Detailed information for compound 524664

Basic information

Technical information
  • TDR Targets ID: 524664
  • Name: 6-methoxy-N-[(E)-[4-(pyrrolidin-1-ylmethyl)ph enyl]methylideneamino]quinolin-4-amine
  • MW: 360.452 | Formula: C22H24N4O
  • H donors: 1 H acceptors: 1 LogP: 4.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(N/N=C/c1ccc(cc1)CN1CCCC1)ccn2
  • InChi: 1S/C22H24N4O/c1-27-19-8-9-21-20(14-19)22(10-11-23-21)25-24-15-17-4-6-18(7-5-17)16-26-12-2-3-13-26/h4-11,14-15H,2-3,12-13,16H2,1H3,(H,23,25)/b24-15+
  • InChiKey: MNYYSLSKYQFZJE-BUVRLJJBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methoxy-N-[(E)-[4-(pyrrolidin-1-ylmethyl)phenyl]methyleneamino]quinolin-4-amine
  • 6-methoxy-N-[(E)-[4-(1-pyrrolidinylmethyl)phenyl]methyleneamino]-4-quinolinamine
  • (6-methoxy-4-quinolyl)-[(E)-[4-(pyrrolidinomethyl)benzylidene]amino]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0105316 0.0955399 0.0982234
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Schistosoma mansoni amine GPCR 0.0105316 0.0955399 0.0982234
Schistosoma mansoni synaptic glycoprotein sc2 related 0.00773954 0.0578016 0.0584001
Echinococcus granulosus allatostatin A receptor 0.0105316 0.0955399 0.124314
Brugia malayi Melatonin receptor type 1A 0.0105316 0.0955399 0.0933103
Schistosoma mansoni synaptic glycoprotein sc2 related 0.00773954 0.0578016 0.0584001
Loa Loa (eye worm) G-protein coupled receptor 0.0105316 0.0955399 0.0955399
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105316 0.0955399 0.0982234
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00591411 0.0331282 0.0323636
Schistosoma mansoni amine GPCR 0.0105316 0.0955399 0.0982234
Echinococcus multilocularis protein kinase c iota type 0.00460472 0.01543 0.0169316
Echinococcus multilocularis serotonin receptor 0.0150625 0.156782 0.201446
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0105316 0.0955399 0.124314
Echinococcus granulosus rhodopsin orphan GPCR 0.0105316 0.0955399 0.124314
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00391807 0.00614885 0.00389365
Echinococcus granulosus rhodopsin orphan GPCR 0.0105316 0.0955399 0.124314
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) glutamate receptor 2 0.00389483 0.00583475 0.00583475
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.077447 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0105316 0.0955399 0.0982234
Echinococcus multilocularis nervana 2 0.00877747 0.0718308 0.0905546
Schistosoma mansoni sodium/chloride dependent transporter 0.00401951 0.00751994 0.00534049
Echinococcus multilocularis sodium and chloride dependent glycine 0.00401951 0.00751994 0.00660625
Echinococcus multilocularis G protein coupled receptor 139 0.0105316 0.0955399 0.121503
Brugia malayi Cytochrome P450 family protein 0.013566 0.136555 0.134426
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0105316 0.0955399 0.121503
Brugia malayi Pepsin A precursor 0.00591411 0.0331282 0.0307448
Echinococcus multilocularis G-protein coupled receptor, putative 0.0105316 0.0955399 0.121503
Echinococcus granulosus sodium:myo inositol cotransporter 0.0142848 0.14627 0.190324
Onchocerca volvulus 0.0118844 0.113826 0.411278
Schistosoma mansoni hypothetical protein 0.0105316 0.0955399 0.0982234
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00401951 0.00751994 0.00534049
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Loa Loa (eye worm) hypothetical protein 0.00591411 0.0331282 0.0331282
Loa Loa (eye worm) hypothetical protein 0.0110634 0.102729 0.102729
Loa Loa (eye worm) hypothetical protein 0.00773954 0.0578016 0.0578016
Giardia lamblia Kinase, AGC PKA 0.00890479 0.0735518 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00391807 0.00614885 0.00614885
Schistosoma mansoni sodium/chloride dependent transporter 0.00414684 0.00924096 0.00715659
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105316 0.0955399 0.0982234
Brugia malayi aspartic protease BmAsp-2, identical 0.00591411 0.0331282 0.0307448
Echinococcus granulosus sodium channel protein 0.00363343 0.00230155 0.00299472
Schistosoma mansoni neuropeptide F-like receptor 0.0105316 0.0955399 0.0982234
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0105316 0.0955399 0.124314
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Echinococcus granulosus neuropeptides capa receptor 0.0105316 0.0955399 0.124314
Echinococcus multilocularis Glutaredoxin protein 5 0.00877747 0.0718308 0.0905546
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.00773954 0.0578016 0.0519723
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0105316 0.0955399 0.0982234
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00401951 0.00751994 0.00534049
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.007091 0.0490357 0.0465503
Trichomonas vaginalis AGC family protein kinase 0.013474 0.135312 0.129962
Echinococcus multilocularis 0.00365601 0.00260672 0.000192751
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Echinococcus granulosus sphingosine kinase 1 0.0603223 0.768535 1
Echinococcus multilocularis glutamate receptor 2 0.00463371 0.0158218 0.017443
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00401951 0.00751994 0.00534049
Brugia malayi GnHR receptor homolog 0.0105316 0.0955399 0.0933103
Echinococcus multilocularis hyperpolarization activated cyclic 0.00391807 0.00614885 0.00481648
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.077447 1 1
Brugia malayi follicle stimulating hormone receptor 0.0105316 0.0955399 0.0933103
Echinococcus granulosus rhodopsin orphan GPCR 0.0105316 0.0955399 0.124314
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0105316 0.0955399 0.0933103
Loa Loa (eye worm) calcium channel 0.0106529 0.0971799 0.0971799
Echinococcus multilocularis g protein coupled receptor 0.0105316 0.0955399 0.121503
Echinococcus multilocularis sodium channel protein 0.00726128 0.0513373 0.0638033
Schistosoma mansoni adenoreceptor 0.0105316 0.0955399 0.0982234
Plasmodium falciparum plasmepsin X 0.00591411 0.0331282 0.090238
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0105316 0.0955399 0.121503
Entamoeba histolytica hypothetical protein, conserved 0.0603223 0.768535 0.764908
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00401951 0.00751994 0.00978477
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00391807 0.00614885 0.00614885
Schistosoma mansoni glutamate receptor NMDA 0.00925169 0.0782406 0.0799683
Echinococcus granulosus tm gpcr rhodopsin 0.0105316 0.0955399 0.124314
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.00463371 0.0158218 0.0205869
Brugia malayi Protein kinase domain containing protein 0.013474 0.135312 0.13318
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00401951 0.00751994 0.00534049
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.00460472 0.01543 0.0169316
Schistosoma mansoni cathepsin D (A01 family) 0.0737555 0.950104 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0105316 0.0955399 0.124314
Echinococcus granulosus neuropeptide receptor 0.0105316 0.0955399 0.124314
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105316 0.0955399 0.0982234
Brugia malayi hypothetical protein 0.0105316 0.0955399 0.0933103
Brugia malayi AKH receptor 0.0105316 0.0955399 0.0933103
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.00401951 0.00751994 0.00660625
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00463371 0.0158218 0.0205869
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0105316 0.0955399 0.121503
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) hypothetical protein 0.00545805 0.0269639 0.0269639
Echinococcus granulosus cytochrome P450 2K1 0.00365601 0.00260672 0.0033918
Echinococcus granulosus Glutaredoxin protein 5 0.00877747 0.0718308 0.0934645
Brugia malayi Cytochrome P450 family protein 0.00365601 0.00260672 0.000148026
Entamoeba histolytica protein kinase, putative 0.0133822 0.13407 0.1205
Trichomonas vaginalis AGC family protein kinase 0.00460472 0.01543 0.00933854
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00391807 0.00614885 0.00389365
Echinococcus granulosus neuropeptide s receptor 0.0105316 0.0955399 0.124314
Loa Loa (eye worm) hypothetical protein 0.00401951 0.00751994 0.00751994
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0105316 0.0955399 0.121503
Loa Loa (eye worm) cytochrome P450 family protein 0.013566 0.136555 0.136555
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.00401951 0.00751994 0.00660625
Schistosoma mansoni sodium/chloride dependent transporter 0.0236786 0.273241 0.285742
Brugia malayi Cation transporter family protein 0.0118844 0.113826 0.111641
Loa Loa (eye worm) hypothetical protein 0.0236786 0.273241 0.273241
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Schistosoma mansoni serine/threonine protein kinase 0.00460472 0.01543 0.0136875
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0106529 0.0971799 0.123644
Schistosoma mansoni alpha-1 adrenergic receptor 0.0105316 0.0955399 0.0982234
Echinococcus granulosus neuropeptide Y receptor 0.0105316 0.0955399 0.124314
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.00890479 0.0735518 0.232682
Loa Loa (eye worm) hypothetical protein 0.0134394 0.134844 0.134844
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Echinococcus multilocularis glutamate receptor NMDA 0.00630925 0.0384691 0.0470059
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Echinococcus granulosus g protein coupled receptor 0.0105316 0.0955399 0.124314
Loa Loa (eye worm) hypothetical protein 0.0106529 0.0971799 0.0971799
Brugia malayi Cytochrome P450 family protein 0.00520669 0.0235664 0.0211594
Toxoplasma gondii aspartyl protease ASP1 0.0250151 0.291306 0.291306
Loa Loa (eye worm) serotonin transporter b 0.0236786 0.273241 0.273241
Plasmodium falciparum plasmepsin V 0.00591411 0.0331282 0.090238
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00391807 0.00614885 0.00389365
Schistosoma mansoni myosin xvIII 0.0105316 0.0955399 0.0982234
Echinococcus granulosus hyperpolarization activated cyclic 0.00391807 0.00614885 0.00800074
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.00773954 0.0578016 0.0752101
Trichomonas vaginalis AGC family protein kinase 0.013474 0.135312 0.129962
Schistosoma mansoni amine GPCR 0.0105316 0.0955399 0.0982234
Echinococcus granulosus protein kinase c iota type 0.00460472 0.01543 0.0200771
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0105316 0.0955399 0.0933103
Echinococcus multilocularis neuropeptide receptor 0.0105316 0.0955399 0.121503
Echinococcus granulosus neuropeptide receptor A26 0.0105316 0.0955399 0.124314
Leishmania major lanosterol 14-alpha-demethylase, putative 0.00365601 0.00260672 0.000305875
Schistosoma mansoni cytochrome P450 0.00365601 0.00260672 0.00015582
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.00773954 0.0578016 0.177182
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0155687 0.163624 0.212904
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Entamoeba histolytica steroid 5-alpha reductase, putative 0.077447 1 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.00401951 0.00751994 0.5
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.00773954 0.0578016 0.0722415
Echinococcus granulosus glutamate receptor 2 0.00463371 0.0158218 0.0205869
Plasmodium vivax aspartyl protease, putative 0.00591411 0.0331282 0.090238
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.00773954 0.0578016 0.0519723
Echinococcus multilocularis nervana 2 0.00877747 0.0718308 0.0905546
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.00773954 0.0578016 0.0578016
Schistosoma mansoni glutamate receptor AMPA 0.00389483 0.00583475 0.00356219
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Brugia malayi hypothetical protein 0.0105316 0.0955399 0.0933103
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0105316 0.0955399 0.0933103
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00401951 0.00751994 0.00507336
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0250151 0.291306 0.286921
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.00773954 0.0578016 0.0553391
Schistosoma mansoni inositol transporter 0.0142848 0.14627 0.151756
Schistosoma mansoni serine/threonine-protein kinase 0.00899664 0.0747932 0.0763304
Brugia malayi neuropeptide F receptor 0.0105316 0.0955399 0.0933103
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.00460472 0.01543 0.01543
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105316 0.0955399 0.0982234
Echinococcus multilocularis glutamate receptor 2 0.00389483 0.00583475 0.00440647
Toxoplasma gondii AGC kinase 0.0133822 0.13407 0.13407
Echinococcus granulosus neuropeptide FF receptor 2 0.0105316 0.0955399 0.124314
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.00460472 0.01543 0.01543
Echinococcus multilocularis voltage gated potassium channel 0.00545805 0.0269639 0.0319875
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00401951 0.00751994 0.00534049
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.00460472 0.01543 0.0169316
Plasmodium falciparum plasmepsin III 0.00591411 0.0331282 0.090238
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.00391807 0.00614885 0.00800074
Brugia malayi sulfakinin receptor protein 0.0105316 0.0955399 0.0933103
Toxoplasma gondii hypothetical protein 0.00401951 0.00751994 0.00751994
Echinococcus granulosus nmda type glutamate receptor 0.00775055 0.0579505 0.0754039
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0105316 0.0955399 0.0982234
Brugia malayi p70 ribosomal S6 kinase beta 0.0133822 0.13407 0.131936
Plasmodium vivax aspartyl protease, putative 0.00591411 0.0331282 0.090238
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0106529 0.0971799 0.126448
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.00890479 0.0735518 0.0957038
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0105316 0.0955399 0.121503
Mycobacterium leprae putative cytochrome p450 0.00365601 0.00260672 0.5
Schistosoma mansoni glutamate receptor AMPA 0.00389483 0.00583475 0.00356219
Echinococcus granulosus Protein kinase C brain isozyme 0.00460472 0.01543 0.0200771
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105316 0.0955399 0.0982234
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00401951 0.00751994 0.00507336
Echinococcus multilocularis g protein coupled receptor 0.0105316 0.0955399 0.121503
Echinococcus granulosus tm gpcr rhodopsin 0.0456435 0.570129 0.741839
Echinococcus multilocularis sodium and chloride dependent glycine 0.00401951 0.00751994 0.00660625
Echinococcus multilocularis neuropeptide s receptor 0.0105316 0.0955399 0.121503
Loa Loa (eye worm) CYP4Cod1 0.00520669 0.0235664 0.0235664
Echinococcus granulosus nmda type glutamate receptor 0.00704812 0.0484562 0.06305
Echinococcus multilocularis neuropeptides capa receptor 0.0105316 0.0955399 0.121503
Schistosoma mansoni neuropeptide f receptor 76f 0.0105316 0.0955399 0.0982234
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0106529 0.0971799 0.123644
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00401951 0.00751994 0.00507336
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0106529 0.0971799 0.0949543
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.01378 0.139447 0.134123
Echinococcus granulosus rhodopsin orphan GPCR 0.0105316 0.0955399 0.124314
Toxoplasma gondii cytochrome p450 superfamily protein 0.00365601 0.00260672 0.00260672
Brugia malayi Serotonin receptor 0.0105316 0.0955399 0.0933103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105316 0.0955399 0.0982234
Trichomonas vaginalis AGC family protein kinase 0.013474 0.135312 0.129962
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00591411 0.0331282 0.0323636
Echinococcus multilocularis neuropeptide receptor 0.0105316 0.0955399 0.121503
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0250151 0.291306 0.291306
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0250151 0.291306 0.37904
Echinococcus granulosus sodium:glucose cotransporter 0.0142848 0.14627 0.190324
Schistosoma mansoni voltage-gated cation channel 0.0106529 0.0971799 0.0999539
Brugia malayi Protein kinase domain containing protein 0.00460472 0.01543 0.0130029
Echinococcus multilocularis sex peptide receptor 0.0105316 0.0955399 0.121503
Loa Loa (eye worm) AGC/NDR protein kinase 0.00460472 0.01543 0.01543
Loa Loa (eye worm) AGC/AKT protein kinase 0.013474 0.135312 0.135312
Schistosoma mansoni opsin-like receptor 0.0105316 0.0955399 0.0982234
Schistosoma mansoni biogenic amine receptor 0.0105316 0.0955399 0.0982234
Echinococcus multilocularis solute carrier family 5 0.0142848 0.14627 0.187725
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0044774 0.013709 0.00760688
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.077447 1 1
Leishmania major cytochrome p450-like protein 0.00365601 0.00260672 0.000305875
Loa Loa (eye worm) hypothetical protein 0.00401951 0.00751994 0.00751994
Brugia malayi hypothetical protein 0.00591411 0.0331282 0.0307448
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Echinococcus multilocularis allatostatin A receptor 0.0105316 0.0955399 0.121503
Schistosoma mansoni amine GPCR 0.0105316 0.0955399 0.0982234
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0105316 0.0955399 0.121503
Schistosoma mansoni voltage-gated potassium channel 0.00545805 0.0269639 0.0258587
Echinococcus multilocularis protein kinase c epsilon type 0.00460472 0.01543 0.0169316
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0142848 0.14627 0.187725
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00401951 0.00751994 0.00534049
Plasmodium vivax polyprenol reductase, putative 0.00773954 0.0578016 0.177182
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Echinococcus granulosus nervana 2 0.00877747 0.0718308 0.0934645
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.00460472 0.01543 0.0200771
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105316 0.0955399 0.121503
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Loa Loa (eye worm) hypothetical protein 0.0250151 0.291306 0.291306
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0250151 0.291306 0.291306
Echinococcus granulosus peptide allatostatin:somatostatin 0.0105316 0.0955399 0.124314
Echinococcus multilocularis hyperpolarization activated cyclic 0.00391807 0.00614885 0.00481648
Brugia malayi aspartic protease BmAsp-1, identical 0.00591411 0.0331282 0.0307448
Entamoeba histolytica PH domain containing protein kinase, putative 0.00899664 0.0747932 0.0602935
Echinococcus granulosus hypothetical protein 0.0105316 0.0955399 0.124314
Echinococcus granulosus rhodopsin orphan GPCR 0.0105316 0.0955399 0.124314
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00463371 0.0158218 0.0205869
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00545805 0.0269639 0.0350848
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00463371 0.0158218 0.017443
Loa Loa (eye worm) hypothetical protein 0.00401951 0.00751994 0.00751994
Loa Loa (eye worm) hypothetical protein 0.00364509 0.00245906 0.00245906
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00401951 0.00751994 0.00751994
Schistosoma mansoni amine GPCR 0.0454336 0.567293 0.596039
Echinococcus multilocularis serotonin receptor 0.0150625 0.156782 0.201446
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00463371 0.0158218 0.0205869
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00391807 0.00614885 0.00481648
Echinococcus granulosus serotonin transporter 0.0236786 0.273241 0.355535
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Schistosoma mansoni voltage-gated potassium channel 0.0171087 0.184439 0.192034
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0106529 0.0971799 0.126448
Schistosoma mansoni serine/threonine protein kinase 0.00460472 0.01543 0.0136875
Loa Loa (eye worm) G-protein coupled receptor 0.0105316 0.0955399 0.0955399
Echinococcus multilocularis synaptic glycoprotein sc2 0.00773954 0.0578016 0.0722415
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.00877747 0.0718308 0.0905546
Plasmodium vivax plasmepsin V, putative 0.00591411 0.0331282 0.090238
Brugia malayi Glutamate receptor 1 precursor 0.00389483 0.00583475 0.00338401
Echinococcus granulosus tm gpcr rhodopsin 0.0105316 0.0955399 0.124314
Echinococcus granulosus fmrfamide receptor 0.0105316 0.0955399 0.124314
Trichomonas vaginalis AGC family protein kinase 0.00460472 0.01543 0.00933854
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0155687 0.163624 0.161563
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00401951 0.00751994 0.00534049
Schistosoma mansoni histamine h1 receptor 0.0105316 0.0955399 0.0982234
Echinococcus multilocularis neuropeptide Y receptor 0.0105316 0.0955399 0.121503
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105316 0.0955399 0.121503
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0105316 0.0955399 0.0982234
Onchocerca volvulus 0.00401951 0.00751994 0.0186899
Loa Loa (eye worm) hypothetical protein 0.00364509 0.00245906 0.00245906
Loa Loa (eye worm) hypothetical protein 0.0603223 0.768535 0.768535
Loa Loa (eye worm) AGC/PKN protein kinase 0.00460472 0.01543 0.01543
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0105316 0.0955399 0.0982234
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Trichomonas vaginalis AGC family protein kinase 0.013474 0.135312 0.129962
Trichomonas vaginalis AGC family protein kinase 0.013474 0.135312 0.129962
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.00401951 0.00751994 0.00978477
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0105316 0.0955399 0.343749
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) melatonin receptor type 1A 0.0105316 0.0955399 0.0955399
Echinococcus granulosus orexin receptor type 2 0.0105316 0.0955399 0.124314
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0105316 0.0955399 0.124314
Brugia malayi putative neuropeptide receptor NPR1 0.0105316 0.0955399 0.0933103
Echinococcus granulosus neuropeptides capa receptor 0.0105316 0.0955399 0.124314
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.00401951 0.00751994 0.00978477
Schistosoma mansoni serine/threonine protein kinase 0.013838 0.140231 0.145383
Loa Loa (eye worm) norepinephrine transporter 0.0236786 0.273241 0.273241
Trichomonas vaginalis AGC family protein kinase 0.013474 0.135312 0.129962
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105316 0.0955399 0.121503
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Schistosoma mansoni neuropeptide receptor 0.0105316 0.0955399 0.0982234
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.007091 0.0490357 0.0465503
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00391807 0.00614885 0.00800074
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Onchocerca volvulus 0.0236786 0.273241 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.00401951 0.00751994 0.00660625
Echinococcus multilocularis somatostatin receptor 0.0105316 0.0955399 0.121503
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0155687 0.163624 0.163624
Brugia malayi hypothetical protein 0.00591411 0.0331282 0.0307448
Trypanosoma cruzi rac serine-threonine kinase, putative 0.00899664 0.0747932 0.0723751
Entamoeba histolytica hypothetical protein 0.00773954 0.0578016 0.0430357
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00391807 0.00614885 0.00389365
Mycobacterium ulcerans hypothetical protein 0.077447 1 1
Brugia malayi G-protein coupled receptor 0.0105316 0.0955399 0.0933103
Brugia malayi Protein kinase domain containing protein 0.00460472 0.01543 0.0130029
Plasmodium falciparum plasmepsin VIII, putative 0.00591411 0.0331282 0.090238
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.00460472 0.01543 0.0169316
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0105316 0.0955399 0.0982234
Schistosoma mansoni biogenic amine (5HT) receptor 0.0150625 0.156782 0.162849
Echinococcus granulosus dro:myosuppressin receptor 0.0105316 0.0955399 0.124314
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0250151 0.291306 0.377047
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) hypothetical protein 0.0150625 0.156782 0.156782
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00401951 0.00751994 0.00751994
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.077447 1 1
Loa Loa (eye worm) hypothetical protein 0.0118844 0.113826 0.113826
Loa Loa (eye worm) cytochrome P450 family protein 0.00520669 0.0235664 0.0235664
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.00773954 0.0578016 0.0430357
Brugia malayi Cyclic-nucleotide gated cation channel 0.00391807 0.00614885 0.00369889
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0105316 0.0955399 0.0933103
Trypanosoma cruzi Protein kinase B 0.00899664 0.0747932 0.0723751
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0105316 0.0955399 0.0955399
Echinococcus multilocularis serotonin transporter 0.0236786 0.273241 0.353466
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00591411 0.0331282 0.0323636
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00591411 0.0331282 0.0323636
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0105316 0.0955399 0.0955399
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00463371 0.0158218 0.017443
Echinococcus multilocularis nmda type glutamate receptor 0.00775055 0.0579505 0.072436
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0105316 0.0955399 0.0982234
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0105316 0.0955399 0.0982234
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Plasmodium falciparum polyprenol reductase, putative 0.00773954 0.0578016 0.177182
Echinococcus granulosus protein kinase c epsilon type 0.00460472 0.01543 0.0200771
Brugia malayi hypothetical protein 0.0105316 0.0955399 0.0933103
Echinococcus granulosus biogenic amine 5HT receptor 0.0105316 0.0955399 0.124314
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.077447 1 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00591411 0.0331282 0.0323636
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0105316 0.0955399 0.121503
Mycobacterium leprae Conserved hypothetical protein 0.00365601 0.00260672 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0105316 0.0955399 0.0982234
Schistosoma mansoni glutamate receptor kainate 0.00389483 0.00583475 0.00356219
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Echinococcus granulosus nervana 2 0.00877747 0.0718308 0.0934645
Brugia malayi ORL1-like opioid receptor 0.0105316 0.0955399 0.0933103
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.00591411 0.0331282 0.0331282
Echinococcus granulosus sodium and chloride dependent glycine 0.00401951 0.00751994 0.00978477
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.00520669 0.0235664 0.0210145
Schistosoma mansoni glutamate receptor kainate 0.00389483 0.00583475 0.00356219
Brugia malayi hypothetical protein 0.0105316 0.0955399 0.0933103
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Loa Loa (eye worm) cytochrome P450 0.00365601 0.00260672 0.00260672
Echinococcus multilocularis serine:threonine protein kinase N2 0.00460472 0.01543 0.0169316
Brugia malayi Synaptic glycoprotein SC2 0.00773954 0.0578016 0.055479
Plasmodium vivax aspartyl proteinase, putative 0.0250151 0.291306 1
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) TYRA-2 protein 0.0105316 0.0955399 0.0955399
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.00401951 0.00751994 0.00507336
Echinococcus multilocularis neuropeptides capa receptor 0.0105316 0.0955399 0.121503
Echinococcus multilocularis Protein kinase C, brain isozyme 0.00460472 0.01543 0.0169316
Plasmodium vivax aspartyl protease, putative 0.00591411 0.0331282 0.090238
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.00890479 0.0735518 0.232682
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105316 0.0955399 0.0982234
Echinococcus granulosus 7tm_1 domain containing protein 0.0105316 0.0955399 0.124314
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105316 0.0955399 0.0982234
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Schistosoma mansoni cathepsin D (A01 family) 0.0737555 0.950104 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00463371 0.0158218 0.017443
Loa Loa (eye worm) aspartic protease BmAsp-1 0.00591411 0.0331282 0.0331282
Onchocerca volvulus 0.00591411 0.0331282 0.113261
Plasmodium falciparum plasmepsin VII 0.00591411 0.0331282 0.090238
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0105316 0.0955399 0.121503
Schistosoma mansoni memapsin-2 (A01 family) 0.00591411 0.0331282 0.0323636
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0118844 0.113826 0.117519
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0105316 0.0955399 0.0982234
Brugia malayi Protein kinase domain containing protein 0.013838 0.140231 0.138111
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.00460472 0.01543 0.0200771
Leishmania major cytochrome p450-like protein 0.00365601 0.00260672 0.000305875
Loa Loa (eye worm) cytochrome P450 family protein 0.00520669 0.0235664 0.0235664
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.00773954 0.0578016 0.0578016
Brugia malayi Tachykinin-like peptides receptor 99D 0.0105316 0.0955399 0.0933103
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Onchocerca volvulus 0.00401951 0.00751994 0.0186899
Schistosoma mansoni neuropeptide F-like receptor 0.0105316 0.0955399 0.0982234
Loa Loa (eye worm) hypothetical protein 0.0236786 0.273241 0.273241
Schistosoma mansoni serine/threonine protein kinase 0.00460472 0.01543 0.0136875
Plasmodium falciparum plasmepsin II 0.0250151 0.291306 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0236786 0.273241 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0105316 0.0955399 0.0955399
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00591411 0.0331282 0.0323636
Entamoeba histolytica protein kinase, putative 0.013474 0.135312 0.121761
Schistosoma mansoni voltage-gated potassium channel 0.0171087 0.184439 0.192034
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00401951 0.00751994 0.00751994
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.01378 0.139447 0.134123
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.077447 1 1
Echinococcus granulosus sex peptide receptor 0.0105316 0.0955399 0.124314
Loa Loa (eye worm) hypothetical protein 0.00401951 0.00751994 0.00751994
Schistosoma mansoni hypothetical protein 0.0105316 0.0955399 0.0982234
Entamoeba histolytica PH domain containing protein kinase, putative 0.00899664 0.0747932 0.0602935
Schistosoma mansoni biogenic amine receptor 0.0105316 0.0955399 0.0982234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105316 0.0955399 0.121503
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0142848 0.14627 0.187725
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.00463371 0.0158218 0.017443
Schistosoma mansoni serine/threonine protein kinase 0.00460472 0.01543 0.0136875
Brugia malayi Dopamine receptor 0.0105316 0.0955399 0.0933103
Echinococcus granulosus serine threonine protein kinase nrc 0.00890479 0.0735518 0.0957038
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0106529 0.0971799 0.0999539
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105316 0.0955399 0.121503
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Schistosoma mansoni voltage-gated potassium channel 0.00545805 0.0269639 0.0258587
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.00460472 0.01543 0.01543
Echinococcus granulosus biogenic amine 5HT receptor 0.0150625 0.156782 0.204001
Onchocerca volvulus 0.00773954 0.0578016 0.20438
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Echinococcus multilocularis voltage dependent calcium channel 0.0106529 0.0971799 0.123644
Loa Loa (eye worm) neuropeptide F receptor 0.0105316 0.0955399 0.0955399
Onchocerca volvulus 0.00401951 0.00751994 0.0186899
Schistosoma mansoni serine/threonine protein kinase 0.00460472 0.01543 0.0136875
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0105316 0.0955399 0.121503
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) solute carrier family 6 member 4 0.0236786 0.273241 0.273241
Echinococcus granulosus serotonin receptor 0.0105316 0.0955399 0.124314
Schistosoma mansoni serine/threonine protein kinase 0.00460472 0.01543 0.0136875
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.00925169 0.0782406 0.0989217
Brugia malayi larval opioid receptor 0.0105316 0.0955399 0.0933103
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0133822 0.13407 0.13407
Echinococcus granulosus serine/threonine protein kinase 0.00899664 0.0747932 0.0973191
Plasmodium vivax plasmepsin IV, putative 0.0250151 0.291306 1
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.00773954 0.0578016 0.177182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105316 0.0955399 0.121503
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00591411 0.0331282 0.0323636
Echinococcus multilocularis g-protein coupled receptor 0.0105316 0.0955399 0.121503
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0105316 0.0955399 0.0982234
Echinococcus multilocularis sphingosine kinase 1 0.0603223 0.768535 1
Brugia malayi hypothetical protein 0.0105316 0.0955399 0.0933103
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0118844 0.113826 0.117519
Trypanosoma brucei rac serine-threonine kinase, putative 0.013474 0.135312 0.133052
Loa Loa (eye worm) hypothetical protein 0.0236786 0.273241 0.273241
Onchocerca volvulus 0.0118844 0.113826 0.411278
Plasmodium falciparum plasmepsin IV 0.0250151 0.291306 1
Schistosoma mansoni inositol transporter 0.0142848 0.14627 0.151756
Schistosoma mansoni serine/threonine-protein kinase 0.00899664 0.0747932 0.0763304
Schistosoma mansoni sphingosine kinase A B 0.0603223 0.768535 0.8084
Echinococcus granulosus g protein coupled receptor 0.0105316 0.0955399 0.124314
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Loa Loa (eye worm) neuropeptide F receptor 0.0105316 0.0955399 0.0955399
Brugia malayi hypothetical protein 0.0105316 0.0955399 0.0933103
Loa Loa (eye worm) glutamate receptor 1 0.00389483 0.00583475 0.00583475
Echinococcus granulosus rhodopsin orphan GPCR 0.0105316 0.0955399 0.124314
Schistosoma mansoni sphingoid long chain base kinase 0.0603223 0.768535 0.8084
Echinococcus multilocularis serine:threonine protein kinase 38 0.00460472 0.01543 0.0169316
Schistosoma mansoni serine/threonine protein kinase 0.00460472 0.01543 0.0136875
Trypanosoma cruzi cytochrome P450, putative 0.00520669 0.0235664 0.0210145
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.00773954 0.0578016 0.0519723
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Echinococcus granulosus neuropeptide Y receptor 0.0105316 0.0955399 0.124314
Brugia malayi G protein-coupled receptor 0.0105316 0.0955399 0.0933103
Echinococcus granulosus voltage dependent calcium channel 0.0106529 0.0971799 0.126448
Echinococcus granulosus alpha 1A adrenergic receptor 0.0105316 0.0955399 0.124314
Brugia malayi Hr1 repeat family protein 0.00460472 0.01543 0.0130029
Brugia malayi G protein-coupled receptor F59B2.13 0.0105316 0.0955399 0.0933103
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0105316 0.0955399 0.0982234
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.013838 0.140231 0.140231
Trypanosoma cruzi rac serine-threonine kinase, putative 0.00890479 0.0735518 0.0711305
Brugia malayi Serotonin receptor 0.0105316 0.0955399 0.0933103
Brugia malayi G-protein coupled receptor 0.0105316 0.0955399 0.0933103
Echinococcus granulosus 7TM GPCR rhodopsin 0.0105316 0.0955399 0.124314
Onchocerca volvulus 0.00591411 0.0331282 0.113261
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0105316 0.0955399 0.0982234
Onchocerca volvulus Neuropeptide F receptor homolog 0.0105316 0.0955399 0.343749
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0106529 0.0971799 0.0999539
Echinococcus granulosus hyperpolarization activated cyclic 0.00391807 0.00614885 0.00800074
Echinococcus multilocularis fmrfamide receptor 0.0105316 0.0955399 0.121503
Echinococcus multilocularis serine:threonine protein kinase N2 0.00460472 0.01543 0.0169316
Echinococcus granulosus sodium:glucose cotransporter 2 0.0142848 0.14627 0.190324
Onchocerca volvulus 0.0118844 0.113826 0.411278
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00391807 0.00614885 0.00800074
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Brugia malayi Glutamate receptor 2 precursor 0.00389483 0.00583475 0.00338401
Toxoplasma gondii aspartyl protease ASP3 0.00591411 0.0331282 0.0331282
Brugia malayi hypothetical protein 0.0105316 0.0955399 0.0933103
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Schistosoma mansoni biogenic amine receptor 0.0105316 0.0955399 0.0982234
Loa Loa (eye worm) hypothetical protein 0.00391807 0.00614885 0.00614885
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.00545805 0.0269639 0.0245653
Brugia malayi putative neuropeptide receptor 0.0105316 0.0955399 0.0933103
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.00364509 0.00245906 0.00245906
Echinococcus granulosus solute carrier family 5 0.0142848 0.14627 0.190324
Schistosoma mansoni hypothetical protein 0.00365601 0.00260672 0.00015582
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.00773954 0.0578016 0.0519723
Brugia malayi Dopamine receptor protein 2 0.0105316 0.0955399 0.0933103
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Loa Loa (eye worm) hypothetical protein 0.00401951 0.00751994 0.00751994
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.00391807 0.00614885 0.00481648
Echinococcus granulosus voltage gated potassium channel 0.00545805 0.0269639 0.0350848
Echinococcus granulosus neuropeptide receptor 0.0105316 0.0955399 0.124314
Entamoeba histolytica protein kinase, putative 0.013474 0.135312 0.121761
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0155687 0.163624 0.210378
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00401951 0.00751994 0.00751994
Brugia malayi Dopamine receptor protein 1 0.0105316 0.0955399 0.0933103
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Echinococcus multilocularis dro:myosuppressin receptor 0.0105316 0.0955399 0.121503
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0236786 0.273241 0.285742
Brugia malayi hypothetical protein 0.0105316 0.0955399 0.0933103
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0236786 0.273241 0.271449
Toxoplasma gondii aspartyl protease 0.00591411 0.0331282 0.0331282
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.00890479 0.0735518 0.0928011
Echinococcus granulosus synaptic glycoprotein sc2 0.00773954 0.0578016 0.0752101
Loa Loa (eye worm) hypothetical protein 0.0118844 0.113826 0.113826
Toxoplasma gondii hypothetical protein 0.00401951 0.00751994 0.00751994
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0250151 0.291306 0.304805
Brugia malayi protein kinase C II. 0.00460472 0.01543 0.0130029
Trypanosoma brucei cytochrome P450, putative 0.00520669 0.0235664 0.0210145
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105316 0.0955399 0.121503
Brugia malayi Eukaryotic aspartyl protease family protein 0.00591411 0.0331282 0.0307448
Loa Loa (eye worm) hypothetical protein 0.00401951 0.00751994 0.00751994
Echinococcus multilocularis rac serine:threonine kinase 0.00899664 0.0747932 0.0944215
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0105316 0.0955399 0.124314
Entamoeba histolytica protein kinase 2, putative 0.00890479 0.0735518 0.0590327
Trichomonas vaginalis AGC family protein kinase 0.013474 0.135312 0.129962
Schistosoma mansoni glutamate receptor kainate 0.00389483 0.00583475 0.00356219
Echinococcus granulosus somatostatin receptor 0.0105316 0.0955399 0.124314
Loa Loa (eye worm) aspartyl protease 6 0.00591411 0.0331282 0.0331282
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0105316 0.0955399 0.121503
Schistosoma mansoni hypothetical protein 0.0105316 0.0955399 0.0982234
Echinococcus granulosus g protein coupled receptor 0.0105316 0.0955399 0.124314
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Brugia malayi neuropeptide F receptor 0.0105316 0.0955399 0.0933103
Trichomonas vaginalis AGC family protein kinase 0.00460472 0.01543 0.00933854
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00401951 0.00751994 0.00978477
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0106529 0.0971799 0.123644
Plasmodium falciparum plasmepsin IX 0.00591411 0.0331282 0.090238
Schistosoma mansoni glutamate receptor NMDA 0.010943 0.1011 0.104091
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.077447 1 1
Echinococcus granulosus g-protein coupled receptor 0.0105316 0.0955399 0.124314
Plasmodium falciparum plasmepsin I 0.0250151 0.291306 1
Loa Loa (eye worm) hypothetical protein 0.00460472 0.01543 0.01543
Loa Loa (eye worm) hypothetical protein 0.00401951 0.00751994 0.00751994
Brugia malayi Cytochrome P450 family protein 0.00520669 0.0235664 0.0211594
Schistosoma mansoni neuropeptide receptor 0.0105316 0.0955399 0.0982234
Echinococcus granulosus NDR protein kinase 0.00460472 0.01543 0.0200771
Schistosoma mansoni opsin-like receptor 0.0105316 0.0955399 0.0982234
Echinococcus multilocularis g protein coupled receptor 0.0105316 0.0955399 0.121503
Echinococcus granulosus G protein coupled receptor 139 0.0105316 0.0955399 0.124314
Schistosoma mansoni neuropeptide receptor 0.0105316 0.0955399 0.0982234
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.00460472 0.01543 0.0200771
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.00773954 0.0578016 0.0430357
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0105316 0.0955399 0.121503
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00401951 0.00751994 0.00751994
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.00460472 0.01543 0.01543
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.077447 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0105316 0.0955399 0.0933103
Echinococcus multilocularis nmda type glutamate receptor 0.00704812 0.0484562 0.0600424
Echinococcus granulosus glutamate NMDA receptor subunit 0.00925169 0.0782406 0.101805
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105316 0.0955399 0.0982234
Brugia malayi cytochrome P450 0.00365601 0.00260672 0.000148026
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0106529 0.0971799 0.126448
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0105316 0.0955399 0.0982234
Trichomonas vaginalis conserved hypothetical protein 0.00773954 0.0578016 0.0519723
Echinococcus granulosus protein kinase C gamma type 0.00460472 0.01543 0.0200771
Mycobacterium ulcerans hypothetical protein 0.0603223 0.768535 0.76793
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.00391807 0.00614885 0.00800074
Trichomonas vaginalis AGC family protein kinase 0.00469656 0.0166714 0.0105876
Plasmodium falciparum plasmepsin VI 0.0250151 0.291306 1
Brugia malayi hypothetical protein 0.0105316 0.0955399 0.0933103
Echinococcus granulosus serine:threonine protein kinase N2 0.00460472 0.01543 0.0200771
Echinococcus granulosus glutamate receptor NMDA 0.00630925 0.0384691 0.0500551
Echinococcus multilocularis neuropeptide FF receptor 2 0.0105316 0.0955399 0.121503
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0105316 0.0955399 0.0982234
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Mycobacterium tuberculosis Conserved protein 0.0603223 0.768535 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105316 0.0955399 0.121503
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0105316 0.0955399 0.121503
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0106529 0.0971799 0.123644
Echinococcus granulosus sodium and chloride dependent glycine 0.00401951 0.00751994 0.00978477
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00401951 0.00751994 0.00534049
Brugia malayi hypothetical protein 0.00401951 0.00751994 0.00507336
Loa Loa (eye worm) hypothetical protein 0.077447 1 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.00726128 0.0513373 0.0667988
Schistosoma mansoni serine/threonine kinase 0.00460472 0.01543 0.0136875
Echinococcus multilocularis neuropeptide Y receptor 0.0105316 0.0955399 0.121503
Echinococcus granulosus tachykinin peptides receptor 99D 0.0105316 0.0955399 0.124314
Brugia malayi RE15519p 0.0105316 0.0955399 0.0933103
Loa Loa (eye worm) hypothetical protein 0.0150625 0.156782 0.156782
Schistosoma mansoni atypical protein kinase C 0.00460472 0.01543 0.0136875
Schistosoma mansoni ATP-binding cassette transporter 0.00389937 0.00589617 0.00362701
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00591411 0.0331282 0.0323636
Schistosoma mansoni opsin-like receptor 0.0105316 0.0955399 0.0982234
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.00364509 0.00245906 0.00319966
Leishmania major cytochrome p450-like protein 0.00520669 0.0235664 0.0213139
Echinococcus multilocularis fmrfamide receptor 0.0105316 0.0955399 0.121503
Echinococcus multilocularis voltage dependent calcium channel 0.0106529 0.0971799 0.123644
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0456435 0.570129 0.74101
Echinococcus multilocularis serine threonine protein kinase 0.00460472 0.01543 0.0169316
Loa Loa (eye worm) hypothetical protein 0.00773954 0.0578016 0.0578016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0105316 0.0955399 0.124314
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.077447 1 1
Plasmodium vivax aspartyl proteinase, putative 0.00591411 0.0331282 0.090238
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Trypanosoma cruzi cytochrome P450, putative 0.00520669 0.0235664 0.0210145
Trichomonas vaginalis conserved hypothetical protein 0.00773954 0.0578016 0.0519723
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0105316 0.0955399 0.121503
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.00773954 0.0578016 0.0553391
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.00391807 0.00614885 0.00481648
Echinococcus granulosus high affinity choline transporter 1 0.00364509 0.00245906 0.00319966
Onchocerca volvulus 0.0105316 0.0955399 0.343749
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.00877747 0.0718308 0.0934645
Echinococcus multilocularis neuropeptide receptor A26 0.0105316 0.0955399 0.121503
Schistosoma mansoni hypothetical protein 0.0105316 0.0955399 0.0982234
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00545805 0.0269639 0.0319875
Schistosoma mansoni voltage-gated potassium channel 0.00391807 0.00614885 0.00389365
Loa Loa (eye worm) hypothetical protein 0.00591411 0.0331282 0.0331282
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0105316 0.0955399 0.124314
Loa Loa (eye worm) hypothetical protein 0.0105316 0.0955399 0.0955399
Echinococcus multilocularis orexin receptor type 2 0.0105316 0.0955399 0.121503
Schistosoma mansoni sodium-dependent amino acid transporter 0.00401951 0.00751994 0.00534049
Brugia malayi hypothetical protein 0.0105316 0.0955399 0.0933103
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00391807 0.00614885 0.00389365

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 16.7 nM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine ChEMBL. 18278859
IC50 (functional) = 16.7 nM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine ChEMBL. 18278859
IC50 (functional) = 24.8 nM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 assessed as incorporation of [3H]hypoxanthine ChEMBL. 18278859
IC50 (functional) = 24.8 nM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 assessed as incorporation of [3H]hypoxanthine ChEMBL. 18278859
IC50 (functional) = 86.1 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine ChEMBL. 18278859
IC50 (functional) = 86.1 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine ChEMBL. 18278859
IC50 (functional) = 99.4 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine ChEMBL. 18278859
IC50 (functional) = 99.4 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine ChEMBL. 18278859

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18278859

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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