Detailed information for compound 47689

Basic information

Technical information
  • TDR Targets ID: 47689
  • Name: (2S)-3-(2-amino-1,3-thiazol-4-yl)-N-[(2S,3R,4 S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan- 2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino )-3-phenylpropanoyl]amino]propanamide
  • MW: 708.932 | Formula: C33H52N6O7S2
  • H donors: 6 H acceptors: 7 LogP: 3.87 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC(C[C@@H]([C@@H]([C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NS(=O)(=O)N1CCOCC1)Cc1ccccc1)Cc1csc(n1)N)CC1CCCCC1)O)O)C
  • InChi: 1S/C33H52N6O7S2/c1-22(2)17-29(40)30(41)26(18-23-9-5-3-6-10-23)36-31(42)27(20-25-21-47-33(34)35-25)37-32(43)28(19-24-11-7-4-8-12-24)38-48(44,45)39-13-15-46-16-14-39/h4,7-8,11-12,21-23,26-30,38,40-41H,3,5-6,9-10,13-20H2,1-2H3,(H2,34,35)(H,36,42)(H,37,43)/t26-,27-,28-,29-,30+/m0/s1
  • InChiKey: QGJKHQRFJGLJLV-VFFRCKCKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-3-(2-aminothiazol-4-yl)-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methyl-hexyl]-2-[[(2S)-2-(morpholinosulfonylamino)-3-phenyl-propanoyl]amino]propanamide
  • (2S)-3-(2-amino-4-thiazolyl)-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-2-[[(2S)-2-(morpholinosulfonylamino)-1-oxo-3-phenylpropyl]amino]propanamide
  • (2S)-3-(2-azanyl-1,3-thiazol-4-yl)-N-[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methyl-heptan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenyl-propanoyl]amino]propanamide
  • (2S)-3-(2-aminothiazol-4-yl)-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methyl-hexyl]-2-[[(2S)-2-(morpholinosulfonylamino)-3-phenyl-propanoyl]amino]propionamide
  • CI 992
  • (2S)-3-(2-amino-1,3-thiazol-4-yl)-N-[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methyl-heptan-2-yl]-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenyl-propanoyl]amino]propanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens renin Starlite/ChEMBL References
Bos taurus Cathepsin D Starlite/ChEMBL References
Rattus norvegicus Renin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii plasmepsin Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum Cathepsin D precursor, putative Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Renin, related Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi aspartyl protease, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin I Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus granulosus cathepsin d lysosomal aspartyl protease Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin II Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl proteinase (eimepsin), putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) aspartic protease BmAsp-2 Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva pepsinogen, putative Get druggable targets OG5_126885 All targets in OG5_126885
Babesia bovis eukaryotic aspartyl protease family protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl protease ASP1 Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva cathepsin E, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K01379 cathepsin D [EC3.4.23.5], putative Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Pepsinogen A1, related Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax aspartyl proteinase, putative Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium hominis aspartyl protease precursor Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium parvum membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain Get druggable targets OG5_126885 All targets in OG5_126885
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans secretory aspartyl proteinase SAP1p Cathepsin D   390 aa 386 aa 29.0 %
Candida albicans secretory aspartyl proteinase SAP4p Renin   402 aa 341 aa 24.3 %
Candida albicans secretory aspartyl proteinase SAP7p Cathepsin D   390 aa 385 aa 24.4 %
Toxoplasma gondii aspartyl protease ASP3 Renin   402 aa 324 aa 29.9 %
Candida albicans secretory aspartyl proteinase SAP6p Renin   402 aa 341 aa 24.9 %
Candida albicans secretory aspartyl proteinase SAP3p Cathepsin D   390 aa 370 aa 25.9 %
Candida albicans secretory aspartyl proteinase SAP1p Cathepsin D   390 aa 386 aa 29.0 %
Schistosoma mansoni memapsin-2 (A01 family) Renin   402 aa 440 aa 21.1 %
Babesia bovis aspartyl protease, putative Renin   402 aa 350 aa 28.3 %
Candida albicans secretory aspartyl proteinase SAP3p Cathepsin D   390 aa 370 aa 25.9 %
Candida albicans secretory aspartyl proteinase SAP2p Cathepsin D   390 aa 378 aa 27.5 %
Plasmodium berghei plasmepsin X Renin   402 aa 329 aa 29.8 %
Babesia bovis aspartyl protease, putative Renin   402 aa 333 aa 25.8 %
Brugia malayi aspartic protease BmAsp-1, identical Cathepsin D   390 aa 406 aa 29.6 %
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein Cathepsin D   390 aa 383 aa 25.1 %
Candida albicans secretory aspartyl proteinase SAP9p, related to SAP10 Cathepsin D   390 aa 315 aa 25.1 %
Toxoplasma gondii aspartyl protease Renin   402 aa 417 aa 28.5 %
Candida albicans secretory aspartyl proteinase SAP10p, related to SAP9p Renin   402 aa 344 aa 21.8 %
Neospora caninum hypothetical protein Renin   402 aa 324 aa 29.6 %
Plasmodium falciparum plasmepsin IX Renin   402 aa 438 aa 25.3 %
Candida albicans secretory aspartyl proteinase SAP9p, related to SAP10 Cathepsin D   390 aa 315 aa 25.1 %
Onchocerca volvulus Renin   402 aa 340 aa 30.6 %
Candida albicans secretory aspartyl proteinase SAP4p Renin   402 aa 341 aa 24.3 %
Plasmodium vivax aspartyl protease, putative Renin   402 aa 385 aa 27.8 %
Candida albicans secretory aspartyl proteinase SAP10p, related to SAP9p Renin   402 aa 344 aa 21.8 %
Candida albicans secretory aspartyl proteinase SAP8p Renin   402 aa 333 aa 23.7 %
Dictyostelium discoideum hypothetical protein Cathepsin D   390 aa 374 aa 24.9 %
Candida albicans secretory aspartyl proteinase SAP6p Renin   402 aa 341 aa 24.6 %
Candida albicans secretory aspartyl proteinase SAP5p Renin   402 aa 354 aa 24.6 %
Plasmodium vivax aspartyl protease, putative Renin   402 aa 455 aa 25.1 %
Candida albicans secretory aspartyl proteinase SAP7p Cathepsin D   390 aa 385 aa 24.4 %
Plasmodium falciparum plasmepsin III Renin   402 aa 345 aa 29.9 %
Candida albicans secretory aspartyl proteinase SAP5p Renin   402 aa 354 aa 24.6 %
Onchocerca volvulus Cathepsin D   390 aa 329 aa 22.5 %
Plasmodium yoelii Eukaryotic aspartyl protease, putative Renin   402 aa 329 aa 29.5 %
Plasmodium berghei plasmepsin IX, putative Cathepsin D   390 aa 403 aa 25.8 %
Drosophila melanogaster CG31926 gene product from transcript CG31926-RB Renin   402 aa 415 aa 33.5 %
Neospora caninum Cathepsin D enzyme (EC 3.4.23.5), related Renin   402 aa 358 aa 30.4 %
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Cathepsin D   390 aa 388 aa 33.5 %
Candida albicans secretory aspartyl proteinase SAP8p Renin   402 aa 333 aa 23.7 %
Schistosoma japonicum Lysosomal aspartic protease precursor, putative Cathepsin D   390 aa 335 aa 32.5 %
Candida albicans secretory aspartyl proteinase SAP2p Cathepsin D   390 aa 378 aa 27.5 %
Plasmodium falciparum plasmepsin X renin 406 aa 352 aa 26.4 %
Plasmodium falciparum plasmepsin X Renin   402 aa 332 aa 29.8 %
Loa Loa (eye worm) aspartic protease BmAsp-1 Renin   402 aa 408 aa 26.5 %
Plasmodium berghei plasmepsin VII Renin   402 aa 360 aa 27.2 %
Onchocerca volvulus Putative 6-pyruvoyl tetrahydrobiopterin synthase Cathepsin D   390 aa 395 aa 30.9 %
Onchocerca volvulus Sphingomyelin phosphodiesterase 1 homolog Renin   402 aa 414 aa 40.3 %
Plasmodium knowlesi eukaryotic aspartyl protease, putative Renin   402 aa 328 aa 28.7 %
Cryptosporidium parvum secreted pepsinogen like aspartyl protease having a signal peptide Cathepsin D   390 aa 387 aa 24.0 %
Plasmodium knowlesi plasmepsin V, putative Cathepsin D   390 aa 436 aa 21.8 %
Plasmodium knowlesi aspartyl protease, putative Renin   402 aa 369 aa 27.1 %
Plasmodium falciparum plasmepsin VII Renin   402 aa 367 aa 24.3 %
Plasmodium yoelii pepsinogen A-related Cathepsin D   390 aa 387 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0295 0.0377
Echinococcus granulosus survival motor neuron protein 1 0.0505 0.2522 0.2522
Loa Loa (eye worm) hypothetical protein 0.0059 0.0183 0.0183
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0085 0.0085
Toxoplasma gondii cathepsin CPC1 0.0327 0.1589 0.2168
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0505 0.2522 0.2522
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0327 0.1589 0.2168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0295 0.0295
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0135 0.0584 0.0773
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0327 0.1589 0.2168
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0925 0.4725 0.4627
Mycobacterium ulcerans carboxylesterase, LipT 0.0135 0.0584 1
Entamoeba histolytica cysteine protease, putative 0.1422 0.7329 1
Echinococcus granulosus BC026374 protein S09 family 0.0135 0.0584 0.0584
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0085 0.0085
Echinococcus multilocularis survival motor neuron protein 1 0.0505 0.2522 0.2522
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Echinococcus granulosus cathepsin l cysteine peptidase 0.1422 0.7329 0.7329
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0085 0.0085
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0327 0.1589 0.1589
Loa Loa (eye worm) carboxylesterase 0.0135 0.0584 0.0584
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0177 0.0803 0.0803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.1931 1 1
Echinococcus granulosus muscleblind protein 0.0319 0.1547 0.1547
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0085 0.0085
Echinococcus granulosus aspartyl aminopeptidase 0.0059 0.0183 0.0183
Onchocerca volvulus 0.0135 0.0584 0.0797
Schistosoma mansoni gabp alpha 0.0059 0.0186 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus multilocularis GA binding protein alpha chain 0.0059 0.0186 0.0186
Echinococcus granulosus cathepsin L 0.0327 0.1589 0.1589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0135 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0497 0.2479 0.2479
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0119 0.0119
Entamoeba histolytica cysteine proteinase, putative 0.0824 0.4193 0.5612
Echinococcus multilocularis neuroligin 0.0135 0.0584 0.0584
Toxoplasma gondii aspartyl protease 0.0042 0.0094 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0085 0.0085
Echinococcus multilocularis musashi 0.0027 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0177 0.0803 0.0803
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0443 0.0443
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Brugia malayi bHLH-PAS transcription factor 0.0037 0.007 0.007
Plasmodium vivax aspartyl proteinase, putative 0.0177 0.0803 0.1095
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Trypanosoma cruzi cysteine peptidase, putative 0.1422 0.7329 0.7279
Echinococcus granulosus lamin dm0 0.0027 0.0016 0.0016
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0135 0.0584 0.0584
Echinococcus granulosus small conductance calcium activated potassium 0.0167 0.0749 0.0749
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1422 0.7329 0.7329
Plasmodium vivax aspartyl protease, putative 0.0042 0.0094 0.0129
Onchocerca volvulus 0.1422 0.7329 1
Brugia malayi Fli-1 protein 0.018 0.0818 0.0818
Loa Loa (eye worm) hypothetical protein 0.0925 0.4725 0.4725
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0119 0.0119
Mycobacterium tuberculosis Carboxylesterase LipT 0.0135 0.0584 0.1689
Onchocerca volvulus Huntingtin homolog 0.0127 0.054 0.0736
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0118 0.0495 0.0495
Mycobacterium leprae Probable lipase LipE 0.008 0.0295 1
Loa Loa (eye worm) carboxylesterase 0.0801 0.4073 0.4073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0085 0.0085
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0295 0.0472
Echinococcus granulosus microtubule associated protein 2 0.0672 0.3398 0.3398
Brugia malayi cathepsin Z-like cysteine proteinase 0.0327 0.1589 0.1589
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0854 0.435 0.435
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0059 0.0183 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0823 0.419 0.5706
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0327 0.1589 0.2168
Schistosoma mansoni hypothetical protein 0.0045 0.011 0.011
Loa Loa (eye worm) ctsf protein 0.1422 0.7329 0.7329
Onchocerca volvulus 0.004 0.0085 0.0116
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Loa Loa (eye worm) hypothetical protein 0.011 0.045 0.045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0085 0.0085
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0085 0.0085
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0295 0.0295
Schistosoma mansoni cathepsin C 0.0327 0.1589 0.1589
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0327 0.1589 0.1589
Echinococcus granulosus carboxylesterase 5A 0.0801 0.4073 0.4073
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0295 0.0157
Onchocerca volvulus Cathepsin L homolog 0.1422 0.7329 1
Echinococcus multilocularis acetylcholinesterase 0.0801 0.4073 0.4073
Schistosoma mansoni cathepsin F (C01 family) 0.0925 0.4725 0.4725
Echinococcus multilocularis cysteine protease 0.1422 0.7329 0.7329
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0085 0.0085
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0327 0.1589 0.2168
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0327 0.1589 0.2147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0564 0.0564
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1589 0.1589
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1931 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0129 0.0129
Brugia malayi Pepsin A precursor 0.0042 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0327 0.1589 0.2147
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0016
Brugia malayi cathepsin F-like cysteine proteinase 0.0497 0.2479 0.2479
Echinococcus granulosus single minded 2 0.0037 0.007 0.007
Schistosoma mansoni survival motor neuron protein 0.0103 0.0415 0.0415
Onchocerca volvulus 0.1422 0.7329 1
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Giardia lamblia Cysteine protease 0.0327 0.1589 0.3792
Trypanosoma cruzi cysteine peptidase, putative 0.0824 0.4193 0.4085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0327 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.0094 0.0369 0.0369
Schistosoma mansoni acetylcholinesterase 0.0135 0.0584 0.0584
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0118 0.0495 0.0495
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0295 0.0377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus granulosus Niemann Pick C1 protein 0.0155 0.0687 0.0687
Schistosoma mansoni hypothetical protein 0.0229 0.1077 0.1077
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Leishmania major hypothetical protein, conserved 0.008 0.0295 0.0157
Loa Loa (eye worm) hypothetical protein 0.0169 0.0761 0.0761
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0085 0.0085
Echinococcus granulosus jumonji domain containing protein 0.0033 0.0049 0.0049
Schistosoma mansoni cathepsin D (A01 family) 0.0522 0.2611 0.2611
Plasmodium vivax vivapain-2 0.1422 0.7329 1
Giardia lamblia Cathepsin B precursor 0.0327 0.1589 0.3792
Echinococcus granulosus tm gpcr rhodopsin 0.0854 0.435 0.435
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0085 0.0085
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0026 0.0026
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0135 0.0584 0.0584
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0824 0.4193 0.5612
Trypanosoma cruzi cruzipain precursor, putative 0.0497 0.2479 0.2339
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Onchocerca volvulus 0.0135 0.0584 0.0797
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0327 0.1589 0.2147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Onchocerca volvulus 0.008 0.0295 0.0403
Trypanosoma cruzi cysteine peptidase, putative 0.0497 0.2479 0.2339
Trypanosoma cruzi cruzipain precursor, putative 0.1422 0.7329 0.7279
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0824 0.4193 0.4193
Echinococcus granulosus intermediate filament protein 0.0027 0.0016 0.0016
Brugia malayi Eukaryotic aspartyl protease family protein 0.0042 0.0094 0.0094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1589 0.1589
Echinococcus multilocularis cysteine protease 0.1422 0.7329 0.7329
Entamoeba histolytica cysteine proteinase, putative 0.0925 0.4725 0.6356
Echinococcus granulosus expressed conserved protein 0.0102 0.0408 0.0408
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0415 0.0415
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0295 0.0472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0085 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Schistosoma mansoni transcription factor LCR-F1 0.0229 0.1077 0.1077
Plasmodium falciparum plasmepsin VII 0.0042 0.0094 0.0129
Schistosoma mansoni hypothetical protein 0.0045 0.011 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1589 0.2147
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1422 0.7329 1
Onchocerca volvulus Cathepsin F homolog 0.1422 0.7329 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0823 0.419 0.5608
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0119 0.0119
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0129 0.0129
Schistosoma mansoni thyroid hormone receptor 0.004 0.0085 0.0085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1589 0.1589
Trypanosoma cruzi cysteine proteinase, putative 0.0824 0.4193 0.4085
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0327 0.1589 0.1967
Schistosoma mansoni microtubule-associated protein tau 0.0672 0.3398 0.3398
Loa Loa (eye worm) hypothetical protein 0.0127 0.054 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0497 0.2479 0.2479
Echinococcus granulosus cathepsin L cysteine proteinase 0.1422 0.7329 0.7329
Schistosoma mansoni hypothetical protein 0.0045 0.011 0.011
Schistosoma mansoni calcium-activated potassium channel 0.0159 0.0706 0.0706
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0059 0.0183 0.0183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0327 0.1589 0.2147
Brugia malayi PAS domain containing protein 0.005 0.0139 0.0139
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1931 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0295 0.0377
Brugia malayi Papain family cysteine protease containing protein 0.0824 0.4193 0.4193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Plasmodium falciparum serine repeat antigen 7 0.0327 0.1589 0.2168
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Entamoeba histolytica cysteine proteinase, putative 0.0824 0.4193 0.5612
Toxoplasma gondii cathepsin CPL 0.1422 0.7329 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0085 0.0085
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0059 0.0183 0.0224
Brugia malayi Aspartyl aminopeptidase 0.0059 0.0183 0.0183
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0085 0.0085
Brugia malayi Carboxylesterase family protein 0.0801 0.4073 0.4073
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0327 0.1589 0.3792
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0059 0.0183 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1422 0.7329 1
Brugia malayi nuclear hormone receptor 0.004 0.0085 0.0085
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Giardia lamblia Cathepsin B precursor 0.0823 0.419 1
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Plasmodium vivax unspecified product 0.0327 0.1589 0.2168
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1422 0.7329 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.045 0.045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Onchocerca volvulus 0.008 0.0295 0.0403
Brugia malayi Cathepsin L-like precursor 0.0497 0.2479 0.2479
Brugia malayi fibroinase precursor 0.0327 0.1589 0.1589
Brugia malayi Papain family cysteine protease containing protein 0.1422 0.7329 0.7329
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0135 0.0584 0.0584
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1931 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.0452 0.0452
Brugia malayi Ets-domain containing protein 0.0059 0.0186 0.0186
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0135 0.0584 0.1689
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0824 0.4193 0.571
Loa Loa (eye worm) hypothetical protein 0.0075 0.0268 0.0268
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Entamoeba histolytica cysteine proteinase 2 0.0824 0.4193 0.5612
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0059 0.0183 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0824 0.4193 0.5612
Echinococcus multilocularis lamin 0.0027 0.0016 0.0016
Brugia malayi jmjC domain containing protein 0.0078 0.0285 0.0285
Onchocerca volvulus 0.0094 0.0369 0.0504
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0016 0.0016
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0135 0.0584 0.0584
Echinococcus multilocularis GPCR, family 2 0.0035 0.0057 0.0057
Plasmodium falciparum cysteine proteinase falcipain 3 0.1422 0.7329 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1589 0.1589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Toxoplasma gondii preprocathepsin c precursor, putative 0.0327 0.1589 0.2168
Onchocerca volvulus 0.0038 0.0073 0.01
Brugia malayi cathepsin L precursor 0.0327 0.1589 0.1589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Schistosoma mansoni cathepsin S (C01 family) 0.0327 0.1589 0.1589
Echinococcus granulosus cathepsin l1 0.1422 0.7329 0.7329
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0059 0.0183 0.0224
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0327 0.1589 0.2168
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0497 0.2479 0.2479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0119 0.0498 0.0498
Loa Loa (eye worm) aspartyl aminopeptidase 0.0059 0.0183 0.0183
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0133 0.0133
Onchocerca volvulus 0.1422 0.7329 1
Brugia malayi Carboxylesterase family protein 0.0135 0.0584 0.0584
Schistosoma mansoni cathepsin D (A01 family) 0.0522 0.2611 0.2611
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Brugia malayi nuclear receptor NHR-88 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0295 0.0472
Plasmodium falciparum serine repeat antigen 1 0.0327 0.1589 0.2168
Brugia malayi Carboxylesterase family protein 0.0135 0.0584 0.0584
Brugia malayi aspartic protease BmAsp-1, identical 0.0042 0.0094 0.0094
Plasmodium vivax unspecified product 0.0824 0.4193 0.5721
Trypanosoma cruzi cysteine protease, putative 0.0824 0.4193 0.4085
Onchocerca volvulus 0.0135 0.0584 0.0797
Brugia malayi beta-lactamase family protein 0.008 0.0295 0.0295
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0823 0.419 0.4082
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0327 0.1589 0.2168
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0295 0.0377
Loa Loa (eye worm) hypothetical protein 0.0094 0.0369 0.0369
Toxoplasma gondii aspartyl protease ASP3 0.0042 0.0094 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Onchocerca volvulus 0.1422 0.7329 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0042 0.0094 0.0094
Echinococcus granulosus neuroligin 0.0135 0.0584 0.0584
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0085 0.0116
Echinococcus granulosus FTZ F1 alpha 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0801 0.4073 0.4073
Onchocerca volvulus 0.008 0.0295 0.0403
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0925 0.4725 0.6437
Loa Loa (eye worm) hypothetical protein 0.0497 0.2479 0.2479
Schistosoma mansoni gliotactin 0.0135 0.0584 0.0584
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0059 0.0183 0.0183
Onchocerca volvulus Cathepsin L homolog 0.0327 0.1589 0.2168
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0801 0.4073 0.4073
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0295 0.0377
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0295 0.0295
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.1422 0.7329 0.7329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0177 0.0803 0.1072
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0823 0.419 0.5608
Onchocerca volvulus 0.0027 0.0016 0.0022
Echinococcus granulosus zinc finger transcription factor gli2 0.0309 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Mycobacterium tuberculosis Conserved protein 0.008 0.0295 0.0472
Loa Loa (eye worm) hypothetical protein 0.0041 0.0089 0.0089
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1422 0.7329 0.7329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0129 0.0129
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0497 0.2479 0.2479
Leishmania major cysteine peptidase A (CPA) 0.1422 0.7329 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0057 0.0057
Plasmodium vivax unspecified product 0.0497 0.2479 0.3383
Plasmodium falciparum serine repeat antigen 9 0.0327 0.1589 0.2168
Echinococcus granulosus lysine specific demethylase 5A 0.0029 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0327 0.1589 0.3792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0177 0.0803 0.0803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Giardia lamblia Cysteine protease 0.0327 0.1589 0.3792
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0177 0.0803 0.0803
Brugia malayi MH2 domain containing protein 0.0131 0.0564 0.0564
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.4275 0.4275
Onchocerca volvulus 0.0042 0.0094 0.0129
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0327 0.1589 0.1589
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Echinococcus multilocularis carboxylesterase 5A 0.0801 0.4073 0.4073
Plasmodium falciparum serine repeat antigen 5 0.0327 0.1589 0.2168
Plasmodium vivax hypothetical protein, conserved 0.008 0.0295 0.0403
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Loa Loa (eye worm) hypothetical protein 0.0059 0.0183 0.0183
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0085 0.0085
Schistosoma mansoni cathepsin s 0.0497 0.2479 0.2479
Schistosoma mansoni thyroid hormone receptor 0.004 0.0085 0.0085
Brugia malayi Carboxylesterase family protein 0.0135 0.0584 0.0584
Onchocerca volvulus 0.0086 0.0325 0.0444
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Schistosoma mansoni calcium-activated potassium channel 0.0167 0.0749 0.0749
Plasmodium falciparum serine repeat antigen 8 0.0327 0.1589 0.2168
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.007 0.007
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0327 0.1589 0.1589
Brugia malayi cathepsin F-like cysteine proteinase 0.0327 0.1589 0.1589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0327 0.1589 0.2168
Schistosoma mansoni nuclear hormone receptor 0.004 0.0085 0.0085
Brugia malayi cathepsin L-like cysteine proteinase 0.0327 0.1589 0.1589
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0135 0.0584 0.0584
Giardia lamblia Hypothetical protein 0.0327 0.1589 0.3792
Loa Loa (eye worm) beta-lactamase 0.008 0.0295 0.0295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0085 0.0085
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0026 0.0026
Brugia malayi cathepsin L-like precursor 0.0925 0.4725 0.4725
Schistosoma mansoni hypothetical protein 0.0045 0.011 0.011
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0319 0.1547 0.1547
Echinococcus multilocularis transcription factor eb 0.0119 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Loa Loa (eye worm) aspartyl protease 6 0.0042 0.0094 0.0094
Entamoeba histolytica hypothetical protein 0.0229 0.1077 0.1252
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0059 0.0186 0.0186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0085 0.0085
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0564 0.0564
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0229 0.1077 0.1077
Brugia malayi intermediate filament protein 0.0027 0.0016 0.0016
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0078 0.0285 0.0285
Schistosoma mansoni jumonji domain containing protein 0.0062 0.02 0.02
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0042 0.0094 0.0129
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0443 0.0443
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0085 0.0116
Loa Loa (eye worm) zinc finger protein 0.0309 0.1494 0.1494
Plasmodium falciparum plasmepsin I 0.0177 0.0803 0.1095
Echinococcus multilocularis para nitrobenzyl esterase 0.0135 0.0584 0.0584
Plasmodium falciparum plasmepsin VI 0.0177 0.0803 0.1095
Plasmodium vivax aspartyl protease, putative 0.0042 0.0094 0.0129
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0119 0.0119
Schistosoma mansoni cathepsin F (C01 family) 0.1422 0.7329 0.7329
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0057 0.0057
Plasmodium falciparum plasmepsin III 0.0042 0.0094 0.0129
Onchocerca volvulus 0.0135 0.0584 0.0797
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0014
Onchocerca volvulus 0.0135 0.0584 0.0797
Loa Loa (eye worm) hypothetical protein 0.0057 0.0173 0.0173
Entamoeba histolytica cysteine proteinase, putative 0.0824 0.4193 0.5612
Brugia malayi hypothetical protein 0.0229 0.1077 0.1077
Plasmodium falciparum serine repeat antigen 3 0.0327 0.1589 0.2168
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1422 0.7329 0.7329
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Entamoeba histolytica cysteine protease, putative 0.0327 0.1589 0.1967
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0824 0.4193 0.4193
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0327 0.1589 0.2168
Onchocerca volvulus 0.0103 0.0415 0.0566
Brugia malayi Cathepsin L-like precursor 0.1422 0.7329 0.7329
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0925 0.4725 0.4725
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0085 0.0085
Plasmodium falciparum plasmepsin VIII, putative 0.0042 0.0094 0.0129
Echinococcus multilocularis cathepsin L cysteine protease 0.1422 0.7329 0.7329
Onchocerca volvulus 0.0027 0.0016 0.0022
Trypanosoma cruzi cysteine proteinase, putative 0.0824 0.4193 0.4085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0824 0.4193 0.571
Giardia lamblia Cysteine protease 0.0327 0.1589 0.3792
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.008 0.0295 0.0295
Echinococcus granulosus lamin 0.0027 0.0016 0.0016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0327 0.1589 0.1589
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0295 0.0472
Echinococcus granulosus GA binding protein alpha chain 0.0059 0.0186 0.0186
Loa Loa (eye worm) acetylcholinesterase 1 0.0801 0.4073 0.4073
Mycobacterium ulcerans lipase LipD 0.008 0.0295 0.4373
Brugia malayi Carboxylesterase family protein 0.0135 0.0584 0.0584
Brugia malayi hypoxia-induced factor 1 0.0156 0.0692 0.0692
Brugia malayi hypothetical protein 0.0505 0.2522 0.2522
Trichomonas vaginalis conserved hypothetical protein 0.0327 0.1589 0.2147
Echinococcus granulosus transcription factor eb 0.0119 0.0498 0.0498
Plasmodium falciparum serine repeat antigen 4 0.0327 0.1589 0.2168
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0823 0.419 0.419
Schistosoma mansoni single-minded 0.005 0.0139 0.0139
Giardia lamblia Cathepsin B precursor 0.0823 0.419 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Giardia lamblia Cathepsin B precursor 0.0823 0.419 1
Toxoplasma gondii aspartyl protease ASP1 0.0177 0.0803 0.1095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0925 0.4725 0.6437
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0085 0.0085
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0026 0.0026
Brugia malayi beta-lactamase 0.008 0.0295 0.0295
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0295 0.4373
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.0369 0.0369
Onchocerca volvulus 0.0327 0.1589 0.2168
Entamoeba histolytica cysteine proteinase 1, putative 0.0824 0.4193 0.5612
Schistosoma mansoni coup transcription factor 0.004 0.0085 0.0085
Plasmodium vivax vivapain-3 0.0824 0.4193 0.5721
Brugia malayi beta-lactamase family protein 0.008 0.0295 0.0295
Echinococcus multilocularis protein dispatched 1 0.0053 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0295 0.0295
Plasmodium vivax serine-repeat antigen (SERA) 0.0327 0.1589 0.2168
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Mycobacterium tuberculosis Conserved protein 0.008 0.0295 0.0472
Echinococcus multilocularis microtubule associated protein 2 0.0672 0.3398 0.3398
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Onchocerca volvulus 0.1422 0.7329 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Trypanosoma cruzi cysteine peptidase, putative 0.1422 0.7329 0.7279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0085 0.0085
Brugia malayi Cathepsin L-like precursor 0.0925 0.4725 0.4725
Loa Loa (eye worm) carboxylesterase 0.0135 0.0584 0.0584
Echinococcus multilocularis cathepsin b 0.1931 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0127 0.054 0.054
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0327 0.1589 0.2168
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0824 0.4193 0.4085
Schistosoma mansoni hypothetical protein 0.0525 0.2627 0.2627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0085 0.0085
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0085 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0129 0.0129
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0085 0.0085
Echinococcus multilocularis expressed conserved protein 0.0102 0.0408 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0085 0.0085
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0177 0.0803 0.1095
Echinococcus multilocularis jumonji domain containing protein 0.0033 0.0049 0.0049
Echinococcus granulosus acetylcholinesterase 0.0801 0.4073 0.4073
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0046 0.0046
Giardia lamblia Cathepsin B precursor 0.0327 0.1589 0.3792
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0057
Plasmodium falciparum plasmepsin II 0.0177 0.0803 0.1095
Schistosoma mansoni lamin 0.0027 0.0016 0.0016
Echinococcus multilocularis protein patched 0.0046 0.0119 0.0119
Plasmodium vivax plasmepsin V, putative 0.0042 0.0094 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0327 0.1589 0.1589
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0142 0.0142
Mycobacterium tuberculosis Conserved protein 0.008 0.0295 0.0472
Plasmodium falciparum cysteine proteinase falcipain 1 0.0824 0.4193 0.5721
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0119 0.0136
Echinococcus granulosus geminin 0.0525 0.2627 0.2627
Plasmodium vivax aspartyl proteinase, putative 0.0042 0.0094 0.0129
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0512 0.2559 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0085 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0085 0.0085
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0085 0.0085
Onchocerca volvulus 0.1422 0.7329 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0327 0.1589 0.2147
Schistosoma mansoni hypothetical protein 0.0103 0.0415 0.0415
Plasmodium falciparum serine repeat antigen 6 0.0327 0.1589 0.2168
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0295 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0295 0.0114
Onchocerca volvulus Huntingtin homolog 0.0127 0.054 0.0736
Entamoeba histolytica hypothetical protein 0.0229 0.1077 0.1252
Loa Loa (eye worm) hypothetical protein 0.0084 0.0313 0.0313
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0085 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Brugia malayi hypothetical protein 0.0169 0.0761 0.0761
Brugia malayi hypothetical protein 0.0042 0.0094 0.0094
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0327 0.1589 0.1967
Brugia malayi Muscleblind-like protein 0.0319 0.1547 0.1547
Plasmodium vivax aspartyl protease, putative 0.0042 0.0094 0.0129
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Schistosoma mansoni ets-related 0.018 0.0818 0.0818
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0042 0.0094 0.0094
Toxoplasma gondii cathepsin CPC2 0.0327 0.1589 0.2168
Plasmodium falciparum plasmepsin IV 0.0177 0.0803 0.1095
Brugia malayi aspartic protease BmAsp-2, identical 0.0042 0.0094 0.0094
Schistosoma mansoni memapsin-2 (A01 family) 0.0042 0.0094 0.0094
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0327 0.1589 0.1589
Echinococcus granulosus GPCR family 2 0.0035 0.0057 0.0057
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0295 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0295 0.0114
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0135 0.0584 0.0584
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0085 0.0085
Brugia malayi ecdysteroid receptor 0.004 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0327 0.1589 0.2147
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.1589 0.1589
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1931 1 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0177 0.0803 0.0803
Brugia malayi hypothetical protein 0.0135 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0046 0.0119 0.0119
Echinococcus multilocularis cathepsin L 0.0824 0.4193 0.4193
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0085 0.0085
Trypanosoma cruzi cysteine peptidase, putative 0.1422 0.7329 0.7279
Plasmodium falciparum serine repeat antigen 2 0.0327 0.1589 0.2168
Brugia malayi hypothetical protein 0.0042 0.0094 0.0094
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0443 0.0364
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0085 0.0085
Schistosoma mansoni lamin 0.0027 0.0016 0.0016
Giardia lamblia Encystation-specific protease 0.0327 0.1589 0.3792
Trichomonas vaginalis spcc417.12 protein, putative 0.0135 0.0584 0.0773
Brugia malayi Trypsin family protein 0.0094 0.0369 0.0369
Echinococcus multilocularis Niemann Pick C1 protein 0.0155 0.0687 0.0687
Schistosoma mansoni intermediate filament proteins 0.0027 0.0016 0.0016
Echinococcus multilocularis cathepsin L cysteine protease 0.1422 0.7329 0.7329
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0057 0.0057
Onchocerca volvulus Cathepsin L homolog 0.1422 0.7329 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0327 0.1589 0.3792
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Echinococcus multilocularis small conductance calcium activated potassium 0.0167 0.0749 0.0749
Trichomonas vaginalis esterase, putative 0.008 0.0295 0.0377
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0085 0.0116
Schistosoma mansoni cathepsin B (C01 family) 0.0327 0.1589 0.1589
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0085 0.0085
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0229 0.1077 0.1077
Schistosoma mansoni hypothetical protein 0.0525 0.2627 0.2627
Loa Loa (eye worm) cathepsin B 0.0823 0.419 0.419
Loa Loa (eye worm) hypothetical protein 0.0319 0.1547 0.1547
Brugia malayi Carboxylesterase family protein 0.0801 0.4073 0.4073
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus multilocularis cathepsin b 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0051 0.0141 0.0141
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0085 0.0085
Onchocerca volvulus 0.0042 0.0094 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus multilocularis muscleblind protein 0.0319 0.1547 0.1547
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0085 0.0085
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0824 0.4193 0.4193
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Echinococcus granulosus cathepsin b 0.1931 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0327 0.1589 0.1432
Brugia malayi Cathepsin L-like precursor 0.0925 0.4725 0.4725
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0085 0.0085
Echinococcus multilocularis muscleblind protein 1 0.0319 0.1547 0.1547
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0085 0.0085
Brugia malayi steroid hormone receptor 0.004 0.0085 0.0085
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Onchocerca volvulus 0.1422 0.7329 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0135 0.0584 0.1689
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0327 0.1589 0.2147
Entamoeba histolytica hypothetical protein 0.0229 0.1077 0.1252
Plasmodium falciparum plasmepsin V 0.0042 0.0094 0.0129
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0295 0.0472
Loa Loa (eye worm) fibroinase 0.1422 0.7329 0.7329
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0327 0.1589 0.2168
Echinococcus multilocularis aspartyl aminopeptidase 0.0059 0.0183 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0129 0.0129
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Mycobacterium leprae conserved hypothetical protein 0.008 0.0295 1
Onchocerca volvulus 0.0925 0.4725 0.6447
Brugia malayi jmjC domain containing protein 0.0029 0.0026 0.0026
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0295 0.0472
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0057 0.0057
Giardia lamblia Cathepsin L-like protease 0.0327 0.1589 0.3792
Brugia malayi Papain family cysteine protease containing protein 0.0327 0.1589 0.1589
Plasmodium vivax serine-repeat antigen (SERA) 0.0327 0.1589 0.2168
Loa Loa (eye worm) hypothetical protein 0.0925 0.4725 0.4725
Giardia lamblia Cathepsin L precursor 0.0327 0.1589 0.3792
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.045 0.045
Brugia malayi cathepsin Z-like cysteine proteinase 0.0327 0.1589 0.1589
Brugia malayi Ets-domain containing protein 0.0059 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0167 0.0749 0.0749
Echinococcus multilocularis acetylcholinesterase 0.0801 0.4073 0.4073
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.0692 0.0692
Brugia malayi Cathepsin L-like cysteine proteinase 0.0925 0.4725 0.4725
Giardia lamblia Cathepsin B precursor 0.0327 0.1589 0.3792
Toxoplasma gondii cathepsin B 0.0823 0.419 0.5717
Toxoplasma gondii ABC1 family protein 0.008 0.0295 0.0403
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1422 0.7329 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0129 0.0129
Giardia lamblia Cathepsin L-like protease 0.0327 0.1589 0.3792
Loa Loa (eye worm) hypothetical protein 0.0801 0.4073 0.4073
Trypanosoma cruzi cysteine peptidase, putative 0.1422 0.7329 0.7279
Entamoeba histolytica hypothetical protein 0.0229 0.1077 0.1252
Mycobacterium ulcerans beta-lactamase 0.008 0.0295 0.4373
Giardia lamblia Cathepsin B precursor 0.0327 0.1589 0.3792
Plasmodium falciparum plasmepsin X 0.0042 0.0094 0.0129
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0057
Plasmodium vivax vivapain-2 0.1422 0.7329 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0085 0.0085
Plasmodium vivax vivapain-1 0.0824 0.4193 0.5721
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0078 0.0285 0.0285
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0135 0.0584 0.0584
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0295 0.4373
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0085 0.0085
Brugia malayi Papain family cysteine protease containing protein 0.0824 0.4193 0.4193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus multilocularis zinc finger transcription factor gli2 0.0309 0.1494 0.1494
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0327 0.1589 0.2168
Entamoeba histolytica cysteine protease, putative 0.0824 0.4193 0.5612
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1931 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0085 0.0085
Echinococcus granulosus cathepsin b 0.1931 1 1
Brugia malayi Zinc finger, C2H2 type family protein 0.0309 0.1494 0.1494
Echinococcus multilocularis cathepsin L 0.0327 0.1589 0.1589
Loa Loa (eye worm) hypothetical protein 0.0042 0.0094 0.0094
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0327 0.1589 0.2147
Schistosoma mansoni patched 1 0.0046 0.0119 0.0119
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0057 0.0057
Echinococcus granulosus acetylcholinesterase 0.0801 0.4073 0.4073
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0085 0.0085
Brugia malayi hypothetical protein 0.0127 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0167 0.0749 0.0749
Echinococcus multilocularis lysine specific demethylase 5A 0.0029 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.0327 0.1589 0.1967
Brugia malayi Cytochrome P450 family protein 0.0033 0.0046 0.0046
Echinococcus granulosus cysteine protease 0.0824 0.4193 0.4193
Echinococcus granulosus cathepsin L 0.0824 0.4193 0.4193
Echinococcus granulosus para nitrobenzyl esterase 0.0135 0.0584 0.0584
Giardia lamblia Cathepsin B precursor 0.0327 0.1589 0.3792
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0085 0.0085
Entamoeba histolytica cysteine proteinase, putative 0.1422 0.7329 1
Loa Loa (eye worm) cysteine protease 0.1422 0.7329 0.7329
Mycobacterium ulcerans hypothetical protein 0.008 0.0295 0.4373
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0108 0.0443 0.0443
Echinococcus granulosus cathepsin l1 0.0925 0.4725 0.4725
Schistosoma mansoni hypothetical protein 0.0075 0.0268 0.0268
Entamoeba histolytica cysteine proteinase, putative 0.0824 0.4193 0.5612
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0327 0.1589 0.3792
Giardia lamblia Cysteine protease 0.0327 0.1589 0.3792
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0085
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0327 0.1589 0.2168
Loa Loa (eye worm) hypothetical protein 0.0042 0.0094 0.0094
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0327 0.1589 0.1589
Echinococcus multilocularis geminin 0.0525 0.2627 0.2627
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1422 0.7329 0.7329
Echinococcus multilocularis lamin dm0 0.0027 0.0016 0.0016
Leishmania major cathepsin L-like protease 0.1422 0.7329 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1422 0.7329 1
Schistosoma mansoni cathepsin F (C01 family) 0.1422 0.7329 0.7329
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0085 0.0085
Entamoeba histolytica cysteine proteinase, putative 0.1422 0.7329 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0057 0.0057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0295 0.0472
Plasmodium falciparum plasmepsin IX 0.0042 0.0094 0.0129
Echinococcus granulosus cathepsin L cysteine protease 0.0824 0.4193 0.4193
Schistosoma mansoni neuroligin 3 (S09 family) 0.0135 0.0584 0.0584
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0327 0.1589 0.2168
Brugia malayi CHE-14 protein 0.0046 0.0119 0.0119
Giardia lamblia Hypothetical protein 0.0327 0.1589 0.3792
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0129 0.0129
Plasmodium vivax plasmepsin IV, putative 0.0177 0.0803 0.1095
Loa Loa (eye worm) hypothetical protein 0.0327 0.1589 0.1589
Trypanosoma cruzi major cysteine proteinase, putative 0.0327 0.1589 0.1432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1422 0.7329 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0268 0.0268
Loa Loa (eye worm) fli-1 protein 0.018 0.0818 0.0818

Activities

Activity type Activity value Assay description Source Reference
Decrease in MABP (functional) = 9 mmHg Decrease in MABP(mean arterial blood pressure) one hour after an oral dose of 10 mg/kg in normotensive monkeys ChEMBL. 1635057
Decrease in MABP (functional) = 16 mmHg Decrease in MABP(mean arterial blood pressure) 3 hours after an oral dose of 10 mg/kg in normotensive monkeys ChEMBL. 1635057
Decrease in MABP (functional) = 18 mmHg Decrease in MABP(mean arterial blood pressure) 2 hours after an oral dose of 10 mg/kg in normotensive monkeys ChEMBL. 1635057
IC50 (functional) = 0.32 nM Inhibitory activity of the compound against renin was determined ChEMBL. No reference
IC50 (functional) = 0.32 nM Inhibitory activity of the compound against renin was determined ChEMBL. No reference
IC50 (binding) = 0.36 nM In vitro inhibition of monkey renin. ChEMBL. 1635057
IC50 (binding) = 0.36 nM In vitro inhibitory activity against monkey plasma renin ChEMBL. No reference
IC50 (binding) = 0.36 nM In vitro inhibition of monkey renin. ChEMBL. 1635057
IC50 (binding) = 0.36 nM In vitro inhibitory activity against monkey plasma renin ChEMBL. No reference
IC50 (binding) = 0.37 nM Compound was evaluated for inhibition of plasma renin activity in monkey ChEMBL. 1635057
IC50 (binding) = 0.37 nM Compound was evaluated for inhibition of plasma renin activity in monkey ChEMBL. 1635057
IC50 (binding) = 0.57 nM Compound was evaluated for inhibition of plasma renin activity in human ChEMBL. 1635057
IC50 (binding) = 0.57 nM Compound was evaluated for inhibition of plasma renin activity in human ChEMBL. 1635057
IC50 (binding) = 1.96 nM Compound was evaluated for inhibition of plasma renin activity in dog ChEMBL. 1635057
IC50 (binding) = 1.96 nM Compound was evaluated for inhibition of plasma renin activity in dog ChEMBL. 1635057
IC50 (binding) = 199 nM Compound was evaluated for inhibition of plasma renin activity in rat ChEMBL. 1635057
IC50 (binding) = 199 nM Compound was evaluated for inhibition of plasma renin activity in rat ChEMBL. 1635057
IC50 (binding) = 1250 nM Inhibition of Bovine Cathepsin D ChEMBL. 1635057
IC50 (binding) = 1250 nM Inhibition of Bovine Cathepsin D ChEMBL. 1635057
IC50 (binding) = 202000 nM Inhibitory activity against pepsin. ChEMBL. 1635057
IC50 (binding) = 202000 nM Inhibitory activity against pepsin. ChEMBL. 1635057
logP (ADMET) = 3.01 Partition coefficient (logP) ChEMBL. 7739003
logP (ADMET) = 3.1 LogP value was evaluated in the in situ rat gut perfusion assay ChEMBL. No reference
Parent remaining at time (functional) = 88 % Enzymatic stability of the compound was measured at 90 min incubation period ChEMBL. 1635057
Parent remaining at time (functional) = 88 % Enzymatic stability of the compound was measured at 90 min incubation period ChEMBL. 1635057
Peff (ADMET) = 1.68 Effective permeability was evaluated for the compound. ChEMBL. 7739003
Permeability (ADMET) = 1.68 Tested for effective permeability across the rat intestinal membrane using mass balance analysis ChEMBL. No reference
pKa (ADMET) = 6.3 Acid dissociation constant of the compound ChEMBL. 7739003
pKa = 6.3 Tested for pKa value of the compound ChEMBL. No reference
Ratio (binding) = 3472 Relative inhibition of bovine cathepsin D and monkey renin ChEMBL. 1635057
S = 0.01 mg ml-1 Tested for aqueous solubility of the compound ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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