Detailed information for compound 450302

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 290.316 | Formula: C18H14N2O2
  • H donors: 2 H acceptors: 2 LogP: 3.73 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)N/N=C/c1c(O)ccc2c1cccc2
  • InChi: 1S/C18H14N2O2/c21-17-11-10-13-6-4-5-9-15(13)16(17)12-19-20-18(22)14-7-2-1-3-8-14/h1-12,21H,(H,20,22)/b19-12+
  • InChiKey: QQUWFXMXRVAVCX-XDHOZWIPSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus PHD finger protein rhinoceros 0.0045 0.0166 0.1217
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0613 0.0613
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0013 0.0023 0.0038
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0013 0.0023 0.0038
Schistosoma mansoni phd/f-box containing protein 0.0014 0.003 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0051 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0092 0.0092
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0613 0.0613
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0013 0.0093
Schistosoma mansoni smad 0.001 0.001 0.001
Loa Loa (eye worm) AGC/PKG protein kinase 0.0011 0.0014 0.0014
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0035 0.0124 0.0124
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0051 0.3156
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0155 0.0301
Echinococcus multilocularis PHD finger protein rhinoceros 0.0045 0.0166 0.1217
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0195 0.2013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0051 0.0051
Echinococcus granulosus dna polymerase eta 0.0015 0.0032 0.0233
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0062 0.0116
Brugia malayi jmjC domain containing protein 0.0014 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.002 0.002
Brugia malayi Cytochrome P450 family protein 0.0028 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0019 0.0051 0.0051
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0092 0.0092
Leishmania major DNA polymerase kappa, putative 0.0015 0.0032 0.1296
Toxoplasma gondii PHD-finger domain-containing protein 0.0015 0.0031 0.0055
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0013 0.0023 0.0038
Schistosoma mansoni jumonji/arid domain-containing protein 0.0055 0.0214 0.0214
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0003 0.0003
Mycobacterium leprae putative cytochrome p450 0.0013 0.0023 0.0038
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0003 0.0219
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1133 0.5048 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0195 0.1424
Loa Loa (eye worm) hypothetical protein 0.0077 0.031 0.031
Brugia malayi Smad1 0.001 0.001 0.001
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0236 0.0236
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0051 0.3306
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.002 0.015
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0094 0.018
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0062 0.3577
Leishmania major basic transcription factor 3a, putative 0.0042 0.0155 0.6924
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0032 0.0233
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0051 0.0375
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.002 0.015
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0051 0.0375
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0011 0.0014 0.0106
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0223 0.0223
Brugia malayi cytochrome P450 0.0013 0.0023 0.0023
Echinococcus multilocularis jumonji domain containing 1A 0.0014 0.003 0.0223
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0014
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0015 0.0031 0.0055
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0023 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013 0.0023 0.0038
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0014 0.003 0.0054
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0032 0.205
Brugia malayi jmjC domain containing protein 0.0055 0.0214 0.0214
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0015 0.0032 0.0329
Toxoplasma gondii PHD-finger domain-containing protein 0.0045 0.0166 0.0323
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.0223 0.1628
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0051 0.0095
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0014 0.0101
Brugia malayi beta-NAC-like protein 0.0042 0.0155 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0051 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.002 0.002
Schistosoma mansoni cpg binding protein 0.0022 0.0064 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013 0.0023 0.0038
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0094 0.018
Loa Loa (eye worm) jmjC domain-containing protein 0.0055 0.0214 0.0214
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0205 0.0884 0.0884
Echinococcus multilocularis peregrin 0.0045 0.0166 0.1217
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0094 0.0974
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0014 0.0145
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0014 0.003 0.1962
Loa Loa (eye worm) CYP4Cod1 0.0028 0.009 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0155 0.1604
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.001 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.0124 0.0905
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.002 0.015
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0014 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0094 0.018
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0013 0.0023 0.0881
Echinococcus multilocularis GPCR, family 2 0.0019 0.0051 0.0374
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Brugia malayi DIX domain containing protein 0.0011 0.0014 0.0014
Onchocerca volvulus 0.0028 0.0092 0.0966
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0032 0.205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.002 0.002
Echinococcus granulosus dnaJ subfamily B 0.0312 0.1367 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013 0.0023 0.0038
Echinococcus granulosus phd:f box containing protein 0.0014 0.003 0.0223
Echinococcus multilocularis smad 0.001 0.001 0.0071
Brugia malayi Cytochrome P450 family protein 0.0013 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Onchocerca volvulus 0.0011 0.0014 0.0145
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013 0.0023 0.0038
Toxoplasma gondii hypothetical protein 0.0011 0.0014 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0105
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0014 0.003 0.1782
Onchocerca volvulus 0.0008 0.0003 0.0036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.002 0.015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0032 0.205
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0013 0.0023 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013 0.0023 0.0038
Schistosoma mansoni cpg binding protein 0.0023 0.007 0.007
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0051 0.0051
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0013 0.0023 0.0038
Echinococcus multilocularis phd:f box containing protein 0.0014 0.003 0.0223
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.002 0.015
Schistosoma mansoni dishevelled 0.0011 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0045 0.0166 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0124 0.0124
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0223 0.0967 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.0223 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Echinococcus multilocularis expressed conserved protein 0.0112 0.0467 0.3415
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0016 0.0037 0.2078
Schistosoma mansoni hypothetical protein 0.0019 0.0051 0.0051
Brugia malayi jmjC domain containing protein 0.0014 0.003 0.003
Schistosoma mansoni dishevelled 0.0011 0.0014 0.0014
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Echinococcus granulosus lysine specific demethylase 5A 0.0055 0.0214 0.1566
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0014 0.0101
Onchocerca volvulus Alhambra homolog 0.0045 0.0166 0.1742
Schistosoma mansoni cytochrome P450 0.0013 0.0023 0.0023
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0035 0.0124 0.0124
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0109 0.0455 0.0895
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.002 0.002
Schistosoma mansoni jumonji domain containing protein 0.0116 0.0488 0.0488
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.001 0.0071
Brugia malayi jmjC domain containing protein 0.0146 0.0623 0.0623
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0014 0.003 0.1962
Schistosoma mansoni cpg binding protein 0.0023 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0032 0.1871
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0005
Schistosoma mansoni hypothetical protein 0.0205 0.0884 0.0884
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.002 0.0214
Brugia malayi hypothetical protein 0.0011 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.002 0.002
Brugia malayi PHD-finger family protein 0.0016 0.0037 0.0037
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0014 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.002 0.002
Leishmania major cytochrome p450-like protein 0.0013 0.0023 0.0881
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013 0.0023 0.0038
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0014 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0032 0.0032
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0032 0.0032
Echinococcus granulosus lysine specific demethylase 6a 0.0014 0.003 0.0223
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0062 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0014 0.0101
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.002 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.001 0.001
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0155 0.9315
Trypanosoma brucei cytochrome P450, putative 0.0028 0.009 0.5694
Leishmania major cytochrome p450-like protein 0.0028 0.009 0.3942
Onchocerca volvulus 0.022 0.0955 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0051 0.2185
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0036 0.0264
Schistosoma mansoni hypothetical protein 0.001 0.0013 0.0013
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0032 0.0233
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.002 0.015
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0094 0.0094
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0146 0.0623 0.4556
Loa Loa (eye worm) Smad1 0.001 0.001 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0223 0.0967 1
Mycobacterium leprae Conserved hypothetical protein 0.0013 0.0023 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.002 0.015
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013 0.0023 0.0038
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0155 0.1604
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0032 0.0032
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0062 0.0116
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.2236 1 1
Trypanosoma brucei unspecified product 0.001 0.0011 0.0519
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0051 0.0374
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0036 0.0264
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.002 0.015
Brugia malayi Egg laying defective protein 4 0.0011 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.002 0.002
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0155 0.0155
Echinococcus multilocularis dnaJ subfamily B 0.0312 0.1367 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.002 0.002
Brugia malayi AF-10 protein 0.0015 0.0031 0.0031
Echinococcus multilocularis Smad4 0.001 0.001 0.0071
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0051 0.3156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Echinococcus multilocularis lysine specific demethylase 6a 0.0014 0.003 0.0223
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0071 0.0071
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0094 0.018
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0023 0.1464
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0032 0.1871
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0236 0.0236
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0035 0.0124 0.0905
Plasmodium vivax SET domain protein, putative 0.0028 0.0092 0.5451
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.001 0.0071
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.1133 0.5048 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.002 0.002
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.002 0.015
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0014 0.0014
Trichomonas vaginalis set domain proteins, putative 0.022 0.0955 0.9872
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0094 0.018
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0155 1
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0037 0.2078
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0014 0.0014
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0499 0.5162
Brugia malayi hypothetical protein 0.0023 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0119 0.0499 0.0499
Echinococcus multilocularis dna polymerase eta 0.0015 0.0032 0.0233
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0105
Echinococcus multilocularis JmjC domain containing protein 4 0.0014 0.003 0.0223
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0003 0.0035
Loa Loa (eye worm) hypothetical protein 0.006 0.0236 0.0236
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0195 0.1424
Echinococcus granulosus geminin 0.0205 0.0884 0.6466
Toxoplasma gondii PHD-finger domain-containing protein 0.0045 0.0166 0.0323
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.002 0.015
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0013 0.0023 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.002 0.015
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0051 0.0095
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0032 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0014 0.0101
Schistosoma mansoni nuclear hormone receptor 0.0012 0.002 0.002
Schistosoma mansoni jumonji domain containing protein 0.0014 0.003 0.003
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0051 0.294
Schistosoma mansoni dep domain containing protein 0.0011 0.0014 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0094 0.4141
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.0035
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0051 0.0374
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013 0.0023 0.0038
Onchocerca volvulus 0.0012 0.002 0.0214
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.0223 0.1628
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013 0.0023 0.0038
Giardia lamblia Fructose-bisphosphate aldolase 0.0223 0.0967 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.002 0.002
Plasmodium falciparum phd finger protein, putative 0.0045 0.0166 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0051 0.0374
Echinococcus granulosus transcription factor btf3 0.0042 0.0155 0.1135
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0011 0.0519
Leishmania major DNA polymerase eta, putative 0.0015 0.0032 0.1296
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0071 0.4556
Echinococcus granulosus JmjC domain containing protein 4 0.0014 0.003 0.0223
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0194 0.0835 0.0835
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0014
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0023 0.0166
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.0179 0.0179
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013 0.0023 0.0038
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.001 0.0071
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0013 0.0023 0.0038
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0014 0.0101
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0014 0.0101
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.002 0.002
Leishmania major hypothetical protein, conserved 0.0023 0.0071 0.3071
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0023 0.1464
Brugia malayi isocitrate dehydrogenase 0.0019 0.0051 0.0051
Onchocerca volvulus 0.0008 0.0003 0.0036
Schistosoma mansoni smad1 5 8 and 0.001 0.001 0.001
Echinococcus granulosus jumonji domain containing 1A 0.0014 0.003 0.0223
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013 0.0023 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.002 0.002
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0071 0.4131
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.009 0.009
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013 0.0023 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0094 0.4141
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0166 0.0166
Schistosoma mansoni transcription factor btf3 0.0042 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Echinococcus granulosus cGMP dependent protein kinase 1 0.0011 0.0014 0.0106
Giardia lamblia PHD finger protein 15 0.0045 0.0166 0.1438
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.006 0.006
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0499 0.0499
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0499 0.3652
Echinococcus multilocularis geminin 0.0205 0.0884 0.6466
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0014 0.0014
Brugia malayi CXXC zinc finger family protein 0.0022 0.0064 0.0064
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0051 0.0375
Schistosoma mansoni coup transcription factor 0.0012 0.002 0.002
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0015 0.0031 0.1836
Brugia malayi PHD-finger family protein 0.0045 0.0166 0.0166
Echinococcus multilocularis transcription factor btf3 0.0042 0.0155 0.1135
Brugia malayi MH2 domain containing protein 0.001 0.001 0.001
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013 0.0023 0.0038
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0045 0.0166 0.0166
Echinococcus granulosus GPCR family 2 0.0019 0.0051 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.002 0.002
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0003 0.0025
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.003 0.003
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.009 0.5788
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0014 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0109 0.0455 0.0895
Echinococcus multilocularis protein patched 0.0051 0.0195 0.1424
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0051 0.0375
Loa Loa (eye worm) oxidoreductase 0.0008 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0013 0.0023 0.0023
Trypanosoma brucei unspecified product 0.0015 0.0032 0.1871
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0035 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013 0.0023 0.0038
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0013 0.0023 0.0038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.002 0.015
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0014 0.0014
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.002 0.002
Brugia malayi Bromodomain containing protein 0.0045 0.0166 0.0166
Brugia malayi hypothetical protein 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0003 0.0003
Brugia malayi MH2 domain containing protein 0.0144 0.0613 0.0613
Brugia malayi MH1 domain containing protein 0.001 0.001 0.001
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0032 0.0329
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0223 0.0434
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013 0.0023 0.1273
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.003 0.003
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0013 0.0023 0.0038
Schistosoma mansoni Smad4 0.001 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0049 0.0186 0.0186
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013 0.0023 0.0038
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0015 0.0032 0.0056
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.002 0.0214
Brugia malayi ecdysteroid receptor 0.0012 0.002 0.002
Brugia malayi MH1 domain containing protein 0.001 0.001 0.001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.002 0.015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.0124 0.0905
Echinococcus multilocularis jumonji domain containing protein 0.0062 0.0245 0.1791
Toxoplasma gondii pantoate-beta-alanine ligase 0.1133 0.5048 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0071 0.4131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.002 0.002
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0032 0.0056
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0166 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.002 0.002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0223 0.0434
Brugia malayi Cytochrome P450 family protein 0.0028 0.009 0.009
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0071 0.4556
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0195 0.0195
Echinococcus granulosus cpg binding protein 0.0023 0.007 0.051
Echinococcus granulosus FTZ F1 alpha 0.0012 0.002 0.015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0094 0.0974
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0032 0.0056
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0013 0.0093
Brugia malayi jmjC domain containing protein 0.0014 0.003 0.003
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0062
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0166 0.0166
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.002 0.015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.002 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0032 0.205
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0015 0.0032 0.1296
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.002 0.015
Plasmodium vivax JmjC domain containing protein 0.0014 0.003 0.166
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0032 0.0032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0051 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013 0.0023 0.0038
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0032 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0094 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.2236 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0092 0.0674
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0094 0.018
Echinococcus granulosus cGMP dependent protein kinase 0.0011 0.0014 0.0106
Echinococcus multilocularis protein dispatched 1 0.0058 0.0227 0.166
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0051 0.0375
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0003 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0092 0.0092
Schistosoma mansoni thyroid hormone receptor 0.0012 0.002 0.002
Brugia malayi jmjC domain containing protein 0.0014 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0049 0.0186 0.0186
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0014 0.003 0.0054
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.009 0.009
Echinococcus granulosus cGMP dependent protein kinase 1 0.0011 0.0014 0.0106
Treponema pallidum fructose-bisphosphate aldolase 0.0223 0.0967 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0035 0.0124 0.0905
Brugia malayi Cytochrome P450 family protein 0.0013 0.0023 0.0023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0094 0.0974
Plasmodium falciparum cGMP-dependent protein kinase 0.0011 0.0014 0.0678
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0051 0.0051
Schistosoma mansoni patched 1 0.0051 0.0195 0.0195
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.002 0.002
Schistosoma mansoni protein phosphatase 2C 0.0014 0.003 0.003
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0003 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.002 0.002
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0013 0.0023 0.0038
Leishmania major cytochrome p450-like protein 0.0013 0.0023 0.0881
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0064 0.0064
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0155 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013 0.0023 0.0038
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0155 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0094 0.4141
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.009 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0014 0.003 0.003
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0312 0.1367 0.1367
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0014 0.0014
Onchocerca volvulus 0.0029 0.0094 0.0986
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013 0.0023 0.0038
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0071 0.4131
Onchocerca volvulus 0.0008 0.0003 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Echinococcus multilocularis cpg binding protein 0.0023 0.007 0.051
Schistosoma mansoni smad1 5 8 and 0.001 0.001 0.001
Trichomonas vaginalis DNA polymerase eta, putative 0.0015 0.0032 0.0329
Schistosoma mansoni hypothetical protein 0.0019 0.0051 0.0051
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0094 0.018
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0195 0.1424
Brugia malayi CHE-14 protein 0.0051 0.0195 0.0195
Loa Loa (eye worm) jmjC domain-containing protein 0.0092 0.038 0.038
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0155 0.9315
Mycobacterium ulcerans hypothetical protein 0.0029 0.0094 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0011 0.0519
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0109 0.0455 0.0895
Brugia malayi N-terminal motif family protein 0.0218 0.0944 0.0944
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0014 0.0101
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0003 0.0219
Echinococcus multilocularis expressed conserved protein 0.0011 0.0014 0.0106
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0223 0.0434
Loa Loa (eye worm) hypothetical protein 0.0062 0.0246 0.0246
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013 0.0023 0.0038
Trypanosoma brucei unspecified product 0.001 0.0011 0.0519
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0062
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.015 0.015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.002 0.002
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.015 0.015
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.002 0.015
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0015 0.0031 0.1836
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013 0.0023 0.0038
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1133 0.5048 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013 0.0023 0.1464
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.002 0.0214
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0051 0.0375
Echinococcus granulosus jumonji domain containing protein 0.0062 0.0245 0.1791
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.002 0.002
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0003 0.0003
Schistosoma mansoni DNA polymerase eta 0.0015 0.0032 0.0032
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0146 0.0623 0.4556
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0092 0.0674
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0032 0.1871
Leishmania major protein kinase, putative 0.0011 0.0014 0.0504
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0236 0.0236
Brugia malayi steroid hormone receptor 0.0012 0.002 0.002
Brugia malayi hypothetical protein 0.0011 0.0014 0.0014
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0071 0.4435
Loa Loa (eye worm) hypothetical protein 0.0051 0.0195 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0499 0.3652
Schistosoma mansoni jumonji/arid domain-containing protein 0.0055 0.0214 0.0214
Onchocerca volvulus 0.0008 0.0003 0.0036
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0094 0.018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0092 0.0674
Schistosoma mansoni hypothetical protein 0.0041 0.015 0.015
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0094 0.018
Echinococcus multilocularis 0.0013 0.0023 0.0166
Echinococcus granulosus expressed conserved protein 0.0112 0.0467 0.3415
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0051 0.294
Brugia malayi nuclear receptor NHR-88 0.0012 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0011 0.0014 0.0106
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0092 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.002 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0032 0.1871
Loa Loa (eye worm) hypothetical protein 0.0218 0.0944 0.0944
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0085 0.0625
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0049 0.0186 0.0186
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0094 0.0094
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.003 0.003
Schistosoma mansoni phosphatidylserine receptor 0.0014 0.003 0.003
Echinococcus multilocularis lysine specific demethylase 5A 0.0054 0.0208 0.1525
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0051 0.0095
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0155 0.1604
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0056 0.0105
Entamoeba histolytica hypothetical protein 0.0042 0.0155 0.1604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.002 0.002
Echinococcus granulosus Smad4 0.001 0.001 0.0071
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0003 0.0003
Brugia malayi MH2 domain containing protein 0.001 0.001 0.001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0092 0.0092
Schistosoma mansoni smad1 5 8 and 0.001 0.001 0.001
Echinococcus multilocularis dna polymerase kappa 0.0015 0.0032 0.0233
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0003 0.0219
Schistosoma mansoni hypothetical protein 0.0019 0.0051 0.0051
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0155 0.1604
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0013 0.0023 0.0038
Plasmodium falciparum JmjC domain-containing protein, putative 0.0014 0.003 0.166
Echinococcus granulosus peregrin 0.0045 0.0166 0.1217
Loa Loa (eye worm) cytochrome P450 0.0013 0.0023 0.0023
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0013 0.0023 0.0038
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0051 0.3306
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0013 0.0023 0.0038
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0013 0.0023 0.0038
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0223 0.0223
Leishmania major protein kinase, putative 0.0011 0.0014 0.0504
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0037
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0071 0.0133
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0011 0.0014 0.0022
Leishmania major hypothetical protein, conserved 0.0014 0.003 0.1234
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0062
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0013 0.0023 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.002 0.002
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0014 0.0101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0094 0.018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0094 0.018
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.0944 0.9888
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.002 0.002
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0066 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0032 0.1871
Brugia malayi Pre-SET motif family protein 0.0194 0.0835 0.0835
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.001 0.001
Brugia malayi Pre-SET motif family protein 0.0028 0.0092 0.0092
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0062 0.3577
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0728 0.5326
Onchocerca volvulus 0.0022 0.0064 0.0671
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0728 0.5326
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.002 0.015
Brugia malayi nuclear hormone receptor 0.0012 0.002 0.002
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0003 0.0219
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0223 0.0967 1
Schistosoma mansoni hypothetical protein 0.0049 0.0186 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0011 0.0519
Echinococcus granulosus smad 0.001 0.001 0.0071
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0032 0.205
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.0223 0.0434
Echinococcus granulosus dna polymerase kappa 0.0015 0.0032 0.0233
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.0223 0.0434
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.009 0.5788
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0043 0.0157 0.0304

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.99 uM Antiproliferative activity against human SK-N-MC cells by MTT assay ChEMBL. 17963372
IC50 (functional) = 0.99 uM Antiproliferative activity against human SK-N-MC cells by MTT assay ChEMBL. 17963372
IC50 (binding) > 100 uM Inhibition of ribonuclease H activity of HIV1 reverse transcriptase using as poly(dC)-[3H]poly(rG) as substrate ChEMBL. 22361685

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17963372

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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