0.0081 0.0214
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.0695 0.2303
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0353 0.2513
Plasmodium vivax calcium-dependent protein kinase, putative 0.0056 0.0158 0.1049
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0041 0.0167
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0165 0.0569 0.1872
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0056 0.0158 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.1139 0.3812
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0021 0.0027 0.0032
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0067 0.0201 0.0322
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0018 0.0029
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0339 0.1225 0.356
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0353 0.114
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.003 0.0066
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0032 0.0066 0.0066
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0165 0.0569 0.1245
Trichomonas vaginalis PIKK family atypical protein kinase 0.035 0.1267 0.4249
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0036 0.0079
Schistosoma mansoni hypothetical protein 0.0166 0.0575 0.126
Echinococcus granulosus beta-adrenergic receptor kinase 0.0031 0.0062 0.0062
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0174 0.0604 0.0604
Giardia lamblia GTOR 0.0377 0.137 0.8375
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0168 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.0338 0.1088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0659 0.218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0289 0.1037 0.3466
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.0695 0.2303
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0025 0.0041 0.0023
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0299 0.1077 0.7835
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0077 0.0235 0.0219
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.012 0.0263
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0028
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0041 0.0169
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0057 0.0039
Loa Loa (eye worm) phosphatidylinositol 3 0.1083 0.4038 0.6479
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0032 0.0066 0.0066
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.028 0.0613
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0175 0.0533
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0235 0.0377
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0105
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0168 0.0441
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0349 0.1265 0.4241
Giardia lamblia Kinase, CMGC CK2 0.0144 0.049 0.2767
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0811 0.301 0.4828
Echinococcus multilocularis musashi 0.0026 0.0046 0.0046
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0165 0.0569 0.0912
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0077 0.0235 0.0222
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0019 0.0003
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0175 0.0533
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0189 0.0659 0.1889
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0811 0.301 0.301
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0825 0.2746
Schistosoma mansoni hypothetical protein 0.0036 0.0081 0.0177
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0091 0.0291 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.1241 0.4161
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0081 0.0081
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0041 0.0169
Loa Loa (eye worm) hypothetical protein 0.0091 0.0291 0.0466
Brugia malayi PAS domain containing protein 0.0048 0.0128 0.0206
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.0695 0.2303
Echinococcus granulosus bloom syndrome protein 0.0021 0.0025 0.0025
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0077 0.0235 0.0515
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0811 0.301 0.4828
Entamoeba histolytica hypothetical protein 0.0036 0.0081 0.0214
Plasmodium vivax SET domain protein, putative 0.0029 0.0057 0.0286
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.051 0.0817
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0168 0.0511
Onchocerca volvulus 0.0025 0.0041 0.0072
Entamoeba histolytica protein kinase, putative 0.0056 0.0158 0.0477
Entamoeba histolytica hypothetical protein 0.0189 0.0659 0.218
Entamoeba histolytica hypothetical protein 0.0077 0.0235 0.0739

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8 Antifertility effect of the compound was tested in adult female rats by estrus suppression assay ChEMBL. 6366232

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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