Detailed information for compound 516932

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 412.484 | Formula: C25H24N4O2
  • H donors: 1 H acceptors: 3 LogP: 2.97 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c2c3CCc4c(c3c3c(c2c2c1ccc(c2)C(=O)C)CNC3=O)cn(n4)C
  • InChi: 1S/C25H24N4O2/c1-4-9-29-20-8-5-14(13(2)30)10-16(20)22-17-11-26-25(31)23(17)21-15(24(22)29)6-7-19-18(21)12-28(3)27-19/h5,8,10,12H,4,6-7,9,11H2,1-3H3,(H,26,31)
  • InChiKey: KDPBUHMOJNVHAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens TEK tyrosine kinase, endothelial Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0252 0.031
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0098 0.1055
Brugia malayi steroid hormone receptor 0.001 0.0004 0.0004
Echinococcus multilocularis roundabout 2 0.0011 0.0011 0.0014
Brugia malayi Cathepsin L-like precursor 0.0016 0.005 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1967 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0004 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0121 0.0802 0.0802
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1967 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0016 0.0057
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0021 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0004 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Schistosoma mansoni nephrin 0.0011 0.0011 0.004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0004 0.0005
Brugia malayi Cathepsin L-like precursor 0.0016 0.005 0.005
Schistosoma mansoni vesicular amine transporter 0.0015 0.0038 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0274 0.139
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0116
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0057 0.0605
Echinococcus granulosus Ankyrin 0.0014 0.0036 0.0044
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Onchocerca volvulus Peroxidasin homolog 0.0406 0.2844 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0121 0.0802 0.0802
Entamoeba histolytica hypothetical protein 0.0035 0.0184 0.0935
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1967 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Toxoplasma gondii exonuclease III APE 0.0037 0.0201 0.1578
Echinococcus multilocularis protein jagged 1 0.0103 0.0674 0.0829
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Echinococcus granulosus neuroglian 0.0014 0.0035 0.0043
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0011 0.0011
Echinococcus granulosus fibropellin Ia 0.0103 0.0674 0.0829
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Echinococcus granulosus peroxidasin 0.041 0.287 0.3532
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0004 0.0014
Echinococcus granulosus neurogenic locus notch protein 0.0103 0.0674 0.0829
Echinococcus multilocularis neural cadherin 0.0103 0.0674 0.0829
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0098 0.1055
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0024 0.0181
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0004 0.0014
Leishmania major cathepsin L-like protease 0.0062 0.0377 0.2962
Onchocerca volvulus 0.0103 0.0674 0.237
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0201 0.1578
Loa Loa (eye worm) carboxylesterase 0.0012 0.0016 0.0016
Brugia malayi Cathepsin L-like precursor 0.0016 0.005 0.005
Echinococcus multilocularis neurogenic locus notch protein 4 0.0103 0.0674 0.0829
Loa Loa (eye worm) carboxylesterase 0.0012 0.0016 0.0016
Plasmodium falciparum glyoxalase I 0.0187 0.1272 1
Onchocerca volvulus Cathepsin L homolog 0.0016 0.005 0.0176
Brugia malayi proprotein convertase 2 0.0009 0.0001 0.0001
Echinococcus multilocularis cysteine protease 0.0016 0.005 0.0062
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0004 0.0005
Echinococcus granulosus neuroligin 0.0012 0.0016 0.002
Entamoeba histolytica hypothetical protein 0.0035 0.0184 0.0935
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0621 0.2181
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0098 0.1055
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0021 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0262 0.1809 0.6349
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Onchocerca volvulus Cathepsin L homolog 0.0016 0.005 0.0176
Onchocerca volvulus 0.0016 0.005 0.0176
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0004 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0098 0.0098
Onchocerca volvulus 0.0012 0.0016 0.0057
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0021 0.0106
Onchocerca volvulus Slit protein homolog 0.0103 0.0674 0.237
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0098 0.0501
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0121 0.0802 0.2813
Brugia malayi celfurPC protein 0.0009 0.0001 0.0001
Echinococcus multilocularis slit 2 protein 0.0103 0.0674 0.0829
Schistosoma mansoni neuroligin 3 (S09 family) 0.0012 0.0016 0.0057
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.005 0.0251
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0033
Loa Loa (eye worm) blistered cuticle protein 3 0.0404 0.2823 0.2823
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.005 0.0251
Mycobacterium tuberculosis Conserved protein TB27.3 0.0043 0.0243 0.2619
Echinococcus multilocularis geminin 0.0172 0.1167 0.1437
Loa Loa (eye worm) hypothetical protein 0.0262 0.1809 0.1809
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.0443 0.0545
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0243 0.1234
Brugia malayi Cadherin domain containing protein 0.0103 0.0674 0.0674
Brugia malayi Muscle positioning protein 4 0.0103 0.0674 0.0674
Schistosoma mansoni cell adhesion molecule 0.0011 0.0011 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0098
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0927 1
Brugia malayi Delta serrate ligand family protein 0.0103 0.0674 0.0674
Leishmania major hypothetical protein, conserved 0.001 0.0005 0.0034
Echinococcus granulosus RUN 0.0039 0.0213 0.0262
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 0.0011 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1967 1
Loa Loa (eye worm) subtilase 0.0304 0.211 0.211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0004 0.0004
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0114 0.0748 0.0921
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0377 0.6069
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0004 0.0005
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0011 0.0014 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0377 0.6069
Brugia malayi Animal haem peroxidase family protein 0.0406 0.2844 0.2844
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0423 0.0423
Brugia malayi Carboxylesterase family protein 0.0012 0.0016 0.0016
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0201 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0021 0.0106
Echinococcus granulosus jun protein 0.0081 0.0514 0.0633
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0252 0.031
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0004 0.0014
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0233 0.1605 0.1975
Onchocerca volvulus 0.001 0.0004 0.0014
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0012 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0252 0.0252
Brugia malayi Calcium binding EGF domain containing protein 0.0103 0.0674 0.0674
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0004 0.0004
Brugia malayi MH2 domain containing protein 0.0116 0.0764 0.0764
Loa Loa (eye worm) fibroinase 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0079 0.0499 0.0499
Schistosoma mansoni septate junction protein 0.0103 0.0674 0.2365
Schistosoma mansoni BC026374 protein (S09 family) 0.0012 0.0016 0.0057
Leishmania major cathepsin L-like protease 0.0016 0.005 0.0388
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0621 0.3159
Loa Loa (eye worm) hypothetical protein 0.0039 0.0213 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0021 0.0106
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0098 0.1055
Brugia malayi Subtilase family protein 0.0304 0.211 0.211
Onchocerca volvulus Tyrosine kinase homolog 0.0172 0.1164 0.4093
Schistosoma mansoni site-1 peptidase (S08 family) 0.0009 0.0001 0.0003
Brugia malayi Carboxylesterase family protein 0.0012 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0004 0.0004
Brugia malayi 4-hydroxyphenylpyruvate dioxygenase family protein 0.0043 0.0243 0.0243
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0098 0.0769
Schistosoma mansoni lipoxygenase 0.0163 0.1102 0.3867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0377 0.6069
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0377 0.2962
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.004 0.005
Brugia malayi Animal haem peroxidase family protein 0.0404 0.2823 0.2823
Loa Loa (eye worm) hypothetical protein 0.1406 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1967 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0016 0.0167
Echinococcus multilocularis jun protein 0.0081 0.0514 0.0633
Schistosoma mansoni hypothetical protein 0.0103 0.0674 0.2365
Brugia malayi Carboxylesterase family protein 0.0012 0.0016 0.0016
Leishmania major cysteine peptidase A (CPA) 0.0016 0.005 0.0388
Brugia malayi Cathepsin L-like precursor 0.0016 0.005 0.005
Mycobacterium tuberculosis Conserved protein 0.0043 0.0243 0.2619
Loa Loa (eye worm) 4-hydroxyphenylpyruvate dioxygenase 0.0043 0.0243 0.0243
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0004 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0184 0.0645
Onchocerca volvulus 0.0039 0.0213 0.0749
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0098 0.0769
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0213 0.0262
Schistosoma mansoni gynecophoral canal protein 0.0043 0.0243 0.0854
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0243 0.2619
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0012 0.0055
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.005 0.0062
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0098 0.1055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Onchocerca volvulus 0.0064 0.039 0.137
Loa Loa (eye worm) notch protein 0.0103 0.0674 0.0674
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.005 0.0251
Brugia malayi Carboxylesterase family protein 0.0068 0.0423 0.0423
Brugia malayi Doublecortin family protein 0.0039 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.005 0.0532
Leishmania major cathepsin L-like protease 0.0016 0.005 0.0388
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0304 0.211 0.7404
Echinococcus granulosus FTZ F1 alpha 0.001 0.0004 0.0005
Schistosoma mansoni notch 0.0103 0.0674 0.2365
Onchocerca volvulus Lactoylglutathione lyase homolog 0.0187 0.1272 0.4474
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0021 0.0106
Brugia malayi ecdysteroid receptor 0.001 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0103 0.0674 0.2365
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0213 0.1669
Mycobacterium ulcerans glyoxalase GloA 0.0043 0.0243 0.2619
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0377 0.6069
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0423 0.1483
Entamoeba histolytica cysteine protease, putative 0.0016 0.005 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0004 0.0004
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.1967 1
Brugia malayi EGF-like domain containing protein 0.0103 0.0674 0.0674
Brugia malayi Cadherin domain containing protein 0.0103 0.0674 0.0674
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0121 0.0802 0.0987
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0184 0.0184
Echinococcus multilocularis neurogenic locus notch protein 0.0103 0.0674 0.0829
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.005 0.0062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0004 0.0004
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0423 0.052
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0621 0.3156
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0057
Echinococcus multilocularis roundabout 2 0.0011 0.0011 0.0014
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0621 0.0621
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.005 0.0532
Loa Loa (eye worm) cysteine protease 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.005 0.0251
Onchocerca volvulus 0.0016 0.005 0.0176
Loa Loa (eye worm) animal heme peroxidase 0.0406 0.2844 0.2844
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0057 0.0441
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0011 0.0014 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0005 0.0034
Onchocerca volvulus 0.0012 0.0016 0.0057
Onchocerca volvulus Peroxidase homolog 0.0404 0.2823 0.9928
Echinococcus multilocularis 0.0009 0.0001 0.0001
Echinococcus multilocularis RUN 0.0039 0.0213 0.0262
Echinococcus multilocularis neuroendocrine convertase 2 0.0009 0.0001 0.0001
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 0.0011 0.004
Brugia malayi Fibronectin type III domain containing protein 0.0016 0.0045 0.0045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0098 0.0501
Brugia malayi neuroendocrine convertase 1 precursor 0.0009 0.0001 0.0001
Onchocerca volvulus 0.0167 0.1127 0.3963
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.005 0.0388
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0103 0.0674 0.0674
Echinococcus granulosus geminin 0.0172 0.1167 0.1437
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.005 0.005
Brugia malayi hypothetical protein 0.0016 0.0045 0.0045
Schistosoma mansoni site-1 peptidase (S08 family) 0.0009 0.0001 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0252 0.031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0252 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0243 0.1234
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0621 0.4882
Onchocerca volvulus 0.0103 0.0674 0.237
Echinococcus multilocularis neurogenic locus notch protein 0.0103 0.0674 0.0829
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0621 0.3156
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0621 0.4882
Schistosoma mansoni hypothetical protein 0.0121 0.0802 0.2813
Echinococcus multilocularis neuroglian 0.0011 0.0011 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0621 0.3156
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0098 0.0769
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0621 0.0621
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0184 0.0226
Echinococcus multilocularis fat cadherin tumor suppressor 0.0103 0.0674 0.0829
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0021 0.0026
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0201 0.1024
Brugia malayi nuclear hormone receptor 0.001 0.0004 0.0004
Echinococcus granulosus contactin 0.0011 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0005 0.0034
Entamoeba histolytica hypothetical protein 0.0035 0.0184 0.0935
Schistosoma mansoni rab6-interacting 0.0039 0.0213 0.0747
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0021 0.0106
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0004 0.0005
Echinococcus multilocularis roundabout 2 0.0022 0.0092 0.0113
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Loa Loa (eye worm) hypothetical protein 0.0068 0.0423 0.0423
Echinococcus granulosus protein jagged 1 0.0103 0.0674 0.0829
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0103 0.0674 0.237
Giardia lamblia High cysteine protein 0.0103 0.0674 0.3425
Loa Loa (eye worm) hypothetical protein 0.0039 0.0213 0.0213
Echinococcus granulosus roundabout 2 0.0011 0.0011 0.0014
Onchocerca volvulus 0.0016 0.005 0.0176
Onchocerca volvulus 0.0035 0.0184 0.0647
Onchocerca volvulus 0.0404 0.2823 0.9928
Schistosoma mansoni hypothetical protein 0.0103 0.0674 0.2365
Leishmania major cathepsin L-like protease 0.0062 0.0377 0.2962
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.005 0.0176
Echinococcus granulosus slit 2 protein 0.0103 0.0674 0.0829
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0272 0.0955
Schistosoma mansoni acetylcholinesterase 0.0012 0.0016 0.0057
Mycobacterium tuberculosis Carboxylesterase LipT 0.0012 0.0016 0.0167
Entamoeba histolytica hypothetical protein 0.0035 0.0184 0.0935
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0012 0.0016 0.002
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0011 0.0014 0.0049
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0213 0.0262
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0021 0.0106
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0009 0.0001 0.0003
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0011 0.0011 0.0014
Schistosoma mansoni notch 0.0103 0.0674 0.2365
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0201 0.1578
Mycobacterium ulcerans hypothetical protein 0.0043 0.0243 0.2619
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0201 0.1578
Brugia malayi hypothetical protein 0.0159 0.1069 0.1069
Echinococcus multilocularis membrane bound transcription factor site 1 0.0009 0.0001 0.0001
Toxoplasma gondii glyoxalase I, putative 0.0187 0.1272 1
Brugia malayi bZIP transcription factor family protein 0.0081 0.0514 0.0514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0012 0.0055
Mycobacterium ulcerans hypothetical protein 0.0043 0.0243 0.2619
Brugia malayi Immunoglobulin I-set domain containing protein 0.0184 0.125 0.125
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0004 0.0005
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0233 0.1605 0.1975
Brugia malayi EGF-like domain containing protein 0.0103 0.0674 0.0674
Schistosoma mansoni notch 0.0103 0.0674 0.2365
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.005 0.0532
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0057
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0011 0.0011 0.0014
Onchocerca volvulus 0.0023 0.0098 0.0346
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0339 0.266
Echinococcus granulosus protein jagged 2 0.0103 0.0674 0.0829
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0021 0.0163
Schistosoma mansoni thyroid hormone receptor 0.001 0.0004 0.0014
Echinococcus multilocularis netrin receptor unc 5 0.0018 0.0059 0.0073
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0014
Echinococcus multilocularis protein jagged 1 0.0103 0.0674 0.0829
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0213 0.0262
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0012 0.0016 0.002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0004 0.0014
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0033 0.0033
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0021 0.0163
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.005 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0252 0.0884
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0021 0.0026
Loa Loa (eye worm) Notch2 0.0103 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0121 0.0802 0.0987
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1967 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0004 0.0004
Schistosoma mansoni thyroid hormone receptor 0.001 0.0004 0.0014
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0098 0.1055
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0098 0.0098
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0057 1
Brugia malayi lactoylglutathione lyase 0.0187 0.1272 0.1272
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0184 0.1979
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0021 0.0106
Brugia malayi hypothetical protein 0.0039 0.0213 0.0213
Schistosoma mansoni hypothetical protein 0.0103 0.0674 0.2365
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0004 0.0014
Onchocerca volvulus 0.0039 0.0213 0.0749
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0377 0.6069
Onchocerca volvulus 0.0103 0.0674 0.237
Leishmania major cathepsin L-like protease 0.0016 0.005 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0187 0.1272 0.1272
Brugia malayi nuclear receptor NHR-88 0.001 0.0004 0.0004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0201 0.0248
Echinococcus granulosus delta-like protein 1 0.0103 0.0674 0.0829
Brugia malayi Serotonin receptor 0.0458 0.3211 0.3211
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0201 0.1024
Schistosoma mansoni hypothetical protein 0.0172 0.1167 0.4097
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0004 0.0014
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0021 0.0106
Schistosoma mansoni rab6-interacting 0.0039 0.0213 0.0747
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.005 0.0062
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0098 0.1055
Echinococcus granulosus notch 0.0103 0.0674 0.0829
Echinococcus granulosus roundabout 2 0.0011 0.0011 0.0014
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0184 0.0227
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0184 0.125 0.125
Echinococcus multilocularis fibropellin Ia 0.0103 0.0674 0.0829
Loa Loa (eye worm) hypothetical protein 0.041 0.287 0.287
Schistosoma mansoni cell adhesion molecule 0.0011 0.0011 0.004
Trichomonas vaginalis spcc417.12 protein, putative 0.0012 0.0016 0.0078
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0024 0.0181
Echinococcus granulosus Furin 1 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0014
Schistosoma mansoni laminin gamma-3 chain 0.0103 0.0674 0.2365
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.005 0.0251
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0004 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0098 0.1055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Brugia malayi Calcium binding EGF domain containing protein 0.0103 0.0674 0.0674
Schistosoma mansoni hypothetical protein 0.0039 0.0213 0.0747
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.005 0.0251
Echinococcus multilocularis neuroligin 0.0012 0.0016 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0201 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Brugia malayi Cathepsin L-like precursor 0.0016 0.005 0.005
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0201 0.3232
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0004 0.0004
Echinococcus granulosus acetylcholinesterase 0.0068 0.0423 0.052
Leishmania major cathepsin L-like protease 0.0016 0.005 0.0388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.005 0.0251
Mycobacterium ulcerans carboxylesterase, LipT 0.0012 0.0016 0.0167
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0004 0.0014
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0054 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Toxoplasma gondii glyoxalase family protein 0.0043 0.0243 0.1908
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0764 0.0764
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0098 0.1055
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.005 0.0062
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Leishmania major protein kinase, putative 0.0013 0.0024 0.0181
Onchocerca volvulus 0.0103 0.0674 0.237
Schistosoma mansoni hypothetical protein 0.0121 0.0802 0.2813
Brugia malayi hypothetical protein 0.0039 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0981 0.0981
Leishmania major glyoxalase I,trypanothione-dependent glyoxalase I 0.0187 0.1272 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Brugia malayi notch-like transmembrane receptor 0.0103 0.0674 0.0674
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0187 0.1272 1
Echinococcus multilocularis Immunoglobulin 0.0011 0.0014 0.0017
Schistosoma mansoni nuclear hormone receptor 0.001 0.0004 0.0014
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0927 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0033 0.0041
Brugia malayi EGF-like domain containing protein 0.0103 0.0674 0.0674
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1967 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0004 0.0004
Onchocerca volvulus 0.0012 0.0016 0.0057
Brugia malayi hypothetical protein 0.0404 0.2823 0.2823
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.005 0.0254
Brugia malayi Cathepsin L-like precursor 0.0011 0.0012 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0004 0.0005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1144 0.8125 1
Brugia malayi Calcium binding EGF domain containing protein 0.0103 0.0674 0.0674
Schistosoma mansoni slit 0.0103 0.0674 0.2365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Echinococcus granulosus acetylcholinesterase 0.0068 0.0423 0.052
Echinococcus multilocularis cysteine protease 0.0016 0.005 0.0062
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0098 0.1055
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Echinococcus multilocularis Ankyrin 0.0014 0.0036 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Echinococcus granulosus GPCR family 2 0.0121 0.0802 0.0987
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0016 0.0057
Schistosoma mansoni peroxidasin 0.0407 0.2849 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 0.0011 0.0014
Brugia malayi EGF-like domain containing protein 0.0103 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0282 0.2215
Brugia malayi Carboxylesterase family protein 0.0012 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0159 0.1069 0.1069
Brugia malayi cathepsin L-like precursor 0.0011 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0103 0.0674 0.2365
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0201 0.102
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0004 0.0004
Echinococcus granulosus Immunoglobulin 0.0011 0.0014 0.0017
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0243 0.2619
Echinococcus multilocularis neurogenic locus protein delta 0.0103 0.0674 0.0829
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0383 0.2677 0.2677
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0004 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0004 0.0004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0201 0.2166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Echinococcus multilocularis para nitrobenzyl esterase 0.0012 0.0016 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Onchocerca volvulus 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0004 0.0004
Echinococcus granulosus neurogenic locus notch protein 0.0103 0.0674 0.0829
Mycobacterium tuberculosis Cadmium inducible protein CadI 0.0043 0.0243 0.2619
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0004 0.0005
Schistosoma mansoni ap endonuclease 0.0037 0.0201 0.0707
Echinococcus granulosus BC026374 protein S09 family 0.0012 0.0016 0.002
Schistosoma mansoni neuroglian 0.0011 0.0011 0.004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0004 0.0014
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0057 0.0441
Onchocerca volvulus 0.0016 0.005 0.0176
Brugia malayi Peroxidasin 0.041 0.287 0.287
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.005 0.0388
Brugia malayi Blistered cuticle protein 3 0.0404 0.2823 0.2823
Loa Loa (eye worm) carboxylesterase 0.0068 0.0423 0.0423
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0021 0.0106
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Schistosoma mansoni loxhd1 0.0039 0.0213 0.0747
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0024 0.0181
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0021 0.0106
Schistosoma mansoni notch 0.0104 0.0676 0.2374
Echinococcus granulosus furin 0.0009 0.0001 0.0001
Plasmodium falciparum glyoxalase I 0.0043 0.0243 0.1908
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0009 0.0001 0.0001
Brugia malayi PAS domain containing protein 0.0047 0.0272 0.0272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1967 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0252 0.031
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Echinococcus granulosus protein jagged 1 0.0103 0.0674 0.0829
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Onchocerca volvulus Cathepsin F homolog 0.0016 0.005 0.0176
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0764 0.0764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.005 0.0251
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0201 0.5
Leishmania major cathepsin L-like protease 0.0062 0.0377 0.2962
Loa Loa (eye worm) animal heme peroxidase 0.0404 0.2823 0.2823
Loa Loa (eye worm) latrophilin receptor protein 2 0.0121 0.0802 0.0802
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0213 0.0262
Onchocerca volvulus 0.0012 0.0021 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Echinococcus multilocularis protein jagged 2 0.0103 0.0674 0.0829
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0621 0.3156
Echinococcus granulosus death domain containing protein 0.0014 0.0033 0.0041
Onchocerca volvulus 0.0016 0.005 0.0176
Schistosoma mansoni notch 0.0103 0.0674 0.2365
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0057
Onchocerca volvulus Putative cubilin 0.0103 0.0674 0.237
Loa Loa (eye worm) animal heme peroxidase 0.0404 0.2823 0.2823
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Brugia malayi GCC2 and GCC3 family protein 0.0103 0.0674 0.0674
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0621 0.2185
Echinococcus granulosus X box binding protein 1 0.0293 0.2031 0.25
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0057 0.0605
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0377 0.2962
Brugia malayi Cathepsin L-like precursor 0.0016 0.005 0.005
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Plasmodium vivax vivapain-2 0.0016 0.005 0.0388
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0274 0.139
Onchocerca volvulus 0.0012 0.0016 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0377 0.6069
Echinococcus granulosus protein jagged 2 0.0103 0.0674 0.0829
Schistosoma mansoni ap endonuclease 0.0037 0.0201 0.0707
Brugia malayi EGF-like domain containing protein 0.0103 0.0674 0.0674
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0927 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0024 0.0181
Schistosoma mansoni 4-hydroxyphenylpyruvate dioxygenase 0.0043 0.0243 0.0854
Mycobacterium tuberculosis Conserved protein 0.0043 0.0243 0.2619
Onchocerca volvulus Neurogenic locus notch homolog 0.0104 0.0676 0.2379
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0213 0.0262
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0377 0.6069
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.005 0.0254
Onchocerca volvulus Peroxidase homolog 0.0404 0.2823 0.9928
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0021 0.0021
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0021 0.0163
Onchocerca volvulus Putative protein 0.0043 0.0243 0.0856
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0621 0.4882
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0068 0.0423 0.0423
Plasmodium vivax glyoxalase I, putative 0.0043 0.0243 0.1908
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0016 0.0167
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0103 0.0674 0.2365
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.0443 0.0545
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0098 0.1055
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0187 0.1272 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0004 0.0004
Onchocerca volvulus Peroxidasin homolog 0.0406 0.2844 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Loa Loa (eye worm) proprotein convertase 2 0.0009 0.0001 0.0001
Schistosoma mansoni coup transcription factor 0.001 0.0004 0.0014
Echinococcus multilocularis notch 0.0103 0.0674 0.0829
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.005 0.0532
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0621 0.0765
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0036 0.0125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0201 0.1578
Schistosoma mansoni lipoxygenase 0.0233 0.1605 0.5632
Echinococcus multilocularis GPCR, family 2 0.0121 0.0802 0.0987
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0009 0.0001 0.0003
Schistosoma mansoni netrin receptor unc5 0.0018 0.0059 0.0208
Brugia malayi hypothetical protein 0.0064 0.039 0.039
Leishmania major protein kinase, putative 0.0013 0.0024 0.0181
Echinococcus granulosus cathepsin l1 0.0016 0.005 0.0062
Loa Loa (eye worm) POT family protein 0.0087 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0377 0.2962
Onchocerca volvulus 0.0404 0.2823 0.9928
Mycobacterium ulcerans hypothetical protein 0.0043 0.0243 0.2619
Brugia malayi hypothetical protein 0.0035 0.0184 0.0184
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0184 0.0226
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1967 1
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0033 0.0116
Schistosoma mansoni single-minded 0.0047 0.0272 0.0955
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0621 0.3156
Brugia malayi Protein kinase domain containing protein 0.0014 0.0035 0.0035
Brugia malayi EGF-like domain containing protein 0.0103 0.0674 0.0674
Schistosoma mansoni hypothetical protein 0.0121 0.0802 0.2813
Onchocerca volvulus 0.0016 0.005 0.0176
Mycobacterium ulcerans hypothetical protein 0.0043 0.0243 0.2619
Loa Loa (eye worm) endoprotease bli-4 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0293 0.2031 0.713
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus multilocularis Furin 1 0.0009 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0213 0.0262
Schistosoma mansoni cell adhesion molecule 0.0019 0.0071 0.025
Loa Loa (eye worm) animal heme peroxidase 0.0404 0.2823 0.2823
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0004 0.0004
Schistosoma mansoni gliotactin 0.0012 0.0016 0.0057
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.005 0.0062
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0004 0.0014
Schistosoma mansoni nephrin 0.0018 0.0066 0.023
Schistosoma mansoni hypothetical protein 0.0172 0.1167 0.4097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Echinococcus granulosus twitchin 0.0014 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0012
Echinococcus multilocularis neuroglian 0.0014 0.0035 0.0043
Mycobacterium ulcerans hypothetical protein 0.0023 0.0098 0.1055
Echinococcus granulosus roundabout 2 0.0022 0.0092 0.0113
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0201 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.005 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0377 0.6069
Echinococcus granulosus single minded 2 0.0035 0.0184 0.0227
Schistosoma mansoni notch 0.0103 0.0674 0.2365
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0061
Brugia malayi Carboxylesterase family protein 0.0068 0.0423 0.0423
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.1967 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0098 0.0501
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0011 0.0014 0.0014
Brugia malayi Animal haem peroxidase family protein 0.0404 0.2823 0.2823
Toxoplasma gondii EGF family domain-containing protein 0.0103 0.0674 0.5294
Echinococcus granulosus netrin receptor unc 5 0.0018 0.0059 0.0073
Brugia malayi Uncoordinated protein 44 0.0014 0.0033 0.0033
Echinococcus granulosus cathepsin l1 0.0011 0.0012 0.0014
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0021 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0377 0.6069
Schistosoma mansoni kinase 0.0049 0.0283 0.0994
Schistosoma mansoni hypothetical protein 0.0103 0.0674 0.2365
Onchocerca volvulus 0.0404 0.2823 0.9928
Schistosoma mansoni hypothetical protein 0.0103 0.0674 0.2365
Brugia malayi EGF-like domain containing protein 0.0103 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.005 0.0388
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0098
Brugia malayi latrophilin 2 splice variant baaae 0.0262 0.1809 0.1809
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0213 0.0213
Leishmania major cathepsin L-like protease 0.0016 0.005 0.0388
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0033 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0004 0.0004
Schistosoma mansoni polycystin 1-related 0.0039 0.0213 0.0747
Loa Loa (eye worm) ctsf protein 0.0016 0.005 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0004 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0004 0.0005
Brugia malayi Death domain containing protein 0.0014 0.0033 0.0033
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0016 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0004 0.0004
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0423 0.052
Echinococcus granulosus membrane bound transcription factor site 1 0.0009 0.0001 0.0001
Brugia malayi POT family protein 0.0087 0.0557 0.0557
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.005 0.0062
Echinococcus multilocularis X box binding protein 1 0.0293 0.2031 0.25
Echinococcus granulosus para nitrobenzyl esterase 0.0012 0.0016 0.002
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0012 0.004
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0004 0.0005
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.005 0.0388
Plasmodium vivax glyoxalase I, putative 0.0187 0.1272 1
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Echinococcus granulosus neurogenic locus notch protein 4 0.0103 0.0674 0.0829
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Onchocerca volvulus 0.0103 0.0674 0.237
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0201 0.2166
Brugia malayi Cathepsin L-like precursor 0.0011 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1967 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0201 0.1578
Brugia malayi Animal haem peroxidase family protein 0.0404 0.2823 0.2823
Echinococcus granulosus neuroglian 0.0011 0.0011 0.0014
Schistosoma mansoni cell polarity protein 0.0103 0.0674 0.2365
Schistosoma mansoni hypothetical protein 0.0035 0.0184 0.0645
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0009 0.0001 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0004 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0377 0.6069
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0009 0.0001 0.0001
Onchocerca volvulus 0.0011 0.0012 0.0041
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0004 0.0005
Echinococcus multilocularis BC026374 protein (S09 family) 0.0012 0.0016 0.002
Mycobacterium ulcerans hypothetical protein 0.0043 0.0243 0.2619
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Onchocerca volvulus 0.0012 0.0016 0.0057
Mycobacterium ulcerans hypothetical protein 0.0043 0.0243 0.2619
Loa Loa (eye worm) hypothetical protein 0.0121 0.0802 0.0802
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.005 0.0251
Echinococcus granulosus neurogenic locus protein delta 0.0103 0.0674 0.0829
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.005 0.0176
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.005 0.0251
Echinococcus multilocularis peroxidasin 0.041 0.287 0.3532
Onchocerca volvulus Chorion peroxidase homolog 0.0404 0.2823 0.9928
Mycobacterium leprae Possible regulatory protein 0.0012 0.0021 0.0224
Brugia malayi hypoxia-induced factor 1 0.0146 0.0981 0.0981
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0004 0.0014
Brugia malayi Animal haem peroxidase family protein 0.0404 0.2823 0.2823
Echinococcus granulosus neural cadherin 0.0103 0.0674 0.0829
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Schistosoma mansoni jun-related protein 0.0066 0.0406 0.1424
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0036
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 0.0011 0.0014
Schistosoma mansoni peroxidasin 0.0404 0.2823 0.9908
Trypanosoma brucei polo-like protein kinase 0.0096 0.0621 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0012 0.0016 0.0078
Mycobacterium ulcerans glyoxalase GloA 0.0043 0.0243 0.2619
Echinococcus multilocularis Immunoglobulin 0.0011 0.0014 0.0017
Giardia lamblia Kinase, PLK 0.0096 0.0621 0.3159
Echinococcus granulosus neuroendocrine convertase 2 0.0009 0.0001 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0514 0.0633
Brugia malayi Calcitonin receptor-like protein seb-1 0.0383 0.2677 0.2677
Plasmodium vivax vivapain-2 0.0016 0.005 0.0388
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0423 0.052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0014
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0114 0.0748 0.0921
Echinococcus granulosus defective proboscis extension response 0.0011 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Onchocerca volvulus 0.0016 0.005 0.0176
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0621 0.0765
Schistosoma mansoni furin-1 (S08 family) 0.0009 0.0001 0.0003
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0009 0.0001 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0252 0.0252
Onchocerca volvulus Dual oxidase homolog 0.0404 0.2823 0.9928
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0061
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0213 0.1669
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0377 0.2962
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0201 0.102
Toxoplasma gondii cathepsin CPL 0.0016 0.005 0.0388
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.005 0.0251
Loa Loa (eye worm) hypothetical protein 0.0103 0.0674 0.0674
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0252 0.0884
Echinococcus multilocularis neurogenic locus protein delta 0.0103 0.0674 0.0829
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0012 0.0059
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1144 0.8125 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0621 0.3156
Schistosoma mansoni hypothetical protein 0.0066 0.0406 0.1424
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0514 0.0633
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0377 0.6069
Brugia malayi endoprotease bli-4 precursor 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0404 0.2823 0.2823
Brugia malayi hypothetical protein 0.0012 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0004 0.0004
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0423 0.052
Mycobacterium ulcerans biphenyl-2,3-diol 1,2-dioxygenase 0.0043 0.0243 0.2619
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0621 0.3156
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3 nM Inhibition of VEGFR2 (unknown origin) ChEMBL. 18343109
IC50 (binding) = 3 nM Inhibition of VEGFR2 (unknown origin) ChEMBL. 18343109
IC50 (binding) = 272 nM Inhibition of TIE2 (unknown origin) ChEMBL. 18343109
IC50 (binding) = 272 nM Inhibition of TIE2 (unknown origin) ChEMBL. 18343109

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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