Detailed information for compound 57199

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 588.821 | Formula: C31H44N2O5S2
  • H donors: 2 H acceptors: 5 LogP: 7.5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H]1CC[C@@]2([C@@H](C1)CCC1[C@H]2CC[C@@]2([C@@H]1CC[C@H]2[C@@H](CCC(=O)Oc1ccc2c(c1)sc(n2)S(=O)(=O)N)C)C)C
  • InChi: 1S/C31H44N2O5S2/c1-18(4-11-28(35)38-21-6-10-26-27(17-21)39-29(33-26)40(32,36)37)23-8-9-24-22-7-5-19-16-20(34)12-14-30(19,2)25(22)13-15-31(23,24)3/h6,10,17-20,22-25,34H,4-5,7-9,11-16H2,1-3H3,(H2,32,36,37)/t18-,19-,20-,22?,23-,24+,25+,30+,31-/m1/s1
  • InChiKey: MNGFBHCFZCPARZ-UAWSVNHRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0046 0.0351 0.1335
Echinococcus multilocularis neuropeptide FF receptor 2 0.0051 0.0416 0.0402
Echinococcus granulosus multidrug resistance associated protein 4 0.0058 0.0501 0.0493
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Plasmodium vivax unspecified product 0.0024 0.0058 0.0454
Echinococcus granulosus cathepsin l1 0.0031 0.0151 0.0138
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0086 0.1406
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0229 0.1837
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.3431 0.3421
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0416 0.0407
Echinococcus multilocularis receptor type guanylyl cyclase 0.0048 0.0373 0.0358
Echinococcus multilocularis mitogen activated protein kinase 11 0.0086 0.0865 0.0851
Brugia malayi ADAM-TS Spacer 1 family protein 0.0046 0.0347 0.0674
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0416 0.0402
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.1056 0.2114
Mycobacterium tuberculosis Conserved protein 0.0039 0.0258 0.0856
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0416 0.0407
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0058 0.0044
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.1056 0.2114
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.0754
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0688 0.0674
Schistosoma mansoni neuropeptide receptor 0.0051 0.0416 0.0407
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0416 0.0407
Schistosoma mansoni hypothetical protein 0.0101 0.1056 0.1056
Brugia malayi Dopamine receptor protein 1 0.0051 0.0416 0.0814
Entamoeba histolytica ATP-binding cassette protein, putative 0.0076 0.073 1
Trypanosoma cruzi hypothetical protein 0.0058 0.0501 0.1929
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0058 0.0505
Loa Loa (eye worm) hypothetical protein 0.0076 0.073 0.1478
Onchocerca volvulus Neuropeptide F receptor homolog 0.0051 0.0416 0.4329
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0416 0.0402
Entamoeba histolytica cysteine protease, putative 0.0046 0.0351 0.4702
Schistosoma mansoni glutamate receptor kainate 0.0399 0.4939 0.4997
Echinococcus granulosus sex peptide receptor 0.0051 0.0416 0.0407
Schistosoma mansoni multidrug resistance protein 0.0076 0.073 0.0726
Brugia malayi Cathepsin L-like precursor 0.0031 0.0151 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Echinococcus multilocularis neuropeptide receptor A26 0.0051 0.0416 0.0402
Onchocerca volvulus 0.0046 0.0351 0.3624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0051 0.0416 0.0407
Echinococcus multilocularis small conductance calcium activated potassium 0.0152 0.1723 0.1711
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0416 0.0402
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0447 0.5565 0.5632
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0416 0.0407
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0351 0.1335
Loa Loa (eye worm) TYRA-2 protein 0.0051 0.0416 0.0842
Leishmania major DNA polymerase eta, putative 0.0037 0.0229 0.0849
Echinococcus multilocularis geminin 0.0346 0.4252 0.4243
Loa Loa (eye worm) hypothetical protein 0.0086 0.0865 0.1752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0416 0.0407
Leishmania major cathepsin L-like protease 0.0046 0.0351 0.1335
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0416 0.0407
Brugia malayi angiogenesis inhibito 0.0046 0.0347 0.0674
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0243 0.2673
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus multilocularis serotonin receptor 0.0051 0.0416 0.0402
Echinococcus multilocularis nmda type glutamate receptor 0.0229 0.272 0.2709
Schistosoma mansoni opsin-like receptor 0.0051 0.0416 0.0407
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0243 0.0906
Schistosoma mansoni neuropeptide f receptor 76f 0.0051 0.0416 0.0407
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0258 0.4232
Plasmodium vivax vivapain-1 0.0024 0.0058 0.0454
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0164 0.188 0.1868
Onchocerca volvulus 0.0048 0.0373 0.3857
Schistosoma mansoni growth hormone secretagogue receptor 0.0051 0.0416 0.0407
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus granulosus 7tm_1 domain containing protein 0.0051 0.0416 0.0407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0351 0.3938
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0086 0.099
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0051 0.0416 0.0402
Brugia malayi ADAMTS-like protease 0.0046 0.0347 0.0674
Echinococcus granulosus neuropeptide receptor A26 0.0051 0.0416 0.0407
Schistosoma mansoni multidrug resistance protein 0.0076 0.073 0.0726
Entamoeba histolytica hypothetical protein 0.0076 0.073 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0416 0.0407
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0571 0.2208
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0243 0.0232
Echinococcus granulosus multidrug resistance associated protein 1 0.0076 0.073 0.0726
Schistosoma mansoni tyrosine kinase 0.0048 0.0373 0.0363
Brugia malayi putative neuropeptide receptor NPR1 0.0051 0.0416 0.0814
Brugia malayi Cathepsin L-like precursor 0.0031 0.0151 0.0277
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0447 0.5565 0.5632
Brugia malayi Cathepsin L-like precursor 0.0046 0.0351 0.0683
Schistosoma mansoni rab6-interacting 0.0021 0.0018 0.0003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0243 0.2673
Schistosoma mansoni hypothetical protein 0.0042 0.0287 0.0276
Onchocerca volvulus 0.0051 0.0416 0.4329
Echinococcus granulosus allatostatin A receptor 0.0051 0.0416 0.0407
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0018 0.0142
Loa Loa (eye worm) hypothetical protein 0.0082 0.0814 0.1648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Onchocerca volvulus 0.0026 0.0086 0.0735
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0946 0.0944
Echinococcus multilocularis glutamate receptor 2 0.0447 0.5565 0.5558
Echinococcus granulosus dna polymerase eta 0.0063 0.0571 0.0564
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0416 0.0402
Echinococcus multilocularis cysteine protease 0.0046 0.0351 0.0337
Loa Loa (eye worm) hypothetical protein 0.0101 0.1056 0.2138
Onchocerca volvulus 0.0051 0.0416 0.4329
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0086 0.1406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0058 0.0044
Trypanosoma brucei unspecified product 0.0026 0.0089 0.0294
Schistosoma mansoni zinc finger protein 0.0039 0.026 0.0248
Echinococcus multilocularis glutamate receptor NMDA 0.0181 0.2094 0.2082
Brugia malayi hypothetical protein 0.0051 0.0416 0.0814
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0086 0.0865 0.3374
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0258 0.4232
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0416 0.0407
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0416 0.0407
Schistosoma mansoni voltage-gated potassium channel 0.0092 0.0946 0.0944
Schistosoma mansoni carbonic anhydrase 0.0101 0.1056 0.1056
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0258 0.0247
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0066 0.061 0.5
Trichomonas vaginalis esterase, putative 0.0039 0.0258 0.2847
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus granulosus snurportin 1 0.0299 0.3639 0.3678
Echinococcus granulosus glutamate receptor 2 0.0447 0.5565 0.5632
Echinococcus multilocularis somatostatin receptor 0.0051 0.0416 0.0402
Onchocerca volvulus Cathepsin L homolog 0.0046 0.0351 0.3624
Brugia malayi hypothetical protein 0.0025 0.0071 0.0113
Echinococcus granulosus RUN 0.0021 0.0018 0.0003
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0048 0.0373 0.0754
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.1056 0.2114
Echinococcus multilocularis RUN 0.0021 0.0018 0.0003
Loa Loa (eye worm) hypothetical protein 0.008 0.0787 0.1593
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0118 0.1279 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0066 0.061 1
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0258 0.0965
Echinococcus multilocularis dna polymerase eta 0.0063 0.0571 0.0557
Leishmania major cathepsin L-like protease 0.0046 0.0351 0.1335
Schistosoma mansoni histamine h1 receptor 0.0051 0.0416 0.0407
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0283 0.3431 0.6946
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0076 0.073 0.2839
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0416 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.0058 0.0171
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0174
Brugia malayi hypothetical protein 0.0105 0.1115 0.2234
Echinococcus granulosus glutamate receptor NMDA 0.0181 0.2094 0.211
Plasmodium falciparum cysteine proteinase falcipain 3 0.0046 0.0351 0.2746
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0283 0.3431 0.6937
Brugia malayi Disintegrin family protein 0.011 0.118 0.2366
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0258 0.0856
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0164 0.188 0.1893
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0037
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0416 0.0402
Toxoplasma gondii cathepsin CPL 0.0046 0.0351 0.289
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0111 0.0382
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0089 0.0294
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.1056 0.1056
Brugia malayi hypothetical protein 0.0051 0.0416 0.0814
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0051 0.0416 0.0402
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0066 0.061 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0051 0.0416 0.0402
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0416 0.0402
Echinococcus granulosus cathepsin l1 0.0046 0.0351 0.0341
Echinococcus granulosus cathepsin L cysteine proteinase 0.0046 0.0351 0.0341
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0306
Echinococcus multilocularis NMDA receptor 0.0164 0.188 0.1868
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.0754
Onchocerca volvulus 0.0051 0.0416 0.4329
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0416 0.0407
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0071 0.0479
Schistosoma mansoni hypothetical protein 0.0346 0.4252 0.4299
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0051 0.0416 0.0407
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0416 0.0407
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0086 0.1406
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0086 0.0144
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0066 0.061 0.2023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0351 0.1335
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0086 0.0865 0.3374
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0258 0.0856
Brugia malayi beta-lactamase 0.0039 0.0258 0.0494
Loa Loa (eye worm) glutamate receptor 1 0.0399 0.4939 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0086 0.099
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0258 0.0965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0373 0.0754
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1029 0.206
Toxoplasma gondii ABC1 family protein 0.0039 0.0258 0.2089
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0051 0.0416 0.0407
Brugia malayi AKH receptor 0.0051 0.0416 0.0814
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0258 0.0247
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0086 0.0865 0.1751
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.0058 0.0171
Echinococcus granulosus serotonin receptor 0.0051 0.0416 0.0407
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0416 0.0407
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0416 0.0407
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0086 0.0869 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0243 0.3192
Echinococcus granulosus glutamate NMDA receptor subunit 0.0778 0.9869 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0066 0.061 1
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0018 0.0142
Plasmodium vivax vivapain-2 0.0046 0.0351 0.2746
Onchocerca volvulus 0.0051 0.0416 0.4329
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0778 0.9869 0.9869
Echinococcus granulosus dro:myosuppressin receptor 0.0051 0.0416 0.0407
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0373 0.0754
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0351 0.1335
Echinococcus granulosus adam 17 protease 0.0044 0.0324 0.0313
Echinococcus granulosus fmrfamide receptor 0.0051 0.0416 0.0407
Loa Loa (eye worm) hypothetical protein 0.0024 0.0065 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0258 0.0965
Echinococcus multilocularis zinc finger protein 0.0039 0.026 0.0245
Brugia malayi hypothetical protein 0.0051 0.0416 0.0814
Entamoeba histolytica ABC transporter, putative 0.0076 0.073 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0042 0.032
Entamoeba histolytica cysteine proteinase 1, putative 0.0024 0.0058 0.0603
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0051 0.0416 0.0402
Brugia malayi G protein-coupled receptor 0.0051 0.0416 0.0814
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0416 0.0402
Echinococcus granulosus cathepsin l cysteine peptidase 0.0046 0.0351 0.0341
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0351 0.0683
Schistosoma mansoni amine GPCR 0.0051 0.0416 0.0407
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0164 0.188 0.1893
Plasmodium vivax vivapain-2 0.0046 0.0351 0.2746
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0258 0.0856
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0086 0.1406
Trypanosoma brucei unspecified product 0.0038 0.0243 0.0906
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0051 0.0416 0.0407
Brugia malayi hypothetical protein 0.0051 0.0416 0.0814
Echinococcus granulosus metabotropic glutamate receptor 5 0.0048 0.0373 0.0363
Brugia malayi P38 map kinase family protein 2 0.0086 0.0865 0.1726
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0416 0.0407
Schistosoma mansoni glutamate receptor AMPA 0.0399 0.4939 0.4997
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0416 0.0402
Plasmodium vivax importin-beta 2, putative 0.0028 0.0111 0.087
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0086 0.1406
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0623 0.1236
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1029 0.206
Echinococcus multilocularis neuropeptide s receptor 0.0051 0.0416 0.0402
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0416 0.0402
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.1371 0.1358
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0447 0.5565 0.5632
Schistosoma mansoni rab6-interacting 0.0021 0.0018 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0416 0.0402
Echinococcus multilocularis carbonic anhydrase 0.0101 0.1056 0.1042
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.3431 0.3466
Echinococcus multilocularis cathepsin L cysteine protease 0.0046 0.0351 0.0337
Giardia lamblia DINP protein human, muc B family 0.0038 0.0243 0.3192
Onchocerca volvulus 0.0046 0.0351 0.3624
Loa Loa (eye worm) hypothetical protein 0.0086 0.0865 0.1752
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0243 0.0229
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0243 0.0232
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0416 0.0402
Loa Loa (eye worm) hypothetical protein 0.0093 0.0954 0.1931
Schistosoma mansoni DNA polymerase eta 0.0063 0.0571 0.0564
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0416 0.0407
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0051 0.0416 0.0842
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0071 0.0553
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0051 0.0416 0.0814
Entamoeba histolytica ATP-binding cassette protein, putative 0.0076 0.073 1
Brugia malayi Receptor family ligand binding region containing protein 0.0048 0.0373 0.0726
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.0065 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0416 0.0407
Brugia malayi hypothetical protein 0.0051 0.0416 0.0814
Brugia malayi ORL1-like opioid receptor 0.0051 0.0416 0.0814
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0193 0.0181
Schistosoma mansoni hypothetical protein 0.0051 0.0416 0.0407
Leishmania major p-glycoprotein e 0.0076 0.073 0.2839
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0416 0.0402
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Schistosoma mansoni multidrug resistance protein 0.0076 0.073 0.0726
Echinococcus granulosus mitogen activated protein kinase 14 0.0086 0.0865 0.0862
Brugia malayi Guanylyl cyclase protein 23 0.0048 0.0373 0.0726
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.008 0.0787 0.0783
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0258 0.2847
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0243 0.0906
Trypanosoma cruzi ISWI complex protein 0.0031 0.0147 0.0526
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0076 0.073 0.2839
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0051 0.0416 0.0814
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0416 0.0407
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0416 0.0407
Brugia malayi G protein-coupled receptor F59B2.13 0.0051 0.0416 0.0814
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0193 0.0181
Echinococcus granulosus g-protein coupled receptor 0.0051 0.0416 0.0407
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0258 0.0856
Onchocerca volvulus 0.0051 0.0416 0.4329
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0051 0.0416 0.0842
Echinococcus granulosus neuropeptide s receptor 0.0051 0.0416 0.0407
Brugia malayi Serotonin receptor 0.0051 0.0416 0.0814
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.3014 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0051 0.0416 0.0407
Echinococcus multilocularis GPCR, family 2 0.0031 0.0152 0.0138
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0258 0.0856
Echinococcus granulosus g protein coupled receptor 0.0051 0.0416 0.0407
Brugia malayi hypothetical protein 0.0051 0.0416 0.0814
Brugia malayi beta-lactamase family protein 0.0039 0.0258 0.0494
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0024 0.0065 0.0101
Echinococcus granulosus cysteine protease 0.0024 0.0058 0.0044
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0046 0.0351 0.0337
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0058 0.0603
Loa Loa (eye worm) hypothetical protein 0.0101 0.1056 0.2138
Loa Loa (eye worm) hypothetical protein 0.0028 0.0111 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Brugia malayi Importin beta-1 subunit 0.0028 0.0111 0.0195
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0351 0.1335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0416 0.0402
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0086 0.0284
Brugia malayi Reprolysin 0.0084 0.0836 0.1667
Brugia malayi Cathepsin L-like precursor 0.0046 0.0351 0.0683
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0416 0.0842
Leishmania major importin beta-1 subunit, putative 0.0023 0.0042 0.0108
Leishmania major cathepsin L-like protease 0.0046 0.0351 0.1335
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0416 0.0407
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.0058 0.0171
Brugia malayi hypothetical protein 0.0021 0.0018 0.0007
Schistosoma mansoni protein kinase 0.0048 0.0373 0.0363
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0051 0.0416 0.0814
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Brugia malayi Cathepsin L-like precursor 0.0046 0.0351 0.0683
Brugia malayi hypothetical protein 0.0021 0.0018 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0243 0.3989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0048 0.0373 0.0358
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0048 0.0373 0.0754
Schistosoma mansoni hypothetical protein 0.0031 0.0147 0.0134
Brugia malayi hypothetical protein 0.0051 0.0416 0.0814
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.3639 0.7368
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0046 0.0351 0.3938
Loa Loa (eye worm) hypothetical protein 0.0039 0.0258 0.0522
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.021 0.0424
Loa Loa (eye worm) multidrug resistance-associated protein 0.0059 0.051 0.1032
Entamoeba histolytica multidrug resistance protein, putative 0.0076 0.073 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0258 0.2847
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0243 0.0229
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Mycobacterium tuberculosis Conserved protein 0.0039 0.0258 0.0856
Trypanosoma cruzi cysteine protease, putative 0.0024 0.0058 0.0171
Echinococcus granulosus voltage gated potassium channel 0.0024 0.0065 0.0051
Brugia malayi Cathepsin L-like precursor 0.0046 0.0351 0.0683
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Schistosoma mansoni cathepsin F (C01 family) 0.0046 0.0351 0.0341
Echinococcus granulosus somatostatin receptor 0.0051 0.0416 0.0407
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0306
Echinococcus granulosus metabotropic glutamate receptor 2 0.0048 0.0373 0.0363
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0416 0.0407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0351 0.3938
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.008 0.0787 0.0773
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.0351 0.4702
Plasmodium falciparum importin beta, putative 0.0028 0.0111 0.087
Trypanosoma cruzi multidrug resistance protein E, putative 0.0076 0.073 0.2839
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0351 0.3938
Loa Loa (eye worm) cysteine protease 0.0046 0.0351 0.0711
Brugia malayi multidrug resistance related protein 1 0.0076 0.073 0.1452
Onchocerca volvulus Cathepsin L homolog 0.0046 0.0351 0.3624
Leishmania major hypothetical protein, conserved 0.0039 0.0258 0.0965
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0351 0.1335
Brugia malayi Glutamate receptor 1 precursor 0.0399 0.4939 1
Onchocerca volvulus 0.0051 0.0416 0.4329
Onchocerca volvulus 0.0051 0.0416 0.4329
Schistosoma mansoni amine GPCR 0.0051 0.0416 0.0407
Echinococcus multilocularis cathepsin L 0.0024 0.0058 0.0043
Schistosoma mansoni myosin xvIII 0.0051 0.0416 0.0407
Brugia malayi larval opioid receptor 0.0051 0.0416 0.0814
Brugia malayi hypothetical protein 0.0051 0.0416 0.0814
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0152 0.0309
Echinococcus granulosus hypothetical protein 0.0051 0.0416 0.0407
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0051 0.0416 0.0407
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0152 0.0279
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0046 0.0351 0.2746
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.011 0.1178 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0351 0.0711
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0416 0.0407
Schistosoma mansoni cathepsin F (C01 family) 0.0046 0.0351 0.0341
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0416 0.0407
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0152 0.0138
Brugia malayi hypothetical protein 0.0051 0.0416 0.0814
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0351 0.0711
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0416 0.0402
Echinococcus granulosus g protein coupled receptor 0.0051 0.0416 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0351 0.1335
Onchocerca volvulus 0.0046 0.0351 0.3624
Onchocerca volvulus 0.0051 0.0416 0.4329
Loa Loa (eye worm) ctsf protein 0.0046 0.0351 0.0711
Brugia malayi hypothetical protein 0.0051 0.0416 0.0814
Mycobacterium ulcerans hypothetical protein 0.0039 0.0258 0.4232
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0058 0.0044
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0051 0.0416 0.0407
Brugia malayi G-protein coupled receptor 0.0051 0.0416 0.0814
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0046 0.0351 0.0711
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0243 0.0807
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0351 0.3938
Brugia malayi RNA, U transporter 1 0.008 0.0783 0.1561
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0152 0.0279
Echinococcus multilocularis orexin receptor type 2 0.0051 0.0416 0.0402
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0258 0.0856
Echinococcus granulosus carbonic anhydrase 0.0101 0.1056 0.1056
Loa Loa (eye worm) hypothetical protein 0.0039 0.0258 0.0522
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0051 0.0416 0.0407
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.0754
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0018 0.0003
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Onchocerca volvulus 0.0051 0.0416 0.4329
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0084 0.0845 0.171
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0258 0.2847
Echinococcus granulosus carbonic anhydrase 0.0101 0.1056 0.1056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.3431 0.3466
Loa Loa (eye worm) glutamate receptor 0.0048 0.0373 0.0754
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0051 0.0416 0.0407
Schistosoma mansoni metabotropic glutamate receptor 0.0048 0.0373 0.0363
Echinococcus multilocularis sex peptide receptor 0.0051 0.0416 0.0402
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0416 0.0407
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.012 0.1311 0.1315
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.0151 0.0138
Schistosoma mansoni neuropeptide receptor 0.0051 0.0416 0.0407
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0076 0.073 0.2839
Leishmania major hypothetical protein, conserved 0.0031 0.0147 0.0526
Leishmania major cathepsin L-like protease 0.0046 0.0351 0.1335
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0416 0.0407
Echinococcus multilocularis disintegrin and metalloproteinase 0.011 0.118 0.1167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.3431 0.3421
Echinococcus multilocularis glutamate receptor 2 0.0399 0.4939 0.4931
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0258 0.0247
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0174
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0086 0.0281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0416 0.0407
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0101 0.1056 0.2138
Schistosoma mansoni glutamate receptor NMDA 0.0778 0.9869 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0071 0.0553
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0086 0.099
Brugia malayi Tachykinin-like peptides receptor 99D 0.0051 0.0416 0.0814
Schistosoma mansoni hypothetical protein 0.0031 0.0152 0.014
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0086 0.0281
Leishmania major hypothetical protein, conserved 0.0025 0.0071 0.0221
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0243 0.0807
Trypanosoma brucei multidrug resistance protein E 0.0076 0.073 0.2839
Echinococcus multilocularis mitogen activated protein kinase 14 0.0086 0.0865 0.0851
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Loa Loa (eye worm) hypothetical protein 0.0063 0.0571 0.1156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0351 0.1335
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0065 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0089 0.0294
Loa Loa (eye worm) hypothetical protein 0.0039 0.0258 0.0522
Schistosoma mansoni zinc finger protein 0.0031 0.0147 0.0134
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0416 0.0402
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.0351 0.4702
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0051 0.0416 0.0402
Schistosoma mansoni opsin-like receptor 0.0051 0.0416 0.0407
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.023 0.2743 0.2732
Plasmodium falciparum MO15-related protein kinase 0.0118 0.1279 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.2533 0.2556
Giardia lamblia ABC transporter, putative 0.0076 0.073 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0416 0.0402
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0128 0.1413 0.1418
Echinococcus multilocularis adam 0.0105 0.1115 0.1102
Brugia malayi PHD-finger family protein 0.005 0.0399 0.0781
Loa Loa (eye worm) hypothetical protein 0.0073 0.07 0.1417
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus multilocularis snurportin 1 0.0299 0.3639 0.3629
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus multilocularis tyrosine kinase 0.0048 0.0373 0.0358
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0447 0.5565 0.5558
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Loa Loa (eye worm) hypothetical protein 0.0099 0.1029 0.2084
Leishmania major carbonic anhydrase-like protein 0.0214 0.2533 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0051 0.0416 0.0407
Echinococcus granulosus nmda type glutamate receptor 0.0411 0.5091 0.5151
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.0754
Trypanosoma brucei ISWI complex protein 0.0031 0.0147 0.0526
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0688 0.0683
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0042 0.032
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0065 0.0051
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0015 0.0117
Echinococcus granulosus cathepsin L cysteine protease 0.0024 0.0058 0.0044
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0084 0.0845 0.1685
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0048 0.0373 0.3857
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0152 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.0058 0.0171
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0243 0.0906
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0048 0.0373 0.0358
Onchocerca volvulus 0.0092 0.0937 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0416 0.0407
Onchocerca volvulus 0.0039 0.0258 0.261
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Schistosoma mansoni amine GPCR 0.0051 0.0416 0.0407
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0071 0.0221
Loa Loa (eye worm) hypothetical protein 0.0152 0.1723 0.3488
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0151 0.1907
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0351 0.3938
Echinococcus granulosus neuropeptide receptor 0.0051 0.0416 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0351 0.1335
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0571 0.1129
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0164 0.188 0.1868
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0051 0.0416 0.0407
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0258 0.0856
Schistosoma mansoni hypothetical protein 0.0031 0.0152 0.014
Echinococcus granulosus alpha 1A adrenergic receptor 0.0051 0.0416 0.0407
Schistosoma mansoni lipoxygenase 0.0125 0.1371 0.1376
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0447 0.5565 0.5558
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0337 0.0323
Loa Loa (eye worm) hypothetical protein 0.0068 0.0636 0.1287
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0128 0.1413 0.14
Echinococcus granulosus nmda type glutamate receptor 0.0229 0.272 0.2745
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0151 0.1597
Onchocerca volvulus 0.0048 0.0373 0.3857
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0086 0.0284
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.2533 1
Leishmania major cathepsin L-like protease 0.0046 0.0351 0.1335
Echinococcus granulosus neuropeptide FF receptor 2 0.0051 0.0416 0.0407
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0051 0.0416 0.0402
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0416 0.0402
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.1056 0.1056
Schistosoma mansoni hypothetical protein 0.0051 0.0416 0.0407
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0039 0.0258 0.0522
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0051 0.0416 0.0407
Schistosoma mansoni dihydroceramide desaturase 0.011 0.118 0.1182
Schistosoma mansoni hypothetical protein 0.0067 0.0623 0.0618
Leishmania major cysteine peptidase A (CPA) 0.0046 0.0351 0.1335
Echinococcus multilocularis cysteine protease 0.0046 0.0351 0.0337
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0152 0.014
Echinococcus granulosus glutamate receptor subunit protein glur 0.0164 0.188 0.1893
Schistosoma mansoni calcium-activated potassium channel 0.0145 0.1627 0.1635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0351 0.1335
Loa Loa (eye worm) hypothetical protein 0.0046 0.0347 0.0702
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0337 0.0327
Loa Loa (eye worm) hypothetical protein 0.0077 0.0752 0.1523
Echinococcus granulosus dna polymerase kappa 0.0038 0.0243 0.0232
Mycobacterium leprae Probable lipase LipE 0.0039 0.0258 1
Onchocerca volvulus 0.0051 0.0416 0.4329
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0086 0.0869 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Giardia lamblia Multidrug resistance-associated protein 1 0.0076 0.073 1
Schistosoma mansoni hypothetical protein 0.0031 0.0152 0.014
Leishmania major DNA polymerase eta, putative 0.0063 0.0571 0.2208
Giardia lamblia Multidrug resistance-associated protein 1 0.0075 0.0721 0.9872
Schistosoma mansoni ATP-binding cassette transporter 0.04 0.4948 0.5006
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0058 0.0603
Echinococcus multilocularis carbonic anhydrase II 0.0214 0.2533 0.2522
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0351 0.1335
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0416 0.0407
Echinococcus granulosus atrial natriuretic peptide receptor 0.0048 0.0373 0.0363
Schistosoma mansoni opsin-like receptor 0.0051 0.0416 0.0407
Entamoeba histolytica hypothetical protein 0.0048 0.0373 0.5001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0447 0.5565 0.5558
Leishmania major extracellular receptor, putative 0.0048 0.0373 0.142
Echinococcus granulosus disintegrin and metalloproteinase 0.011 0.118 0.1182
Schistosoma mansoni lipoxygenase 0.0087 0.0882 0.088
Onchocerca volvulus 0.0051 0.0416 0.4329
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0051 0.0416 0.0402
Loa Loa (eye worm) hypothetical protein 0.0086 0.0865 0.1752
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0031 0.0151 0.0541
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.2533 1
Brugia malayi hypothetical protein 0.0048 0.0373 0.0726
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Onchocerca volvulus 0.0046 0.0351 0.3624
Loa Loa (eye worm) hypothetical protein 0.0076 0.073 0.1478
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.0754
Onchocerca volvulus Cathepsin F homolog 0.0046 0.0351 0.3624
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0229 0.0849
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.0571 0.2208
Schistosoma mansoni glutamate receptor kainate 0.0399 0.4939 0.4997
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.0754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Echinococcus granulosus peptide allatostatin:somatostatin 0.0051 0.0416 0.0407
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Echinococcus multilocularis glutamate receptor 2 0.0283 0.3431 0.3422
Echinococcus granulosus carbonic anhydrase 0.0101 0.1056 0.1056
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0076 0.073 0.2839
Onchocerca volvulus 0.0051 0.0416 0.4329
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0048 0.0373 0.0726
Schistosoma mansoni multidrug resistance protein 0.0076 0.073 0.0726
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0048 0.0373 0.0358
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.0065 0.0051
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0086 0.0281
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0042 0.032
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0258 0.2847
Trypanosoma brucei carbonic anhydrase-like protein 0.0214 0.2533 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0351 0.1335
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.0754
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0164 0.188 0.1868
Schistosoma mansoni biogenic amine receptor 0.0051 0.0416 0.0407
Schistosoma mansoni polycystin 1-related 0.0021 0.0018 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0174
Schistosoma mansoni neuropeptide receptor 0.0051 0.0416 0.0407
Leishmania major DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Giardia lamblia MRP-like ABC transporter 0.0076 0.073 1
Schistosoma mansoni biogenic amine receptor 0.0051 0.0416 0.0407
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0416 0.0407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0351 0.3938
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0051 0.0416 0.0814
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.2533 0.2556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0351 0.3938
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0351 0.1335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.3431 0.3466
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.012 0.1311 0.1298
Loa Loa (eye worm) hypothetical protein 0.0034 0.0193 0.0392
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0076 0.073 0.2839
Mycobacterium ulcerans lipase LipD 0.0039 0.0258 0.4232
Schistosoma mansoni calcium-activated potassium channel 0.0152 0.1723 0.1733
Echinococcus granulosus neuropeptide receptor 0.0051 0.0416 0.0407
Loa Loa (eye worm) hypothetical protein 0.0072 0.0686 0.1389
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0243 0.0492
Echinococcus granulosus zinc finger protein 0.0039 0.026 0.0248
Echinococcus multilocularis multidrug resistance associated protein 4 0.0058 0.0501 0.0487
Echinococcus granulosus small conductance calcium activated potassium 0.0152 0.1723 0.1733
Echinococcus multilocularis serotonin receptor 0.0051 0.0416 0.0402
Echinococcus granulosus adam 0.0105 0.1115 0.1116
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0416 0.0402
Chlamydia trachomatis glutamine binding protein 0.0066 0.061 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus granulosus GPCR family 2 0.0031 0.0152 0.014
Echinococcus multilocularis carbonic anhydrase 0.0101 0.1056 0.1042
Onchocerca volvulus 0.0051 0.0416 0.4329
Brugia malayi Cytochrome P450 family protein 0.0026 0.0083 0.0137
Leishmania major cathepsin L-like protease 0.0046 0.0351 0.1335
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0416 0.0842
Onchocerca volvulus 0.0051 0.0416 0.4329
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Schistosoma mansoni hypothetical protein 0.0346 0.4252 0.4299
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0076 0.073 0.6147
Brugia malayi G-protein coupled receptor 0.0051 0.0416 0.0814
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0416 0.0407
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0258 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0048 0.0373 0.0726
Onchocerca volvulus 0.0051 0.0416 0.4329
Brugia malayi Doublecortin family protein 0.0021 0.0018 0.0007
Brugia malayi ABC transporter transmembrane region family protein 0.0076 0.073 0.1452
Brugia malayi Receptor family ligand binding region containing protein 0.0048 0.0373 0.0726
Echinococcus granulosus tyrosine kinase 0.0048 0.0373 0.0363
Echinococcus granulosus carbonic anhydrase II 0.0214 0.2533 0.2556
Schistosoma mansoni amine GPCR 0.0051 0.0416 0.0407
Loa Loa (eye worm) hypothetical protein 0.0143 0.16 0.3239
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0018 0.0003
Brugia malayi GnHR receptor homolog 0.0051 0.0416 0.0814
Echinococcus multilocularis multidrug resistance associated protein 7 0.0076 0.073 0.0716
Echinococcus multilocularis mitogen activated protein kinase 11 0.0086 0.0865 0.0851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0042 0.0108
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Leishmania major cathepsin L-like protease 0.0046 0.0351 0.1335
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus granulosus g protein coupled receptor 0.0051 0.0416 0.0407
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0086 0.0865 0.3374
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0193 0.0179
Brugia malayi Protein-tyrosine phosphatase 0.0098 0.1026 0.2053
Brugia malayi Bromodomain containing protein 0.0077 0.075 0.1493
Schistosoma mansoni hypothetical protein 0.0031 0.0152 0.014
Schistosoma mansoni amine GPCR 0.0051 0.0416 0.0407
Schistosoma mansoni hypothetical protein 0.0051 0.0416 0.0407
Echinococcus multilocularis G-protein coupled receptor, putative 0.0051 0.0416 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0089 0.0294
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.0754
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0416 0.0402
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0086 0.1406
Loa Loa (eye worm) fibroinase 0.0046 0.0351 0.0711
Schistosoma mansoni hypothetical protein 0.0152 0.1723 0.1733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0351 0.3938
Loa Loa (eye worm) reprolysin 0.0128 0.1413 0.286
Trypanosoma brucei unspecified product 0.0026 0.0089 0.0294
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0024 0.0058 0.0171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0051 0.0416 0.0407
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Echinococcus multilocularis cathepsin L cysteine protease 0.0046 0.0351 0.0337
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0076 0.073 0.1478
Mycobacterium tuberculosis Conserved protein 0.0039 0.0258 0.0856
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.0058 0.0171
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0416 0.0407
Mycobacterium ulcerans hypothetical protein 0.0026 0.0086 0.1406
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0083 0.0167
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0128 0.1413 0.1418
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0058 0.0603
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0018 0.0003
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0076 0.073 0.2839
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0051 0.0416 0.0842
Trypanosoma cruzi cruzipain precursor, putative 0.0046 0.0351 0.1335
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Echinococcus granulosus importin subunit beta 1 0.0028 0.0111 0.0098
Echinococcus multilocularis mitogen activated protein kinase 14 0.0086 0.0865 0.0851
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0258 0.0522
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0351 0.3938
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Brugia malayi neuropeptide F receptor 0.0051 0.0416 0.0814
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0416 0.0402
Brugia malayi Melatonin receptor type 1A 0.0051 0.0416 0.0814
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0416 0.0407
Schistosoma mansoni hypothetical protein 0.0051 0.0416 0.0407
Echinococcus granulosus cathepsin L 0.0024 0.0058 0.0044
Echinococcus granulosus orexin receptor type 2 0.0051 0.0416 0.0407
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0416 0.0402
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0258 0.0243
Loa Loa (eye worm) hypothetical protein 0.0086 0.0864 0.175
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Loa Loa (eye worm) glutamate receptor 2 0.0399 0.4939 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0214 0.2533 0.5115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0351 0.1335
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0447 0.5565 0.5632
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.1056 0.2114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0193 0.0181
Brugia malayi Bromodomain containing protein 0.0151 0.1712 0.3446
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0086 0.0144
Brugia malayi cathepsin L-like precursor 0.0031 0.0151 0.0277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0351 0.1335
Brugia malayi Dopamine receptor protein 2 0.0051 0.0416 0.0814
Schistosoma mansoni neuropeptide receptor 0.0051 0.0416 0.0407
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0416 0.0402
Echinococcus granulosus multidrug resistance associated protein 7 0.0076 0.073 0.0726
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0193 0.0179
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0258 0.2017
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0356
Echinococcus multilocularis allatostatin A receptor 0.0051 0.0416 0.0402
Giardia lamblia Multidrug resistance-associated protein 1 0.0076 0.073 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0193 0.0181
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus multilocularis carbonic anhydrase 0.0101 0.1056 0.1042
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0111 0.0096
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0071 0.0553
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0373 0.0754
Leishmania major pentamidine resistance protein 1 0.0076 0.073 0.2839
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0018 0.0003
Schistosoma mansoni metabotropic glutamate receptor 0.0048 0.0373 0.0363
Entamoeba histolytica hypothetical protein 0.0023 0.0042 0.0382
Onchocerca volvulus 0.0046 0.0351 0.3624
Loa Loa (eye worm) hypothetical protein 0.0046 0.0347 0.0702
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0051 0.0416 0.0842
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0071 0.0221
Echinococcus multilocularis multidrug resistance associated protein 1 0.0076 0.073 0.0716
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0051 0.0416 0.0402
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0111 0.0828
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.1056 0.1056
Brugia malayi neuropeptide F receptor 0.0051 0.0416 0.0814
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0076 0.073 0.2839
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Loa Loa (eye worm) hypothetical protein 0.0039 0.0258 0.0522
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0164 0.188 0.1893
Brugia malayi sulfakinin receptor protein 0.0051 0.0416 0.0814
Onchocerca volvulus 0.0039 0.0258 0.261
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0086 0.0865 0.3374
Echinococcus granulosus glutamate receptor 2 0.0283 0.3431 0.3467
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0051 0.0416 0.0402
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0105 0.1115 0.1116
Brugia malayi RE15519p 0.0051 0.0416 0.0814
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0193 0.0181
Schistosoma mansoni glutamate receptor NMDA 0.0628 0.7913 0.8015
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0287 0.0582
Onchocerca volvulus 0.0046 0.0351 0.3624
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Schistosoma mansoni tyrosine kinase 0.0048 0.0373 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0151 0.1597
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Brugia malayi Dopamine receptor 0.0051 0.0416 0.0814
Onchocerca volvulus 0.0051 0.0416 0.4329
Trypanosoma cruzi extracellular receptor, putative 0.0048 0.0373 0.142
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0193 0.0181
Echinococcus granulosus receptor type guanylyl cyclase 0.0048 0.0373 0.0363
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0416 0.0402
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0214 0.2533 0.513
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0111 0.0382
Plasmodium falciparum cysteine proteinase falcipain 1 0.0024 0.0058 0.0454
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0015 0.003
Echinococcus granulosus G protein coupled receptor 139 0.0051 0.0416 0.0407
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0051 0.0416 0.0842
Onchocerca volvulus 0.0046 0.0351 0.3624
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0086 0.1406
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.1371 0.1376
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0416 0.0407
Schistosoma mansoni hypothetical protein 0.0164 0.188 0.1893
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0243 0.0906
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Schistosoma mansoni importin beta-1 0.0028 0.0111 0.0098
Echinococcus granulosus geminin 0.0346 0.4252 0.4299
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0258 0.0494
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0048 0.0373 0.0754
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0051 0.0416 0.0814
Loa Loa (eye worm) melatonin receptor type 1A 0.0051 0.0416 0.0842
Echinococcus granulosus tachykinin peptides receptor 99D 0.0051 0.0416 0.0407
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0416 0.0842
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0416 0.0407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0351 0.3938
Brugia malayi follicle stimulating hormone receptor 0.0051 0.0416 0.0814
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0243 0.0906
Mycobacterium ulcerans beta-lactamase 0.0039 0.0258 0.4232
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0046 0.0351 0.3938
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0214 0.2533 0.5115
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0076 0.073 0.2839
Loa Loa (eye worm) disintegrin family protein 0.0066 0.0603 0.1221
Plasmodium falciparum carbonic anhydrase 0.0101 0.1056 0.8256
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0046 0.0351 0.2746
Loa Loa (eye worm) hypothetical protein 0.0025 0.0071 0.0143
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0243 0.0464
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.0065 0.005
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1029 0.2084
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0152 0.014
Entamoeba histolytica cysteine protease, putative 0.0024 0.0058 0.0603
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0058 0.0087
Trypanosoma brucei p-glycoprotein 0.0076 0.073 0.2839
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0071 0.0221
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0086 0.0144
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0084 0.0845 0.0831
Brugia malayi putative neuropeptide receptor 0.0051 0.0416 0.0814
Schistosoma mansoni hypothetical protein 0.0299 0.3639 0.3678
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0015 0.0117
Loa Loa (eye worm) hypothetical protein 0.0039 0.0258 0.0522
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0018 0.0003
Echinococcus multilocularis g-protein coupled receptor 0.0051 0.0416 0.0402
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0058 0.0087
Brugia malayi Serotonin receptor 0.0051 0.0416 0.0814
Leishmania major ABC-thiol transporter 0.0076 0.073 0.2839
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0416 0.0407
Toxoplasma gondii hypothetical protein 0.0101 0.1056 0.8948
Brugia malayi Glutamate receptor 2 precursor 0.0399 0.4939 1
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0018 0.0037
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0243 0.0232
Loa Loa (eye worm) hypothetical protein 0.0076 0.0737 0.1493
Brugia malayi metabotropic glutamate receptor type 2 0.0048 0.0373 0.0726
Trypanosoma cruzi ISWI complex protein 0.0031 0.0147 0.0526
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0084 0.0845 0.0842
Echinococcus multilocularis dro:myosuppressin receptor 0.0051 0.0416 0.0402
Onchocerca volvulus 0.0031 0.0151 0.1449
Schistosoma mansoni biogenic amine receptor 0.0051 0.0416 0.0407
Onchocerca volvulus 0.0051 0.0416 0.4329
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.3431 0.3466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0351 0.1335
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Brugia malayi Cathepsin L-like precursor 0.0046 0.0351 0.0683
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0018 0.0003
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Loa Loa (eye worm) hypothetical protein 0.0031 0.0151 0.0306
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0128 0.1413 0.1418
Schistosoma mansoni loxhd1 0.0021 0.0018 0.0003
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0416 0.0402
Brugia malayi Cathepsin L-like cysteine proteinase 0.0031 0.0151 0.0277
Schistosoma mansoni bromodomain containing protein 0.0128 0.1405 0.141
Loa Loa (eye worm) beta-lactamase 0.0039 0.0258 0.0522
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0337 0.0327
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.0754
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0058 0.0603
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Schistosoma mansoni adenoreceptor 0.0051 0.0416 0.0407
Loa Loa (eye worm) carbonic anhydrase 3 0.0214 0.2533 0.513
Entamoeba histolytica ATP-binding cassette protein, putative 0.0076 0.073 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0076 0.073 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1056 0.2138
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0416 0.0407
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.3431 0.3466
Brugia malayi beta-lactamase family protein 0.0039 0.0258 0.0494
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0416 0.0842
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Schistosoma mansoni glutamate receptor kainate 0.0399 0.4939 0.4997
Echinococcus granulosus mitogen activated protein kinase 11 0.0086 0.0865 0.0862
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0416 0.0402
Loa Loa (eye worm) hypothetical protein 0.0051 0.0416 0.0842
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0046 0.0351 0.0337
Brugia malayi Cathepsin L-like precursor 0.0046 0.0351 0.0683
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0447 0.5565 0.5558
Entamoeba histolytica cysteine proteinase 2 0.0024 0.0058 0.0603
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0243 0.3989
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0258 0.2847
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0051 0.0416 0.4329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0058 0.0505
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0416 0.0407
Onchocerca volvulus 0.0039 0.0258 0.261
Loa Loa (eye worm) hypothetical protein 0.0075 0.0721 0.1459
Schistosoma mansoni glutamate receptor AMPA 0.0399 0.4939 0.4997
Echinococcus multilocularis nmda type glutamate receptor 0.0411 0.5091 0.5083
Loa Loa (eye worm) hypothetical protein 0.0031 0.0152 0.0309
Plasmodium vivax vivapain-3 0.0024 0.0058 0.0454
Loa Loa (eye worm) hypothetical protein 0.0067 0.0623 0.1262
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.1056 0.2114

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2 nM Inhibitory activity against human recombinant carbonic anhydrase II (CA2) ChEMBL. 12039560
Ki (binding) = 9 nM Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes ChEMBL. 12039560
Ki (binding) = 40 nM Inhibitory activity against human recombinant carbonic anhydrase I (CA1) ChEMBL. 12039560

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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